TEXT stringlengths 9 6.58k | LOCATION stringlengths 1 116 | LABEL stringlengths 2 495 |
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human glucose phosphate dehydrogenase associated with nadph was efficiently bound with agarosebound nadp whereas the enzyme associated with nadp was poorly bound with agarosebound nadp after the beta of haemoglobin from haemolyzate by treatment with deaecellulose the enzyme was converted into the nadphbound form and wa... | 27 | elimination |
a quantitative method for the simultaneous determination of propranolol and its active metabolite hydroxypropranolol in HP is described plasma samples are extracted at ph with ethyl acetate after the addition of sodium bisulphite and the internal standard oxprenolol the extracts are derivatized with trifluoroacetic anh... | 15|52|83 | human plasma|detection|normal plasma |
the separation of amino acids has been achieved on a short column of chromobeads c resin with a lithium gradientelution system the analysis took h the separation of asparagine and glutamine from glutamic acid was highly dependent on the sample ph and on the methanol concentration in the first buffer of the gradient the... | 61 | human plasma |
a gas chromatographic method is described for CA of tetrazolyl thioxanthone dioxide bw c in human plasma urine and faeces after extraction into dichloroethane from alkaline medium the compound is converted to the heptafluorobutyrate derivative which is injected into a gas chromatograph and measured using a ni EC detect... | 7|47 | assay|electron capture |
simple methods to enhance the detection of pneumococci in respiratory secretions are needed sheep blood agar containing mug of gentamicin per ml was more often positive than either standard SBA or mouse inoculation in recovering pneumococci from adult and pediatric patients in adults the direct quellung test on sputum ... | 29|53|78 | sheep blood agar|sensitive|detection |
the dose dependence of the acute effects of ethanol upon liver intermediary metabolism in vivo has been demonstrated in rats ethanol was given ip in doses of and gkg in equal volumes mlkg the liver was freezeclamped min T3 injection and multiple metabolites were measured in the perchloric acid extract of the tissue eac... | 38|80|140|179 | after|groups|pattern|completely |
lorazepam and mg was compared with pentobarbital and mg for its effect on sleep in hospital insomnia subjectiveresponse data were collected by research nurses lorazepam was found to be a potent nighttime sedative to mg of lorazepam is equivalent to mg SP for measures of sleep SQ and duration at this dose level it is le... | 41|46 | sodium pentobarbital|quality |
it is proposed that the direct analgesic effect of morphine becomes att over the course of successive administrations of the narcotic by a conditioned compensatory hyperalgesic response elicited by the administration procedure the net result being analgesic tolerance using the hot plate analgesia assessment situation w... | 11|68 | attenuated|systemic |
the determination with murexide of free and proteinbound calcium in model systems of known composition ionic strength and ph was investigated the spectra of calcium murexide in the presence of varying amounts of calcium ions indicated that the absorption maximum fo calcium murexide complex occurs at nm while that of mu... | 119|166 | casein|binding |
the effect of low levels of strontium boron lithium molybdenum and fluorine alone and in combination on hydroxyapatite solubility bacterial growth and acid production in five antigenic types of streptococcus mutans was investigated pour plates containing synthetic hydroxyapatite were used to compare dissolution of hydr... | 77 | levels |
the relationship of enzymatic activity to organelle development and organelle number during differentiation of the metanephric kidney in the mouse was approached from several experimental directions PSA analyses of marker enzymes for peroxisomes catalase and damino acid oxidase mitochondria cytochrome oxidase and lysos... | 26|55|108|160|161|192 | biochemical|adult|proximal|high voltage|electron microscope|proximal |
the bone marrow reactions that is decrease of nucleated cell counts and increase of red blood cell counts of mouse bone were observed hr T3 injection of endotoxin and peaked after hr these reactions were significantly inhibited when diphenhydramine promethazine antihistamines chlorpromazine antiserotonin or cyproheptad... | 24 | after |
the interactions between pancreatic lipase and colipase and the substrate and the effect of bile salts on these interactions have been investigated by the use of kinetic experiments and studies on the semiquantitative phase distribution of lipase and colipase activities the results suggest that lipase binds to hydropho... | 71 | binding |
