IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q9UHI6 | P58012 | 1 | binding | up-regulates | 0.445 | Dp103 further increased the cell killing effect induced by foxl2 probably due to the direct association of dp103 with foxl2 protein. | SIGNOR-140388 |
Q12955 | O95166 | 1 | binding | up-regulates activity | 0.445 | Importantly, the 480 kDa ankyrin-G isoform has also been shown to stabilize GABAergic synapses on the soma and AIS of excitatory pyramidal neurons by interacting with the GABAA receptor-associated protein (GABARAP) to inhibit GABAA receptor endocytosis | SIGNOR-266709 |
P52333 | P35222 | 1 | phosphorylation | up-regulates activity | 0.444 | Jak3 phosphorylates Tyr 30, Tyr 64, and Tyr 86 of beta-catenin in intestinal epithelial cells. | SIGNOR-278180 |
Q05209 | P42768 | 1 | dephosphorylation | down-regulates | 0.444 | Furthermore, we demonstrate that pstpip serves as a scaffold protein between ptp-pest and wasp and allows ptp-pest to dephosphorylate wasp. This finding suggests a possible mechanism for ptp-pest to directly modulate actin remodeling through the pstpip-wasp interaction. | SIGNOR-121136 |
Q9BYP7 | Q9UHW9 | 1 | phosphorylation | down-regulates activity | 0.444 | WNK3, which inhibits the activity of KCC3, promoted phosphorylation of Ser-96 as well as Thr-991 and Thr-1048. | SIGNOR-260912 |
Q9HC98 | P52732 | 1 | phosphorylation | up-regulates activity | 0.444 | Nek6 phosphorylated Eg5 at several sites in vitro and one of these sites, Ser1033, is phosphorylated in vivo during mitosis. Whereas CDK1 phosphorylates nearly all Eg5 at Thr926 during mitosis, Nek6 phosphorylates approximately 3% of Eg5, primarily at the spindle poles. | SIGNOR-273886 |
Q00987 | P49757 | 2 | ubiquitination | down-regulates | 0.444 | These data strongly suggest thatmdm2functions as the ubiquitin ligase toward hnumb and that it induces its degradation in intact cells. | SIGNOR-99497 |
Q8WY64 | Q14114 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.444 | Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism. Idol triggers ubiquitination of the VLDLR and ApoER2 on their cytoplasmic tails, leading to their degradation. | SIGNOR-271486 |
O15297 | Q16539 | 1 | dephosphorylation | down-regulates activity | 0.444 | Wip1 selectively inactivates p38 by specific dephosphorylation of its conserved threonine residue | SIGNOR-84793 |
Q15139 | P22059 | 1 | phosphorylation | down-regulates | 0.444 | Pkd attenuates the function of both cert and osbp by phosphorylation at their respective ser(132) and ser(240) residues (phosphorylation inhibition) | SIGNOR-171756 |
P35354 | P05112 | 1 | null | up-regulates | 0.444 | Cox2 Is a Direct Srf Target Gene and Controls Il4 Expression | SIGNOR-255967 |
P30968 | P63092 | 1 | binding | up-regulates activity | 0.444 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256792 |
P17612 | O60825 | 1 | phosphorylation | up-regulates activity | 0.444 | PFK-2 that was phosphorylated on Ser466, but not Ser483, by PKA did not bind to 14-3-3s‚ | SIGNOR-250025 |
P12931 | P15941 | 1 | phosphorylation | up-regulates | 0.444 | The c-src tyrosine kinase regulates signaling of the human df3/muc1 carcinoma-associated antigen with gsk3 beta and betBeta-catenin c-src phosphorylates the muc1 cytoplasmic domain at a yekv motif c-src-mediated phosphorylation of muc1 increases binding of muc1 and betBeta-catenin | SIGNOR-85938 |
Q99933 | O75807 | 1 | null | down-regulates activity | 0.444 | Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions.|BAG-1 negatively modulates GADD34-bound PP1 activity, and the expression of BAG-1 isoforms can also mask GADD34-mediated inhibition of colony formation and suppression of transcription. Our findings suggest tha... | SIGNOR-254117 |
P53350 | Q6IBW4 | 1 | phosphorylation | up-regulates activity | 0.444 | Plk1 phosphorylation of CAP-H2 at Ser288 is required for the accumulation of CAP-H2 and accurate chromosomal condensation during prophase. | SIGNOR-278419 |
