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edelfosine ooctadecylomethylracglycerophosphocholine etoch a membranetargeting anticancer ether lipid drug has been shown previously in vitro to be capable of initiating oxidative processes in cells here we study two human leukemia cell lines hl and k that have different sensitivities to edelfosine hl cells are more se... | 62|69|89|109|212|257|260 | stress|stress|sensitive|sensitive|trypan blue|cell membrane|propidium iodide |
we surveyed five human hematopoietic cell lines hsb molt reh cem and hl to determine whether any simple correlates with sensitivity to killing by gammairradiation might be revealed the clonogenic survival gammaray DRCs for these cell lines cover a wide range of sensitivities consistent with previous results for murine ... | 32|117|138 | doseresponse curves|functioning|cell cycle |
recombinant humanized antiher antibody rhumab her inhibits the growth of breast cancer cells overexpressing her and has clinical activity we explored in preclinical models its capacity to enhance the tumoricidal effects of paclitaxel and doxorubicin in cultures of naturally heroverexpressing cancer cells rhumab her inh... | 113|121 | tumor|complete |
the mechanism by which Th1 inhibits tumor cell growth has not been fully understood here we report that ifngamma upregulated the expression of fas and gld fasl on ht cells a human colon adenocarcinoma cell L1 and subsequently induced apoptosis of these cells the kinetics of cell death in ifngammatreated ht cells parall... | 4|25|35|57|116 | ifngamma|fas ligand|line|levels|ifngamma |
to reinforce cytotoxic activity and the targeting ability of lymphokineactivated killer cells with a tcell phenotype tlak for adoptive immunotherapy against human bile duct carcinoma bdc staphylococcal enterotoxin a sea was conjugated chemically with muse monoclonal antibody muse mab directed to the muc antigen using n... | 69|70|113|142|160 | tumor|neutralization|tumor|administered|adoptive immunotherapy |
after years of clinical trials in patients with advanced cancer monoclonal antibodies mabs against cell surface antigens have not lived up to their initial promise one such cell surface antigen is the ganglioside gd gd is richly expressed at the cell surfaces of human neuroblastomas sarcomas and melanomas we have descr... | 104|117|177|215 | administered|model|after|cell surface antigens |
xeroderma pigmentosum xp patients are hypersensitive to sunlight and have a high predisposition to developing cancer at the cellular level xp patients are defective in nucleotide excision repair ner recently mice have been generated via gene targeting that are deficient in the expression of the xpa gene a de vries et a... | 141|152 | benzoapyrene|early onset |
we have observed a reproducible mitochondrial mutational spectrum in the mt human lymphoblastoid L1 treated with nmethylnnitronnitrosoguanidine mnng the mnng spectrum was distinct from the spontaneous mutational spectrum however our ability to observe mnnginduced mitochondrial mutations above the high level of accumula... | 13|185 | line|transitions |
interleukin il serves as a growth factor for mouse plasmacytomas as a MM for ilmediated growth of plasmacytomas we study ildependent bcell hybridomas which can be generated through fusion of b lymphocytes with a plasmacytoma cell line eg sp in the present report we have investigated the peculiar SMB of bcell hybridomas... | 12|48|79|110|199 | model|behavior|fusion|specific|human chromosome |
we have previously defined depressed mitochondrial function as a determinant in colon cancer risk and progression and established that metabolism of butyrate a shortchain fatty acid generated during the fermentation of fiber by endogenous intestinal bacteria induces mitochondrial functiondependent growth arrest and apo... | 132 | colonic |
invasive lobular carcinoma comprises approximately of human mammary cancers yet little is known about the molecular basis of this carcinoma because cyclin d plays a role in the pathogenesis of breast carcinomas of the ductal type we hypothesized that this confirmed oncogene might also participate in the OD of lobular c... | 47|63|88|90|106|152|241|262|289 | development|invasive lobular carcinoma|cell cycle|study|staining|southern blotting|cancer|correlation|subtype |
the glycosyltransferase termed glcnactiii is dedicated to the transfer of a single nacetylglucosamine glcnac residue the bisecting glcnac to a subset of nglycans in glycoproteins the addition of this glcnac is differentially regulated during OD and is induced in certain cancers particularly in hepatic tumorigenesis to ... | 34|58|84|128|171|186|211|213|230 | development|liver|after|tumors|tumor|tumor|gene expression|tumor|tumor |
