IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P06213 | P43378 | 0 | dephosphorylation | down-regulates | 0.26 | Ectopic expression of ptp-meg2 in cells inhibited insulin-induced phosphorylation of the insulin receptor, while rnai-mediated reduction of ptp-meg2 transcript levels enhanced insulin action | SIGNOR-146676 |
P49841 | Q13976 | 0 | phosphorylation | down-regulates activity | 0.26 | Moreover, PrkG1 inhibits GSK3\u03b2 by binding and directly phosphorylating GSK3\u03b2 at its serine-9 residue (Zhao et al., xref ).|Moreover, PrkG1 inhibits GSK3beta by binding and directly phosphorylating GSK3beta at its serine 9 residue. | SIGNOR-280094 |
Q08209 | Q969Q1 | 0 | ubiquitination | down-regulates quantity | 0.26 | First, downregulation of MuRF1 significantly attenuates degradation of CnA in cardiomyocytes in vitro, indicating that endogenous MuRF1 negatively regulates the stability of CnA in a cell-autonomous manner.|Furthermore, MuRF1 directly ubiquitinated CnA in vitro.|These results suggest that MuRF1 directly polyubiquitinat... | SIGNOR-278736 |
P35398 | P28482 | 0 | phosphorylation | down-regulates | 0.26 | We identified the extracellular signal-regulated kinase 2 (erk-2) as roralpha4 phosphorylating kinase in vitro. The primary sequence of roralpha4 contains an erk-2 recognition motif (p-l-t(128)-p) within the hinge domain, and mutation of thr-128 to ala prevents roralpha4 phosphorylation by erk. The roralpha4-t128a muta... | SIGNOR-154914 |
Q03113 | P32249 | 0 | binding | up-regulates activity | 0.26 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257202 |
P08235 | P34947 | 0 | phosphorylation | down-regulates | 0.26 | We report that GRK5 phosphorylates and inhibits the cardiac MR whereas GRK2 phosphorylates and desensitizes GPER. | SIGNOR-278478 |
P51813 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.26 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254693 |
Q13156 | P54727 | 0 | binding | up-regulates activity | 0.26 | GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). TC-NER is initiated by RNA polymerase stalled at a lesion with the help of TC-NER specific factors CSA, CSB, and XAB2. Both pathways require the core NER factors to complete the excision... | SIGNOR-275701 |
P53667 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.26 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254711 |
Q05655 | P31749 | 0 | phosphorylation | up-regulates activity | 0.26 | Of note, the amino acid sequence adjacent to Ser204 phosphorylation site matches the minimal AKT substrate motif (RxxpS) suggesting that AKT1 could potentially directly regulate PRKCD through phosphorylation.|This integrative analysis allowed us to confirm that the enrichment of PRKCD centered network is likely the res... | SIGNOR-280175 |
Q13501 | Q9Y4E8 | 0 | deubiquitination | down-regulates activity | 0.26 | SQSTM1 Is a Substrate for RNF26 and the DUB USP15. Catalytically competent RNF26 (light red) recruits SQSTM1 (blue) and mediates ubiquitin ligation (red), which serves to attract UBDs of specific vesicle-associated adaptors. Dissociation of the RNF26/SQSTM1 complex, promoted by the DUB USP15 (yellow), releases target v... | SIGNOR-269829 |
P09630 | O15550 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.26 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260028 |
Q9NR30 | Q9NRC8 | 0 | deacetylation | up-regulates activity | 0.26 | Significantly, the activity of DDX21 is regulated by acetylation. Acetylation by CBP inhibits DDX21 activity, while deacetylation by SIRT7 augments helicase activity and overcomes R-loop-mediated stalling of RNA polymerases.|acetylation of K18, K137, and K600 impairs the helicase activity of DDX21. | SIGNOR-275903 |
P35236 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.26 | HePTP is phosphorylated by PKC isozymes at Ser-225 in vitro. While all isozymes phosphorylated Ser-225 predominantly and Ser-113 to a lesser extent (Fig. (Fig.5),5), they differed strikingly in how much 32P they incorporated into HePTP during the 30-min assay. PKC θ was the most efficient, while PKC ζ and PKC μ were c... | SIGNOR-276047 |
