IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q07912 | P10275 | 1 | phosphorylation | up-regulates activity | 0.545 | Ack1 interacted with and phosphorylated AR protein at Tyr 267 and Ack1 was shown to be required for optimal AR target gene expression and AR recruitment.|Two intracellular tyrosine kinases, Ack1 (activated cdc42 associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growt... | SIGNOR-278194 |
P07948 | Q06187 | 1 | phosphorylation | up-regulates | 0.545 | Phosphorylation at y551 requires lyn kinase activity, indicating that y551 is a transphosphorylation site \ this transphosphorylation at y551 is followed by phosphorylation at a second site, which is dependent on btk catalytic activity. | SIGNOR-41607 |
P68400 | Q6VY07 | 1 | phosphorylation | up-regulates activity | 0.545 | Phosphorylation of Ser278 by CK2 or a Ser278-->Asp mutation increased the interaction between PACS-1 and cargo, whereas a Ser278-->Ala substitution decreased this interaction. Moreover, the Ser278-->Ala mutation yields a dominant-negative PACS-1 molecule that selectively blocks retrieval of PACS-1-regulated cargo molec... | SIGNOR-250925 |
Q07812 | Q9NR28 | 1 | relocalization | up-regulates | 0.545 | Bax and/or bak-mediated release of pro-apoptotic mediators including smac/diablo and omi | SIGNOR-87109 |
Q96SN8 | O43379 | 1 | relocalization | up-regulates activity | 0.545 | Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at seq... | SIGNOR-271723 |
Q6W2J9 | Q99496 | 1 | binding | up-regulates activity | 0.545 | BcoR and Fbxl10/Jhdm1B are among the most abundant Ring1B/Rnf2 interactors identified with the highest confidence, and their association has been validated by coimmunoprecipitation studies; hence we call this the Fbxl10-BcoR complex. In summary, we have widened the set of multiprotein complexes containing the Polycomb... | SIGNOR-252241 |
O95628 | P41229 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.545 | In our study, we show that the protein level of the yeast histone H3 Lys 4 (H3 K4) demethylase Jhd2/Kdm5 is modulated through polyubiquitination by the E3 ubiquitin ligase Not4 and turnover by the proteasome. Finally, we show that human NOT4 can polyubiquitinate human JARID1C/SMCX, a homolog of Jhd2, suggesting that ... | SIGNOR-271468 |
P23471 | Q9UM73 | 1 | dephosphorylation | down-regulates | 0.545 | Rptpbeta/zeta dephosphorylates alk at the site(s) in alk that is undergoing autophosphorylation through autoactivation. | SIGNOR-157227 |
Q96N67 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.545 | As a GEF, Dock7 exchanges GDP for GTP on Cdc42 and Rac1, causing their activation, followed by activation of downstream effectors, including the dephosphorylation (activation) of cofilin, a key regulator of actin turnover. | SIGNOR-261887 |
Q9Y5Z0 | P05067 | 1 | cleavage | up-regulates activity | 0.544 | BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.|Figure 6 Preferred BACE1 and BACE2 cleavage sites. (A) Sequence of APP indicating α- and β-cleavage sites, BACE1- and BACE2-cleavage sites, and the location of mutations analyzed here. ... | SIGNOR-261773 |
O15111 | Q9NQC7 | 1 | phosphorylation | up-regulates activity | 0.544 | The phosphorylation of cyld was completely abolished by the combined mutations of the entire serine cluster (m4, lane 5). Similar results were obtained with the ikk holoenzyme (fig. 4c, panel 1), recombinant ikk_ (panel 2), and recombinant ikk_cyld phosphorylation may serve as a mechanism to inactivate its traf2 deubiq... | SIGNOR-204692 |
