IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q8N4X5 | P07949 | 0 | phosphorylation | up-regulates activity | 0.33 | RET/PTC induced robust tyrosine phosphorylation of XB130, which promoted its subsequent association with the p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase). We identified tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85a... | SIGNOR-263192 |
P11274 | P18031 | 0 | dephosphorylation | down-regulates | 0.33 | These results illustrate selectivity in the effects of ptps in a cellular context and suggest that ptp1b may function as a specific, negative regulator of p210 bcr-abl signalling in vivo. | SIGNOR-56818 |
P61006 | Q5S007 | 0 | phosphorylation | up-regulates activity | 0.33 | In a screen for Rab8A kinases we identify TAK1 and MST3 kinases that can efficiently phosphorylate the Switch II residue Threonine72 (Thr72) in a similar manner as LRRK2 in vitro. |Overall our data suggests that the phosphorylation of Rab8A at Ser111 may influence Switch II-binding by regulators, thus disrupting intera... | SIGNOR-260267 |
O14745 | Q15418 | 0 | phosphorylation | up-regulates activity | 0.33 | In summary, these results demonstrate that Ras-RSK1 signaling promotes nuclear localization of EBP50.|Specifically, RSK1 phosphorylates EBP50 at threonine 156 (T156) residue in a cell cycle dependent manner, which is important for nuclear translocation of EBP50 to facilitate cellular proliferation and transformation. | SIGNOR-278290 |
P49674 | Q6ZRV2 | 0 | binding | up-regulates quantity | 0.33 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273764 |
P61026 | Q5S007 | 0 | phosphorylation | down-regulates activity | 0.33 | To investigate whether the phosphorylation of Rab10 by LRRK2 is direct, we performed an in vitro kinase assay using recombinant components. Notably, we found that both wt and LRRK2-G2019S, but neither kinase inactive D1994A mutant nor small molecule-inhibited LRRK2, efficiently phosphorylated Rab10, proving a direct ki... | SIGNOR-261277 |
P68366 | P43405 | 0 | phosphorylation | up-regulates activity | 0.33 | Syk, Activated by Cross-linking the B-cell Antigen Receptor, Localizes to the Cytosol Where It Interacts with and Phosphorylates alpha-Tubulin on Tyrosine | SIGNOR-246626 |
P00748 | P01009 | 0 | binding | down-regulates activity | 0.33 | C1INH is a serine protease inhibitor (serpin) that acts on both the complement pathway and the contact system and is the main inhibitor of the contact system by targeting both FXIIa and PK 9. Additionally, FXIIa can be inhibited by α1‐antitrypsin and plasminogen activator inhibitor‐1 (PAI‐1). | SIGNOR-263515 |
Q99075 | P03956 | 0 | cleavage | up-regulates activity | 0.33 | We have recently reported that HB-EGF is a substrate of MT1-MMP and that removal of the N-terminal fragment of HB-EGFby MT1-MMP converts the former into a hyperactive growthfactor that does not require heparin as a co-factor. | SIGNOR-278096 |
Q9P283 | Q9H334 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.33 | FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells. | SIGNOR-269050 |
O43318 | Q9BXM7 | 0 | phosphorylation | up-regulates activity | 0.33 | PINK1 also enhances the association between TRAF6 and TAK1, phosphorylates TAK1, and stimulates polyubiquitination of TAK1. | SIGNOR-279644 |
P04198 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.33 | Because GSK3\u03b2 phosphorylates Nmyc at T58, we assessed GSK3\u03b2 activation in Dex-treated MB cells. | SIGNOR-279722 |
Q00987 | Q9H0A0 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.33 | NAT10 acetylates p53 at K120 and stabilizes p53 by counteracting Mdm2 action. In addition, NAT10 promotes Mdm2 degradation with its intrinsic E3 ligase activity. | SIGNOR-272405 |
