IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P27361 | P46527 | 1 | phosphorylation | down-regulates | 0.376 | These data suggest that increased signaling by erbb receptors up-regulates mapk activity, which, in turn, phosphorylates and destabilizes p27, thus contributing to dysregulated cell cycle progression. | SIGNOR-80234 |
P07384 | P25116 | 1 | cleavage | up-regulates activity | 0.376 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263559 |
Q16827 | P40763 | 1 | dephosphorylation | down-regulates activity | 0.376 | In addition, this group found that PTPRO dephosphorylated STAT3 at Y705 and S727 then attenuated STAT3 signalling. | SIGNOR-277062 |
Q7Z6J0 | Q12852 | 1 | binding | up-regulates | 0.376 | One explanation as provided by our model is that mlk3 and dlk interact indirectly via posh with mutual activation when both are wild-type the multidomain protein posh binds to the constitutively active form of rac1, which is known to regulate the activity of mlks, while jip1 binds to mlks and additional components of ... | SIGNOR-108577 |
P06400 | P17480 | 1 | binding | down-regulates activity | 0.376 | Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product | SIGNOR-262589 |
P45983 | P54259 | 1 | phosphorylation | down-regulates activity | 0.376 | Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-jun nh2-terminal kinase. serine 734 of the drpla protein is a phospho-acceptor site by jnk. The phosphorylation may be coupled to the activation of a protease. The molecular size of drpla protein detected in the rat brain with the specific phosphopepti... | SIGNOR-102398 |
Q5S007 | O43353 | 1 | phosphorylation | up-regulates activity | 0.376 | Altogether, our results indicate a scenario that LRRK2 physically interacts with Rip2 and promotes phosphorylation of Rip2.|Taken together, our results show that LRRK2 enhances Rip2 activity by promoting the phosphorylation of Rip2 at Ser176. | SIGNOR-278953 |
P49841 | Q07812 | 1 | phosphorylation | up-regulates | 0.376 | Glycogen synthase kinase-3beta phosphorylates bax and promotes its mitochondrial localization during neuronal apoptosis. Gsk-3beta directly phosphorylated bax(alpha) on ser163 | SIGNOR-130141 |
Q05923 | Q16659 | 1 | dephosphorylation | down-regulates activity | 0.376 | DUSP2 can dephosphorylate both ERK3 and ERK4 when expressed in mammalian cells.|Finally, we demonstrate that DUSP2 inhibits ERK3 and ERK4 mediated activation of MK5. | SIGNOR-277069 |
Q0VAM2 | P01112 | 1 | binding | up-regulates | 0.376 | Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. | SIGNOR-183832 |
P19784 | Q9UD71 | 1 | phosphorylation | up-regulates activity | 0.375 | Study of [Plphosphate release during manual Edman degradation confirmed that the phosphorylated residues in rat DARPP-32 were Ser45 and Ser102. | Phosphorylation by casein kinase II did not affect the potency of DARPP-32 as an inhibitor of protein phosphatase-1, which depended only on phosphorylation of Thr34 by cAMP-... | SIGNOR-251018 |
Q9NZP8 | P00738 | 1 | cleavage | up-regulates activity | 0.375 | We demonstrate that coexpression of the proform of Hp (proHp) and C1r-LP in COS-1 cells effected cleavage of proHp in the endoplasmic reticulum. This cleavage depended on proteolytic activity of C1r-LP because mutation of the putative active-site Ser residue abolished the reaction. Furthermore, incubation of affinity-p... | SIGNOR-256358 |
P45983 | P05787 | 1 | phosphorylation | up-regulates | 0.375 | Kinase assays showed that c-jun n-terminal kinase (jnk) was also activated with activation kinetics corresponding to that of k8 phosphorylation. Furthermore, k8 was also phosphorylated on ser-73 by jnk in vitro. The ser-73 --> ala-associated filament reorganization defect is rescued by a ser-73 --> asp mutation. Also, ... | SIGNOR-113645 |
P49137 | O95453 | 1 | phosphorylation | down-regulates | 0.375 | Mk2 phosphorylates parn, blocking gadd45_ mrna degradation. Parn can serve as a direct substrate for mk2, and demonstrating that ser-557 is the dominant mk2 phosphorylation site. | SIGNOR-168377 |
