IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q8TBJ5 | Q16650 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.486 | We found that TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2.|(3) Chromatin immunoprecipitation analysis using TBR1 antibodies showed that TBR1 bound to a conserved region in the Fezf2 gene. | SIGNOR-268967 |
P43243 | P35637 | 0 | relocalization | up-regulates activity | 0.486 | Moreover, FUS interacts with another nuclear matrix-associated protein Matrin3, which is muted in a subset of familial ALS cases and reportedly interacts with TDP-43. Interestingly, ectopic ALS-linked FUS mutant sequestered endogenous Matrin3 and SAFB1 in the cytoplasmic aggregates. | SIGNOR-262822 |
Q07812 | P31749 | 0 | phosphorylation | down-regulates activity | 0.486 | Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophilsWe suggest that Bax is regulated by phosphorylation of Ser(184) in an Akt-dependent manner and that phosphorylation inhibits Bax effects on the mitochondria by maintaining the protein in the cytoplasm, heterodimerized with antiapopt... | SIGNOR-252538 |
P23458 | Q9UHF4 | 0 | binding | up-regulates | 0.486 | Each r1-type chain (il-10r1, il-20r1, il-22r1, ifn-_r1 and ifn-_r1) is associated with jak1 tyrosine kinase and mediates recruitment of a variety of signaling molecules after being phosphorylated on its intracellular domain. | SIGNOR-124486 |
P03372 | P17612 | 0 | phosphorylation | down-regulates | 0.486 | Phosphorylation of human estrogen receptor alpha by protein kinase a regulates dimerizationeralpha is phosphorylated by protein kinase a (pka) on serine-236 within the dna binding domain. Mutation of serine-236 to glutamic acid prevents dna binding by inhibiting dimerization by eralpha | SIGNOR-63984 |
P12931 | P63096 | 0 | binding | up-regulates activity | 0.486 | Here we demonstrate that Galphas and Galphai, but neither Galphaq, Galpha12 nor Gbetay, directly stimulate the kinase activity of downregulated c-Src | SIGNOR-256526 |
Q9Y2T1 | P53350 | 0 | phosphorylation | up-regulates activity | 0.486 | Plk1 phosphorylates axin2 at Ser311. | SIGNOR-277180 |
Q13191 | O43597 | 0 | binding | down-regulates | 0.486 | One function of hspry2 in signaling processes downstream of rtks may be to modulate c-cbl physiological function such as that seen with receptor-mediated endocytosis. | SIGNOR-83507 |
P04150 | P31749 | 0 | phosphorylation | down-regulates | 0.486 | Akt1 impairs glucocorticoid-induced gene expression by direct phosphorylation of nr3c1 at position s134 and blocking glucocorticoid-induced nr3c1 translocation to the nucleus | SIGNOR-252543 |
P13569 | P17612 | 0 | phosphorylation | up-regulates | 0.485 | Cftr, the protein associated with cystic fibrosis, is phosphorylated on serine residues in response to camp agonists. Serines 660, 737, 795, and 813 were identified as in vivo targets for phosphorylation by protein kinase a.mutagenesis of all four sites abolished the response. | SIGNOR-21312 |
P29474 | Q9Y243 | 0 | phosphorylation | up-regulates activity | 0.485 | The phosphorylation of both S617 and S635 have also been shown to promote increased eNOS-derived NO release (Michell et al., 2002). The phosphorylaiton of S617 can be induced by PKA or Akt activity, and may serve to sensitize eNOS to calmodulin binding and modulate the phosphorylation of other eNOS sites | SIGNOR-251626 |
Q99453 | Q96F44 | 0 | ubiquitination | down-regulates | 0.485 | The e3 ubiquitin ligasetrim11mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expandedphox2b. | SIGNOR-195878 |
P36956 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.485 | Importantly, we demonstrate that the mature form of endogenous SREBP1 is phosphorylated on Ser-434. Glycogen synthase kinase-3 phosphorylates Ser-434, and the phosphorylation of this residue is attenuated in response to insulin signaling. Interestingly, phosphorylation of Ser-434 promotes the glycogen synthase kinase-3... | SIGNOR-236667 |