expression of mutated versions of the p gene deranged the differentiation program of thyroid cells and resulted in deregulated growth specifically p mutants in several residues of the dnabinding region induced thyrotropin tsh independent growth and inhibition of the expression of thyroidspecific genes the loss of the d... | 168 | sensitive |
prostate cancer is the most common solid RT in american men and is the second most common cause of cancer deaths although surgery and radiation therapy are effective for the treatment of organconfined CA there is no effective treatment that is currently available for patients who have metastatic disease antiandrogen th... | 7|33|72|84|122|132 | tumor|cancer|cancer|cancer|cancer|study |
in order to elucidate whether urinary C2 of inorganic and organic As metabolites are associated with previous exposure to higharsenic artesian well water a total of residents of age yr or older were recruited from three arseniasishyperendemic villages in taiwan most study subjects had stopped consuming higharsenic arte... | 6|11|84|127|128|141|155 | levels|arsenic|multivariate analysis|arsenic|exposure|levels|multivariate analysis |
metallothioneins mt are ubiquitous lowmolecularweight proteins that exhibit high binding affinities for heavy metal ions the expression of these CR proteins is induced in response to various types of chemical and PCS stresses and therefore can be used to assess human SE to cytotoxic environmental agents in the current ... | 19|31|41|55|63 | cysteinerich|physical|exposure|blood lymphocytes|flow cytometry |
the use of pesticides in agriculture has increased over the last decade their widespread often uncontrolled use causes thousands of people to be daily exposed to environmental agricultural chemicals resulting in acute and chronic health effects at present there is a paucity of data on the potential adverse effects of e... | 67|95 | exposure|experimental |
prolonged hyperglycemia results in a number of diabetic complications including retinopathy pericyte degeneration is one of the earliest histological changes observed in the development of diabetic retinopathy increased FRs generated under hyperglycemia could damage the retina which abounds in polyunsaturated fatty aci... | 28|101|156 | free radicals|hyperglycemia|diabetic retinopathy |
kashinbeck disease kbd an endemic chronic osteoarthritic disorder with necrosis of chondrocytes commonly occurs in china the humic substance present in the drinking water of endemic areas has been proposed as one of the causative AF in this study an in vitro CC system was used to investigate the damaging effects of SHA... | 35|42|52|61|168|169|182 | factors|cell culture|humic acid|rabbit|chemiluminescence|assay|chemiluminescence |
the biochemical effects of hydrogen sulfide were investigated by treating enzyme homogenates and synaptosomes prepared from rat brain with sodium sulfide brain cytochrome c oxidase activity was highly sensitive to inhibition by sodium sulfide as demonstrated by an ic of microm sodium sulfide was also found to inhibit c... | 16|177 | mammalian|brain |
to evaluate the role of cytopathology and its different sampling techniques in the diagnosis of wegeners granulomatosis we retrospectively reviewed cytologic specimens from patients with an established diagnosis of wegeners granulomatosis the smear background cellular composition and accompanying reactive changes were ... | 139 | pattern |
loss of p and pwaf expression have previously been reported in pancreatic adenocarcinoma despite these findings in several reports of oncogene and RT suppressor gene alterations in pancreatic cancer the clinical significance of these changes is still poorly understood in an attempt to detect molecular prognostic marker... | 22|48|170|217|235 | tumor|pancreatic carcinoma|correlation|tumor|tumors |
ki is a proliferation marker that is often used to estimate the growth fraction of PT and other tissues this antigen is expressed during all phases of the cell cycle but not in quiescent g cells many studies fail to indicate that the ki antigen can be expressed even when dna synthesis is blocked we studied the expressi... | 15 | tumors |
we sought to determine the sensitivity and specificity of immunohistochemistry using the tordji moab biogenex san ramon calif which is specific for the c protein of the HC virus compared with reverse transcriptasepolymerase chain reaction rtpcr of tissue for viral rna rtpcr had been performed on fixed tissue specimens ... | 27|57|86|135|139 | hepatitis c|alkaline|hepatocytes|hepatitis c|liver |