Q86XK2 | Q9NZJ0 | 1 | binding | down-regulates | 0.544 | We determined that the f-box protein fbxo11 interacts with cdt2,a dcaf protein that controls cell-cycle progression, and recruits cdt2 to the scf(fbxo11)complex to promote its proteasomal degradation. | SIGNOR-192325 |
Q9Y297 | P46937 | 1 | ubiquitination | down-regulates | 0.544 | This cascade of phosphorylation allows the binding of scfbetatrcp that promotes the ubiquitination and degradation of yap. | SIGNOR-201138 |
P01106 | P25490 | 2 | binding | down-regulates activity | 0.544 | Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfec... | SIGNOR-268795 |
Q05209 | Q14289 | 1 | dephosphorylation | down-regulates activity | 0.544 | Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-pest-mediated dephosphorylation. / dephosphorylation of tyr402 and tyr579/580 by ptp-pest | SIGNOR-107502 |
Q13131 | Q53ET0 | 1 | phosphorylation | down-regulates | 0.544 | Collectively, these findings suggest ampk suppresses glucose production through two transcriptional effects:reduced expression of creb targets via crtc inactivation and reduced expression of foxo target genes via class iia hdac inactivation | SIGNOR-176426 |
Q9UI95 | Q9UM11 | 1 | binding | down-regulates activity | 0.544 | The APC is activated in mitosis and G1 by CDC20 and CDH1, and inhibited by the checkpoint protein MAD2, a specific inhibitor of CDC20. We show here that a MAD2 homolog MAD2B also inhibits APC. MAD2B directly inhibits activation of APC by CDC20 and CDH1 | SIGNOR-264902 |
Q96QT4 | P04083 | 1 | phosphorylation | up-regulates | 0.544 | Trpm7 was responsible for phosphorylation of the serine 5 (ser5) residue [29]. In 2009, the study focused on an association between anxa1 and trpm7 confirmed the presence of a trpm7/annexin a1/mg2_+ complex, suggesting a novel pathway in bradykinin signaling, dependent on pkc and c-src [30]. Even though that pathway is... | SIGNOR-202804 |
Q92633 | P50148 | 1 | binding | up-regulates activity | 0.544 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257091 |
P68036 | P46934 | 1 | ubiquitination | up-regulates activity | 0.544 | Only UbcH5 and Related Class I E2s Support Ubiquitination of S5a—UbcH5 belongs to the Class I family of E2s which contains a catalytic core (UBC domain) without a distinct Ub binding domain (38). To test whether other Class I E2s can also support ubiquitination of S5a, we assayed the ubiquitination of S5a with UbcH7 an... | SIGNOR-272735 |
Q9ULX6 | Q08211 | 1 | binding | up-regulates activity | 0.544 | We report evidence for a novel nuclear export signal in HAP95 and showed that the domains involved in RHA binding and nuclear localization are required for CTE activation. Finally, we showed that HAP95 synergizes significantly with RHA on CTE-mediated reporter gene expression and promotes nuclear export of unspliced mR... | SIGNOR-260950 |
Q92823 | P16157 | 1 | relocalization | up-regulates quantity | 0.544 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266721 |
P06241 | Q07666 | 1 | phosphorylation | up-regulates activity | 0.544 | The tyrosine kinase Fyn modulates Sam68 mediated alternative splicing of Bcl-x mRNA.|Tyrosine phosphorylation of Sam68 by Fyn inverted this effect and favored the Bcl-x(L) splice site selection. | SIGNOR-279462 |
P25490 | P01106 | 2 | transcriptional regulation | down-regulates quantity by repression | 0.544 | Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfec... | SIGNOR-268794 |
P18075 | Q13705 | 1 | binding | up-regulates | 0.544 | We show that bmp7 and activin bind to the same type ii receptors, actrii and iib, but recruit distinct type i receptors into heteromeric receptor complexes. | SIGNOR-60240 |
