Unnamed: 0 int64 0 2.34M | title stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,336,100 | Comparison of the effect of foot reflexology and body massage on physiological indicators and bilirubin levels in neonates under phototherapy. | Hyperbilirubinemia is one of the most common problems in infancy in the world. The aim of this study was to compare the effect of foot therapy and body massage on physiological indicators and bilirubin levels in infants under phototherapy.</AbstractText>This study was a randomized clinical trial that conducted on 51 in... |
2,336,101 | Apelin ameliorated acute heart failure via inhibiting endoplasmic reticulum stress in rabbits. | This study aimed to investigate whether inhibition of endoplasmic reticulum stress (ERS) mediated the ameliorative effect of apelin on acute heart failure (AHF). Rabbit model of AHF was induced by sodium pentobarbital. Cardiac dysfunction and injury were detected in the rabbit models of AHF, including impaired hemodyna... |
2,336,102 | Adjuvant chemotherapy in early-stage endometrioid endometrial cancer with >50% myometrial invasion and negative lymph nodes. | The role of adjuvant chemotherapy as an addition or alternative to radiotherapy for early-stage high-risk endometrioid endometrial cancer is controversial. This study aimed to investigate the role of adjuvant chemotherapy in early-stage high-risk endometrioid endometrial cancer.</AbstractText>We identified patients wit... |
2,336,103 | Anesthetic effect of ultrasound-guided multiple-nerve blockade in modified radical mastectomy in patients with breast cancer. | Routine anesthesia modality for modified radical mastectomy (MRM) includes general anesthesia (GA), epidural blockade-combined GA and nerve blockade-combined GA. However, GA has been associated with postoperative adverse effects such as vertigo, postoperative nausea and vomiting and requirement for postoperative analge... |
2,336,104 | A Randomized Observer-Blinded Controlled Trial to Compare Pre-Emptive with Postoperative Ultrasound-Guided Mandibular Nerve Block for Postoperative Analgesia in Mandibular Fracture Surgeries. | Ultrasound-guided (UG) mandibular nerve block is effective for providing postoperative analgesia in mandibular fracture surgeries. The pre-emptive nerve blockade prolongs the duration of postoperative analgesia and reduces the consumption of intraoperative opioids. The aim of this prospective, randomized, single-blinde... |
2,336,105 | Modulation of human T-type calcium channels by synthetic cannabinoid receptor agonists in vitro. | Consumption of Synthetic Cannabinoid Receptor agonists (SCRAs) is associated with severe adverse reactions including seizures, arrhythmias and death, but the molecular mechanisms surrounding SCRA toxicity are not yet established. These disease-like symptoms are also synonymous with altered T-type calcium channel activi... |
2,336,106 | Case series of late lead dislodgement of Medtronic SelectSecure 3830 pacing leads in growing paediatric patients. | The SelectSecure lumenless 3830 pacing lead is often considered to be the pacing lead of choice for transvenous pacing in children because of its small diameter, lead strength, and reliable long-term sensing and pacing characteristics. One of the potential long-term pitfalls of a sturdy pacing lead is relative retracti... |
2,336,107 | Different acupuncture intervention time-points for improving capacity in motor function and activities of daily living after stroke: A protocol for systematic review and network meta-analysis. | The incidence of stroke has been found in an increasing trend worldwide, resulting in significant negative effects and severe impairments to survivors in terms of motor function and activities of daily living. Acupuncture therapy has been widely used in the clinical treatment of stroke for a long time, meanwhile, the e... |
2,336,108 | Association between physical activity and risk of obstructive sleep apnea. | This aim of this study was to investigate the association of physical activity with OSA risk among adult Chinese.</AbstractText>Participants were selected from baseline survey of the Guangzhou Heart Study. OSA was ascertained by using Berlin Questionnaire, and the physical activity, including leisure-time physical... |
2,336,109 | Anesthetic efficacy of single buccal infiltration of 4% articaine compared to routine inferior alveolar nerve block with 2% lidocaine during bilateral extraction of mandibular primary molars: a randomized controlled trial. | Inferior alveolar nerve block (IANB) using lidocaine 2% is commonly used for anesthetizing primary mandibular molars; however, this technique has the highest level of patient discomfort compared to other local anesthesia techniques. Therefore, alternative anesthesia techniques are necessary. The aim of this study was t... |
2,336,110 | Enhanced endothelial barrier function by monoclonal antibody activation of vascular endothelial cadherin. | Excessive vascular permeability occurs in inflammatory disease processes. Vascular endothelial cadherin (VE-cadherin) is an adhesion protein that controls vascular permeability. We identified monoclonal antibodies (mAbs) to human VE-cadherin that activate cell adhesion and inhibit the increased permeability of endothel... |
