IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q13315 | Q9BQ15 | 1 | phosphorylation | up-regulates activity | 0.501 | Ataxia telangiectasia mutated (ATM) kinase phosphorylates hSSB1 in response to DNA double-strand breaks (DSBs). This phosphorylation event is required for DNA damage-induced stabilization of hSSB1. | SIGNOR-262639 |
Q15642 | Q68EM7 | 1 | binding | down-regulates activity | 0.501 | Screening for potential mediators of this effect resulted in the identification of the Rac1-specific GTPase-activating protein ARHGAP17 and the guanine nucleotide exchange factor ARHGEF6 as new PKA and PKG substrates in platelets. We mapped the PKA/PKG phosphorylation sites to serine 702 on ARHGAP17 using Phos-tag gels... | SIGNOR-272158 |
O96018 | P61764 | 1 | binding | up-regulates activity | 0.501 | Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. | SIGNOR-264036 |
P27361 | P10636-2 | 1 | phosphorylation | down-regulates activity | 0.501 | We have studied the relationship between the phosphorylation oftau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. By contrast, MARK and PKA phosphorylate several sites within the repeats (notably theKXGS motifs including Ser262, Ser324, and Ser356, plus Ser320); in addition PKA phosphorylates so... | SIGNOR-275434 |
O95271 | Q92530 | 1 | ADP-ribosylation | down-regulates quantity by destabilization | 0.501 | We identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31. TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. | SIGNOR-263387 |
Q13237 | P48436 | 1 | phosphorylation | down-regulates activity | 0.501 | Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines|Prkg2 transfected glioma cell lines express a functional cGKII that can phosphorylate VASP and Sox9. | SIGNOR-278985 |
O15034 | Q86UR5 | 1 | binding | down-regulates activity | 0.501 | SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. | SIGNOR-264361 |
Q14680 | Q08050 | 1 | phosphorylation | up-regulates activity | 0.501 | MELK Activates FOXM1 Transcriptional Activity Leading to Upregulation of Mitotic Gene Expression.|The autoradiogram clearly shows in vitro phosphorylation of FOXM1 by MELK and CDK2 and cyclinA. | SIGNOR-278412 |
Q96IZ0 | P19544 | 1 | binding | down-regulates activity | 0.501 | We identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcriptional repressor. Functionally, par-4 inhibited transcription activated by WT1 | SIGNOR-240596 |
Q96K83 | Q9UH73 | 1 | binding | down-regulates | 0.501 | Ehzf inhibits the transcriptional activity of early b-cell factor (ebf), a transcription factor essential for specification of the b-cell lineage /ability to interact with the neural and hematopoietic transcription factor olf1/ebf1 and inhibit its binding to dna | SIGNOR-119300 |
Q13261 | P52333 | 1 | null | up-regulates | 0.501 | Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly ... | SIGNOR-256226 |
Q9C0H5 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.501 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260494 |
P05771 | P48736 | 1 | phosphorylation | up-regulates activity | 0.501 | Remarkably we find that PKCβ phosphorylates Ser582 in the helical domain of the PI3Kγ catalytic subunit p110γ in response to clustering of the high-affinity IgE receptor (FcεRI) and/or store-operated Ca²⁺- influx in mast cells. Phosphorylation of p110γ correlates with the release of the p84 PI3Kγ adapter subunit from ... | SIGNOR-276496 |
P62136 | P30307 | 1 | binding | up-regulates | 0.501 | Pp1 recognizes cdc25 directly by interacting with a pp1-binding motif in the cdc25 n-terminus. | SIGNOR-118917 |
P06239 | Q9H4E7 | 1 | phosphorylation | up-regulates activity | 0.5 | In vitro kinase assays indeed demonstrated that Lck can phosphorylate wild-type IBP but not the Y210F mutant. IBP Binds PI(3,4,5)P3 upon Phosphorylation by Lck | SIGNOR-251372 |