P40763 | Q99558 | 0 | phosphorylation | up-regulates activity | 0.26 | Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays.|When we transfected NIK into LNCaP cells, NIK was able to phosphorylate Stat3 at both tyrosine 705 and serine 727 residues ( Fig. 3 A). | SIGNOR-279341 |
Q99814 | P27361 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.26 | The activation of ERK1/2 upon hypoxia promoted HIF-2alpha phosphorylation, enhancing its interaction with USP33.Here, we identified USP33 as essential deubiquitinase that stabilizes HIF-2alpha protein in an ERK1/2-dependent manner to promote hypoxia response in cancer cells. | SIGNOR-277584 |
Q96LC7 | P06239 | 0 | phosphorylation | up-regulates | 0.26 | These results suggest that the tyrosines at positions 597 and 667, contained within itim-like motifs, are likely targets of phosphorylation by several classes of signaling molecules, including lck, jak3, and emt. The tyrosine located at position y691 was also contributing to the phosphorylation of the wild-type siglec ... | SIGNOR-112491 |
P41181 | Q07002 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.26 | CDK18 controls AQP2 through phosphorylation at serine 261 and STUB1-mediated ubiquitination. |We had previously observed that a decrease in the phosphorylation of AQP2 at S261 is associated with a decrease in its poly-ubiquitination and an increase in its abundance | SIGNOR-264562 |
Q9HAW9 | Q99626 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.26 | Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. | SIGNOR-253969 |
Q15672 | P0C2W1 | 0 | binding | down-regulates quantity by destabilization | 0.26 | One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbx... | SIGNOR-272183 |
Q01970 | P17612 | 0 | phosphorylation | down-regulates | 0.26 | These data indicate that pkc and pka act similarly in that they inhibit galpha(q)-stimulated plcbeta(3) as a result of phosphorylation of ser(1105). | SIGNOR-79148 |
Q86UR1 | P04637 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.26 | As a transcription factor, p53 induces several pro-apoptotic Bcl-2 members including Bax, Puma, Noxa and Bid, and represses the transcription of certain anti-apoptotic genes, including those encoding Bcl-2, Bcl-xL and survivin 3_and_5. | SIGNOR-209687 |
O15111 | O00141 | 0 | phosphorylation | up-regulates activity | 0.26 | SGK1 directly phosphorylates IKKalpha at Thr 23 and indirectly activates IKKalpha at Ser 180.|SGK1 directly phosphorylates IKKalpha at Thr-23 and indirectly activates IKKalpha at Ser-180. | SIGNOR-278987 |
Q96E17 | Q9UJD0 | 0 | relocalization | up-regulates activity | 0.26 | N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle | SIGNOR-264380 |
P54253 | O75582 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.26 | In summary, the data from the cell based screen, biochemical studies and genetic interactions strongly suggest that MSK1 phosphorylates ATXN1 and regulates its stability. | SIGNOR-279109 |
P46531 | Q8IUQ4 | 0 | relocalization | up-regulates | 0.26 | The overexpression of siah1 causes the re-localization of notch from the cell surface to the cytoplasm and to the nucleus, which is indicative of notch activation | SIGNOR-168460 |
Q15067 | Q9NXA8 | 0 | catalytic activity | down-regulates activity | 0.26 | SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation. | SIGNOR-261210 |
Q6VAB6 | P16298 | 0 | dephosphorylation | up-regulates activity | 0.259 | These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 | SIGNOR-248381 |
P49675 | P01100 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. | SIGNOR-254878 |
Q6VAB6 | P48454 | 0 | dephosphorylation | up-regulates activity | 0.259 | These findings indicate that calcineurin modulates the phosphorylation state of KSR2, but not KSR1, and identifies S198, T287, and the S310 14-3-3 binding site as the KSR2 residues targeted by calcineurin.|the negative regulators 14-3-3 | SIGNOR-248527 |