Q13118 | P24941 | 0 | phosphorylation | up-regulates quantity | 0.329 | In this study we have shown that CDK2 phosphorylates KLF10 at residue Ser 206 in vivo and in vitro .|In this study, we have shown that KLF10 protein has tightly controlled expression and that the expression level varies in a cell cycle dependent manner whereby CDK2 up-regulates activity the protein level of KLF10 t... | SIGNOR-278394 |
P08651 | Q9HCE7 | 0 | ubiquitination | down-regulates quantity | 0.329 | In addition, Smurf1 knockdown also blocked the degradation of endogenous NFI-C in response to TGF-beta1 (XREF_FIG).|In particular, Smurf1 and Smurf2 markedly increased the polyubiquitination of NFI-C in the presence of TGF-beta1 (XREF_FIG and XREF_SUPPLEMENTARY). | SIGNOR-278753 |
P15173 | P11802 | 0 | binding | down-regulates | 0.329 | In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. | SIGNOR-176530 |
Q5VUA4 | Q92769 | 0 | binding | up-regulates activity | 0.329 | A central domain of TZF is required for repression of AR-mediated transactivation. The results revealed that HDAC2 was coimmunoprecipitated with TZF (Fig. 6A), These results indicate that AR, TZF and HDAC2 form a ternary complex during the repression of AR-mediated transactivation. | SIGNOR-261188 |
P10636 | Q16512 | 0 | phosphorylation | down-regulates | 0.329 | Phosphorylation of tau is regulated by pknthere is a pkn-specific phosphorylation site, ser-320, in mbdsthus pkn serves as a regulator of microtubules by specific phosphorylation of tau, which leads to disruption of tubulin assembly. | SIGNOR-84958 |
P05023 | P17252 | 0 | phosphorylation | down-regulates activity | 0.329 | Parathyroid hormone (PTH) inhibits Na+,K+-ATPase activity through protein kinase C- (PKC) and extracellular signal-regulated kinase- (ERK) dependent pathways and increases serine phosphorylation of the α1-subunit. These results suggest that PTH regulates Na(+),K(+)-ATPase by PKC and ERK-dependent alpha(1)-subunit phos... | SIGNOR-262941 |
O43318 | P67775 | 0 | dephosphorylation | down-regulates | 0.329 | Our results demonstrate that pp6 specifically down-regulates tak1 through dephosphorylation of thr-187 in the activation loop, which is likely important for suppressing inflammatory responses via tak1 signaling pathways. | SIGNOR-150369 |
Q92598 | P68400 | 0 | phosphorylation | down-regulates activity | 0.329 | Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. | the phosphorylation of Hsp105 alpha at Ser(509) abolished the inhibitory activity of Hsp105 alpha in vitro. | SIGNOR-250901 |
Q13568 | P07948 | 0 | phosphorylation | down-regulates activity | 0.329 | Lyn Kinase Suppresses the Transcriptional Activity of IRF5. Here, we found that Lyn physically interacted with IRF5 to inhibit ubiquitination and phosphorylation of IRF5 in the TLR-MyD88 pathway, thereby suppressing the transcriptional activity of IRF5 in a manner independent of Lyn's kinase activity. | SIGNOR-277247 |
Q8N122 | P53350 | 0 | phosphorylation | up-regulates activity | 0.329 | Of note, MYC-PLK1 (WT) overexpression strongly enhanced MTOR and RPTOR signals in PLK1 IPs, whereas the LAMP2 signal was strongly decreased (XREF_FIG).|Thus, we conclude that PLK1 can directly phosphorylate RPTOR in vitro. | SIGNOR-279346 |
Q96RL1 | P54132 | 0 | binding | up-regulates activity | 0.329 | Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR), controlled by the E3 ligases RNF8/RNF168, triggers BLM recruitment to sites of replication fork stalling via ubiquitylation in the N-terminal region of BLM and subsequent BLM binding to the ubiquitin-interacting motifs of . | SIGNOR-272116 |
Q13422 | P36873 | 0 | dephosphorylation | up-regulates | 0.329 | Ikarosis dephosphorylated by protein phosphatase 1 (pp1) via interaction at a consensus pp1-binding motif/ hyperphosphorylation of ikaros promotes its degradation by the ubiquitin/proteasome pathway | SIGNOR-174865 |