Q15121 | O43464 | 0 | binding | down-regulates | 0.485 | Htra2 promotes cell death by binding and degrading the anti-apoptotic protein pea15 | SIGNOR-126966 |
P35637 | Q99873 | 0 | methylation | down-regulates activity | 0.485 | PRMT1 catalyzes the arginine methylation of Fused in Sarcoma (FUS), an RNA-binding protein that interacts with RALY. We demonstrate that RALY down-regulation decreases protein arginine N-methyltransferase 1 levels, thus reducing FUS methylation. It is known that mutations in the FUS nuclear localization signal (NLS) re... | SIGNOR-262274 |
Q03113 | Q96RI0 | 0 | binding | up-regulates | 0.485 | Upon proteolysis, the newly formed n terminus acts as a tethered ligand that activates the receptor and initiates signaling cascades through multiple g proteins (galfaq, galfai, and galfa12/13). | SIGNOR-196012 |
P30307 | P27448 | 0 | phosphorylation | down-regulates activity | 0.485 | C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Phosphorylation of serine 21 6 promotes 1 4-3-3 binding to Cdc25C and is inhibitory to Cdc25C function. | SIGNOR-250176 |
P35222 | O15111 | 0 | phosphorylation | up-regulates quantity | 0.485 | Interestingly, while IKK2 negatively regulates beta-catenin stability similar to GSK3beta, IKK1 seems to increase beta-catenin protein level and downstream signal, such as cyclin D1 transcription.|These results suggested IKK1 may phosphorylate beta-catenin at different residues and protect it from ubiquitination mediat... | SIGNOR-280230 |
P63000 | P52306 | 0 | binding | up-regulates | 0.485 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171418 |
Q99623 | P31749 | 0 | binding | down-regulates | 0.485 | Akt binds prohibitin 2 and relieves its repression of myod and muscle differentiation | SIGNOR-252541 |
P27695 | P68400 | 0 | phosphorylation | up-regulates activity | 0.485 | Here we demonstrate that APE/Ref-1 is phosphorylated by casein kinase II (CKII). This was shown for both the recombinant APE/Ref-1 protein (Km=0.55 mM) and for APE/Ref-1 expressed in COS cells. Phosphorylation of APE/Ref-1 did not alter the repair activity of the enzyme, whereas it stimulated its redox capability towar... | SIGNOR-250825 |
Q8TDC3 | Q15831 | 0 | phosphorylation | up-regulates | 0.485 | Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1we recently demonstrated that the lkb1 tumour suppressor kinase, in complex with the pseudokinase strad and the scaffolding protein mo25, phosphorylates and activates amp-activated protein kinase (ampk). A total of 12 human kin... | SIGNOR-122413 |
P29992 | P34981 | 0 | binding | up-regulates activity | 0.485 | Binding of TRH to TRH-R1 receptor, which is coupled to Gq/11 protein, activates phospholipase C, mobilizes calcium and activates protein kinase C. | SIGNOR-267201 |
P42338 | Q15303 | 0 | binding | up-regulates | 0.485 | Pi3k is the sole binding partner to six tyrosines of erbb3 and one in erbb4. | SIGNOR-146882 |
O94989 | P29323 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.485 | We have identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor tyrosine kinase triggers Ephexin5 phosphorylation, ubiquitination, and degradation. EphB2 mediates phosphorylation of Ephexin5 at tyrosine-361 | SIGNOR-262864 |
P02452 | P01137 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.485 | COL1A1 expression is regulated by upstream genes and the binding of regulatory elements at multiple binding sites upstream of its promoter. During cancer progression, CAFs reorganize and cross-link COL1A1, which accumulates and stiffens in the tumor stroma [12], [18]. This process may involve fibrogenic factors, especi... | SIGNOR-277678 |
P62841 | Q5S007 | 0 | phosphorylation | up-regulates activity | 0.485 | Taken together, these results suggest that phosphorylation of s15 on T136 by LRRK2 mediates enhanced cap-dependent and cap-independent reporter translation and that a stimulatory effect of LRRK2 on mRNA translation contributes to LRRK2 toxicity. | SIGNOR-279058 |
