IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9HBW0 | P63096 | 1 | binding | up-regulates | 0.625 | Lysophosphatidic acid (lpa), a major g protein coupled receptor (gpcr)-activating ligand present in serum, elicits growth factor like responses by stimulating specific gpcrs coupled to heterotrimeric g proteins such as g(i), g(q), and g12/13. lpa2 also can couple to the gi/o, g12/13, and gqfamilies. | SIGNOR-84559 |
Q13873 | O00238 | 1 | binding | up-regulates | 0.625 | Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors (br-ia and br-ib) and the bmp type ii receptor (br-ii). | SIGNOR-75655 |
Q92696 | P20339 | 1 | lipidation | up-regulates activity | 0.625 | Prenylation (or geranylgeranylation) of Rab GTPases is catalysed by RGGT (Rab geranylgeranyl transferase) and requires REP (Rab escort protein). In the classical pathway, REP associates first with unprenylated Rab, which is then prenylated by RGGT. In the alternative pathway, REP associates first with RGGT; this compl... | SIGNOR-265572 |
Q16539 | P03372 | 1 | phosphorylation | up-regulates | 0.625 | Conversely, constitutively active mkk6 induced p38 mapk activation that recapitulated the effects of polyphenols by inducing eralpha phosphorylation and downstream activation of akt, and enos. The key role of eralpha ser-118 phosphorylation was confirmed in enos-transfected cos-7 cells | SIGNOR-136950 |
P78357 | Q12860 | 1 | relocalization | up-regulates activity | 0.625 | These results suggest that the targeting of contactin to different axonal domains may be determined, in part, via its association with Caspr. | SIGNOR-269073 |
Q9Y219 | P46531 | 1 | binding | up-regulates | 0.625 | Immunohistochemistry revealed coexpression of jagged2 and notch1 within thymus and other fetal murine tissues, consistent with interaction of the two proteins in vivo. Coculture of fibroblasts expressing human jagged2 with murine c2c12 myoblasts inhibited myogenic differentiation, accompanied by increased notch1 and th... | SIGNOR-236922 |
Q07820 | Q16611 | 1 | binding | down-regulates | 0.625 | Bax is held in check by mcl1, bcl-2, and either bcl2l1 or bcl2l2, or by all four. They bind a primed conformer of bak or bax | SIGNOR-149774 |
O95390 | Q13705 | 1 | binding | up-regulates | 0.625 | Here we demonstrate using genetic and biochemical studies that actriib and its subfamily receptor, actriia, cooperatively mediate the gdf11 signal in patterning the axial vertebrae, and that gdf11 binds to both actriia and actriib, and induces phosphorylation of smad2 | SIGNOR-95309 |
Q9H1J7 | O75581 | 1 | binding | up-regulates | 0.625 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131888 |
Q01484 | Q9UJW0 | 1 | relocalization | up-regulates quantity | 0.625 | We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4. | SIGNOR-266713 |
P22694 | P08138 | 1 | phosphorylation | up-regulates | 0.625 | Pka phosphorylates the p75 receptor and regulates its localization to lipid rafts. activation of camp?PKA Is required for translocation of p75ntr to lipid rafts, and for biochemical and biological activities of p75ntr, such as inactivation of rho and the neurite outgrowth. | SIGNOR-99755 |
Q93098 | Q9NPG1 | 1 | binding | up-regulates | 0.625 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-132024 |
Q92956 | O00463 | 1 | binding | up-regulates activity | 0.625 | ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5|synergistic activation of NF-κB by ATAR and TRAF5 293 cells | SIGNOR-262592 |
P07948 | Q9UN19 | 1 | phosphorylation | up-regulates activity | 0.625 | Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines|yrosine phosphorylation of DAPP-1 appears important for appropriate intracellular targeting and creates a potential ... | SIGNOR-249378 |
Q9UN37 | Q9Y3E7 | 1 | cleavage | up-regulates activity | 0.625 | Here, we show, using high-speed atomic force microscopy and electron microscopy, that the AAA-type adenosine triphosphatase VPS4 constricts and cleaves ESCRT-III CHMP2A-CHMP3 helical filaments in vitro. Our results demonstrate that VPS4 actively constricts ESCRT-III filaments and cleaves them before their complete disa... | SIGNOR-260847 |
