IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P54259 | P53779 | 0 | phosphorylation | down-regulates activity | 0.2 | Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-jun nh2-terminal kinase. serine 734 of the drpla protein is a phospho-acceptor site by jnk. The phosphorylation may be coupled to the activation of a protease. The molecular size of drpla protein detected in the rat brain with the specific phosphopepti... | SIGNOR-102394 |
O00555 | P43146 | 0 | null | up-regulates activity | 0.2 | DCC activation by a netrin-1 gradient creates a high-level [Ca2+]i gradient by triggering LCC activity and by stimulating the cAMP–PKA pathway, which further activates LCC in the plasma membrane (PM) and Ca2+ channels in the ER. | SIGNOR-268293 |
P49674 | Q86UY5 | 0 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273761 |
P10636 | P30153 | 0 | dephosphorylation | down-regulates | 0.2 | Galpha12 directly interacts with pp2a: evidence for galpha12-stimulated pp2a phosphatase activity and dephosphorylation of microtubule-associated protein, tau. | SIGNOR-130136 |
P42336 | Q13043 | 0 | phosphorylation | down-regulates activity | 0.2 | MST1/2 and HGK inhibit catalytic activity of p110α through phosphorylation at T1061 | SIGNOR-277920 |
Q27J81 | O43791 | 0 | binding | down-regulates activity | 0.2 | SPOP acts as an adaptor protein of the CUL3-RBX1 E3 ubiquitin ligase complex that generally recruits substrates for ubiquitination and subsequent degradation. Here, we revealed that SPOP recognizes a Ser/Thr (S/T)-rich motif in the C-terminal region of INF2 and triggers atypical polyubiquitination of INF2. These ubiqui... | SIGNOR-272798 |
O95163 | P42345 | 0 | phosphorylation | up-regulates activity | 0.2 | Human ELP1 S1174 phosphorylation was triggered by insulin treatment, as shown by the specific phosphorylated (p)ELP1 (S1174) antibody, and addition of a phosphorylation-mutant variant of the ELP1 protein (ELP1(S1174A)) to ELP1-depleted BRAFV600E melanoma cells failed to rescue cell survival |In line with these findings... | SIGNOR-275541 |
P16104 | Q99986 | 0 | phosphorylation | up-regulates activity | 0.2 | In response to DNA damage induced by ionizing radiation, histone H2AX is phosphorylated in Ser139 by VRK1. | SIGNOR-278370 |
Q03113 | O15552 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257342 |
P84243 | Q92831 | 0 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269620 |
Q9UPZ9 | Q8IZL9 | 0 | phosphorylation | up-regulates | 0.2 | Recombinant cak1p phosphorylates thr-157 in the tdy motif of recombinant ick and activates its activity in vitro. | SIGNOR-138420 |
P48023 | O43638 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | As we expected, Fkhl18 suppressed, dose-dependently,human and mouseFasLpromoter in bovine vascularsmooth muscle cells | SIGNOR-261612 |
O14548 | Q99683 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of EB1 by ASK1 promotes the binding of EB1 to CLIP-170 and p150 glued. | SIGNOR-278341 |
P55265 | P31751 | 0 | phosphorylation | down-regulates activity | 0.2 | AKT-dependent phosphorylation of the adenosine deaminases ADAR-1 and -2 inhibits deaminase activity. Coimmunoprecipitation studies and in vitro kinase assays revealed that AKT-1, -2, and -3 interact with both ADAR1p110 and ADAR2 and phosphorylate these RNA editases. Using site-directed mutagenesis of suspected AKT phos... | SIGNOR-276192 |
Q9H3R0 | P19525 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | In the absence of Wnt3a, protein kinase R phosphorylated KDM4C at Ser918, inducing KDM4C ubiquitination and degradation. | SIGNOR-277497 |
O00159 | P49841 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we report that at early G1 the glycogen synthase kinase 3\u03b2 phosphorylates and stabilizes Nuclear myosin 1c, allowing for Nuclear myosin 1c association with the chromatin. | SIGNOR-279184 |
Q01581 | P13674 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this study, we found that the prolyl 4-hydroxylase (P4H) subunit P4HA1 protects NPC cells from erastin-induced ferroptosis by activating HMGCS1, a key enzyme in the mevalonate pathway. Our results show that HMGCS1 and HMGCR are regulated by P4HA subunits at the transcriptional level (Fig. S4). | SIGNOR-279853 |
