IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P22681 | Q04759 | 0 | phosphorylation | up-regulates activity | 0.355 | PKC-θ-mediated phosphorylation of serine and tyrosine residues of c-Cbl prevents its inhibitory effect. Phosphorylation of c-Cbl by PKC-θ inhibits the recruitment of Sh2-containing proteins and subsequent association of cbl E3 ubiquitin ligase with its target proteins | SIGNOR-274144 |
Q13045 | Q96BR1 | 0 | phosphorylation | up-regulates | 0.355 | Here we show that flii is an in vivo substrate of cisk that functions downstream of pi 3-kinase. Cisk can associate with flii and phosphorylate flii at residues ser(436) and thr(818).We demonstrate here that cisk can enhance er transcription, which is dependent on its kinase activity, and mutation of cisk phosphorylati... | SIGNOR-184688 |
P20618 | Q05086 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.355 | Our experiments collectively suggest that UBE3A stimulates Wnt pathway activation by interacting with, ubiquitinating, and reducing the levels of multiple (PSMB1, PSMC2, PSMD2, and PSMD7) proteasome subunits. | SIGNOR-265131 |
O00159 | P50570 | 0 | binding | up-regulates | 0.355 | Dynamin bind directly to the sh3 domain of myo1e / an intriguing possibility is that binding of dynamin and synaptojanin to myo1e tail may activate motor activity since it has been demonstrated that myo1e atpase activity is autoinhibited by its sh3 domain | SIGNOR-152910 |
Q15080 | Q05655 | 0 | phosphorylation | up-regulates activity | 0.355 | P40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. | SIGNOR-249012 |
O15287 | P06493 | 0 | phosphorylation | up-regulates | 0.355 | S387a mutant abolished fancg fusion protein phosphorylation by cdc2. | SIGNOR-129061 |
Q8IYJ3 | P31749 | 0 | phosphorylation | down-regulates quantity | 0.355 | By mutagenesis analysis and subsequent immunoprecipitation (IP), we established that Akt phosphorylates JFC1 at serine 241. Phosphorylation did not alter the ability of JFC1 to bind to Rab27a. Instead, phosphorylation by Akt dramatically decreased when JFC1 was bound to Rab27a. Finally, we show that as a consequence of... | SIGNOR-273540 |
Q8IUC6 | Q9NWF9 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.355 | Triad3A promotes proteolytic degradation of adapter proteins. A, Triad3A promotes down-regulation of TIRAP, TRIF, and RIP1 proteins. | SIGNOR-271609 |
Q08050 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.355 | GSK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. | SIGNOR-277208 |
Q02779 | Q7Z6J0 | 0 | binding | up-regulates | 0.355 | Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks. | SIGNOR-97003 |
P23769 | P06493 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.355 | GATA2 contains a cell division control protein 4 (Cdc4) phosphodegron (CPD), a consensus motif for ubiquitylation by Fbw7, which includes Thr(176). Ectopic expression of Fbw7 destabilized GATA2 and promoted its proteasomal degradation. Substitution of threonine 176 to alanine in GATA2 inhibited binding with Fbw7, and t... | SIGNOR-276884 |
O75496 | P00519 | 0 | phosphorylation | up-regulates activity | 0.355 | Taken together, suggests that c-Abl binds and phosphorylates geminin on Y150 in G2/M/early G1 phases. | SIGNOR-278505 |
P46527 | Q9Y463 | 0 | phosphorylation | up-regulates | 0.355 | Mirk phosphorylates p27 at ser-10, thus stabilizing p27 and blocking its nuclear export and degradation | SIGNOR-235805 |
P12882 | Q02078 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.355 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238748 |
O94811 | P28482 | 0 | phosphorylation | down-regulates activity | 0.354 | Here we show that TPPP induces tubulin self-assembly into intact frequently bundled microtubules, and that the phosphorylation of specific sites distinctly affects the function of TPPP. The phosphorylation sites Thr(14), Ser(18), Ser(160) for Cdk5; Ser(18), Ser(160) for ERK2, and Ser(32) for PKA were identified by mass... | SIGNOR-262928 |