P08311 | P05546 | 1 | cleavage | down-regulates activity | 0.444 | Amino acid sequence analysis led to the conclusion that both neutrophil elastase and cathepsin G cleave HC at Ile66, which does not affect HC activity, and at Val439, near the reactive site Leu444, which inactivates HC. | SIGNOR-256509 |
Q6N021 | O15294 | 1 | binding | up-regulates | 0.444 | Tet2 and tet3 associate with the o_glcnac transferase ogt / tet2 and tet3 promote ogt_mediated glcnacylation | SIGNOR-200695 |
P48546 | P63092 | 1 | binding | up-regulates activity | 0.444 | The GPCRs are allocated in five families where the GLP-1R and GIPR are found within the secretin family, also classified as class B [31,32]. Upon stimulation by an extracellular stimuli (ligand), GPCRs undergo conformational changes, and triggers downstream intracellular signals by coupling with G proteins (or other in... | SIGNOR-278138 |
P34969 | P38405 | 1 | binding | up-regulates activity | 0.444 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256926 |
P49757 | Q00987 | 2 | binding | down-regulates | 0.444 | Numb interacts with mdm2, and inhibits its ubiquitin-ligase function on tp53 (which in itself is inhibitory for tp53), thus numb activates (b) tp53 | SIGNOR-168454 |
O95376 | Q96P20 | 1 | ubiquitination | up-regulates activity | 0.444 | ARIH2 can ubiquitinate NLRP3 via the NACHT domain of NLRP3, and the RING2 domain of ARIH2 is required for NLRP3 ubiquitination 65.|Overexpression of ARIH2 promotes NLRP3 ubiquitination and inhibits NLRP3 inflammasome activation 65. | SIGNOR-278686 |
P53779 | Q93045 | 1 | phosphorylation | down-regulates | 0.444 | We demonstrate that purified scg10 can be phosphorylated by two subclasses of mitogen-activated protein (map) kinases, c-jun n-terminal/stress-activated protein kinase (jnk/sapk) and p38 map kinase;jnk3/sapkbeta phosphorylation occurs at ser-62 and ser-73, residues that result in reduced microtubule-destabilizing activ... | SIGNOR-112114 |
P49841 | P48436 | 1 | phosphorylation | down-regulates activity | 0.444 | (E) The SOX9 K2 domain is phosphorylated by GSK3\u03b2 at T236.|Based on our findings that inhibition of GSK3\u03b2 prevents DNA damage-induced SOX9 degradation, and that FBW7 targets SOX9 for degradation after DNA damage, we reasoned that phosphorylation of SOX9 by GSK3\u03b2 is required for FBW7-mediated SOX9 degrada... | SIGNOR-279725 |
Q8IXJ9 | P10276 | 1 | binding | up-regulates activity | 0.444 | Therefore, ASXL1, a vertebrate PcG/TrxG protein, may mediate RA-regulated cell growth by modulating RAR activity.Finally, the ASXL1-induced accumulation of acetylated H3 may enhance the RAR-mediated transcriptional activity. In this study, we demonstrate that mammalian ASXL1 interacts with the AF-2 AD core of RAR (and ... | SIGNOR-255910 |
O15297 | Q13950 | 1 | dephosphorylation | up-regulates activity | 0.444 | Activating dephosphorylation of RUNX2 by Wip1 increases its transcriptional activity on the Bax promoter. | SIGNOR-277110 |
P53350 | Q00613 | 1 | phosphorylation | down-regulates | 0.444 | Hsf1 was phosphorylated by plk1 at ser(216) of the dsgxxs motif during the timing of mitosis and a phospho-defective mutant form of hsf1 inhibited mitotic progression. Phosphorylated hsf1 during spindle pole localization underwent ubiquitin degradation through the scf(beta-trcp) pathway. | SIGNOR-180915 |
P62136 | P27361 | 1 | dephosphorylation | down-regulates | 0.444 | P-erk1/2 proteins were efficiently dephosphorylated in vitro by protein phosphatases 1 and 2a (pp1/2a) and mapk phosphatase 3 (mkp3). the dual specificity phosphatases that specifically dephosphorylate and inactivate the p-erk1/2 are called mapk phosphatases | SIGNOR-103155 |
Q9Y577 | Q07820 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.444 | Here, we identified Trim17 as a novel E3 ubiquitin-ligase for Mcl-1. Indeed, Trim17 co-immunoprecipitated with Mcl-1. Trim17 ubiquitinated Mcl-1 in vitro. Overexpression of Trim17 decreased the protein level of Mcl-1 in a phosphorylation- and proteasome-dependent manner. Finally, knock down of Trim17 expression reduced... | SIGNOR-272032 |
