IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P15173 | P23409 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.433 | [...] confirming that myogenin binds to the E1 and E2 E boxes located in close proximity to the MRF4 transcription start site. | SIGNOR-255642 |
Q8TAP6 | P53350 | 1 | binding | down-regulates activity | 0.433 | Here, we found that centrosomal protein of 76 kDa (Cep76), previously shown to restrain centriole amplification, interacts with cyclin-dependent kinase 2 (CDK2) and is a bona fide substrate of this kinase. Cep76 is preferentially phosphorylated by cyclin A/CDK2 at a single site S83, and this event is crucial to suppres... | SIGNOR-262731 |
Q12933 | Q8IUC6 | 1 | polyubiquitination | up-regulates | 0.433 | Here, we show that the TRAF family proteins directly bind TICAM-1 and demonstrate that TRAF2 and TRAF6 bind different sites of the N-terminal TICAM-1 and accelerate its polyubiquitination. we speculate that polyubiquitination of TICAM-1 by TRAF2 and TRAF6 is required for TICAM-1 to induce IRF-3 and NF-κB activation. Th... | SIGNOR-271427 |
Q92905 | Q13485 | 1 | ubiquitination | down-regulates | 0.433 | We report a novel mechanism of smad4 degradation. Jab1 interacts directly with smad4 and induces its ubiquitylation for degradation | SIGNOR-114697 |
Q7Z3K3 | P45973 | 1 | binding | down-regulates activity | 0.433 | POGZ was found to bind to HP1alpha through a zinc-finger-like motif. Binding by POGZ, mediated through its zinc-finger-like motif, competed with PxVxL proteins and destabilized the HP1alpha-chromatin interaction. | SIGNOR-264487 |
P21452 | O95837 | 1 | binding | up-regulates activity | 0.433 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257131 |
Q9UBR4 | Q96A47 | 1 | binding | up-regulates activity | 0.433 | a direct NLI-independent interaction between Lhx3 and the related proteins Isl1 and Isl2 was observed. The combinatorial expression of the LIM homeodomain proteins Isl1, Isl2, Lhx1, and Lhx3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct... | SIGNOR-236836 |
Q9C004 | P04049 | 1 | binding | down-regulates activity | 0.433 | Here we show that mammalian Sprouty4 suppresses vascular epithelial growth factor (VEGF)-induced, Ras-independent activation of Raf1 but does not affect epidermal growth factor (EGF)-induced, Ras-dependent activation of Raf1. Sprouty4 binds to Raf1 through its carboxy-terminal cysteine-rich domain, and this binding is ... | SIGNOR-253033 |
P17655 | P10636 | 1 | cleavage | down-regulates activity | 0.433 | Besides tau phosphorylation, calpain activation might play a role in tau-mediated neurodegeneration by inducing tau cleavage. In vitro studies have shown that both fetal and adult tau isoforms are rapidly proteolyzed by calpains | SIGNOR-251611 |
P07949 | P27361 | 1 | phosphorylation | up-regulates | 0.433 | We hypothesized that ret could directly phosphorylate fak and erk. erk 2 could be phosphorylated at y187 (y204 in erk1). | SIGNOR-140298 |
O00141 | P48764 | 1 | phosphorylation | up-regulates activity | 0.433 | The NHE3 activation by SGK1 is dependent on their combined interaction with NHERF2 and then phosphorylation at S663 of NHE3 by SGK1 ( xref , xref ). | SIGNOR-279112 |
Q9H4P4 | Q8N1B4 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.433 | RNF41 ubiquitinates and relocates VPS52 away from VPS53, another shared subunit of the GARP and EARP complexes, towards RNF41-positive structures. | SIGNOR-278597 |
Q04206 | P18146 | 1 | binding | up-regulates | 0.433 | The early growth response transcription factor egr-1 can also interact with rela in vitro and regulate nf-kappab transcriptional activity in vivo | SIGNOR-75001 |
Q06187 | Q13422 | 1 | phosphorylation | up-regulates activity | 0.432 | We demonstrate that BTK phosphorylates Ikaros at unique phosphorylation sites S214 and S215 in the close vicinity of its zinc finger 4 (ZF4) within the DNA binding domain, thereby augmenting its nuclear localization and sequence-specific DNA binding activity. | SIGNOR-279442 |
