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Compound Name,Synthesization |
3.1 METHYLPHENIDATE (11968),"Methylphenidate (3.1.6) has been synthesized via condensation of phenylacetonitrile (3.1.1) with a 2-chloropyridin (3.1.2) at 110112C in toluene in the presence of NaNH2, which gave 2-phenyl-2-(pyridin-2-yl)acetonitrile (3.1.3). The last was hydrolyzed to corresponding amide (3.1.4), which... |
3.2 PERHEXILINE (1216),"The synthesis of racemic perhexiline is based on nucleophilic addition of lithiated 2-picoline (3.1.7) to dicyclohexyl ketone (3.1.8) to give the corresponding tertiary alcohol (3.1.9), which undergoes HCL mediated dehydration forming alkene (3.1.10), the subsequent hydrogenation of which cataly... |
3.3 PIPRADROL (259),"Pipradrol (3.1.17) was synthesized from pyridyl Grignard reagent prepared from 2-pyridyl bromide (3.1.15) and bezophenone (3.1.12), which gave diphenylpydinemethanol (3.1.16) reduced catalytically to desired pipradrol (3.1.17) [31,32]. Enantiomers of pipradrol were synthesized from (R)- and (S)- pi... |
3.4 MEFLOQUINE (5370),"The synthesis of mefloquine (3.1.27) began with the synthesis quinolin-4- ol (3.1.21) obtained by polyphosphoric acid condensation of the ethyl 4,4,4- trifluoroacetoacetate (3.1.19) with O-trifluoromethylaniline (3.1.20). A further conversion of prepared (3.1.21) by POBr3 into the 4-bromoquinolin... |
3.5 MEPIVACAINE (4176),"Two basic methods for the synthesis of mepivacaine are proposed. The first comprises the transformation of ethyl 1-methylpipecolate (3.1.30) to 1-methylpiperidine-2-carboxylic acid amide with magnesium (2,6-dimethylphenyl) amide bromide (3.1.29) under reflux in ether. A magnesium derivative (3.1... |
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