Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,325,300 | Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. | Papillary tumor of the pineal region (PTPR) is an uncommon neoplasm with variable biologic behavior. Cytogenetic and molecular diagnostic studies are rare, yielding no definitive genetic signature. We report a case of PTPR with a multicentric presentation and unusual cytogenetic features. A 25-year-old man presented wi... |
2,325,301 | Does release of antimicrobial agents from impregnated external ventricular drainage catheters affect the diagnosis of ventriculitis?<Pagination><StartPage>375</StartPage><EndPage>381</EndPage><MedlinePgn>375-81</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3171/2014.12.JNS141900</ELocationID><Abstr... | Multiciliated ependymal cells line the ventricles in the adult brain. Abnormal function or structure of ependymal cilia is associated with various neurological deficits. The current ex vivo live imaging of motile ependymal cilia technique allows for a detailed study of ciliary dynamics following several steps. These st... |
2,325,302 | Kyphectomy and Pedicular Screw Fixation with Posterior-Only Approach in Pediatric Patients with Myelomeningocele. | Defective posterior spinal arch and paraspinal musculature lead to progressive kyphosis in patients with myelomeningocele. Kyphosis decreases the patients' functional status and quality of life. To correct or prevent further deterioration, different surgical techniques have been introduced. Our aim is to present our cl... |
2,325,303 | Transcatheter Removal of Embolized Port Catheters from the Hearts of Two Children. | Embolization of a port catheter is a dangerous and serious complication. In this paper, we present two cases of children, aged 4.5 months and 6 years, in whom port catheters had embolized to the right ventricle one month and 1.5 years priorly, respectively; the port catheters were retrieved via snaring. |
2,325,304 | Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons. | Both lateral hypothalamic orexinergic neurons and hindbrain catecholaminergic neurons contribute to control of feeding behavior. Orexin fibers and terminals are present in close proximity to hindbrain catecholaminergic neurons, and fourth ventricular (4V) orexin injections that increase food intake also increase c-Fos ... |
2,325,305 | Cognitive Impairment and Brain Imaging Characteristics of Patients with Congenital Cataracts, Facial Dysmorphism, Neuropathy Syndrome. | Congenital cataracts, facial dysmorphism, neuropathy (CCFDN) syndrome is a complex autosomal recessive multisystem disorder. The aim of the current study is to evaluate the degree of cognitive impairment in a cohort of 22 CCFDN patients and its correlation with patients' age, motor disability, ataxia, and neuroimaging ... |
2,325,306 | Neuromyelitis optica with linear enhancement of corpus callosum in brain magnetic resonance imaging with contrast: a case report. | Neuromyelitis optica is a demyelinating disease of the central nervous system with various patterns of brain lesions. Corpus callosum may be involved in both multiple sclerosis and neuromyelitis optica. Previous case reports have demonstrated that callosal lesions in neuromyelitis optica are usually large and edematous... |
2,325,307 | Recurrent subependymoma of fourth ventricle with unusual atypical histological features: A case report. | Subependymoma is a rare subtype of benign ependymal neoplasm with distinct histological features. Anaplastic transformation has not yet been reported in this tumor to date. We present here a very unusual case of a 62-year-old woman with recurrent subependymoma of the fourth ventricle with multiple atypical histological... |
2,325,308 | Resection of right ventricular metastasis subsequent to liver transplant for hepatocellular carcinoma. | We report a case of a 54-year-old Caucasian male with exertional dyspnea who underwent palliative resection of a solitary right ventricular metastasis one year after liver transplant for a multifocal HBV-related hepatocellular carcinoma (HCC). After nine months the patient remains asymptomatic and cardiac MRI shows no ... |
2,325,309 | Use of preoperative FLAIR MRI and ependymal proximity of tumor enhancement as surrogate markers of brain tumor origin. | Neural stem cells proliferate in the subventricular zone and give rise to progeny that differentiate and migrate throughout the brain. We aimed to test the hypothesis that glioma behavior and grade may correlate with the identity of the tumor cell of origin. We evaluated three preoperative radiographic features (fluid ... |
2,325,310 | Methotrexate myelopathy after intrathecal chemotherapy: a case report. | Methotrexate is often administered intrathecally or into the cerebral ventricles, particularly in patients with central nervous system tumors. However, in addition to chemical arachnoiditis, methotrexate can induce severe myelopathy.</AbstractText>A 59-year-old Japanese man with diffuse B-cell lymphoma who underwent sy... |
2,325,311 | Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials. | Current platforms for in vitro drug development utilize confluent, unorganized monolayers of heart cells to study the effect on action potential propagation. However, standard cell cultures are of limited use in cardiac research, as they do not preserve important structural and functional properties of the myocardium. ... |