Q70E73 | Q8N8S7 | 1 | binding | up-regulates activity | 0.544 | Here we show that Lpd is a substrate of Abl kinases and binds to the Abl SH2 domain. Phosphorylation of Lpd positively regulates the interaction between Lpd and Ena/VASP proteins. | SIGNOR-268425 |
P45452 | P02458 | 1 | cleavage | down-regulates quantity by destabilization | 0.544 | Although it appears that MMP-1 and MMP-13 both cleave type II collagen initially at the same site, MMP-13 affects a secondary cleavage to produce a 1/4-size collagen fragment with an NH2 terminus three amino acids removed from the primary cleavage site.The present work has demonstrated expression of MMP-13 in human ost... | SIGNOR-256340 |
Q8WWW0 | Q9NS23 | 1 | binding | up-regulates activity | 0.543 | NORE1A can heterodimerize with RASSF1A and, thus, mediate K-Ras regulation of RASSF1A | SIGNOR-249587 |
Q9Y371 | Q14457 | 1 | binding | up-regulates | 0.543 | Bif-1 forms a complex with beclin1 through uvrag and promotes the activation of the class iii pi3 kinase, vps34, in mammalian cells. | SIGNOR-171899 |
Q7Z5H3 | P60953 | 1 | gtpase-activating protein | down-regulates activity | 0.543 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260478 |
P84022 | P46531 | 1 | binding | up-regulates | 0.543 | Nicd and smad3 were shown to interact directly, both in vitro and in cells, in a ligand-dependent manner, and smad3 could be recruited to csl-binding sites on dna in the presence of csl and nicd | SIGNOR-119374 |
O00444 | Q969U6 | 1 | phosphorylation | down-regulates activity | 0.543 | The activity of SCF-FBXW5 is in turn negatively regulated by Polo-like kinase 4 (PLK4), which phosphorylates FBXW5 at Ser 151 to suppress its ability to ubiquitylate HsSAS-6. | SIGNOR-275476 |
Q9UPQ7 | O15146 | 1 | ubiquitination | down-regulates quantity | 0.543 | We have identified a PDZ domain containing RING finger 3 (PDZRN3) as a synapse-associated E3 ubiquitin ligase and have demonstrated that it regulates the surface expression of muscle-specific receptor tyrosine kinase (MuSK), the key organizer of postsynaptic development at the mammalian neuromuscular junction. PDZRN3 b... | SIGNOR-271664 |
O43312 | P08151 | 1 | binding | up-regulates | 0.543 | Mim is a shh-responsive gene that can potentiate gli transcriptional activity.MIM Appears to regulate target gene expression through its association with the gli complex | SIGNOR-157650 |
P15531 | Q8IVT5 | 1 | phosphorylation | down-regulates | 0.543 | Autophosphorylated recombinant nm23-h1 phosphorylated ksr in vitro. Using site-directed mutagenesis, we found that nm23-h1 phosphorylated ksr serine 392, a 14-3-3-binding site, consistent with the recent identification of c-tak1 as a kinase for this site. | SIGNOR-90390 |
P00519 | Q9H3D4 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.543 | In cell lines, upon cisplatin treatment, c-Abl phosphorylates TAp63 on specific tyrosine residues. Such modifications affect p63 stability and induce a p63-dependent activation of proapoptotic promoters. | SIGNOR-260934 |
P06493 | Q5BJF6 | 1 | phosphorylation | up-regulates activity | 0.543 | Phosphorylation of hCenexin1 at S796 is critical for the hCenexin1-Plk1 interaction.Here we show that a splice variant of hODF2 called hCenexin1, but not hODF2 itself, efficiently localizes to somatic centrosomes via a variant-specific C-terminal extension and recruits Plk1 through a Cdc2-dependent phospho-S796 motif w... | SIGNOR-273584 |
P07949 | Q13322 | 1 | binding | up-regulates | 0.543 | Grb7 and grb10, likely relay signals emanating from ret to other, as yet, unidentified targets within the cell | SIGNOR-41699 |
Q15418 | P67809 | 1 | phosphorylation | up-regulates | 0.543 | We therefore conclude that rsk1/rsk2 are novel activators of yb-1, able to phosphorylate the serine 102 residue. | SIGNOR-182497 |