O14595 | Q15797 | 1 | dephosphorylation | down-regulates | 0.5 | In human cells, rnai-mediated depletion of scp1 and scp2 increases the extent and duration of smad1 phosphorylation in response to bmp, the transcriptional action of smad1, and the strength of endogenous bmp gene responses. The present identification of the scp family as smad c-terminal phosphatases sheds light on the ... | SIGNOR-148434 |
P42127 | P33032 | 1 | binding | down-regulates activity | 0.5 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268713 |
P01112 | P05412 | 1 | phosphorylation | up-regulates activity | 0.5 | c-Jun was first shown to be phosphorylated in its transactivation domain (Ser-63 and Ser-73) by ERKs and p54-JNK. This is consistent with other studies which show that PD98059 inhibits up-regulation of c-Jun protein in Ras-transformed NIH-3T3 cells | SIGNOR-235522 |
P17612 | P04049 | 1 | phosphorylation | down-regulates activity | 0.5 | Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. Cyclic AMP (cAMP) blocks Raf-1 activation by stimulating its phosphorylation on serine 43 (Ser43), serine 233 (Ser233), and serine 259 (Ser259). | SIGNOR-250041 |
P52306 | P15153 | 1 | binding | up-regulates | 0.5 | Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob | SIGNOR-171421 |
Q9UBY5 | O95837 | 1 | binding | up-regulates activity | 0.5 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257357 |
P45983 | P22736 | 1 | phosphorylation | down-regulates | 0.5 | We also identified the exact phosphorylation site of jnk to be serine 95 at the n terminus of tr3, around which a classical jnk phosphorylation motif exists. Furthermore, we demonstrated that tr3 phosphorylation by jnk coincided with its ubiquitination and degradation, resulting in the loss of its mitogenic activity. | SIGNOR-149998 |
P49841 | Q07820 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.5 | MCL-1 was phosphorylated by GSK-3 at a conserved GSK-3 phosphorylation site (S159). S159 phosphorylation of MCL-1 was induced by IL-3 withdrawal or PI3K inhibition and prevented by AKT or inhibition of GSK-3, and it led to increased ubiquitinylation and degradation of MCL-1. | SIGNOR-251242 |
P42127 | P32245 | 1 | binding | down-regulates activity | 0.5 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268708 |
P28482 | P19438 | 1 | phosphorylation | down-regulates activity | 0.5 | Phosphorylation of murine CD120a by p42(mapk/erk2) has been shown to inhibit its ability to initiate apoptosis while preserving signaling events such as NF-kappaB activation.|Additionally, we demonstrated that (i) the p42(mapk/erk2)-dependent phosphorylation of CD120a and DR3 occurred on Ser and Thr residues, (ii) p42(... | SIGNOR-249453 |
Q96JP5 | Q99558 | 1 | ubiquitination | up-regulates | 0.5 | Zfp91 interacts with and promotes the lys(63)-linked ubiquitination of nik and subsequent processing of p100 to p52. | SIGNOR-167331 |
O00506 | Q9BSQ5 | 1 | phosphorylation | up-regulates | 0.5 | CCM2 can be phosphorylated by STK25, and the kinase activity of STK25 is required for death signaling. | SIGNOR-263144 |
P04150 | O15055 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.5 | GR directly regulates transcription of circadian clock components in mouse and human primary MSCs. Per2, E4bp4, Per1, and Timeless rapidly respond to glucocorticoid stimulation. Primary glucocorticoid receptor (GR) target genes are those at which GR occupies a nearby genomic glucocorticoid response element (GRE) and re... | SIGNOR-268049 |
Q92973 | P49790 | 1 | relocalization | up-regulates activity | 0.499 | TNPO1 only mediates the nuclear import of a subset of proteins.|Among TNPO1 cargos, the most extensively characterized is the RNA binding protein heterogeneous nuclear ribonucleoprotein 1 (hnRNPA1) (27), which functions in several processes including mRNA biogenesis and promotion of transcription factor activity (28–30... | SIGNOR-262100 |