Q13627 | Q13247 | 1 | phosphorylation | up-regulates activity | 0.432 | These results suggest that Dyrk1A enhances SRp55 promoted cTnT exon 5 inclusion.|These results supported the finding that phosphorylation of SRp55 by Dyrk1A promotes cTnT exon 5 inclusion.Alternative splicing of cTnT exon 5 is regulated developmentally. | SIGNOR-279166 |
P54829 | Q12879 | 1 | dephosphorylation | down-regulates activity | 0.432 | STEP inhibition by TC-2153 enhanced Tyr phosphorylation of GluN2A (XREF_FIG, 1 EGTA+TC-2153, n = 5, P < 0.05 compared with 1mM EGTA) without altering phosphorylation of Src (XREF_FIG, 1 EGTA+TC-2153, n = 5, P> 0.05 compared with 1 EGTA).|These findings confirm that not only GluN2B and Fyn but also GluN2A are substrates... | SIGNOR-277089 |
P63211 | P42336 | 1 | binding | up-regulates | 0.432 | Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt | SIGNOR-154261 |
P17612 | Q9Y698 | 1 | phosphorylation | down-regulates activity | 0.432 | phosphorylation of stargazin at T321 by PKA inhibits its interaction with PSD-95. | SIGNOR-250342 |
Q9Y2Y9 | Q96ST3 | 1 | binding | up-regulates activity | 0.432 | detailed biochemical and functional analyses have demonstrated that the TIEG2 _-HRM domain interacts specifically with the PAH2 domain of mSin3A to repress transcription. our data suggest the presence of a conserved _-helical repression motif (_-HRM) in the TIEG and BTEB subfamilies of Sp1-like proteins that mediates t... | SIGNOR-222437 |
Q00987 | Q02878 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.432 | Furthermore, we also demonstrated that RPL6 is a substrate for HDM2-mediated ubiquitination and proteasomal degradation.|The interaction of RPL6 and HDM2 drives HDM2 mediated RPL6 polyubiquitination and proteasomal degradation. | SIGNOR-278630 |
Q13315 | Q16665 | 1 | phosphorylation | up-regulates | 0.432 | Here we show that hypoxia results in ataxia telangiectasia mutated (atm)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (hif-1_) on serine(696) and mediates downregulation of mtorc1 signaling. phosphorylation of hif-1_ by atm is required for its stability | SIGNOR-169999 |
P17612 | P46020 | 1 | phosphorylation | up-regulates activity | 0.432 | Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. | SIGNOR-267411 |
P49137 | Q14457 | 1 | phosphorylation | up-regulates activity | 0.432 | Beclin 1 S90 is phosphorylated by MAPKAPK2 (MK2) and MAPKAPK3 (MK3). | SIGNOR-278342 |
Q14669 | Q13564 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.432 | Our data suggest that that TRIP12 promotes degradation of APP-BP1 by catalyzing its ubiquitination, which in turn modulates the neddylation pathway. | SIGNOR-266780 |
Q9UNY4 | Q99459 | 1 | binding | up-regulates quantity by stabilization | 0.432 | HLodestar/HuF2 associates with CDC5L in cell lysates and HeLa nuclear extracts. It is possible that during the cell division cycle, hLodestar/HuF2s associates with transcription/splicing complexes in order to inhibit transcription/splicing prior to the start of mitosis and/or functions in stabilizing nuclear complexes... | SIGNOR-224460 |
P28482 | P33076 | 1 | phosphorylation | up-regulates | 0.432 | We show in this study that the nuclear localized form of ciita is a predominantly phosphorylated form of the protein, whereas cytoplasmic ciita is predominantly unphosphorylated. Novel phosphorylation sites were determined to be located within a region that contains serine residues 286, 288, and 293. Double mutations o... | SIGNOR-160609 |
P23467 | P27361 | 1 | dephosphorylation | up-regulates | 0.432 | When cells are stimulated with various ligands such as growth factors, hormones, neurotransmitters, or tumor promoters, erk1/2 is activated through dualphosphorylation at the -ptepy-motif. Subsequently, p-erk1/2 translocates into the nucleus and phosphorylates elk-1, thereby acting as a transcription factor for cell pr... | SIGNOR-103165 |
Q15025 | Q13114 | 1 | binding | down-regulates activity | 0.432 | ABIN1 interacted with the A20 regulatory molecule TAX1BP1 and was essential for the recruitment of TAX1BP1 and A20 to the noncanonical IkappaB kinases TBK1 and IKKi in response to poly(I:C) transfection. ABIN1 and TAX1BP1 together disrupted the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKKi to attenua... | SIGNOR-275736 |
