IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40 values | effect stringclasses 10 values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q13370 | P31749 | 0 | phosphorylation | up-regulates | 0.687 | Pde3b is a physiological substrate of akt and that akt-mediated phosphorylation of pde3b on serine-273 is important for insulin-induced activation of pde3b. | SIGNOR-252583 |
P40763 | P29597 | 0 | phosphorylation | up-regulates | 0.687 | Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated | SIGNOR-256255 |
Q04721 | O00587 | 0 | binding | up-regulates | 0.687 | These observations indicate that the fringe proteins directly modify notch2, which is consistent with the recent finding that fringe is a glycosyltransferase that directly modifies notch (30, 31). It was further indicated that lfng does this at a site from the n terminus through the 15th egf repeat of notch2, and mfng does so at a site from the 23rd through the 29th egf repeat of notch2. | SIGNOR-107708 |
P02818 | P38435 | 0 | carboxylation | up-regulates activity | 0.687 | Thus, vitamin K acts as a cofactor for GGCX via the vitamin K cycle and exerts physiological effects through its regulation of VKDPs [29]. More than 20 VKDPs have been found. Osteocalcin promotes bone formation, and blood coagulation factors II, VII, IX, and X activate blood coagulation. Matrix Gla protein suppresses cardiovascular calcification, and brain-expressed Gas 6 promotes neural differentiation [29]. GGCX is an enzyme that converts glutamic acid (Glu) residues to Gla residues, so that the Gla-containing proteins can exert various physiological actions such as blood coagulation and bone formation. | SIGNOR-265922 |
P21802 | O60258 | 0 | binding | up-regulates | 0.687 | Fgfs bind and activate high-affinity receptor tyrosine kinases. The cloning of fgf receptors (fgfrs) has identified four distinct genes | SIGNOR-42365 |
P36896 | P27037 | 0 | phosphorylation | up-regulates | 0.687 | In this complex, the actrii??/Iib kinase phosphorylates alk4 within a glycine- and serine-rich region called the gs domain, and this phosphorylation event activates the alk4 kinase | SIGNOR-99995 |
Q6P1M3 | P41743 | 0 | phosphorylation | up-regulates activity | 0.687 | This finding indicates that both mLgl-2 and mLgl-1 are phosphorylated in vivo in an aPKC lambda activity-dependent manner. | SIGNOR-263180 |
P13807 | P49841 | 0 | phosphorylation | down-regulates activity | 0.686 | Glycogen synthase kinase-3 phosphorylates three serine residues on glycogen synthase (sites 3a, 3b and 3c) which are all located in the same nine-amino-acid segment of the polypeptide chain. The sequence in this region is: Arg-Tyr-Pro-Arg-Pro-Ala-Ser(P)-Val-Pro-Pro-Ser(P)-Pro-Ser-Leu-Ser(P)-Arg-. | SIGNOR-253007 |
O94992 | Q4G0J3 | 0 | binding | down-regulates activity | 0.686 | To investigate whether LARP7 is part of the known 7SK RNP implicated in the regulation of transcription, co‐immunoprecipitation studies were performed using the nuclear extracts of HeLa cells (Fig 3A, lanes 1–4). Antibodies against LARP7, CDK9 and HEXIM1 efficiently precipitated 7SK RNA, whereas no RNA was found in the control (Fig 3A, lower panel, lanes 1–4). Interestingly, HEXIM1, CDK9, CYCT1 and LARP7 were present in all immunopurifications, as determined by mass spectrometry of silver‐stained gels (Fig 3A; data not shown) and western blotting. In conclusion, these experiments show that LARP7 negatively regulates not only viral but also cellular POLII class genes through the 7SK P‐TEFb system. | SIGNOR-261183 |
Q92934 | P45983 | 0 | phosphorylation | down-regulates | 0.686 | Jnk phosphorylates bad at threonine 201, thereby inhibiting bad association with the antiapoptotic molecule bcl-x(l) | SIGNOR-121940 |
P35222 | Q9H6I2 | 0 | binding | down-regulates | 0.686 | Two additional sox proteins, xsox17alfa and xsox3 , likewise bind to beta-catenin and inhibit its tcf-mediated signaling activity | SIGNOR-72006 |
P08559 | Q16654 | 0 | phosphorylation | down-regulates | 0.686 | Mammalian pyruvate dehydrogenase (?2_2) (e1) is regulated by phosphorylation-dephosphorylation, catalyzed by the e1-kinase and the phospho-e1-phosphatase. | SIGNOR-33201 |