2,336,111 | [Comparative study between electroacupuncture at Neima point and Neiguan (PC 6) and epidural nerve block for preemptive analgesia in patients undergoing thoracic surgery]. | <b>目的：</b>比较电针内麻点和内关穴超前镇痛与硬膜外神经阻滞超前镇痛在胸科手术围术期镇&... |
2,336,112 | Pharmacokinetic and Tissue Distribution of Orally Administered Cyclosporine A-Loaded poly(ethylene oxide)-block-Poly(ε-caprolactone) Micelles versus Sandimmune<sup>®</sup> in Rats. | We have previously reported on a polymeric micellar formulation of Cyclosporine A (CyA) based on poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO5K</sub>-b-PCL13K</sub>) capable of changing drug biodistribution and pharmacokinetic profile following intravenous administration. The objective of the present stud... |
2,336,113 | First trimester combined screening test for aneuploidies in anti-Ro carriers pregnant women. | Anti-Ro/SSA and anti-La/SSB antibodies are associated with neonatal lupus and congenital heart block. Controversial results regarding perinatal outcomes are found and less is known about aneuploidy screening. The hypothesis is that the presence of anti-Ro and/or anti-La antibodies influences the levels of PAPP-A and &#... |
2,336,114 | Integrin-directed antibody-based immunotherapy: focus on VLA-4. | One major finding of chronic inflammatory diseases of various origins is the establishment of inflammatory infiltrates, bearing different leukocyte subpopulations, including activated T lymphocytes. Integrins are among the large series of molecular interactions that have been implicated as players in both triggering an... |
2,336,115 | Combined transverse thoracis plane and pectoral nerve blocks for breast surgery under sedation. | The pectoral nerves 2 (pecs 2) block is widely used as adjunct to general anaesthesia for breast surgery. There are a few case reports and a single case series that describe regional anaesthesia as a single technique or supplemented by light to moderate sedation. Here we describe the management of a 91-year-old ASA phy... |
2,336,116 | Unpacking power dynamics in research and evaluation on social accountability for sexual and reproductive health and rights. | Over the past decade, social accountability for health has coalesced into a distinct field of research and practice. Whether explicitly stated or not, changed power relations are at the heart of what social accountability practitioners seek, particularly in the context of sexual and reproductive health. Yet, evaluation... |
2,336,117 | The Impacts of Temporal Variation and Individual Differences in Driver Cognitive Workload on ECG-Based Detection. | This paper aimed to investigate the robustness of driver cognitive workload detection based on electrocardiogram (ECG) when considering temporal variation and individual differences in cognitive workload.</AbstractText>Cognitive workload is a critical component to be monitored for error prevention in human-machine syst... |
2,336,118 | What Therapeutic Regimen Will Be Optimal for Initial Clinical Trials of Pig Organ Transplantation? | We discuss what therapeutic regimen might be acceptable/successful in the first clinical trial of genetically engineered pig kidney or heart transplantation. As regimens based on a calcineurin inhibitor or CTLA4-Ig have proved unsuccessful, the regimen we administer to baboons is based on induction therapy with antithy... |
2,336,119 | Fever as a predictor of adverse outcomes in COVID-19. | <AbstractText Label="BACKGROUND/INTRODUCTION" NlmCategory="BACKGROUND">There are little data on outcomes of COVID-19 patients with the presence of fever compared to the presence of symptoms.</AbstractText>We examined the associations between symptomology, presence of fever and outcomes of a COVID-19 cohort.</AbstractTe... |
2,336,120 | Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion. | Bupivacaine and Levobupivacaine are frequently used local anesthetic drugs in spinal anesthesia practice. Both agents have arrhythmic effects on the heart. However, there is no clear information about which agent is more arrhythmogenic.</AbstractText>The aim of this article is to investigate the effects of bupivacaine ... |
2,336,121 | Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy. | Sphingosine-1-phosphate (S1P) has been shown to possess pro-hypertrophic properties in the heart, but the detailed molecular mechanism that underlies the pathological process is rarely explored. In the present study, we aim to explore the role of S1P-mediated intracellular Ca<sup>2+</sup> signaling, with a focus on sar... |
2,336,122 | Association of OLR1 gene polymorphisms with the risk of coronary artery disease: A systematic review and meta-analysis. | Oxidized LDL receptor 1 (OLR1) encodes LOX-1, LOXIN, and OLR1D4 transcript variants. Up-regulation of LOX-1 and down-regulation of LOXIN have an essential role in causing coronary artery disease (CAD). Discovery of risk single nucleotide polymorphisms (SNPs) in OLR1 gene is clinically important as these polymorphisms c... |
2,336,123 | Autonomic mechanisms of blood pressure alterations during sleep in orexin/hypocretin-deficient narcoleptic mice. | Increase in arterial pressure (AP) during sleep and smaller differences in AP between sleep and wakefulness have been reported in orexin (hypocretin)-deficient mouse models of narcolepsy type 1 (NT1) and confirmed in NT1 patients. We tested whether these alterations are mediated by parasympathetic or sympathetic contro... |