Q07812 | Q9Y371 | 0 | binding | up-regulates | 0.329 | Here, we provide evidence that bif-1 plays a regulatory role in apoptotic activation of not only bax but also bak and appears to be involved in suppression of tumorigenesis. while bif-1 did not directly interact with bak, it heterodimerized with bax on mitochondria in intact cells, and this interaction was enhanced by... | SIGNOR-141166 |
P46937 | P26232 | 0 | binding | down-regulates | 0.329 | The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. | SIGNOR-201245 |
P05107 | Q05655 | 0 | phosphorylation | up-regulates | 0.329 | In this study, we present evidence that pkc isoforms are the major protein kinases that phosphorylate the c terminus of the integrin cd18 chain in leukocytes. Ser-745 is identified as a novel phosphorylation site in the integrin cytoplasmic domain. Additionally, we show that a thr-758-phosphorylated integrin peptide ca... | SIGNOR-178897 |
O14733 | Q7Z6J0 | 0 | binding | up-regulates | 0.329 | We confirmed that posh binds activated rac1 and find that it also binds all mlk family members tested and interacts with mkk4/7 as well as jnk1 and jnk2. | SIGNOR-96955 |
P10415 | Q5S007 | 0 | phosphorylation | up-regulates activity | 0.329 | Thus, we propose that Thr56 phosphorylation of Bcl-2 by LRRK2 G2019S might be a crucial step of mitochondrial disorder, which initiates the subsequent cellular damage in the context of PD relevant to G2019S.|We found that LRRK2 G2019S induced loss of the MMP was recovered in both GFP-Bcl-2 and GFP-M-Bcl-2 stable cells ... | SIGNOR-279531 |
P80188 | O94916 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.329 | As expected, the depletion of NFAT5 decreased the S100A4 and LCN2 mRNA levels (Figure 3a). In addition, chromatin immunoprecipitation (ChIP) assay using NFAT5 antibody indicated that NFAT5 was bound to the S100A4 and LCN2 promoters (Figure 3b, Supplementary Figure S3), as expected (Chen et al., 2009). | SIGNOR-274114 |
P30291 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.329 | Serine 211 phosphorylation occurred under control conditions in the absence of CK1δ and in the presence of GSK3-β (Fig. 5, D and E). | SIGNOR-276632 |
Q9H9S0 | Q02156 | 0 | phosphorylation | up-regulates activity | 0.329 | Taken together, our results demonstrate that PKC\u03b5-mediated phosphorylation at T200 and T280 enhances Nanog protein stability in head and neck squamous cell carcinoma.|These observations confirm that PKCepsilon modulates Nanog transcriptional activity and demonstrate that Nanog is phosphorylated by PKCepsilon at T2... | SIGNOR-278203 |
O94761 | P24941 | 0 | phosphorylation | up-regulates activity | 0.329 | During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs. | SIGNOR-277374 |
Q9UQB3 | P12931 | 0 | phosphorylation | up-regulates activity | 0.329 | Furthermore, according to our data from immunoprecipitation to py20 antibody, c-Src can phosphorylate delta-catenin on Y1073, Y1176, Y1179 and Y1112, with the predominant sites being Y1073, Y1112 and Y1176.|Interestingly, we found that c-Src can increase the stability of delta-catenin in MEF cells. | SIGNOR-278327 |
Q14469 | P17252 | 0 | phosphorylation | down-regulates activity | 0.329 | Endogenous HES-1 DNA-binding activity is post-translationally inhibited during NGF signaling in vivo, and phosphorylation of PKC consensus sites in the HES-1 DNA-binding domain inhibits DNA binding by purified HES-1 in vitro. | SIGNOR-248993 |
Q15910 | Q14680 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.329 | We observed a MELK-mediated increase of EZH2 S220 phosphorylation along with a concomitant loss of EZH2 K222 ubiquitination, suggesting a phosphorylation-dependent regulation of EZH2 ubiquitination. | SIGNOR-277480 |