Q8WXE1 | P15927 | 0 | binding | up-regulates | 0.686 | Ssdna lesions are then coated by replication protein a (rpa), recruiting atr/atrip (atr-interacting protein) complexes via recognition and association of rpa-ssdna by atrip. | SIGNOR-163176 |
Q12933 | Q14164 | 0 | phosphorylation | up-regulates activity | 0.686 | IKKepsilon phosphorylates TRAF2 at Ser11 to activate NF-kappaB and promote malignant transformation. | SIGNOR-279195 |
Q5UIP0 | Q12888 | 0 | binding | up-regulates activity | 0.686 | RIF1 is recruited to DSBs via the N-terminal phospho-SQ/TQ domain of 53BP1, and DSBs generated by ionizing radiation or during CSR are hyperresected in the absence of RIF1. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination. | SIGNOR-259058 |
Q99661 | P06493 | 0 | phosphorylation | down-regulates | 0.686 | We show here that cyclin-dependent kinase 1 (cdk1) phosphorylates t537 in the core domain of mcak and attenuates its microtubule-destabilizing activity in vitro and in vivo. Phosphorylation of mcak by cdk1 promotes the release of mcak from centrosomes and is required for proper spindle formation. | SIGNOR-164761 |
P62993 | P35968 | 0 | relocalization | up-regulates activity | 0.686 | In a similar fashion, KDR associates with Grb2 and Nck in a ligand-dependent fashion, suggesting Shc, Grb2, and Nck as potential candidates involved in the regulation of endothelial function. | SIGNOR-261948 |
O43474 | P35222 | 0 | binding | up-regulates activity | 0.686 | The interaction of Beta-catenin with Tcf is important for Beta-catenin s's function in iPSCs induction. In addition, Beta-catenin interacts with Oct4, Sox2, and Klf4, respectively. In the reprogramming process, Beta-catenin further enhances expression of pluripotency-related genes. | SIGNOR-242100 |
Q92918 | P46108 | 0 | binding | up-regulates | 0.686 | We found that hpk1 interacted with crk and crkl adaptor proteins in vitro and in vivo and that the proline-rich motifs within hpk1 were involved in the differential interaction of hpk1 with the crk proteins and grb2. Crk and crkl not only activated hpk1 but also synergized with hpk1 in the activation of jnk. | SIGNOR-63988 |
P35221 | P12830 | 0 | binding | up-regulates | 0.686 | Additionally, the E-cadherin associated protein _-catenin regulates YAP directly by sequestering YAP/14-3-3 complexes in the cytoplasm. | SIGNOR-203468 |
Q9Y397 | Q7Z5G4 | 0 | binding | up-regulates activity | 0.686 | DHHC9 and GCP16 form a protein complex, and DHHC9 requires GCP16 for protein fatty acyltransferase activity and protein stability. | SIGNOR-261353 |
Q02223 | O75888 | 0 | binding | up-regulates | 0.686 | April is involved in stimulation of b and t cell function. April functions via binding to bcma and taci and competes with tall-i for receptor binding. | SIGNOR-81386 |
O15392 | P06493 | 0 | phosphorylation | up-regulates | 0.686 | Survivin is a member of the inhibitor of apoptosis gene family that has been implicated in both apoptosis inhibition and regulation of mitosisin synchronized cultures, cytosolic survivin abruptly increased at mitosis, physically associated with p34(cdc2), and was phosphorylated by p34(cdc2) on thr(34), in vivo | SIGNOR-115129 |
P62993 | P15498 | 0 | binding | up-regulates | 0.686 | Recently, we have shown that the proto-oncogene vav product (vav) is also tyrosine-phosphorylated by treatment with gm-csf and epo and is constitutively associated with the sh3 domain of grb2/ash in ut-7. | SIGNOR-49362 |
P43351 | P00519 | 0 | phosphorylation | up-regulates activity | 0.685 | C-Abl tyrosine kinase associates with and phosphorylates Rad52 on tyrosine 104. he functional significance of c-Abl-dependent phosphorylation of Rad52 is underscored by our findings that cells that express the phosphorylation-resistant Rad52 mutant, in which tyrosine 104 is replaced by phenylalanine, exhibit compromised nuclear foci formation in response to IR. | SIGNOR-251435 |
