IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P19086 | P47900 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257273 |
Q63HR2 | P30530 | 0 | phosphorylation | up-regulates quantity | 0.2 | In this study, however, we demonstrate for the first time that Axl directly binds to and phosphorylates TNS2 at Y483.|Overall these results suggest that Axl positively regulates TNS2 expression. | SIGNOR-278471 |
Q03113 | O14843 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256957 |
P25025 | P25098 | 0 | phosphorylation | down-regulates activity | 0.2 | Upon activation, GRK2 phosphorylates CXCR2 and causes receptor desensitization and internalization, leading to down-regulation of neutrophil chemotaxis | SIGNOR-260647 |
Q9P219 | P54792 | 0 | binding | up-regulates | 0.2 | Daple binds to dvl and functions as a negative regulator of the wnt signalling pathway. | SIGNOR-199448 |
Q14653 | P03209 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | EBV Rta selectively down-regulates the expression of IRF3 and IRF7, the main regulators of the Type I IFNs. | SIGNOR-266644 |
Q14653 | P13288 | 0 | phosphorylation | down-regulates activity | 0.2 | BGLF4 kinase interacts physically with and phosphorylates IRF3, which is the initial activator of transcription in the innate immune response. BGLF4 suppresses IRF3-dependent transcriptional activation. Data here suggest that Ser123, Ser173, and Thr180 contribute additively to the BGLF4-mediated repression of the IRF3 ... | SIGNOR-266647 |
P16104 | O76064 | 0 | ubiquitination | up-regulates | 0.2 | Rnf8 can ubiquitylate histone h2a and h2ax, | SIGNOR-159309 |
Q9Y5H1 | Q9Y5I2 | 0 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265713 |
P10275 | Q9H3R0 | 0 | binding | up-regulates activity | 0.2 | JMJD2C was found to be co-localized with AR and LSD1 in the epithelium of prostate carcinoma and normal prostate cells. For the detailed mechanism, JMJD2C, AR and LSD1 assembled on the chromatin to remove the methyl groups from mono-, di- and trimethylated H3K9. Importantly, JMJD2C specifically removed the demethylatio... | SIGNOR-263879 |
Q9C0J9 | Q9Y618 | 0 | binding | up-regulates | 0.2 | The spen protein, sharp (smrt/hdac1-associated repressor protein), was identified as a component of transcriptional repression complexes in both nuclear receptor and notch/rbp-jkappa signaling pathways. | SIGNOR-104489 |
Q9Y5Y9 | Q92914 | 0 | binding | down-regulates activity | 0.2 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253442 |
Q7L9L4 | P54829 | 0 | dephosphorylation | up-regulates activity | 0.2 | PTPN5 dephosphorylates\nMob1a at Y26 residue. | SIGNOR-277058 |
P37231 | P36507 | 0 | binding | up-regulates | 0.2 | The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphoryl... | SIGNOR-179393 |
Q14653 | Q7TFA0 | 0 | binding | down-regulates activity | 0.2 | Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3.We also found that proteins 8b and 8ab could physically interact with IRF3. Overexpression of 8b and 8ab resulted ... | SIGNOR-260239 |
Q14653 | Q80H93 | 0 | binding | down-regulates activity | 0.2 | Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3.We also found that proteins 8b and 8ab could physically interact with IRF3. This counteracting effect was partiall... | SIGNOR-260240 |
Q12888 | P16403 | 0 | binding | down-regulates activity | 0.2 | Similarly, DNA-PK-mediated phosphorylation of H1.2 at T146 enhances p53 transcriptional activity by impeding H1.2 binding to p53 and thereby attenuating its suppressive effects on p53 transactivation. | SIGNOR-273833 |
P17812 | P17252 | 0 | phosphorylation | down-regulates | 0.2 | These data indicated that protein kinase c phosphorylation at ser(462) stimulates human ctp synthetase 1 activity, whereas phosphorylation at thr(455) inhibits activity. | SIGNOR-154621 |
P09086 | P07947 | 0 | phosphorylation | up-regulates activity | 0.2 | These data suggest that Yes1 is the TKI-sensitive kinase that can directly phosphorylate OCT2. | SIGNOR-279664 |