P78337 | P18031 | 0 | dephosphorylation | down-regulates quantity by destabilization | 0.354 | PTP1B dephosphorylates PITX-1 at Y160, 175 and Y179.|Through directly dephosphorylating PITX-1 at Y160, Y175 and Y179, PTP1B promoted proteasomal degradation of PITX-1, thus leaded in downregulating p120RasGAP and CRC cell survival. | SIGNOR-276973 |
P07910 | P48729 | 0 | phosphorylation | down-regulates | 0.354 | A kinase activity was identified in mouse liver that phosphorylates the acd of hnrnp-c at ser(240) and at two sites at ser(225)-ser(228). The kinase was purified and identified by tandem mass spectrometry as protein kinase ck1alpha (formerly casein kinase 1alpha).hnrnp-c1 that was also modified at the ck1alpha phosphor... | SIGNOR-133528 |
P25963 | P18031 | 0 | dephosphorylation | down-regulates | 0.354 | Ptp1b is able to dephosphorylate phosphorylated-tyr-42 on ikappabalpha | SIGNOR-45004 |
P50616 | P28482 | 0 | phosphorylation | down-regulates | 0.354 | Tob is rapidly phosphorylated at ser 152, ser 154, and ser 164 by erk1 and erk2 upon growth-factor stimulation. | SIGNOR-88720 |
Q8IWB6 | P53350 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.354 | We show that phosphorylation of Tex14 by Plk1 during metaphase is required for proteosome dependent degradation of Tex14 and transition from metaphase to anaphase. Phosphorylation of Tex14 Ser431 by Plk1 promotes Tex14 depletion. | SIGNOR-273529 |
Q9Y613 | Q13976 | 0 | phosphorylation | up-regulates | 0.354 | Pkgi also directly phosphorylates fhod1, and studies with wild-type and mutant fhod1-derived peptides identify ser-1131 in the fhod1 c terminus as the unique pkgi phosphorylation site in fhod1. phosphorylation of three conserved residues within the dad domain activates fhod1 while binding to rac regulates fhod1 subcell... | SIGNOR-123646 |
P18031 | P53350 | 0 | phosphorylation | up-regulates activity | 0.354 | Cdk1-cyclin B1 directly phosphorylates PTP1B at serine 386 in a kinase assay. Recombinant Plk1 phosphorylates PTP1B on serine 286 and 393 in vitro, however, it requires a priming phosphorylation by Cdk1 at serine 386 highlighting a novel co-operation between Cdk1 and Plk1 in the regulation of PTP1B.|Finally, phosphoryl... | SIGNOR-272990 |
Q9ULX9 | P54821 | 0 | binding | down-regulates activity | 0.354 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221890 |
Q9UGL1 | P09874 | 0 | relocalization | up-regulates activity | 0.354 | The mechanism of KDM5B recruitment is quite specific and requires the presence of nucleosomes containing histone variant MacroH2A1.1 and PARylation by PARP1. | SIGNOR-271574 |
Q8N122 | Q9UIK4 | 0 | phosphorylation | down-regulates activity | 0.354 | DAPK2 phosphorylates raptor in vitro on Ser721. | SIGNOR-278243 |
O15119 | Q9Y243 | 0 | phosphorylation | up-regulates activity | 0.354 | We have identified TBX3 as a key substrate of AKT3 in melanomagenesis. we have identified the AKT3 target site at serine residue 720 in the TBX3 protein and show that this site is phosphorylated in vivo. the phosphorylation at S720 promotes TBX3 protein stability, nuclear localization, transcriptional repression of E-c... | SIGNOR-223534 |
Q15648 | P28482 | 0 | phosphorylation | up-regulates | 0.354 | We demonstrate that erk phosphorylates trap220/med1 in vivo at two specific sites: threonine 1032 and threonine 1457. importantly, we found that erk phosphorylation significantly increases the stability and half-life of trap220/med1 in vivo and correlates with increased thyroid hormone receptor-dependent transcription... | SIGNOR-142462 |