Q15796 | Q6ZNA4 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.685 | Arkadia represses the expression of myoblast differentiation markers through degradation of ski and the ski-bound smad complex in c2c12 myoblastsarkadia bound smad2/3 via ski to induce the ubiquitination of smad2/3. These results suggest that arkadia targets ski-bound, inactive phospho-smad2/3 to regulate positively myostatin/tgf-beta signaling. | SIGNOR-236873 |
Q13315 | Q15554 | 0 | binding | down-regulates activity | 0.685 | It is not yet clear how the presence of TRF2 at telomeres averts the activation of the ATM kinase.> In this regard, overexpression of TRF2can dampen the activation of the ATM kinase, even at nontelomeric sites of DNA damage (95). Furthermore, TRF2 can interact with the ATM kinase as well as with the Mre11 complex | SIGNOR-263323 |
P42336 | Q9Y4H2 | 0 | binding | up-regulates activity | 0.685 | These results strongly suggest that the IGF2–IGF1R–IRS2 axis signals to PI3K in CRC and imply that therapeutic targeting of the pathway could act to block PI3K activity in this subset of patients. | SIGNOR-251492 |
P17482 | P78543 | 0 | binding | up-regulates activity | 0.685 | The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. | SIGNOR-220987 |
P19634 | Q13464 | 0 | phosphorylation | up-regulates activity | 0.685 | We then engineered the T653A NHE1 mutant (ROCKA mutant), which can not be phosphorylated by p160ROCK.|p160ROCK has also been shown to activate NHE1 at threonine 653 , in close vicinity to the Akt phosphorylation site at serine 648. | SIGNOR-279566 |
Q8WU20 | P22455 | 0 | phosphorylation | up-regulates activity | 0.685 | In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. | SIGNOR-242661 |
P16157 | O94856 | 0 | relocalization | up-regulates quantity | 0.685 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with ankyrins, a family of spectrin-binding proteins located on the cytoplasmic surface of specialized plasma membrane domains. | SIGNOR-266718 |
Q13561 | O43264 | 0 | relocalization | up-regulates activity | 0.685 | ZW10 interacts with dynamitin, a subunit of the dynein-dynactin complex (Echeverri et al., 1996), thereby recruiting this motor to kinetochores | SIGNOR-265016 |
Q9Y4K3 | O43353 | 0 | binding | up-regulates activity | 0.685 | Binding of bacterial MDP or viral RNA to NOD2 results in the association of RIPK2 with TRAF6 and subsequent activation of TRAF6. | SIGNOR-280456 |
Q13485 | O15198 | 0 | phosphorylation | up-regulates | 0.685 | Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. | SIGNOR-168740 |
P22888 | P01229 | 0 | binding | up-regulates | 0.684 | Hcg is a heterodimeric glycoprotein hormone, consisting of a common? -subunit and a hormone-specific ?-Subunit (2). It binds to the lh receptor (lhr). | SIGNOR-70028 |
P04798 | P35869 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.684 | Kaempferol proved to be capable of inhibiting binding of agonist and agonist-induced formation of the AHR/ARNT DNA-binding complex and upregulation of the AHR target gene, CYP1A1. | SIGNOR-259909 |
Q06124 | P10721 | 0 | phosphorylation | up-regulates activity | 0.684 | SHP2 can be phosphorylated at 2 C-terminal tyrosyl residues by receptor tyrosine kinases, including KIT as well as cytosolic tyrosine kinases, including Src and Abl. The level of tyrosyl phosphorylation of SHP2 has been associated with its recruitment to the receptor.Thus, pharmacologic inhibition of SHP2 phosphatase function might permit SHP2 to return to its inactive conformation resulting in reduced tyrosine phosphorylation. | SIGNOR-256140 |
O00139 | P53350 | 0 | phosphorylation | up-regulates activity | 0.684 | Taken together, KIF2A is phosphorylated at T554 by PLK1 in the subdistal appendages of the mother centriole, which enhances MT depolymerization to disassemble primary cilia in a growth-signal-dependent manner.|Thus, PLK1 and APC/C mediated dual regulation connect the MT depolymerizing activity of KIF2A to a physiological primary cilia disassembly during the proliferative phase. | SIGNOR-278380 |
Q12834 | P24941 | 0 | phosphorylation | down-regulates activity | 0.684 | Here we show that cyclin A2-Cdk2 binds and phosphorylates Cdc20 in interphase and this inhibits APC/C-Cdc20 activity.|Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry. | SIGNOR-279322 |