2,325,312 | Resolution of precocious puberty following resection of fourth ventricular medulloblastoma: case report. | Medulloblastoma is a malignant embryonal tumor that arises in the cerebellum and invades the fourth ventricle, often resulting in obstructive hydrocephalus. Patients typically present with symptoms related to increased intracranial pressure and cerebellar dysfunction. The authors report a rare case of classic medullobl... |
2,325,313 | Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control. | Primary cilia are sensory organelles that harbor various receptors such as G protein-coupled receptors (GPCRs). We analyzed subcellular localization of 138 non-odorant GPCRs. We transfected GPCR expression vectors into NIH3T3 cells, induced ciliogenesis by serum starvation, and observed subcellular localization of GPCR... |
2,325,314 | Cognitive function and brain structure after recurrent mild traumatic brain injuries in young-to-middle-aged adults. | Recurrent mild traumatic brain injuries (mTBIs) are regarded as an independent risk factor for developing dementia in later life. We here aimed to evaluate associations between recurrent mTBIs, cognition, and gray matter volume and microstructure as revealed by structural magnetic resonance imaging (MRI) in the chronic... |
2,325,315 | Effects of folinic acid and fluorouracil chemotherapy on right ventricle func-tions as assessed with tricuspid annular plane systolic excursion. | This study aimed to investigate the effects of folinic acid and fluorouracil (bolus FUFA regimen) chemotherapy on right ventricle (RV) functions.</AbstractText>Thirty-four gastrointestinal (GI) cancer patients treated with antineoplastic drugs were included the study. All participants received FUFA chemotherapy protoco... |
2,325,316 | Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress. | It is believed that glucocorticoids control the proliferation of neural progenitor cells, and this process is highly involved in mood disorders and cognitive processes. Using the maternal separation model of chronic neonatal stress, it has been found that stress induced depressive-like behavior, cognitive deficits and ... |
2,325,317 | Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells. | Transforming growth factor beta 1 (TGF-beta1), an anti-inflammatory cytokine, has been shown to have pro-neurogenic effects on adult Neural Stem Cells (aNSC) from the dentate gyrus and in vivo models. Here, we expanded the observation of the pro-neurogenic effect of TGF-beta1 on aNSC from the subventricular zone (SVZ) ... |
2,325,318 | Energetic costs of protein synthesis do not differ between red- and white-blooded Antarctic notothenioid fishes. | Antarctic icefishes (Family Channichthyidae) within the suborder Notothenioidei lack the oxygen-binding protein hemoglobin (Hb), and six of the 16 species of icefishes lack myoglobin (Mb) in heart ventricle. As iron-centered proteins, Hb and Mb can promote the formation of reactive oxygen species (ROS) that damage biol... |
2,325,319 | Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease. | Huntington's disease (HD) is caused by an expansion of glutamine repeats in the huntingtin protein (mHtt) that invokes early and prominent damage of the striatum, a region that controls motor behaviors. Despite its ubiquitous expression, why certain brain regions, such as the cerebellum, are relatively spared from neur... |
2,325,320 | Posterior fossa ependymoma in childhood: 60 years event-free survival after partial resection—a case report. | A 13-year-old boy with severe clinical symptoms and signs underwent surgery for a posterior fossa ependymoma in 1954. The tumor was adjacent to the floor of the fourth ventricle, and surgery was complicated by profound bleeding. Therefore, only a partial resection was performed. Postoperative radiotherapy was given to ... |
2,325,321 | Physical exercise affects slow cycling cells in the rat heart and reveals a new potential niche area in the atrioventricular junction. | Physical exercise has several beneficial effects on the heart. In other tissues it has been shown to activate endogenous stem cells. There is however a lack of knowledge how exercise affects the distribution of progenitor cells as well as overall cell turnover within the heart. Therefore, proliferating cells were ident... |
2,325,322 | Photoperiod affects the cerebrospinal fluid proteome: a comparison between short day- and long day-treated ewes. | Photoperiod is the main physical synchronizer of seasonal functions and a key factor in the modulation of molecule access to cerebrospinal fluid (CSF) in animals. Previous work has shown that photoperiod affects the transfer rate of steroids and protein hormones from blood to CSF and modulates choroid plexus tight junc... |
2,325,323 | Relationship between ventricular size, white matter injury, and neurocognition in children with stable, treated hydrocephalus. | Larger-than-normal ventricles can persist in children following hydrocephalus treatment, even if they are asymptomatic and clinically well. This study aims to answer the following question: do large ventricles result in brain injuries that are detectable on diffusion tensor imaging (DTI) and/or in measurable neurocogni... |
