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2,328,100 | N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing brain. | The etiology of neurological impairments associated with prematurity and other perinatal complications often involves an infectious or pro-inflammatory component. The use of antioxidant molecules have proved useful to protect the neonatal brain from injury. The choroid plexuses-CSF system shapes the central nervous sys... |
2,328,101 | 3D Hermite Transform Optical Flow Estimation inLeft Ventricle CT Sequences. | Heart diseases are the most important causes of death in the world and over the years, thestudy of cardiac movement has been carried out mainly in two dimensions, however, it is important toconsider that the deformations due to the movement of the heart occur in a three-dimensional space.The 3D + t analysis allows to d... |
2,328,102 | Neuroinflammation and Neurogenesis in Alzheimer's Disease and Potential Therapeutic Approaches. | In adult brain, new neurons are generated throughout adulthood in the subventricular zone and the dentate gyrus; this process is commonly known as adult neurogenesis. The regulation or modulation of adult neurogenesis includes various intrinsic pathways (signal transduction pathway and epigenetic or genetic modulation ... |
2,328,103 | Developmental dynamics of the periventricular parietal crossroads of growing cortical pathways in the fetal brain - In vivo fetal MRI with histological correlation. | The periventricular crossroads have been described as transient structures of the fetal brain where major systems of developing fibers intersect. The triangular parietal crossroad constitutes one major crossroad region. By combining in vivo and post-mortem fetal MRI with histological and immunohistochemical methods, we... |
2,328,104 | Lobar holoprosencephaly with craniofacial defects in a Friesian calf: A case report. | Holoprosencephaly is a forebrain deformity that results from varying degrees of separation failure of cerebral hemispheres. The condition is classified based on the degree of non-separation of the hemispheres which, in turn, determines its severity. Holoprosencephaly is usually accompanied by craniofacial defects ... |
2,328,105 | Temperature-Controlled Radiofrequency Ablation Using Irrigated Catheters: Maximizing Ventricular Lesion Dimensions While Reducing Steam-Pop Formation. | The goal of this study was to examine the safety and efficacy of radiofrequency ablation (RFA) with irrigated catheters operated in a temperature-controlled mode for ventricular ablation.</AbstractText>Techniques to increase RFA dimensions are associated with higher risk for steam-pops. A novel irrigated catheter with ... |
2,328,106 | 7T MRI Predicts Amelioration of Neurodegeneration in the Brain after AAV Gene Therapy. | GM1 gangliosidosis (GM1) is a fatal neurodegenerative lysosomal storage disease that occurs most commonly in young children, with no effective treatment available. Long-term follow-up of GM1 cats treated by bilateral thalamic and deep cerebellar nuclei (DCN) injection of adeno-associated virus (AAV)-mediated gene thera... |
2,328,107 | A Novel Deep Learning Approach with a 3D Convolutional Ladder Network for Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus and Alzheimer's Disease. | Idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) are geriatric diseases and common causes of dementia. Recently, many studies on the segmentation, disease detection, or classification of MRI using deep learning have been conducted. The aim of this study was to differentiate iNPH and AD using... |
2,328,108 | [Protective effects and mechanisms of Xingnaojing Injection on early global brain ischemic-induced deep coma in rats]. | To study the protective effect of Xingnaojing Injection on early global brain ischemia-induced deep coma in rats.
 Methods: The deep coma model was induced by global brain ischemia by using four-vessel occlusion method in male SD rats. According to the body weight, the rats were randomly divided into 8 groups: a... |
2,328,109 | Swift Spontaneous Regression of a Pediatric Traumatic Acute Subdural Hematoma. | We report the case of a 4-year-old girl with acute subdural hematoma who presented to the emergency department after an unwitnessed fall of the balcony. The hematoma was hyperdense along the left convexity of 9 mm thickness with a consequent mass effect with obliteration of the adjacent sulci, left lateral ventricle co... |
2,328,110 | Taking pigeons to heart: Birds proficiently diagnose human cardiac disease. | In two experiments, we trained pigeons (Columba livia) to sort visual images (obtained by clinical myocardial perfusion imaging techniques) depicting different degrees of human cardiac disfunction (myocardial hypoperfusion of the left ventricle) into normal and abnormal categories by providing food reward only after co... |
2,328,111 | Cranial and ventricular size following shunting or endoscopic third ventriculostomy (ETV) in infants with aqueductal stenosis: further insights from the International Infant Hydrocephalus Study (IIHS). | The craniometrics of head circumference (HC) and ventricular size are part of the clinical assessment of infants with hydrocephalus and are often utilized in conjunction with other clinical and radiological parameters to determine the success of treatment. We aimed to assess the effect of endoscopic third ventriculosto... |
2,328,112 | Anisotropic conduction in the myocardium due to fibrosis: the effect of texture on wave propagation. | Cardiac fibrosis occurs in many forms of heart disease. It is well established that the spatial pattern of fibrosis, its texture, substantially affects the onset of arrhythmia. However, in most modelling studies fibrosis is represented by multiple randomly distributed short obstacles that mimic only one possible textur... |
2,328,113 | Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia. | Chronic hypoxia from diseases in the lung, such as pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease, can increase pulmonary vascular resistance, resulting in hypertrophy and dysfunction of the right ventricle (RV). In order to obtain insight into RV biology and perhaps uncover poten... |
2,328,114 | [Using the FOCUS Family Intervention for Family-Centered Care in a Premature Infant With Grade IV Intraventricular Hemorrhage]. | Preterm infants face increased rates of mortality and developmental complications, which are a burden on children's parents (and caregivers), who suffer from exhaustion and situational uncertainty. This case focused on an extremely-low-birth-weight (908 gm) premature infant with initial unstable vital signs complicated... |
