IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P38936 | O43293 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.316 | ZIP kinase phosphorylates p21(WAF1) at Thr145 and alanine-substituted mutations in the p21(WAF1) phosphorylation site alter its ability to be phosphorylated by ZIP kinase. | Transfected ZIPK can promote the phosphorylation of p21(WAF1) at Thr145 in vivo and can increase the half-life of p21(WAF1) | SIGNOR-251085 |
Q2KJY2 | P46934 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.316 | Nedd4 polyubiquitinates Kif26b and thus targets it for degradation via the ubiquitin-proteasome pathway. | SIGNOR-278767 |
O75928 | Q16539 | 0 | phosphorylation | up-regulates activity | 0.316 | The switch between the coactivating and inhibitory actions of PIASxα is controlled, at least in part, through PIASxα phosphorylation. PIASxα is itself phosphorylated by p38 in vitro and in vivo in response to the activation of stress signaling pathways (Figure 2, Figure 3, Figure 4). We identify Ser113 and Ser 116 as t... | SIGNOR-262949 |
P04626 | P30530 | 0 | phosphorylation | down-regulates activity | 0.316 | Blockade of Axl function abrogated phosphorylation of ERBB2 (Her-2 and neu) at the Tyr877 residue, indicative of receptor crosstalk.|We have demonstrated that either pharmacological or genetic inhibition of Axl function abrogates phosphorylation of ERBB2 at the critical Tyr877 residue and sensitizes OE33 cells to lapat... | SIGNOR-280193 |
P35354 | O95644 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.316 | NFAT induces the transcription of the COX2 (cyclo-oxygenase-2) gene incancer cells thereby enhancing invasive migration | SIGNOR-264026 |
Q96EZ8 | O14965 | 0 | phosphorylation | up-regulates activity | 0.316 | We conclude that Aurora-A phosphorylates MCRS1 on Ser35/36 specifically during mitosis. | SIGNOR-278232 |
Q15831 | Q9UKG1 | 0 | binding | up-regulates | 0.316 | In this study, we identified lkb1 as a new binding partner of appl1 and showed that the bar domain of appl1 is involved in this interaction.Here we show that in muscle cells adiponectin and metformin induce ampk activation by promoting appl1-dependent lkb1 cytosolic translocation. Appl1 mediates adiponectin signaling b... | SIGNOR-186065 |
P17661 | Q13464 | 0 | phosphorylation | down-regulates | 0.316 | The sites phosphorylated by Aurora-B; Thr-7/Ser-13/Ser-38 of GFAP, and Thr-16 of desmin are common with those related to Rho-associated kinase (Rho-kinase), which has been reported to phosphorylate GFAP and desmin at cleavage furrow during cytokinesis. Rho-kinase was found to phosphorylate desmin at Thr-16, Thr-75, and... | SIGNOR-100177 |
P10636 | Q16539 | 0 | phosphorylation | up-regulates | 0.316 | A large number of cytosolic proteins can be phosphorylated by p38 mapks, including phospholipase a2, the microtubule-associated protein tau, nhe-1, cyclin d1, cdk inhibitors, bcl2 family proteins, growth factor receptors or keratins. | SIGNOR-166611 |
O15033 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.316 | These experiments suggested that GSK3beta phosphorylation of FIEL1 is required for PIAS4 targeting, and FIEL1 residues P779 and phosphorylated T783 are both required for PIAS4 interaction |FIEL1 T783A mutant overexpression completely failed to decrease PIAS4 protein level. | SIGNOR-275528 |
P56524 | Q04206 | 0 | binding | up-regulates | 0.316 | P65 and histone deacetylases 4 cooperate to inhibit the ability of mef2 factors to induce the klf2 promoter | SIGNOR-138368 |
P33151 | Q9UQB3 | 0 | binding | up-regulates quantity by stabilization | 0.316 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252132 |
P05412 | Q14164 | 0 | phosphorylation | up-regulates activity | 0.316 | Indeed, using an in vitro kinase assay, we demonstrated that both JNK and IKKepsilon phosphorylated c-Jun (XREF_FIG and XREF_SUPPLEMENTARY). | SIGNOR-279621 |
Q12778 | P53350 | 0 | phosphorylation | down-regulates activity | 0.316 | In conclusion, we provide evidence that PLK1-dependent phosphorylation of FOXO1 induces its nuclear exclusion and negatively regulates FOXO1 transcriptional activity in PCa.|We previously demonstrated that PLK1 inhibits the transcriptional activity of FOXO1 by promoting its nuclear exclusion in U2OS cells . | SIGNOR-278269 |