P49840 | Q96BR1 | 0 | phosphorylation | down-regulates activity | 0.354 | Phosphorylation of GSK3 by PKB or SGK1 inhibits GSK3 activity|estern blotting using an antibody specific for the PKB/SGK1 consensus phosphorylation site in GSK3a/beta (serine 21 and 9 respectively) revealed an increase in GSK3a/beta phosphorylation in human embryonic kidney 293 (HEK293) cells overexpressing wild type S... | SIGNOR-249165 |
P07550 | P31749 | 0 | phosphorylation | down-regulates | 0.354 | Akt mediates sequestration of the beta(2)-adrenergic receptor in response to insulin. Phosphorylation studies of the c-terminal cytoplasmic domain of the beta(2)-adrenergic receptor by akt in vitro identified ser(345) and ser(346) within a consensus motif for akt phosphorylation. | SIGNOR-252470 |
P24666 | P06239 | 0 | phosphorylation | up-regulates activity | 0.354 | In co-transfected COS cells, Lck and Fyn caused phosphorylation of LMPTP. Most of the phosphate was located at Tyr-131, and some was also located at Tyr-132. Site-directed mutagenesis showed that Tyr-131 is important for the catalytic activity of LMPTP, and that thiophosphorylation of Tyr-131, and to a lesser degree Ty... | SIGNOR-251367 |
Q9ULT6 | Q15262 | 0 | dephosphorylation | up-regulates activity | 0.354 | We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer. | SIGNOR-260110 |
P35228 | P27361 | 0 | phosphorylation | up-regulates | 0.354 | Erk phosphorylated inos on ser745. Mutation of ser745 to ala did not affect basal inos activity but eliminated inos phosphorylation and activation in response to b1r agonist. | SIGNOR-157711 |
Q9UGP5 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.354 | We show that Polλ is efficiently phosphorylated by DNA-PKcs in vitro and predominantly by ATM after DSB induction with ionizing radiation (IR) in vivo. We identify threonine 204 (T204) as a main target for ATM/DNA-PKcs phosphorylation on human Polλ, and establish that its phosphorylation may facilitate the repair of a... | SIGNOR-273836 |
P60953 | A1L390 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.354 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260585 |
Q15185 | P68400 | 0 | phosphorylation | up-regulates | 0.354 | Several lines of evidence suggest that a cpges-activating protein kinase is ck-ii (casein kinase ii). Recombinant cpges was phosphorylated directly by and associated with ck-ii in vitro, resulting in marked reduction of the k m for the substrate pgh2. | SIGNOR-123594 |
P42345 | Q13615 | 0 | null | down-regulates activity | 0.354 | The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity. | SIGNOR-245105 |
P42768 | P68400 | 0 | phosphorylation | up-regulates | 0.354 | Here we identify two phosphorylation sites in the vca domain of wasp at serines 483 and 484. S483 and s484 are substrates for casein kinase 2 in vitro and in vivo. Phosphorylation of these residues increases the affinity of the vca domain for the arp2/3 complex 7-fold and is required for efficient in vitro actin polyme... | SIGNOR-101268 |
Q9Y625 | Q13469 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.354 | NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. | SIGNOR-264021 |
Q04864 | Q14164 | 0 | phosphorylation | up-regulates | 0.354 | The present results demonstrate that ikkepsilon- and tbk1-mediated phosphorylation of crel in the c-terminal td leads to cytoplasmic dissociation of a crel-ikb_ complex and nuclear accumulation of crel. | SIGNOR-148620 |
Q9UBU9 | O94901 | 0 | binding | up-regulates activity | 0.354 | SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1. | SIGNOR-263296 |
P41594 | P05771 | 0 | phosphorylation | up-regulates activity | 0.354 | Thus, we showed that it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation. The Thr-840 residue is important only in that it is permissive for the PKC-dependent phosphorylation of Ser-839. | SIGNOR-249286 |
Q14790 | P29350 | 0 | dephosphorylation | up-regulates activity | 0.354 | Caspase-8 is tyrosine-phosphorylated in freshly isolated neutrophils but spontaneously dephosphorylates in culture, in association with the progression of constitutive apoptosis. Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) ... | SIGNOR-248478 |