Q969F8 | P50148 | 1 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256750 |
P55291 | Q4KMG0 | 1 | binding | up-regulates activity | 0.499 | Cdo binds promyogenic cadherins form complexes with n- and m-cadherin. | SIGNOR-99250 |
O15013 | P60953 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.499 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260537 |
Q9UKE5 | P06396 | 1 | phosphorylation | up-regulates activity | 0.499 | In vitro , TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly ( xref ).|In vitro, TNIK can phosphorylate and activate the F-actin-fragmenting enzyme gelsolin, and in cultured cells, TNIK induces actin fiber disassembly. | SIGNOR-280154 |
P33981 | P04637 | 1 | phosphorylation | up-regulates | 0.499 | Ttk/hmps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at thr18. phosphorylation at thr18 enhances p53-dependent activation of not only p21 but also lats2, two mediators of the postmitotic checkpoint. | SIGNOR-184931 |
P30556 | P30679 | 1 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257223 |
Q969H0 | Q99466 | 1 | ubiquitination | down-regulates | 0.499 | We show here that the f-box/wd40 repeat protein sel-10 negatively regulates notch receptor activity by targeting the intracellular domain of notch receptors for ubiquitin-mediated protein degradation. in conclusion, hsel-10 physically associates with mouse notch4(int-3) through the wd40 domain, whereas the f-box domai... | SIGNOR-110955 |
Q9ULW0 | P52732 | 1 | binding | down-regulates activity | 0.499 | Dimeric, but not monomeric, Eg5 was differentially inhibited by full-length and truncated TPX2, demonstrating that dimerization or residues in the neck region are important for the interaction of TPX2 with Eg5. | SIGNOR-265097 |
Q13315 | Q5UIP0 | 1 | binding | up-regulates activity | 0.499 | Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. After induction of double-strand breaks (DSBs), Rif1 formed foci that colocalized with other DNA-damage-response factors. This response was strictly dependent on ATM (ataxia telangiectasia mutated) ... | SIGNOR-259059 |
P02679 | P04275 | 1 | binding | down-regulates activity | 0.499 | Fibrinogen y-chain carboxyterminal (GQQHHLGGAKQAGDV) peptides inhibit fibrinogen, fibronectin (Fn), vitronectin, and von Willebrand factor (vWF) binding to the platelet glycoprotein Ilb-Illa complex (GP lIbII1a). | SIGNOR-251968 |
P35453 | O00470 | 1 | binding | up-regulates activity | 0.499 | We now show that the Hoxa-9 protein physically interacts with Meis1 proteins. Hox proteins from the other AbdB-like paralogs, Hoxa-10, Hoxa-11, Hoxd-12, and Hoxb-13, also form DNA binding complexes with Meis1b. DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with ... | SIGNOR-241235 |
Q92734 | Q96JE7 | 1 | binding | up-regulates | 0.499 | We identify tfg-1, a new conserved regulator of protein secretion that interacts directly with sec-16 and controls the export of cargoes from the endoplasmic reticulum in caenorhabditis elegans. Hydrodynamic studies indicate that tfg-1 forms hexamers that facilitate the co-assembly of sec-16 with copii subunits. | SIGNOR-173279 |
P17481 | P40424 | 1 | binding | up-regulates activity | 0.499 | the ability of HoxB8 to heterodimerizes with endogenous Pbx proteins on DNA alters gene transcription in a manner that prevents progression through an intrinsic genetic differentiation program. In conjunction with Pbx, HoxB8 could alter transcription of Pbx target genes by direct or indirect mechanisms. | SIGNOR-223153 |
P25103 | P50148 | 1 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257374 |
Q9ULW0 | Q7Z460 | 1 | binding | up-regulates activity | 0.499 | Phosphorylation of TPX2 regulated its interaction with CLASP1 but not Kif2a.|This suggests that TPX2 phosphorylation positively regulates the function of CLASP1.| This is in accord with a phosphoproteomics study that identified S121 and S125 as potential phosphorylation sites for Aurora A in mitotic HeLa cells | SIGNOR-265090 |