when plasma proteins are diluted with buffer the ionic strength and ionic composition of that buffer affects the interactions between thyroxine t and its plasma proteinbinding sites increases in phosphate chloride or barbiturate ion concentration from to mmoll caused a significant decrease in the affinity of plasma pro... | 94 | binding |
using the falckhillarp histochemical technique for monoamines evidence was found for the presence of a catecholamine in the SSG nerves of the moth manduca sexta the innervation was studied with the electron microscope only the fluidsecreting region of the gland is innervated and the nerve endings are characteristic of ... | 18|53|55|80 | salivary gland|sensitive|assay|salivary gland |
EP techniques have been employed to examine the nature of the response observed in the ectodermal slowconduction system ssi when dissolved food substances contact the column of tealia felina the response seems to consist entirely of sensory activity which may continue for periods of many T2 provided that the stimulator... | 0|45 | electrophysiological|minutes |
histamine diphosphate was shown to selectively attract human eosinophils from mixed granulocyte populations when over eosinophils were used in a modified boyden chamber chemotactic CA system this effect of histamine is abolished by incubation with diamine oxidase histaminase and was generated by decarboxylation of lhis... | 24 | assay |
comparative studies of protein structure and function can be quite interesting by themselves and even more interesting when interpreted with respect to an animals physiology in the case of fish hemoglobins some success in the latter has been achieved but there are still many unsolved problems it appears that comparativ... | 73|117 | general|function |
this paper reviews the history of understanding how biological systems can discriminate so strikingly among physically similar ions especially alkali cations appreciation of qualitative regularities permitted sequences and quantitative regularities selectivity isotherms in ion selectivity grew first from studies of ion... | 63|80|100|129 | model|intact|major|central |
visual photoreceptors from both vertebrates and invertebrates are characterized by extensive elaboration of membrane which contains visual pigment rhodopsin visual pigments in all phyla examined are chemically similar the chromophore is cis retinaldehyde attached by an aldimine linkage schiff base to a membrane protein... | 48|73|92|115|269|327 | light|light|light|membranes|preparations|membrane conductance |
a technique utilizing pregnant mares serum gonadotropin and human chorionic gonadotropin treatment of hens gallus domesticus followed by manual ovulation of the excised follicles was developed to obtain a large number of mature ova the IN ova were used to test whether acrosin partially purified from the spermatozoa of ... | 35|55|91|101|167 | intact|rabbit|collagenase|leucine aminopeptidase|release |
in order to test the range of ph values over which the titratable carried model for inorganic anion exchange is valid chloride selfexchange across human red blood cells was examined between ph and at decrees c it was found that chloride selfexchange flux had a minimum near ph and increased again with further increase i... | 178 | membranes |
the acetylcholine reversal potential er of cultured rat myotubes is mv when activated the receptor is permeable to k and na but not to cl ions measurement of er in trissubstituted nafree medium also indicated a permeability to tris ions unlike AD frog muscle the magnitude of er was insensitive to change in external ca ... | 41|100 | adult|adult |
crossreinnvervation of fast extensor digitorum longus and slow soleus twitch muscles of the rabbit showed essentially complete fast to slow and slow to fast conversion respectively mo T3 surgery with respect to a number of physiological parameters including intrinsic shortening velocity and Pt time to peak there was pr... | 27|42|61|66|94|95 | after|isometric twitch|myosin|light|complete|biochemical |
chitin synthase of mortierella vinacea was present in the microsomal fraction g precipitate the cellwall fraction g precipitate and the mitochondrial fraction g precipitate the properties of the microsomal enzyme were investigated the ph optimum was between and and the temperature optimum was between and degrees c the ... | 75|95 | heatstable|glucose |