P54764 | P51692 | 1 | phosphorylation | up-regulates activity | 0.375 | We have shown here that EphA4 can phosphorylate STAT5B, but it is not yet clear whether the nuclear translocation of phosphorylated STAT5B is enhanced by EphA4. | SIGNOR-278934 |
P25021 | P38405 | 1 | binding | up-regulates activity | 0.375 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256920 |
P78527 | Q00839 | 1 | phosphorylation | up-regulates | 0.375 | We identify heterogeneous nuclear ribonucleoprotein u (hnrnp-u), also termed scaffold attachment factor a (saf-a), as a specific substrate for dna-pk. We show that hnrnp-u is phosphorylated at ser59 by dna-pk in vitro and in cells in response to dna double-strand breaks | SIGNOR-185058 |
Q8N5U6 | P50222 | 1 | binding | up-regulates activity | 0.375 | RFN10 co-immunoprecipitates with MEOX2. RNF10 potentiates MEOX2 transcriptional activation | SIGNOR-236968 |
P28358 | O00470 | 1 | binding | up-regulates activity | 0.375 | We now show that the Hoxa-9 protein physically interacts with Meis1 proteins. Hox proteins from the other AbdB-like paralogs, Hoxa-10, Hoxa-11, Hoxd-12, and Hoxb-13, also form DNA binding complexes with Meis1b. DNA binding complexes formed by Meis1 with Hox proteins dissociate much more slowly than DNA complexes with ... | SIGNOR-241226 |
Q8TBB1 | Q96KB5 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.375 | We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous su... | SIGNOR-272898 |
Q9UHD2 | Q15025 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.375 | TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 | SIGNOR-275733 |
Q13315 | Q9UBU7 | 1 | phosphorylation | down-regulates | 0.375 | Dbf4/cdc7 (dbf4-dependent kinase (ddk)) is activated at the onset of s-phase, and its kinase activity is required for dna replication initiation from each origin. We identified novel atm/atr phosphorylation sites on dbf4 and showed that atm/atr-mediated phosphorylation of dbf4 is critical for the intra-s-phase checkpoi... | SIGNOR-177793 |
P17252 | P38936 | 1 | phosphorylation | up-regulates activity | 0.375 | Binding of calmodulin to the carboxy-terminal region of p21 induces nuclear accumulation via inhibition of protein kinase c-mediated phosphorylation of ser153| When phosphorylated at Ser153, p21 is located at the cytoplasm and disrupts stress fibers. | SIGNOR-139302 |
Q9Y4L5 | P00533 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.375 | RNF126 and Rabring7 associate with the EGFR through a ubiquitin-binding zinc finger domain and both E3 ubiquitin ligases promote ubiquitylation of EGFR. In HeLa cells depleted of either RNF126 or Rabring7 the EGFR is retained in a late endocytic compartment and is inefficiently degraded. | SIGNOR-272104 |
P42229 | P11309 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.375 | The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting bec... | SIGNOR-249621 |
P84022 | P49715 | 1 | binding | down-regulates activity | 0.375 | Thus, repression of the activity of C/EBPs by Smad3/4 at C/EBP binding sites inhibited transcription from the PPAR2 and leptin promoters | SIGNOR-241924 |
Q92915 | Q99250 | 1 | binding | down-regulates activity | 0.375 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253429 |
P58417 | Q9Y4C0 | 1 | binding | up-regulates | 0.375 | We show that neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual lns domain, the second overall lns domain in all three alpha-neurexins. | SIGNOR-60643 |
Q9NPA2 | P08253 | 1 | cleavage | up-regulates activity | 0.375 | Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond. Leukolysin Cleaves ProMMP-2 at Asn66-Leu and Asn109-Tyr. | SIGNOR-256345 |
P07948 | O60711 | 1 | phosphorylation | up-regulates activity | 0.375 | Of a total of 11 tyrosine sites in LPXN, we mutated Tyr(22), Tyr(72), Tyr(198), and Tyr(257) to phenylalanine and demonstrated that LPXN was phosphorylated by Lyn only at Tyr(72) and that this tyrosine site is proximal to the LD3 domain. We further show that LPXN suppressed the secretion of interleukin-2 by BCR-activat... | SIGNOR-262892 |