Q9Y219 | Q9UM47 | 1 | binding | up-regulates | 0.625 | These results suggest that delta1, jagged1, and jagged2 are ligands for notch1 and notch3 receptors. | SIGNOR-82401 |
O14640 | P61586 | 1 | binding | up-regulates activity | 0.624 | Although there are other activators of PCP, Wnt5a can activate the PCP pathway by forming a complex with Fzd and Ror2 receptors, activating DVL, which in turn activates Rho-family small GTPases, including RhoA and Rac, and their downstream effectors, Rho-associated protein kinase (ROCK), the actin-binding protein, Fila... | SIGNOR-258971 |
P07949 | Q9P104 | 1 | binding | up-regulates | 0.624 | Dok-4 and dok-5 enhance c-ret-dependent activation of mitogen-activated protein kinase | SIGNOR-109516 |
P00747 | P25116 | 1 | cleavage | down-regulates activity | 0.624 | Plasmin mediates the lysis of fibrin clots and could in different studies activate platelets or inhibit the responses induced by thrombin (41-43). Our study favors a net inactivating effect on PAR1 despite minor cleavage at Arg41, on the basis of preferential cleavage at positions Arg70 and Lys76, COOH-terminal to the ... | SIGNOR-263572 |
P11802 | Q08050 | 1 | phosphorylation | up-regulates | 0.624 | We identified the forkhead box m1 (foxm1) transcription factor as a common critical phosphorylation target. Cdk4/6 stabilize and activate foxm1, thereby maintain expression of g1/s phase genes, suppress the levels of reactive oxygen species (ros), and protect cancer cells from senescence. | SIGNOR-177266 |
Q6PHR2 | P53990 | 1 | phosphorylation | down-regulates activity | 0.624 | ULK3 phosphorylation of IST1 is required to sustain the abscission checkpoint and inhibits IST1 function in abscission. | SIGNOR-278205 |
Q13464 | O14950 | 1 | phosphorylation | up-regulates | 0.624 | Here we found that rho-kinase has an activity for mrlc diphosphorylation at both threonine 18 and serine 19 in nonmuscle cells using sequential column chromatographies. | SIGNOR-91542 |
A2RUS2 | Q6IQ22 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.624 | ULK-mediated phosphorylation of the guanine nucleotide exchange factor DENND3 at serines 554 and 572 upregulates its GEF activity toward the small GTPase Rab12.|active Rab12 facilitates autophagosome trafficking, thus establishing a crucial role for the ULK/DENND3/Rab12 axis in starvation-induced autophagy. | SIGNOR-264734 |
Q5S007 | P37840 | 1 | phosphorylation | down-regulates activity | 0.624 | Here we show that full-length Lrrk2 or fragments containing its kinase domain have a significant capacity to phosphorylate recombinant alpha synuclein (Asyn) at serine 129. Such phosphorylated Asyn is the major component of pathological deposits in PD. | SIGNOR-249690 |
P12931 | Q14289 | 1 | phosphorylation | up-regulates | 0.624 | These data indicate that pyk2 activation via phosphorylation at tyr-402 requires ?V?3 Ligation and src activity. | SIGNOR-133870 |
P06493 | Q99459 | 1 | phosphorylation | up-regulates activity | 0.624 | Cdc5-dependent Net1 phosphorylation and Cdc14 release from the nucleolus require prior Cdc5 activation by Cdk1 and active separase to promote Cdc14 activation.|Cdk1 initially phosphorylates Cdc5, mostly at T242 and T238 (T242 phosphorylation is especially relevant based on our results), and phosphorylation activates it... | SIGNOR-279597 |
P24394 | O60674 | 1 | phosphorylation | up-regulates activity | 0.624 | Downstream intracellular signaling from the IL-4IL-4Rc complex involves activation of the Jak1 and Jak3 kinases, phosphorylation of the Stat6 transcription factor, and activation of the insulin receptor substrate (IRS)-2 and Dok2-signaling intermediates. IL-13 initially binds to IL-13R1 with intermediate affinity, and ... | SIGNOR-249530 |
P06401 | P03372 | 1 | binding | up-regulates | 0.624 | Here we identify two domains of prb, erid-i and -ii, mediating a direct interaction with the ligand-binding domain of eralpha. | SIGNOR-98807 |
P28482 | P04150 | 1 | phosphorylation | down-regulates activity | 0.623 | Cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK) phosphorylate the rat glucocorticoid receptor in vitro at distinct sites that together correspond to the major phosphorylated receptor residues observed in vivo; MAPK phosphorylates receptor residues threonine 171 and serine 246, whereas multiple... | SIGNOR-249428 |