the gross features of prostatic adenocarcinoma can be subtle while these gross features have been described the histologic correlates have not been detailed this T0 involved examination of consecutive RP specimens between january and december the gross findings were correlated with histologic examination no gross lesio... | 24|29|64|95|160|200 | study|radical prostatectomy|tumor|tumors|tumor|extraprostatic extension |
routine diagnosis of pathology images transmitted over telecommunications lines remains an elusive goal part of the resistance stems from the difficulty of enabling image selection by the remote pathologist to address this problem a telepathology microscope system telepath telemedicine solutions birmingham ala that has... | 141|166 | reference|reference |
to study the comparative value of the levels of cardiac troponin i ctni creatine kinasemb isoenzyme ckmb and myoglobin in the detection of acute ischemic myocardial injury we serially measured plasma concentrations of these cardiac proteins in pigs with myocardial ischemia subtending severe PD stenoses and in pigs with... | 43|55|63|92|116|145|195|206 | coronary artery|coronary artery stenosis|left anterior descending|ventricular|abnormalities|development|levels|ischemic |
the microparticle enzyme immunoassay meia for digoxin abbott laboratories abbott park ill requires no sample i.c.v. and is widely used in clinical toxicology laboratories for monitoring serum digoxin concentrations one advantage of the new meia is the lower crossreactivities with such crossreactants as digitoxin oleand... | 15|50|125|164 | pretreatment|fluorescence polarization immunoassay|serum|binding |
serial bone marrow aspirates from patients previously given a diagnosis of acute lymphoblastic leukemia all who had undergone chemotherapy bone marrow transplantation bmt or both were analyzed by multidimensional flow cytometry mdf to detect residual disease lower limit of detection correlation between the results of m... | 198 | early intervention |
patients with wiskottaldrich syndrome a severe inherited immunodeficiency disorder have a markedly increased risk of developing nonhodgkins lymphoma compared with the general population these are uniformly diffuse aggressive bcell neoplasms that resemble those seen in aids and the posttransplantation setting and also m... | 82|94|112 | light|tumor|tumor |
autologous blood donation before elective surgery is generally believed to be a safe procedure for patients with a variety of underlying medical conditions but the accumulation of additional data continues to define its safety in unique patient groups patients who have received a solid organ transplant may also undergo... | 105 | liver |
whether it is necessary to adjust the citrate volume in blood collection tubes for patients with anemia is unknown however the standard of care is not to adjust the volume we compared the prothrombin time pt and activated PTT time aptt test results of nonadjusted and adjusted citrate amounts in specimens from patients ... | 38|91 | partial thromboplastin|correlation |
the use of reconstructed human epidermis provided the basis for an in vitro MM of human cutaneous candidosis candida albicans blastospores on the surface of reconstructed human epidermis provoked the following changes within h SF keratin degradation scaling hyperkeratosis parakeratosis dyskeratosis representing hyperpr... | 13|34|43|73|89|93|151|176 | model|superficial|stress|stratum corneum|after|pretreatment|after|model |
conventional methods for the diagnosis of mycobacterium tuberculosis infections have serious limitations to determine whether amplification of m tuberculosis dna in serum by the polymerase chain reaction pcr might be a useful additional diagnostic tool we tested clinical specimens using primers TPS for the is insertion... | 41|59|103 | specific|healthy controls|infected |
CDAD cdad is primarily a nosocomial condition communityacquired disease has been reported but the incidence is felt to be low and the rate of disease resulting in hospitalization is reported as negligible we recently experienced a month outbreak of cdad january to june patients were involved and four deaths were attrib... | 0 | clostridium difficileassociated disease |
a large singlesource salmonella outbreak caused by a rare serovar bovismorbificans r occurred in southern finland in the origin of the outbreak was sprouted alfalfa seeds a questionnaire was mailed to all subjects with positive stool SC ninetyone percent returned the questionnaire one hundred and fiftythree were adults... | 36|65|125|128|158|195 | culture|symptoms|symptoms|symptoms|tissue type|symptoms |
although neurological symptoms in brucellosis are frequent central nervous system cns involvement is uncommon five patients with neurobrucellosis are presented three patients presented with meningoencephalitis one with polyradiculoneuritis and one with myelitis and an eighth nerve palsy all patients had lymphocytic ple... | 43|71 | glucose|serum |