O14757 | Q7Z2Z1 | 1 | phosphorylation | down-regulates activity | 0.432 | In principle, phosphorylation of Treslin by Chk1 may alter its conformation or directly affect its interactions with other proteins to preclude helicase activation.|The fact that the TRCT domain blocks the binding of Chk1 to Treslin suggests that Chk1 suppresses the initiating function of Treslin. | SIGNOR-278924 |
O00311 | Q5FWF5 | 1 | phosphorylation | down-regulates | 0.432 | We show here that eco1 degradation requires the sequential actions of cdk1 and two additional kinases, cdc7-dbf4 and the gsk-3 homolog mck1. | SIGNOR-200397 |
P67775 | O96017 | 1 | dephosphorylation | up-regulates activity | 0.432 | Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells|In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. | SIGNOR-248617 |
P10276 | P10827 | 2 | binding | up-regulates | 0.432 | We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. | SIGNOR-133231 |
P10827 | P10276 | 2 | binding | up-regulates | 0.432 | We report that the retinoic acid receptors (rars), a distinct class of nuclear receptors, are also efficient heterodimer partners for trs. | SIGNOR-133240 |
Q9H1H9 | Q6DKK2 | 1 | binding | up-regulates activity | 0.432 | We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. On t... | SIGNOR-265540 |
Q9H9S0 | P26358 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.432 | Oct4 and Nanog upregulate Dnmt1 through direct binding to its promoter, thereby leading to the repressed expression of p16 and p21 and genes associated with development and lineage differentiation | SIGNOR-253157 |
Q05655 | Q9H257 | 1 | phosphorylation | up-regulates activity | 0.432 | Here we demonstrated that protein kinase C-delta (PKCdelta) was activated upon Dectin-1-Syk signaling, mediated phosphorylation of Card9 at Thr231, and was responsible for Card9 and Bcl10 complex assembly and canonical NF-kappaB control. | SIGNOR-278383 |
P43378 | P40763 | 1 | dephosphorylation | down-regulates activity | 0.432 | Results are presented as mean \u00b1 SD from three independent experiments. (B) PTPMeg2 inhibits STAT3-mediated transcriptional activity in a dose dependent manner.|These results indicate that PTPMeg2 inhibits STAT3 activation with certain specificity.|In this study, we demonstrated that PTPMeg2 dephosphorylates STAT3 ... | SIGNOR-276976 |
Q5TG30 | P61586 | 1 | gtpase-activating protein | down-regulates activity | 0.432 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260496 |
Q93009 | Q96EP1 | 1 | deubiquitination | up-regulates quantity by stabilization | 0.432 | In this study, we identified USP7 (also known as HAUSP), which is a member of a family of proteins that cleave polyubiquitin chains and/or ubiquitin precursors, as an interacting protein with Chfr by immunoaffinity purification and mass spectrometry, and their interaction greatly increases the stability of Chfr. In fac... | SIGNOR-271462 |
Q13651 | O60674 | 1 | phosphorylation | up-regulates activity | 0.432 | IL10R2 recruits cytoplasmic protein Jak1 followed by phosphorylation of tyrosine at position 705 in the STAT3 (705Y-STAT3) molecule. Phosphorylated STAT3 forms a homodimer, which is then translocated to the nucleus to facilitate transcriptional regulation of target genes. | SIGNOR-249545 |
Q9Y252 | P53667 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.432 | Consistent with a role in axonal growth, we found that Rnf6 binds to, polyubiquitinates, and targets LIMK1 for proteasomal degradation in growth cones of primary hippocampal neurons. | SIGNOR-271481 |
O43255 | P55036 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.432 | S5a/Rpn10 is a ubiquitin (Ub)-binding protein that is a subunit of the 26S proteasome but also exists free in the cytosol. It binds poly-Ub chains through its two Ub-interacting motifs (UIMs). We discovered that, unlike typical substrates of Ub ligases (E3s), S5a can be ubiquitinated by all E3s tested including multime... | SIGNOR-272748 |