Q13315 | Q9UER7 | 1 | phosphorylation | down-regulates | 0.499 | The main phosphorylation site of daxx is identified to be ser564, which is a direct target of atm. Phosphorylation of endogenous daxx at ser564 occurs rapidly during the dna damage response and precedes p53 activation. Blockage of this phosphorylation event prevents the separation of daxx from mdm2, stabilizes mdm2, an... | SIGNOR-200889 |
Q13191 | O00459 | 1 | ubiquitination | down-regulates activity | 0.499 | Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. it can be postulated that Cbl-b, as an E3 Ub ligase, may play a general role in functional regulation of its target proteins through ubiquitination in a protein degradation-independent manner. | SIGNOR-271424 |
P42681 | P16410 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.498 | We demonstrate that rlk (resting lymphocyte kinase) is capable of phosphorylating ctla-4 at the yvkm motif. Consistent with this finding, rlk is capable of providing conditions for the binding of the sh2 domains of pi 3-kinase to the receptor. Ctla-4 is therefore the first known substrate for rlk suggesting the possibi... | SIGNOR-61624 |
Q9BYP7 | Q13621 | 1 | phosphorylation | up-regulates activity | 0.498 | We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activ... | SIGNOR-264626 |
P48039 | P08754 | 1 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256849 |
O15194 | Q15796 | 1 | dephosphorylation | down-regulates activity | 0.498 | Dephosphorylation of Smad2/3 Linkers by SCP2 and SCP3|MAPK-mediated linker phosphorylation appears to have a dual role in Smad2/3 regulation. Mitogens and hyperactive Ras result in extracellular signal-regulated kinase (ERK)-mediated phosphorylation of Smad3 at Ser-204, Ser-208, and Thr-179 and of Smad2 at Ser-245/250/... | SIGNOR-248310 |
O15194 | Q15797 | 1 | dephosphorylation | down-regulates activity | 0.498 | Smad proteins transduce bone morphogenetic protein (BMP) and transforming growth factor-beta (TGFbeta) signals upon phosphorylation of their C-terminal SXS motif by receptor kinases.|Phosphatases that dephosphorylate the linker region are therefore likely to play an integral part in the regulation of Smad activity. We ... | SIGNOR-248314 |
P21728 | P63092 | 1 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256796 |
Q4KMG0 | O60271 | 1 | binding | up-regulates activity | 0.498 | In this study, we report that the cdo intracellular region interacts with jlp, a scaffold protein for the p38alpha/beta mapk pathway. | SIGNOR-150282 |
Q9GZU7 | Q15797 | 1 | dephosphorylation | down-regulates | 0.498 | In human cells, rnai-mediated depletion of scp1 and scp2 increases the extent and duration of smad1 phosphorylation in response to bmp, the transcriptional action of smad1, and the strength of endogenous bmp gene responses. The present identification of the scp family as smad c-terminal phosphatases sheds light on the ... | SIGNOR-148396 |
Q05513 | P31751 | 1 | phosphorylation | up-regulates activity | 0.498 | The activation of PKBbeta and PKBgamma by PDK1 was accompanied by the phosphorylation of the residues equivalent to Thr308 in PKBalpha, namely Thr309 (PKBbeta) and Thr305 (PKBgamma). PKBgamma which had been activated by PDK1 possessed a substrate specificity identical with that of PKBalpha and PKBbeta towards a range o... | SIGNOR-248997 |
Q5VST9 | Q01484 | 1 | relocalization | up-regulates quantity | 0.498 | Ankyrin-B is targeted to the M-line via its interaction with the C-terminal domain of the large sarcomeric protein obscurin. Obscurin is targeted to the M-line via its N-terminal interactions with myomesin and titin. This population of ankyrin-B recruits B56α, a regulatory subunit of protein phosphatase 2A, to the M-li... | SIGNOR-266726 |