a new method is described for the efficient conversion of schizosaccharomyces pombe cells into protoplasts the following parameters of guanine uptake determined in whole cells were unchanged in protoplasts km value requirement for an SE source sensitivity to competitive inhibitors ph optimum as well as the typical vari... | 34 | energy |
an intracellular lasparaginase with antitumour activity was purified from a strain of citrobacter the optimum conditions for enzyme production by fermentation on scales up to l were investigated highest enzyme yield was obtained in cornsteep liquor medium wv at degrees c oxygen limitation was not necessary for high enz... | 69|138 | specific|active |
some mutants and stock strains of escherichia coli k were sensitive to acriflavine in the presence of inorganic phosphate but were resistant to acriflavine in its absence they mutated spontaneously to resistance to acriflavine plus phosphate the synergistic effect of phosphate on acriflavine sensitivity was increased a... | 105|106 | acridine orange|alone |
the oxidation of carbon monoxide and methane by suspensions and ultrasonic extracts of pseudomonas methanica was studied a continuous CA for the oxidation of co to co was devised using o and co electrodes in combination stoicheiometries of codependent co formation o consumption and nadh oxidation and the partial stoich... | 19|85 | assay|nadh oxidase |
a modified version of systematic desensitization was used to reduce the anxiety and negative interpersonal consequences produced by a recurrent aversive dream resulting from events in the real world the subject a yearold incarcerated male was first taught a standard EC50 technique the subjects dream was divided into hi... | 40 | relaxation |
arteriograms of the BA i.a. reveal that dopamine given intracisternally to dogs can generate CVS this finding supports a recent hypothesis of others that dopamine may play a role in the pathogenesis of vasospasm especially since many substances are known which fail to produce such spasm compared to blood or prostagland... | 3|4|14 | basilar|artery|cerebral vasospasm |
this T0 was designed to measure the response of key enzymes of ketone body metabolism in HR skeletal muscle and liver to diet and exercise two conditions known to influence ketone body utilization a diet control high fat or high carbohydrate x kill condition rested or exhausted x training TR or untrained factorial desi... | 1|16|49|59|70|102|156|192|209 | study|heart|trained|experimental|physical training|liver|high fat|study|fatty acid |
the levels of plasma carotenoids were markedly reduced in broiler cockerels infected with eimeria acervulina or e tenella the mechanisms of this depigmentation differed between the two species being primarily associated with interference of absorption of xanthophyll carotenoids from the intestinal lumen with e acervuli... | 75 | levels |
mechanisms involved in the development of the alcoholic fatty liver in kkay mice were investigated incorporation studies using cacetate and hpalmitate indicated that the halflife of hepatic triglycerides was doubled in the ethanolingesting mice and utilization of the exogenous fat was significantly increases as compare... | 113|115|170|175 | oleic|linoleic|factors|liver |
response of the fetal kidney to MA was studied in five fetal lambs days gestation in order to evaluate the renal contribution to elimination of hydrogen ion during intrauterine development experiments were conducted on healthy unanesthetized fetuses intact in utero with catheters implanted at hysterotomy into a fetal F... | 6|48|67|83|144|242|310|361|384|387|390|415 | metabolic acidosis|femoral artery|metabolic acidosis|minutes|output|minutes|minutes|base deficit|base deficit|levels|recovery|intact |
fhr monitoring and microanalysis of fetal blood are mutually complementary procedures and optimal knowledge of the fetal state is achieved by making use of both the former for the preliminary screening of all cases at risk and the latter for the purpose of deciding on obstetric management where pathological changes are... | 209|236|395|414 | base deficit|extracellular fluid|cord blood|after |
kinetic studies were carried out on the ring opening of the quaternary nitrogen cation coralynium ion i to yield acetylpapaverine iii on the cyclization of iii to yield i and on a photochemical reaction undergone by i in aqueous solutions exposed to visible light from the results it was concluded that a i and iii are i... | 180 | hydroxide |
hydrolysis of mazindol to form aminoethylpchlorophenylhydroxyphthalimidine was followed spectrophotometrically in AQ solutions at temperatures between and degree ph values up to and an ionic strength of the effects of acetate formate and phosphate buffers as well as ionic strength on the observed rate constants were in... | 10 | aqueous |