Q13586 | Q13153 | 0 | phosphorylation | up-regulates activity | 0.354 | Taken together, our data demonstrate that PAK1 interacts with STIM1 and phosphorylates specific STIM1 cytosolic domains. | SIGNOR-279244 |
O43561 | Q12913 | 0 | dephosphorylation | down-regulates activity | 0.353 | Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation | SIGNOR-248696 |
P40763 | P54762 | 0 | phosphorylation | up-regulates activity | 0.353 | By integrating mouse in vivo and in vitro models with human iPSC derived astrocytes, we provide direct evidence that EphB1 can induce early astrocytic STAT3 activation via ephrin-B1 signalling.|We confirmed that EphB1 activates astrocytes by inducing ephrin-B1 dependent STAT3 phosphorylation. | SIGNOR-279709 |
P43405 | Q96P31 | 0 | binding | up-regulates activity | 0.353 | Tyrosine phosphorylation of SPAP2a by c-Src and in vitro. Tyrosine-phosphorylated SPAP2 is specifically associated with SH2 domain-containing tyrosine kinases Syk and Zap70 and SH2 domain-containing tyrosine phosphatases SHP-1 and SHP-2. Site-specific mutagenesis studies revealed that tyrosyl residues 650 and 662 embed... | SIGNOR-274011 |
Q14344 | P43657 | 0 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257347 |
P08047 | O00571 | 0 | binding | up-regulates activity | 0.353 | DDX3X enhances transcription by interacting with transcription factors to promote their binding to the promoter of the target gene. The best characterized mechanism is its cooperation with the transcription factor SP1. The downstream genes of DDX3X-SP1-mediated transactivation include P21, KRAS, and MDM2 | SIGNOR-269202 |
P40238 | Q8WWM7 | 0 | binding | down-regulates | 0.353 | A2d binds to cytokine receptors mpl and epo-r. A2d is associated with these unoccupied receptorsin vivo,and stimulation with tpo or epo causes the rapid dissociation of a2d from the activated receptor. | SIGNOR-113891 |
Q9NZQ7 | Q8IZR5 | 0 | stabilization | up-regulates quantity by stabilization | 0.353 | Furthermore, the observations that (i) CMTM6 affects PD-L1 protein stability at late time points after biosynthesis; (ii) CMTM6, CMTM4 and PD-L1 interact, as shown by co-immunoprecipitation; and that (iii) CMTM6 is largely located at the cell surface, collectively suggest a model in which CMTM6 interacts with PD-L1 at ... | SIGNOR-274981 |
Q08499 | P28482 | 0 | phosphorylation | down-regulates | 0.353 | Long pde4d forms are inhibited by erk2 phosphorylation | SIGNOR-77574 |
O95997 | P28482 | 0 | phosphorylation | up-regulates | 0.353 | Pttg is phosphorylated in vitro on ser(162) by map kinase and this phosphorylation site plays an essential role in pttg transactivation function. | SIGNOR-79515 |
O60346 | P49841 | 0 | phosphorylation | down-regulates | 0.353 | In addition, we show that the beta-trcp-mediated degradation requires phosphorylation of phlpp1 by casein kinase i and glycogen synthase kinase 3beta (gsk-3beta), and activation of the phosphatidylinositol 3-kinase/akt pathway suppresses the degradation of phlpp1 by inhibiting the gsk-3beta activity. | SIGNOR-188330 |
Q9BRS8 | P31749 | 0 | phosphorylation | up-regulates activity | 0.353 | Akt dependent phosphorylation of LARP6. We provide the first description that LARP6 is phosphorylated at multiple sites and that phosphorylation of S451 is critical to activate the protein in type I collagen biosynthesis. | SIGNOR-277213 |
O75444 | P54821 | 0 | binding | down-regulates activity | 0.353 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221893 |
Q08499-2 | P28482 | 0 | phosphorylation | down-regulates | 0.353 | The pde4d2 isoform is inhibited by erk2 phosphorylation | SIGNOR-77563 |
Q9NZV8 | P21333 | 0 | binding | up-regulates activity | 0.353 | Filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities. | SIGNOR-269003 |