Q12824 | Q96EP1 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.316 | Here we report that CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway, and that SRG3/mBAF155 stabilizes these components by blocking their interaction with CHFR. These results suggest that CHFR enhances the d... | SIGNOR-271458 |
Q9NTG7 | P06493 | 0 | phosphorylation | up-regulates activity | 0.315 | Both SIRT3 T150 and S159 phosphorylated by CDK1 indicates that CDK1-SIRT3 pathway may play a role in the overall mitochondrial protein acetylation involved in mitochondrial homeostasis and apoptosis. | SIGNOR-279395 |
P10644 | Q5VU43 | 0 | binding | up-regulates | 0.315 | Mmgl acts as a dual-specific akap by anchoring pka regulatory isoforms r1a and r2a. | SIGNOR-173769 |
O75592 | P46060 | 0 | relocalization | down-regulates quantity by destabilization | 0.315 | SUMOylated RanGAP1 Inhibits MYCBP2 Activity and Mediates Its Transport to the Nucleus. Surprisingly, we did not find MYCBP2-dependent ubiquitylation of SUMOylated RanGAP1 but instead a strong inhibition of the ubiquitin ligase activity of MYCBP2 in the presence of SUMOylated RanGAP1, as determined by the presence of ub... | SIGNOR-261203 |
P27448 | Q15831 | 0 | phosphorylation | up-regulates activity | 0.315 | Regulation of the wnt signalling component par1a by the peutz-jeghers syndrome kinase lkb1. Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1. Mark3 is activated by phosphorylation on thr-211. | SIGNOR-104059 |
O75460 | P00441 | 0 | binding | up-regulates activity | 0.315 | SOD1mut-induced ER stress |we first examined whether SOD1mut induces ER stress in NSC34 motor neurons, as assessed by band-shift analyses of the ER transmembrane kinase receptors IRE1 and PERK. Adenovirus (Ad)-mediated expression of ALS-linked SOD1mut (SOD1G93A) was detectable within 48 h of infection (Supplemental Fig... | SIGNOR-262786 |
P98177 | Q13627 | 0 | phosphorylation | down-regulates | 0.315 | Additionally, ck1, dyrk1a, and cdk2 also phosphorylate foxos at various sites to inhibit foxos activity | SIGNOR-183677 |
P52948 | Q9HC98 | 0 | phosphorylation | down-regulates activity | 0.315 | To elucidate which of the identified sites can be targeted by CDK1/cyclin B1 and Nek6 in vitro (Figure S1D), we performed phosphorylation reactions using recombinant kinases and unlabeled ATP followed by phosphopeptide mapping (Table S1). MS analysis confirmed phosphorylation of S591 and S822 by Nek6 as well as phospho... | SIGNOR-273893 |
Q99801 | P19784 | 0 | phosphorylation | up-regulates | 0.315 | In vitro kinase assays followed by mass spectrometric analyses demonstrated that ck2 phosphorylated recombinant nkx3.1 on thr89 and thr93. We have also determined that nkx3.1 is degraded primarily through a proteasomal pathway, suggesting that phosphorylation by ck2 protects nkx3.1 from degradation. | SIGNOR-145501 |
Q05195 | Q15418 | 0 | phosphorylation | down-regulates | 0.315 | In this study, we showed that mad1 is a substrate of p90 ribosomal kinase (rsk) and p70 s6 kinase (s6k). Both rsk and s6k phosphorylate serine 145 of mad1 upon serum or insulin stimulation. Ser-145 phosphorylation of mad1 accelerates the ubiquitination and degradation of mad1 through the 26s proteasome pathway | SIGNOR-178586 |
A0AVK6 | O14757 | 0 | phosphorylation | down-regulates activity | 0.315 | Chk1 inhibits the transcriptional repressor function of E2F7 and E2F8 to promote cell cycle progression and prevent apoptosis.|Here, we demonstrate that Chk1 phosphorylates both E2F7 and E2F8 in response to DNA damage. | SIGNOR-279693 |
P49716 | P04150 | 0 | transcriptional regulation | up-regulates quantity | 0.315 | We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPδ; C/EBPδ then binds to PPARγ2 promoter and transactivates PPARγ2 gene expression. | SIGNOR-253061 |
Q96EP0 | Q14790 | 0 | cleavage | down-regulates activity | 0.315 | We show that LUBAC interacted with caspase-1 via HOIP and modified its CARD domain with linear polyubiquitin and that depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in response to inflammasome activation, unlike what is observed in macrophages. Reciprocally, caspase-1, as well a... | SIGNOR-272194 |