P42702 | Q92520 | 0 | binding | up-regulates activity | 0.2 | Interleukin-like EMT inducer (ILEI) a cytokine from the FAM3 family, also functions as a ligand for LIFR-gp130 heterodimer and mediates intracellular signal through STAT activation. | SIGNOR-277986 |
P15407 | Q04759 | 0 | phosphorylation | up-regulates activity | 0.2 | PKCθ-induced phosphorylations, in part at T217 and T227 residues, strongly and specifically increased Fra-1 transcriptional activity through the stimulation of Fra-1 transactivation domain, without affecting JUN factors. | SIGNOR-260879 |
Q04724 | Q96QT6 | 0 | binding | up-regulates activity | 0.2 | We have cloned and characterized a new member of the PHD zinc finger family called Pf1 that interacts with two global transcription corepressors: mSin3A and TLE. Pf1 interacts with TLE. The Groucho/TLE proteins are members of an abundant corepressor family, and we hypothesized that Pf1 might interact with TLE family m... | SIGNOR-266994 |
Q14457 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276561 |
Q14653 | P55286 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | CHD8 binds to histone H3 di- and trimethylated on lysine 4. It resides on the human U6 promoter as well as the mRNA IRF3 promoter in vivo and contributes to efficient transcription from both these promoters | SIGNOR-266898 |
Q04206 | P47710 | 0 | phosphorylation | up-regulates | 0.2 | Phosphorylation of serine 529 of p65 is mediated by casein kinase ii, but is prevented in nonstimulated cells by the interaction with ikba | SIGNOR-171222 |
Q07869 | P49840 | 0 | phosphorylation | up-regulates activity | 0.2 | GSK-3alpha phosphorylates PPARalpha at Ser280, located in the ligand binding domain.|These results suggest that GSK-3alpha positively regulates PPARalpha activity through Ser280 phosphorylation. | SIGNOR-278515 |
O60825 | P51812 | 0 | phosphorylation | up-regulates activity | 0.2 | Heart 6-phosphofructo-2-kinase activation by insulin results from ser-466 and ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase b. | SIGNOR-23753 |
Q14344 | P30411 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257399 |
P68431 | Q9C0A6 | 0 | methylation | up-regulates activity | 0.2 | SETD5 Exhibits Intrinsic Methyltransferase Activity on H3K36. This assay showed that SETD5 has specific histone methyltransferase activity toward K36 but not for other residues such as K4 and K27 (Figure 8B). we revealed that SETD5 is endowed with H3K36 methyltransferase, which is necessary for RNA elongation and proce... | SIGNOR-264620 |
P48729 | Q86UY5 | 0 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273748 |
Q8NET8 | P27361 | 0 | phosphorylation | up-regulates activity | 0.2 | We observed that ERK-mediated phosphorylation of TRPV3 alters its responsiveness to repeated chemical stimuli. Among several putative ERK phosphorylation sites, we identified threonine 264 in the N-terminal ankyrin repeat domain as the most critical site for the ERK-dependent modulation of TRPV3 channel activity. Of no... | SIGNOR-273672 |
P63096 | P55085 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256895 |
P49321 | P68400 | 0 | phosphorylation | down-regulates activity | 0.2 | Here, we show that somatic nuclear autoantigenic sperm protein (sNASP) binds to TRAF6 to prevent TRAF6 autoubiquitination in unstimulated macrophages. Following LPS stimulation, a complex consisting of sNASP, TRAF6, IRAK4, and casein kinase 2 (CK2) is formed. CK2 phosphorylates sNASP at serine 158, allowing sNASP to di... | SIGNOR-273627 |
O95863 | Q9UEW8 | 0 | phosphorylation | up-regulates activity | 0.2 | In this study, we found that STK39 also enhances SNAI1 stability by its phosphorylation at T203.|STK39 interacts with SNAI1 and phosphorylates SNAI1 on T203. | SIGNOR-279128 |
Q86VE9 | Q14004 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | In addition, CDK13-KD disrupted Nef downregulation of SERINC5 from the cell surface, whereas CDK12-KD did not (Figures 2D and 2E).|Thus, S360 phosphorylation increases interactions between Nef and SERINC5 and initiates the destruction of SERINC5 by the endocytic machinery.|Thus, we conclude that CycK/CDK13 phosphorylat... | SIGNOR-278918 |
P42224 | P23470 | 0 | dephosphorylation | up-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254727 |
Q9BYB0 | Q15398 | 0 | relocalization | up-regulates activity | 0.2 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264600 |