2,336,124 | Spatial phase discontinuity at the center of moving cardiac spiral waves. | Precise analysis of cardiac spiral wave (SW) dynamics is essential for effective arrhythmia treatment. Although the phase singularity (PS) point in the spatial phase map has been used to determine the cardiac SW center for decades, quantitative detection algorithms that assume PS as a point fail to trace complex and ra... |
2,336,125 | Improving care coordination for patients with cardiac disease: Study protocol of the randomised controlled new healthcare programme (Cardiolotse). | A lack of effective coordination and communication between ambulatory care physicians and hospitals, including the lack of follow-up care, poses a challenge to the recovery process of patients suffering from cardiac disease, often resulting in rehospitalisation and adverse outcomes. This innovative care programme aims ... |
2,336,126 | Cardiovascular protective properties of oxytocin against COVID-19. | SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approac... |
2,336,127 | Serratus Anterior Plane Block and Erector Spinae Plane Block Versus Thoracic Epidural Analgesia for Perioperative Thoracotomy Pain Control: A Randomized Controlled Study. | This study was designed to evaluate the safety and efficacy of erector spinae plane block and serratus anterior plane block versus thoracic epidural in perioperative pain control for patients with cancer undergoing lung surgeries.</AbstractText>Single blinded, randomized, controlled trial.</AbstractText>The study was c... |
2,336,128 | Iron Deficiency Anemia in Nigerians with Heart Failure (IDAN-HF): Therapeutic efficacy of iron replacement: An interventional study. | Recent evidence has reported significant improvement in clinical profile, quality of life, and prognosis of heart failure subjects with iron replacement.</AbstractText>This study aimed to determine the safety and outcome of parenteral iron replacement among heart failure subjects in Nigeria.</AbstractText>A randomized ... |
2,336,129 | Awake fiberoptic orotracheal intubation: a protocol feasibility study. | To assess the feasibility of an awake fiberoptic intubation (AFOI) protocol.</AbstractText>We enrolled 40 patients with simulated difficult intubation. The protocol consisted of conscious sedation (midazolam, 0.03 mg/kg and sufentanil, 0.1 µg/kg), regional anesthesia, and intubation. The time, first-attempt... |
2,336,130 | Role of platelets in regulating activated coagulation factor XI activity. | Factor XI (FXI) has been shown to bind platelets, but the functional significance of this observation remains unknown. Platelets are essential for hemostasis and play a critical role in thrombosis, whereas FXI is not essential for hemostasis but promotes thrombosis. An apparent functional contradiction, platelets are k... |
2,336,131 | Reversible complete heart block due to hypercalcaemia. | A 65-year-old woman presented to the emergency room with a syncope. An ECG done revealed complete heart block with a narrow QRS escape rhythm and a normal QT interval. Further investigation revealed severe hypercalcaemia and elevated parathormone levels. Her heart block disappeared on correction of the hypercalcaemia. ... |
2,336,132 | Health-related quality of life among Chinese primary care patients with different lower urinary tract symptoms: a latent class analysis. | No previous study has used a data-driven approach to explore symptom subclasses among patients with lower urinary tract symptoms (LUTS). The objectives of this study were to use latent class analysis (LCA) to identify distinct classes of LUTS among primary care patients and to assess the class differences in health-rel... |
2,336,133 | Bioprinting 3D human cardiac tissue chips using the pin type printer 'microscopic painting device' and analysis for cardiotoxicity. | In this study, three-dimensional (3D) cardiac tissue constructed using the pin type bioprinter 'microscopic painting device' and layer-by-layer cell coating technique was confirmed to have drug responsiveness by three different analytical methods for cardiotoxicity assay. Recently, increasing attention has been focused... |
2,336,134 | Globally defining the effects of mutations in a picornavirus capsid. | The capsids of non-enveloped viruses are highly multimeric and multifunctional protein assemblies that play key roles in viral biology and pathogenesis. Despite their importance, a comprehensive understanding of how mutations affect viral fitness across different structural and functional attributes of the capsid is la... |
2,336,135 | ECPR-extracorporeal cardiopulmonary resuscitation. | Extracorporeal cardiopulmonary resuscitation (ECPR) is a salvage procedure in which extracorporeal membrane oxygenation (ECMO) is initiated emergently on patients who have had cardiac arrest (CA) and on whom the conventional cardiopulmonary resuscitation (CCPR) has failed. Awareness and usage of ECPR are increasing all... |
2,336,136 | Dexamethasone blunts postspinal hypotension in geriatric patients undergoing orthopedic surgery: a double blind, placebo-controlled study. | Post-spinal anesthesia (PSA) hypotension in elderly patients is challenging. Correction of PSA hypotension by fluids either colloids or crystalloids or by vasoconstrictors pose the risk of volume overload or compromising cardiac conditions. Dexamethasone is used to treat conditions manifested by decrease of peripheral ... |