the apparent solubility of HMM in AQ solutions suitable for intravenous use was increased by complexation with gentisic acid studies were carried out in the ph range unprotonated hexamethylmelamine did not form complexes with the gentisate ion while the hexamethylmelammonium ion appeared to form several different compl... | 4|6 | hexamethylmelamine|aqueous |
the inhibitory effect of dioctyl sodium sulfosuccinate on the proteolytic activity of trypsin was investigate over the ph range the antitryptic activity was determined using two different substrates casein and nalphabenzoyldlargininepnitroanilide hydrochloride the mechanistic studies revealed the substrateinhibitor int... | 64|102|106 | casein|inhibitory|surfactant |
the adsorption of diphenoxylate hydrochloride a potent antidiarrheal agent on activated charcoal powder was studied in vitro langmuir adsorption isotherms were established at ph and and the maximum adsorption capacity of charcoal for this drug was estimated using these values AC modified the BA of diphenoxylate hydroch... | 40|43|102 | activated charcoal|bioavailability|bioavailability |
the binding of bile salts to cholestyramine was studied under varying conditions of ph and added electrolyte the taurineconjugated bile salts were strongly absorbed by the anionexchange resin at low ph and in the presence of chloride anions glycocholic acid IB was very weak at low ph but increased strongly with increas... | 40 | binding |
camodiaquin accumulation by washed erythrocyte S9 was characterized to permit comparisons with chloroquine accumulation erythrocytes INF with plasmodium berghei cs chloroquinesusceptible accumulate amodiaquin by a saturable process that has an apparent dissociation constant for amodiaquin of x m and is competitively in... | 5|15|153|187|192|201 | preparations|infected|infected|glucose|infected|function |
postmortem brain material from control and parkinsons disease patients was examined to elucidate further the neurochemistry of this disease and to determine the mechanism of action of ldopa as a therapeutic agent the MICs of laromatic amino acid decarboxylase dopa d tyrosine hydroxylase monoamine oxidase and catecholom... | 33|47|69|95|98|185 | activities|transferase|parkinsonian patients|monoamine oxidase|transferase|responders |
these experiments were designed to study the mechanism of depletion of dopamine da in the striatum produced by alphamethylmtyrosine alphammt alphamethylmtyramine alphammta the metabolite of alphammt appears to be the AS dadepleting agent since the administration of a decarboxylase inhibitor before alphammt markedly red... | 30|51|150|225|243|250 | active|depletion|specific|release|sites|depletion |
gastric acid responses to the test meals were measured in the heidenhain pouch gastric and pancreatic fistula dogs using the intragastric titration method and monitoring the rate at which a solution of nnaoh had to be added to maintain the ph of the gastric content constant at preselected values ranging from to in this... | 87|218|243|276 | pentagastrin|liver|secretin|gastric acid secretion |
the experiments were done on single nodes of ranvier of rana esculenta the effects of tetrodotoxin and h ions were determined either by the reduction of the maximum rate of rise va of action potentials evoked with threshold stimuli or in the Vc clamp by the decrease of the peak na permeability pna with the tetrodotoxin... | 42|234|288 | voltage|after|voltage |
the experiments were done on single myelinated nerve fibres of rana esculenta the rates of toxin effect were studied either by measuring the maximum rate of rise va of repetitively evoked action potentials or by measuring na currents during periodic impulses in the Vc clamp va measurements showed that in ALP solutions ... | 43|50|86|95 | voltage|alkaline|voltage|time constant |
in diphasic BA media trypanosoma vespertilionis developed spheroid clusters as compared to rather long sausageshaped sometimes branched clusters formed by trypanosoma dionisii the former species attained a greater population density approximately x organismsml than the latter approximately x organismsml greater numbers... | 2|69|91|143|155|157 | blood agar|depletion|after|specific|heterologous|specific |
a study has been made of the formation of synapses in developing reinnervated and crossreinnervated amphibian twitch muscles which receive either a focal iliofibularis or a distributed sartorius innervation from en plaque nerve terminals using histological ultrastructural and electrophysiological techniques during the ... | 157|250|268|306 | development|contralateral|development|adult |