Q13261 | P43405 | 0 | phosphorylation | up-regulates activity | 0.329 | Mutation of a defined region of the intracellular signaling portion of IL-15Ralpha (Tyr227) abrogates both the IL-15Ralpha/Syk association and IL-15Ralpha phosphorylation. Taken together, this suggests that Syk kinase physically and functionally associates with the IL-15Ralpha chain in B cells and that Syk plays a key ... | SIGNOR-246556 |
Q9Y478 | Q8IYT8 | 0 | phosphorylation | down-regulates | 0.329 | Ulk1/2 in turn phosphorylates all three subunits of ampk and thereby negatively regulates its activity | SIGNOR-173092 |
P23677 | Q9UQM7 | 0 | phosphorylation | up-regulates | 0.329 | D-myo-inositol 1,4,5-trisphosphate 3-kinase a is activated by receptor activation through a calcium:calmodulin-dependent protein kinase ii phosphorylation mechanism. the phosphorylated residue was thr311. | SIGNOR-48387 |
P40763 | P62136 | 0 | dephosphorylation | down-regulates activity | 0.329 | Avicins dephosphorylate Stat3 in a variety of human tumor cell lines, leading to a decrease in the transcriptional activity of Stat3.| However, PD98059, an inhibitor of MEK1/2, had no significant effects on avicin-induced dephosphorylation of Stat3 (Ser 727) | SIGNOR-248563 |
Q9UBF6 | P67870 | 0 | phosphorylation | up-regulates activity | 0.329 | In the present study, we show the evidence that CKBBP1 is phosphorylated on threonine residue at position 10 by CKII in vitro and in vivo. Most importantly, disruption of this phosphorylation in CKBBP1 results in accumulation of IκBα and p27Kip1 in HeLa cells and inhibits cell proliferation that appears to be linked to... | SIGNOR-251081 |
P18433 | Q05655 | 0 | phosphorylation | up-regulates activity | 0.328 | In this process, PTPalpha Ser-180 and Ser-204 phosphorylation is critical for the induction of phosphatase activity, which is required for dephosphorylation of pp60(c-src). Taken together, we demonstrate the physical and functional association between PI 3-kinase, PKCdelta and PTPalpha in a signaling complex that media... | SIGNOR-249113 |
P05771 | Q6ZVD8 | 0 | dephosphorylation | down-regulates quantity | 0.328 | Here we show that the two PHLPP isoforms, PHLPP1 and PHLPP2, also dephosphorylate the hydrophobic motif on PKC betaII, an event that shunts PKC to the detergent-insoluble fraction, effectively terminating its life cycle | SIGNOR-237039 |
Q15172 | P19525 | 0 | phosphorylation | up-regulates | 0.328 | Phosphorylation of serine 28 by pkr promotes mitochondrial localization of b56alpha, because wild-type but not mutant s28a b56alpha promoted mitochondrial pp2a activity. | SIGNOR-181793 |
Q8IV61 | Q04759 | 0 | phosphorylation | up-regulates | 0.328 | Activation of rasgrp3 by phosphorylation of thr-133 is required for b cell receptor-mediated ras activation. our data suggest that pkc, after being activated by diacylglycerol, phosphorylates rasgrp3, thereby contributing to its full activation. | SIGNOR-130490 |
P00533 | Q9BV68 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.328 | RNF126 and Rabring7 associate with the EGFR through a ubiquitin-binding zinc finger domain and both E3 ubiquitin ligases promote ubiquitylation of EGFR. In HeLa cells depleted of either RNF126 or Rabring7 the EGFR is retained in a late endocytic compartment and is inefficiently degraded. | SIGNOR-272103 |
Q9UKV8 | O00743 | 0 | dephosphorylation | up-regulates activity | 0.328 | Our experiments demonstrated that target engagement by AGO2 stimulates its hierarchical, multi-site phosphorylation by CSNK1A1 on a series of highly conserved residues (S824-S834).Although this impairs target binding, dephosphorylation by ANKRD52-PPP6C allows AGO2 to engage new targets. Inactivation of this cycle stron... | SIGNOR-276515 |