2,325,324 | Pro- and Anticonvulsant Effects of the Ant Dinoponera quadriceps (Kempf) Venom in Mice. | Epilepsy affects at least 50 million people worldwide, and the available treatment is associated with various side effects. Approximately 20-30% of the patients develop seizures that persist despite careful monitored treatment with antiepileptic drugs. Thus, there is a clear need for the development of new antiepilepti... |
2,325,325 | Neuroimaging and clinical characterization of Sotos syndrome. | Sotos syndrome is a well-known overgrowth syndrome characterized by excessive growth during childhood, macrocephaly, distinctive facial appearance and learning disability. This disorder is caused by mutations or deletions in NSD1 gene. The aim of this study is to examine the relationship between the neuroimaging and cl... |
2,325,326 | Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism. | Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function and synaptic connectivity of input from DMH cholinergic neurons to sympathetic premotor ne... |
2,325,327 | Estrogen Selectively Mobilizes Neural Stem Cells in the Third Ventricle Stem Cell Niche of Postnatal Day 21 Rats. | The neuroprotective properties of stem cells have been described for various pathophysiological states. Here, we determined the effects of exogenous perinatal estrogen treatment on endogenous neural stem cell activity in the third ventricle stem cell niche (3VSCN) and the caudal third ventricle (C3V). Pregnant Sprague-... |
2,325,328 | Glioneuronal tumours with features of rosette-forming glioneuronal tumours of the fourth ventricle and dysembryoplastic neuroepithelial tumours: a report of three cases. | To study three atypical glioneuronal tumours (GNTs), in order to shed light on the clinical and pathological features of this diverse tumour group.</AbstractText>Clinical and neuropathological data for each case were retrospectively reviewed. Case 1 involved a 17-year-old boy with left leg movement difficulty. A mass l... |
2,325,329 | Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. | Recent studies clearly demonstrate major histocompatibility complex (MHC) class I expression in the brain plays an important functional role in neural development and plasticity. A previous study from our laboratory demonstrated the temporal and spatial expression patterns of classical MHC class I molecules in the brai... |
2,325,330 | Morphological manifestations of the Dandy-Walker syndrom in female members of a family. | The Dandy-Walker syndrome (DWS) is a hereditary disorder, appearing somewhat more frequently in women. The most important characteristics of the DWS are the lack of the cerebellar vermis, varying from a partial lack to a complete agenesis, and enlargement of the cerebrospinal spaces, especially in the fourth ventricle.... |
2,325,331 | Multifocal lateral and fourth ventricular primary central nervous system lymphoma: case report and literature review. | We report a 66-year-old man with 2-month history of dizziness and 1-month history of diplopia. Cranial magnetic resonance imaging (MRI) disclosed two solid masses, one in the right lateral ventricle and another in the fourth ventricle. A surgical biopsy was performed on the basis of safety. The diagnosis of large B-cel... |
2,325,332 | Endoscopic transaqueductal removal of fourth ventricular neurocysticercosis: report of three cases. | In this study, we try to present our experience of transaqueductal removal of the fourth ventricular neurocysticercosis (FVNCC) with a flexible neuroendoscope. Three cases of the fourth ventricular cysticercosis were transaqueductally removed with FUJINON EB-270P flexible neuroendoscope through a frontal precoronal bur... |
2,325,333 | Management of colloid cyst of third ventricle. | Colloid cysts are usually located in third ventricle and are believed to be derived from either primitive neuroepithelium or endoderm. Patients may remain asymptomatic for long time while some can present with paroxysmal headache, gait disturbance, nausea, vomiting, behavioral changes, weaknesses of lower limbs, impair... |
2,325,334 | Pediatric central nervous system solitary fibrous tumor: case report. | Solitary fibrous tumors are mesenchymally derived masses most commonly originating from the lung pleura.</AbstractText>Herein, we report a 6-month-old presenting with syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a suprasellar mass. The mass proved to be a solitary fibrous tumor. This case and sa... |
2,325,335 | Prevalence of cavum septum pellucidum and/or cavum Vergae in brain computed tomographies of Taiwanese. | The reported prevalence of cavum septum pellucidum (CSP) and cavum Vergae (CV) in brain computed tomography (CT) is 5.5% in Great Britain and 1.24% in China but unknown in Taiwan. Moreover, CSP and/or CV has generally been thought to decrease as age progresses, but the evidence of actual prevalence at different age lev... |
2,325,336 | Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. | The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter neuroimaging data, we analyzed brain MRI scans from 2028 schizophrenia patients and 2540 healthy controls... |
2,325,337 | Neurogenesis in the adult avian song-control system. | New neurons are added throughout the forebrain of adult birds. The song-control system is a model to investigate the addition of new long-projection neurons to a cortical circuit that regulates song, a learned sensorimotor behavior. Neuroblasts destined for the song nucleus HVC arise in the walls of the lateral ventric... |