P46937 | P35221 | 0 | binding | down-regulates | 0.353 | The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. | SIGNOR-201173 |
Q02556 | Q06124 | 0 | dephosphorylation | down-regulates activity | 0.353 | We found that Bcr-abl-induced, Shp2 dependent dephosphorylation of Icsbp impaired repression of GAS2 by this transcription factor. | SIGNOR-277173 |
P24941 | P07948 | 0 | phosphorylation | down-regulates activity | 0.353 | We also show that Lyn phosphorylates Tyr15 of Cdk2 and that incubation of Lyn with Cdk2 results in inhibition of Cdk2 activity. | SIGNOR-279204 |
Q05397 | P06213 | 0 | phosphorylation | up-regulates activity | 0.353 | P125(Fak) sequence comprising amino acids 568-582, which contains tyrosines 576 and 577 of the kinase domain regulatory loop, is phosphorylated by the insulin receptor. p125(Fak) phosphorylation by the receptor results in its activation. | SIGNOR-251323 |
P48200 | P06493 | 0 | phosphorylation | down-regulates | 0.353 | Irp2 ser-157 is phosphorylated by cdk1/cyclin b1 during g(2)/m / ser-157 phosphorylation during g(2)/m reduces irp2 rna-binding activity | SIGNOR-179171 |
O60266 | Q13555 | 0 | phosphorylation | down-regulates activity | 0.353 | Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. | Site-directed mutagenesis of a CaM kinase II consensus site (Ser-1076 to Ala-1076) in III-AC greatly reduced Ca2+-stimulated phosphorylation and inhibition of III-AC in vivo. | SIGNOR-250691 |
Q13950 | P28562 | 0 | dephosphorylation | up-regulates activity | 0.353 | In a separate study, MKP-1 was shown to induce osteogenesis by dephosphorylating Ser125 on Runx2 isoform type II (37).|MKP-1 increases RUNX2 activity and downregulates MAPK, cyclin D1 in differentiated osteoblasts inducing growth arrest and mineralization. | SIGNOR-277143 |
P02786 | Q9P0V3 | 0 | binding | down-regulates | 0.353 | Here, we report that ttp (sh3bp4), a sh3-containing protein, specifically regulates the internalization of the transferrin receptor (tfr). / overexpression of ttp specifically inhibits tfr internalization | SIGNOR-142840 |
Q8IZP0 | Q96EV8 | 0 | binding | up-regulates activity | 0.353 | Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Although dysbindin-1, WAVE2 and Abi-1 form a ternary complex, dysbindin-1 promoted the binding of WAVE2 to Abi-1. | SIGNOR-265660 |
P41208 | Q92949 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.353 | FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sp... | SIGNOR-266930 |
P01106 | Q92995 | 0 | deubiquitination | up-regulates quantity by stabilization | 0.353 | In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiq... | SIGNOR-274124 |
P60880 | P17252 | 0 | phosphorylation | up-regulates | 0.353 | Phosphorylation of snap-25 at ser187 mediates enhancement of exocytosis by a phorbol ester in ins-1 cells. | SIGNOR-160313 |
O60602 | Q15139 | 0 | phosphorylation | up-regulates | 0.353 | Pkd phosphorylated the tlr5-derived target peptide in vitro, and phosphorylation of the putative target serine 805 in hek 293t cell-derived tlr5 was identified by mass spectrometry. These results demonstrate that both pkd1 and pkd2 are required for inflammatory responses following tlr2, tlr4, or tlr5 activation, althou... | SIGNOR-154473 |
Q7Z7A1 | Q96ED9 | 0 | binding | up-regulates | 0.353 | Hook2 localizes to the centrosome, binds directly to centriolin/cep110 and contributes to centrosomal function | SIGNOR-150956 |
P31749 | O60858 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.353 | Here, we demonstrate that overexpression of RFP2 in cells induced apoptosis through proteasomal degradation of MDM2 and AKT. We observed that RFP2 formed a complex with MDM2, a negative regulator of the p53 tumor suppressor, and AKT, a regulator of apoptosis inhibition at the cellular level. Additionally, we found tha... | SIGNOR-271852 |