2,336,137 | A study on the bio-applicability of aqueous-dispersed van der Waals 1-D material Nb<sub>2</sub>Se<sub>9</sub> using poloxamer. | In this research, dispersion of a new type of one-dimensional inorganic material Nb<sub>2</sub>Se<sub>9</sub>, composed of van der Waals bonds, in aqueous solution for bio-application study were studied. To disperse Nb<sub>2</sub>Se<sub>9</sub>, which exhibits hydrophobic properties in water, experiments were carried o... |
2,336,138 | Metagenomics survey unravels diversity of biogas microbiomes with potential to enhance productivity in Kenya. | The obstacle to optimal utilization of biogas technology is poor understanding of biogas microbiomes diversities over a wide geographical coverage. We performed random shotgun sequencing on twelve environmental samples. Randomized complete block design was utilized to assign the twelve treatments to four blocks, within... |
2,336,139 | Clinical Efficacy of Pulsed Radiofrequency Treatment Targeting the Mid-cervical Medial Branches for Intractable Cervicogenic Headache. | Cervicogenic headache has been known to originate from the convergence of the upper 3 cervical and trigeminal afferents. The administration of conservative treatments, interventional procedures, and more recently, pulsed radiofrequency, has been used to relieve cervicogenic headache. In this study, the authors evaluate... |
2,336,140 | Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods. | Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active site and either exosite I or exosite II. Herein, we describe the ratio... |
2,336,141 | Reactivity of 3-nitroindoles with electron-rich species. | The indol(in)e building block is one of the "privileged-structures" for the pharmaceutical industry since this fragment plays a central role in drug discovery. While the electron-rich character of the indole motif has been investigated for decades, exploiting the electrophilic reactivity of 3-nitroindole derivatives ha... |
2,336,142 | Rhinovirus-induced CCL17 and CCL22 in Asthma Exacerbations and Differential Regulation by STAT6. | The interplay of type-2 inflammation and antiviral immunity underpins asthma exacerbation pathogenesis. Virus infection induces type-2 inflammation-promoting chemokines CCL17 and CCL22 in asthma; however, mechanisms regulating induction are poorly understood. By using a human rhinovirus (RV) challenge model in human ai... |
2,336,143 | Investigating the Influences of Task Demand and Reward on Cardiac Pre-Ejection Period Reactivity During a Speech-in-Noise Task. | Effort investment during listening varies as a function of task demand and motivation. Several studies have manipulated both these factors to elicit and measure changes in effort associated with listening. The cardiac pre-ejection period (PEP) is a relatively novel measure in the field of cognitive hearing science. Thi... |
2,336,144 | The inter-rater reliability and individual reviewer performance of the 2012 world heart federation guidelines for the echocardiographic diagnosis of latent rheumatic heart disease.<Pagination><StartPage>146</StartPage><EndPage>151</EndPage><MedlinePgn>146-151</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN=... | In 2012, the World Heart Federation (WHF) published guidelines for the echocardiographic diagnosis of rheumatic heart disease (RHD). This study assesses individual reviewer performance and inter-rater agreement and reliability on the presence of any RHD, as well classification of RHD based on the 2012 WHF criteria.</Ab... |
2,336,145 | Rationale and Design of the Genotype-Blinded Trial of Torasemide for the Treatment of Hypertension (BHF UMOD). | Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the uromodulin gene (UMOD) affecting uromodulin excretion and blood pressure (BP). Uromodulin is almost exclusively expressed in the thick ascending limb (TAL) of the loop of Henle and its effect on BP appears to be mediated via... |
2,336,146 | Influence of Levobupivacaine Regional Scalp Block on Hemodynamic Stability, Intra- and Postoperative Opioid Consumption in Supratentorial Craniotomies: A Randomized Controlled Trial. | The anesthetic management of supratentorial craniotomy (CR) necessitates tight intraoperative hemodynamic control. This type of surgery may also be associated with substantial postoperative pain. We aimed at evaluating the influence of regional scalp block (SB) on hemodynamic stability during the noxious events of supr... |
2,336,147 | Cognitive Function After Lung Transplantation. | Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study investigated cognitive impairment after lung transplantation. Patients undergoing bilateral transplant between March 2013 and October 2015 underwent comprehensive neuropsychol... |
2,336,148 | Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profiles. | Neonatal dried blood spots (NDBS) are a widely banked sample source that enables retrospective investigation into early life molecular events. Here, we performed low-pass whole genome bisulfite sequencing (WGBS) of 86 NDBS DNA to examine early life Down syndrome (DS) DNA methylation profiles. DS represents an example o... |