Q07812 | O60260 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | The E3 ligase parkin, which is known to trigger mitochondria specific autophagy, ubiquitylates BAX K128 and targets the pro apoptotic BCL-2 protein for proteasomal degradation. | SIGNOR-278529 |
Q8IWA4 | P05771 | 0 | phosphorylation | down-regulates activity | 0.2 | Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in partial loss of its GTPase activity and in a buildup of fragmented and dysfunctional mitochondria in heart failure. | SIGNOR-273826 |
Q96RT1 | O00192 | 0 | binding | up-regulates activity | 0.2 | We characterized the interactions between the Erbin PDZ domain and both ARVCF and δ-catenin in vitro and in vivo. endogenous δ-catenin and Erbin co-localized in and co-immunoprecipitated from neurons. These results suggest that δ-catenin and ARVCF may function to mediate the association of Erbin with the junctional cad... | SIGNOR-252119 |
P04083 | P24723 | 0 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202792 |
Q16778 | Q68DK7 | 0 | monoubiquitination | down-regulates activity | 0.2 | MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34u... | SIGNOR-271977 |
P45973 | Q5XPI4 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | In the present study, we report that HP1α and β undergo proteasomal degradation in lamin A/C knock-down cells and show by ectopic expression, RNAi and binding studies that the RING finger ubiquitin ligase RNF123 is directly involved in HP1 degradation. | SIGNOR-272035 |
O15350 | P17252 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we report that p73 is able to induce cell cycle arrest independently of its amino-terminal transactivation domain, whereas this domain is crucial for p73 proapoptotic functions. its activity is regulated throughout the cell cycle and modified by protein kinase C-dependent phosphorylation at serine residue 388. | SIGNOR-276235 |
Q13501 | Q14680 | 0 | phosphorylation | up-regulates activity | 0.2 | Consistent with our SILAC experiments, MELK directly phosphorylated SQSTM1 (XREF_FIG).|Furthermore, we show that MELK promotes melanoma growth by activating NF-kappaB pathway activity via Sequestosome 1 (SQSTM1 and p62). | SIGNOR-279544 |
P25098 | Q05655 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. In vitro, GRK2 was preferentially phosphorylated by PKC isoforms alpha, gamma, and delta. Two-dimensional peptide mapping of PKCalpha-phosphorylated GRK2 showed a single site of phosphorylation, which was identified as serine 29 by HPLC... | SIGNOR-249059 |
P07954 | P78527 | 0 | phosphorylation | up-regulates activity | 0.2 | We show that exposure to ionizing radiation induces DNA-PK-dependent phosphorylation of nuclear fumarase at Thr 236, which leads to an interaction between fumarase and the histone variant H2A.Z at DNA double-strand break (DSB) regions. | SIGNOR-266349 |
Q9NQG5 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.2 | Mechanistically, we revealed that CREPT/RPRD1B interacted with Aurora B to regulate the expression of Cyclin B1 in gastric cancer cells. Interestingly, Aurora B phosphorylates S145 in a well-conserved motif of CREPT/RPRD1B. We proposed that phosphorylation of CREPT/RPRD1B by Aurora B is required for promoting the trans... | SIGNOR-265499 |
O14649 | Q02156 | 0 | phosphorylation | down-regulates activity | 0.2 | We have previously shown that carbamylated PAF-induced repolarization abnormalities result from the protein kinase C (PKC) ε-dependent phosphorylation of the two-pore domain potassium channel TASK-1. Further studies identified threonine 383 in the C terminus of human and canine TASK-1 as the phosphorylation site requir... | SIGNOR-276431 |
Q03113 | P30411 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257344 |