P41143 | P63096 | 1 | binding | up-regulates activity | 0.543 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256683 |
P46695 | Q13362 | 1 | binding | down-regulates | 0.542 | Iex-1 binds to b56 subunits and perk independently, enhances b56 phosphorylation by erk at a conserved ser/pro site in this complex and triggers dissociation from the catalytic subunit. | SIGNOR-144309 |
P25101 | P50148 | 1 | binding | up-regulates | 0.542 | The response to endothelin-1 (et-1) consisted of two phases in both cell types. The initial, transient phase of contraction and phosphorylation of 20-kda myosin light chain (mlc20) was mediated additively by eta and etb receptors and initiated by galphaq-, ca2+/calmodulin-dependent activation of mlc kinase. | SIGNOR-129817 |
Q06187 | O43516 | 1 | phosphorylation | up-regulates activity | 0.542 | Based on previous reports and the present data we suggest that Btk can induce WASP activation and also facilitates its subsequent inactivation through WIP phosphorylation.|We confirmed that Btk can indeed phosphorylate Y468 of baculovirus-generated human His-tagged WIP ( xref ), but that this is more difficult to show ... | SIGNOR-279801 |
Q9UKB1 | P25963 | 1 | ubiquitination | down-regulates | 0.542 | We report here the identification of an ikappab-ubiquitin (ub) ligase complex containing the f-box/wd40-repeat protein, beta-trcp, a vertebrate homolog of drosophila slimb. beta-trcp binds to ikappabalpha only when the latter is specifically phosphorylated by an ikappab kinase complex. here we provide evidence that ly... | SIGNOR-64317 |
P17612 | Q92934 | 1 | phosphorylation | down-regulates | 0.542 | Ser-155 is the major phosphoacceptor site for pka on bad, but that pka also phosphorylates ser-112 and ser-136. Phosphorylated bad appears to be the inactive moiety. These results implicate pkac as the candidate kinase for s112 phosphorylation in vivo. | SIGNOR-67387 |
P27361 | O75030 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.542 | More interestingly, ERK-dependent phosphorylation of MITF at Ser 73 is essential for MITF ubiquitinilation and degradation (87). Putting together all these findings, it can be proposed that MAPK activation inhibits melanogenesis due to an increased MITF degradation which is dependent on the MAPK-induced MITF phosphoryl... | SIGNOR-249620 |
Q05209 | P12931 | 1 | dephosphorylation | up-regulates activity | 0.542 | PTP-PEST increases dephosphorylation of Src at Y527 and activates it.|The data presented here supports our hypothesis that PTP-PEST activates Src via dephosphorylating it at Y527 (Tyr530 in human c-Src equivalent to Tyr527 in chicken Src). | SIGNOR-277086 |
P62136 | Q9GZV5 | 1 | dephosphorylation | up-regulates activity | 0.542 | PP1A dephosphorylates TAZ at Ser-89 and Ser-311, promotes TAZ nuclear translocation, and stabilizes TAZ by disrupting the binding to the SCF E3 ubiquitin ligase. | SIGNOR-277116 |
P53778 | P15336 | 1 | phosphorylation | up-regulates | 0.542 | Our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf-beta signaling via tak1 and p38. The two pathways, smad and tak1, synergistically enhance the activity of atf-2 which acts as their common nuclear target | SIGNOR-65589 |
Q9Y243 | Q92934 | 1 | phosphorylation | down-regulates | 0.542 | Ser-136 is the major phosphoacceptor site for akt;akt can weakly phosphorilate ser-155. | SIGNOR-81122 |
P12931 | Q9Y2X7 | 1 | phosphorylation | up-regulates activity | 0.542 | Tyrosines 246 and 293 are required to hold GIT1 in a closed conformation.Hyperphosphorylation of GIT1-N by Src and pervanadate does not affect its binding in vitro to full length GIT1 proteins. Mutations Y246E and Y293E of GIT1 enhance binding to paxillin. | SIGNOR-276627 |