P19086 | P35462 | 0 | binding | up-regulates activity | 0.315 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257097 |
Q15746 | Q13464 | 0 | binding | up-regulates | 0.315 | Rock proteins are known to regulate mlc-phosphorylation, and apoptotic cells exhibit a gradual increase in levels of phosphorylated mlc concomitant with rock i cleavage. | SIGNOR-106552 |
P54132 | P33981 | 0 | phosphorylation | up-regulates activity | 0.315 | Moreover, in mitosis, TTK promotes phosphorylation of Bloom syndrome protein (BLM) and subsequent interaction of BLM with PLK1, ensuring accurate chromosome segregation xref .|Moreover, in mitosis, TTK promotes phosphorylation of Bloom syndrome protein and subsequent interaction of Bloom syndrome protein with PLK1, ens... | SIGNOR-280156 |
Q8IVT5 | Q7KZI7 | 0 | phosphorylation | down-regulates activity | 0.315 | In vivo, MARK2 appears to negatively regulate KSR1 in insulin sensitivity.|These data suggest that MARK2 phosphorylates KSR1 on Ser392, which has been shown previously to function as a negative regulatory site xref . | SIGNOR-279343 |
P37802 | O94921 | 0 | phosphorylation | down-regulates activity | 0.315 | This newly identified oncogene–tumor suppressor cascade, where oncogenic PFTK1 inactivates a tumor suppressor gene TAGLN2 via phosphorylation|. Our data therefore underline much importance for S83 and S163 residues on TAGLN2 in its actin-binding capacity. | SIGNOR-265103 |
P38405 | P29274 | 0 | binding | up-regulates activity | 0.315 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256909 |
P35222 | Q9H159 | 0 | binding | up-regulates activity | 0.315 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265858 |
P05556 | Q99704 | 0 | binding | down-regulates activity | 0.315 | Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation | SIGNOR-257669 |
O95837 | P07550 | 0 | binding | up-regulates activity | 0.314 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257192 |
P02818 | P07339 | 0 | cleavage | down-regulates quantity by destabilization | 0.314 | This study has been undertaken to compare the degradation of BGP by the cysteine proteinases cathepsins L, B, H, S, and the aspartic proteinase cathepsin D. Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves o... | SIGNOR-256319 |
P01375 | Q8N6T7 | 0 | deacetylation | up-regulates | 0.314 | Sirt6 regulates tnf-alfa secretion through hydrolysis of long-chain fatty acyl lysine | SIGNOR-201662 |
P35568 | P29376 | 0 | phosphorylation | up-regulates | 0.314 | Recently, we demonstrated that ltk utilizes shc and irs-1 as two major substrates and while both equally activate the ras pathway, only irs-1 suppresses apoptosis of hematopoietic cells. | SIGNOR-49531 |
P10912 | P43378 | 0 | dephosphorylation | down-regulates activity | 0.314 | Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (... | SIGNOR-248505 |
P13674 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.314 | Hypoxia upregulates P4HA1 expression in PDAC PDOs through HIF1α. Our results show that the treatment of PDO4 and PDO11 cells with 10 μmol/L of PX-478 for 24 hours reduced the levels of P4HA1 in hypoxia (Fig. 2F), suggesting P4HA1 expression in hypoxia is regulated by HIF1α expression. | SIGNOR-279840 |
O00418 | Q96QT4 | 0 | phosphorylation | up-regulates activity | 0.314 | TRPM7 interacts with, and phosphorylates mouse eEF2-k at serine site 77 | SIGNOR-277923 |
P53350 | O14757 | 0 | phosphorylation | down-regulates activity | 0.314 | Chk1 directly phosphorylates Plk1 to disturb its interaction with Sgo1. | SIGNOR-277914 |
P04637 | P62136 | 0 | dephosphorylation | down-regulates activity | 0.314 | Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death ... | SIGNOR-248557 |
O00712 | P55317 | 0 | binding | up-regulates | 0.314 | Androgen receptor (ar) action throughout prostate development and in maintenance of the prostatic epithelium is partly controlled by interactions between ar and forkhead box (fox) transcription factors, particularly foxa1./ Foxa1 is capable of bringing ar and nfix into proximity, indicating that foxa1 facilitates the a... | SIGNOR-205027 |