2,336,149 | Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD. | Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells. Several mediators can modulate activation and recruitment of these ... |
2,336,150 | The Effectiveness of Combat Tactical Breathing as Compared with Prolonged Exhalation. | Tactical breathing (TB) is used by military and law enforcement personnel to reduce stress and maintain psychomotor and cognitive performance in dangerous situations (Grossman and Christensen, in On combat: the psychology and physiology of deadly conflict in war and in peace, PPCT Research Publications, Belleville, 200... |
2,336,151 | Low-dose Btk inhibitors selectively block platelet activation by CLEC-2. | Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2 in human platelets. Activation is also blocked in patients with ... |
2,336,152 | Endothelial Vasodilation After a High-Volume Training Load and Tapered Training in Collegiate Female Swimmers. | Weihl, FM and Van Guilder, GP. Endothelial vasodilation after a high-volume training load and tapered training in collegiate female swimmers. J Strength Cond Res 35(3): 811-818, 2021-High-volume endurance training loads have been linked to adverse remodeling of the heart and large arteries; yet, data on the vascular en... |
2,336,153 | Characterization of rainbow trout cell lines using microsatellite DNA profiling. | Ten microsatellite loci (Omy27DU,Omy325(A3)UoG, OmyFGT5TUF,OmyFGT14TUF, OmyFGT15TUF,OmyFGT23TUF, Omy77DU,Ssa20.19NUIG, Ots1BML, andOne18ASC) were amplified using the polymerase chain reaction to create genetic profiles for nine cell lines (RTG-2, RTH-149,RTL-W1,RTgill-W1, RTS-11, RTS-34st, RTP-2, RTP-91E and RTP-91F) f... |
2,336,154 | Fusiform rust of southern pines: a major success for forest disease management. | ABSTRACT The effective management of fusiform rust in slash and loblolly pine plantations is a major success story for disease management scientists and practitioners in the southeastern United States. This disease, which reached epidemic proportions by the 1960s, resulted from anthropogenic causes associated with inte... |
2,336,155 | Spatial and Genetic Analysis of a Flag Shoot Subpopulation of Erysiphe necator in Italy. | ABSTRACT Erysiphe necator overwinters as ascospores in cleistothecia and mycelium in dormant buds of grapevines. Shoots developing from infected buds early in the growing season are covered with dense mycelium and are known as "flag shoots". Combining epidemiological and genetic analyses, the objective of this study wa... |
2,336,156 | Molecular mapping of the leaf rust resistance gene rph6 in barley and its linkage relationships with rph5 and rph7.<Pagination><StartPage>604</StartPage><EndPage>609</EndPage><MedlinePgn>604-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/PHYTO.2003.93.5.604</ELocationID><Abstract><AbstractTex... | ABSTRACT The barley cv. Bolivia carries two leaf rust (Puccinia hordei) resistance genes, Rph2 and Rph6, and is the only known source of the latter gene. A resistant line (Bolivia-Rph6) carrying Rph6 only was obtained in the F(4) generation of a cross between cv. Bolivia and the susceptible cv. Bowman via progeny testi... |
2,336,157 | Genomics and ethics: the case of cloned and/or transgenic animals. | The point of the present study is to illustrate and, if possible, promote the existing link between genomics and ethics, taking the example of cloned and transgenic animals. These 'new animals' raise theoretical and practical problems that concern applied ethics. We will explore more particularly an original strategy s... |
2,336,158 | Dietary supplements and sports performance: introduction and vitamins. | Sports success is dependent primarily on genetic endowment in athletes with morphologic, psychologic, physiologic and metabolic traits specific to performance characteristics vital to their sport. Such genetically-endowed athletes must also receive optimal training to increase physical power, enhance mental strength, a... |
2,336,159 | Pedigree Analysis of the Sika Deer (Cervus nippon) using Microsatellite Markers. | The usefulness of microsatellite markers in pedigree analysis of the sika deer (Cervus nippon) was tested in a herd in which the maternal lineages were recorded. Eighteen sets of microsatellite primers originally designed for bovine, ovine, and cervine loci successfully amplified polymorphic DNA in the deer. The number... |
2,336,160 | The TRAMP mouse as a model for prostate cancer. | The transgenic adenocarcinoma of the mouse prostate (TRAMP) model closely mirrors the pathogenesis of human prostate cancer. Male TRAMP mice uniformly and spontaneously develop autochthonous (orthotopic) prostate tumors following the onset of puberty. Prostate cancer occurs consequent to the expression of SV40 T antige... |
2,336,161 | Adjuvant arthritis in the rat. | Adjuvant arthritis (AA) is an induced form of (sub)chronic arthritis. Strains of rats have a varying genetic susceptibility to AA, whereas mice generally are not susceptible. AA is most easily induced with mycobacteria suspended in oil, although in some strains of rats it can be induced with oily adjuvants in the absen... |
2,336,162 | Fear-potentiated startle in mice. | Pavlovian fear conditioning is frequently used to assess the behavioral, physiological, genetic and molecular correlates of learning and memory. In the typical Pavlovian conditioned fear procedure a neutral stimulus, such as a tone, is paired with a mildly aversive stimulus such as a foot shock. The tone conditioned st... |