P49736 | P68400 | 0 | phosphorylation | up-regulates | 0.259 | In this work, by in vitro kinase reactions and mass spectrometry analysis of the products, we have mapped phosphorylation sites in the n terminus of mcm2 by cdc7, cdk2, cdk1, and ck2 | SIGNOR-144004 |
P10275 | P16591 | 0 | phosphorylation | up-regulates | 0.259 | Fer is required for il-6 mediated ar activation by phosphorylating ar tyrosine 223 and binding via its sh2 domain. | SIGNOR-194749 |
P01024 | P17676 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor | SIGNOR-261927 |
P41229 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271564 |
O14733 | P21333 | 0 | binding | up-regulates activity | 0.259 | We used Filamin-A-deficient cells to show that Filamin A enhances MKK7 activation and is important for synergistic stress-induced JNK activation in vivo. Thus Filamin A is a novel member of the group of scaffold proteins whose function is to link two MAPKKs together and promote JNK activation. The present study provide... | SIGNOR-260628 |
P12931 | Q9Y2J4 | 0 | binding | up-regulates activity | 0.259 | These data support an idea that Amotl2 Tyr-103 can be phosphorylated by FGF receptor tyrosine kinase activity. We then determined whether Amotl2 Tyr-103 is required for its interaction with c-Src. |Amotl2 promotes MAPK/ERK activation via c-Src, which is dependent on phosphorylation of tyrosine residue at position 103 b... | SIGNOR-271870 |
Q9NVD7 | P28482 | 0 | phosphorylation | up-regulates activity | 0.259 | Actopaxin (alpha-parvin) is a paxillin, integrin-linked kinase, and F-actin binding focal adhesion protein with several serine phosphorylation sites in the amino terminus that contribute to the regulation of cell spreading and migration.|Actopaxin phosphorylation of Ser4/8 enhances cell migration whereas a nonphosphory... | SIGNOR-265759 |
P03372 | Q00526 | 0 | phosphorylation | up-regulates activity | 0.259 | CDK3 was shown to be overexpressed in breast cancer and phosphorylate ERα at Ser104/116 and Ser118. Furthermore, we found that Mir-873 inhibits ER activity and cell growth via targeting CDK3 | SIGNOR-273187 |
P35637 | P00533 | 0 | phosphorylation | up-regulates activity | 0.259 | Thus, EGFR appears to mediate FUS nuclear translocation by phosphorylating Y6 and Y296 in FUS. | SIGNOR-279168 |
Q92915 | P49841 | 0 | phosphorylation | up-regulates activity | 0.259 | Our laboratory has also demonstrated that FGF14 is a key accessory protein that binds to the intracellular Nav1.6 C-terminal tail, and that GSK3β can phosphorylate FGF14 both in vitro and in vivo at S226 [20] in an experimental model of Alzheimer's disease | SIGNOR-275746 |
P54132 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.259 | We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequen... | SIGNOR-276906 |
Q16665 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.259 | In conclusion, we obtained compelling evidence that CDK5 directly stabilizes the transcription factor hypoxia inducible factor-1\u03b1 by phosphorylation, and thus promotes the formation of blood vessels.|Mass spectrometry and site directed mutagenesis revealed a stabilizing phosphorylation of HIF-1\u03b1 at Ser687 by ... | SIGNOR-279020 |
Q01105-2 | P19784 | 0 | phosphorylation | down-regulates | 0.259 | Ckii-mediated phosphorylation at ser9 hinders nuclear import of set | SIGNOR-200802 |
P12830 | P49674 | 0 | phosphorylation | down-regulates activity | 0.259 | Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts|CK1 colocalizes with E-cadherin and phosphorylates the cytoplasmic domain of E-cadherin in vitro and in a cell culture system. We show that the major CK1 phosphorylation site of E-cadherin is serine 846 | SIGNOR-274047 |