O95837 | P30874 | 0 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256963 |
Q9UBB4 | P53350 | 0 | phosphorylation | down-regulates | 0.353 | Phosphorylation of ataxin-10 by polo-like kinase 1 is required for cytokinesis. Plk1 phosphorylates ataxin-10 at s77 and t82 in vitro. we found that ataxin-10 is ubiquitinated, and is subject to proteasome-dependent degradation, which is delayed in the 2a mutant. We propose a model in which plk1 phosphorylation of atax... | SIGNOR-176122 |
P42226 | P45983 | 0 | phosphorylation | down-regulates | 0.353 | Deactivation of stat6 through serine 707 phosphorylation by jnk. | SIGNOR-170153 |
Q07812 | Q9ULZ3 | 0 | relocalization | up-regulates | 0.353 | Asc directly induces bax-mediated apoptosis. Asc induces the translocation of bax to the mitochondria, bax-dependent cycs release from the mitochondria and casp9 activation. | SIGNOR-149522 |
Q04206 | P35813 | 0 | dephosphorylation | down-regulates activity | 0.353 | 23 Here we show that PPM1A directly dephosphorylated RelA at S536 and S276, with resultant inhibition of NF-kappaB transactivation and decreased expression of target genes, notably including MCP-1 and CCL2.|Taken together, these data suggest that dephosphorylation of S276 by PPM1A may contribute to inhibit RelA transcr... | SIGNOR-276963 |
O95837 | P41146 | 0 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257209 |
Q92974 | Q13153 | 0 | phosphorylation | down-regulates | 0.353 | We identify gef-h1 as a binding target and substrate for p21-activated kinase 1 (pak1), we show that phosphorylation of gef-h1 at ser(885) by pak1 induces 14-3-3 binding to the exchange factor and relocation of 14-3-3 to microtubules. | SIGNOR-187573 |
Q06124 | Q9UJC3 | 0 | binding | down-regulates activity | 0.353 | The protein-tyrosine phosphatase domain and N-terminal SH2 domain of SHP2 directly interacted with Hook1. Down-regulation of Hook1 increased SHP2 activity. These results suggested that Hook1 was an endogenous negative regulator of SHP2 phosphatase activity. | SIGNOR-260642 |
Q13761 | P11309 | 0 | phosphorylation | up-regulates quantity | 0.353 | Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T (H) 2 and T (H) 17 T-cell differentiation.|Pim1 kinase phosphorylates and stabilizes Runx3 and alters its subcellular localization. | SIGNOR-279547 |
Q01151 | Q8TEB7 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.352 | In this study, we show that GRAIL can down-modulate the expression of CD83 (previously described as a cell surface marker for mature dendritic cells) on CD4 T cells. GRAIL-mediated down-modulation of CD83 is dependent on an intact GRAIL extracellular protease-associated domain and an enzymatically active cytosolic RING... | SIGNOR-271850 |
Q9UBE8 | Q9NPG1 | 0 | binding | up-regulates | 0.352 | Upon ligand binding, non-canonical wnt signaling controls tissue polarity and cell movement through the activation of rhoa, c-jun n-terminal kinase (jnk), and nemo-like kinase (nlk) signaling cascades. | SIGNOR-167862 |
P17676 | P23771 | 0 | binding | down-regulates | 0.352 | In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of ga... | SIGNOR-132952 |
P27487 | P51654 | 0 | binding | down-regulates | 0.352 | The interaction occurred with both the glycosylated and unglycosylated forms of gpc3 and led to the inhibition of cd26 peptidase activity. | SIGNOR-155527 |
P55957 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.352 | The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid | SIGNOR-271415 |
O60341 | P17252 | 0 | phosphorylation | up-regulates activity | 0.352 | Together, these data indicate that LPS-induced LSD1 phosphorylation by PKC\u03b1 is required for its interaction with p65 in the nucleus.|We have previously reported that LSD1 is phosphorylated by PKCalpha on serine 112 site, and knockin mice bearing phosphorylation defective Lsd1 SA/SA alleles show altered circadian r... | SIGNOR-279425 |