2,336,163 | Clinical validity and clinical utility of genetic tests. | In considering the appropriate use of new genetic tests, clinicians and health care policymakers must consider the accuracy with which a test identifies a patient's clinical status (clinical validity) and the risks and benefits resulting from test use (clinical utility). Genetic tests in current use vary in accuracy an... |
2,336,164 | Genetic algorithm-based neural fuzzy decision tree for mixed scheduling in ATM networks. | Future broadband integrated services networks based on asynchronous transfer mode (ATM) technology are expected to support multiple types of multimedia information with diverse statistical characteristics and quality of service (QoS) requirements. To meet these requirements, efficient scheduling methods are important f... |
2,336,165 | The laboratory diagnosis of Haemophilus ducreyi. | Chancroid is a sexually transmitted infection caused by Haemophilus ducreyi. This fastidious, Gram-negative coccobacilli dies rapidly outside the human host, making diagnostic testing using culture methods difficult. This genital ulcer infection is not common in Canada and, therefore, can often be misdiagnosed. The obj... |
2,336,166 | Diagnosis and analysis of a recent case of human rabies in Canada. | On September 30, 2000, staff at the Canadian Food Inspection Agency's Centre of Expertise for Rabies, located at the Animal Diseases Research Institute in Ottawa, Ontario, diagnosed rabies in a child from Quebec. This was the first case of rabies in a human in Canada in 15 years and in 36 years in the province of Quebe... |
2,336,167 | Diagnosis of primary hyperoxaluria type 1 by determination of peritoneal dialysate glycolic acid using standard organic-acids analysis method. | Hyperglycolic hyperoxaluria is an important biochemical diagnostic hallmark for primary hyperoxaluria type 1 (PH1). Biochemical work-up on urinary specimens becomes impossible after the development end-stage renal failure and anuria. We studied the diagnostic value of determining glycolic acid content in peritoneal dia... |
2,336,168 | Clinical use of cord blood for stem cell transplantation. | Allogeneic bone marrow transplantations (BMT) from HLA-matched siblings have been successfully used for treatment of patients with high-risk hematological malignancies, genetic immunodeficiencies, metabolic disorders, or marrow failure syndromes. Unfortunately, most of patients lack matched related donors. Over the pas... |
2,336,169 | Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia. | X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the Bruton tyrosine kinase (Btk) gene. In order to identify the mutations in Btk gene in Iranian patients with antibody deficiency, 13 male patients with an XLA phenotype from 11 unrelated families were enrolled as the subjects of investiga... |
2,336,170 | Wrongful life and wrongful birth: legal aspects of failed genetic testing in oocyte donation. | The field of reproductive medicine has all but exploded in recent years, allowing more people access to novel treatments. New technologies have been introduced so rapidly that ethics and the law have been unable to respond appropriately. A particularly promising reproductive therapy, oocyte donation, and the wide varie... |
2,336,171 | Contact-based Simulated Annealing Protein Sequence Alignment Method. | Protein sequence alignments reveal the evolutionary information between homologous sequences. Traditional sequence alignment methods only use sequence information and the structure information from template is ignored. Recently, Kleinjung et al. developed a contact-based sequence alignment method that used the structur... |
2,336,172 | Integrated microfluidic biochips for immunoassay and DNA bioassays. | Bioassays involve multi-stage sample processing and fluidic handling, which are generally labor-intensive and time-consuming. Using microfluidic technology to integrate and automate all these steps in a single chip device is highly desirable in many practical applications such as clinical diagnostic and in-field enviro... |
2,336,173 | Prediction of aqueous solubility based on large datasets using several QSPR models utilizing topological structure representation. | Several QSPR models were developed for predicting intrinsic aqueous solubility, S(o). A data set of 5,964 neutral compounds was sub-divided into two classes, aromatic and non-aromatic compounds. Three models were created with different methods on both data sets: two regression models (multiple linear regression and par... |
2,336,174 | Presence of potential allergy-related linear epitopes in novel proteins from conventional crops and the implication for the safety assessment of these crops with respect to the current testing of genetically modified crops. | Mitochondria of cytoplasmic male sterile crop plants contain novel, chimeric open reading frames. In addition, a number of crops carry endogenous double-stranded ribonucleic acid (dsRNA). In this study, the novel proteins encoded by these genetic components were screened for the presence of potential binding sites (epi... |