P11217 | Q16816 | 0 | phosphorylation | up-regulates activity | 0.684 | It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 | SIGNOR-267398 |
P49407 | P12931 | 0 | phosphorylation | down-regulates | 0.684 | Using fluorescently tagged proteins combined with resonance energy transfer and image cross-correlation spectroscopy approaches, we show in live cells that beta2-adaptin phosphorylation is an important regulatory process for the dissociation of beta-arrestin-AP-2 complexes in CCPs. Finally, we show that beta2-adaptin phosphorylation is involved in the early steps of receptor internalization. Our findings not only unveil beta2-adaptin as a new Src target during AT1R internalization, but also support the role of receptor-mediated signaling in the control of clathrin-dependent endocytosis of receptors. | SIGNOR-154564 |
O76075 | P42574 | 0 | cleavage | up-regulates | 0.684 | Casp3_ cleaves the 45 kda subunit at two sites to generate an active factor that produces_ dna_ fragmentation | SIGNOR-47419 |
P14635 | Q13635 | 0 | binding | up-regulates | 0.684 | In addition, we demonstrate that endogenous ptc1 and endogenous cyclin B1 interact in vivo. The findings reported here demonstrate that ptc1 participates in determining the subcellular localization of cyclin B1 and suggest a link between the tumor suppressor activity of ptc1 and the regulation of cell division. Thus, we propose that ptc1 participates in a G2/M checkpoint by regulating the localization of MPF. | SIGNOR-199147 |
P00740 | P38435 | 0 | carboxylation | up-regulates activity | 0.683 | The direct gamma-carboxyglutamic acid analysis and the N-terminal sequence analysis of the myotube-synthesized F.IX demonstrate efficient carboxylation at 11 of 12 γ-carboxyglutamic acid residues. |In previous work54 we have demonstrated that the γ-glutamyl carboxylase is present in skeletal muscle, but at a level only 5% to 10% of that found in the liver. This level of enzyme appears to be sufficient to provide full carboxylation of F.IX synthesized in myotubes|Glu 7, 8, 15, 17, 20, 21, 26, 27, 30, 33, and 36 are each less than 10% of the yield at the previous and subsequent cycles. Only a single γ-carboxylated residue, Gla 40, was not assessed by N-terminal sequencing. | SIGNOR-263687 |
Q9Y243 | Q6ZVD8 | 0 | dephosphorylation | down-regulates activity | 0.683 | The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells. | SIGNOR-248731 |
Q15465 | Q5VTY9 | 0 | palmitoylation | up-regulates | 0.683 | Our molecular analysis of knockout mice deficient in skn, the murine homolog of the drosophila ski gene, which catalyzes hh palmitoylation, and gene-targeted mice producting a non palmitoylated form of shh indicates that hh palmitoylation is essential for its activity as well as the generation of a protein gradient in the developing embryos | SIGNOR-124118 |
P12277 | Q96DX5 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.683 | We demonstrate that creatine kinase B (CKB) interacts with Asb-9 in a specific, SOCS box-independent manner. This interaction increases the polyubiquitylation of CKB and decreases total CKB levels within the cell. The targeting of CKB for degradation by Asb-9 was primarily SOCS box-dependent and suggests that Asb-9 acts as a specific ubiquitin ligase regulating levels of this evolutionarily conserved enzyme. | SIGNOR-271623 |
P10451 | Q8IXL6 | 0 | phosphorylation | down-regulates quantity | 0.683 | OPN phosphorylation by Fam20C decreased OPN secretion, and OPN neutralization reduced Fam20C-deficiency-induced osteoclast differentiation and bone metastasis. | SIGNOR-278936 |
P0DMV9 | Q9UL15 | 0 | binding | down-regulates activity | 0.683 | Here, we show that BAG5, a BAG domain-containing family member, interacts with both Hsp70 and parkin with deleterious functional consequences. Through these interactions, BAG5 inhibits Hsp70 chaperone activity and parkin E3 ubiquitin ligase activity; Thus, BAG5 interacts with Hsp70 in vitro and in vivo, and substitution of select residues within the BAG domains is sufficient to abolish this interaction. | SIGNOR-261197 |