Q02750 | P00540 | 0 | phosphorylation | up-regulates activity | 0.485 | Our data indicate that Mos activated MEK1 in vitro as well as in vivo by phosphorylating Ser 222. | SIGNOR-260920 |
Q96P48 | Q13882 | 0 | phosphorylation | up-regulates activity | 0.485 | ARAP1 associated with PTK6 in an EGF/EGF receptor (EGFR)-dependent manner. In addition, the SH2 domain of PTK6, particularly the Arg(105) residue that contacts the phosphate group of the tyrosine residue, was essential for the association. Moreover, PTK6 phosphorylated residue Tyr(231) in the N-terminal domain of ARAP1... | SIGNOR-263188 |
P30679 | P32238 | 0 | binding | up-regulates activity | 0.485 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257410 |
Q12972 | P17612 | 0 | phosphorylation | down-regulates activity | 0.484 | NIPP-1 is the RNA-binding subunit of a major species of protein phosphatase-1 in the nucleus. The purified recombinant protein was a potent (Ki = 9.9 +/- 0.3 pM) and specific inhibitor of protein phosphatase-1 and was stoichiometrically phosphorylated by protein kinases A and CK2. At physiological ionic strength, phosp... | SIGNOR-250033 |
P08047 | Q05513 | 0 | phosphorylation | up-regulates | 0.484 | Here we have used a variety of approaches to identify 3 amino acids (thr668, ser670, and thr681) in the zinc finger domain of sp1 that are modified by pkc-zeta angiotensin ii, which activates pkc-? Phosphorylation (at thr410) via the angiotensin ii type 1 receptor, stimulates sp1 phosphorylation and increases sp1 bindi... | SIGNOR-160774 |
P25963 | Q14164 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.484 | The activated ikk complex then phosphorylates ikbalfa (an inhibitor of nf-kb) thereby targeting it for ubiquitination and proteasomal degradation. | SIGNOR-167524 |
O95747 | Q9H4A3 | 0 | phosphorylation | up-regulates | 0.484 | Activation of wnk1 coincides with the phosphorylation and activation of two wnk1 substrates, namely, the protein kinases ste20/sps1-related proline alanine-rich kinase (spak) and oxidative stress response kinase-1 (osr1) | SIGNOR-151659 |
Q8NEB9 | P51149 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.484 | The p150 adapter protein is in a complex with rab7. The hVPS34/p150 complex colocalized with rab7 on late endosomes and hVPS34 activity was dependent on nucleotide cycling of rab7 | SIGNOR-261302 |
P55017 | Q9UEW8 | 0 | phosphorylation | down-regulates activity | 0.484 | SPAK directly phosphorylates NCC and its effects on NCC are universally associated with phosphorylation|This adds to the evidence that SPAK-mediated phosphorylation acts primarily to increase activity of individual cotransporters without affecting the amount of NCC on the surface| the kinase (SPAK) that phosphorylates ... | SIGNOR-264623 |
O95837 | Q9HBW0 | 0 | binding | up-regulates activity | 0.484 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257431 |
P00740 | P03951 | 0 | cleavage | up-regulates activity | 0.484 | Factor XI (FXI) is the zymogen of an enzyme (FXIa) that contributes to hemostasis by activating factor IX.|The characterization of the apple disk structure, and its relationship to the catalytic domain, have provided new insight into the mechanism of FXI activation, the interaction of FXIa with the substrate factor IX,... | SIGNOR-263537 |
O14950 | Q13153 | 0 | phosphorylation | up-regulates activity | 0.484 | It has been shown that PAK1 phosphorylates and activates MLC2, leading to cell motility [ xref ]. | SIGNOR-280053 |
P31749 | P63151 | 0 | binding | down-regulates activity | 0.484 | Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.|Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been ... | SIGNOR-252637 |
P04899 | P61073 | 0 | binding | up-regulates activity | 0.484 | Using this model, we have reported that CXCL12 activates Gi1, Gi2, or Gi3 heterotrimeric G proteins in a concentration-dependent manner | SIGNOR-278103 |