the diagnosis and treatment of pneumonia in mass gathering situations is a medical challenge requiring prompt decision making and knowledge of the aetiology we studied cases of pneumonia admitted to two hospitals during the pilgrimage hajj season to makkah sixtyfour patients were enrolled in the T0 of which were men wi... | 45|129 | study|tuberculous |
the rate of cd tlymphocyte decline seen in hivinfected patients is very VL although older patients a longer duration of hiv infection and a high level of plasma viraemia have been associated with a faster fall in cd tcells the relationship between these variables is still not well known | 12 | variable |
we reviewed the clinical record of all patients admitted to saga medical school hospital during the most recent years and found that were diagnosed as having necrotizing fasciitis bacteriological examination demonstrated that vibrio vulnificus was the pathogen responsible in five patients the disease caused by v vulnif... | 100|134|147 | systemic|bleeding|systemic |
the objective of the study was to obtain detailed descriptive epidemiological information on sporadic verocytotoxinproducing escherichia coli o infection in scotland in relation to transmission routes and hostrelated risk AF using a standardized questionnaire the study was carried out throughout scotland over an month ... | 29|79|96 | factors|study|factors |
a hivpositive patient presented with CM that was not detected by cerebrospinal fluid csf latex antigen and direct microscopy the diagnosis was confirmed by culture of the csf and subsequent urine culture both of which yielded an apparently acapsular strain of cryptococcus neoformans T3 months the patient relapsed and c... | 5|43|69|77 | cryptococcal meningitis|after|culture|culture |
ecthyma gangrenosum is a characteristic skin lesion that is caused by pseudomonas aeruginosa p aeruginosa in the majority of cases systemic p aeruginosa usually complicates debilitating conditions like leukaemia burns and cystic fibrosis we report a patient with underlying hypogammaglobulinemia who developed ecthyma ga... | 63 | appropriate |
burkholderia pseudomallei is an important human pathogen in tropical Az particularly south east asia and RNA australia a fatal case of meliodosis presenting as BB abscesses is described the patient deteriorated despite treatment and died days after admission burkholderia pseudomallei was only isolated after administrat... | 9|15|24|103 | areas|northern|brain|areas |
amoebic CL abscesses ala are characteristically large lesions at presentation but their OD in man has not previously been described we present a case of an ala that over the course of days developed from an undetectable lesion to a cm diameter lesion this clinical history suggests that the pathogenesis of alas may purs... | 1|12 | liver|development |
we report a case of postanginal septicaemia complicated by bronchopneumonia and haemophagocytosis in a year old male presenting with severe thrombocytopenia we believe that this is the first reported case of TP due to haemophagocytosis in this unusual condition | 31 | thrombocytopenia |
we describe a yearold male who developed native valve infective endocarditis due to staphylococcus capitis as a consequence of repeated oesophageal dilatation the patient was treated with AGA antibiotic therapy but his condition deteriorated and he died we review previously reported cases of IE associated with upper en... | 27|43 | appropriate|infective endocarditis |
HIVE associated with dengue fever is considered to be a rare condition in adults we describe a patient with a primary dengue infection who in the absence of overt signs of dengue shock syndrome died due to progressive cerebral oedema autopsy findings demonstrated loss of integrity of CBF V1 endothelium and involvement ... | 0|47|48 | encephalopathy|cerebral|vascular |
congenital ataxias ca are rare predominantly nonprogressive syndromes characterized by marked hypotonia developmental delay followed by the appearance of ataxia most children show marked speech and cognitive developmental problems non progressive ca npca can be divided into pure ca without additional symptoms and syndr... | 101|132|135 | cytomegalovirus infection|history|clinical examination |
tuberous sclerosis is a heredofamilial neurocutaneous syndrome or phakomatosis with multisystem involvement including the brain kidney skin retina heart lung and bone the brain is the most frequently affected organ in tuberous sclerosis brain lesions in tuberous sclerosis are of three kinds cortical tubers VWM abnormal... | 44|82|110|116 | white matter|white|proton density|relaxation |