Q13591 | Q9ULL4 | 1 | binding | up-regulates activity | 0.623 | Plexin-B3 is a functional receptor for semaphorin 5A. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). | SIGNOR-268373 |
Q9GZT5 | Q9NPG1 | 1 | binding | up-regulates | 0.623 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131616 |
P27361 | P84022 | 1 | phosphorylation | down-regulates | 0.623 | These results suggest that oncogenic ras, acting through mek1 and erk kinases, induces the phosphorylation of smad2 and smad3. | SIGNOR-66781 |
P25490 | P46531 | 1 | binding | down-regulates activity | 0.623 | Taken together, these results indicate that transcription factor YY1 may modulate Notch signaling via association with the high molecular weight Notch complex [..] both YY1 and N1IC were present in a large complex of the nucleus to suppress the luciferase reporter activity transactivated by Notch signaling. | SIGNOR-251654 |
P31751 | P49841 | 1 | phosphorylation | down-regulates activity | 0.623 | Active AKT, a common mediator of cell survival signals induced by radiation through multiple intracellular signaling pathways,11, 12 suppresses apoptosis. AKT positively regulates cyclin D1 expression through inactivation of glycogen synthase kinase 3_ (GSK3_). The AKT-mediated phosphorylation of glycogen synthase kina... | SIGNOR-245420 |
P13497 | P20908 | 1 | cleavage | up-regulates activity | 0.623 | BMP-1 Can Efficiently Cleave Pro-α1(V) N-propeptides and Pro-α2(V) C-propeptides and Less Efficiently Cleave Pro-α1(V) C-propeptides in Vitro.NH2-terminal sequencing of an ∼35-kDa band in the BMP-1-treated material (N-α1(V), Fig. 3 B,lanes 2 and 3) showed it to correspond to the NH2-terminal portion of the pro-α1(V) N-... | SIGNOR-256344 |
Q9NQ66 | P29992 | 2 | binding | up-regulates | 0.623 | Plc-_1 stimulates hydrolysis of gq/11-bound gtp and acts as a gtpase-activating protein (gap) for its physiologic regulator, gq/11 | SIGNOR-17239 |
Q13535 | Q9NVI1 | 1 | phosphorylation | up-regulates activity | 0.623 | Alternatively, the locally accumulated ATRIP-ATR might have sufficient activity to phosphorylate FANCI without TOPBP1 stimulation.|The results described above and our previous studies clearly indicated that FANCI phosphorylation is mediated by ATR kinase in a manner dependent on the FA core complex and FANCD2 protein. | SIGNOR-279320 |
O14905 | Q9NPG1 | 1 | binding | up-regulates | 0.623 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-132111 |
Q15052 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.623 | ARHGEF6 is a Rho guanine nucleotide exchange factor for Rac1 and constitutively bound to GIT1. NO and PGI2 activate PKG and PKA, respectively and both kinases phosphorylate ARHGEF6 on Ser-684 and possibly on Ser-640. Phosphorylation of ARHGEF6 results in the assembly of a GIT1-ARHGEF6–14-3-3 complex. These changes migh... | SIGNOR-272167 |
P49757 | P08151 | 1 | binding | down-regulates | 0.623 | The consequent activation of_ itch, together with the recruitment of gli1 through direct binding with_ numb, allows gli1 to enter into the complex, resulting in gli1 ubiquitination and degradation. | SIGNOR-167841 |
P35348 | Q14344 | 1 | binding | up-regulates activity | 0.623 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257279 |
Q13043 | O95835 | 1 | phosphorylation | up-regulates | 0.623 | We show that Mst2 and hWW45 interact with each other in human cells and that both Mst2 and Mst1 are able to phosphorylate Lats1 and Lats2, thereby stimulating Lats kinase activity. | SIGNOR-133551 |
Q9UBR4 | P61371 | 1 | binding | up-regulates activity | 0.623 | The Lhx3-Isl1 C terminus interaction was dependent on the LIM domains of Lhx3. The combinatorial expression of the LIM homeodomain proteins Isl1, Isl2, Lhx1, and Lhx3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets, imp... | SIGNOR-220169 |
