smiles
stringlengths
11
267
CMPD_CHEMBLID
stringlengths
7
13
exp
float64
-1.5
4.5
Cc1cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cc(c1)C(=O)N
CHEMBL1224140
2.08
NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1
CHEMBL1223873
1.61
CNC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1
CHEMBL1224286
1.93
NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c(F)c1
CHEMBL1224216
2.1
Cc1cc(ccc1O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)C(=O)N
CHEMBL1224215
2.23
Oc1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1
CHEMBL1224288
2.3
Cc1c(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cccc1C(=O)N
CHEMBL1224142
1.6
NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1
CHEMBL1223951
1.76
CCC(CC)NC(=O)c1cnn(C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1916269
0.36
CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934268
0.95
C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)C(C)(C)C
CHEMBL1934270
1.84
CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934271
1.88
COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934417
0.78
C[C@H](NC(=O)c1c(C)nn(CC(F)(F)F)c1NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C
CHEMBL1934269
0.93
CC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934267
0.97
CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934266
0.92
COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2
CHEMBL1934416
0.61
NC(Cc1c[nH]c2ccccc12)C(=O)O
CHEMBL484901
-1.17
CC(C)NCC(O)COc1cccc2[nH]ccc12
CHEMBL500
-0.12
N[C@H](Cc1c[nH]c2ccccc12)C(=O)O
CHEMBL292303
-0.92
CCc1cccc2c(cn(CC(=O)NCCOC)c12)C#N
CHEMBL1560828
1.95
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
CHEMBL128
-0.96
OC(=O)CSc1c[nH]c2ccccc12
CHEMBL1892245
-1.31
Clc1ccc2[nH]ccc2c1
CHEMBL555013
3.28
NCCCCCc1c[nH]c2ccc(F)cc12
CHEMBL1630742
0.6
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
CHEMBL54976
-1.08
Fc1ccccc1COc2cc(OCCCN3CCCC3)ccc2C(=O)Nc4ccccc4
CHEMBL1824606
3.85
Fc1cccc(COc2cc(OCCCN3CCCC3)ccc2C(=O)Nc4ccccc4)c1
CHEMBL1824608
3.67
Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cccc(F)c4)c1
CHEMBL1824371
3.15
Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cccc(c4)C#N)c1
CHEMBL1824373
2.41
Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4C#N)c1
CHEMBL1824369
2.34
Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccc(F)cc4)c1
CHEMBL1824364
3.2
Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4)c1
CHEMBL1824363
3.07
O=C(Nc1ccccc1)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4C#N
CHEMBL1824605
2.66
CN(c1ccccc1)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2
CHEMBL1762521
3.47
COc1ccc(C)c(c1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2
CHEMBL1762527
3.18
CN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C
CHEMBL1762530
2.94
COc1cc(CO)cc(c1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2
CHEMBL1762529
3
CN(c1cccc(CO)c1)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2
CHEMBL1762528
2.6
CC(C)N(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C
CHEMBL1762548
3.9
CCN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C
CHEMBL1762547
3.8
COCCN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C
CHEMBL1762549
2.8
CC(C)Oc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C
CHEMBL365472
3.1
COc1ccc(cc1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2Br
CHEMBL184347
3.49
COc1cc(cc(OC)c1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C
CHEMBL186542
2.54
COc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C
CHEMBL184011
3.17
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2
CHEMBL186526
2.65
COc1ccc(cc1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C
CHEMBL413558
3.12
COCCOc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C
CHEMBL184189
2.74
COc1ccc(cc1OC)C(=O)Nc2cccc(NC(=O)c3cccc(c3)N(C)C)c2