Q92544 | Q16665 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Here, we investigated the impact of hypoxia on TM9SF4 expression in leukemic cells and identified TM9SF4 as a direct target of HIF-1α, downregulated in these cells by hypoxia. Then, we found that the hypoxia-mediated downregulation of TM9SF4 expression is associated with a decrease of cell adhesion of leukemic cells to... | SIGNOR-266705 |
Q14653 | P52292 | 0 | relocalization | up-regulates activity | 0.2 | The results from Figure 1C suggest that ORF6 inhibits IFN-β production through IRF3 or a component downstream of IRF3. Thus, we examined the effect of ORF6 on IRF3 nuclear translocation. Upon poly(I:C) treatment, IRF3 translocated to the cell nucleus in the absence of ORF6, whereas the expression of ORF6 blocked its nu... | SIGNOR-262514 |
Q8NEL9 | P68400 | 0 | phosphorylation | down-regulates activity | 0.2 | Here we incubated a recombinant preparation of the phospholipase in vitro with several enzymes including protein kinase CK2 (CK2), extracellular signal-regulated kinase 2 (ERK2), and protein phosphatase 2A (PP2A) to identify effects that might be of regulatory importance in vivo.Major findings were that 1) CK2 phosphor... | SIGNOR-262977 |
Q9BRK5 | Q8IXL6 | 0 | phosphorylation | up-regulates activity | 0.2 | Together, these results indicate that Fam20C kinase activity drives the sorting and secretion of the Cab45 dependent client LyzC.|We show that Fam20C phosphorylates Cab45 on distinct residues and thereby decreases Cab45 retention in the TGN. | SIGNOR-279330 |
Q9Y243 | P24666 | 0 | dephosphorylation | down-regulates activity | 0.2 | Reduction in the levels of both LMW-PTP isoforms in vitro and in vivo increased tyrosine phosphorylation of IR and AktSer473 and increased IRS-1- and IRS-2-associated PI3-K activities in both liver and fat.|Activated PI3-K stimulates Akt (or protein kinase B) that in turn phosphorylates and inactivates glycogen synthas... | SIGNOR-248457 |
Q9UK17 | P07948 | 0 | phosphorylation | up-regulates activity | 0.2 | These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. | SIGNOR-276395 |
P16104 | Q13315 | 0 | phosphorylation | up-regulates | 0.2 | H2ax interacts with numerous proteins required for dna damage signaling and repair when phosphorylated on ser-140. Phosphorylation of ser-140 (h2ax139ph) in response to ionizing radiation is mediated by both atm and prkdc. Our data showed that h2ax is phosphorylated by uva-activated jnk. | SIGNOR-160206 |
O60341 | Q9H3R0 | 0 | binding | up-regulates activity | 0.2 | JMJD2C was found to be co-localized with AR and LSD1 in the epithelium of prostate carcinoma and normal prostate cells. For the detailed mechanism, JMJD2C, AR and LSD1 assembled on the chromatin to remove the methyl groups from mono-, di- and trimethylated H3K9. Importantly, JMJD2C specifically removed the demethylatio... | SIGNOR-263880 |
P40763 | O60469 | 0 | binding | up-regulates activity | 0.2 | Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domai... | SIGNOR-264277 |
P15927 | Q96AP0 | 0 | binding | down-regulates activity | 0.2 | The current model for how telomeres repress ATR signaling proposes that POT1/TPP1 prevents the binding of RPA to the single-stranded telomeric DNA | SIGNOR-263327 |
O95243 | P04626 | 0 | phosphorylation | up-regulates activity | 0.2 | Importantly, we found that overexpression of HER2 alone is sufficient to induce MED1 phosphorylation at Thr (1032), a key site that is known to be critical for its functions, whereas blockage of HER2 or its downstream MAP kinase diminishes its phosphor ylation levels in these cells. | SIGNOR-279408 |
P01178-PRO_0000020495 | P16870 | 0 | cleavage | up-regulates activity | 0.2 | First, OT preprohormone is produced, that will be cleaved and matured by successive enzymes. The OT gene encodes for the Pre-Pro-OT-Neurophysin I (pre-pro-hormone), which is cleaved by different enzymes to give rise to different OT intermediate forms and to the Neurophysin I, and finally to the mature amidated form tha... | SIGNOR-270338 |