P21580 | Q86VP1 | 0 | binding | up-regulates activity | 0.683 | Tx1bp1 appears to be a novel a20-binding protein which mediate the anti-apoptotic activity of a20; tax1bp1 phosphorylation was pivotal for cytokine-dependent interactions among tax1bp1, a20, itch and rnf11 and downregulation of signaling by the transcription factor nf-Kb. | SIGNOR-69921 |
Q9NQL2 | Q8NFG4 | 0 | gtpase-activating protein | up-regulates activity | 0.683 | The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 [..} RagC/D is a key regulator of the interaction of mTORC1 with the Rag heterodimer and that, unexpectedly, RagC/D must be GDP-bound for the interaction to occur | SIGNOR-256504 |
P17676 | Q15418 | 0 | phosphorylation | up-regulates activity | 0.683 | 13 The data presented support previous findings that C/EBPbeta can be a molecular target of RSK1, 16 but provide the first indication that RSK1 can phosphorylate and activate C/EBPbeta to mediate the IL-6 signalling events in cholangiocarcinoma.|As mentioned above, RSK1 has been shown to activate C/EBPbeta in hepatic stellate cells in an experimental model of liver fibrosis. | SIGNOR-280112 |
P38936 | P31751 | 0 | binding | down-regulates activity | 0.682 | Whereas akt1 phosphorylates p21, inducing its release from cdk2 and cytoplasmic localization as previously described for akt, akt2 binds p21 in the region spanning the t145 site of p21, thus competing with phosphorylation by akt1 and inducing its accumulation in the nucleus. These distinct roles of akt/pkb isoforms in modulating proliferation and p21 have important implications for the development of drugs aimed at inhibiting cancer cell proliferation. | SIGNOR-149705 |
P49815 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.682 | However, AMP-activated protein kinase (AMPK), an essential cellular energy sensor, phosphorylates and activates TSC2 [ xref ]. | SIGNOR-278981 |
P40189 | P26441 | 0 | binding | up-regulates | 0.682 | Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. The dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. Some of these biological activities of il-6 are also often exerted by other cytokines, i.e. Il-11, lif, osm, cntf, and ct-2. | SIGNOR-47991 |
P78352 | Q6PJG9 | 0 | binding | up-regulates activity | 0.682 | SALMs 1-3 contain a C-terminal PDZ-binding motif, which interacts with PSD-95, an abundant postsynaptic scaffolding protein, whereas SALM4 and SALM5 lack PDZ binding. One possibility is that SALM3, which is capable of inducing presynaptic differentiation in contacting axons [19], recruits PSD-95 or SAP102 to the sites of early synaptic adhesion. | SIGNOR-264096 |
Q676U5 | Q9Y239 | 0 | binding | up-regulates activity | 0.681 | By a mechanism independent of the adaptor RIP2 and transcription factor NF-kappaB, Nod1 and Nod2 recruited the autophagy protein ATG16L1 to the plasma membrane at the bacterial entry site. Our results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease. | SIGNOR-252406 |
Q00987 | O15297 | 0 | dephosphorylation | up-regulates | 0.681 | Wip1 interacts with and dephosphorylates mdm2 at serine 395, a site phosphorylated by the atm kinase. Dephosphorylated mdm2 has increased stability and affinity for p53, facilitating p53 ubiquitination and degradation. | SIGNOR-158328 |
P55211 | Q07817 | 0 | binding | down-regulates activity | 0.681 | Bcl2l1 associates with casp9 and apaf-1 in mammalian cells.Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation | SIGNOR-56402 |
P45984 | P28562 | 0 | dephosphorylation | down-regulates | 0.681 | We assayed the relative ability of mkp-2, pac1, and mkp-1 to dephosphorylate erk2 and the other related map kinases, jnk2 and p38. the dual specific phosphatases pac1 and mkp-1 previously have been implicated in the in vivo inactivation of erk or of erk and jnk, respectively. | SIGNOR-40879 |