P51610 | Q06547 | 0 | binding | down-regulates activity | 0.328 | The C1 factor interacts with the GABP_ transactivation domain.The domain of the C1 factor required for C1GABP interaction can inhibit GABP_dependent transcriptional activation | SIGNOR-221377 |
Q15836 | Q9H6Y7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.328 | Here, we show that Godzilla/RNF167 regulates endosome recycling by the ubiquitylation of VAMP3 on Lys66, Lys68 and Lys77; namely, two adjacent Lys residues on the both sides of the critical interface of SNARE complex are ubiquitylated. In agreement with VAMP3 being a target for Goliath family ubiquitin ligases, we show... | SIGNOR-272093 |
P62745 | O14757 | 0 | phosphorylation | up-regulates activity | 0.328 | We identified that Thr173 and Thr175 of RhoB was phosphorylated by Chk1 using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) (Supplementary Fig.\u00a06f). | SIGNOR-279727 |
Q86UF1 | Q5EBL8 | 0 | binding | up-regulates activity | 0.328 | Using cell biological and biochemical methods, we now show that ADAM10 is docked to junctions by its transmembrane partner Tspan33, whose cytoplasmic C terminus binds to the WW domain of PLEKHA7 in the presence of PDZD11. The PLEKHA7-PDZD11 Complex Clusters ADAM10 at Junctions through Tspan33 | SIGNOR-261252 |
Q15797 | Q9UNE7 | 0 | ubiquitination | down-regulates | 0.328 | These results suggest that chip can interact with the smad1/smad4 proteins and block bmp signal transduction through the ubiquitin-mediated degradation of smad proteins. | SIGNOR-120731 |
P06493 | P19525 | 0 | phosphorylation | down-regulates | 0.328 | Our findings demonstrate that (i) pkr, ser/thr kinase, phosphorylates its new substrate cdc2 at the tyr 4 residue, (ii) pkr-mediated tyr 4-phosphorylation facilitates cdc2 ubiquitination and proteosomal degradation | SIGNOR-164809 |
Q9P2D0 | P05771 | 0 | phosphorylation | down-regulates | 0.328 | We found that ibtk_ is phosphorylated at serines 87 and 90 by pkc on bcr engagement;this phosphorylation causes the dissociation of the btk:ibtk_ complex and allows btk to translocate to the plasma membrane. | SIGNOR-173387 |
O14746 | P49711 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.328 | CTCF binds the proximal exonic region of hTERT and inhibits its transcription | SIGNOR-253832 |
Q9H6Z4 | P51812 | 0 | phosphorylation | up-regulates quantity | 0.328 | RSK phosphorylates RanBP3 at Serine 58 residue in vitro and in vivo.RanBP3 phosphorylation increases its affinity towards Ran | SIGNOR-276148 |
Q14493 | P68400 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.328 | Phosphorylation of Thr61 is necessary for subsequent phosphorylation of Thr60 by CK2 in vitro. Inhibitors of CK2 also prevent degradation of SLBP at the end of S phase. Thus, phosphorylation of Thr61 by cyclin A/Cdk1 primes phosphorylation of Thr60 by CK2 and is responsible for initiating SLBP degradation. | SIGNOR-265260 |
O15516 | Q00535 | 0 | phosphorylation | up-regulates | 0.328 | Cdk5 phosphorylates clock at the thr-451 and thr-461 residues in association with transcriptional activation of clock. | SIGNOR-203227 |
P35968 | P48730 | 0 | phosphorylation | down-regulates activity | 0.328 | CKIdelta phosphorylates VEGFR2 at both DSG and DDTD phosphodegrons to promote its interaction with beta-TRCP1.|In a reciprocal set of experiments, we found that overexpression of CKIdelta markedly decreased the half-life of VEGFR2 (XREF_FIG). | SIGNOR-280235 |
P04004 | P68400 | 0 | phosphorylation | up-regulates activity | 0.328 | Therefore, we expressed Vn in a baculovirus system and show (i) that the CKII phosphorylation of wt-Vn enhances the adhesion of bovine aorta endothelial cells; (ii) that the double mutant T50E/T57E (in which the neutral Thr residues are replaced by the negatively charged Glu residues considered analogs of Thr-P) has a... | SIGNOR-250971 |