P27361 | P04150 | 1 | phosphorylation | down-regulates | 0.542 | Cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK) phosphorylate the rat glucocorticoid receptor in vitro at distinct sites that together correspond to the major phosphorylated receptor residues observed in vivo; MAPK phosphorylates receptor residues threonine 171 and serine 246, whereas multiple... | SIGNOR-154409 |
Q9UPT6 | Q13233 | 1 | binding | up-regulates | 0.542 | Overexpression of full-length jsap1 in cos-7 cells led to a considerable enhancement of jnk3 activation, and modest enhancement of jnk1 and jnk2 activation, by the mekk1-sek1 pathwaythe regions of jsap1 that bound jnk, sek1, and mekk1 were distinct from one another. Jnk and mekk1 also bound jsap1 in vitro, suggesting t... | SIGNOR-71471 |
Q8N6P7 | P29597 | 1 | binding | up-regulates | 0.542 | Il-22 activates jak1 and tyk2 | SIGNOR-90165 |
Q99708 | Q96T58 | 1 | binding | down-regulates | 0.542 | We identify the ctip and ctbp corepressors as novel components of the human rbp-jk/sharp-corepressor complex and show that ctip binds directly to the sharp repression domain. | SIGNOR-141616 |
Q13315 | Q9NUW8 | 1 | phosphorylation | up-regulates | 0.542 | Optimal function of the dna repair enzyme tdp1 requires its phosphorylation by atm and/or dna-pk. Here we show that top1-associated dna double-stranded breaks (dsbs) induce the phosphorylation of tdp1 at s81. This phosphorylation is mediated by the protein kinases: ataxia-telangiectasia-mutated (atm) and dna-dependent ... | SIGNOR-188772 |
Q9UBV4 | O75581 | 1 | binding | up-regulates | 0.542 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131677 |
Q9UBS3 | P11021 | 1 | binding | up-regulates activity | 0.542 | When BAP was added to BiP (2:1 molar ratio of BAP:BiP), it increased the ATPase activity of BiP by about 2-fold, which was similar to the increase observed when the J domain of ERdj4 was added to BiP (Fig.5). When both BAP and the J domain were added to BiP, the rate of ATP hydrolysis by BiP was stimulated by about 4-f... | SIGNOR-261044 |
P05412 | P01137 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.542 | MAPKs have cis-acting regulatory elements in the mouse-TGF promoter region, which respond to various transcription factors, including specificity protein-1 and activating protein 1. Thus, it is possible that apoptotic cell-induced TGF-beta mRNA expression is mediated through activation of these transcription factors vi... | SIGNOR-251713 |
Q14004 | P24928 | 1 | phosphorylation | up-regulates activity | 0.541 | Together, these studies demonstrate the important, yet largely redundant, role for CDK12 and CDK13 for the regulation of POLII CTD phosphorylation at multiple residues, as well as the global role for both of these kinases in regulating POLII occupancy across the genome.|CDK12 and CDK13 are thus evolutionarily related a... | SIGNOR-273054 |
P06239 | P06127 | 1 | phosphorylation | up-regulates activity | 0.541 | Tyrosine phosphorylation of cd5 requires lck activity. We propose that t cell activation mediates cd5 tyrosine phosphorylation at residues y429 and y463 mainly through the activation of lck | SIGNOR-106799 |
P21554 | P08754 | 1 | binding | up-regulates activity | 0.541 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256867 |
P63096 | O43306 | 1 | binding | down-regulates activity | 0.541 | Types V and VI adenylyl cyclase are most sensitive to inhibition by Gnai1, Gnai2, and Gnai3 | SIGNOR-278077 |