2,325,338 | The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1. | Production of olfactory bulb neurons occurs continuously in the rodent brain. Little is known, however, about cellular diversity in the glutamatergic neuron subpopulation. In the central nervous system, the basic helix-loop-helix transcription factor NeuroD1 (ND1) is commonly associated with glutamatergic neuron develo... |
2,325,339 | Anterior nuclear deep brain stimulation guided by concordant hippocampal recording. | Anterior nuclear (AN) stimulation has been reported to reduce the frequency of seizures, in some cases dramatically; however, it has not been approved by the US Food and Drug Administration. The anterior nucleus is difficult to target because of its sequestered location, partially surrounded by the ventricle. It has tr... |
2,325,340 | Syringohydromyelia in association with syringobulbia and syringocephaly: case report. | The authors present the case of a 14-year-old boy with holocord syringohydromyelia extending into the brainstem, cerebral peduncle, internal capsule, and cerebral cortex. At the posterior fossa exploration, an opaque thickened arachnoid with occlusion of the foramen of Magendie was encountered. Careful documentation of... |
2,325,341 | Epigenetic regulation of stemness maintenance in the neurogenic niches. | In the adult mouse brain, the subventricular zone lining the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus are two zones that contain neural stem cells (NSCs) with the capacity to give rise to neurons and glia during the entire life of the animal. Spatial and temporal regulation of... |
2,325,342 | A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis. | In humans, in utero exposure to ionising radiation results in an increased prevalence of neurological aberrations, such as small head size, mental retardation and decreased IQ levels. Yet, the association between early damaging events and long-term neuronal anomalies remains largely elusive.</AbstractText>Mice were exp... |
2,325,343 | Skeletal shape correspondence via entropy minimization. | Improving the shape statistics of medical image objects by generating correspondence of interior skeletal points.</AbstractText>Synthetic objects and real world lateral ventricles segmented from MR images.</AbstractText>Each object's interior is modeled by a skeletal representation called the s-rep, which is a quadrila... |
2,325,344 | A severe case of systemic lupus erythematosus with increased pressure communicating hydrocephalus. | Normal/increased pressure hydrocephaly is an unusual manifestation of systemic lupus erythematosus (SLE), and the pathogenesis is still unclear. We report the case of an 18-year-old white female with severe refractory renal and pulmonary involvement who developed stupor during intensive immunosuppressive treatment. Enl... |
2,325,345 | Bilateral Choroid Plexus Metastasis from Papillary Thyroid Carcinoma: Case Report and Review of the Literature. | Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. It has an indolent clinical course and favorable prognosis. Brain metastasis is uncommon and complicates about 0.1%-5% of PTCs. Metastasis to the choroid plexus of the lateral ventricles has been reported in 7 cases of thyroid malignancies, al... |
2,325,346 | The expression of interleukin-6 and its receptor in various brain regions and their roles in exploratory behavior and stress responses. | We examined the involvement of interleukin-6 (IL-6) and its receptor IL-6Rα on behavior and stress responses in mice. In the open field, both wild-type (WT) and IL-6 deficient mice displayed similar levels of locomotor activity; however, IL-6 deficient mice spent more time in the central part of the arena compare... |
2,325,347 | Cardiovascular target organ damage could have been detected in sustained pediatric hypertension. | The aim of this study was to assess sustained hypertension in children and its impact on cardiovascular target organ damage (TOD). Blood pressure (BP) was measured in children in Beijing in 2009. Primary hypertension was diagnosed based on three separate visits. Hypertensive children and normotensive children were foll... |
2,325,348 | Avoidance and management of perioperative complications of endoscopic third ventriculostomy: the Dhaka experience. | Although endoscopic third ventriculostomy (ETV) is a minimally invasive procedure, serious perioperative complications may occur due to the unique surgical maneuvers involved. In this paper the authors report the complications of elective and emergency ETV and their surgical management in 412 patients from July 2006 to... |
2,325,349 | Ventricular and vascular stiffening in aging and hypertension. | The assessment of arterial stiffness, a common feature of aging, exacerbated by pathological conditions like hypertension, has become an attractive tool for identifying structural and functional changes of the arteries even in an early stage of the atherosclerotic disease. Arterial stiffness has been recognized as an i... |
2,325,350 | Endoscopic Third Ventriculostomy in Children with Myelomeningocele: A Case Series. | Hydrocephalus develops in up to 80-90% of children with myelomeningocele (MM) after closure of the defect. Traditionally, ventriculoperitoneal shunts have been used to manage hydrocephalus in these patients. A role for endoscopic third ventriculostomy (ETV) in MM has provoked much debate, principally due to anatomical ... |