Q9GZU7 | P24928 | 1 | dephosphorylation | up-regulates activity | 0.431 | Phosphorylation and dephosphorylation of the C-terminal domain (CTD) of RNA polymerase II (Pol II) represent a critical regulatory checkpoint for transcription. Transcription initiation requires Fcp1/Scp1-mediated dephosphorylation of phospho-CTD. | This combined structure-function analysis discloses the residues in Sc... | SIGNOR-248785 |
P49841 | Q9BPU6 | 1 | phosphorylation | up-regulates activity | 0.431 | The T516 phosphorylation was achieved by the glycogen synthase kinase-3beta (GSK-3beta), which can phosphorylate the wildtype protein but not the non-phosphorylatable mutant. Furthermore, we have shown that T516 phosphorylation is essential for the tubulin-binding property of CRMP5. Therefore, CRMP5-induced growth inhi... | SIGNOR-264835 |
Q96GD4 | Q13315 | 1 | phosphorylation | up-regulates | 0.431 | Aurora-b mediated atm serine 1403 phosphorylation is required for mitotic atm activation and the spindle checkpoint | SIGNOR-177280 |
Q9UHC7 | P04637 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.431 | Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-dependent degradation. A... | SIGNOR-271846 |
Q99873 | Q92804 | 1 | methylation | up-regulates | 0.431 | The methylation of taf15 by prmt1 is required for the ability of taf15 to positively regulate the expression of the studied endogenous taf15-target genes. | SIGNOR-183137 |
Q96K19 | Q14643 | 1 | polyubiquitination | down-regulates activity | 0.431 | In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. | SIGNOR-271913 |
P49841 | Q9Y6K9 | 1 | phosphorylation | down-regulates quantity | 0.431 | For analysis of phosphorylation of NEMO on Ser8 and Ser17 by GSK-3, we generated phospho-specific antibodies (anti-phospho-NEMO-Ser8 and anti-phospho-NEMO-Ser17) while anti-phospho-NEMO-Ser31 and anti-phospho-NEMO-Ser43 were commercially available. Indeed, GSK-3\u03b2 was able to phosphorylate all four serines of rhNEM... | SIGNOR-279527 |
O14757 | Q9UKI8 | 1 | phosphorylation | down-regulates | 0.431 | Chk1 phosphorylates tlk1 on serine 695 (s695) these findings identify an unprecedented functional co- operation between atm and chk1 in propagation of a checkpoint response during s phase and suggest that, through transient inhibition of tlk kinases, the atm_chk1_tlk pathway may regulate processes involved in chromatin... | SIGNOR-99653 |
O15297 | O15151 | 1 | dephosphorylation | up-regulates quantity by stabilization | 0.431 | PPM1D also inhibits p53 activity by dephosphorylating Ser395 and stabilizing MDM2 and by dephosphorylating Ser403 on MDMX | SIGNOR-275491 |
P06493 | Q9BXS6 | 1 | phosphorylation | down-regulates | 0.431 | We report here that cdk1 phosphorylates nusap at threonine 300 and 338 in early mitosis. Phosphorylation of nusap inhibits its microtubule-binding activity in vitro and in vivo. | SIGNOR-177549 |
P32249 | P08754 | 1 | binding | up-regulates activity | 0.431 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256858 |
P0DMV8 | O14727 | 1 | binding | down-regulates | 0.431 | Here we show that the documented anti-apoptotic effect of the principal heat-shock protein, hsp70, is mediated through its direct association with the caspase-recruitment domain (card) of apaf-1 and through apoptosome formation | SIGNOR-80451 |
Q06413 | Q9UKX2 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.431 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238718 |
P51817 | O43541 | 1 | phosphorylation | up-regulates activity | 0.431 | In vitro phosphorylation assays demonstrated that PrKX phosphorylates Smad6 at a serine residue. | SIGNOR-279270 |
Q86YT6 | Q9UPN4 | 1 | ubiquitination | down-regulates | 0.43 | We demonstrate that the E3 ubiquitin ligase MIB1 is a new component of centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1 and suppresses primary cilium formation. Whereas these proteins are degraded prior to the ciliation process, MIB1 appears to maintain its targets in a latent state through ... | SIGNOR-272876 |
P07948 | P31994 | 1 | phosphorylation | up-regulates activity | 0.43 | Therefore, we conclude that FcgammaRIIb1 phosphorylation upon BCR-FcgammaR coligation is most likely due to BCR-associated Lyn | SIGNOR-249380 |