Q00613 | P17612 | 0 | phosphorylation | up-regulates | 0.314 | Protein kinase a binds and activates heat shock factor 1hsf1 binds avidly to the catalytic subunit of pka, (pkac_) and becomes phosphorylated on a novel serine phosphorylation site within its central regulatory domain (serine 320 or s320), both in vitro and in vivo. Intracellular pkac_ levels and phosphorylation of hsf... | SIGNOR-169853 |
O00429 | Q13464 | 0 | phosphorylation | up-regulates activity | 0.314 | We have also previously reported that ROCK1-mediated Drp1S600 phosphorylation resulted in enhanced mitochondrial fission in podocytes | SIGNOR-262549 |
O14950 | Q13418 | 0 | phosphorylation | up-regulates activity | 0.314 | Integrin-linked kinase cdna was cloned, sequenced, expressed in e. coli, and shown to phosphorylate myosin light chain in the absence of ca(2+) at ser(19) and thr(18). Smooth muscle contraction follows an increase in cytosolic Ca(2+) concentration, activation of myosin light chain kinase, and phosphorylation of the 20-... | SIGNOR-106427 |
A7KAX9 | Q13480 | 0 | relocalization | up-regulates | 0.314 | Gc-gap, a rho family gtpase-activating protein that interacts with signaling adapters gab1 and gab2. | SIGNOR-102586 |
Q00536 | P17612 | 0 | phosphorylation | down-regulates | 0.314 | Here, we report that cdk16 is activated by membrane-associated cyclin y (ccny). Treatment of transfected human cells with the protein kinase a (pka) activator forskolin blocked, while kinase inhibition promoted, ccny-dependent targeting of cdk16-green fluorescent protein (gfp) to the cell membrane. Ccny binding to cdk1... | SIGNOR-191623 |
P10828 | Q15643 | 0 | binding | up-regulates | 0.314 | Trip230 binds to rb independently of thyroid hormone while it forms a complex with tr in a thyroid hormone-dependent manner. Ectopic expression of the protein trip230 in cells, but not a mutant form that does not bind to tr, enhances specifically tr-dependent transcriptional activity. | SIGNOR-50421 |
Q14653 | P12931 | 0 | phosphorylation | up-regulates activity | 0.314 | Mechanistically, the progesterone-PGR axis activates SRC, which then mediates phosphorylation of IRF3 at Y107.|Taken together, these results suggest that P4 induces PGR-dependent activation of SRC, which promotes virus-triggered activation of IRF3 as well as induction of downstream antiviral genes.In the above experime... | SIGNOR-279118 |
P27361-3 | P06493 | 0 | phosphorylation | up-regulates activity | 0.314 | We found that CDK1 phosphorylates Ser343 of ERK1c, thereby allowing the binding of phosphorylated ERK1c to a complex that consists of PI4KIIIβ (also known as PI4KB) and the 14-3-3γ dimer (encoded by YWHAB). | SIGNOR-277185 |
Q9Y2R2 | Q05655 | 0 | phosphorylation | down-regulates | 0.314 | We show that lyp is phosphorylated exclusively at ser-35 by pkc both in vitro and in vivo. our data establish a mechanism by which pkc could attenuate the cellular function of lyp, thereby augmenting t cell activation. | SIGNOR-159591 |
P20264 | P49335 | 0 | binding | up-regulates activity | 0.314 | POU proteins (Brain-1, Brain-2, Brain-4 and SCIP) serve as transcriptional transactivators. if they were to form homomeric and heteromeric complexes with each other, depending on the particular combination, they might have different DNA-binding specificities and, thus, activate different genes. | SIGNOR-220127 |
P20393 | Q13901 | 0 | binding | up-regulates activity | 0.314 | SUN-CoR is a protein involved in transcriptional repression by nuclear hormone receptors. The C terminus of SUN-CoR interacts with TR and RevErb in vitro and associates with RevErb in cells, SUN-CoR potentiates repression by both receptors in cells, and the N terminus of SUN-CoR contains an intrinsic repression domain. | SIGNOR-241272 |
Q9Y4X5 | Q13618 | 0 | binding | up-regulates activity | 0.314 | Here, we provide evidence that Ariadne RBR E3 ubiquitin ligases such as TRIAD1 and HHARI can bind and be activated by CRL complexes. Whereas TRIAD1 specifically associates with CUL5–RBX2, HHARI is more promiscuous towards cullin types and associates with RBX1-associated cullins 1, 2, 3, and 4A. Interestingly, both TRIA... | SIGNOR-268846 |