2,325,351 | Combined microsurgical extra-axial and transcortical transventricular endoscopic excision of parasellar tumors with ventricular extension. | Sella/parasellar tumors with intraventricular extension present unique neurosurgical challenges in achieving gross total resection with minimal morbidity and mortality. Firm attachment of large tumors, especially craniopharyngiomas, in this location to critical structures, makes the goal of complete microsurgical resec... |
2,325,352 | Galen's (130-201 AD) Conceptions of the Heart. | In the 2nd century AD, the prolific Greek physician Galen contributed significantly to the anatomical and physiological knowledge of the cardiovascular system. However his erroneous theory of blood circulation, based on the inaccurate notion that venous blood passes through tiny pores in the heart's septum, moves from ... |
2,325,353 | Interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats. | The cholinergic system plays an important role in learning and memory. This study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in adult male Wistar rats.</AbstractText>At first, an injection cannula was implant... |
2,325,354 | Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. | We examined the potential benefit of gene therapy in a mouse model of tuberous sclerosis complex (TSC) in which there is embryonic loss of Tsc1 (hamartin) in brain neurons. An adeno-associated virus (AAV) vector (serotype rh8) expressing a tagged form of hamartin was injected into the cerebral ventricles of newborn pup... |
2,325,355 | Chordoid glioma: a rare radiologically, histologically, and clinically mystifying lesion. | Chordoid glioma (CG) is a rare central nervous system neoplasm (WHO grade II) of uncertain origin whose typical localization is in the anterior part of the third ventricle. Its clinical, radiological, and histological features may vary and furthermore mimic other kind of benign lesions usually associated with a better ... |
2,325,356 | In Vivo Expression of the PTB-deleted Odin Mutant Results in Hydrocephalus. | Odin has been implicated in the downstream signaling pathway of receptor tyrosine kinases, such as the epidermal growth factor and Eph receptors. However, the physiologically relevant function of Odin needs to be further determined. In this study, we used Odin heterozygous mice to analyze the Odin expression pattern; t... |
2,325,357 | Imaging features of rosette-forming glioneuronal tumours (RGNTs): A Series of seven cases. | Rosette-forming glioneuronal tumours (RGNTs) are a recently described, rare, distinct nosological entity of the glioneuronal family. We describe imaging findings (CT and MRI) in seven patients with RGNTs.</AbstractText>This retrospective study includes seven RGNT patients (4 male, 3 female; age range: 7-42 years; mean ... |
2,325,358 | Anatomical organization of the rat organum vasculosum laminae terminalis. | The organum vasculosum of the laminae terminalis (OVLT) is a circumventricular organ located along the ventral part of the anterior wall of the third ventricle. Because it lacks a complete blood-brain barrier (BBB), blood-borne signals detected in the OVLT provide the brain with information from the periphery and contr... |
2,325,359 | Papillary glioneuronal tumor: case report and review of literature. | Papillary glioneuronal tumor (PGNT) is a recently described central nervous system neoplasm that mostly occurs in the supratentorial system, adjacent to the lateral ventricles. In 2007, WHO classified PGNT as grade I neuronal-glial tumor because of the characteristic papillary architecture and bipartite (astrocytic and... |
2,325,360 | Superior medullary velum: anatomical-histological study in the sheep brain and a preliminary tractographic study in the human brain. | To study the anatomy, histology and fiber relations of the superior medullary velum.</AbstractText>Ten previously frozen and formalin-fixed sheep brains were used. The fiber dissection was done using the operating microscope at the Rhoton Anatomy Laboratory of Marmara Faculty of Medicine. A tractographic study was cond... |
2,325,361 | Mercury and selenium concentrations in skeletal muscle, liver, and regions of the heart and kidney in bearded seals from Alaska, USA. | Mean concentrations of total mercury ([THg]) and selenium ([TSe]) (mass and molar-based) were determined for 5 regions of the heart and 2 regions of the kidney of bearded seals (Erignathus barbatus) harvested in Alaska, USA, in 2010 and 2011. Mean [THg] and [TSe] of bearded seal liver and skeletal muscle tissues were u... |
2,325,362 | A Novel Monoclonal Antibody Against Neuroepithelial and Ependymal Cells and Characteristics of Its Positive Cells in Neurospheres. | There are still few useful cell membrane surface antigens suitable for identification and isolation of neural stem cells (NSCs). We generated a novel monoclonal antibody (mAb), designated as mAb against immature neural cell antigens (INCA mAb), which reacted with the areas around a lateral ventricle of a fetal cerebrum... |