O14559 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.444 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260491 |
Q92630 | O14746 | 1 | phosphorylation | down-regulates activity | 0.444 | Dyrk2 phosphorylates TERT protein, a catalytic subunit of telomerase.|In this study, we found that dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (Dyrk2) negatively regulates telomerase activity. | SIGNOR-279611 |
Q00526 | P05412 | 1 | phosphorylation | up-regulates | 0.443 | Egf-induced cdk3 activation caused c-jun phosphorylation at ser63 and ser73, resulting in increased ap-1 transactivation. | SIGNOR-183013 |
Q13315 | O75150 | 1 | phosphorylation | up-regulates | 0.443 | E3 ubiquitin ligase, a heterodimeric complex of the ringfinger rfn20/rfn40 is phosphorylated by atm. | SIGNOR-175003 |
P18031 | Q16539 | 1 | dephosphorylation | down-regulates activity | 0.443 | Here, we show that PTP1B regulates CD40 and BAFF-R signaling and dephosphorylates the mitogen-activated protein kinase p38.|Specifically, PTP1B counteracts p38 mitogen-activated protein kinase activation by directly dephosphorylating Tyr182 of this kinase. | SIGNOR-277167 |
Q8TF42 | P22681 | 1 | binding | down-regulates | 0.443 | Sts-1 and sts-2 contain sh3 domains that interacted with cbl, ub-associated domains, which bound directly to mono-ub or to the egfr/ub chimera as well as phosphoglycerate mutase domains that mediated oligomerization of sts-1/2. Ligand-induced recruitment of sts-1/sts-2 into activated egfr complexes led to inhibition of... | SIGNOR-124897 |
P68400 | Q04206 | 1 | phosphorylation | up-regulates activity | 0.443 | We demonstrate that casein kinase II (CKII) interacts with p65 in vivo and can phosphorylate p65 at serine 529 in vitro. A CKII inhibitor (PD144795) inhibited TNFalpha-induced p65 phosphorylation in vivo. Furthermore, our results indicate that the association between IkappaBalpha and p65 inhibits p65 phosphorylation by... | SIGNOR-250942 |
Q00526 | P06400 | 1 | phosphorylation | down-regulates | 0.443 | The active form of prb is underphosphorylated. Cdk3/cyclin-c-mediated phosphorylation at ser-807 and ser-811 is required for g0-g1 transition. | SIGNOR-124212 |
P15976 | P23769 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.443 | GATA-2 induces the expression of GATA-1, which first activates its cofactor FOG-1, and then downregulates GATA-2 cooperatively with FOG-1. | SIGNOR-256060 |
P04637 | P35232 | 1 | binding | up-regulates activity | 0.443 | Our previous studies have shown that prohibitin physically interacts with the marked-box domain of E2F family members and represses their transcriptional activity; in contrast, prohibitin could bind to and enhance the transcriptional activity of p53. | SIGNOR-268978 |
P14618 | P40763 | 1 | phosphorylation | up-regulates activity | 0.443 | PKM2 activates transcription of MEK5 by phosphorylating stat3 at Y705. In vitro phosphorylation assays show that PKM2 is a protein kinase using PEP as a phosphate donor | SIGNOR-267716 |
O15084 | P36873 | 1 | binding | up-regulates activity | 0.443 | Phosphatase Interactor Targeting K protein (PITK) was previously identified as a novel PP1 targeting subunit implicated in modulating the phosphorylation of the transcriptional regulator heterogeneous nuclear ribonucleoprotein K (hnRNP K) | SIGNOR-264794 |
Q6ZMQ8 | Q15078 | 1 | binding | up-regulates | 0.443 | Apoptosis-associated tyrosine kinase is a cdk5 activator p35 binding protein. | SIGNOR-118403 |
Q9UKB1 | O14920 | 1 | binding | down-regulates quantity by destabilization | 0.443 | We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP. Being a part of SCF complex with Skp1 and Cullin1, HOS specifically interacted with the phosphorylated IkappaB and beta-catenin, targeting these proteins for proteasome-dependent degradation in vivo. | SIGNOR-272544 |
Q00535 | Q13224 | 1 | phosphorylation | down-regulates quantity | 0.443 | Cdk5 phosphorylates NR2B at Ser1116 and controls surface level expression.|Reduction in Cdk5 activity, as well as disruption of Cdk5-NR2B interactions consistently increased NR2B surface levels and facilitated NMDA mediated synaptic function. | SIGNOR-278265 |