P02452 | P13497 | 0 | cleavage | up-regulates activity | 0.681 | BMP-1myc Expressed in COS-7 Cells Exhibits Procollagen C-proteinase Activity. Bone morphogenetic protein (BMP)-1, which belongs to the tolloid subgroup of astacin-like zinc metalloproteinases, cleaves the C-propeptides of procollagen at the physiologic site and is, therefore, a procollagen C-proteinase (PCP). Cleavage occurs between a specific alanine or glycine residue (depending on the procollagen chain) and an invariant aspartic acid residue in each of the three chains of procollagen. | SIGNOR-256342 |
P15172 | Q09472 | 0 | acetylation | up-regulates | 0.681 | Our results provide direct evidence that myod acetylation functionally activates the protein and show that both pcaf and cbp/p300 are candidate enzymes for myod acetylation in vivo. | SIGNOR-81053 |
P49815 | P28482 | 0 | phosphorylation | down-regulates activity | 0.681 | Here, we show that Erk may play a critical role in TSC progression through posttranslational inactivation of TSC2. Erk-dependent phosphorylation leads to TSC1-TSC2 dissociation and markedly impairs TSC2 ability to inhibit mTOR signaling, cell proliferation, and oncogenic transformation. |Serine to alanine substitution at S664 or double S664A/S540A mutagenesis resulted in a marked reduction in TSC2 phosphorylation to a similar extent. In contrast, S540A substitution only moderately impaired TSC2 phosphorylation (Figure 3D), corroborating the notion that in vivo S664 is the most relevant residue for Erk-mediated phosphorylation. | SIGNOR-249454 |
P04637 | P21675 | 0 | phosphorylation | down-regulates | 0.681 | Phosphorylation on thr-55 by taf1 mediates degradation of p53 | SIGNOR-123651 |
P04637 | Q05086 | 0 | ubiquitination | down-regulates quantity | 0.681 | E6-AP also directly ubiquitylated p53 in an in vitro ubiquitylation assay.|Our result suggests that E6-AP not only enhances the degradation of p53 but also regulates the neuronal cell growth. | SIGNOR-278681 |
O43524 | Q13043 | 0 | phosphorylation | up-regulates | 0.681 | Bonni and coworkers demonstrated that mst1 can phosphorylate foxo3 (and subsequently, foxo1) principally ser207 (ser212 in foxo1), a conserved site in the forkhead domain. This phosphorylation interdicts 14-3-3 binding, promotes foxo nuclear residence and transcriptional activity. | SIGNOR-178190 |
Q52LA3 | Q13627 | 0 | phosphorylation | up-regulates activity | 0.681 | Here we report that DYRK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is required for DREAM assembly. | SIGNOR-262846 |
P01112 | Q06124 | 0 | dephosphorylation | up-regulates activity | 0.681 | Here we identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and dephosphorylates Ras to increase its association with Raf and activate downstream proliferative Ras/ERK/MAPK signalling. | SIGNOR-252094 |
P19174 | P08631 | 0 | phosphorylation | up-regulates activity | 0.681 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated in cells by any of the src-family PTKs in response to the activation of cell surface receptors. | SIGNOR-249361 |
Q9NWT8 | O14965 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.681 | AIP is phosphorylated on Serine 70 by Aurora‐A but not Aurora‐B and expression of phosphorylation mimic mutant of AIP results in prolonged protein stability compared to unphosphorylatable mutant. Phosphorylation of AIP Prolongs its Protein Stability | SIGNOR-262648 |
P35228 | P12931 | 0 | phosphorylation | up-regulates | 0.681 | We identify human inos residue tyr(1055) as a target for src-mediated phosphorylation. src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells. | SIGNOR-188974 |
Q96T51 | P20338 | 0 | binding | up-regulates activity | 0.68 | Here, we have demonstrated that Rab14 interacts with RUFY1, previously identified as a Rab4 effector, and is required for RUFY1 recruitment onto endosomes and efficient recycling of Tfn.|We also found that enlargement of early endosomes mediated by RUFY1 requires its interaction with Rab4 | SIGNOR-261280 |
P60484 | P68400 | 0 | phosphorylation | down-regulates activity | 0.68 | The C-terminal tail of PTEN is also the target of mutations in tumors. As mentioned, this region contains the main phosphorylation sites mapped to residues Ser362, Thr366, Ser370, Ser380, Thr382, Thr383, and Ser385, and the kinases involved are casein kinase 2 (CK2), GSK3_, LKB1, and MAST.84,97-101 The phosphorylation of the tail has been shown to enhance PTEN stability but at the same time decrease its phosphatase activity | SIGNOR-89830 |