Q99608 | Q9Y6B2 | 1 | binding | up-regulates activity | 0.375 | The Prader-Willi syndrome protein necdin interacts with the E1A-like inhibitor of differentiation EID-1 and promotes myoblast differentiation. | SIGNOR-237614 |
P31751 | Q15118 | 2 | phosphorylation | up-regulates activity | 0.375 | Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex. | SIGNOR-277271 |
P06213 | P0DP25 | 1 | phosphorylation | down-regulates | 0.375 | The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecu... | SIGNOR-266336 |
P50406 | P38405 | 1 | binding | up-regulates activity | 0.375 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256944 |
P31751 | P15311 | 1 | phosphorylation | up-regulates | 0.375 | Purified akt directly phosphorylates recombinant ezrin at threonine 567 in vitro in an atp-dependent manner. ezrin activation after initiation of na+-glucose cotransport requires akt2 expression | SIGNOR-130260 |
Q8N6U8 | P63092 | 1 | binding | up-regulates activity | 0.375 | Shh signaling directs Gpr161 to be internalized from cilia, preventing its activity. | SIGNOR-259936 |
Q15118 | P31751 | 2 | phosphorylation | up-regulates activity | 0.375 | Since both AKT-1, AKT-2, and SGK-1 are phosphorylated by PDK-1 and are themselves capable of phosphorylating DAF-16, their direct contact may reflect a temporary, regulatory interaction.|This demonstrates that functional PDK-1 is required to activate AKT-1, AKT-2, and SGK-1 in vivo. | SIGNOR-279248 |
Q9NPA3 | Q13085 | 1 | binding | up-regulates activity | 0.375 | Recently, we reported the discovery that MIG12, a 183 amino acid protein, binds to ACC1 and ACC2, which induces polymerization and subsequently increases the enzymatic activity of the protein | SIGNOR-267111 |
P28221 | P09471 | 1 | binding | up-regulates activity | 0.375 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257000 |
Q13639 | P38405 | 1 | binding | up-regulates activity | 0.375 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256912 |
P10398 | Q15599 | 1 | phosphorylation | up-regulates activity | 0.375 | We also identify A-Raf as a kinase necessary for E3KARP phosphorylation at the G2/M stage of the cell cycle. Phosphorylation of Ser-303 regulates the localization, function, and dynamics of E3KARP | SIGNOR-273503 |
P24941 | P53350 | 1 | phosphorylation | up-regulates activity | 0.375 | Thus, CycA2-CDK2 can stimulate phosphorylation of PLK1 T210 in vitro and the interactions required for CycA2-mediated PLK1 T210 phosphorylation are detected in the cytoplasm, but not in the nucleus.|We find that Cyclin A2-CDK2 can activate the mitotic kinase PLK1 through phosphorylation of Bora, and that only cytoplasm... | SIGNOR-280212 |
P19784 | P52655 | 1 | phosphorylation | up-regulates activity | 0.374 | We now show that human TFIIA is phosphorylated in vivo on serine residues that are partially conserved between yeast and human TFIIA large subunits. Alanine substitution mutation of serine residues 316 and 321 in TFIIA alphabeta reduced TFIIA phosphorylation significantly in vivo. Additional alanine substitutions at se... | SIGNOR-250996 |
Q13153 | P16949 | 1 | phosphorylation | down-regulates | 0.374 | The hgf-induced wave2 transport, lamellipodia formation, stathmin/op18 phosphorylation at ser38 and binding to kinesin-wave2 complex, but not stathmin/op18 phosphorylation at ser25 and microtubule growth, were abrogated by pak1 inhibitor ipa-3 | SIGNOR-183503 |
P31749 | P17542 | 1 | phosphorylation | down-regulates | 0.374 | Akt phosphorylates tal1 oncoprotein and inhibits its repressor activity. / our results show that akt specifically phosphorylates thr90 of the tal1 protein within its transactivation domain in vitro and in vivo. | SIGNOR-252479 |
P14136 | P60709 | 1 | binding | up-regulates quantity | 0.374 | GFAP is the major cytoskeletal element and scaffold of astrocytes In astrocytes, GFAP has close interaction with F-actin molecularly and functionally. | SIGNOR-269271 |