Q14653 | P67775 | 0 | dephosphorylation | down-regulates activity | 0.314 | RACK1 Negatively Regulates the Type I IFN pathway. Here we report that IRF3 is deactivated via dephosphorylation mediated by the serine and threonine phosphatase PP2A and its adaptor protein RACK1. The PP2A-RACK1 complex negatively regulated the IRF3 pathway after LPS or poly(I:C) stimulation or Sendai virus (SeV) inf... | SIGNOR-260944 |
O43257 | Q16539 | 0 | phosphorylation | up-regulates | 0.314 | We show that the srcap subunit named znhit1 or p18(hamlet), which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. Furthermore, p18hamlet was phosphorylated during myoblast differentiation in a p38 mapk-dependent manner (dal testo ... | SIGNOR-165571 |
O43464 | Q07812 | 0 | relocalization | up-regulates | 0.313 | Bax and/or bak-mediated release of pro-apoptotic mediators including smac/diablo and omi | SIGNOR-88590 |
Q9Y4K3 | P36406 | 0 | ubiquitination | up-regulates activity | 0.313 | We show here that the upregulation of NF-kappaB by UL144 is dependent upon cellular tripartite motif 23 (TRIM23) protein. We propose a mechanism by which UL144 activates NF-kappaB through a direct interaction with the cellular protein TRIM23 in a complex containing TRAF6. we propose that TRIM23 mediates TRAF6 autoubiq... | SIGNOR-266655 |
P46531 | Q8NBI6 | 0 | binding | up-regulates | 0.313 | Xxylt1 acts on the xyl1,3glc-o-linked glycan of notch egf domains. | SIGNOR-177745 |
Q6NUN9 | P00519 | 0 | phosphorylation | up-regulates activity | 0.313 | C-Abl-mediated phosphorylation of PARIS at Y137 (within the Krüppel-associated box domain) drives its association with KAP1 and the repression of genes with diverse functions in pathways such as chromatin remodelling and p53-dependent cell death. | SIGNOR-277626 |
P10636 | Q16816 | 0 | phosphorylation | down-regulates activity | 0.313 | Muscle phosphorylase kinase phosphorylates Ser237, Ser262, Ser285, Ser305, and Ser352 of human tau. in vitro phosphorylation of tau on Ser262 alone strongly reduced the ability of tau to bind microtubules whereas the phosphorylation of many Ser/Thr-Pro motif sites of tau showed moderate effects on the binding of tau to... | SIGNOR-250285 |
O75581 | P27361 | 0 | phosphorylation | up-regulates | 0.313 | We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. | SIGNOR-169004 |
P14210 | P03951 | 0 | cleavage | up-regulates activity | 0.313 | the ability of plasma kallikrein and FXIa to activate pro-HGF in vitro raises the possibility that mediators of inflammation and blood coagulation may also regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis.Unlike other known activators, both FXIa and kallikrein processed pro-... | SIGNOR-256515 |
Q12778 | P30304 | 0 | dephosphorylation | up-regulates activity | 0.313 | In this study, we revealed that Cdc25A enhances Foxo1 stability by dephosphorylating Cdk2, and Foxo1 was shown to directly regulate transcription of the metastatic factor MMP1. | SIGNOR-277139 |
P38936 | Q9UHC7 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.313 | Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-dependent degradation. A... | SIGNOR-271845 |
P00748 | P45452 | 0 | cleavage | down-regulates quantity by destabilization | 0.313 | The data presented in this study show for the first time the degradation of Factor XII of the blood clotting system by matrix metalloproteinases. MMP-12, MMP-13, and MMP-14 cleave at Gly376Leu377|However, no activity of Factor XII can be observed after MMPinduced cleavage. | SIGNOR-263609 |
O14965 | P55072 | 0 | binding | down-regulates activity | 0.313 | The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.|We found that UBXN-2 and CDC-48 coimmunoprecipitated with AIR-1 from embryonic extracts | SIGNOR-265044 |
P10912 | Q16829 | 0 | dephosphorylation | down-regulates | 0.313 | Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor. | SIGNOR-104545 |
P78352 | Q12840 | 0 | binding | up-regulates activity | 0.313 | Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions | SIGNOR-264065 |