P46527 | O15297 | 0 | dephosphorylation | down-regulates activity | 0.259 | Increased expression of wildtype WIP1 reduces stability of p27 Kip1 while increased expression of similar amounts of phosphatase-dead WIP1 has no effect on p27 Kip1 protein stability.|We demonstrate that wildtype, but not phosphatase-dead WIP1, efficiently dephosphorylates p27 Kip1 Ser140 both in vitro and in cells and... | SIGNOR-277109 |
Q9ULB1 | Q9NR48 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.259 | Our results reveal that a novel process of activity-dependent transcriptional repression exists in neurons and that Ash1L mediates the long-term repression of nrxn1α, thus implicating an important role for epigenetic modification in brain functioning. | SIGNOR-269056 |
Q86VB7 | P69905 | 0 | binding | up-regulates activity | 0.259 | These data suggest that hemoglobin may mediate a stimulatory effect on erythropoiesis through the activation of CD163 on hematopoietic progenitor cells. | SIGNOR-251747 |
P45985 | Q9UL54 | 0 | binding | up-regulates activity | 0.259 | Immunoprecipitated psk phosphorylates myelin basic protein and transfected psk stimulates mkk4 and mkk7 and activates the c-jun n-terminal kinase mitogen-activated protein kinase pathway. | SIGNOR-74864 |
Q9BZL4 | P54646 | 0 | phosphorylation | down-regulates | 0.259 | Ampk-induced phosphorylation is necessary for ppp1r12c interaction with 14-3-3 and phosphorylation of myosin regulatory light chain. Both ampk activity and ppp1r12c phosphorylation are increased in mitotic cells and are important for mitosis completion. The interaction between ppp1r12c and 14-3-3_ may inactivate the pp... | SIGNOR-195148 |
P32243 | P14652 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively | SIGNOR-261634 |
P02511 | P05549 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | Aberrant expression of CRYAB has been shown to be associated with several neurological diseases and malignant neoplasms. To identify transcriptional regulators of CRYAB expression, we examined its promoter for binding sites of transcription factors and identified four potential AP-2 binding sites in addition to a p53 b... | SIGNOR-253636 |
P21333 | Q08209 | 0 | dephosphorylation | down-regulates | 0.259 | We report that a purified c-terminal recombinant region of filamin is a suitable substrate for calcineurin in vitro. Furthermore, 1 microm cyclosporin a (csa), a specific calcineurin inhibitor, reduced the dephosphorylation of the recombinant fragment in 293ft cells | SIGNOR-143979 |
O60341 | Q04759 | 0 | phosphorylation | down-regulates activity | 0.259 | Inhibiting PKC-theta also increased the H3K4 demethylase activity of LSD1, indicating that active PKC-theta may prevent LSD1 from demethylating H3K4 and subsequently causing gene repression.|PKC-theta directly phosphorylates LSD1 at serine 111 and regulates its repressive activity and nuclear localization. | SIGNOR-279104 |
O14920 | P62714 | 0 | dephosphorylation | down-regulates activity | 0.259 | Permanent activation of the upstream kinase IKK beta results from UVB-induced inhibition of the catalytic subunit of Ser-Thr phosphatase PP2A (PP2Ac), leading to immediate phosphorylation and degradation of newly synthesized I kappaB alpha|Chronic Ser 177/181 phosphorylation of IKKβ was due to UVB-induced inhibition of... | SIGNOR-248580 |
P40763 | P23470 | 0 | dephosphorylation | up-regulates activity | 0.259 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254729 |
P63096 | P21452 | 0 | binding | up-regulates activity | 0.259 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256736 |
Q96CW1 | Q5S007 | 0 | phosphorylation | up-regulates activity | 0.259 | These data confirmed that LRRK2 phosphorylates AP2M1 at Thr 156 in vitro. | SIGNOR-278183 |
P15173 | O43257 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | We show that the srcap subunit named znhit1 or p18hamlet, which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. We also show that p18hamlet is required for h2a.z accumulation into this genomic region and for subsequent muscle gene... | SIGNOR-165613 |