P18031 | P08922 | 1 | dephosphorylation | down-regulates | 0.374 | In an approach to gain insight into the sequence-dependent dephosphorylation of multiple phosphotyrosyl-containing peptides by the phosphatases shp-1 and ptp1b, we applied a chromatographic technique for the analysis of the dephosphorylation products. | SIGNOR-154199 |
P06239 | P60484 | 1 | phosphorylation | up-regulates | 0.374 | Thus, y240a and y315a are involved in the ability of mmac/pten to dephosphorylate ptdins and regulate tumor cell growth in vitro and in vivo. | SIGNOR-116499 |
P30559 | P14416 | 1 | binding | up-regulates activity | 0.374 | Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling. Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling. | SIGNOR-270333 |
P46934 | Q9Y4H2 | 1 | ubiquitination | up-regulates activity | 0.374 | Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin binding protein. | SIGNOR-278659 |
P19784 | Q9Y5B0 | 1 | phosphorylation | down-regulates activity | 0.374 | We found that only phosphorylated FCP1 can physically interact with TFIIF. We set out to purify an FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negative effect on FCP1-associated activities.| Phosphorylation of FCP1 by CK2 Inhibits the Transcription Elongation Activity of... | SIGNOR-250986 |
Q969X5 | Q9Y282 | 1 | binding | up-regulates quantity by stabilization | 0.374 | Among novel cycling proteins we have characterized ERGIC-32, a new ERGIC protein that interacts with human Erv46, a protein previously characterized in yeast and functioning in ER to Golgi protein trafficking. ERGIC-32 interacts with human Erv46 (hErv46) as revealed by covalent cross-linking and mistargeting experiment... | SIGNOR-260637 |
P28482 | Q9NXR1 | 1 | phosphorylation | up-regulates activity | 0.374 | Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro. In the case of Nudel, the phosphorylation sites were also located in the S/TP motifs. Detailed mutagenesis study indicated that T219, S242, and T245 were phosphorylated by Cdc2, while T219 and T245 were phosphorylated by Erk2.|Phosphorylation of Nud... | SIGNOR-249422 |
Q13438 | Q9HBA0 | 1 | binding | up-regulates quantity by stabilization | 0.374 | Here we report that OS-9, a ubiquitously expressed endoplasmic reticulum (ER)-associated protein, interacts with the cytosolic N-terminal tail of TRPV4.Thus, OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation. Our data s... | SIGNOR-261064 |
P48730 | P10636 | 1 | phosphorylation | down-regulates | 0.374 | Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.Here we characterized the contribution of one ck1 isoform, ckidelta, to the phosphorylation of tau at residues ser202/thr205 and ser396/ser404 in human embryonic kidney 293 cells. | SIGNOR-121717 |
P62136 | P51955 | 1 | dephosphorylation | down-regulates | 0.374 | Nek2 is activated by autophosphorylation, and its dephosphorylation is catalyzed by pp1 | SIGNOR-152949 |
Q86T96 | O95409 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.374 | Rinescan directly interact with Zic2. the ubiquitination of endogenous Zic2 was enhanced by Myc-Rines in rat neural stem cellline MNS70 cells. Rines-induced degradation of Zic2 | SIGNOR-226303 |
O60858 | Q00987 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.374 | Here, we demonstrate that overexpression of RFP2 in cells induced apoptosis through proteasomal degradation of MDM2 and AKT. We observed that RFP2 formed a complex with MDM2, a negative regulator of the p53 tumor suppressor, and AKT, a regulator of apoptosis inhibition at the cellular level. Additionally, we found tha... | SIGNOR-271851 |
P36894 | A6ND36 | 1 | phosphorylation | up-regulates activity | 0.374 | These results indicate that ALK3 phosphorylates PAWS1 predominantly at Ser610 but can also phosphorylate at Ser614 and Ser616 in vitro. |Here, we report the discovery and characterization of PAWS1/FAM83G as a novel SMAD1 interactor. PAWS1 forms a complex with SMAD1 in a SMAD4-independent manner, and BMP signalling indu... | SIGNOR-264766 |