2,336,175 | Internal and external factors affecting the development of neuropathic pain in rodents. Is it all about pain?<Pagination><StartPage>326</StartPage><EndPage>342</EndPage><MedlinePgn>326-42</MedlinePgn></Pagination><Abstract><AbstractText>It is important to know the factors that will influence animal models of neuropathi... | It is important to know the factors that will influence animal models of neuropathic pain. A good reproducibility and predictability in different strains of animals for a given test increases the clinical relevance and possible targeting. An obligatory requirement for enabling comparisons of results of different origin... |
2,336,176 | Discovering gene networks with a neural-genetic hybrid. | Recent advances in biology (namely, DNA arrays) allow an unprecedented view of the biochemical mechanisms contained within a cell. However, this technology raises new challenges for computer scientists and biologists alike, as the data created by these arrays is often highly complex. One of the challenges is the elucid... |
2,336,177 | Recent developments in celiac disease. | Celiac disease is a common disorder associated with a substantially increased standardized mortality ratio if it is left untreated or if the diagnosis is delayed. Diagnostic sensitivity of serologic testing is improved by the addition of IgG-based testing to standard IgA-based serologic testing for endomysial or transg... |
2,336,178 | Pediatric inflammatory bowel disease: clinical and therapeutic aspects. | Epidemiologic data suggest that the incidences of pediatric ulcerative colitis and Crohn disease continue to evolve with geographic variations. One study suggests that children with autism have a unique inflammatory bowel disorder that is associated with gastrointestinal symptoms. The appropriate use of new diagnostic ... |
2,336,179 | [Interest in breast cancer genetic testing among Icelandic women.]. | It is estimated that 6-10% of all breast cancers in Iceland can be attributed to inherited mutations in newly identified breast cancer susceptibility genes (BRCA1 and BRCA2). Before genetic testing becomes widely available in Iceland it is important to understand what motivates women s interest in undergoing testing as... |
2,336,180 | Perioperative management of a common disorder: hereditary haemochromatosis. | Hereditary haemochromatosis is the commonest autosomal recessive disorder affecting Caucasian populations, and is readily diagnosed on the basis of elevated total body iron stores and genetic testing. Increased awareness of this disease in the community will hopefully prompt earlier testing and diagnosis. Treatment wit... |
2,336,181 | Genotoxicity screening: the slow march to the future. | Genetic toxicology testing in drug discovery and development is slowly moving into the age of high-throughput screening (HTS). This has been helped by the development of new tools, as well as validation studies and data analysis to support their use in hit-to-lead or lead optimisation decisions. This review provides an... |
2,336,182 | [How to improve the screening and diagnosis of fetal aneuploidy?]. | In France, prenatal screening for fetal aneuploidies is legally regulated and is based on second-trimester maternal serum screening at 15-18 weeks. In 2000, 15% of all pregnant women in the Yvelines district of Greater Paris underwent amniocentesis, for a background risk of 11300. This high rate of invasive testing is ... |
2,336,183 | Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization. | Materials play a key role in several biomedical applications, and it is imperative that both the materials and biological aspects are clearly understood for attaining a successful biological outcome. This paper illustrates our approach to implement calcium phosphates as gene delivery agents. Calcium phosphates (CaP) be... |
2,336,184 | Vicious circles: positive feedback in major evolutionary and ecological transitions. | Evolutionary biologists and ecologists often focus on equilibrium states that are subject to forms of negative feedback, such as optima for phenotypic traits or regulation of population sizes. However, recent theoretical and empirical studies show how positive feedback can be instrumental in driving many of the most im... |
2,336,185 | Genic capture and resolving the lek paradox. | The genic capture hypothesis offers a resolution to the question of how genetic variation in male sexually selected traits is maintained in the face of strong female preferences. The hypothesis is that male display traits are costly to produce and hence depend upon overall condition, which itself is dependent upon gene... |
2,336,186 | Structured antedependence models for functional mapping of multiple longitudinal traits. | In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by mathematical aspects of growth processes to model the mean ve... |
2,336,187 | Telling the difference between frontotemporal dementia and Alzheimer's disease.<Pagination><StartPage>628</StartPage><EndPage>632</EndPage><MedlinePgn>628-32</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE OF REVIEW" NlmCategory="OBJECTIVE">A precise diagnosis of the cause of dementia during life is nee... | In this research, Professor Jürgen Simon and Christian Ravenstein have highlighted the general existing prohibition, in the labour field, of the undertaking of genetic tests that could mean discrimination for the genetic heritage of the worker. They have made a comparative study of several member States of the EU ... |