O43151 | O15294 | 1 | binding | up-regulates | 0.443 | Tet2 and tet3 associate with the o_glcnac transferase ogt / tet2 and tet3 promote ogt_mediated glcnacylation | SIGNOR-200729 |
P12931 | Q13936 | 1 | phosphorylation | up-regulates activity | 0.443 | Cotransfection of human embryonic kidney (HEK)-293 cells with hCa(v)1.2b and c-Src resulted in tyrosine phosphorylation of the calcium channel, which was prevented by nitration of tyrosine residues by peroxynitrite. Whole cell calcium currents were reduced by 58 + 5% by the Src kinase inhibitor PP2 and 64 + 6% by perox... | SIGNOR-276081 |
P27361 | P36956 | 1 | phosphorylation | up-regulates activity | 0.443 | Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. | SIGNOR-80096 |
P29323 | Q13224 | 1 | phosphorylation | up-regulates quantity | 0.443 | In addition, EPHB2 signaling leads to phosphorylation of GluN2B at tyrosine residue 1472 preventing clathrin dependent endocytosis, and increasing the surface retention of GluN2B containing NMDARs. | SIGNOR-279710 |
P54646 | O60825 | 1 | phosphorylation | up-regulates activity | 0.443 | AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells. activation of PFK-2 was due to the phosphorylation of Ser466 | SIGNOR-250323 |
Q96Q27 | P21333 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.442 | ASB2 is the specificity subunit of an E3 ubiquitin ligase complex and is proposed to exert its effects by regulating the turnover of specific proteins; however, no ASB2 substrates had been identified. Here, we report that ASB2 targets the actin-binding proteins filamin A and B for proteasomal degradation. | SIGNOR-271740 |
P68400 | P08575 | 1 | phosphorylation | up-regulates | 0.442 | Mutational analysis of ck2 consensus sites showed that the target for ck2 was in an acidic insert of 19 amino acids in the d2 domain, and ser to ala mutations at amino acids 965, 968, 969, and 973 abrogated ck2 phosphorylation of cd45. Ck2 phosphorylation increased cd45 activity 3-fold toward phosphorylated myelin basi... | SIGNOR-65277 |
P06213 | P60484 | 1 | phosphorylation | down-regulates activity | 0.442 | Our results show that the kinase region of IRβ subunit physically binds to PTEN and phosphorylates on Y27 and Y174. In the current study, we discovered that IR also downregulates PTEN through tyrosine phosphorylation and suggest that Y27 and 174 are the two key tyrosines. | SIGNOR-276470 |
P62324 | P17482 | 1 | binding | up-regulates activity | 0.442 | The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. | SIGNOR-221019 |
P17252 | P19086 | 1 | phosphorylation | up-regulates | 0.442 | Functional role of amino-terminal serine16 and serine27 of g alphaz in receptor and effector coupling. | SIGNOR-48681 |
Q96BR1 | P49841 | 1 | phosphorylation | down-regulates activity | 0.442 | Phosphorylation of GSK3 by PKB or SGK1 inhibits GSK3 activity|estern blotting using an antibody specific for the PKB/SGK1 consensus phosphorylation site in GSK3a/beta (serine 21 and 9 respectively) revealed an increase in GSK3a/beta phosphorylation in human embryonic kidney 293 (HEK293) cells overexpressing wild type S... | SIGNOR-249167 |
Q8IYK4 | P02452 | 1 | glycosylation | up-regulates activity | 0.442 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261156 |
P05186 | P10451 | 1 | dephosphorylation | down-regulates activity | 0.442 | This result suggests that endogenous mouse TNAP dephosphorylates OPN in osteoblasts and that overexpressed human TNAP dephosphorylates OPN, compensating for the lack of endogenous TNAP in [Col1a1-Tnap +/\u2212 ;Alpl \u2212/\u2212 ] cells. | SIGNOR-277045 |
P68871 | Q86VB7 | 1 | binding | up-regulates activity | 0.442 | These data suggest that hemoglobin may mediate a stimulatory effect on erythropoiesis through the activation of CD163 on hematopoietic progenitor cells. | SIGNOR-251746 |