Q6ZMT4 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271572 |
P51684 | P78556 | 0 | binding | up-regulates activity | 0.2 | Liver and activation-regulated chemokine (LARC), also designated macrophage inflammatory protein-3alpha (MIP-3alpha), Exodus, or CCL20, is a C-C chemokine that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. LARC/MIP-3α is exerting its activity through binding to CCR6 (11, 12, 18, 19, ... | SIGNOR-278040 |
Q8TB45 | P35790 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | These data suggests that CKI overexpression may overcome a requirement for phosphorylation at the major mTOR sites in DEPTOR for formation of the degron and are consistent with our finding that CKI can phosphorylate S286 and S287 in DEPTOR in vitro in the absence of mTOR. | SIGNOR-279605 |
Q9UKX7 | P28482 | 0 | phosphorylation | down-regulates activity | 0.2 | Erk phosphorylates nup50 at ser221 and ser315 erk phosphorylation of the fg repeat region of nup50 reduced its affinity for importin-beta family proteins, importin-beta and transportin. | SIGNOR-188135 |
Q9H7P9 | P12931 | 0 | phosphorylation | up-regulates activity | 0.2 | Through deletion and base substitution mutagenesis we have identified Tyr489 of PLEKHG2 as the site phosphorylated by cSrc.The interaction between PLEKHG2 and the full-length of PIK3R3, but not ABL1, occurs in a tyrosine-phosphorylation-dependent manner. | SIGNOR-273808 |
Q9Y4P1 | Q9P289 | 0 | phosphorylation | up-regulates activity | 0.2 | ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4. MST4 phosphorylates ATG4B at serine residue 383, which stimulates ATG4B activity and increases autophagic flux. | SIGNOR-275833 |
P55268 | Q9NYD6 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | The specificity of binding of these two proteins to the Lamin B2 origin is confirmed by both band-shift and in vitro footprinting assays. In addition, the ability of HOXC10 and HOXC13 to increase the activity of a promoter containing the 74 bp sequence, as assayed by CAT-assay experiments, demonstrates a direct interac... | SIGNOR-261645 |
Q96RU2 | Q13535 | 0 | phosphorylation | up-regulates activity | 0.2 | Here we report that the deubiquitylase USP28 is recruited to sites of DNA damage in cisplatin-treated cells. ATR phosphorylates USP28 and increases its enzymatic activity.|Representative immunoblots of n = 3. C Immunoblotting of total and phosphorylated USP28 at serine 67 and 714 in A431 cells exposed to indicated conc... | SIGNOR-275850 |
Q5S007 | Q9UJV3 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. | SIGNOR-278763 |
P37840 | P25098 | 0 | phosphorylation | down-regulates activity | 0.2 | We found that grk-mediated phosphorylation inhibits synuclein's interaction with both phospholipids and pld2. These findings suggest that gpcrs may be able to indirectly stimulate pld2 activity via their ability to regulate grk-promoted phosphorylation of synuclein. | SIGNOR-78333 |
P32754 | Q96FA3 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. However, the regulation of HPD expression remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD... | SIGNOR-272959 |
Q6N021 | Q13131 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | We identify the tumour suppressor TET2 as a substrate of the AMP-activated kinase (AMPK), which phosphorylates TET2 at serine 99, thereby stabilizing the tumour suppressor. Increased glucose levels impede AMPK-mediated phosphorylation at serine 99, which results in the destabilization of TET2 followed by dysregulation ... | SIGNOR-256134 |
P50052 | P01019-PRO_0000032458 | 0 | binding | up-regulates activity | 0.2 | Ang II initiates most of the RAS-attributed physiologic effects through selective interactions with G-proteincoupled Ang II type 1 (AT1) or type 2 (AT2) receptors and subsequent activation of distinct intra cellular signaling pathways | SIGNOR-260237 |
P32243 | P14651 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Transactivation of the mouse OTX2 Luc constructs by the human HOXB1, HOXB2, and HOXB3 proteins. | Likewise, the construct pOTX2LucΔ−710 showed an 8-, 12-, and 6-fold increase in transcriptional activity if co-transfected with pSG-HOXB1, -HOXB2, and -HOXB3, respectively | SIGNOR-261635 |