the anticonvulsant action of felbamate and mgkg ip was tested against motor seizures induced by pentylenetetrazol in five agegroups of rats and days old in AD rats felbamate suppressed GTC seizures leaving intact minimal clonic seizures in all groups of rat pups FBM exhibited a specific action against the tonic phase o... | 25|29|42|52 | adult|generalized tonicclonic|felbamate|generalized tonicclonic |
in this paper the results of an extensive medical investigation of children with childhood autism are presented and compared with those found in a group of nonautistic individuals matched for sex age and intellectual level all referred for developmental deviancy of unknown etiology the examination included a psychiatri... | 114 | groups |
to investigate maturational change in the susceptibility of voltagedependent calcium ca channels vdcc in the BB to excessive depolarization which is likely to occur during hypoxia or ischemia we studied depolarizationinduced increases in ca concentration in cortical synaptosomes cai obtained from young and dayold and a... | 15|161|184|205|230 | brain|ca channels|adult|adult|after |
we describe a boy who has gelastic epilepsy precocious puberty hypothalamic hamartoma and agenesis of the corpus callosum we believe that this is the first documented case in which agenesis of the CC has been associated with Thy hamartoma and gelastic epileptic syndrome in a child | 32|37 | corpus callosum|hypothalamic |
we report the youngest known case with balós con sclerosis balós disease a variant of multiple sclerosis this yearold japanese boy was diagnosed by clinical manifestations and by characteristic findings on magnetic resonance imaging mri dexamethasone was given intravenously mg twice daily for days the clinical manife... | 8|58|71 | concentric|after|physical |
the authors describe a case of early ON ataxia with CA and VE deficiency treated with alphatocopherol supplementation and physically rehabilitated by postural biofeedback clinical assessments SS VE levels and postural evaluation by means of a stabilometric platform continued for about years and significant clinical imp... | 7|10|12|26|27|53|73|87 | onset|cerebellar atrophy|vitamin e|serum|vitamin e|physical therapy|serum|brain |
AD male rats were fed one of five diets varying in fat composition purina chow or soy bean oil CO MO or olive oil added to chow for weeks T3 days of access no differences between CG were found in CS measured at light ON and light offset during week restraint stress tests were performed highfat diets promoted significan... | 0|19|20|29|36|40|44|86|89|140|177|191 | adult|corn oil|menhaden oil|after|groups|plasma corticosterone|onset|glucose|glucose|corn oil|stress|feeding |
five thousand and eighteen quadruplet daily measurements of lowerleg length of female and male rats were performed in order to characterize shortterm growth within a short time growth proceeds irregularly and consists of multiple incremental bursts mini growth spurts with no evidence for strict periodic behavior mini g... | 84|209 | slope|variation |
endogenous analgesia induced by changes in motivation has been identified in the chicken in previous studies but either the motivational changes were difficult to interpret or the motivation was unpredictable experimental sodium urate su ICA of the ankle joint resulted in paincoping behaviour onelegged standing or sitt... | 34|81|97 | arthritis|injection|intravenous injection |
senescenceaccelerated mice sam p and r were behaviorally assessed in a crosssectional T0 at and months of age behavioral measures included memory place discrimination and repeated acquisition in a WM sensorimotor performance turning in an alley traversing bridges wire rod hanging and falls from a wire screen psychomoto... | 12|29|95|161|198 | study|water maze|memory|general|anxietylike behavior |
the relationship between plasma testosterone levels and locomotor activity in wildcaught sexually mature male meadow voles microtus pennsylvanicus was assessed in the laboratory several aspects of locomotor activity were monitored for h on two consecutive days using the automated digiscan activity monitoring system pla... | 45|64 | levels|levels |
a shortterm fluidintake test is described which is directed at the study of individual variation in gustation in laboratory mice to avoid position preferences associated with twobottle tests single graduated cylinders are used to present the solution intake of water and solutions is recorded for a h period beginning h ... | 57|132|149 | light|glutamate|cblj |