P08709 | P00742 | 2 | binding | up-regulates activity | 0.541 | TF has a high affinity for FVII and enables the trace levels (∼1% of the total FVII) of activated FVII (FVIIa) in the blood to cleave specific sites in the serine proteases FIX and FX, activating them into FIXa and FXa, respectively. | SIGNOR-263545 |
O14965 | P25963 | 1 | phosphorylation | down-regulates activity | 0.541 | The results of the in vitro kinase assay, using purified human recombinant AURKA and IkappaBalpha proteins, confirmed that AURKA can directly phosphorylate IkappaBalpha (Ser32) at a concentration as low as 2.5 ng/mul (XREF_FIG).|While an earlier study suggested that AURKA down-regulates IkappaBalpha indirectly through ... | SIGNOR-278912 |
P21554 | P63096 | 1 | binding | up-regulates activity | 0.541 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256724 |
Q13459 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.541 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260510 |
Q9UHD2 | Q13568 | 1 | phosphorylation | up-regulates | 0.541 | Activation of interferon regulatory factor 5 by site specific phosphorylation. Although the gene induction by irf5 in the presence of tbk-1 was modest, phosphorylation by tbk-1 produced a significant shift in the mobility of irf5 in sds-page. For this reason we identified the residues that are phosphorylated on irf5 by... | SIGNOR-196528 |
P45984 | Q13469 | 1 | phosphorylation | down-regulates | 0.541 | Jnks directly phosphorylate nuclear factor of activated t-cell (nfat) transcription factors, thus antagonizing the effects of calcium-regulated signaling through the protein phosphatase calcineurin | SIGNOR-118223 |
P0DP24 | Q96RR4 | 1 | binding | up-regulates | 0.541 | The ca2+-calmodulin-dependent protein kinase (cam kinase) cascade includes three kinases: cam-kinase kinase (camkk);and the cam kinases camki and camkiv, which are phosphorylated and activated by camkk. | SIGNOR-266329 |
P28827 | O60716 | 1 | dephosphorylation | down-regulates quantity | 0.541 | Specifically, RPTP\u03bc dephosphorylated p120 catenin, subsequently leading to a lower level of cytoplasmic protein compared with that observed with the vector control and RPTP\u03bc-CS. | SIGNOR-277042 |
P00742 | P08709 | 2 | cleavage | up-regulates activity | 0.541 | The factor VII zymogen is cleaved at arginine 152 by a variety of proteases, including thrombin, factor IXa, factor Xa, and factor VIIa–tissue factor to produce the serine protease factor VIIa. | SIGNOR-263523 |
Q96HW7 | P24928 | 1 | binding | up-regulates activity | 0.541 | The Integrator Complex Can Directly Associate with the C-Terminal Domain of RNA Polymerase II Largest Subunit | SIGNOR-261185 |
O00221 | P19838 | 1 | binding | down-regulates | 0.541 | Nf-kb is normally sequestered in the cell cytoplasm by binding to ikbx, ikbb, ikbe | SIGNOR-102774 |
P53041 | P04150 | 1 | dephosphorylation | down-regulates activity | 0.541 | Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation.|Inhibition of GR phosphorylation at Ser-211 is associated with decreased nuclear retention of GR and decreased gene transcription. | SIGNOR-248538 |
Q9Y3C5 | Q9HAU4 | 1 | binding | up-regulates activity | 0.54 | RNF11 recruits AMSH to Smurf2 E3 ligase. Smurf2 promotes ubiquitination of AMSH in the presence of wt RNF11. Previously, we have shown that RNF11 interacts with the HECT-type E3 ligases AIP4 and Smurf2. Here, we show that RNF11 binds to AMSH in mammalian cells and that this interaction is independent of the RNF11 RING-... | SIGNOR-272952 |
Q02363 | P15172 | 1 | binding | down-regulates activity | 0.54 | Id1 and Id2 interacted strongly with MyoD and Myf-5.Each Id was able to disrupt the ability of E protein-MyoD complexes to transactivate from a muscle creatine kinase reporter construct in vivo. | SIGNOR-240268 |