P06239 | P27986 | 1 | phosphorylation | down-regulates activity | 0.623 | the regulatory p85 subunit of phosphatidylinositol 3-kinase is phosphorylated on tyrosine residues. We report that this phosphorylation event is readily catalyzed by the Abl and Lck protein-tyrosine kinases in vitro, by Bcr-Abl or a catalytically activated Lck-Y505F in co-transfected COS cells. we have mapped a major p... | SIGNOR-251383 |
O60674 | P04626 | 1 | phosphorylation | up-regulates activity | 0.623 | Our results indicate that autocrine secretion of PRL stimulates tyrosine phosphorylation of ErbB-2 by Jak2, provides docking sites for Grb2 and stimulates Ras-MAP kinase cascade, thereby causing unrestricted cellular proliferation. | SIGNOR-279197 |
P29992 | Q9NQ66 | 2 | binding | up-regulates activity | 0.623 | TRH-R1 receptor, which is coupled to Gq/11 protein, activates phospholipase C, mobilizes calcium and activates protein kinase C. | SIGNOR-267203 |
P29350 | P21854 | 1 | dephosphorylation | down-regulates | 0.623 | Our work clearly identifies cd72 as both an shp-1 binding protein (figure 1,figure 2) and a direct substrate for shp-1 in vivo (figure 3). As tyrosine phosphorylation of cd72 strongly correlates with the ability of the bcr to deliver growth-inhibitory/apoptosis-inducing signals (figure 4), our results suggest that shp-... | SIGNOR-60155 |
Q05923 | Q16539 | 1 | dephosphorylation | down-regulates | 0.623 | We show that the in vivo substrate specificities of individual phosphatases are unique. Pac1, mkp-2, and mkp-1 recognize erk and p38, erk and jnk, and erk, p38, and jnk, respectively | SIGNOR-40918 |
P67775 | P28749 | 1 | dephosphorylation | up-regulates | 0.623 | Pocket protein family consists of the retinoblastoma tumor suppressor protein (prb) and the functionally and structurally related proteins p107 and p130./dephosphorylation of p130 and p107 in cell extracts is inhibited by concentrations of okadaic acid known to inhibit pp2a, but not pp1. Finally, the pp2a catalytic sub... | SIGNOR-129749 |
Q16633 | P14859 | 1 | binding | up-regulates | 0.622 | Obf1 enhances transcriptional potential of oct1. | SIGNOR-100968 |
P35813 | P84022 | 1 | dephosphorylation | down-regulates activity | 0.622 | Ppm1a dephosphorylates and promotes nuclear export of tgfbeta-activated smad2/3; these results suggest that phospho-smad2 is a direct substrate of mg2+-dependent ppm1a. in conclusion, ppm1a is a bona fide phosphatase that directly dephosphorylates the critical sxs motif of r-smads. | SIGNOR-232110 |
Q16539 | O95644 | 1 | phosphorylation | down-regulates | 0.622 | We show that jnk, erk, and p38 physically associate with the nfatc n-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating nfatc subcellular localization, namely ser(172) and the conserved nfatc ser-pro repeats. | SIGNOR-74560 |
P50750 | P84022 | 1 | phosphorylation | down-regulates activity | 0.622 | Similarly, tgf-?-Induced and cdk8/9-mediated phosphorylation of smad3 at threonine 179 (t179) is important for binding of the nedd4l e3 ubiquitin ligase, which accelerates smad3 turnover;cdk8 and cyclint-cdk9 showed a preference for s206 and s214 but also phosphorylated s186 and s195 in the case of smad1;and t179, s208... | SIGNOR-161589 |
Q00535 | Q14194 | 1 | phosphorylation | up-regulates | 0.622 | These findings suggest that sema3a-induced spine development is regulated by phosphorylation of crmp1 by cdk5. Introduction of crmp1-wt, but not crmp1-t509a/s522a, a crmp1 mutant that cannot be phosphorylated by cdk5, rescued the defect in sema3a responsiveness. | SIGNOR-159314 |
Q9BWP8 | P48740 | 1 | binding | up-regulates activity | 0.622 | On the basis of the significant concentration of CL-11 in circulation and CL-11's interaction with various microorganisms and MASP-1 and/or MASP-3, it is conceivable that CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms. | SIGNOR-263409 |
P17706 | P06213 | 1 | dephosphorylation | down-regulates | 0.622 | Finally, we have tested the set of ptps for their ability to dephosphorylate a phosphopeptide corresponding to the irk autophosphorylation site. tc-ptp, sap-1, and ptp-1b all tested positive, but ptp-? Showed no activity, although the same gst-ptp preparation could efficiently convert pnpp (tablei). Interestingly, many... | SIGNOR-75914 |