P63244 | P05412 | 0 | null | up-regulates quantity by expression | 0.2 | In turn, c-Jun induces expression of RACK1, which is required for JNK activation by PKC, pointing to a c-Jun/RACK1/PKC/JNK feedback loop. | SIGNOR-278066 |
Q6DN03 | Q14493 | 0 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265382 |
O15527 | Q96PU5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | We demonstrate that recombinant NEDD4L stimulates ubiquitylation of OGG1 in vitro, particularly on lysine 341, and that NEDD4L and OGG1 interact in U2OS cells. | SIGNOR-278639 |
P63096 | P09619 | 0 | phosphorylation | up-regulates activity | 0.2 | RTKs directly phosphorylate Gαi on Y154, 155, and Y320. | SIGNOR-277232 |
P84243 | P51812 | 0 | phosphorylation | down-regulates activity | 0.2 | Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun. | SIGNOR-138471 |
Q15672 | P17252 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Because most of these sites were predicted to be phosphorylated by protein kinase C (PKC), we overexpressed PKCα in several cell lines and found that it phosphorylates Twist1 on Ser-144. we observed that PKCα-mediated Twist1 phosphorylation at Ser-144 inhibits Twist1 ubiquitination and consequently stabilizes it. | SIGNOR-277429 |
Q06830 | Q00534 | 0 | phosphorylation | down-regulates | 0.2 | Peroxiredoxin (prx) i is a member of the peroxiredoxin family of peroxidases and contains a consensus site (thr(90)-pro-lys-lys) for phosphorylation by cyclin-dependent kinases (cdks). This protein has now been shown to be phosphorylated specifically on thr(90) by several cdks, including cdc2, in vitro. Phosphorylation... | SIGNOR-87113 |
P01909 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271538 |
P42336 | Q8N4X5 | 0 | binding | up-regulates activity | 0.2 | RET/PTC induced robust tyrosine phosphorylation of XB130, which promoted its subsequent association with the p85alpha subunit of phosphatidylinositol 3-kinase (PI 3-kinase). We identified tyrosine 54 of XB130 as the major target of RET/PTC-mediated phosphorylation and a critical binding site for the SH2 domains of p85a... | SIGNOR-263193 |
Q96EP5 | P28482 | 0 | phosphorylation | down-regulates activity | 0.2 | Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growt... | SIGNOR-262970 |
Q9BT81 | Q9HCK8 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268922 |
Q14232 | P49841 | 0 | binding | down-regulates | 0.2 | Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). | SIGNOR-175436 |
Q92813 | P60604 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D... | SIGNOR-267484 |
Q969V6 | P27361 | 0 | phosphorylation | down-regulates | 0.2 | Serum induces rhoa-dependent translocation of mkl1 from the cytoplasm to the nucleus and also causes a rapid increase in mkl1 phosphorylation. Serum-induced phosphorylation of the serum response factor coactivator mkl1 by the extracellular signal-regulated kinase 1/2 pathway inhibits its nuclear localization. | SIGNOR-195157 |
Q8N752 | Q2M2I3 | 0 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273758 |
Q9ULK5 | P35790 | 0 | phosphorylation | down-regulates activity | 0.2 | CKI\u03b5-dependent phosphorylation increases Stbm turnover at junctions, and thus promotes complex sorting, while phosphorylation of Dsh decreases its turnover.|Interestingly, CKI\u03b5 has been implicated in phosphorylation of both Stbm and Dsh. | SIGNOR-278925 |
P08754 | P55085 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257028 |
P35568 | Q13627 | 0 | phosphorylation | up-regulates quantity | 0.2 | DYRK1A interacts with IRS-1 and phosphorylates IRS-1 at Ser-312 and Ser-616.|We found that DYRK1A overexpression up-regulated IRS-1 expression by slowing the turnover of IRS-1 protein. | SIGNOR-279521 |
O60234 | P00519 | 0 | phosphorylation | down-regulates activity | 0.2 | Acetylcholine stimulation also increased GMF-γ phosphorylation at Tyr-104. GMF-γ phosphorylation at this residue was mediated by c-Abl tyrosine kinase. The GMF-γ mutant Y104F (phenylalanine substitution at Tyr-104) had higher association with Arp2 in HASM cells upon contractile activation.Furthermore, expression of mut... | SIGNOR-273536 |
P17677 | Q6UB99 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Neurite growth-related genes such as Trkb, Bdnf, Gap43, Coronin 1B, and Rab13 are downregulated in ANKRD11-deficient neurons. | SIGNOR-266736 |