P01019 | P24158 | 0 | cleavage | up-regulates activity | 0.259 | Cathepsin G, elastase, and proteinase 3 are serine proteinases released by activated neutrophils. Cathepsin G can cleave angiotensinogen to release angiotensin II, but this activity has not been previously reported for elastase or proteinase 3. In this study we show that elastase and proteinase 3 can release angiotensi... | SIGNOR-256314 |
P25963 | Q9HC78 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.259 | ChIP and next generation high-throughput DNA sequencing assay showed that ZBTB20 specifically bound to IκBα gene promoter (+1 to +60 region) after TLR activation. ZBTB20 could inhibit IκBα gene transcription, govern IκBα protein expression, and then promote NF-κB activation. Therefore, transcriptional repressor ZBTB20 ... | SIGNOR-266868 |
Q14118 | Q12955 | 0 | relocalization | up-regulates quantity | 0.259 | We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4. | SIGNOR-266714 |
P14618 | Q00534 | 0 | phosphorylation | down-regulates activity | 0.259 | Here, using human cancer cells and patient-derived xenografts in mice, we show that the cyclin D3-CDK6 kinase phosphorylates and inhibits the catalytic activity of two key enzymes in the glycolytic pathway, 6-phosphofructokinase and pyruvate kinase M2. | SIGNOR-279158 |
P35498 | Q92914 | 0 | binding | down-regulates activity | 0.259 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253422 |
P00519 | P49759 | 0 | phosphorylation | down-regulates | 0.259 | Here, we identify clk1, clk4, mst1, mst2 and ttk (also known as mps1) as novel thr735 kinases in vitro / phosphorylation of thr735 in c-abl is critical for binding to 14-3-3 | SIGNOR-181031 |
Q9UPW6 | Q99717 | 0 | transcriptional regulation | up-regulates quantity | 0.259 | Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation | SIGNOR-268939 |
P35247 | P49715 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.259 | Cotransfection of C/EBPalpha, C/EBPbeta, or C/EBPdelta cDNA in H441 lung adenocarcinoma cells significantly increased the luciferase activity of a wild-type SP-D promoter construct containing 698 bp of upstream sequence (SS698). Transfection of C/EBP also increased the level of endogenous SP-D mRNA in H441 cells| Thus,... | SIGNOR-254042 |
Q9NRC8 | Q96LA8 | 0 | methylation | down-regulates activity | 0.259 | Protein arginine methyltransferase 6 (PRMT6) directly interacts with and methylates SIRT7 at R388 in vitro and in vivo R388 methylation suppresses the H3K18 deacetylase activity of SIRT7 without modulating its subcellular localization. | SIGNOR-275888 |
Q04637 | P17252 | 0 | phosphorylation | up-regulates activity | 0.258 | Phospho-proteomic and mutational analyses revealed that eIF4G1 is a substrate for PKCα at Ser1186. | SIGNOR-276327 |
P07900 | P05129 | 0 | phosphorylation | down-regulates | 0.258 | Threonine residue set, thr(115)/thr(425)/thr(603), of hsp90_ is specifically phosphorylated by pkc_phosphorylation of hsp90_ by pkc_ decreases the binding affinity of hsp90_ towards atp and co-chaperones such as cdc37 (cell-division cycle 37), thereby decreasing its chaperone activity. | SIGNOR-202812 |
P31644 | Q8TAB3 | 0 | binding | up-regulates quantity by stabilization | 0.258 | Here, we found that PCDH19 binds the alpha subunits of GABAAR and regulates its surface availability and currents in cultured hippocampal neurons. The PCDH19 gene (Xp22.1) encodes the cell-adhesion protein protocadherin-19 (PCDH19) and is responsible for a neurodevelopmental pathology characterized by female-limited ep... | SIGNOR-267219 |
P09874 | Q00535 | 0 | phosphorylation | down-regulates activity | 0.258 | These results would suggest that the phosphorylation of PARP-1 via Cdk5's kinase activity is necessary for its persistence at damage sites.Based on these results and the recruitment data, we hypothesize that the phosphorylation of the PARP-1 protein by Cdk5 on one or more of the serines 782, 785, and 786 results in an ... | SIGNOR-276359 |