P25054 | O60729 | 0 | dephosphorylation | up-regulates | 0.2 | The phosphatase cdc14b translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase apc/ccdh1 | SIGNOR-179636 |
P55040 | P0DP24 | 0 | binding | up-regulates activity | 0.2 | Inhibition of voltage-gated calcium channels by Gem requires GTP and calmodulin binding, but not phosphorylation of serine 261 or 289. Calmodulin binding in the C-terminal extension of Gem is required for maximal inhibition of HVA Ca2+ channels by ectopically expressed Gem, as determined by measurement of electrical ac... | SIGNOR-266325 |
P63244 | P00519 | 0 | phosphorylation | up-regulates | 0.2 | Phosphorylation of rack1 on tyrosine 52 by c-abl is required for insulin-like growth factor i-mediated regulation of focal adhesion kinase.Tyrosine 52 is further shown to be phosphorylated by c-abl kinase, and the c-abl inhibitor sti571 disrupts fak interaction with rack1 | SIGNOR-185649 |
Q8TB45 | Q93009 | 0 | deubiquitination | up-regulates quantity by stabilization | 0.2 | Screening the DEPTOR interactome identified that the association of USP-7 deubiquitinase with DEPTOR was dependent upon S235 phosphorylation. Inhibition of USP-7 activity resulted in DEPTOR polyubiquitination and degradation. A scansite search suggested that ERK1 may be responsible for S235 phosphorylation, which was c... | SIGNOR-277588 |
P11413 | Q99558 | 0 | phosphorylation | up-regulates activity | 0.2 | Mass spectrometry identified four serine residues of G6PD phosphorylated by NIK (Extended Data Fig. 8f). All of these serines, except S278, are conserved between human and mouse G6PD proteins. In transfected cells, NIK stimulated G6PD activity, which was not affected by S8A or S486A mutation but abolished by S40A mutat... | SIGNOR-277545 |
Q9Y5G2 | Q9Y5I2 | 0 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265710 |
Q14896 | Q05655 | 0 | phosphorylation | up-regulates | 0.2 | The triple aspartic acid mutation shows greater distance between the two thick myosin filaments (affects the steric arrangement of the filament distances) in heart tissue. Mutation is cardioprotective during stress (ischemia-reprofusion injury) against apoptosis similar to isoproterenol treatment. | SIGNOR-150355 |
P30679 | P51582 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257214 |
Q9Y5H2 | Q9Y5I2 | 0 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265712 |
Q93077 | Q86Y13 | 0 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271759 |
P17542 | P17612 | 0 | phosphorylation | down-regulates | 0.2 | Thus, our data revealed a novel interplay between pka phosphorylation and tal1-mediated epigenetic regulation that regulates hematopoietic transcription and differentiation programs during hematopoiesis and leukemogenesis. | SIGNOR-195987 |
Q09472 | P12755 | 0 | binding | down-regulates | 0.2 | Smad2/3 interacts with c-ski through its c-terminal mh2 domain in a tgf-beta-dependent mannerc-ski is incorporated in the smad dna binding complex, interferes with the interaction of smad3 with a transcriptional co-activator, p300, and in turn recruits hdac. c-ski is thus a transcriptional co-repressor that links smads... | SIGNOR-72664 |
P00441 | Q9NX47 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation | SIGNOR-272982 |
P38936 | O60260 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Next, we defined whether pJNK is involved in parkin mediated p21 degradation.|Parkin ubiquitinates p21 in vivo and in vitro in an E3 ligase-substrate dependent manner. | SIGNOR-278640 |
P11279 | Q9NR19 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GU... | SIGNOR-276556 |
P42263 | Q5JU85 | 0 | relocalization | up-regulates quantity | 0.2 | BRAG1 increases the synaptic recycling pool of AMPARs.these data suggest that the BRAG1 enhancement of AMPAR transmission is mediated by the increased expression of the recycling pool of synaptic GluA2/3 receptors. | SIGNOR-264914 |