P06493 | Q9UNH5 | 1 | phosphorylation | up-regulates activity | 0.54 | We found that Cdc14A is phosphorylated on Ser411, Ser453 and Ser549 by Cdk1 early in mitosis and becomes dephosphorylated during late mitotic stages. | SIGNOR-278264 |
Q15910 | P10275 | 1 | binding | up-regulates activity | 0.54 | This study demonstrates that phosphorylation of EZH2 at Ser21, mediated directly or indirectly by the PI3K-Akt pathway, can switch its function from a Polycomb repressor to a transcriptional coactivator of AR (and potentially other factors). | SIGNOR-251542 |
P62258 | P46527 | 1 | binding | down-regulates | 0.54 | 14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. | SIGNOR-88297 |
P51151 | Q8IWJ2 | 1 | null | up-regulates activity | 0.54 | Rab9-dependent transport from late endosomes to the Golgi requires the Rab9 effectors p40 (Diaz et al., 1997) and TIP47 (Diaz and Pfeffer, 1998), a protein that recognizes the cytoplasmic domains of the two types of MPRs and packages them into nascent transport vesicles (Carroll et al., 2001). MPR recycling also utiliz... | SIGNOR-253087 |
Q99933 | Q9UNE7 | 1 | binding | up-regulates activity | 0.54 | BAG-1 stimulates CHIP-induced degradation of the glucocorticoid hormone receptor (GR). A model for the cooperation of CHIP and BAG-1 in coupling Hsc/Hsp70 to the ubiquitin/proteasome system. CHIP associates with Hsc/Hsp70 via its TPR chaperone adaptor (TPR) and, at the same time, recruits E2 ubiquitin-conjugating enzym... | SIGNOR-272587 |
Q8TDJ6 | Q15042 | 1 | binding | up-regulates quantity | 0.54 | We isolated here a novel protein that was co-immunoprecipitated with Rab3 GEP and GAP by their respective antibodies from the crude synaptic vesicle fraction of rat brain. The protein, named rabconnectin-3, bound both Rab3 GEP and GAP. These results indicate that rabconnectin-3 serves as a scaffold molecule for both R... | SIGNOR-265582 |
Q13164 | P17302 | 1 | phosphorylation | down-regulates activity | 0.54 | Activated BMK1 selectively phosphorylates Cx43 on Ser-255 in vitro and in vivo. These data demonstrate that BMK1 kinase activity alone is both a necessary and sufficient component in the mediation of EGF-induced Cx43 Ser-255 phosphorylation and subsequent inhibition of GJC. | SIGNOR-250115 |
P49841 | P04150 | 1 | phosphorylation | down-regulates activity | 0.54 | We found hormone-dependent GR phosphorylation on serine 404 by GSK-3beta [ ]Cells expressing a GR that is incapable of GSK-3beta phosphorylation had a redirection of the global transcriptional response to hormone, including the activation of additional signaling pathways, in part due to the altered ability of unphospho... | SIGNOR-181541 |
O15111 | Q13546 | 1 | phosphorylation | down-regulates activity | 0.54 | Indeed, IKKa and IKKb may directly repress RIPK1 kinase activity by addition of an inhibitory phosphate group on RIPK1.|Mass spectrometry analysis of kinase assays performed with recombinant proteins allowed us to identify Ser166, Ser331, and Ser416 as highly conserved RIPK1 residues phosphorylated by IKKa and IKKb. | SIGNOR-278927 |
P51449 | Q16552 | 1 | transcriptional regulation | up-regulates | 0.54 | We found that RORgt is required for the constitutive expression of IL-17 in intestinal lamina propria T cells and for the in vitro differentiation of Th17 cells from naive CD4+ T cells | SIGNOR-255029 |
Q12923 | P12931 | 1 | dephosphorylation | down-regulates activity | 0.54 | Mechanistically, RIL suppresses Src activation through interacting with Src and PTPL1, allowing PTPL1 dependent dephosphorylation of Src at the activation loop.|Our results reveal a novel Src inactivation cycle in which reversion-induced LIM preferentially recognizes active Src and facilitates PTPL1-mediated inactivati... | SIGNOR-277125 |