AA and tertiary amino homologs of the title compounds have been prepared bearing an nisopropyl group in peripheral evaluation certain members of the series exhibited betaadrenergic agonist effects of lower activity than isoproterenol nmethylnisopropyldihydroxytetralin exhibited marked properties consistent with its bei... | 0 | secondary |
apparent values of km and vmax have been measured for catalysis of hydrolysis of unsonicated PC liposomes activated through addition of m nhexanol by phospholipases a from bee and snake venoms and by phospholipase c from clostridium welchii as a function of the concentration of three surfactants hexadecylamine hexadecy... | 15 | egg lecithin |
the isolated skin of the toad bufo marinus ictericus when impaled from the outer surface by glass microelectrodes filled with m kcl shows a voltage profile which is a continuous function of the depth of impalement the superficial intraepithelial potential difference measured with reference to the external solution pdi ... | 92|133|205|225|248|271 | sites|stratum corneum|diffusion|stratum corneum|stratum corneum|shortcircuit current |
the quality of ultrastructural preservation of the avian erythrocyte achieved using various fixation techniques is evaluated different combinations of initial fixatives buffers and postfixation procedures were tested as well as variations in fixative osmolarity ph and temperature of the commonly used initial fixatives ... | 44|48|83 | acrolein|alone|erythrocyte |
a T0 was carried out to determine the oxyhemoglobin dissociation curve of stromafree hemoglobin solution and AF which influence it ph dpg to simulate acute volume replacement dilution experiments in vitro were performed employing both hemoglobin solution and RL in whole blood it was determined that stromafree hemoglobi... | 1|16|38|59|92 | study|factors|ringers lactate|change|ringers lactate |
tiny tbs partial thickness noncontact radiant heat burns in guinea pigs resulted within hours in significant edema formation and protein leakage at the site of the injury areas of skin distant to the burn also showed an increase in water content but no protein leakage i.c.v. of the animals with either chlorisondamine h... | 45|95|121 | pretreatment|vascular|catecholamines |
the location of td phageinduced DHF reductase dfr has been determined in IN and incomplete phage particles it has been found that phage mutants inducing a temperaturesensitive dfr dfrts procude heatlabile phage particles the structural dfr produced by these ts mutants was shown to assume different configurations depend... | 5|12|76|94|188 | dihydrofolate|intact|binding|dinucleotide|large |
purified c perfringens type a enterotoxin fed orally in an amount of mg caused both vomiting and diarrhea in the monkey only when the gastric juice had been neutralized exposure of enterotoxin to ph or below rapidly destroyed the activity all three monkeys receiving sodium bicarbonate and x viable cells grown in ds med... | 107 | hemagglutination |
the effect of lasting peripheral counterpulsation upon the haemodynamics and the main PSA factors of the blood was studied in dogs with IN hearts in cases of significant ART counterpulsation in a regimen results in only a partial reduction of the resistance to the cardiac output this does not always permit to prevent t... | 12|22|28 | biochemical|intact|tachycardia |
in acute experiments on cats anesthetized with urethane and kept under controlled respiration the mechanism of tonic activity of the pulmonary vessels was studied in the presence of a decreased partial pressure of oxygen in the alveoli the tonicity of the pulmonary vessels was recorded during autoperfusion of the vesse... | 89|162 | study|completely |
using deaecellulose chromatography and agarose gel filtration we have partially purified a low km cyclic adenosine monophosphate amp phosphodiesterase from the x g supernatant of rat kidneys the characteristics of this enzyme included a km of approximately mum a ph optimum of around and a requirement for magnesium this... | 87 | nucleotide phosphodiesterase |
the influence of aging on the RAA system was evaluated by comparing young to yr with elderly to yr healthy subjects despite comparable body sodiumfluid balance in the two age groups serum renin concentration plasma renin activity and aldosterone concentrations were lower in the elderly the agerelated decreases in circu... | 6|85|106 | reninangiotensinaldosterone|study|levels |