P35226 | Q9Y243 | 0 | phosphorylation | up-regulates activity | 0.258 | the polycomb group silencing protein Bmi1 can be phosphorylated by AKT, which enhances its oncogenic potential in PCa. Overexpression of Bmi1 can act in combination with PTEN haploinsufficiency to induce invasive carcinogenic formation in the prostate | SIGNOR-249583 |
Q9GZV5 | P06493 | 0 | phosphorylation | down-regulates activity | 0.258 | We found that TAZ is phosphorylated in vitro and in vivo by the mitotic kinase CDK1 at S90, S105, T326, and T346 during the G2/M phase of the cell cycle. Interestingly, mitotic phosphorylation inactivates TAZ oncogenic activity | SIGNOR-276518 |
P49841 | Q13237 | 0 | phosphorylation | down-regulates activity | 0.258 | These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII. | SIGNOR-280095 |
P10636-2 | P05771 | 0 | phosphorylation | down-regulates activity | 0.258 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275442 |
Q9UPG8 | Q8WUI4 | 0 | deacetylation | down-regulates | 0.258 | Plag1 and plagl2 are also regulated by acetylation. They are acetylated and activated by p300 and deacetylated and repressed by hdac7. | SIGNOR-140953 |
P46940 | P17252 | 0 | phosphorylation | up-regulates | 0.258 | Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. | SIGNOR-128714 |
O75874 | Q12778 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.258 | We identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. | SIGNOR-260101 |
P54646 | P12931 | 0 | phosphorylation | down-regulates activity | 0.258 | We show here that Src signaling leads to direct phosphorylation of the AMPK-α subunit on a novel site, tyrosine 179, resulting in suppression of AMPK-T172 phosphorylation and autophagy upon integrin-mediated cell adhesion. | SIGNOR-277573 |
P31645 | P12931 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.258 | We found that 1) SERT exists in a tyrosine-phosphorylated form, 2) inhibition of tyrosine kinase(s) reduces SERT expression levels by facilitating SERT protein degradation, 3) Src-kinase activity up-regulates SERT protein expression with a concomitant increase in 5-HT uptake and tyrosine phosphorylation, and 4) mutatio... | SIGNOR-276386 |
O00763 | Q96RU7 | 0 | binding | down-regulates quantity by destabilization | 0.258 | TRB3 appears to inhibit ACC activity by functioning as an adaptor for COP1. Taken together, these results suggest that TRB3 may promote loss of fat by mediating the COP1-dependent ubiquitination and inactivation of ACC. Taking these results together, we propose that TRB3 may protect against diet-induced obesity by st... | SIGNOR-271601 |
P51003 | P06493 | 0 | phosphorylation | up-regulates activity | 0.258 | Once an oocyte resumes meiosis, activated CDK1 and ERK1/2 cooperatively mediate the phosphorylation of three serine residues of PAPalpha, 537, 545 and 558, thereby leading to increased activity. | SIGNOR-268338 |
P13807 | Q9Y463 | 0 | phosphorylation | down-regulates activity | 0.258 | DYRK Family Protein Kinases Phosphorylate and Inactivate Glycogen Synthase. both protein kinases phosphorylate site 3a but no other sites that affect glycogen synthase activity. | SIGNOR-260633 |
P27986 | P01137 | 0 | binding | up-regulates activity | 0.258 | While association of the TGF_RI receptor with p85 requires TGF-_ stimulation. | SIGNOR-217960 |
Q6PGQ7 | P49841 | 0 | phosphorylation | up-regulates | 0.258 | It suggests that gsk3_ activity is required for hbora-mediated mitotic entry through ser274 and ser278 phosphorylation | SIGNOR-201519 |
Q9UQL6 | Q96GD4 | 0 | phosphorylation | down-regulates | 0.258 | We define the precise site of aurb-mediated phosphorylation as a conserved serine within the nuclear localization signals of hdac4, hdac5, and hdac9 at ser265, ser278, and ser242, respectivelyduring mitosis, aurb-mediated phosphorylation may localize class iia hdacs to a phosphorylation gradient at the spindle midzone,... | SIGNOR-198650 |