P04626 | P49327 | 1 | phosphorylation | up-regulates activity | 0.442 | Conversely, HER2 directly phosphorylates and activates FASN, while it also promotes FASN gene expression ( xref ; xref ).|Conversely, HER2 directly phosphorylates and activates FASN, while it also promotes FASN gene expression. | SIGNOR-278399 |
Q12923 | P25963 | 1 | dephosphorylation | up-regulates quantity by stabilization | 0.442 | Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1|A full-length FAP-1 protein preferentially dephosphorylates Tyr-42 of IkBa|Moreover, other studies have shown that tyrosine phosphorylation of IkBa on Tyr-42 (which occurs with Fas ligand binging) protected against inducible degradation both ... | SIGNOR-248712 |
O14965 | Q9UPY8 | 1 | phosphorylation | up-regulates | 0.442 | Aurora-a and aurora-b phosphorylate eb3 at ser-176 in a spatial and cell cycle-specific manner, respectively during mitosis two kinases, aurora-a and aurora-b, phosphorylate eb3 at ser-176, and the resulting phosphorylation disrupts the eb3-siah-1 complex. Indeed, eb3 is stabilized during mitosis and facilitates cell ... | SIGNOR-187657 |
P01148 | P18146 | 1 | binding | up-regulates activity | 0.442 | EGR1 bound to two binding sites on the LHB promoter and this binding was increased by GNRH1. Mutation of either site or knockdown of endogenous EGR1 decreased basal and/or GNRH1-regulated promoter activity. | SIGNOR-254918 |
P19419 | P17252 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.442 | The luciferase reporter assay results revealed that the presence of both MZF-1 and Elk-1 significantly contributed to the upregulation of PKCα gene transcription activity. | SIGNOR-256336 |
O15013 | P63000 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.442 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260536 |
O95071 | Q8IYW5 | 1 | ubiquitination | down-regulates quantity | 0.442 | Here, we show that TRIP12 and UBR5, two HECT domain ubiquitin E3 ligases, control accumulation of RNF168, a rate-limiting component of a pathway that ubiquitylates histones after DNA breakage. We find that RNF168 can be saturated by increasing amounts of DSBs. Depletion of TRIP12 and UBR5 allows accumulation of RNF168 ... | SIGNOR-266782 |
P54821 | P11831 | 1 | binding | up-regulates | 0.442 | The human homeodomain proteinphox1interacts functionally with serum response factor (srf) to impart serum responsive transcriptional activity to srf-binding sites in a hela cell cotransfection assay. | SIGNOR-52657 |
Q9Y6E0 | Q9Y2H1 | 1 | phosphorylation | up-regulates | 0.441 | Ndr1/ndr2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site ser281/ser282 and the hydrophobic motif phosphorylation site thr444/thr442. Autophosphorylation of ndr is responsible for phosphorylation on ser281/ser282, whereas thr444/thr442 is targeted by an upstream kinase. Here w... | SIGNOR-142510 |
O00255 | Q9BXW9 | 1 | binding | up-regulates | 0.441 | Menin interacts with fancd2 / loss of menin expression in mouse embryonic fibroblasts leads to increased sensitivity to dna damage. Furthermore, menin is localized to chromatin and nuclear matrix, and the association with nuclear matrix is enhanced by gamma-irradiation. Together, these results suggest that menin plays ... | SIGNOR-103947 |
Q14164 | Q9NQC7 | 1 | phosphorylation | down-regulates activity | 0.441 | CYLD is phosphorylated by IKK\u03b5 at Ser418.|Together, these observations demonstrate that I\u03baB kinase\u03b5-mediated phosphorylation of CYLD at Ser418 inhibits CYLD deubiquitinase activity. | SIGNOR-278311 |
P53350 | P36956 | 1 | phosphorylation | up-regulates activity | 0.441 | As illustrated in , the turnover of nuclear SREBP1a was attenuated in the presence of Plk1, confirming that Plk1 stabilizes nuclear SREBP1 by reducing its degradation.|Figure 2.Plk1 phosphorylates threonine 424, serine 467 and serine 486 in nuclear SREBP1 during mitosis. (A) In vitro kinase assay with recombinant nucle... | SIGNOR-279382 |