P05107 | O14713 | 0 | binding | down-regulates activity | 0.313 | Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation | SIGNOR-257649 |
P19086 | P41145 | 0 | binding | up-regulates activity | 0.313 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257105 |
Q14247 | P11362 | 0 | phosphorylation | down-regulates | 0.313 | Cortactin, which is an actin-binding protein that also plays a role in actin cytoskeleton dynamics (45), was phosphorylated on tyr-446 in our assay (by fgfr1).Phosphorylation of these residues attenuates the f-actin cross-linking activity | SIGNOR-98618 |
Q12864 | P20823 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.313 | The present study aims to identify the transcription factors which interact and regulate CDH17 promoter activity that might contribute to the up-regulation of CDH17 gene in human HCC|we identified hepatic nuclear factor 1α (HNF1α) and caudal-related homeobox 2 (CDX2) binding sites at the proximal promoter region which ... | SIGNOR-253970 |
Q01726 | P43250 | 0 | phosphorylation | down-regulates activity | 0.313 | Overexpression of GRK6 Inhibits Agonist-Induced cAMP Production in HBL Human Melanoma Cells, without Affecting MC1R Gene Expression | SIGNOR-252389 |
P30304 | P49841 | 0 | phosphorylation | down-regulates quantity by repression | 0.313 | Here, we report that casein kinase 1 alpha (ck1alpha) phosphorylates cdc25a on both s79 and s82 in a hierarchical manner requiring prior phosphorylation of s76 by chk1 or gsk-3beta. This facilitates beta-trcp binding and ubiquitin-mediated proteolysis of cdc25a | SIGNOR-164742 |
P12830 | O60729 | 0 | dephosphorylation | up-regulates activity | 0.313 | Cdc14B activates APC/C Cdh1 after DNA damage in G2.|Importantly, after DNA damage, thein vivo phosphorylation of wild type Cdh1 - but not that of Cdh1 (4xA) - increased after Cdc14B silencing (XREF_FIG), indicating that in response to genotoxic stress, Cdc14B dephosphorylates Cdh1 on the four sites phosphorylated by Cd... | SIGNOR-277017 |
P26012 | O14713 | 0 | binding | down-regulates activity | 0.313 | Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation | SIGNOR-257667 |
Q9ULV1 | Q6UXX9 | 0 | ubiquitination | down-regulates quantity | 0.313 | Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. | SIGNOR-260117 |
Q9NYY3 | Q13627 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.313 | In the present study, it was demonstrated that dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) interacts with and phosphorylates PLK2 at Ser358. DYRK1A-mediated phosphorylation of PLK2 increases its protein stability. | SIGNOR-277805 |
Q12834 | Q96SN8 | 0 | binding | down-regulates activity | 0.313 | We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint, and is associated with reduced expression of the spindle checkpoint proteins BUBR1 and MAD2 and an increase in chromatin-associated CDC20.|We found that the APC activator CDC20, but not other... | SIGNOR-260311 |
Q15361 | Q9GZV5 | 0 | binding | up-regulates | 0.313 | Taz is a coactivator for pax8 and ttf-1, two transcription factors involved in thyroid differentiation. / we show that this interaction leads to a significant enhancement of the transcriptional activity of pax8 and ttf-1 on the thyroglobulin promoter thus suggesting a role of taz in the control of genes involved in thy... | SIGNOR-182296 |
O15379 | Q6W2J9 | 0 | binding | up-regulates activity | 0.313 | BCoR can interact w Because HDACs appear to be involved in repression by an increasing number of transcriptional repressors, we tested whether BCoR can associate with HDACs. BCoR can interact with HDAC1, HDAC3, and HDAC-B/5 more strongly than with HDAC-A/4, HDAC-C, HDAC-D, and HDAC-E. | SIGNOR-252237 |
Q12972 | P07948 | 0 | phosphorylation | down-regulates activity | 0.312 | Tyrosine phosphorylation of NIPP1 by Lyn was abolished by the Tyr-264 to Asp mutation. | SIGNOR-251405 |
P16220 | P48729 | 0 | phosphorylation | up-regulates | 0.312 | Ser108, ser111 and ser114, located in a region matching the consensus sequence for the casein kinase ii target, were required.These results strongly suggest that the casein kinase ii target region is involved in cell cycle-regulated phosphorylation of the creb protein and also in transcriptional enhancement. | SIGNOR-64258 |