P53350 | O75122 | 1 | phosphorylation | up-regulates activity | 0.622 | Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.|Finally, we demonstrate that CLASP2 phosphorylation on S1234 and S1255 by Cdk1 and Plk1, respectively, increases with conditions that allow the establishment and stabilization of KT\u2013MT attachments ( xref ). | SIGNOR-278321 |
P31749 | P84022 | 1 | binding | down-regulates | 0.622 | Pkb inhibits smad3 by preventing its phosphorylation, binding to smad4 and nuclear translocation. [...] Regulation of smad3 by pkb occurs through a kinase-activity-independent mechanism, resulting in a decrease in smad3-mediated transcription and protection of cells against tgf-beta-induced apoptosis. | SIGNOR-123606 |
P02545 | Q9UH99 | 1 | relocalization | up-regulates activity | 0.622 | In the case of Sun2, there is some evidence that A-type lamins might contribute to Sun2 localization in the INM. We report that an interaction between subunits of the HOPS complex and the ERM (ezrin, radixin, moesin) proteins is required for the delivery of EGF receptor (EGFR) to lysosomes. Inhibiting either ERM protei... | SIGNOR-261310 |
Q13882 | P40763 | 1 | phosphorylation | up-regulates activity | 0.622 | 29 PTK6 promotes activating phosphorylation of STAT3 at tyrosine residue 705.|STAT3 has been shown to promote tumor initiation of different tumor types, including those of the gastrointestinal tract and skin, and PTK6 was previously shown to promote STAT3 activation and tumorigenesis in mouse models of colon and skin c... | SIGNOR-278346 |
Q86VW2 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates | 0.622 | Exogenous expression of geft promotes myogenesis ofc2c12 cells via activation of rhoa, rac1, and cdc42 and their downstream effector proteins, while a dominant negative mutant of geft inhibits this process. | SIGNOR-236882 |
Q12972 | P62136 | 1 | binding | down-regulates activity | 0.622 | We have purified two of these nuclear inhibitors of PP-1 (NIPP-1a and NIPP-1b) until homogeneity. | SIGNOR-255657 |
P40763 | P14210 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.622 | Coexpression of activated c-Src and Stat3 synergistically induced strong HGF promoter activity in SP1 cells | SIGNOR-251742 |
O14904 | Q9NPG1 | 1 | binding | up-regulates | 0.622 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-132070 |
Q15831 | P43268 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.622 | LKB1 phosphorylated PEA3 and promoted its degradation through a proteasome-mediated mechanism. | SIGNOR-279293 |
Q06124 | P21802 | 1 | dephosphorylation | down-regulates activity | 0.622 | In forming this heterotetrameric complex Grb2 inhibits both the dephosphorylation of FGFR2 by Shp2 and the phosphorylation of Shp2 by FGFR2 (XREF_FIG, respectively).|Knockdown of Grb2 elevates Shp2 phosphorylation (XREF_FIG), strongly suggesting that the inability of Shp2 to interact directly with the receptor in the p... | SIGNOR-277030 |
Q2M1P5 | P08151 | 1 | binding | up-regulates quantity by stabilization | 0.622 | Kif7 physically interacted with Gli transcription factors and controlled their proteolysis and stability, and acted both positively and negatively in Hh signaling. | SIGNOR-209608 |
P67775 | P28482 | 1 | dephosphorylation | down-regulates activity | 0.621 | P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3).Mapk activity is tightly regulated by phosphorylation and dephosphorylation. The activation of the mapk activity requires the dual phosphorylation of the ser/thr and tyr residues in the t... | SIGNOR-103159 |
O60346 | P31751 | 1 | dephosphorylation | down-regulates activity | 0.621 | The Abl kinase inhibitors and depletion of Bcr-Abl induced the expression of PHLPP1 and PHLPP2, which dephosphorylated Ser-473 on Akt1, -2, and -3, resulting in inhibited proliferation of CML cells.|Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylati... | SIGNOR-248328 |
Q00987 | Q92831 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.621 | Consistently, overexpression of MDM2 in p53 null cells caused the reduction of the protein level of PCAF, but not the mRNA level.|MDM2 ubiquitinated PCAF in vitro and in cells. | SIGNOR-278825 |