2,325,363 | The RAGE receptor and its ligands are highly expressed in astrocytes in a grade-dependant manner in the striatum and subependymal layer in Huntington's disease. | Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of the CAG repeat in the huntingtin gene. One of the brain changes that occurs in HD is the expression of the receptor for advanced glycation end products (RAGE), a receptor protein capable of activating multiple signall... |
2,325,364 | Effects of Microglia on Neurogenesis. | This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the or... |
2,325,365 | MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging. | Ependymal cells (ECs) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in ECs decline significantly during aging in mice. The longevity of these functions in part requires t... |
2,325,366 | Long-term methionine-diet induced mild hyperhomocysteinemia associated cardiac metabolic dysfunction in multiparous rats. | Mild hyperhomocysteinemia (HHcy, clinically defined as less than 30 μmol/L) is an independent cardiovascular disease (CVD) risk factor, and is associated with many complications during pregnancy, such as preeclampsia (PE). The aim of this study was to assess the effect of long-term mild HHcy on cardiac metab... |
2,325,367 | Endoscopic Approaches to Intraventricular Lesions. | Endoscopy is becoming increasingly popular for the neurosurgical management of intraventricular lesions and has recently been accepted as an effective alternative approach to open surgery. The deep location of intraventricular lesions makes the microsurgical approach difficult. Moreover, many intraventricular tumors do... |
2,325,368 | Can lateral ventricle contact predict the ontogeny and prognosis of glioblastoma? | Lateral ventricle contact (LVC) by glioblastomas has been proposed to reveal their origin and may have prognostic value; however, results from previous studies have been controversial. This study explored the association between LVC and tumor origin and prognosis in glioblastoma patients. Magnetic resonance imaging and... |
2,325,369 | Prodromal Symptom Severity Predicts Accelerated Gray Matter Reduction and Third Ventricle Expansion Among Clinically High Risk Youth Developing Psychotic Disorders. | A recent prospective longitudinal neuroimaging study of 274 prodromal risk syndrome subjects revealed that those who later developed full-blown psychotic symptoms exhibited accelerated gray matter loss and third ventricle expansion around the time of onset of psychosis. Previous studies also indicate that higher levels... |
2,325,370 | Role of Hypertension and Anaemia in Left Ventricular Remodelling in Patient with Renal Allograft in the First Post-transplant Year. | Hypertension (HT) and renal anaemia (RA) are well-established markers of cardiovascular risk in patients with chronic kidney disease (CKD). They appear to be the stimuli for left ventricular hypertrophy (LVH), who significantly participates in cardiac complications in uremic patients. Hypertension is extremely common a... |
2,325,371 | Presynaptically mediated effects of cholecystokinin-8 on the excitability of area postrema neurons in rat brain slices. | Cholecystokinin (CCK) is a well-known gut hormone that shows anorexigenic effects via action at peripheral and central receptors. CCK is also widely distributed throughout the mammalian brain and appears to function as a neurotransmitter and neuromodulator. The area postrema is one of the circumventricular organs, loca... |
2,325,372 | Morphometric and neurochemical alterations found in l-BMAA treated rats. | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis that reflects the motoneurons' degeneration. Several studies support the relationship between β-N-methylamino-l-alanine (l-BMAA), a neurotoxic amino acid produced by cyanobacteria and diatoms, and the ... |
2,325,373 | Clinical correlates of enlarged cavum septum pellucidum in schizophrenia: A revisit through computed tomography. | Like prevalence of abnormal cavum septum pellucidum in patients of schizophrenia remains controversial, its role in clinical outcome, duration of illness and effect on treatment remains less understood as well. Our study examined clinical correlates of enlarged cavum septum pellucidum in schizophrenia. A total of 139 p... |
2,325,374 | Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. | The scarcity of tissue-specific stem cells and the complexity of their surrounding environment have made molecular characterization of these cells particularly challenging. Through single-cell transcriptome and weighted gene co-expression network analysis (WGCNA), we uncovered molecular properties of CD133(+)/GFAP(-) e... |
2,325,375 | The HV3 Score: A New Simple Tool to Suspect Cognitive Impairment in Multiple Sclerosis in Clinical Practice. | Cognitive impairment in multiple sclerosis (MS) is common even in the early stages of the disease. Our objective was to improve early detection of cognitive impairment in MS.</AbstractText>Seventy-five patients with relapsing remitting (RR) MS and 20 controls were enrolled. Two RRMS groups were defined according to the... |
2,325,376 | Large deep white matter lesions may predict futile recanalization in endovascular therapy for acute ischemic stroke. | This study investigated whether large ischemic lesions in the deep white matter (DWM) on pretreatment diffusion-weighted MRI (DWI) predict futile recanalization.</AbstractText>Consecutive acute stroke patients with anterior circulation ischemia who underwent successful arterial recanalization with thrombolysis in cereb... |