Q9UBU9 | P84103 | 0 | binding | up-regulates | 0.68 | 9g8 and srp20 also enhance the tap rna-binding activity | SIGNOR-178111 |
P41220 | Q13976 | 0 | phosphorylation | up-regulates activity | 0.68 | Thus, PKGI-alpha binds to, phosphorylates and activates RGS-2, attenuating receptor-mediated vascular contraction. | SIGNOR-249241 |
Q9UQC2 | P28482 | 0 | phosphorylation | up-regulates | 0.68 | Phosphorylation of grb2-associated binder 2 on serine 623 by erk mapk regulates its association with the phosphatase shp-2 and decreases stat5 activation.We and others have demonstrated that il-2-induced tyrosine phosphorylation of gab2 and its interaction with its sh2 domain-containing partners, shp-2, p85 pi3k, and crkl (5, 26, 27). we report that pretreatment of kit 225 cells with the mek inhibitor u0126, strongly decreased the characteristic shift of gab2 in response to il-2 and increased gab2/shp-2 association, an effect that could be ascribed to erk phosphorylation of serine 623. | SIGNOR-128727 |
P35568 | P28482 | 0 | phosphorylation | down-regulates activity | 0.68 | Rin beta-cells exposed to high glucose exhibited increased c-jun n-terminal kinase (jnk) and erk1/2 activity, which was associated with increased irs-1 phosphorylation at serine (ser)(307) and ser(612), respectively, that inhibits coupling of irs-1 to the insulin receptor and is upstream of the inhibition of irs-1 tyrosine phosphorylation. | SIGNOR-123173 |
Q99717 | O00238 | 0 | phosphorylation | up-regulates activity | 0.68 | Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. | SIGNOR-255260 |
P62993 | P09619 | 0 | binding | up-regulates | 0.68 | A pathway leading to activation of the gtp-binding protein ras involves the adaptor molecule grb2. Here we show that tyr-716, a novel autophosphorylation site in the pdgf beta-receptor kinase insert, mediates direct binding of grb2 in vitro and in vivo. | SIGNOR-34765 |
P49450 | P06493 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.68 | Here, we report that the phosphorylation of CENP-A Ser68 primes the ubiquitin-proteasome-mediated proteolysis of CENP-A during mitotic phase in human cultured cells.the mitotic CENP-A degradation specifically depends on Cdk1 activity. | SIGNOR-277576 |
P14416 | P62166 | 0 | binding | down-regulates activity | 0.68 | Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism that involves a reduction in D2 receptor phosphorylation. Coimmunoprecipitation experiments from striatal neurons reveal that NCS-1 is found in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 receptor desensitization. | SIGNOR-263964 |
P35241 | Q13464 | 0 | phosphorylation | up-regulates activity | 0.68 | A peak of the phosphopeptide, in which only T573 was phosphorylated, was not detected. Quantitative analyses revealed that _100% of T564, but at most _40% of T573, was phosphorylated when C-rad was incubated with Rho-Kc for 1 h. Then we concluded that the major and primary phosphorylation site of radixin by Rho-kinase was T564 and referred to the Rho-Kcphosphorylated C-rad as T564-phosphorylated C-rad. | In this study, we found that the T564 phosphorylation of radixin markedly suppressed its head-to-tail association. This suggests that the T564-phosphorylation of radixin (and probably also the phosphorylation of ezrin T567 and moesin T558) keeps them open and active. | SIGNOR-248994 |
P19174 | P17948 | 0 | binding | up-regulates | 0.679 | We conclude that both flt-1 and kdr have the potential to signal through plc gamma via phosphotyrosine residues located in juxta-membrane and carboxyl tail regions | SIGNOR-53743 |
P09601 | Q16236 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.679 | In both models, the inducer-modified and Nrf2-bound Keap1 is inactivated and, consequently, newly synthesized Nrf2 proteins bypass Keap1 and translocate into the nucleus, bind to the ARE and drive the expression of Nrf2 target genes such as NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HMOX1), glutamate-cysteine ligase (GCL) and glutathione S transferases (GSTs). | SIGNOR-256276 |