there is both clinical and experimental evidence that cellular and humoral immunity are suppressed in patients with renal insufficiency observations in organ transplantation and in vitro stimulation of lymphocytes from uraemic patients investigations of acute and late hypersensitivity reactions the immune response T3 a... | 42|86 | after|serum |
a new method for the measurement of renin in human plasma is described the method is based on the introduction of the internationally available renin standard of the MRC mrc london as a calibration system thus some principal disadvantages of methods expressing results in renin reaction velocity angiotensin generation r... | 28 | medical research council |
ph measurements in blood or in media containing either proteins or polypeptides and performed by means of micro ph combination electrodes type n schott gen mainz yield in a systematic error according to the regression L1 y chi in the range between ph and this deviation from the real ph value is independent of the prote... | 35|121 | line|diffusion |
substantial and prolonged withdrawal hyperexcitability in the neural ATP for affective defense was revealed by behavioral and electrophysiological measures in cats exposed to moderate to heavy doses of alcohol for periods ranging from to hours the data are interpreted as indicating a rapid OD of physical dependence on ... | 8|43 | substrate|development |
acid hydrolases and lysosomal membrane properties were studied at various ages in the normal human BB in csf and four BB regions the inferior olive the cerebellar cortex the Cd nucleus and the frontal cortex were thus betagalactosidase betaglucosidase alphamannosidase hexosaminidase and acid phosphatase biochemically q... | 15|20|29|93 | brain|brain|caudate|variation |
the late effects of various immunosuppressive insults on cellmediated immunity in mice were studied in an attempt to assess the role of immune surveillance in the aging process results were obtained using susceptibility to allogeneic RT cell challenge graftversushost reaction gvhr blastogenic response to pha a thymus d... | 35|94|160|164|192 | tumor|spleen|groups|physical|study |
lipoxygenase was isolated and partially purified from peanut seed by ammonium sulfate precipitation GF and ion exchange column chromatography three isozymes of lipoxygenase were identified two had ph optima of and the other an optimum of molecular weight of each isozyme was x as determined by gel filtration the alkalin... | 13 | gel filtration |
reported is on satisfactory results obtained with a smallsize computer consisting of punching and scanning device as well as plain writing machine in the respiratory CF laboratory developed in on as well as offline processing by an own technical staff a diagnostic and teaching program was established for all respirator... | 25|82|139 | function|evaluation|oxygen pressure |
hydrocortisone hemisuccinate within hours after in vivo administration produced an increase in precursor incoporation into rat thymus rna and proteins in the whole animal from these results together with information obtained from measurements of the TAT activity and the action of mitomycin c po one hour before the inje... | 35|43 | tyrosine aminotransferase|administered |
experiments were carried out to define the kinetic parameters of the L1 phosphate transport processes of RLM and to obtain information about the molecular properties of these systems | 11|16 | major|rat liver mitochondria |
inhibition of acid secretion by an hreceptor antagonist metiamide was assessed in three patients with the zollingerellison syndrome metiamide or mg inhibited acid secretion transiently hours by to per cent in all patients although anticholinergic drugs alone inhibited acid secretion by only to per cent in these patient... | 99|122 | total gastrectomy|zollingerellison |
histamine has a dual action on the isolated perfused ear preparation of the rb the amine induced a dosedependent rise in perfusion pressure when the preparation was perfused with krebs solution this pressor response was reversed to a depressor effect when meypramine was added to the perfusion fluid this depressor effec... | 13|100 | rabbit|rabbit |
the rabbit pulmonary artery contains postsynaptic alphaadrenoceptors which meidate smooth muscle contraction its NE nerves contain presynaptic alphaadrenoceptors which mediate inhibition of the release of the transmitter evoked by nerve impulses DRCs for the pre and postsynaptic effects of eight alphareceptor agonists ... | 13|31|66|129|181|189 | noradrenergic|doseresponse curves|maximal contraction|tritium|doseresponse|right |