O14492 | P06213 | 1 | binding | down-regulates | 0.621 | APS couples c-Cbl to the insulin receptor, resulting in ubiquitination of the insulin receptor. | SIGNOR-109694 |
Q53G59 | O14640 | 1 | binding | down-regulates quantity by destabilization | 0.621 | KLHL12 recruits Dsh to Cullin-3 for protein degradation. In vitro ubiquitination of Dsh3 by KLHL12–Cullin-3–Roc1. The E3 ligase complex was obtained by transfection of HEK293T cells . We show that the BTB-containing protein KLHL12 negatively regulates Dsh function by recruiting a pool of Dsh to the Cullin-3 ligase sc... | SIGNOR-271558 |
Q16539 | P40763 | 1 | phosphorylation | up-regulates | 0.621 | All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: ... | SIGNOR-154783 |
P45983 | O95644 | 1 | phosphorylation | down-regulates activity | 0.621 | It has been previously shown that NF-ATc1 accumulates in the nucleus of activated CD4 + T cells from Jnk1 \n \u2212/\u2212 mice 35\u2022 and that JNK1 phosphorylates and inactivates NFATc1 in Jurkat T cells 47 , indicating that JNK1 is an inhibitor of NFAT. | SIGNOR-280031 |
P13945 | P63092 | 1 | binding | up-regulates activity | 0.621 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256753 |
O14640 | P49841 | 1 | binding | down-regulates activity | 0.621 | In canonical wnt signaling, dsh phosphorylation inhibits the apcaxingsk3 complex, leading to beta-catenin stabilization. | SIGNOR-167957 |
Q96EB6 | O75376 | 1 | null | up-regulates | 0.621 | In differentiated adipocyte cell lines, SIRT1 inhibits adipogenesis and enhances fat mobilization through lipolysis by suppressing the activity of PPARγ. SIRT1 achieves this by promoting the assembly of a corepressor complex, involving NCoR1 and SMRT, on the promoters of PPARγ target genes to repress their transcriptio... | SIGNOR-253505 |
Q96EB6 | P15172 | 1 | null | down-regulates activity | 0.621 | Sir2 forms a complex with the acetyltransferase PCAF and MyoD and, when overexpressed, retards muscle differentiation | SIGNOR-241963 |
Q9H1J5 | Q9NPG1 | 1 | binding | up-regulates | 0.621 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131984 |
Q6PHR2 | P10070 | 1 | phosphorylation | up-regulates activity | 0.621 | We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro | SIGNOR-260798 |
O75582 | P05114 | 1 | phosphorylation | down-regulates activity | 0.62 | HMGN1 (formerly known as HMG-14) phosphorylation at Ser6 occurs concomitantly with IE gene expression. | MSK2 seems to be the most important kinase responsible for this modification |Accordingly, it was suggested that HMGN1 phosphorylation reduces binding of the protein to the nucleosomes | SIGNOR-262988 |
P51878 | P57764 | 1 | cleavage | up-regulates activity | 0.62 | Co-expression of GSDMD with caspase-1, 4, 5 or 11 but not apoptotic caspases (caspase-2, 8 and 9) in 293T cells induced the same cleavage of GSDMD|inflammatory caspases specifically cleave GSDMD after the 272FLTD275 (or 273LLSD276) sequence | | SIGNOR-256418 |
Q9NPE3 | O14746 | 1 | binding | up-regulates activity | 0.62 | Dyskerin was recently found to be associated with active human telomerase (34), and mutations in dyskerin or NOP10 or deletion of the H/ACA motif of hTERC result in diminished telomerase activity | SIGNOR-263331 |
P60484 | Q70Z35 | 2 | binding | down-regulates activity | 0.62 | Here, we used cell biology, biochemistry, and genetic approaches to show that PTEN suppresses cell movement by blocking PREX2 GEF–catalyzed activation of the GTPase RAC1. PTEN binds PREX2 and directly inhibits GEF activity. | SIGNOR-259190 |
P15976 | P17947 | 2 | binding | down-regulates activity | 0.62 | GATA-1 represses PU.1 activity.We have in this report found that the GATA-1 transcription factor is capable of functionally interfering with the PU.1 protein and have provided evidence that this interference is mediated through interaction between the PU.1 ETS domain and the GATA-1 C-finger region. | SIGNOR-256050 |
Q16566 | P56524 | 1 | phosphorylation | down-regulates activity | 0.62 | CaMKIV phosphorylates HDAC4 in vitro and promotes its nuclear-cytoplasmic shuttling in vivo. | Thus, CaMKIV can phosphorylate HDAC4 at Ser-467 and/or Ser-632 in vitro. | Collectively, our results suggest that CaMKIV reverses the transcriptional repression activity of HDAC4 by stimulating the mobilization of HDAC4 out o... | SIGNOR-250712 |