P04150 | P20962 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.328 | Macromolecular translocation inhibitor II (MTI-II), which was first identified as an in vitro inhibitor of binding between the highly purified glucocorticoid receptor (GR) and isolated nuclei, is an 11.5-kDa Zn2+-binding protein that is also known as ZnBP or parathymosin. MTI-II Enhances GR-dependent Transcription thro... | SIGNOR-268460 |
Q13562 | P54257 | 0 | binding | up-regulates activity | 0.328 | We identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2). Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 | SIGNOR-234602 |
Q15672 | P27361 | 0 | phosphorylation | up-regulates | 0.328 | Phosphorylation of serine 68 of twist1 by mapks stabilizes twist1 protein and promotes breast cancer cell invasiveness. this ser 68 is phosphorylated by p38, c-jun n-terminal kinases (jnk), and extracellular signal-regulated kinases1/2 in vitro | SIGNOR-173413 |
P36956 | P54646 | 0 | phosphorylation | down-regulates | 0.328 | Here we demonstrate that ampk interacts with and directly phosphorylates sterol regulatory element binding proteins (srebp-1c and -2). Ser372 | SIGNOR-173031 |
P09917 | P27361 | 0 | phosphorylation | up-regulates activity | 0.328 | Intriguingly, a significant difference in the potency of nonredox-type inhibitors (but not of BWA4C) was determined between wild-type 5-LO and the mutant S271A/S663A-5-LO (lacking phosphorylation sites for ERK1/2 and MAPKAPK-2) in HeLa cells. Collectively, our data suggest that compared with Ca2+-mediated 5-LO product ... | SIGNOR-264440 |
P15924 | P17612 | 0 | phosphorylation | down-regulates activity | 0.328 | HeLa cells treated with forskolin indicated that stimulation of protein kinase A in transfected cells could decrease the interaction of DP.AN.SerC23 with keratin IF networks. phosphorylation of Ser-C23 could destabilize interactions that occur either directly through this 20 residue sequence or that are dependent on it... | SIGNOR-250353 |
P04637 | Q92934 | 0 | binding | up-regulates activity | 0.328 | We also demonstrate that bad physically interacts with cytoplasmic p53. bad is able to direct p53 to the mitochondria and forms a p53/bad complex at the mitochondria. the mitochondrial p53/bad complex promotes apoptosis | SIGNOR-149815 |
P29033 | P50570 | 0 | binding | down-regulates | 0.328 | This study identifies dynamin 2 (dyn2) as a cx26 interactor in yeast and mammalian cells / we demonstrate that dyn2 regulates cx26 endocytosis and ubiquitination | SIGNOR-205372 |
P35240 | P17252 | 0 | phosphorylation | down-regulates activity | 0.328 | PKC\u03b1\nnormally phosphorylates and inactivates NF2.|PKCalpha normally phosphorylates and inactivates NF2. | SIGNOR-280081 |
P13861 | O43164 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.328 | Praja2 controls the stability of PKA regulatory subunits. Praja2 ubiquitylates RIIα/β subunits. Subunits | SIGNOR-271856 |
P24941 | P31749 | 0 | phosphorylation | up-regulates | 0.328 | Akt phosphorylates cdk2 at threonine 39 residue both in vitro and in vivo. Although cdk2 threonine 39 phosphorylation mediated by akt enhances cyclin-a binding, it is dispensable for its basal binding and the kinase activity. | SIGNOR-178058 |
P78347 | O60674 | 0 | phosphorylation | up-regulates activity | 0.328 | Jak2 activates tfii-i and regulates its interaction with extracellular signal-regulated kinase the interaction between tfii-i and erk, which is essential for its activity, can be regulated by jak2 through phosphorylation of tfii-i at tyrosine 248 | SIGNOR-235313 |
O15399 | P46934 | 0 | ubiquitination | down-regulates activity | 0.328 | Nedd4 coexpression with GluN2D enhances GluN2D ubiquitination and reduces GluN1/GluN2D NMDA receptor responses.|This suggests that Nedd4 association reduces GluN2D function, mostly likely by promoting GluN2D ubiquitination and internalization. | SIGNOR-278636 |