Q9NRC8 | P04637 | 1 | deacetylation | down-regulates | 0.498 | We found that sirt7 interacts with p53 and efficiently deacetylates p53 in vitro, which corresponds to hyperacetylation of p53 in vivo. | SIGNOR-160539 |
P68400 | Q96HZ4 | 1 | phosphorylation | up-regulates activity | 0.498 | Hes6 inhibits the interaction of Hes1 with its transcriptional corepressor Gro/TLE. Moreover, it promotes proteolytic degradation of Hes1. This effect is maximal when both Hes1 and Hes6 contain the WRPW motif and is reduced when Hes6 is mutated to eliminate a conserved site (Ser183) that can be phosphorylated by protei... | SIGNOR-250890 |
P42345 | P03372 | 1 | phosphorylation | up-regulates activity | 0.498 | Thus our results indicate that the interaction between ER\u03b1 and raptor is necessary to recruit raptor to the nucleus, where mTOR phosphorylates and activates ER\u03b1. | SIGNOR-278295 |
P17612 | Q13936 | 1 | phosphorylation | up-regulates activity | 0.498 | These findings reveal an essential role for _1C phosphorylation at Ser1928 in stimulating CaV1.2 channel activity and vasoconstriction by AKAP-targeted PKA upon exposure to increased glucose and in diabetes | SIGNOR-251709 |
Q00987 | P61254 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.498 | In addition, Mdm2 ubiquitylates L26, leading to its proteasome-mediated degradation.|We now report that Mdm2 regulates p53 levels also by targeting ribosomal protein L26. | SIGNOR-278828 |
Q9BX84 | Q96QT4 | 1 | phosphorylation | down-regulates quantity | 0.498 | We found TRPM6 and TRPM7 both autophosphorylate threonine residues, but only TRPM6 crossphosphorylates TRPM7, and not the reverse . | SIGNOR-279770 |
Q01850 | P01106 | 1 | binding | up-regulates activity | 0.498 | Here we find that cdr2 is cell cycle regulated in tumor cells with protein levels peaking in mitosis. As cells exit mitosis, cdr2 is ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) and rapidly degraded by the proteasome. Previously we showed that cdr2 binds to the oncogene c-myc, and here we extend th... | SIGNOR-252000 |
P54646 | O00418 | 1 | phosphorylation | up-regulates activity | 0.498 | Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398. phosphorylation of eEF2 kinase at Ser-398 leads to an increase in its activity. | SIGNOR-250158 |
P42127 | Q01718 | 1 | binding | down-regulates activity | 0.498 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanoc... | SIGNOR-268695 |
O14827 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.498 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260574 |
P08631 | Q13905 | 1 | phosphorylation | up-regulates | 0.498 | We also showed that ctla-4 receptor signaling mediates tyrosine phosphorylation in the c3g protein, and that this is required for augmented activation of rap1 and increased adhesion mediated by leukocyte function-associated antigen type 1 (lfa-1). ctla-4 signaling leads to phosphorylation of c3g tyrosine 504. the src... | SIGNOR-203613 |
P43115 | P16520 | 1 | binding | up-regulates | 0.498 | Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i) | SIGNOR-88192 |
Q13490 | P42575 | 1 | binding | down-regulates | 0.498 | However, among hiap1, hiap2 and xiap, only hiap2 binds and inhibits caspase-2. | SIGNOR-146738 |
P06493 | P27816 | 1 | phosphorylation | down-regulates activity | 0.497 | We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-poly... | SIGNOR-277459 |
P36894 | O00238 | 1 | binding | up-regulates | 0.497 | Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known bmp type i receptors | SIGNOR-75649 |
P06493 | P38398 | 1 | phosphorylation | up-regulates | 0.497 | However, shrna-mediated depletion of cdk1 alone or small molecule cdk1 inhibition abrogated s phase cell-cycle arrest and the phosphorylation of a subset of atr/atm targets after dna damage. Loss of dna damage-induced checkpoint control was caused by a reduction in formation of brca1-containing foci. Mutation of brca1 ... | SIGNOR-72087 |