P08559 | Q15119 | 0 | phosphorylation | down-regulates | 0.679 | Mammalian pyruvate dehydrogenase (?2_2) (e1) is regulated by phosphorylation-dephosphorylation, catalyzed by the e1-kinase and the phospho-e1-phosphatase. | SIGNOR-33141 |
P20702 | P05362 | 0 | binding | up-regulates | 0.679 | Using assays to quantify cd11c-mediated cell adhesion, we demonstrate that cd11c recognizes icam-2 and vcam-1. The cd11c-binding site on vcam-1 appears to be different from that used by the integrin alpha4. | SIGNOR-31388 |
P42226 | P17706 | 0 | dephosphorylation | down-regulates activity | 0.679 | These results identify TCPTP as a physiological regulator of STAT6 phosphorylation and suggest that specific increases in TCPTP expression in ABC-like DLBCLs may contribute to the different biological characteristics of these tumors | SIGNOR-235192 |
O75807 | O15105 | 0 | binding | up-regulates | 0.679 | We found smad7 interacts with growth arrest and dna damage protein, gadd34, a regulatory subunit of the protein phosphatase 1 (pp1) holoenzyme, which subsequently recruits catalytic subunit of pp1 (pp1c) to dephosphorylate t?RI. | SIGNOR-121280 |
Q01094 | Q13315 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.679 | Selective induction of e2f1 in response to dna damage, mediated by atm-dependent phosphorylation. We identify a site for atm/atr phosphorylation in the amino terminus of e2f1 and we show that this site is required for atm-mediated stabilization of e2f1. Finally, we also show that e2f1 is required for dna damaged induced apoptosis in mouse thymocytes. | SIGNOR-109416 |
Q99836 | Q9NR96 | 0 | binding | up-regulates activity | 0.678 | To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TLR pathways, is usually considered a part of the TIR domain-containing adaptor protein group | SIGNOR-266742 |
O14640 | O60353 | 0 | binding | up-regulates activity | 0.678 | When canonical wnts bind to their respective fzd receptors, heterotrimeric g-proteins and dsh get activated and lead to the recruitment of axin to the fzd co-receptor lrp. | SIGNOR-198828 |
O75084 | O00755 | 0 | binding | up-regulates activity | 0.678 | Wnt7a-Fzd7 signaling stimulates symmetric stem cell divisions | SIGNOR-255646 |
P35222 | P55286 | 0 | binding | up-regulates activity | 0.678 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265870 |
P52655 | P21675 | 0 | phosphorylation | up-regulates activity | 0.678 | Taf(ii) 250 phosphorylates human transcription factor iia on serine residues important for tbp binding and transcription activity. | SIGNOR-105688 |
P40259 | P07948 | 0 | phosphorylation | up-regulates activity | 0.678 | Y182 of CD79a appears to be the initial and preferred site of Ag receptor phosphorylation by Src family kinases. In vitro, Src family Lyn and Fyn predominantly phosphorylate this residue in CD79a, and Y195 does so in CD79b | SIGNOR-251398 |
O14641 | Q9UP38 | 0 | binding | up-regulates activity | 0.678 | Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. | SIGNOR-258952 |
Q9GZV5 | Q4VCS5 | 0 | relocalization | down-regulates | 0.678 | Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. | SIGNOR-201132 |
P10721 | O14544 | 0 | ubiquitination | down-regulates | 0.678 | Suppressor of cytokine signaling 6 (socs6) is a member of the socs family of e3 ubiquitin ligases that can interact with c-kit and suppress c-kit-dependent pathways. / we demonstrate that socs6 has ubiquitin ligase activity toward c-kit and regulates c-kit protein turnover in cells | SIGNOR-169145 |
Q9HAV5 | Q92838 | 0 | binding | up-regulates | 0.678 | Identification of the major product of the eda gene (ectodysplasin a), a protein belonging to a group of tnf ligands, and molecular cloning of the cdna, encoding its receptor (edar), a member of the tnf receptor family, are presented. The role of an alternative eda receptor, localised on the x chromosome (xedar) in the developmental control of the differentiation of skin appendages, is discussed. | SIGNOR-90040 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.