P28329 | Q02156 | 0 | phosphorylation | up-regulates | 0.312 | We show that chat is differentially phosphorylated by protein kinase c (pkc) isoforms on four serines (ser-440, ser-346, ser-347, and ser-476) and one threonine (thr-255). This phosphorylation is hierarchical, with phosphorylation at ser-476 required for phosphorylation at other serines. Phosphorylation at some, but no... | SIGNOR-129312 |
P63096 | P35408 | 0 | binding | up-regulates activity | 0.312 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257032 |
P02751 | P05154 | 0 | binding | down-regulates activity | 0.312 | SERPINA5 inhibits HCC cell migration by directly interacting with fibronectin. SERPINA5 disrupts the fibronectin–integrin β1 signaling pathway. | SIGNOR-265881 |
O95817 | P27361 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.312 | We further demonstrated BAG3, a HSP70 co-chaperone, is a bona fide substrate of SCFFBXO22. FBXO22 mediates BAG3 ubiquitination and degradation that requires ERK-dependent BAG3 phosphorylation at S377. | SIGNOR-277318 |
Q9HAV4 | P27361 | 0 | phosphorylation | down-regulates activity | 0.312 | Here we show that ERK suppresses pre-miRNA export from the nucleus through phosphorylation of exportin-5 (XPO5) at T345/S416/S497. After phosphorylation by ERK, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA loading. | SIGNOR-262985 |
O60885 | P27361 | 0 | null | down-regulates activity | 0.312 | The MYC stabilizing kinase, ERK1, regulates MYC levels directly and indirectly by inhibiting BRD4 kinase activity. | SIGNOR-262048 |
Q8TDZ2 | P00519 | 0 | phosphorylation | up-regulates activity | 0.312 | Biochemical assays revealed Abl phosphorylates Mical to directly amplify Mical Redox-mediated F-actin disassembly.|We now find that the Abl non receptor protein tyrosine kinase and oncoprotein signaling pathway activates Mical to direct multiple cellular effects - including extending and shaping cellular processes, gui... | SIGNOR-279674 |
P14672 | O00141 | 0 | phosphorylation | up-regulates activity | 0.312 | We evaluated the putative role of sgk1 in the modulation of glut4. Coexpression of the kinase along with glut4 in xenopus oocytes stimulated glucose transport. The enhanced glut4 activity was paralleled by increased transporter abundance in the plasma membrane. Disruption of the sgk1 phosphorylation site on glut4 ((s27... | SIGNOR-236653 |
P19086 | P28223 | 0 | binding | up-regulates activity | 0.312 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257021 |
P14136 | Q13464 | 0 | phosphorylation | down-regulates activity | 0.312 | We report here that aurora-b phosphorylates gfap and desmin in vitro, and this phosphorylation leads to a reduction in filament forming ability. The sites phosphorylated by aurora-b;thr-7/ser-13/ser-38 of gfap, and thr-16 of desmin are common with those related to rho-associated kinase (rho-kinase), which has been repo... | SIGNOR-100192 |
P16885 | Q92835 | 0 | dephosphorylation | down-regulates activity | 0.312 | An adaptor protein Dok-3 mediates the suppressive function of LYN. The Dok-3 phosphorylated by LYN upon BCR stimulation forms a complex with GRB2, which allows it to enter into the signalosome and associate with activation of SHIP protein. This translocation facilitates the efficient inhibition of PLCc2 and SYK from ac... | SIGNOR-268455 |
O43684 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.312 | Taken together, we highlight the functional significance of the crosstalk between the kinetochore-oriented signal and double-strand break repair pathways via ATM phosphorylation of Bub3 on Ser135. | SIGNOR-277582 |
Q01974 | P49841 | 0 | phosphorylation | down-regulates activity | 0.312 | We identify ror2 ser 864 as a critical residue phosphorylated by gsk3 and required for noncanonical receptor activation by wnt5a, analogous to the priming phosphorylation of low-density receptor-related protein 6 (lrp6) in response to wnt3a. | SIGNOR-169642 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.