O95999 | O76064 | 0 | ubiquitination | up-regulates quantity by stabilization | 0.328 | Phosphorylated and ubiquitinated BCL10 is stabilized on the damage sites through binding to and presenting UBC13 to RNF168.|We thus concluded that BCL10 is ubiquitinated mainly with K63-linked ubiquitination by RNF8. | SIGNOR-278778 |
O00716 | O14757 | 0 | phosphorylation | up-regulates | 0.328 | These results suggest that e2f3a is directly phosphorylated by chk kinases and that the phosphorylation of serine 124 is required for the posttranslational induction of e2f3a protein by chemotherapy. | SIGNOR-161758 |
P10721 | Q13191 | 0 | ubiquitination | down-regulates activity | 0.328 | KIT binds to and induces the phosphorylation of Cbl proteins, which in turn act as E3 ligases, mediating the ubiquitination and degradation of KIT and themselves. Tyrosine kinase binding and RING finger domains of Cbl are essential for Cbl-mediated ubiquitination and degradation of KIT. | SIGNOR-260105 |
Q6IE81 | P98161 | 0 | binding | down-regulates quantity by destabilization | 0.328 | Full-length PC1 bound, stabilized and colocalized with Jade-1 and inhibited Jade-1 ubiquitination. Jade-1 ubiquitination was mediated by Siah-1, an E3 ligase that binds PC1. | SIGNOR-272917 |
P0DP25 | O43303 | 0 | binding | up-regulates activity | 0.328 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-266348 |
Q05086 | P17612 | 0 | phosphorylation | down-regulates activity | 0.328 | These data suggest that PKA phosphorylation at T485 inhibits UBE3A ubiquitin ligase activity in cells. | SIGNOR-236899 |
P10275 | Q5VWQ8 | 0 | binding | down-regulates activity | 0.328 | DAB2IP acts as a scaffold protein for PP2A to suppress DHT-elicited S81 phosphorylation of the AR, preventing its nuclear translocation and binding to androgen response elements. In addition, DAB2IP can compete with the AR for binding to c-Src, thus blocking the non-genomic AR pathway | SIGNOR-254758 |
Q9Y6K9 | P09769 | 0 | phosphorylation | down-regulates activity | 0.327 | Either IKKγ/NEMO WT or the Y374F mutant was coexpressed with each member of the Src family protein tyrosine kinases (SF-PTKs) in HEK 293T cells. Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKγ/NEMO undergoes phosphorylation upon TNF-α treatment or Kv... | SIGNOR-276368 |
Q9UER7 | P68400 | 0 | phosphorylation | up-regulates | 0.327 | Daxx-sim is phosphorylated by ck2 kinase at residues s737 and s739. Phosphorylation promotes daxx-sim binding affinity toward sumo-1 over sumo-2/3, causing daxx preference for sumo-1 conjugation and interaction with sumo-1-modified factors. | SIGNOR-173105 |
Q92598 | P19784 | 0 | phosphorylation | down-regulates activity | 0.327 | Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. | the phosphorylation of Hsp105 alpha at Ser(509) abolished the inhibitory activity of Hsp105 alpha in vitro. | SIGNOR-251008 |
P22223 | O00192 | 0 | binding | up-regulates quantity by stabilization | 0.327 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252127 |
P23677 | P17612 | 0 | phosphorylation | up-regulates activity | 0.327 | Two isoforms of the inositol 1,4,5-trisphosphate 3-kinase have been identified, the A form and the B form. phosphorylation of isoform A by the cyclic AMP-dependent protein kinase increased activity 1.5-fold, whereas phosphorylation of isoform B decreased activity by 45%. major phosphorylation sites in the protein are S... | SIGNOR-249994 |
P47712 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.327 | To further evaluate cPLA2 as a candidate substrate for PKCζ, we developed a custom antibody recognizing the cPLA2 T376 phosphorylation site. Specificity was validated in both serum starved/stimulated samples | SIGNOR-277518 |
Q13188 | P35240 | 0 | binding | up-regulates activity | 0.327 | NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. | SIGNOR-261955 |