CHEMBL183843
3.67
CCC(N(CCCN)C(=O)c1ccc(OC)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4
CHEMBL1829409
1.39
CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(Cl)cc4
CHEMBL1829249
2.32
CCC(NC(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4
CHEMBL1829442
4.14
CCC(N(CCCN)C(=O)c1ccccc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4
CHEMBL1829270
1.38
CCC(N(CCCN)C(=O)c1ccc(cc1)C(C)C)C2=Nc3ccsc3C(=O)N2Cc4ccccc4
CHEMBL1829408
2.72
CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(C)cc4
CHEMBL1829250
1.69
CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(OC)cc4
CHEMBL1829251
2.15
CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4
CHEMBL1829246
1.81
COc1ccc(cc1)C2=C(C)c3ccc(OC)cc3OC2=O
CHEMBL1258188
3.31
Oc1ccc(cc1)C2=Cc3ccc(O)cc3OC2=O
CHEMBL1915315
2.9
Oc1ccc2OC(=O)C(=Cc2c1)c3ccccc3
CHEMBL467028
3.12
O=C1Oc2ccccc2C=C1c3ccccc3
CHEMBL510349
3.22
Oc1ccc(cc1)C2=Cc3cc(O)ccc3OC2=O
CHEMBL486894
2.9
Oc1ccc(cc1)C2=Cc3ccccc3OC2=O
CHEMBL71271
3
Oc1ccc(cc1)C2=Cc3cccc(O)c3OC2=O
CHEMBL1777848
2.8
CC1=C(C(=O)Oc2cc(O)ccc12)c3ccc(O)cc3
CHEMBL1255978
2.8
COCCS(=O)(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2
CHEMBL514384
2.75
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)CCN(C)C)n2
CHEMBL477785
2.52
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)C)n2
CHEMBL477568
2.39
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CN(C)C)n2
CHEMBL478241
3.31
CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CO)ncc2F
CHEMBL476993
2.19
C[C@H](O)C(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2
CHEMBL515311
2.15
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CO)n2
CHEMBL477786
1.69
CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)C)n2
CHEMBL477567
2.57
CN(C)CC(O)COc1ccc(Nc2cc(Nc3cc(C)ccc3Cl)ncn2)cc1
CHEMBL100675
2.16
CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#N)c3cc(Cl)ccc3Cl)cc1
CHEMBL101119
2.1
CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#C)c3cc(Cl)ccc3Cl)cc1
CHEMBL100945
2.8
CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#N)c3ccc(C)cc3Br)cc1
CHEMBL421583
2.24
CN(C)CC(O)COc1ccc(Nc2cc(Nc3cc(Cl)ccc3Cl)ncn2)cc1
CHEMBL322640
2.6
CN(C)CC(O)COc1ccc(Nc2cc(Nc3ccc(F)cc3F)ncn2)cc1
CHEMBL317281
1.48
CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CCC#N)c3cc(Cl)ccc3Cl)cc1
CHEMBL317378
2.1
COc1ccc(Nc2cc(Nc3ccc(OCC(O)CN(C)C)cc3)ncn2)cc1
CHEMBL101779
1.5
OC(=O)COc1ccc(cc1CN2CCN(CC2)S(=O)(=O)c3ccccc3)C(F)(F)F
CHEMBL1689110
0.4
C[C@H]1CN(Cc2cc(Cl)ccc2OC(C)(C)C(=O)O)CCN1S(=O)(=O)c3ccccc3
CHEMBL1689134
0.54
CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3
CHEMBL1689124
1.02
CC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3
CHEMBL1689123
0.44
OC(=O)COc1ccc(Cl)cc1CN2CCN(CC2)S(=O)(=O)c3ccccc3
CHEMBL1689109
0.49
OC(=O)COc1ccc(Cl)cc1CN2CCN(CC2)S(=O)(=O)c3ccc(F)cc3
CHEMBL1689117
0.99
CC1CN(CCN1Cc2cc(Cl)ccc2OCC(=O)O)S(=O)(=O)c3ccccc3
CHEMBL1689122
0.69
CC1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3
CHEMBL1689118
0.31
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)C)C(=O)C(F)(F)F
CHEMBL111955
1.77
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)N)C(=O)C(F)(F)F
CHEMBL109396
1.17
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC=O)C(=O)C(F)(F)F
CHEMBL66520
1.84
CCNC1=CC=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccccc2
CHEMBL325870
2.37
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)C(F)(F)F)C(=O)C(F)(F)F
CHEMBL323443
1.01
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)N)C(=O)C(F)(F)F
CHEMBL13923
1.74
CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)C)C(=O)C(F)(F)F
CHEMBL418841
1.78
CNS(=O)(=O)NC1=CC=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccccc2
CHEMBL279250
1.79
CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
CHEMBL235191
0.82
Cc1cccc(C(=O)N)c1NC(=O)c2ccccc2
CHEMBL151592
1.09