Q13639 | P63092 | 1 | binding | up-regulates activity | 0.497 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256769 |
P31749 | Q5VWQ8 | 1 | phosphorylation | down-regulates activity | 0.497 | DAB2IP can be phosphorylated by RIP1 on Ser 604 within the PER domain, and by AKT1 on Ser 847 within the proline-rich domain. Although RIP1-mediated phosphorylation is stimulatory,40 a recent study reported that AKT-mediated phosphorylation inhibits DAB2IP functions | SIGNOR-254780 |
O43541 | P84022 | 1 | binding | down-regulates activity | 0.497 | Smad6 and smad7, can prevent tgfb signaling by interacting either with the receptor or with smad2 and smad3 | SIGNOR-64071 |
P08581 | Q05397 | 1 | phosphorylation | up-regulates | 0.497 | Met-mediated fak phosphorylation could further activate fak. Indeed, we found that met phosphorylates fak at its known phosphorylation sites, including tyr-576 and tyr-577, both of which are located in the activating loop within the catalytic domain | SIGNOR-147199 |
Q15303 | Q92529 | 1 | relocalization | up-regulates | 0.497 | Like erbb1, erbb4 recruits grb2, shc and stat5. | SIGNOR-147850 |
Q99750 | P15172 | 1 | binding | down-regulates activity | 0.497 | We demonstrate that I-mf inhibits the transactivation activity of the MyoD family and represses myogenesis. I-mf associates with MyoD family members and retains them in the cytoplasm by masking their nuclear localization signals. | SIGNOR-240436 |
P53355 | Q13224 | 1 | phosphorylation | up-regulates activity | 0.497 | DAPK1 Activation Enhances the NR1 and NR2B Channel Conductance.|Thus, an activated DAPK1 enhances NR1 and NR2B receptor channel conductance by phosphorylating NR2B subunit at Ser 1303. | SIGNOR-278397 |
Q13315 | P50542 | 1 | phosphorylation | up-regulates activity | 0.497 | Specificity for autophagy of peroxisomes (pexophagy) is provided by ATM phosphorylation of PEX5 at Ser 141, which promotes PEX5 monoubiquitylation at Lys 209, and recognition of ubiquitylated PEX5 by the autophagy adaptor protein p62, directing the autophagosome to peroxisomes to induce pexophagy. | SIGNOR-262792 |
Q08881 | Q06187 | 2 | phosphorylation | down-regulates activity | 0.497 | Btk-SH3 mutant Y223A was not phosphorylated by Itk. Tec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop.|In Btk, the SH3 domain mutation Y223F results in enhanced fibr... | SIGNOR-251333 |
O75182 | P04637 | 1 | binding | down-regulates activity | 0.497 | The present study shows that under bleomycin-induced stress, expression of Sin3B gets up-regulated and it gets recruited by p53 at its target promoters. Knockdown of Sin3B leads to impaired negative regulation of p53 target genes and thus exemplifies Sin3B as a critical player in down-regulation of p53 subset target ge... | SIGNOR-266776 |
Q00535 | Q8IWU2 | 1 | phosphorylation | up-regulates | 0.497 | Here, we demonstrate that lmtk2 is phosphorylated on serine-1418 (lmtk2ser ) by cdk5/p35 and present evidence that this regulates its ability to phosphorylate pp1cthr __ | SIGNOR-195329 |
O43150 | P84085 | 1 | gtpase-activating protein | up-regulates activity | 0.497 | Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. In addition, in vitro recombinant Pap exhibits strong GTPase-activating prot... | SIGNOR-269707 |
Q8NI17 | P23458 | 1 | binding | up-regulates | 0.497 | Il-31 can activate janus kinase (jak) 1 and jak2 signaling molecules after binding to its receptor complex. | SIGNOR-161342 |
Q12967 | Q13671 | 1 | binding | up-regulates activity | 0.497 | Rit and Rin were found to interact with the known Ras binding proteins RalGDS, Rlf, and AF-6/Canoe. These interactions were GTP and effector domain dependent and suggest that RalGDS, Rlf, and AF-6 are Rit and Rin effectors. | SIGNOR-220923 |
P28482 | P24941 | 1 | phosphorylation | up-regulates | 0.497 | In addition to its role in stimulating cyclin d1 expression and nuclear translocation of cdk2, erk regulates thr-160 phosphorylation of cdk2-cyclin e. | SIGNOR-94003 |