Q5VWQ8 | Q969H0 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.327 | DAB2IP protein levels can be negatively regulated by the activity of the E3-ubiquitin ligases Fbw7, Skp2, and Smurf1 | SIGNOR-254774 |
Q09472 | P31751 | 0 | phosphorylation | up-regulates | 0.327 | We find that suberoylanilide hydroxamic acid stimulates akt activity, which is required to phosphorylate p300 at ser(1834). Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity | SIGNOR-148987 |
P34925 | Q86YT6 | 0 | ubiquitination | down-regulates | 0.327 | We discovered that ryk both physically and functionally interacts with the e3 ubiquitin ligase mind bomb 1 (mib1).We Found that overexpressed ryk and mib1 colocalized and that the overexpression of mib1 leads to the loss of surface ryk expression. In addition, biochemical studies revealed that mib1 promotes the ubiquit... | SIGNOR-176282 |
O43312 | P48730 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.327 | Mechanistically, we defined that Casein Kinase Iδ (CKIδ) phosphorylates Ser322 to trigger MTSS1's interaction with β-TRCP for subsequent ubiquitination and degradation. | SIGNOR-276611 |
Q9NY61 | P49137 | 0 | phosphorylation | up-regulates | 0.327 | Upon genotoxic stress, aatf is phosphorylated by the checkpoint kinase mk2. Phosphorylation results in the release of aatf from cytoplasmic mrlc3 and subsequent nuclear translocation where aatf binds to the puma, bax and bak promoter regions to repress p53-driven expression of these pro-apoptotic genes. | SIGNOR-191935 |
Q9BXL7 | Q9UNE7 | 0 | ubiquitination | up-regulates activity | 0.327 | Subsequently, the ubiquitination of CARMA1 catalyzed by STUB1 was identified as Lys 27 linked, which is important for CARMA1 mediated NF-kappaB activation. | SIGNOR-278720 |
P85298 | P45983 | 0 | phosphorylation | up-regulates activity | 0.327 | Furthermore, we identify that BPGAP1 (a BCH domain-containing, Cdc42GAP-like Rho GTPase-activating protein) promotes MEK partner 1 (MP1)-induced ERK activation on late endosome through scaffolding MP1/MEK1 complex. This regulatory function requires phosphorylation of BPGAP1 by JNK at its C terminal tail (Ser424) to unl... | SIGNOR-275550 |
Q01995 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.327 | Of the three consensus protein kinase C or casein kinase II phosphorylation sites in SM22, only Ser-181 was readily phosphorylated by protein kinase C in vitro, and such phosphorylation greatly decreased actin binding. | SIGNOR-249061 |
Q15831 | P06241 | 0 | phosphorylation | down-regulates activity | 0.327 | Moreover, Fyn kinase directly phosphorylated LKB1 on tyrosine 261 and 365 residues and mutations of these sites resulted in LKB1 export into the cytoplasm and increased AMPK phosphorylation. | SIGNOR-278477 |
O43504 | Q14765 | 0 | binding | up-regulates activity | 0.327 | It suggests that HBXIP is able to activate S100A4 promoter via interacting with STAT4 in breast cancer cells, leading to the up-regulation of S100A4. here we first report that the transcription factor STAT4 plays a role in regulating S100A4 mediated by HBXIP in breast cancer. | SIGNOR-255247 |
Q9Y5B0 | P67870 | 0 | phosphorylation | down-regulates activity | 0.327 | We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of... | SIGNOR-251064 |
O95947 | O43541 | 0 | binding | down-regulates quantity by destabilization | 0.327 | Smad6 mediates Tbx6 ubiquitination and proteasomal degradation. Tbx6 forms a ternary complex with Smad6 and Smurf1. Here, we report that Tbx6 interacts directly with Smad6, an inhibitory Smad that antagonizes the BMP signal. This interaction is mediated through the Mad homology 2 (MH2) domain of Smad6 and residues 90-... | SIGNOR-272785 |
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