O43318 | Q01638 | 0 | binding | up-regulates activity | 0.2 | The activated heterodimer complex recruits downstream signaling components, including myeloid differentiation primary response protein 88 (MyD88), IL-1 receptor (IL-1R)–associated kinase, tumor necrosis factor (TNF) receptor–associated factor 6 (TRAF6), and transforming growth factor (TGF)-β–activated kinase 1 (TAK1) c... | SIGNOR-277716 |
Q16828 | P41162 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | ETV3 target genes including etv3, ddx20, and dusp6 provide negative feedback regulation of ETV3 production and activity. Negative feedback along with constitutive instability may serve to tightly regulate ETV3 abundance. Our date suggest that phosphorylation by ERK2 relieves repression by ETV3, allowing activation of c... | SIGNOR-262780 |
P51610 | Q8TAK5 | 0 | binding | down-regulates activity | 0.2 | The C1 factor interacts with the GABP_ transactivation domain.The domain of the C1 factor required for C1GABP interaction can inhibit GABP_dependent transcriptional activation | SIGNOR-221318 |
Q58F21 | P62805 | 0 | relocalization | up-regulates activity | 0.2 | BRDT interacts with acetylated nucleosomes via its BD1 domain. Binding may be initiated through non-specific interactions with DNA, which allow BRDT to localize to chromatin. Specificity is generated through recognition of tandem acetylated lysine residues (K5ac/K8ac) on the histone H4 tail, | SIGNOR-262066 |
P49327 | O15379 | 0 | deacetylation | up-regulates quantity by stabilization | 0.2 | Overexpression of HA-HDAC3 decreased the acetylation level of endogenous FASN by 35% in HEK293T cells, while the expression of a catalytic inactive mutant HDAC3Y298H (38) failed to reduce FASN acetylation (Fig. 4C). Conversely, HDAC3 knockdown increased the acetylation level of endogenous FASN by >1.5-fold in HEK293T c... | SIGNOR-267367 |
P30556 | P01019-PRO_0000032458 | 0 | binding | up-regulates activity | 0.2 | Ang II initiates most of the RAS-attributed physiologic effects through selective interactions with G-proteincoupled Ang II type 1 (AT1) or type 2 (AT2) receptors and subsequent activation of distinct intra cellular signaling pathways | SIGNOR-260238 |
Q9UI10 | P49841 | 0 | binding | down-regulates | 0.2 | Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). | SIGNOR-175572 |
Q8N3F0 | O15111 | 0 | phosphorylation | down-regulates activity | 0.2 | INKIT interacted with IKKα/β and TBK1/IKKɛ, impairing the recruitment and phosphorylation of p65 and IRF3. Viral infection induced IKK-mediated phosphorylation of INKIT at Ser58, resulting in its dissociation from the IKKs. Our findings thus uncover INKIT as a regulator of innate antiviral responses. | SIGNOR-273612 |
P49327 | Q9H7Z6 | 0 | acetylation | down-regulates quantity by destabilization | 0.2 | Overexpression of Myc-KAT8 increased the acetylation level of endogenous FASN by 2.2-fold (Fig. 3C). In contrast, knockdown of KAT8 decreased endogenous FASN acetylation by as much as 55% | SIGNOR-267366 |
P10636 | Q9UM73 | 0 | phosphorylation | up-regulates quantity | 0.2 | All these results point to the critical role played by ALK in the phosphorylation and accumulation of tau and in the associated memory impairment seen in 3xTg-AD mice. | SIGNOR-279318 |
Q13188 | P25098 | 0 | phosphorylation | up-regulates activity | 0.2 | Taken together, these studies support a role for GRK2 phosphorylation of Mst2 residues Ser-18 and Ser-316 in EGF-promoted centrosome separation.|Thus GRK2 appears to mediate EGF promoted cleavage and activation of Mst2. | SIGNOR-278206 |
Q13683 | P29692 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | alpha7 Integrin Expression Is Negatively Regulated by deltaEF1 during Skeletal Myogenesis | SIGNOR-241773 |