Q06187 | Q08881 | 2 | phosphorylation | up-regulates | 0.497 | Tec family protein tyrosine kinases (tfks) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the sh3 domain via a transphosphorylation mechanismthe major phosphorylation site... | SIGNOR-98036 |
Q14190 | P27540 | 1 | binding | up-regulates activity | 0.497 | We demonstrate that both SIM1 and SIM2 can heterodimerize via their helix-loop-helix·PAS regions with ARNT, but not with AHR, and that they do not form homodimers. Furthermore, SIM1 may have a dual role, both negatively affecting AHR·ARNT binding to the XRE and also acting in concert with ARNT as a novel DNA-binding he... | SIGNOR-240808 |
P45983 | Q00613 | 1 | phosphorylation | down-regulates activity | 0.497 | JNK is activated by heat shock and phosphorylates HSF-1 on serine 363. JNK Phosphorylation of HSF-1 Leads to Reduction in Its Transcriptional Activity | SIGNOR-250119 |
Q96JM3 | Q9UI95 | 1 | binding | up-regulates activity | 0.497 | Here, we report a novel regulator for accurate chromosome segregation, chromosome alignment-maintaining phosphoprotein (CAMP). We identified CAMP as a MAD2L2-interacting protein. Spindle localization of MAD2L2 was abrogated by CAMP depletion (Supplementary Figure S2A) | SIGNOR-264904 |
Q9Y6W8 | P27986 | 1 | binding | up-regulates activity | 0.497 | ICOS ligation in concert with TCR stimulation results in strong PI3K activation in T lymphocytes. The ICOS cytoplasmic tail contains an YMFM motif that binds the p85alpha subunit of class IA PI3K, similar to the YMNM motif of CD28, suggesting a redundant function of the two receptors in PI3K signaling. | SIGNOR-272539 |
Q9P2Y5 | Q6NUQ1 | 1 | binding | up-regulates activity | 0.497 | We further show that UVRAG interacts with RINT-1, and acts as an integral component of the RINT-1-containing ER tethering complex, which couples phosphoinositide metabolism to COPI-vesicle tethering. Displacement or knockdown of UVRAG profoundly disrupted COPI cargo transfer to the ER and Golgi integrity | SIGNOR-265028 |
P41225 | P35222 | 1 | binding | down-regulates | 0.497 | Two additional sox proteins, xsox17alfa and xsox3, likewise bind to beta-catenin and inhibit its tcf-mediated signaling activity. | SIGNOR-72039 |
O14733 | Q13158 | 1 | phosphorylation | down-regulates activity | 0.497 | The results clearly show that fadd phosphorylation at ser194 affects functions both upstream and downstream of the mekk1/mkk7/jnk1 pathway and is closely associated with chemosensitivity in prostate cancer cells | SIGNOR-123164 |
P31749 | Q99490 | 1 | phosphorylation | up-regulates | 0.497 | In addition, we have found that activated akt can bind and phosphorylate ggap2 at serine 629, which enhances gtp binding by ggap2. | SIGNOR-183543 |
Q92733 | Q9UI95 | 1 | relocalization | up-regulates | 0.496 | We found that the human papillary renal cell carcinoma-associated proteinprccinteracts with the cell cycle control proteinmad2b, and translocates this protein to the nucleus where it exerts its mitotic checkpoint function. | SIGNOR-126516 |
P12931 | P46527 | 1 | phosphorylation | down-regulates | 0.496 | Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Our data indicate that phosphorylation by src impairs the cdk2 inhibitory action of p27 | SIGNOR-152839 |
Q06187 | P42680 | 2 | phosphorylation | up-regulates | 0.496 | Tec family protein tyrosine kinases (tfks) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the sh3 domain via a transphosphorylation mechanism. Here, we could confirm that ... | SIGNOR-98086 |
P42680 | Q06187 | 2 | phosphorylation | down-regulates activity | 0.496 | Tec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the SH3 domain via a transphosphorylation mechanism, which for Bruton's tyrosine ... | SIGNOR-246652 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.