P02649 | Q92673 | 1 | binding | up-regulates | 0.62 | Lr11 binds the apolipoprotein e (apoe)-rich lipoproteins, beta-very low density lipoproteins (vldls), with a high affinity similar to that of other members, such as the ldlr and vldl receptor.Incubation For 48 hours with beta-vldl of lr11-overexpressing cells, but not of control cells, promotes the appearance of numero... | SIGNOR-110555 |
Q70Z35 | P60484 | 2 | binding | down-regulates activity | 0.62 | Here, we report that P-REX2 interacts with PTEN via two interfaces. In summary, P-REX2 docks to the PDZ-BD of PTEN through its C-terminal domain, reads the phosphorylation state of the PTEN tail via the DH domain, and inhibits PTEN activity by unleashing the PH domain | SIGNOR-259189 |
P68400 | Q13547 | 1 | phosphorylation | up-regulates | 0.62 | Human hdac1 protein was analyzed by ion trap mass spectrometry, and two phosphorylated serine residues, ser(421) and ser(423), were unambiguously identified. Loss of phosphorylation at ser(421) and ser(423) due to mutation to alanine or disruption of the casein kinase 2 consensus sequence directing phosphorylation redu... | SIGNOR-111015 |
P49137 | Q07352 | 1 | phosphorylation | down-regulates | 0.62 | Mk2-mediated inhibition of brf1 requires phosphorylation at s54, s92, and s203. Phosphorylation of brf1 by mk2 does not appear to alter its ability to interact with ares or to associate with mrna decay enzymes. Thus, mk2 inhibits brf1-dependent amd through direct phosphorylation. | SIGNOR-161274 |
P31269 | O00470 | 1 | binding | up-regulates activity | 0.62 | We now show that the Hoxa-9 protein physically interacts with Meis1 proteins. Hox proteins from the other AbdB-like paralogs, Hoxa-10, Hoxa-11, Hoxd-12, and Hoxb-13, also form DNA binding complexes with Meis1b. DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with ... | SIGNOR-241162 |
Q16661 | P25092 | 1 | binding | up-regulates | 0.62 | Guanylins activate two receptors, gc-c and ok-gc, which are expressed in intestine and/or kidney. | SIGNOR-78120 |
Q9Y6E7 | P00367 | 1 | glycosylation | down-regulates activity | 0.62 | We show that SIRT4 is a mitochondrial enzyme that uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH) activity. | SIGNOR-267828 |
Q8N5S9 | Q16566 | 1 | phosphorylation | up-regulates | 0.62 | Phosphorylation of ca(2+)/cam-bound camkiv on its activation loop threonine (residue thr(200) in human camkiv) by ca(2+)/calmodulin-dependent kinase kinase leads to increased camkiv kinase activity. | SIGNOR-134649 |
Q13188 | O95835 | 1 | phosphorylation | up-regulates | 0.62 | Since the N-terminal half of Lats1 (residues 1588) was dispensable for the activation of Lats1 by Mst2, mass spectrometry was used to identify phosphorylation sites within the C-terminal domain of Lats1. | SIGNOR-132927 |
Q96RR4 | Q16566 | 1 | phosphorylation | up-regulates activity | 0.62 | Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. | SIGNOR-250718 |
P07948 | P16885 | 1 | phosphorylation | up-regulates activity | 0.62 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-249384 |
O14920 | Q04864 | 1 | phosphorylation | up-regulates activity | 0.62 | We are the first to identify Ser484 and Ser494 as the major sites of in vitro phosphorylation of REL by IKKalpha and IKKbeta. | SIGNOR-279620 |
P18146 | P37231 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.62 | Previous studies have reported that the PPARγ proximal promoter contains an overlapping binding site for Egr-1, which is involved in the down-regulation of PPARγ. In the present study, we have provided direct evidence that leptin causes PPARγ reduction in primary cultured PASMC; this effect is coupled to leptin-induced... | SIGNOR-263508 |
P17947 | P15976 | 2 | binding | down-regulates activity | 0.62 | We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. PU.1 represses GATA-1-mediated transcriptional activation. | SIGNOR-256049 |
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