P35612 | P17252 | 0 | phosphorylation | down-regulates | 0.2 | We now demonstrate that ptn stimulates the phosphorylation of serines 713 and 726 in the myristoylated alanine-rich protein kinase (pk) c substrate domain of beta-adducin through activation of either pkc alpha or beta. | SIGNOR-139870 |
P46783 | O96006 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | HDRE-like sequences act as positive regulatory elements for RP gene promoter activities in vivo. | Cotransfection of a plasmid expressing hDREF increased luciferase expression directed by each RP gene promoter more than 30% compared with the values obtained without the hDREF-expressing plasmid. | SIGNOR-266083 |
P46527 | O15355 | 0 | dephosphorylation | up-regulates activity | 0.2 | By using genomic phosphatase screening, we identified a PPM family phosphatase, PPM1G, which could reduce p27 phosphorylation at T198.|Functionally, ectopic expression of PPM1G enhanced p27 protein stability and delayed cell cycle progression from G1 to S phase. | SIGNOR-277112 |
Q14974 | Q19QW5 | 0 | relocalization | down-regulates activity | 0.2 | ORF6 also retained KPNB1 at the ER/Golgi membrane in complex with KPNA2. Deletion of the N terminus of KPNA2, which binds KPNB1, no longer retained KPNB1 at the ER/Golgi membrane in the presence of ORF6 and did not antagonize STAT1 nuclear import in response to IFN-beta | SIGNOR-260275 |
P16104 | Q99502 | 0 | dephosphorylation | down-regulates | 0.2 | Tyr142 is dephosphorylated by the tyr phosphatases eya1 and eya3. | SIGNOR-168879 |
P41182 | Q9BZL6 | 0 | phosphorylation | down-regulates activity | 0.2 | Prkd2 directly binds to Bcl6 and Prkd2-dependent phosphorylation of Bcl6 is necessary to constrain Bcl6 to the cytoplasm, thereby limiting TFH development. | SIGNOR-279651 |
Q9BW19 | Q13315 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions.KIFC1 was stabilized upon phosphorylation and thus promoted centrosome clustering, CIN, and tumor recurrence both in vivo and in vitro. | SIGNOR-277295 |
Q96EV8 | Q86Y07 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | We show that VRK2 phosphorylates Ser 297 and Ser 299 of dysbindin using in vitro kinase assay. In addition, we found that VRK2-mediated phosphorylation of dysbindin enhanced ubiquitination of dysbindin and consequently resulted in the decrease in its protein stability through western blotting. | SIGNOR-277403 |
P29474 | P62140 | 0 | dephosphorylation | up-regulates activity | 0.2 | The increase in eNOS activity coincided with specific dephosphorylation of eNOS-Thr495, known to enhance eNOS activity. Inhibition of protein phosphatase 1 (PP1) by calyculin A, tautomycetin, or siRNA against PP1 reversed NF-induced eNOS-Thr495 dephosphorylation | SIGNOR-248574 |
O75581 | P17612 | 0 | phosphorylation | up-regulates activity | 0.2 | These results suggest that camppka activation is involved in activation of lrp6(...) our results demonstrate that lrp6 can be directly phosphorylated by pka catalytic subunit. | SIGNOR-181979 |
P08069 | P25098 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | GRK2 and GRK6 coimmunoprecipitate with IGF-1R and increase IGF-1R serine phosphorylation, promoting β-arrestin1 association. Using immunoprecipitation, confocal microscopy, and FRET analysis, we demonstrated β-arrestin/IGF-1R association to be transient for GRK2 and stable for GRK6. Using bioinformatic studies we ident... | SIGNOR-276413 |
P49585 | Q02086 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Sp3 is an activator, and Sp2 a repressor, of the Ctpct promoter in SL2 cells. | SIGNOR-266230 |
O95786 | Q8NG06 | 0 | ubiquitination | up-regulates activity | 0.2 | Specifically, the ubiquitin E3 ligase TRIM25 ubiquitinates K172 in the CARD2 of RIG-I, which is essential for the efficient interaction of RIG-I with MAVS and thereby for antiviral signal transduction | SIGNOR-264582 |