P31749 | Q05397 | 1 | phosphorylation | up-regulates activity | 0.43 | In mouse embryonic fibroblasts, AKT1 phosphorylates S695 and T700 on FAK ( xref ) and in human colon cancer cells AKT1 phosphorylates S517, S601, and S695 on FAK ( xref , xref ).|This suggests that further activation of FAK by AKT1 ( beyond that of Pten loss alone ) is required to promote FA turnover , increase tumor i... | SIGNOR-279777 |
P17612 | Q08289 | 1 | phosphorylation | up-regulates activity | 0.43 | Voltage-dependent L-type calcium (Ca) channels are heteromultimeric proteins that are regulated through phosphorylation by cAMP-dependent protein kinase (PKA) Mutagenesis of a single residue at Ser459 resulted in the loss of one site of phosphorylation by PKA, and mutagenesis of two residues at Ser478/479 resulted in t... | SIGNOR-250341 |
O00635 | Q9Y4K3 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.43 | As an E3 ligase, TRIM38 bound to TRAF6 and promoted K48-linked polyubiquitination, which led to the proteasomal degradation of TRAF6. | SIGNOR-272009 |
P26045 | P10912 | 1 | dephosphorylation | down-regulates activity | 0.43 | PTPH1 only bound Tyr534, whereas PTP1B and TC-PTP bound multiple phosphopeptides. Earlier work suggests that Tyr332, Tyr487, Tyr534, Tyr566, and Tyr627 are all phosphorylated after GH stimulation (21). Apart from Tyr627, all of these also appear good PTP substrates | SIGNOR-248459 |
P12931 | P67775 | 2 | phosphorylation | down-regulates | 0.43 | We found that ?-Syn gene overexpression in sk-n-sh cells and primary neurons led to pp2a/c phosphorylation at y307, a known target of src kinase, and consequent phosphatase inhibition. | SIGNOR-202192 |
P30559 | P63092 | 1 | binding | up-regulates activity | 0.43 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256793 |
Q16671 | O00238 | 1 | binding | up-regulates | 0.43 | See table2 | SIGNOR-121596 |
P01106 | P11166 | 1 | transcriptional regulation | up-regulates quantity | 0.43 | C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis throu... | SIGNOR-259987 |
P78527 | Q14653 | 1 | phosphorylation | up-regulates | 0.43 | Phosphorylation of irf-3 by dna-pk after virus infection results in its nuclear retention and delayed proteolysis | SIGNOR-115331 |
Q9UHC7 | P60484 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.43 | EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase.|In fact, epidermal growth factor-stimulated pAKT phosphorylates and subsequently stabilizes MKRN1, which then ubiquitinates and induces the degradation of PTEN. | SIGNOR-278830 |
P08246 | P25116 | 1 | cleavage | up-regulates activity | 0.43 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263565 |
P67775 | P12931 | 2 | dephosphorylation | down-regulates activity | 0.43 | We show that PR55gamma binds c-SRC and modulates the phosphorylation of serine 12 of c-SRC, a residue we demonstrate to be required for JNK activation by c-SRC | SIGNOR-247970 |
P33981 | Q02224 | 1 | phosphorylation | up-regulates activity | 0.43 | Strikingly, phosphorylation of Cenp-E C tail by wild-type (WT) MPS1 or CDK1-cyclin B completely reverses its inhibitory effect toward Cenp-E motor ATPase in solution. | SIGNOR-278999 |
Q15418 | Q16821 | 1 | phosphorylation | up-regulates activity | 0.43 | The protein G(M), which targets protein phosphatase 1 (PP1) to the glycogen particles and sarcoplasmic reticulum (SR) of striated muscles, is known to be phosphorylated at Ser48 and Ser67 in vitro by adenosine 3',5' cyclic monophosphate-dependent protein kinase (PKA) and at Ser48 by MAP kinase-activated protein kinase-... | SIGNOR-249036 |
Q9C040 | P07196 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.43 | Here, we show that TRIM RING finger protein TRIM2, highly expressed in the nervous system, is an UbcH5a-dependent ubiquitin ligase. We further demonstrate that TRIM2 binds to neurofilament light subunit (NF-L) and regulates NF-L ubiquitination. | SIGNOR-271776 |
Q9P227 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.43 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260480 |