Q05639 | P59595 | 0 | binding | down-regulates activity | 0.2 | The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha | SIGNOR-260260 |
P30679 | Q13794 | 0 | phosphorylation | up-regulates activity | 0.2 | Ga16 is phosphorylated in vivo by PMA and by TRH receptor stimulation | SIGNOR-278131 |
P08237 | O75385 | 0 | phosphorylation | down-regulates activity | 0.2 | Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes including hexokinase (HK), phosphofructokinase 1 (PFK1), enolase 1 (ENO1), and the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP1).Phosphorylation of these enzymes leads to enhanc... | SIGNOR-274035 |
P61073 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.2 | Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. | SIGNOR-260898 |
Q00987 | Q8NEZ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | SCFFBXO22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis|we discovered Skp1-Cullin 1-FBXO22-ROC1 (SCFFBXO22) as the most dominating HDM2 E3 ubiquitin ligase from human proteome. The results of protein decay rate analysis, ubiquitination, siRNA-mediated silencing, and coimmunopreci... | SIGNOR-273440 |
Q9BY11 | Q9P286 | 0 | phosphorylation | up-regulates activity | 0.2 | We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1... | SIGNOR-263025 |
Q8NHL6 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271534 |
Q96CG3 | P31749 | 0 | phosphorylation | up-regulates activity | 0.2 | For the activation of signal 2, Akt is involved in TIFA Thr9 phosphorylation, which is essential for TIFA-TIFA homophilic oligomerization. Thr9 phosphorylation-dependent TIFA oligomerization facilitates the higher-order assembly of NLRP3 inflammasome, as indicated by the interaction between TIFA and caspase-1 in the ac... | SIGNOR-273542 |
Q92597 | P11309 | 0 | phosphorylation | down-regulates activity | 0.2 | Collectively, we find that PIM1 expression leads to increased levels of NDRG1 pS330, and PIM1 dependent NDRG1 phosphorylation decreases NDRG1 protein stability.|NDRG1 is phosphorylated by PIM1 at serine 330 (pS330), and the level of NDRG1 pS330 is associated higher grade prostate tumors. | SIGNOR-279308 |
Q16820 | P17252 | 0 | phosphorylation | down-regulates quantity | 0.2 | These findings suggest that activation of a protein kinase, presumably PKC, mediates PMA-induced hmeprinβ shedding. By labeling COS-1 cells transfected with mutant constructs lacking the potential phosphorylation sites, we identified Ser687 as the main 32P-acceptor. These data provide evidence that the cytoplasmic doma... | SIGNOR-263172 |
Q05682 | O75914 | 0 | phosphorylation | down-regulates | 0.2 | We investigated the effects of phosphorylation by p(21)-activated kinase 3 (pak) and calmodulin on the 22 kda c-terminal fragment of caldesmon (cad22). We substituted the major pak sites, ser-672 and ser-702, with either alanine or aspartic acid to mimic nonphosphorylated and constitutively phosphorylated states of cal... | SIGNOR-167976 |
Q9NSD9 | Q2TAL8 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269404 |
Q96DT5 | Q96M91 | 0 | binding | up-regulates activity | 0.2 | CFAP53 likely facilitates the transport of TTC25 and the dyneins into cilia. CFAP53 at the centriolar satellites may form a complex with TTC25 and ODAs, including DNAH5 and DNAH11, and regulate their trafficking into the cilium (Fig 10B). | SIGNOR-265545 |
P54793 | Q96SB4 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation by SRPK1 drives ASF from the cytosol to the nucleus.|Phosphorylation of ASF by SR protein kinase 1 (SRPK1) in the cytosol results in ASF relocation to the nucleus, whereas phosphorylation of ASF by Clk and Sty releases ASF from speckles and recruits it into nascent transcripts where ASF regulates altern... | SIGNOR-279765 |
Q8NBZ7 | P29320 | 0 | phosphorylation | up-regulates activity | 0.2 | However, it is possible that etk is a principal activator of Ugd.|The phosphorylation of the Ugd protein (a UDP-glucose dehydrogenase) by Etk increases Ugd dehydrogenase activity. | SIGNOR-280006 |
Q13530 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | The two serines within the PSAC of Serinc3 are phosphorylated by casein kinase II and mediate interaction with the μ subunits in vitro. | SIGNOR-273631 |