Q00535 | Q13153 | 1 | phosphorylation | down-regulates activity | 0.54 | Our previous work revealed that the neuronal p35/Cdk5 kinase associates with Pak1 in a RacGTP-dependent manner, causing hyperphosphorylation and down-regulation of Pak1 kinase activity. We have now demonstrated direct phosphorylation of Pak1 on threonine 212 by the p35/Cdk5 kinase. | SIGNOR-249328 |
P50750 | P01106 | 1 | phosphorylation | down-regulates activity | 0.54 | CDK9 promotes phosphorylation of MYC on Ser 62 . | SIGNOR-279024 |
Q09013 | P26678 | 1 | phosphorylation | up-regulates | 0.54 | Coimmunoprecipitation studies showed that dmpk and pln can physically associate. Furthermore, purified wild-type dmpk, but not a kinase-deficient mutant (k110a dmpk), phosphorylates pln in vitro | SIGNOR-131371 |
Q16816 | P06737 | 1 | phosphorylation | up-regulates activity | 0.54 | It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 | SIGNOR-267399 |
P04629 | Q9NRF2 | 1 | binding | up-regulates | 0.54 | The adapter protein sh2-b has been shown to bind to activated nerve growth factor (ngf) receptor trka and has been implicated in ngf-induced neuronal differentiation and the survival of sympathetic neurons. | SIGNOR-124198 |
Q13627 | Q96EB6 | 1 | phosphorylation | up-regulates activity | 0.54 | DYRK1A and DYRK3 directly phosphorylate SIRT1 at Thr(522), promoting deacetylation of p53.|DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. | SIGNOR-278473 |
Q13976 | Q01970 | 1 | phosphorylation | down-regulates activity | 0.539 | PKG can directly phosphorylate PLC-beta2 and PLC-beta3 in vitro with purified proteins and in vivo with metabolic labeling. Phosphorylation of PLC-beta leads to the inhibition of G-protein-activated PLC-beta3 activity by 50-70% in COS-7 cell transfection assays. By using phosphopeptide mapping and site-directed mutagen... | SIGNOR-249077 |
P28482 | Q05682 | 1 | phosphorylation | down-regulates | 0.539 | Extracellular signal-regulated kinases (erks) phosphorylate the high molecular mass isoform of the actin-binding protein caldesmon (h-cad) at two sites (ser(759) and ser(789)) during smooth muscle stimulation. Nmr spectroscopy shows that the actin binding properties of the minimal inhibitory region of caldesmon, residu... | SIGNOR-71037 |
P42224 | P33076 | 1 | transcriptional regulation | up-regulates | 0.539 | When IFN-γ binds to its receptor, the receptor-associated protein tyrosine kinases Janus kinase I (JAK1) and JAK2 are activated (37). This leads to the phosphorylation of STAT1, which then dimerizes, translocates to the nucleus, and activates its target promoters, including the pIV promoter of Ciita | SIGNOR-256249 |
P53350 | P51587 | 1 | phosphorylation | down-regulates activity | 0.539 | M phase-specific phosphorylation of brca2 by polo-like kinase 1 correlates with the dissociation of the brca2-p/caf complex.Plk1 interacts with brca2 in vivo, and mutation of ser193, ser205/206, and thr203/207 to ala in br-n1 abolished plk1 phosphorylation, suggesting that brca2 is the substrate of plk1 | SIGNOR-102486 |
P38405 | Q08828 | 1 | binding | up-regulates activity | 0.539 | D1-class dopamine receptors (D1 and D5) activate the G s/olf family of G proteins to stimulate cAMP produc tion by AC and are found exclusively postsynaptically on dopamine-receptive cells, such as GABA-ergic medium spiny neurons (MSNs) in the striatum. | SIGNOR-264992 |
Q9ULT6 | Q9H461 | 1 | ubiquitination | down-regulates quantity | 0.539 | Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6. | SIGNOR-260111 |
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