P28482 | P07101 | 1 | phosphorylation | up-regulates | 0.441 | Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylase in vitro at comparable rates to other proteins thought to be physiological substrates of these protein kinases.The effect on ac... | SIGNOR-34674 |
Q9UK97 | Q9Y4R8 | 1 | binding | down-regulates quantity by destabilization | 0.441 | Here we report that Tel2 and Tti1 are targeted for degradation within mTORC1 by the SCFFbxo9 ubiquitin ligase to adjust mTOR signalling to growth factor availability. The interaction between Tel2/Tti1 and Fbxo9 identified by mass spectrometry suggests that SCFFbxo9 is probably the ubiquitin ligase that mediates degrada... | SIGNOR-271996 |
P38398 | Q03468 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.441 | BRCA1 polyubiquitinates CSB and this polyubiquitination and subsequent degradation of CSB occur following UV irradiation, even in the absence of Cockayne syndrome A (CSA) protein. | SIGNOR-272754 |
P60484 | Q99801 | 1 | dephosphorylation | up-regulates quantity by stabilization | 0.441 | Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.|PTEN was also able to dephosphorylate NKX3.1 at threonine 179, a target of protein kinase C, but not threonine residues 89 and 93, targeted by casein kinase 2 . | SIGNOR-277026 |
Q9UKB1 | O15111 | 1 | binding | down-regulates quantity by destabilization | 0.441 | We identified a human F-box/WD40 repeats protein (HOS), which is homologous to Slimb/h betaTrCP. Being a part of SCF complex with Skp1 and Cullin1, HOS specifically interacted with the phosphorylated IkappaB and beta-catenin, targeting these proteins for proteasome-dependent degradation in vivo. | SIGNOR-272545 |
P05771 | P14679 | 1 | phosphorylation | up-regulates | 0.441 | We conclude that pkc-beta activates tyrosinase directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein. our results strongly suggest that direct phosphorylation of tyrosinase by pkc-_ leads to its activation. | SIGNOR-67870 |
O14519 | P24941 | 1 | binding | down-regulates activity | 0.441 | The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G1-to-S phase transition. | SIGNOR-264781 |
Q96EB6 | O15105 | 1 | deacetylation | down-regulates | 0.441 | Sirt1 reversed acetyl-transferase (p300)-mediated acetylation of two lysine residues (lys-64 and -70) on smad7. sirt1-mediated deacetylation of smad7 enhanced smad ubiquitination regulatory factor 1 (smurf1)-mediated ubiquitin proteasome degradation, which contributed to the low expression of smad7 in sirt1-overexpres... | SIGNOR-150595 |
Q03164 | P17947 | 1 | methylation | up-regulates quantity by expression | 0.441 | Furthermore, we show that both MLL and AML1/CBFβ are required for maintaining the H3K4-me3 mark at the PU.1 upstream regulatory element (URE) and promoter region, and for full PU.1 gene expression. | SIGNOR-255874 |
P17252 | Q15139 | 1 | phosphorylation | up-regulates | 0.441 | These results provide direct evidence that pkd becomes activated in vivo as a consequence of pkc-mediated phosphorylation of serines 744 and 748. | SIGNOR-66666 |
Q9UNE7 | P54253 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.441 | CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation|Interestingly, CHIP also interacts with and ubiquitinates unexpanded ataxin-1 | SIGNOR-278666 |
P19484 | P11279 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.441 | Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GU... | SIGNOR-276555 |
P24941 | P06401 | 1 | phosphorylation | down-regulates | 0.441 | Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26s proteasome | SIGNOR-74708 |
P00519 | P78352 | 1 | phosphorylation | up-regulates activity | 0.441 | Moreover, c-Abl phosphorylates PSD-95 at tyrosine 533.|c-Abl modulates the synaptic contact number and PSD-95 clustering. | SIGNOR-278391 |
P60484 | P23528 | 1 | dephosphorylation | up-regulates activity | 0.441 | Unexpectedly, cofilin-1 activation by PGE 2 was mediated by the protein phosphatase activity of PTEN (phosphatase and tensin homolog deleted on chromosome 10), with which it directly associated.|Unexpectedly, cofilin-1 dephosphorylation and activation in our model was mediated by the protein phosphatase activity of PTE... | SIGNOR-276980 |