Q16659 | P06493 | 0 | phosphorylation | up-regulates | 0.484 | Using ms analysis, we identified four novel phosphorylation sites, ser684, ser688, thr698 and ser705, located at the extreme c-terminus of erk3. All four sites are followed by a proline residue. We have shown that purified cyclin b-cdk1 (cyclindependent kinase 1) phosphorylates these sitesalanine substitution of the fo... | SIGNOR-164499 |
P14923 | Q9UI47 | 0 | relocalization | up-regulates quantity | 0.484 | Overexpression of CTNNA3 in a CTNNA1 negative colon carcinoma cell line resulted in the reassembly of the adherens and tight junctions through the recruitment of CTNNA3 interacting partners such as E-cadherin, β-catenin, plakoglobin, and ZO-14 | SIGNOR-265494 |
P63027 | Q9Y4I1 | 0 | binding | up-regulates activity | 0.484 | Another potential role of myosin Va in LDCV exocytosis lies in facilitating the formation of the SNARE complex, which is needed for fusion of the vesicle with the plasma membrane. Notably, myosin Va binds to at least two SNARE proteins in a Ca2+-dependent manner: at micromolar Ca2+-levels, it binds to VAMP2 located in ... | SIGNOR-269281 |
P53805 | P49841 | 0 | phosphorylation | up-regulates activity | 0.484 | Consensus phosphorylation sites for p42/44 MAPK and GSK-3 are present in the SP repeat of MCIP1 at serine 112 and serine 108, respectively |Several endogenous proteins are capable of inhibiting the catalytic activity of calcineurin. Modulatory calcineurin interacting protein 1 (MCIP1) is unique among these proteins on ... | SIGNOR-249359 |
P40426 | P17481 | 0 | binding | up-regulates activity | 0.484 | the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. | SIGNOR-223149 |
Q9H1J5 | Q92765 | 0 | binding | down-regulates | 0.484 | We and others demonstrated that fzb-1 blocks wnt-1 and xwnt-8 signaling in xenopus embryos, | SIGNOR-51798 |
Q9BY44 | Q9P2K8 | 0 | phosphorylation | down-regulates activity | 0.484 | Activated GCN2 phosphorylates and inhibits eukaryotic translation initiation factor 2A (eIF2\u03b1), leading to a transient reduction in protein synthesis, while enhancing the translation of ATF4 ( xref ), a transcription factor that activates stress-induced gene expression ( xref \u2013 xref ). | SIGNOR-280005 |
Q99759 | Q6Q0C0 | 0 | binding | up-regulates | 0.484 | Traf7 specifically interacts with and activates mekk3. | SIGNOR-123221 |
Q9NQ66 | P30679 | 0 | binding | up-regulates activity | 0.484 | This suggests that both Gal4 and Gal6 can activate PLC b1. | SIGNOR-278120 |
P30281 | Q9UKC9 | 0 | binding | down-regulates quantity by destabilization | 0.484 | Here, we show that a relatively new E3 ligase component belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family, SCF (FBXL2) , impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation. | SIGNOR-271887 |
P04637 | O43683 | 0 | phosphorylation | up-regulates activity | 0.484 | In addition, purified Bub1 directly phosphorylates p53 on Ser-37 in vitro , possibly inducing cellular senescence [ xref ].|Studies have shown that depletion and inhibition of Aurora A, Aurora B, Plk1, or Bub1 induces cellular senescence or cell death in a p53 dependent or -independent but p73 dependent manner in many ... | SIGNOR-280199 |
O14640 | P34925 | 0 | binding | up-regulates | 0.483 | Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. | SIGNOR-129568 |
P55212 | O60285 | 0 | phosphorylation | down-regulates activity | 0.483 | ARK5 negatively regulates procaspase-6 by phosphorylation at Ser257, leading to resistance to the FasL/Fas system. | SIGNOR-250209 |
P54253 | Q86Y13 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.483 | HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates the... | SIGNOR-272078 |
P50148 | Q9UBY5 | 0 | binding | up-regulates activity | 0.483 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257297 |
P63096 | P14416 | 0 | binding | up-regulates activity | 0.483 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256701 |