both longevans le and wistarfurth wf strains of rat are known to be resistant to development of hypertension by mineralocorticoid mc treatment mcinduced hypertension is in part mediated by the BB we have examined another aspect of central mc action the induction of nacl appetite in these strains by using the more commo... | 30|158 | brain|adult |
lurcher mutant mice characterized by degeneration of cerebellar purkinje cells and granule cells were compared to normal littermate controls for different facets of grooming and nongrooming behaviors after a brief period of WI by comparison to NCs the number and the duration of several grooming components were decrease... | 32|36|133 | water immersion|normal controls|sequence |
the present study investigated how variations in the period of delay between training and testing in the MWM task affect the use of spatial SM in AD rats that were prenatally exposed to ethanol previous results utilizing the morris water maze task have shown that prenatal or early postnatal SE to ethanol produces defic... | 17|24|26|49|63|109|153|171|180 | morris water maze|memory|adult|exposure|memory|water maze|exposure|exposure|morris water maze |
to investigate the role of the central ACh system in the regulation of metabolism during exercise we injected atropine x mol into the lateral cerebral ventricle of normal and adrenodemedullated adm UT rats submitted to exercise on a treadmill m min grade until exhaustion concentrations of blood glucose plasma free fatt... | 7|31|61|105|135|184|196|197|206|207|235 | cholinergic|untrained|after|glucose|levels|plasma glucose|central|cholinergic|energy|substrate|feedback |
bxsb mpjyaa and nzbbinj mice have been used as animal models for both developmental learning disability and SVR autoimmune disease approximately of these animals show ectopic clusters of SN in layer i of SC similar to those found in postmortem analyses of human dyslexics and all exhibit an autoimmune condition similar ... | 17|28|33|126 | systemic|neurons|cortex|behavior |
we have devised a method behavioral waveform display analysis to analyze complex ethological information by measuring SMB in real time and visualizing it as a timedependent multistate waveform to facilitate the generation and statistical analysis of behavioral waveform displays we have designed a simple macintoshbased ... | 16|197|226|244 | behavior|behavior|onset|onset |
this study investigated the effects of ingestion of a meal compared to a sham feeding on objectively measured sleepiness it was hypothesized that the ingestion of a solid meal would produce significantly greater PP sleepiness evidenced by shorter sleep onset latencies sol when compared to a SF eleven men and eight wome... | 33|46|107|148 | postprandial|sham feeding|polysomnographic|sleep latency |
mice of the cxb RI ri panel were phenotyped for period of locomotor activity in continuous dark tau and in continuous lux light taull there were significant differences in the effect of light on period delta tau taulltau among cxb ri strains and their progenitors by comparing CS means for delta tau in the cxb ri strain... | 4|47 | recombinant inbred|strain |
smoking cessation often results in weight gain but certain subtypes of smokers may be more likely than others to gain weight women high in dietary restraint restrainers increase FI and gain more weight than nonrestrainers during smoking cessation restrainers have also been reported to increase food NI following laborat... | 28|46|110|125|165|238 | food intake|intake|smokers|stress|ad lib|stress |
anterodorsal thalami nuclei adtn exert an inhibitory influence on the hypophysoadrenal system has under basal and acute AS conditions however after chronic stress the effect is different the response to CIS imo forced immobilization for minday for days and variable chronic stress v day exposure to different stressors p... | 17|30|72|91|92|99|124|126|176 | stress|chronic immobilization stress|variable|after|exposure|stress|variable|stress|stress |
the purpose of this study was to examine the effects of ethanol on operant responding in rats drugs may affect response rates by several mechanisms including altering motor performance or sensitivity to reinforcement these two processes can be dissociated by applying a quantitative MM of reinforced responding the respo... | 43 | model |
most histories of senile dementia commence with alois alzheimers description in of the first case of alzheimers disease yet the history of senile dementia before is quite rich dating back to the ancient greek and roman philosophers and physicians over the years since ancient times the concept of senile PSD has evolved ... | 49|88|94|107|133 | dementia|history|behavior|dementia|dementia |