inhibiting activity of blood serum was determined from the decrease of nacetylhexosamine end groups of hyaluronic acid products released by testicular hyaluronidase maximum inhibition was observed within the region of ph from to rho between the serum concentration and its inhibiting effect on hyaluronidase was found wi... | 33|54 | correlation|serum |
to determine the effect of changing concentrations of uremic metabolites on factors affecting oxygen transport without the effects of extracorporeal blood pumping we studied five patients before during and after peritoneal dialysis significant decreases in serum urea creatinine and phosphate and increase in SS bicarbon... | 43|58|121 | serum|erythrocyte|tissue oxygenation |
nhcl was infused into the left renal artery of anesthetized dogs at mumkgmin for up to min renal blood flow declined early then increased to supracontrol levels during infusion kidneys perfused at mumkgmin for min showed patchy to confluent mixtures of cortical necrosis and tubular CN experimental kidneys invariably sh... | 45|54|69|116 | necrosis|contralateral|artery|necrosis |
the plasmaionized calcium C2 decreased during haemodialysis when a dialysate calcium concentration of mg ml was used when dialysis was performed with a bath calcium concentration of mg ml there was a significant increase in the plasmionized calcium levels in the postdialysis period these results are discussed in relati... | 3 | levels |
from the chemical and pharmalogical point of view it is impossible to separate strictly between antiepileptic and psychopharmalogical drugs inspite of that and several clinical overlappings it is possible and helpful finding differences between the two CG of drugs basing on the indication we try to demonstrate the use ... | 36 | groups |
soluble glycoproteins have been purified from a series of clones of trypanosoma brucei each clone yielded a characteristic predominant glycoprotein which induced clonespecific immunity to trypanosome infection in mice these glycoproteins were shown by specific labelling and enzyme digestion of cells to be the major com... | 74|82|114|116 | amino acid|large|surface glycoprotein|preparations |
administration of cortisol to fetal rabbits resulted in a inhibition of pulmonary de novo fatty acid synthesis from acetyl coenzyme a coa p less than this was associated with inhibition of acetylcoa carboxylase ec activity p less than and a tendency towards decreased activity of FAS there was no effect on pulmonary mic... | 45|53|56|92|96|130|142|152|163|176|188 | fatty acid synthetase|fatty acid|light|fatty acid synthetase|rabbit|fatty acid|after|acid synthesis|fatty acid synthetase|fatty acid|inhibitory |
atpase activity of myosin in the heart muscle of the mouse rat guineapig rabbit and pig was studied at neutral ph and under mild alkaline conditions at neutral ph the atpase activity of S1 is inversely related to body size of the animal species the decrease of atpase activity of myosin T3 alkaline preincubation depends... | 33|51|65|68|100|113 | myosin|after|myosin|heart|heart|myosin |
the responsiveness of the medullary chemoreceptors measured by the ventilatory response to hypercapnia given in an hyperoxic gas mixture in IN anesthetized dogs has been evaluated during normothermia and at two levels of hypothermia the response was studied in dogs during normothermia of these dogs at a blood temperatu... | 20|63|82|85|118 | intact|ventilatory|normothermia|levels|respiratory drive |
metiamide an histamine hreceptors antagonist has been used to treat a case of zollingerellison syndrome characterized by a long standing diarrhea an important gastric hypersecretion and a moderatly elevated plasma gastrin but without digestive ulceration at the dose of mg per day metiamide induced a complete suppressio... | 69|78 | laparotomy|metastatic |
frequency of exerciseinduced asthma has been studied in unselected asthmatic patients adults and children by measuring the forced expiratory volume at one second fev and the vital capacity vc before and T3 a treadmill exercise continued until HR rate was at least equal to pcent pcent of maximum HR rate in subjects pcen... | 31|37|48|71|87|91|142 | after|heart|heart|bronchial obstruction|exerciseinduced asthma|correlation|variable |
the authors report cases of shock type anaphylactic reactions after the ingestion of glafenine up to the present acute TIN had chiefly been reported the existence of allergy to this medication remains to be proved by the wider application of allergological studies | 19 | tubulointerstitial nephritis |