Q01094 | P49336 | 0 | phosphorylation | down-regulates | 0.483 | E2F1 activity is also repressed by cyclin-dependent kinase-8 (CDK8), a colorectal oncoprotein. Elevated levels of CDK8 protect beta-catenin/TCF-dependent transcription from inhibition by E2F1. | SIGNOR-181078 |
Q96BY2 | Q9HCM9 | 0 | binding | up-regulates quantity by stabilization | 0.483 | TRIM39 stabilizes MOAP-1 by inhibiting the poly-ubiquitination process of MOAP-1.In this study, we report the identification and characterization of TRIM39 as a binding partner of MOAP-1. TRIM39 is the first regulator of MOAP-1 protein stability identified. | SIGNOR-272911 |
P60953 | Q7Z6J4 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.483 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260552 |
Q9NQ66 | P62873 | 0 | binding | down-regulates | 0.483 | These results indicate that g-protein beta gamma subunits constitute a mechanism by which g-protein mediate a rapid and transient plc- beta 1. | SIGNOR-44369 |
P28907 | P16284 | 0 | binding | up-regulates activity | 0.483 | As a receptor, CD38 interacts with its ligand CD31 [15,16]. CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 130 kDa type I transmembrane glycoprotein that consists of six extracellular immunoglobulin-like homology domains, a 19-residue transmembrane domain, and a 118-residue cytoplasmi... | SIGNOR-264254 |
P30307 | Q8TDC3 | 0 | phosphorylation | down-regulates | 0.483 | Overexpression of hssad1 resulted in an increased phosphorylation of cdc25c on ser-216 in vivo.Phosphorylation of cdc25 triggers cell-cycle arrest by the sequestration of cdc25 by 14-3-3 | SIGNOR-56473 |
Q96GD4 | Q9UKC9 | 0 | binding | down-regulates quantity by destabilization | 0.483 | The SCF complex contains a catalytic core consisting of Skp1, Cullin1, and the E2 ubiquitin-conjugating (Ubc) enzyme and a F box component that acts as a receptor targeting numerous substrates via phosphodegron elicited interactions. our screening studies suggested that FBXL2 also targets Aurora B protein for ubiquitin... | SIGNOR-272097 |
P55771 | Q9UGL1 | 0 | binding | up-regulates activity | 0.483 | Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. In a reporter assay system, PLU-1 has potent transcriptional repression activity. BF-1 and PAX9 also represses transcription in the same assay, but co-expression of PLU-1 with BF-1 or PAX9 si... | SIGNOR-223875 |
Q92934 | P27361 | 0 | phosphorylation | down-regulates | 0.483 | Erk-1 map kinase prevents tnf-induced apoptosis through bad phosphorylation and inhibition of bax translocation in hela cells. | SIGNOR-188172 |
Q9UER7 | O43791 | 0 | ubiquitination | down-regulates quantity | 0.483 | These results suggest that SPOP/Cul3-ubiquitin ligase plays an essential role in the control of Daxx level and, thus, in the regulation of Daxx-mediated cellular processes, including transcriptional regulation and apoptosis. | SIGNOR-268858 |
Q13363 | P31749 | 0 | phosphorylation | down-regulates quantity | 0.483 | Co-expression of Pc2 and Akt1 results in both phosphorylation and ubiquitylation of CtBP1, thereby targeting CtBP1 for degradation.|CtBP1 phosphorylation by Akt1 appears to both decrease dimerization and induce ubiquitylation. | SIGNOR-278304 |
Q04206 | P67775 | 0 | dephosphorylation | down-regulates | 0.483 | Rela was dephosphorylated by a purified pp2a core enzyme, a heterodimer formed by the catalytic subunit of pp2a (pp2ac) and pr65, in a concentration-dependent manner.These data suggest that the constitutive activation of rela in melanoma cells could be due, at least in part, to the deficiency of pp2a, which exhibits de... | SIGNOR-110959 |
Q13616 | P01106 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.483 | Furthermore, c-myc activation can also promote the degradation of p27kip1 protein by directly activating the cul1 gene, which encodes a critical component of the ubiquitin ligase scfskp2 | SIGNOR-102749 |
Q969H0 | Q9NYY3 | 0 | phosphorylation | down-regulates | 0.483 | Plk2 regulates centriole duplication through phosphorylation-mediated degradation of fbxw7 (human cdc4).Plk2 phosphorylates fbxw7 on serine 176 | SIGNOR-196448 |