increased cytokinemediated cytotoxic A-NK nk cell activity has recently been demonstrated in patients with senile dementia of the alzheimers type sdat in the present study we evaluated whether proteinkinase c pkc a main regulatory enzyme involved in the mechanism of exocytosis by nk cells has a role in the cytotoxic re... | 3|58|172 | natural killer|exposure|after |
alzheimers disease ad brains display intense microglial immunoreactivity in the area of senile plaques suggesting that amyloid betaprotein may stimulate microglial infiltration the activated microglia may modulate an immune response in the brain nonsteroidal antiinflammatory drugs nsaids are candidate therapeutics for ... | 99|160 | staining|effective |
the frequency of autoantibodies aabs was surveyed in several neurodegenerative diseases other neurological diseases and controls using antigenspecific eias for NF-M heavy subunit tubulin glial fibrillary acidic protein s protein tau betaamyloid peptide myelin basic protein and heparan sulfate proteoglycan HF of sera an... | 20|40|74|75|100|117|150 | neurofilament|high frequencies|vascular|dementia|dementia|groups|study |
aged monthold male LE were assessed for deficits in spatial cognition relative to young monthold rats an in vitro autoradiography T0 was then conducted for muscarinic m sites using hafdx to assess binding in basal forebrain and brainstem areas where ACh neurons are localized the analysis of basal forebrain included the... | 3|20|40|90|111 | longevans rats|study|cholinergic|brainstem|cholinergic |
the effect of age on pilocarpineinduced expression of the immediateearly gene cfos was examined in the hippocampus and SC of longevans rats rats were treated with either pilocarpine mgkg or saline and sacrificed min following i.t. the level of cfos mrna and foslike protein expression was determined using in situ hybrid... | 18|35|59|108|168 | cortex|injection|levels|cortex|muscarinic receptors |
groups of old and young rats were administered three tests of spatial learning and memory that are known to be sensitive to HPC dysfunction the RAM ram spatial nonmatchingtosample snmts and a spatial vs local cuepreference task old rats performed worse than young rats on the ram and snmts tasks on the cuepreference tas... | 22|25|92|148|152|158 | hippocampal|radial arm maze|glucose|memory|hippocampal|glucose |
the effects of aging on acoustic and airpuff startle CR acoustic and airpuff startle habituation acoustic and crossmodal lightacoustic prepulse inhibition ppi and FPS fps were examined using y young ad adult ma middleaged and o old monthold fischer f rats ad rats had the highest acoustic startle reactivity with the y a... | 9|23|60|148 | reactivity|fearpotentiated startle|levels|reactivity |
calciumbinding proteins play potentially important roles in neurogenesis and neuroprotective mechanisms some evidence exists that brain calbindindk calb is regulated by androgens in the present study calretinin calret and calb patterns were determined by western analysis in the medial basal hypothalamus mbh from male r... | 52|55|71|158 | postnatal|levels|peak levels|brain |
in this study we tested the hypothesis that the efficacy of lglutamate to stimulate hmk binding to the nmda receptorchannel complex is altered as a CF of aging lglutamate or related excitatory CAA eaa is the endogenous neurotransmitter of the nmda receptorchannel complex these studies examined the efficacy and potency ... | 25|32|61|70|107|164 | function|amino acid|binding|doseresponse|cortex|brain |
crosssectional studies on adult human autopsy material have shown that younger cohorts have heavier brains than older groups we sought to determine whether a similar pattern is present in the rhesus monkey a species that serves as a useful model of human brain and cognitive aging data were obtained from necropsies of r... | 79|150|156 | heart weight|brain|linear regression |
we determined whether FR or the drugs nimodipine ca antagonist and deprenyl a maob inhibitor prevent the OD of stroke in the spontaneously hypertensive strokeprone rat shrsp forty male shrsp rats in the age of weeks were exposed to various treatments during a period of weeks survival and blood pressure were followed in... | 3|17|66|88 | food restriction|development|after|study |
rabbits of two age CG young months n and aging months n were implanted with chronic recording electrodes in area ca of dorsal hippocampus and trained in a delay conditioned jaw movement cjm paradigm after previously reaching criterion in a trace cjm paradigm with the same CS stimulus and unconditioned stimulus unlike r... | 4|46|145 | groups|conditioned|hippocampal |