O00253 | Q01718 | 1 | binding | down-regulates activity | 0.441 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanoc... | SIGNOR-268696 |
P00533 | O00750 | 1 | phosphorylation | up-regulates | 0.44 | The n-terminal region of pi3k-c2beta was found to selectively interact with the egf receptor in vitro, suggesting that it mediates the association of this pi3k with the receptor. | SIGNOR-77195 |
Q96CN5 | Q5TZA2 | 1 | binding | up-regulates activity | 0.44 | Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. LRRC45 interacts with C-Nap1 and rootletin | SIGNOR-273704 |
Q02156 | P17302 | 1 | phosphorylation | down-regulates activity | 0.44 | Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication.|These data strongly suggest that PKC directly phosphorylates Cx43 on S368 in vivo, which results in a change in single channel behavior that contributes to a decrease in intercellular communication. | SIGNOR-144465 |
Q9UM73 | Q92529 | 1 | phosphorylation | up-regulates | 0.44 | Anaplastic lymphoma kinase (alk), which turned out to be one of these phosphoproteins, was constitutively activated and associated with the ptb domain of shcc in three neuroblastoma cells. In vitro kinase assay revealed that shcc is a potent substrate of the activated alk kinase. The alk gene locus was significantly am... | SIGNOR-91537 |
Q9BY84 | Q9UQF2 | 1 | binding | up-regulates | 0.44 | Here we report that jip-1 also binds the dual-specificity phosphatases mkp7 and m3/6 via a region independent of its jnk binding domain. when mkp7 is bound to jip-1 it reduces jnk activation leading to reduced phosphorylation of the jnk target c-jun | SIGNOR-97173 |
O00222 | P63092 | 1 | binding | up-regulates activity | 0.44 | MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G p... | SIGNOR-264081 |
P47901 | P63092 | 1 | binding | up-regulates activity | 0.44 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256791 |
P31749 | O75030 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.44 | We found that AKT phosphorylates MITF at S510. Phosphorylated MITF S510 enhances its affinity to TP53 and promotes CDKN1A expression. Phosphorylation of MITF by AKT induces its degradation | SIGNOR-277281 |
O00253 | Q01726 | 1 | binding | down-regulates activity | 0.44 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268699 |
O43353 | O14733 | 1 | phosphorylation | up-regulates activity | 0.44 | Collectively, the results suggest that RIPK2 binds to and activates MKK7.|Radioactive in vitro kinase assay showed that RIPK2 can directly phosphorylate kinase-dead (K149A) MKK7 (Fig.\u00a0 xref ). | SIGNOR-280105 |
O15294 | Q8NFU7 | 1 | glycosylation | up-regulates activity | 0.44 | The DNA demethylation enzyme Tet1 interacts with Ogt and is O-GlcNAcylated. Tet1 protein stability is positively regulated by O-GlcNAcylation, and its repression function on targeting genes is dependent on Ogt. | SIGNOR-259184 |
P53701 | P99999 | 1 | chemical modification | up-regulates activity | 0.44 | Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in which four electrons, four protons, and one molecule of oxygen are consumed. The reaction is coupled to the pumping of four additional protons across the membrane. According to the currently accepted concept, the pumping of all four... | SIGNOR-280296 |
P53350 | Q76N32 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.44 | We show that the intercentrosomal linker protein Cep68 is degraded in prometaphase through the SCF(βTrCP) (Skp1-Cul1-F-box protein) ubiquitin ligase complex. Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP. | SIGNOR-275621 |
Q00535 | P56817 | 1 | phosphorylation | up-regulates activity | 0.44 | BACE1 is phosphorylated by p25 and Cdk5 at Thr252.|Our finding that p25/Cdk5 stimulates BACE1 activity supports that p25/Cdk5 may represent a promising target for the development of drugs to treat Alzheimer's disease. | SIGNOR-278249 |
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