Q12798 | O43303 | 0 | binding | up-regulates activity | 0.483 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-265966 |
O14672 | Q86UF1 | 0 | binding | up-regulates activity | 0.483 | Using cell biological and biochemical methods, we now show that ADAM10 is docked to junctions by its transmembrane partner Tspan33, whose cytoplasmic C terminus binds to the WW domain of PLEKHA7 in the presence of PDZD11. | SIGNOR-261251 |
Q14527 | Q96EP1 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.482 | CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions. CHFR negatively regulates and ubiquitinates HLTF. Taken together, this is the first report identifying the regulatory mechanism of HLTF by CHFR, suggesting that CHFR-mediated downregulation of HLTF may help protect against cancer. | SIGNOR-271460 |
Q15797 | P12757 | 0 | binding | down-regulates | 0.482 | Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad7 | SIGNOR-195636 |
Q14582 | P61244 | 0 | binding | up-regulates activity | 0.482 | the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT... | SIGNOR-240224 |
Q8TD19 | P06493 | 0 | phosphorylation | up-regulates activity | 0.482 | We now identify Plk1 as Nek9 direct activator and propose a two-step activation mechanism that involves Nek9 sequential phosphorylation by CDK1 and Plk1. while CDK1 activity is necessary for Nek9 phosphorylation in mitosis and the resulting change in electrophoretical mobility, Nek9 Thr210 phosphorylation and mitotic a... | SIGNOR-273889 |
Q6JBY9 | Q16644 | 0 | phosphorylation | down-regulates activity | 0.482 | Human CapZIP was phosphorylated at Ser-179 and Ser-244 by MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) or MAPKAP-K3 in vitro. In the present paper we have identified CapZIP as a protein that is phosphorylated exceptionally rapidly by several SAPKs in vitro (Figure 4), and which is expressed ... | SIGNOR-263082 |
Q08211 | P35637 | 0 | relocalization | down-regulates activity | 0.482 | We found that ALS mutants of FUS co-localized with Caprin-1, DDX3X, and DHX9 in cytoplasmic inclusions that could lead to the mis-regulation of their respective pathways, providing further clues to the mechanism of ALS pathogenesis.|FUS interacting proteins were sequestered into the cytoplasmic mutant FUS inclusions th... | SIGNOR-262810 |
Q969H0 | P06748 | 0 | binding | up-regulates quantity | 0.482 | We report here that NPM regulates turnover of the c-Myc oncoprotein by acting on the F-box protein Fbw7 , a component of the E3 ligase complex involved in the ubiquitination and proteasome degradation of c-Myc. NPM was required for nucleolar localization and stabili- zation of Fbw7 | SIGNOR-245084 |
Q13887 | Q14258 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.482 | The oestrogen-inducible E3 ligase EFP (oestrogen-responsive finger protein) was identified as a key player in oestrogen-mediated degradation of KLF5, as knockdown and overexpression of EFP increased and decreased KLF5 protein levels respectively, and the decrease continued even when protein synthesis was blocked. | SIGNOR-271908 |
O95863 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.482 | ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity. | SIGNOR-279587 |
P63092 | P21918 | 0 | binding | up-regulates activity | 0.482 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256771 |
P40763 | P45984 | 0 | phosphorylation | up-regulates | 0.482 | Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. | SIGNOR-179275 |
P07101 | P27361 | 0 | phosphorylation | up-regulates | 0.482 | In this paper we have studied the phosphorylation and activation of alternatively spliced forms of human th by mapkap kinase-1 , mapkap kinase-2, map kinase, and cam kinase-11 | SIGNOR-34678 |