changes in condylar mobility and radiographic changes were examined in patients joints who had nonreducing disk displacement the patients had no treatment for at least one year thirty joints in persons with no current or previous temporomandibular joint PS served as a control the clinical signs and symptoms tended to b... | 38|53 | symptoms|after |
the purpose of this clinical followup study was to evaluate the success rate of autotransplantation of human premolars in the period between and premolars in patients were transplanted a longterm success rate of with a mean followup period of years was achieved it seems to be justified therefore in selected cases to co... | 68 | insertion |
a retrospective T0 was undertaken to analyse the etiology site and treatment procedures of pathological fractures of the mandible fifty percent of the fractures had an inflammatory cause the remaining cases were associated with severe atrophy of edentulous mandibles benign tumours cysts and primary or secondary maligna... | 2 | study |
controversies still exist about the preferred treatment of condylar head and neck fractures newly developed access techniques in combination with new methods to fix the fragments lead to satisfactory results this T0 deals with a refinement of surgical treatment of intracapsular fractures | 31 | study |
ocular signs and symptoms associated with facial trauma can be a manifestation of an underlying psychiatric disorder which may exist prior to the traumatic incident or even develop as a result of the stressful traumatic experience in a psychologically vulnerable individual two such cases are presented a brief review of... | 52|58 | symptoms|evaluation |
a range of environmental and host AF has been identified to explain the etiopathogenesis of squamous cell carcinoma of the lip however the definitive pathogenic pathway remains unclear carcinogenesis does not seem to be limited to a single agent but rather to a complex multistep process of interactions between putative... | 6|61 | factors|factors |
the antitumor effect of photodynamic therapy pdt on mouse tumors was evaluated with bromodeoxyuridine brdu immunohistochemistry brdu was injected into the mice intraperitoneally mgkg body weight immediately after injection of brdu pdt using a photosensitizing drug hematoporphyrin oligomers mgkg body weight was carried ... | 46|112|139|145 | experimental group|experimental group|tumor|normal tissue |
thirtyseven samples of oral mucosa were analysed and divided histologically into groups of NM hyperplastic lesions dysplastic lesions and squamous cell carcinoma all lesions displayed some expression of cerbb but the distribution and intensity of expression varied strongly according to the differentiation the lower the... | 13 | normal mucosa |
a rare case is described of merkel cell carcinoma of the cheek arising in a cutaneous neurofibroma in a patient with recklinghausen NF the relevant literature is reviewed | 22 | neurofibromatosis |
a parosteal CS with lowgrade malignancy attached to the hyoid bone in a yearold man is reported the RT was considered to present a lowgrade malignancy because slight invasion into the surrounding soft tissues and rapid growth were observed four years after initial surgery he had a local recurrence to the best of our kn... | 2|18|63 | chondrosarcoma|tumor|chondrosarcoma |
flow cytometric analysis of cell cycle fractions and dna ploidy was performed on biopsy specimens of oral leukoplakia the aneuploidy rate of these leukoplakias was and the mean DI of the aneuploid lesions was the aneuploidy rate was significantly higher in severely dysplastic lesions than in mildly dysplastic p and non... | 28 | dna index |
salivary calculi are frequently formed in the submandibular duct the most common sites are where the duct turns round the distal edge of the mylohyoid where the duct crosses the lingual nerve and just distal to the duct orifice UT calculi can cause one and glandular atrophy and then may exfoliate through the floor of t... | 39|43 | untreated|obstruction |
a discshaped bone graft was harvested from the calvarium in ten rabbits and anchored as an onlay bone graft using a titanium implant at the PTM the contralateral tibia served as the control where an implant was placed without a graft with the implant head at a height corresponding to the thickness of the graft on the t... | 25 | proximal tibial metaphysis |
the in vitro differentiation of trypanosoma brucei from bloodstream to procyclic insect forms is accompanied by diminishing variant surface glycoprotein vsg and increasing levels of procyclin and phosphoenolpyruvate carboxykinase pepck in this study we examined the fate of several glycolytic enzymes of t brucei during ... | 63|69|213|235|252 | glyceraldehydephosphate|phosphoglucoisomerase|levels|proteases|proteases |
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