P00519 | Q06124 | 1 | phosphorylation | up-regulates activity | 0.374 | Direct phosphorylation of SHP-2 by Abl kinases (Y580) promotes sustained activation of SHP-2 signaling and proliferation, and c-Abl/Abl-Related Gene-dependent activation of tyrosine kinase X further potentiates SHP-2 signaling by phosphorylating SHP-2 on Y63.|Endogenous Abl kinases phosphorylate SHP-2 on Y580 and induc... | SIGNOR-278217 |
P68400 | P33527 | 1 | phosphorylation | up-regulates | 0.374 | Casein kinase 2_ regulates multidrug resistance-associated protein 1 function via phosphorylation of thr249. This study supports a model in which ck2_ potentiates mrp1 function via direct phosphorylation of thr249. | SIGNOR-197844 |
O00399 | P53350 | 1 | binding | up-regulates activity | 0.374 | Here, we show that the p27/p25 heterodimer undergoes mitotic phosphorylation by cyclin‐dependent kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo‐like kinase 1 (Plk1) at kinetochores. | SIGNOR-264798 |
P23327 | P16615 | 1 | binding | down-regulates activity | 0.374 | Furthermore, a Ser96Asp HRC variant, which mimics constitutive phosphorylation of Ser96, diminished delayed aftercontractions in HRC null cardiac myocytes. This HRC phosphomimetic variant was also able to rescue the aftercontractions elicited by the Ser96Ala variant, demonstrating that phosphorylation of Ser96 is criti... | SIGNOR-273662 |
Q13148 | Q9UPY3 | 1 | post transcriptional regulation | up-regulates quantity | 0.374 | Molecularly, we observed that TBPH regulates the expression levels of Dicer-2 by direct protein-mRNA interactions in vivo.|In agreement with this idea, we found that the suppression of TDP-43 induces the downregulation of Dicer in human neuroblastoma cell lines signifying that the TDP-43 function is required to prevent... | SIGNOR-262114 |
P27361 | Q96RK0 | 1 | phosphorylation | down-regulates | 0.374 | Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3)[...] These results suggest that erk phosphorylation of s... | SIGNOR-169879 |
P06493 | P52926 | 1 | phosphorylation | down-regulates | 0.374 | Architecture of high mobility group protein i-c dna complex and its perturbation upon phosphorylation by cdc2 kinase. Phosphorylation by cdc2 reduces binding strength of the mammalian and insect hmgi proteins to dna. After phosphorylation of the protein at ser-43 and ser-58 by cdc2 kinase multiple contacts of dbds, esp... | SIGNOR-74098 |
P28482 | P12270 | 1 | phosphorylation | up-regulates | 0.374 | Tpr is phosphorylated by erk2 at four different sites. / because phosphorylation of tpr by activated erk stabilizes their interaction, we hypothesize that this phosphorylation is not part of a signal amplification cascade but rather positions activated erk to perform a continuing function in the nuclear pore. | SIGNOR-181022 |
Q00535 | P50406 | 1 | phosphorylation | down-regulates activity | 0.374 | Cdk5 phosphorylates the 5-HT6R on serine 350 (Ser350)|This suggests that the 5-HT6R is unable to interact with GPRIN1 when it is phosphorylated by Cdk5. | SIGNOR-264407 |
Q13627 | P01106 | 1 | phosphorylation | down-regulates quantity | 0.374 | We also found that DYRK1A phosphorylated c-Myc on Ser62, priming phosphorylation on Thr58 by GSK3\u03b2 and subsequent degradation.|c-Myc expression is down-regulated by DYRK1A. | SIGNOR-279609 |
Q00535 | P16220 | 1 | phosphorylation | up-regulates activity | 0.374 | CDK5 Activates the Self-Renewal Regulator CREB1 in GSCs.|Our data indicate that CDK5, which has previously been shown to activate CREB1 through cAMP and PKA in dopamine neurons present in the ventral tegmental area, can directly bind with and phosphorylate CREB1 in a PKA and cAMP independent manner, at least in GSCs. | SIGNOR-279682 |
Q9UQC2 | A7KAX9 | 1 | relocalization | up-regulates | 0.374 | Gc-gap, a rho family gtpase-activating protein that interacts with signaling adapters gab1 and gab2we propose that gab1 and gab2 in cooperation with other adapter molecules might regulate the cellular localization of gc-gap under specific stimuli. | SIGNOR-102628 |