O43148 | Q9BTL3 | 0 | binding | up-regulates activity | 0.2 | Maturation and translation of mRNA in eukaryotes requires the addition of the 7-methylguanosine cap. In vertebrates, the cap methyltransferase, RNA guanine-7 methyltransferase (RNMT), has an activating subunit, RNMT-Activating Miniprotein (RAM). Here we report the first crystal structure of the human RNMT in complex wi... | SIGNOR-268344 |
O75534 | P35637 | 0 | post transcriptional regulation | up-regulates quantity by stabilization | 0.2 | These findings demonstrated that LINC00205 facilitates malignant phenotypes in LC by recruiting FUS to stabilize CSDE1, suggesting LINC00205 as a potential target for LC therapy.|Subsequent RIP assay con- firmed such prediction, as CSDE1 mRNA was evidently precipitated by anti-FUS (Figure 3A). | SIGNOR-262110 |
P38405 | O15552 | 0 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256946 |
O60318 | P24941 | 0 | phosphorylation | up-regulates activity | 0.2 | To study the inducible regulation of GANP DNA-primase during cell activation, we examined phosphorylation induced by various kinds of kinases.We observed that the cell cycle-associated kinase Cdks induced phosphorylation of GANP in vitro. Examination of immunoprecipitates of Cdk2 from B cells revealed phosphorylation o... | SIGNOR-262734 |
Q13148 | O14920 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation. Furthermore, we identified IKKβ-induced phosphorylation sites of TDP-43 and found that phosphorylation at Thr8 and Ser92 is important for the reduction of TDP-43 by IKK. | SIGNOR-277860 |
Q13586 | Q8IXL6 | 0 | phosphorylation | up-regulates activity | 0.2 | Similarly, STIM1 is phosphorylated on S88 by FAM20C both in vitro and in vivo. | SIGNOR-279173 |
P49959 | Q9H6R7 | 0 | binding | up-regulates activity | 0.2 | PLK1 Phosphorylates MMAP to Promote Its Interaction with KIF2A and MRE11. | SIGNOR-273733 |
P01116 | Q14156 | 0 | binding | up-regulates quantity | 0.2 | EFR3A directly binds to active KRAS through its C-terminus. EFR3A promotes the localization and nanoclustering of KRAS at the plasma membrane. | SIGNOR-269094 |
O43795 | P29323 | 0 | phosphorylation | up-regulates activity | 0.2 | EphB2 kinase activity is required for Myo1b-EphB2 interaction and induced Myo1b phosphorylation. | SIGNOR-279171 |
P40763 | Q8TD84 | 0 | binding | up-regulates activity | 0.2 | Our findings now further suggest that STAT3 and the adaptor protein SH2D2A interact with tyrosine‐containing motifs within the DSCAM/L1 ICDs. The SH2 domains of both STAT3 and SH2D2A are known to bind to phosphorylated tyrosine residues in the context of such motifs. Thus, the interactions between DSCAMs and SH2‐domai... | SIGNOR-264278 |
Q9UN70 | Q9Y5H9 | 0 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265674 |
P00441 | Q14689 | 0 | binding | up-regulates activity | 0.2 | DIP2a is associated with SOD in the mitochondria of mouse brain. DIP2a knockout inhibited SOD activity. In this paper, we analyzed the interacting proteins of DIP2A by mass spectrum analysis and found that DIP2A was correlated with superoxide dismutase (SOD), SOD1 and SOD2. Knockout of DIP2A decreased SOD activity and ... | SIGNOR-266591 |
Q9UK17 | P09769 | 0 | phosphorylation | up-regulates activity | 0.2 | These results indicate that Y108 (for Src-family kinases) and Y136 (for EGFR kinase) are involved in the tyrosine phosphorylation of hKv4.3 channels. | SIGNOR-276394 |
Q02962 | O75688 | 0 | dephosphorylation | down-regulates activity | 0.2 | PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation | SIGNOR-251712 |
Q9H0D6 | O76064 | 0 | ubiquitination | up-regulates activity | 0.2 | Mechanistically, RNF8 interacts with XRN2, which is crucial for transcription termination and R-loop resolution. We report that RNF8 ubiquitylates XRN2 to facilitate its recruitment to R-loop-prone genomic loci and that RNF8 deficiency in BRCA1-mutant breast cancer cells decreases XRN2 occupancy at R-loop-prone sites, ... | SIGNOR-277195 |
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