a doubleblind study comparing betamethasone valerate and placebo aerosols was carried out in patients with a history of SAR and positive skin tests to grass pollens analysis of the symptoms recorded on a daily record card for a period of one month indicated that the mean monthly symptomscore was lower for all PS in the... | 18|52|78 | seasonal allergic rhinitis|symptoms|placebo |
urinary acid excretion was measured in human renal allograft recipients during the first few days T3 the onset of diuresis and two months after transplantation in out of AAR episodes an early significant decrease of renal total net h excretion was observed this urinary acidification impairment preceded the SS creatinin... | 15|28|48|83 | after|rejection|serum|rejection |
adding urine to a standard buffered fibrinogen solution and then coagulating it with thrombin gives reproducible coagulation times with normal urines coagulation of fibrinogen by thrombin is prolonged in acid solutions with a ph below six urines of high acidity lower the buffer ph of the fibrinogen solution below a val... | 98|104 | symptoms|serum |
the lightinduced absorbance change at nm of isolated chloroplasts consists of a rapid phase and a slow phase which is complete in about sec the slow component of the nm absorbance change correlates with the lightinduced NC in degrees light scattering at nm both show a similar time course similar ph dependence with a ma... | 36 | change |
ammonium sulfate fractionation of crude extracts of e coli yields a soluble enzyme fraction about fold purification that catalyzes the conversion of phix ssDNA to duplex dna the reaction is rifampicinresistant requires ssDNA mg deoxynucleoside triphosphates and atp and is stimulated by kcl such soluble enzyme fractions... | 23|32 | singlestranded dna|singlestranded dna |
the intensely chromophoric intramolecular coordination complex formed between arsanilazotyrosine and the active site zinc atom of azocarboxypeptidase a johansen j t vallee b l proc nat acad sci usa is a spectrokinetic probe of catalytic events the interconversion of the azotyrzn complex and its constituents is measured... | 93|166 | binding|carboxypeptidase |
addition of ubiquinone to e coli ml membrane vesicles dramatically increases coupling between nadh oxidation and active transport such that initial rates and steadystate levels of lactose and aminoacid accumulation are comparable to those observed during dlactate oxidation similar but less dramatic effects are observed... | 115|162|170 | nadh dehydrogenase|vesicles|specific |
T3 lethal irradiation longlived immunologically vigorous chf mice were produced by treatment with syngeneic FL cells or syngeneic P0 or AD spleen cells treatment of lethally irradiated mice with syngeneic or allogeneic P0 thymus cells or allogeneic newborn or AD spleen cells regularly led to fatal secondary disease or ... | 0|14|18|20|32|39|285 | after|fetal liver|newborn|adult|newborn|adult|malignancies |
during penicillin treatment of an autolysin defective mutant pneumococcus we have observed three novel phenomena i growth of the mutant cultures is inhibited by the same concentrations of penicillin that induce lysis in the wild type ii mutant bacteria treated with the minimum growth inhibitory concentration of penicil... | 58|99 | growth medium|alone |
euglena gracilis contains a protein system which can utilize the reducing power of nadph in the ribonucleotide reductasecatalyzed reduction of ctp the proteins required for this reaction are a flavoprotien with a molecular weight of approximately which is functionally similar to thioredoxin reductase nadph ec and anoth... | 48 | protein i |
human umbilical HCS was found to contain both free folate and folate complexed to a highmolecular weight factor the complexed folate was bound to a very high affinity binder and was present in concentrations equivalent to as much as ng of methyltetrahydrofolic acid per ml of serum acidification of the serum caused disa... | 2|65|69|78|95|173 | cord serum|gel filtration|sucrose|binding factor|binding|serum folate |
the red azotyrzn complex of arnilazocarboxypeptidase previously used to demonstrate differences in conformation of the enzyme in crystals and in solution has now provided means to detect multiple conformations of the enzyme in solution by stoppedflow ph and temperature jump experiments these studies identify two distin... | 233|303 | carboxypeptidase|carboxypeptidase |
norepinephrine and the enzymes involved in its synthesis and Kd were found to be associated with isolated BB microvessels the significance of these results are discussed with respect to adrenergic innervation of the cerebral microvessels and thereby neural regulation of the cerebral MC | 9|17|42 | degradation|brain|microcirculation |
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