Q15262 | P40763 | 1 | dephosphorylation | down-regulates activity | 0.374 | In this study, we investigated whether receptor-type tyrosine protein phosphatase kappa (PTPRK), the only protein tyrosine phosphatase at 6q that contains a STAT3 specifying motif, negatively regulates STAT3 activation in NKTCL.|Phosphatase substrate-trapping mutant assays demonstrated the binding of PTPRK to STAT3, an... | SIGNOR-277060 |
P27361 | P78347 | 1 | phosphorylation | up-regulates | 0.374 | Tfii-i can be phosphorylated in vitro by erk and mutation of consensus map kinase substrate sites at serines 627 and 633 impairs the phosphorylation of tfii-i by erk and its activity on the c-fos promoter. These results suggest that erk regulates the activity of tfii-i by direct phosphorylation. | SIGNOR-74308 |
P23946 | P14138 | 1 | cleavage | up-regulates activity | 0.374 | Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products. | SIGNOR-256355 |
Q9Y625 | P41221 | 1 | binding | down-regulates activity | 0.374 | GPC6 binds to Wnt5a and inhibits its release from producing cells. Based on theseresults, and in our finding that GPC6 inhibits non-canonical Wnt signaling in the developing intestine,we tested the hypothesis that GPC6 binds to Wnt5aat the surface of the Wnt5a-producing mesenchymalcells and restrains its release from t... | SIGNOR-264030 |
Q96DA2 | Q9NRD5 | 1 | binding | up-regulates activity | 0.374 | GTP-bound RAB39B interacts with PICK1. In line with evidence that PICK1 can dimerize, the structural model suggests that dimerization of PICK1 is a prerequisite for simultaneous recognition of both RAB39B and GluA2 each by one of the PICK1 molecules in the PICK1 dimer (Fig. 6a–c). The existence of such complex is suppo... | SIGNOR-264045 |
P45983 | Q05639 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.374 | Ribosome-associated JNK phosphorylates the eukaryotic translation elongation factor 1A isoform 2 (eEF1A2) on serines 205 and 358 to promote degradation of NSPs by the proteasome. | SIGNOR-276492 |
O60481 | P10071 | 1 | binding | up-regulates | 0.374 | Zic3 functions as a transcriptional coactivator of gli3 when it physically associates with gli3 | SIGNOR-157637 |
O15327 | P31749 | 1 | dephosphorylation | down-regulates activity | 0.374 | Further, we show that INPP4B but not PTEN is able to reduce tyrosine phosphorylation of Akt1 and both the lipid and PTP activity of INPP4B likely contribute to the reduction of Akt1 phosphorylation.|Further, we show that INPP4B but not PTEN is able to reduce tyrosine phosphorylation of Akt1 and both the lipid and prote... | SIGNOR-277106 |
O43586 | P50570 | 1 | binding | down-regulates | 0.374 | We show that pstpip1 associates with the regulator of endocytosis, dynamin 2, and pstpip1 expression impairs transferrin uptake and endocytosis | SIGNOR-178628 |
P15172 | P30281 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.374 | Here we report that, at the onset of differentiation, activation by MyoD of the Rb, p21, and cyclin D3 genes occurs in the absence of new protein synthesis and with the requirement of the p300 transcriptional coactivator. | SIGNOR-238526 |
Q99750 | P15173 | 1 | binding | down-regulates activity | 0.374 | We demonstrate that I-mf inhibits the transactivation activity of the MyoD family and represses myogenesis. I-mf associates with MyoD family members and retains them in the cytoplasm by masking their nuclear localization signals. | SIGNOR-240493 |
Q8N2H9 | O43353 | 1 | ubiquitination | up-regulates activity | 0.374 | Pellino3 directly bound to the kinase RIP2 and catalyzed its ubiquitination | SIGNOR-280452 |
P24941 | P49459 | 1 | phosphorylation | up-regulates | 0.374 | Hhr6a is phosphorylated in vitro by cdk-1 and -2 on ser120, a residue conserved in all hhr6a homologues, resulting in a 4-fold increase in its ubiquitin-conjugating activity. | SIGNOR-116508 |
Q5JRX3 | P05067 | 1 | cleavage | down-regulates activity | 0.373 | In the present study we have identified and characterized the human PreP homologue, hPreP, in brain mitochondria, and we show its capacity to degrade the amyloid beta-protein (Abeta). PreP belongs to the pitrilysin oligopeptidase family M16C containing an inverted zinc-binding motif. We show that hPreP is localized to ... | SIGNOR-260661 |