Q16539 | O60381 | 1 | phosphorylation | up-regulates | 0.43 | A mutation of the p38 map kinase phosphorylation site at aa 401 [(s-a)401hbp1] also triggered hbp1 protein instability. While protein stability was compromised by mutation, the specific activities of (s-a)401hbp1 and of wild-type hbp1 appeared comparable for transcriptional repression. | SIGNOR-119138 |
Q96KB5 | P05412 | 1 | phosphorylation | up-regulates activity | 0.43 | TOPK promotes lung cancer resistance to EGFR tyrosine kinase inhibitors by phosphorylating and activating c-Jun.|These data confirm the phosphorylation of c-Jun by TOPK at serine 63 and 73 during the development of resistance to EGFR-targeted TKIs. | SIGNOR-278156 |
P30530 | P00533 | 2 | phosphorylation | up-regulates activity | 0.43 | AXL trans-actives EGFR in a ligand independent manner and induces phosphorylation of EGFR on tyrosine 1173.|In our models AXL seems to induce a re-wiring of the EGFR signaling towards the PLCgamma-PKC axis by receptor phosphorylation at tyrosine 1173. | SIGNOR-279141 |
Q13332 | P00533 | 1 | dephosphorylation | down-regulates activity | 0.43 | Similarly, Pestana et al. (89) have reported that overexpression of RPTPsigma in human A431 carcinoma cells partially inhibits EGFR activation, whereas antisense mediated suppression of RPTPsigma expression enhances EGFR activation, substrate phosphorylation, and signalling.|These data indicate that LAR and RPTPsigma m... | SIGNOR-277145 |
Q9UBC7 | O43603 | 1 | binding | up-regulates | 0.43 | Galp is therefore an endogenous ligand that preferentially binds the galr2 receptor | SIGNOR-73143 |
P23769 | O00321 | 1 | binding | up-regulates activity | 0.43 | Transcriptional assays with the Spi1 promoter-reporter demonstrated that Gata2 cooperates with Etv2 and augments the transcriptional activity of Etv2.The protein-protein interaction between Etv2 and Gata2 is mediated by the Ets and Gata domains. Using the embryoid body differentiation system, we demonstrate that co-exp... | SIGNOR-256008 |
P00533 | P30530 | 2 | phosphorylation | up-regulates activity | 0.43 | In this study, we have identified for the first time a direct interaction between EGFR and Axl RTKs, with EGF and EGFR induced activation of Axl as a novel signalling pathway to invasion in cancer cells.|The activation of Axl was shown to occur through direct phosphorylation by EGFR of Axl tyrosine 779, one of the key ... | SIGNOR-279734 |
P31749 | O14757 | 1 | phosphorylation | down-regulates | 0.43 | The chk1 protein phosphorylated by pkb on serine 280 does not enter into protein complexes after replication arrest. Moreover, chk1 phosphorylated by pkb fails to undergo activating phosphorylation on serine 345 by atm/atr. Phosphorylation by atm/atr and association with other checkpoint proteins are essential steps in... | SIGNOR-124365 |
O94901 | P49790 | 1 | binding | up-regulates activity | 0.43 | The NXF1:NXT1 complex and NUP153 interact with the amino terminus of SUN1 |In analogy to a proposal made by Chang et al.4, Nesprins could help anchoring SUN1 near the NPC to enable it to fulfill its task in mRNA export. | SIGNOR-263294 |
Q9Y6Y1 | P01160 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.429 | CAMTA1 itself stimulates the expression of the anti-proliferative peptide NPPA. | SIGNOR-261570 |
P49840 | P10636 | 1 | phosphorylation | down-regulates | 0.429 | Tau is phosphorylated by gsk-3 at several sites found in alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by a-kinase. | SIGNOR-60651 |
O60603 | Q86XR7 | 1 | binding | up-regulates activity | 0.429 | To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TL... | SIGNOR-266747 |
Q9UQM7 | Q96PV0 | 1 | phosphorylation | up-regulates activity | 0.429 | Here we show that phosphorylation of synGAP by Ca(2+)/calmodulin-dependent protein kinase II increases its Ras GTPase-activating activity by 70-95%. The Major Phosphorylation Sites, Serines 764/765, 1058, and 1123, All Contribute to Regulation of GAP Activity of synGAP by CaMKII | SIGNOR-262687 |