2,325,377 | Stress-induced inhibition of LH pulses in female rats: role of GABA in arcuate nucleus. | Stress exerts profound inhibitory effects on reproductive function by suppression of the pulsatile release of GnRH and therefore LH. Besides the corticotrophin-releasing factor (CRF), this effect also might be mediated via GABAergic signaling within the arcuate nucleus (ARC) since its inhibitory effects on LH pulses an... |
2,325,378 | Anatomic features of interest in women at risk of cardiac exposure from whole breast radiotherapy. | Left-sided breast radiotherapy (RT) can result in cardiac exposure. This study aims to identify predictive anatomic features in women requiring breath-hold (RT(BH)) for cardiac sparing during adjuvant whole breast RT.</AbstractText>We retrospectively reviewed free-breathing (FB) CT scans of 80 women previously treated ... |
2,325,379 | Neuropsychological Function in a Case of Dandy-Walker Variant in a 68-Year-Old Veteran. | Dandy-Walker syndrome (DWS) is a congenital brain malformation that is characterized by partial or complete agenesis of the cerebellar vermis and cystic dilatation of the 4th ventricle that shifts ventrolaterally to displace the cerebellar hemispheres. This case is a 68-year-old male veteran with complaints of new-onse... |
2,325,380 | Study of Alzheimer’s Disease Progression In MR Brain Images based on Segmentation and Analysis of Ventricles using Modified DRLSE Method and Minkowski Functionals. | In this work, the ventricles in MR brain images are segmented using edge based modified Distance Regularized Level Set Evolution (DRLSE) method and the structural changes in the disease is further analysed using Minkowski functionals (MFs). Twenty normal and abnormal T1-weighted coronal mid slice MR image are considere... |
2,325,381 | Ependymal Proliferation: A Conduit for Tricking the Central Nervous System into Bioengineering Itself. | Ependymal Cells are a type of Glial Cell lining the ventricles and central canal of the spinal cord. Their primary function is to secrete and circulate cerebrospinal fluid (CSF). Neural stem cells (NSC) exist within the ependymal lining that are capable of neurogenesis. Historically it was thought that neurogenesis onl... |
2,325,382 | Mesh Smoothing Algorithm Applied to a Finite Element Model of the Brain for Improved Brain-Skull Interface. | The brain-skull interface plays an important role in the strain and pressure response of the brain due to impact. In this study, a finite element (FE) model was developed from a brain atlas, representing an adult brain, by converting each 1mm isotropic voxel into a single element of the same size using a custom code de... |
2,325,383 | Profiling of cardiac β-adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome: Comparison with streptozotocin-induced diabetic rats. | Little is known about metabolic syndrome (MetS)-associated cardiomyopathy, especially in relation to the role and contribution of beta-adrenoceptor (β-AR) subtypes. Therefore, we examined the roles of β-AR subtypes in the cardiac function of rats with MetS (MetS group) and compared it with that of rats with... |
2,325,384 | Association of SNP Rs9943582 in APLNR with Left Ventricle Systolic Dysfunction in Patients with Coronary Artery Disease in a Chinese Han GeneID Population.<Pagination><StartPage>e0125926</StartPage><MedlinePgn>e0125926</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e0125926</ELocationID><ELocationID EI... | Heart failure affects 1-2% of the adult population worldwide and coronary artery disease (CAD) is the underlying etiology of heart failure in 70% of the patients. The pathway of apelin and its apelin receptor (APJ) was implicated in the pathogenesis of heart failure in animal models, but a similar role in humans is unk... |
2,325,385 | Cells involved in extracellular matrix remodeling after acute myocardial infarction. | Evaluate the effects of VEGF165 gene transfer in the process of remodeling of the extracellular matrix after an acute myocardial infarct.</AbstractText>Wistar rats were submitted to myocardial infarction, after the ligation of the left descending artery, and the left ventricle ejection fraction was used to classify the... |
2,325,386 | The sexual dimorphism associated with pulmonary hypertension corresponds to a fibrotic phenotype. | Although female predominance in the development of all types of pulmonary hypertension (PH) is well established, many clinical studies have confirmed that females have better prognosis and higher survival rate than males. There is no clear explanation of why sex influences the pathogenesis and progression of PH. Using ... |
2,325,387 | Emerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series). | Reversible lysine acetylation has emerged as a critical mechanism for controlling the function of nucleosomal histones as well as diverse nonhistone proteins. Acetyl groups are conjugated to lysine residues in proteins by histone acetyltransferases and removed by histone deacetylases (HDACs), which are also commonly re... |
2,325,388 | Identifying neuroanatomical signatures of anorexia nervosa: a multivariate machine learning approach. | There are currently no neuroanatomical biomarkers of anorexia nervosa (AN) available to make clinical inferences at an individual subject level. We present results of a multivariate machine learning (ML) approach utilizing structural neuroanatomical scan data to differentiate AN patients from matched healthy controls a... |