Q9UGL1 | P06493 | 0 | phosphorylation | down-regulates activity | 0.258 | Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer|Here, we demonstrate that KDM5B is phosphorylated at Ser1456 by the cyclin-dependent kinase 1 (CDK1). Phosphorylation of KDM5B at Ser1456 attenuated the occupancy of KDM5B on the promoters of pluripotency g... | SIGNOR-273435 |
P05067 | P11802 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.258 | These include a significant increase in APP phosphorylation at Thr 668 by cdk2, cdk4, and cdk5, which increases its beta-amyloid production and APP proteolysis by the activated caspases during cell cycle ( xref ; xref ; xref ; xref ). | SIGNOR-280214 |
P38936 | Q9Y463 | 0 | phosphorylation | up-regulates activity | 0.258 | Mirk exerts its anti-apoptotic effects during muscle differentiation at least in part through effects on the cell cycle inhibitor and pro-survival molecule p21cip1. Overexpression and rna interference experiments demonstrated that mirk phosphorylates p21 within its nuclear localization domain at ser-153 causing a porti... | SIGNOR-235635 |
O43623 | P0C2W1 | 0 | binding | down-regulates quantity by destabilization | 0.258 | One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbx... | SIGNOR-272182 |
Q12778 | Q96J02 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.258 | Mechanistically, Itch ubiquitinates Foxo1 for proteasomal degradation. | SIGNOR-278698 |
Q9UI33 | Q92915 | 0 | binding | down-regulates activity | 0.258 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253437 |
Q9Y2G1 | Q02750 | 0 | phosphorylation | down-regulates activity | 0.258 | Mek1 phosphorylation of Ndt80 therefore provides an elegant way for cells to know when it is safe to enter the first meiotic division.|These observations suggest that phosphorylation of the DBD by Mek1 prevents Ndt80 from binding to MSEs and explains how Mek1 phosphorylation can inhibit Ndt80 activity. | SIGNOR-279416 |
Q13233 | P00519 | 0 | phosphorylation | up-regulates activity | 0.258 | Moreover, c-Abl activates MEKK-1 in vitro and in response to DNA damage.|The results demonstrate that the nuclear c-Abl binds to MEKK-1 and that c-Abl phosphorylates MEKK-1 in vitro and in vivo. | SIGNOR-279672 |
Q9BQE3 | Q14980 | 0 | binding | up-regulates | 0.258 | Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. | SIGNOR-116677 |
Q14164 | P00533 | 0 | phosphorylation | up-regulates activity | 0.257 | To understand the mechanism by which IKBKE is activated by mutant EGFR, we first investigated if activating mutation of EGFR is able to form a complex with IKBKE.|While wild-type and mutant EGFR directly interacted with IKBKE, only mutant EGFR phosphorylated IKBKE on residues Y153 and Y179. | SIGNOR-278222 |
P40337 | Q96PY6 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.257 | Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization. Mutation of pVHL at S-168 increases protein stability. | SIGNOR-276434 |
Q9NP59 | Q16236 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.257 | NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification. SLC40A1 is a target gene of NFE2L2, with a putative ARE identified approximately -7 kb upstre... | SIGNOR-279863 |
Q9HAW8 | Q99626 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.257 | Using gel shift and functional assays, HNF1alpha was demonstrated to bind to and activate the UGT1A8, -1A9, and -1A10 promoters. In contrast, Cdx2 bound to and activated the UGT1A8 and -1A10 promoters but could not activate the UGT1A9 promoter. | SIGNOR-253968 |
Q01860 | Q9Y243 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.257 | Here we show that in ECCs, Akt phosphorylated the master pluripotency factor Oct4 at threonine 235, and that the levels of phosphorylated Oct4 in ECCs correlated with resistance to apoptosis and tumorigenic potential. Phosphorylation of Oct4 increased its stability and facilitated its nuclear localization and its inter... | SIGNOR-242107 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.