2,336,188 | Plasmid vaccines and therapeutics: from design to applications.<Pagination><StartPage>41</StartPage><EndPage>92</EndPage><MedlinePgn>41-92</MedlinePgn></Pagination><Abstract><AbstractText>In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various prote... | In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in the uptake of the plasmid by cells and expression of the encoded proteins. After this discovery, a period of technological improvements in plasmid delivery and expression a... |
2,336,189 | The evolving role of proteomics in the early detection of breast cancer. | There has been emerging interest in the examination of tumor protein expression (proteomics) as a means to identify novel diagnostic and therapeutic targets in women with breast cancer. Specifically, several investigators have examined biological fluids (serum and breast ductal fluid) and breast tissue in an attempt to... |
2,336,190 | Identifying genetic variation affecting a complex trait in simulated data: a comparison of meta-analysis with pooled data analysis. | We explored the power and consistency to detect linkage and association with meta-analysis and pooled data analysis using Genetic Analysis Workshop 14 simulated data. The first 10 replicates from Aipotu population were used. Significant linkage and association was found at all 4 regions containing the major loci for Ko... |
2,336,191 | Analysis of binary traits: testing association in the presence of linkage. | Most methods for testing association in the presence of linkage, using family-based studies, have been developed for continuous traits. FBAT (family-based association tests) is one of few methods appropriate for discrete outcomes. In this article we describe a new test of association in the presence of linkage for bina... |
2,336,192 | Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. | Simulated Genetic Analysis Workshop 14 data were analyzed by jointly testing linkage and association and by accounting for epistasis using a candidate gene approach. Our group was unblinded to the "answers." The 48 single-nucleotide polymorphisms (SNPs) within the six disease loci were analyzed in addition to five SNPs... |
2,336,193 | Olfactory function in people with genetic risk of dementia.<Pagination><StartPage>46</StartPage><EndPage>50</EndPage><MedlinePgn>46-50</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Screening for sensorial impairment is a secondary objective in the context of neurodegenerat... | The majority of the investigation methods of biochemical, morphological and metabolic disorders in hepatic insufficiency and encephalopathy occurrence are inadequate in use in clinical conditions because their invasiveness frequently creates dangerous situations to the patient life and health. That's why, to characteri... |
2,336,194 | Support versus corroboration. | Numerous metrics have been developed that attempt to assess the reliability of phylogenetic trees. Several of these commonly used measures of tree and tree branch support are described and discussed in the context of their relationship to Popperian corroboration. Claims that measures of support indicate the accuracy of... |
2,336,195 | [Hereditary non polyposis colon cancer--basic principle and ethical considerations]. | HNPCC is a hereditary cancer syndrome of several organs but more particularly the colon and the uterus. It is characterized by microsatellite instability (MSI) related to mutations of DNA mismatch repair (MMR) genes. The role of the pathologist in the detection of colorectal cancer with MSI phenotype is important. Amon... |
2,336,196 | The evolution of genetic architecture. I. Diversification of genetic backgrounds by genetic drift. | The genetic architecture of a phenotype plays a critical role in determining phenotypic evolution through its effects on patterns of genetic variation. Genetic architecture is often considered to be constant in evolutionary quantitative genetic models. However, genetic architecture may be variable and itself evolve whe... |
2,336,197 | Identification of amyloid-beta 1-42 binding protein fragments by screening of a human brain cDNA library. | Extracellular and intraneuronal formation of amyloid-beta (Abeta) deposits have been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). However, the precise mechanism of Abeta neurotoxicity is not completely understood. Previous studies suggest that binding of Abeta with a number of targets ha... |
2,336,198 | Hereditary ataxia and behavior. | Recognizing cognitive deficits and psychiatric disorders in patients with autosomal dominant ataxias is relatively new. At this time, the percentage of patients with these disorders who experience changes in cognition or psychiatric symptoms is unknown. Cognitive impairment, when seen, is often found on tests of execut... |
2,336,199 | Hydrogel-beta-TCP scaffolds and stem cells for tissue engineering bone. | Trabecular bone is a material of choice for reconstruction after trauma and tumor resection and for correction of congenital defects. Autologous bone grafts are available in limited shapes and sizes; significant donor site morbidity is another major disadvantage to this approach. To overcome these limitations, we used ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.