Q13702 | Q9P2G9 | 0 | binding | down-regulates quantity by destabilization | 0.482 | We found that rapsyn was polyubiquitinated by KLHL8-containing E3 ligase, but not by KEAP1-containing E3 ligase, clearly indicating that rapsyn is a direct substrate of KLHL8-containing E3 ligase in mammals. We next examined the effect of KLHL-8 depletion on the ubiquitination of rapsyn by performing RNAi experiments i... | SIGNOR-271781 |
P11388 | P53350 | 0 | phosphorylation | up-regulates | 0.481 | Here we report that when phosphorylated, ser 1524 of topo iialpha acts as a binding site for the brct domain of mdc1 (mediator of dna damage checkpoint protein-1), thereby recruiting mdc1 to chromatin | SIGNOR-182844 |
Q01970 | P17252 | 0 | phosphorylation | down-regulates | 0.481 | These data establish that direct phosphorylation by pka of ser1105 in the putative g-box of plcbeta3 inhibits galphaq-stimulated plcbeta3 activity. | SIGNOR-58859 |
P00533 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.481 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254699 |
Q04721 | P49841 | 0 | phosphorylation | down-regulates activity | 0.481 | We show that gsk-3beta directly binds at c-terminal of the notch2 ankyrin repeats and phosphorylates thr-2068 and/or ser-2070, thr-2074, and thr-2093. | SIGNOR-101570 |
Q96T58 | P35548 | 0 | binding | up-regulates | 0.481 | Furthermore, in addition to msx2, both tlx1 and nkx2-5 proteins interacted with notch-pathway repressors, spen/mint/sharp and tle1/grg1, representing a potential mechanism for (de)regulation. | SIGNOR-188572 |
Q96N96 | Q96SB3 | 0 | binding | up-regulates activity | 0.481 | Here we show that Asef2, but not Asef, interacts with Neurabin2/Spinophilin, a scaffold protein that binds to Filamentous actin (F-actin). Neurabin2 is required for Asef2-induced filopodia formation. RNA interference experiments showed that Asef2, Neurabin2 and APC are involved in HGF-induced cell migration. Furthermor... | SIGNOR-269174 |
P04150 | Q00535 | 0 | phosphorylation | down-regulates activity | 0.481 | Cdk5 phosphorylated gr at multiple serines, including ser203 and ser211 of its n-terminal domain, and suppressed the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to dna.| the effect of CDK5 on GR-induced transcriptional activity ... | SIGNOR-154405 |
P49711 | Q00341 | 0 | binding | up-regulates activity | 0.481 | Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19. vigilin is present at several known CTCF target sites, such as the promoter regions of c-myc and BRCA1, the locus control region of β-globin, and several regions within the Igf2/H19 locus... | SIGNOR-266693 |
P10243 | Q92793 | 0 | binding | up-regulates activity | 0.481 | CBP co-operates functionally with A-Myb | SIGNOR-240984 |
Q9H0K1 | Q15831 | 0 | phosphorylation | up-regulates | 0.481 | A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold. | SIGNOR-122788 |
P31751 | P62714 | 0 | dephosphorylation | down-regulates | 0.481 | These results confirm that the activity changes observed are achieved by a reversible phosphorylation mechanism, and also argue that pp2a may negatively regulate rac-pk activity in vivo. Dephosphorylation of the activated rac-pk in itro by pp2ac resulted in an 87% reduction of kinase activity | SIGNOR-42123 |
P60568 | Q03060 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.481 | In this study we show that CREM is transcriptionally induced in T cells following stimulation through CD3 and CD28, binds to the IL-2 promoter in vivo, and suppresses IL-2 production. | SIGNOR-261576 |
P38936 | P11309 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.481 | Pim-2 phosphorylation of p21(cip1/waf1) enhances its stability and inhibits cell proliferation in hct116 cellshere we demonstrate that like pim-1, pim-2 also phosphorylates the cell cycle inhibitor p21(cip1/waf1) (p21) on thr145 in vitro and in vivo | SIGNOR-164642 |
P04275 | P09958 | 0 | cleavage | up-regulates activity | 0.481 | Like PACE,PACE4 was able to process pro-vWF to its mature form, and efficient cleavage required both the P4 arginine and the P2 lysine | SIGNOR-260368 |
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