P06400 | P05771 | 0 | phosphorylation | down-regulates activity | 0.352 | The exact mechanism by which PKCbeta degrades RB is unknown.|To attribute increased RB phosphorylation specifically to PKC\u03b2, we transiently transfected PKC\u03b2 -/- hepatocytes, and reintroduction of PKC\u03b2 specifically resulted in increased in phospho-RB (Ser780) levels, further supporting that PKC\u03b2 phos... | SIGNOR-280083 |
P50616 | P27361 | 0 | phosphorylation | down-regulates | 0.352 | Biochemical analyses have then shown that erk mapk (erk2) and jnk/sapk (jnk2) bind to and phosphorylate tob in vitro. Erk catalyzes the phosphorylation more efficiently than jnk | SIGNOR-88728 |
P35568 | Q02750 | 0 | phosphorylation | down-regulates | 0.352 | Thus, at least three kinases mediate phosphorylation of ser307, including jnk, serine kinases in the pi 3-kinase cascade that are activated byinsulinor igf-1, and mek1-sensitive kinase cascades during tnf-alfa stimulation. | SIGNOR-236611 |
P49715 | P28482 | 0 | phosphorylation | down-regulates | 0.352 | Ccaat/enhancer-binding protein alpha (c/ebpalpha) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes.Here we report that inducers of monocyte differentiation inhibit the alternate cell fate choice, that of granulopoi... | SIGNOR-120566 |
Q15796 | Q15759 | 0 | phosphorylation | down-regulates | 0.352 | Smads can also be phosphorylated in the linker region most prominently by the action of mitogen-activated protein (map) kinaseslinker region phosphorylation can prevent nuclear translocation of smads and inhibit tgf-_ signalling, potentially leading to oncogenesis. | SIGNOR-167848 |
Q92882 | Q15418 | 0 | phosphorylation | down-regulates activity | 0.352 | SH3P2 was phosphorylated on Ser(202) by ribosomal S6 kinase (RSK) in an ERK pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility. | SIGNOR-273838 |
Q99583 | P61244 | 0 | binding | up-regulates activity | 0.352 | the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT... | SIGNOR-240354 |
P31269 | P06748 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.352 | In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the mutant protein (NPM1c); however, it is unknown whether NPM1c is required to maintain the leukemic state. Here, we show that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in immediat... | SIGNOR-260138 |
P0DP24 | P06213 | 0 | phosphorylation | down-regulates | 0.352 | The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecu... | SIGNOR-266320 |
O15027 | P28482 | 0 | phosphorylation | up-regulates activity | 0.352 | Recombinant active ERK2 also phosphorylated Sec16 (XREF_FIG). | SIGNOR-280022 |
O43379 | O14965 | 0 | phosphorylation | up-regulates activity | 0.352 | AURKA activity promotes WDR62 spindle localization|We next purified recombinant full-length WDR62 (GST–WDR62-FL) for in vitro kinase assays with active AURKA and demonstrated that WDR62 was a direct phosphorylation target of AURKA|In addition, our quantitative phosphoproteomic analysis of in-vitro-phosphorylated WDR62 ... | SIGNOR-271713 |
P07550 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.352 | We investigate the role of the beta 2-adrenergic receptor phosphorylation by protein kinase C in this regulatory process. Mutation of the serine-261, -262, -344 and -345 of the beta 2-adrenergic receptor prevented the phorbol-ester-induced phosphorylation of the receptor. This mutation also abolished the phorbol-ester-... | SIGNOR-248855 |
Q96T23 | P53350 | 0 | phosphorylation | up-regulates activity | 0.352 | Moreover, CDK1 phosphorylates RSF1 at Ser1375, and this phosphorylation is necessary for PLK1 recruitment. Subsequently, PLK1 phosphorylates RSF1 at Ser1359, stabilizing PLK1 deposition. | SIGNOR-273590 |
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