Q9BT88 | O60260 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Parkin binds to the C2A and C2B domains of synaptotagmin XI resulting in the polyubiquitination of synaptotagmin XI. Parkin-mediated ubiquitination also enhances the turnover of sytXI. | SIGNOR-272672 |
P38936 | Q15208 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | More importantly, with the direct regulation of p21 stability by phosphorylation on Ser 146, we define here the first downstream signaling mechanisms by which NDR kinases can control G1/S progression.|NDR kinases regulate p21 stability by phosphorylation of S146 on p21. | | SIGNOR-272961 |
P41212 | Q16549 | 0 | phosphorylation | down-regulates | 0.2 | In vivo p38-dependent phosphorylation reduced trans-repressional abilities of tel through ets-binding consensus site | SIGNOR-95622 |
Q8IVM8 | P20823 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Luciferase reporter gene constructs containing the OAT5 (SLC22A10) and OAT7 (SLC22A9) promoter regions were transactivated by HNF-1 in HepG2 cells. | SIGNOR-268982 |
O76090 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.2 | We have identified a PKC phosphorylation site (S358) located in the C terminal region of hBest1 critical for channel rundown. Phosphorylation of this site by PKC activators and PP2A inhibitors reduces channel rundown. | SIGNOR-260880 |
Q07954 | P01008 | 0 | binding | up-regulates | 0.2 | In vitro binding studies revealed that antithrombin iii (atiii)thrombin, heparin cofactor ii (hcii)thrombin, and ?1-antitrypsin (?1AT)trypsin bound to purified lrp. | SIGNOR-41232 |
Q9UIG0 | P27361 | 0 | phosphorylation | up-regulates | 0.2 | Wstf, a specific component of two chromatin remodeling complexes (swi/snf-type winac and iswi-type wich), was phosphorylated by the stimulation of mapk cascades in vitro and in vivo. Ser-158 residue in the wac (wstf/acf1/cbpq46) domain, located close to the n terminus of wstf, was identified as a major phosphorylation ... | SIGNOR-188164 |
Q16695 | Q96T68 | 0 | methylation | up-regulates activity | 0.2 | Here, we have characterized a previously undescribed member of the histone H3K9 methyltransferase family named CLLD8 (or SETDB2 or KMT1F). This protein contributes to the trimethylation of both interspersed repetitive elements and centromere-associated repeats and participates in the recruitment of heterochromatin prot... | SIGNOR-263895 |
P01106 | Q9BZ95 | 0 | binding | up-regulates quantity by stabilization | 0.2 | Indeed, dose-dependent TR-FRET and affinity pull-down assay confirmed the interaction of NSD3-s with MYC. Supporting functional significance of the interaction, co-expression of NSD3-s, but not the MYC-binding defective fragment of NSD3-s (1–347), stabilized MYC protein and increased MYC transcriptional activity as rev... | SIGNOR-259199 |
P07814 | Q00535 | 0 | phosphorylation | down-regulates | 0.2 | Ser(886) phosphorylation is required for the interaction of nsap1, which blocks eprs binding to target mrnas. The same phosphorylation event induces subsequent binding of ribosomal protein l13a and gapdh and restores mrna binding. Ifn-_ activates cdk5 to phosphorylate ser(886) in the linker domain of glutamyl-prolyl tr... | SIGNOR-187383 |
Q9NZW4 | Q9Y222 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In addition, our in vitro analyses showed that DMP1 and its 57-kDa C-terminal fragment significantly up-regulated the Dspp promoter activities in a mesenchymal cell line. | SIGNOR-271685 |
P41161 | Q14938 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles f... | SIGNOR-268886 |
P08833 | P17483 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | These data showed that Hox genes selectively activate the transcription of theIGFBP-1 | SIGNOR-261636 |
P63244 | Q5JWF2 | 0 | binding | down-regulates activity | 0.2 | The results showed that RACK1 severed as an oncogene to enhance the proliferation capacity of liver cancer cell lines, meanwhile, downregulated GNA14 expression in Huh7 cell lines reversed the effects of RACK1 on cell proliferation | SIGNOR-278048 |
P38936 | Q96J87 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | CELF6 binds to the 3'UTR of p21 transcript and increases its mRNA stability. Depletion of CELF6 promotes cell cycle progression, cell proliferation and colony formation whereas overexpression of CELF6 induces G1 phase arrest. | SIGNOR-269044 |
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