P53350 | Q9BVS4 | 1 | phosphorylation | up-regulates activity | 0.429 | Here, we report that the atypical protein kinase Rio2 is a novel substrate of Plk1 and can be phosphorylated by Plk1 at Ser-335, Ser-380, and Ser-548. Overexpression of Rio2 causes a prolonged mitotic exit whereas knockdown of Rio2 accelerates mitotic progression, suggesting that Rio2 is required for the proper mitotic... | SIGNOR-262937 |
Q96RI0 | O95837 | 1 | binding | up-regulates activity | 0.429 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257419 |
O15111 | P20749 | 1 | phosphorylation | up-regulates activity | 0.429 | Here we show that Akt, Erk2, and IKK1/2 phosphorylate Bcl3. Phosphorylation of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3. Phosphorylation by Erk2 and IKK1/2 of Ser114 and Ser446 converts Bcl3 into a transcriptional coregul... | SIGNOR-277362 |
P68400 | Q01892 | 1 | phosphorylation | down-regulates | 0.429 | Serine residues 37 in the transactivation domain and 129, 144 and 146 in the pest domain of spi-b are phosphorylated by ckii in vitro. The ckii phosphorylation sites mapped in vitro are phosphorylated in vivo. Mutations of the ckii phosphorylation sites increase the ability of spi-b to transactivate. Spi-b phosphorylat... | SIGNOR-73891 |
P22694 | Q92934 | 1 | phosphorylation | down-regulates | 0.429 | Ser-155 is the major phosphoacceptor site for pka on bad, but that pka also phosphorylates ser-112 and ser-136. | SIGNOR-81141 |
Q9P0L2 | P10636 | 1 | phosphorylation | down-regulates activity | 0.429 | We have studied the relationship between the phosphorylation of tau by several kinases (MARK, PKA, MAPK, GSK3) and its assembly into PHFs. MARK and PKA phosphorylate several sites within the repeats (notably the KXGS motifs including Ser262, Ser324, and Ser356, plus Ser320). This type of phosphorylation strongly reduce... | SIGNOR-250173 |
Q8NBJ5 | P08123 | 1 | glycosylation | up-regulates activity | 0.429 | Recombinant GLT25D1 and GLT25D2 enzymes showed a strong galactosyltransferase activity toward various types of collagen and toward the serum mannose-binding lectin MBL, which contains a collagen domain. Amino acid analysis of the products of GLT25D1 and GLT25D2 reactions confirmed the transfer of galactose to hydroxyly... | SIGNOR-261153 |
Q9BXM7 | Q9UJA2 | 1 | phosphorylation | down-regulates quantity | 0.429 | In vitro kinase assays using recombinant proteins under various control conditions indicated that PINK1 directly phosphorylates CLS1 (XREF_FIG).|Similar to Fbxo15, knockdown of PINK1 kinase using shRNA increased CLS1 levels, whereas overexpression of PINK1 plasmid decreased CLS1 levels . | SIGNOR-280065 |
O15105 | P62136 | 1 | binding | up-regulates | 0.429 | Smad7, induced by alk1 activation, recruits pp1? To alk1 and thereby inhibits tgf-?/Alk1-induced smad1/5 phosphorylation in ecs | SIGNOR-145389 |
Q99835 | P04899 | 1 | binding | up-regulates activity | 0.429 | it was proposed that Smo might signal through activation of Gi proteins to reduce PKA activity. | SIGNOR-199162 |
P31751 | Q15365 | 1 | phosphorylation | down-regulates activity | 0.429 | We show that heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) binds a structural, 33-nucleotide TGF-beta-activated translation (BAT) element in the 3' untranslated region of disabled-2 (Dab2) and interleukin-like EMT inducer (ILEI) transcripts, and represses their translation.TGF-beta activation leads to phosphory... | SIGNOR-262625 |
P06493 | P55211 | 1 | phosphorylation | down-regulates | 0.429 | Here, we show that the apoptotic initiator protease caspase-9 is regulated during the cell cycle through periodic phosphorylation at an inhibitory site, thr125. This site is phosphorylated by cdk1/cyclin b1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle. | SIGNOR-141621 |
Q99986 | Q96GD4 | 1 | phosphorylation | up-regulates activity | 0.429 | In the VRK1 overexpression of experiment, VRK1 caused a significant stabilization of AURKB, with no change in level after 24h, which is consistent with protection of AURKB against its known degradation by ubiquitylation .|The phosphorylation of AURKB by VRK1 and VRK1 by AURKB was tested using a kinase-dead form as subs... | SIGNOR-280160 |
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