Q8IZU9 | P78352 | 1 | binding | up-regulates activity | 0.373 | We here report that, through its C-terminal PDZ domain-binding motif, Neph2 directly interacts with postsynaptic density (PSD)-95, an abundant excitatory postsynaptic scaffolding protein. Moreover, Neph2 protein is detected in the brain PSD fraction and interacts with PSD-95 in synaptosomal lysates. Functionally, loss ... | SIGNOR-269079 |
A6ND36 | P48729 | 1 | binding | up-regulates quantity | 0.373 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273745 |
Q13131 | Q9GZT9 | 1 | phosphorylation | down-regulates activity | 0.373 | Mechanistically, AMPKα1 directly phosphorylated prolyl hydroxylase domain-containing (PHD)2 at serines 61 and 136, which suppressed PHD2-dependent hydroxylation of hypoxia-inducible factor (HIF)1α and subsequent regulation of hepatic hepcidin-related iron signalling. | SIGNOR-277592 |
P24158 | P55085 | 1 | cleavage | down-regulates activity | 0.373 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263601 |
Q9UHD2 | Q13546 | 2 | phosphorylation | down-regulates activity | 0.373 | Our data clearly indicate that TBK1 can directly phosphorylate RIPK1 at T189.|TBK1 inhibits RIPK1 by direct phosphorylation. | SIGNOR-279388 |
P28482 | Q13322 | 1 | phosphorylation | up-regulates | 0.373 | We show that grb10 is a direct substrate of the p42/44 mitogen-activated protein kinase (mapk)we identified ser(150), ser(418), and ser(476) of human grb10zeta as mapk-mediated in vitro phosphorylation sites. Replacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimu... | SIGNOR-138163 |
P60484 | P51149 | 1 | dephosphorylation | up-regulates activity | 0.373 | PTEN dephosphorylates Rab7 on two conserved residues S72 and Y183, which are necessary for GDP dissociation inhibitor (GDI)-dependent recruitment of Rab7 on to late endosomes and subsequent maturation. | SIGNOR-276960 |
P08173 | P09471 | 1 | binding | up-regulates activity | 0.373 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256965 |
Q15349 | Q92934 | 1 | phosphorylation | down-regulates | 0.373 | The rsks catalyze the phosphorylation of the pro-apoptotic protein bad at serine 112 to promote cell survival. | SIGNOR-184591 |
P15172 | P08047 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.373 | These data suggest a regulatory model in which MyoD activation during myogenesis causes the down-regulation of Sp1, which contributes to the repression of GLUT1 gene transcription and, therefore, leads to the reduction in GLUT1 expression and glucose transport. | SIGNOR-241765 |
Q16654 | P11498 | 1 | phosphorylation | down-regulates activity | 0.373 | PDK4 phosphorylates and inhibits the pyruvate dehydrogenase complex (PDC) which catalyzes the conversion of pyruvate to acetyl-CoA in the glucose oxidation pathway. | SIGNOR-278974 |
Q06124 | P31260 | 1 | dephosphorylation | up-regulates | 0.373 | We also identified hoxa10 as a substrate for shp2 in undifferentiated myeloid cells, an effect that diminished during myelopoiesis. However, a constitutively active form of shp2 dephosphorylated hoxa10 throughout ex vivo myelopoiesis and sustained repression of hoxa10 target genes involved in phagocyte effector functio... | SIGNOR-182475 |
P56178 | P10451 | 1 | transcriptional regulation | up-regulates quantity | 0.373 | Dlx5 initiates a complete osteogenic differentiation in these early primary cells, by triggering Runx2, osteopontin, alkaline phosphatase, and other gene expression according to the sequential temporal sequence observed during skull osteogenesis in vivo. | SIGNOR-245340 |
Q9UIF7 | Q92547 | 1 | binding | up-regulates | 0.373 | Binding of myh directly participates in atr and topbp1 activation in dna damage signaling, leading to apoptosis. | SIGNOR-173972 |
Q92847 | P63096 | 1 | binding | up-regulates activity | 0.373 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257054 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.