2,325,389 | Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 10: Change in ventricle size as a measurement of effective treatment of hydrocephalus. | The objective of this systematic review is to answer the following question: Does ventricle size after treatment have a predictive value in determining the effectiveness of surgical intervention in pediatric hydrocephalus?</AbstractText>The US National Library of Medicine PubMed/MEDLINE database and the Cochrane Databa... |
2,325,390 | Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 4: Cerebrospinal fluid shunt or endoscopic third ventriculostomy for the treatment of hydrocephalus in children. | The objective of this systematic review was to examine the existing literature comparing CSF shunts and endoscopic third ventriculostomy (ETV) for the treatment of pediatric hydrocephalus and to make evidence-based recommendations regarding the selection of surgical technique for this condition.</AbstractText>Both the ... |
2,325,391 | Timing of endoscopic third ventriculostomy in pediatric patients with congenital obstructive hydrocephalus: assessment of neurodevelopmental outcome and short-term operative success rate. | The purpose of this study was to determine the impact of early (⩽6 months old), midterm (6-12 months old) and late (>12 months old) endoscopic third ventriculostomy (ETV) on the operative success rate and postoperative neurodevelopmental outcome of children with congenital obstructive hydrocephalus. We divide... |
2,325,392 | Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier.<Pagination><StartPage>2973</StartPage><EndPage>2982</EndPage><MedlinePgn>2973-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.... | Peculiarities of longitudinal shift of the left ventricle (LV) walls were studied in patients in various variants of dilated cardiomyopathy (DCMP). In patients, suffering DCMP, the enhancement of the end-diastolic (EDI) and the end-systolic (ESI) indexes are noted, as well as of the punch index and expulsion fraction, ... |
2,325,393 | The Root Extract of Gentiana macrophylla Pall. Alleviates Cardiac Apoptosis in Lupus Prone Mice. | The roots of the perennial herb Gentiana macrophylla Pall. (GM) are known as Qinjiao, which has been used for centuries to treat systemic lupus erythematosus (SLE). However, little is known about the effects of GM on cholesterol-aggravated cardiac abnormalities in SLE, and the mechanisms thereof. This study investigate... |
2,325,394 | Focal mid-ventricular anterior ballooning: An unusual pattern of Takotsubo cardiomyopathy. | Takotsubo cardiomyopathy (TC) or left ventricular apical ballooning syndrome is typically characterized by reversible systolic dysfunction of the apical- and mid-segments of the left ventricle. Symptoms are precipitated by intense emotional or physical stress, in the absence of obstructive coronary artery lesions. The ... |
2,325,395 | Aqueductal Stenosis Has a New Dimension--Aspergillosis: A Rare Case Report and Review of the Literature. | Cerebral aspergillosis, often encountered in immunocompromised patients, is almost always fatal despite radical surgical and medical management and frequently is a finding at autopsy. Attempts at fungal isolation often are unsuccessful, and a high index of radiologic suspicion is necessary.</AbstractText>A premature, 5... |
2,325,396 | Comparison of myocardial F-18 FDG uptake between overnight and non-overnight fasting in non-diabetic healthy subjects. | To evaluate whether an overnight or non-overnight fast for suppressing physiological FDG uptake by the myocardium is better in non-diabetic healthy subjects before F-18 FDG PET/CT studies.</AbstractText>One hundred two subjects who underwent whole-body F-18 FDG PET/CT for routine health checkups were retrospectively re... |
2,325,397 | Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. | Cerebrospinal fluid (CSF) includes conserved factors whose function is largely unexplored. To assess the role of CSF during embryonic development, CSF was repeatedly drained from embryonic zebrafish brain ventricles soon after their inflation. Removal of CSF increased cell death in the diencephalon, indicating a surviv... |
2,325,398 | Factors affecting the evacuation rate of intracerebral hemorrhage in basal ganglia treated by minimally invasive craniopuncture.<Pagination><StartPage>104</StartPage><EndPage>109</EndPage><MedlinePgn>104-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clineuro.2015.04.020</ELocationID><ELoca... | Minimally invasive craniopuncture has been used to treat intracerebral hemorrhage (ICH) for over 20 years in China. However, one-off total evacuation of hematoma cannot be achieved through this procedure because it is not an open surgery. This study is designed to identify factors that can increase the hematoma evacuat... |
2,325,399 | Brain malformations in a patient with deletion 2p16.1: A refinement of the phenotype to BCL11A. | Microdeletions of 2p15-16.1 have been reported in 15 patients with a recognizable syndrome of dysmorphic features, intellectual disability and microcephaly. Facial features include telecanthus, short palpebral fissures, epicanthal folds, a broad nasal root, smooth and long philtrum and large ears. Brain malformations c... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.