2,328,115 | Long-Term Outcomes of Endoscopic Third Ventricle Colloid Cyst Resection: Case Series With a Proposed Grading System. | Endoscopic resection of colloid cysts has gained recent widespread practice. However, reported complication and recurrence rates are variable, possibly, in part, because of a lack of consistency with reporting of the extent of cyst capsule removal.</AbstractText>To present the long-term outcomes of endoscopic resection... |
2,328,116 | Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus. | Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular r... |
2,328,117 | Percutaneous Mechanical Unloading Simultaneously With Reperfusion Induces Increased Myocardial Salvage in Experimental Acute Myocardial Infarction. | Despite advances in reperfusion times, patients presenting with acute myocardial infarction carry an unacceptably high rate of mortality and morbidity. Mechanical unloading of the left ventricle (LV) has been suggested to reduce infarct size after acute myocardial infarction. Although prior studies have investigated LV... |
2,328,118 | Multisite pacing and myocardial scars: a computational study. | Cardiac resynchronization therapy (CRT) is a frequently effective treatment modality for dyssynchronous heart failure, however, 30% of patients do not respond, usually due to suboptimal activation of the left ventricle (LV). Multisite pacing (MSP) may increase the response rate, but its effect in the presence of myocar... |
2,328,119 | Blended phenotype of AP4E1 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15. | Atypical phenotype of an imprinting disease can develop with a recessive homozygous variant due to uniparental isodisomy. We present a girl with severe intellectual disability, developmental delay, distinctive facial features, and other neuropsychiatric features. Trio whole exome sequencing revealed a novel homozygous ... |
2,328,120 | Efficient estimation of load-free left ventricular geometry and passive myocardial properties using principal component analysis. | Models of cardiac mechanics require a well-defined reference geometry from which deformations and hence myocardial strain and stress can be calculated. In the in vivo beating heart, the load-free (LF) geometry generally cannot be measured directly, since, in many cases, there is no stage at which the lumen pressures an... |
2,328,121 | Fully automated segmentation of left ventricular scar from 3D late gadolinium enhancement magnetic resonance imaging using a cascaded multi-planar U-Net (CMPU-Net). | Three-dimensional (3D) late gadolinium enhancement magnetic resonance (LGE-MR) imaging enables the quantification of myocardial scar at high resolution with unprecedented volumetric visualization. Automated segmentation of myocardial scar is critical for the potential clinical translation of this technique given the nu... |
2,328,122 | Tremor Caused by Dandy-Walker Syndrome Concomitant with Syringomyelia: Case Report and Review of the Literature Review. | Dandy-Walker Syndrome (DWS) is a rare congenital brain malformation characterized by underdevelopment of cerebellar vermis and cystic enlargement of the fourth ventricle and enlargement of the posterior fossa. The cooccurrence of DWS and syringomyelia in adults is very rare.</AbstractText>We report a man aged 19 years ... |
2,328,123 | Risk Factors for Early Mortality Among Patients with Glioma: A Population-Based Study. | The present study evaluated the early death and factors associated with early mortality in patients with glioma.</AbstractText>The data used for analysis in the present study was extracted from the Surveillance, Epidemiology, and End Results data set.</AbstractText>A total of 58,700 patients with glioma were enrolled i... |
2,328,124 | Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia. | Recent findings describe microglia as modulators of neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are thought to adopt a neurotrophic phenotype after ischemic stroke. Early postnatal microglia are endogenously activated and may therefore exhibit an increased sensitivity to neonatal hypox... |
2,328,125 | Factors associated with the development and outcome of hydrocephalus after decompressive craniectomy for traumatic brain injury. | Posttraumatic hydrocephalus (PTH) is common in patients undergoing decompressive craniectomy (DC) for traumatic brain injury (TBI), but the incidence, mechanisms, and risk factors have not been fully elucidated. This study aimed to determine the incidence of and the factors associated with PTH. We retrospectively revie... |
2,328,126 | Dysregulation of Notch signaling in cardiac mesenchymal cells of patients with tetralogy of Fallot.<Pagination><StartPage>38</StartPage><EndPage>47</EndPage><MedlinePgn>38-47</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41390-020-0760-6</ELocationID><Abstract><AbstractText Label="BACKGROUND"... | The decisive role Dr. Harvey Cushing (1869-1939) played in medicine goes far beyond the development of neurosurgery. His scientific devotion and commitment to patient care made him an ethical model of strict professionalism. This paper seeks to analyze the decisions Cushing made with the challenging case of HW, an adol... |
2,328,127 | Simultaneous Tissue Classification and Lateral Ventricle Segmentation via a 2D U-net Driven by a 3D Fully Convolutional Neural Network. | In this paper, we proposed and validated a novel and fully automatic pipeline for simultaneous tissue classification and lateral ventricle segmentation via a 2D U-net. The 2D U-net was driven by a 3D fully convolutional neural network (FCN). Multiple T1-weighted atlases which had been pre-segmented into six whole-brain... |
2,328,128 | Two-Element Fractional-Order Windkessel Model to Assess the Arterial Input Impedance. | Arterial system is completely coupled with the heart, such that the contractile state of the left ventricle and its produced central blood pressure (the pressure in the aorta) are in tune with the arterial mechanical properties. This study investigates the use of fractional-order capacitor and resistor elements to expo... |
2,328,129 | Deep CNN with LM learning based myocardial ischemia detection in cardiac magnetic resonance images. | Cardiovascular disease (CVD) is a chronic dysfunction caused by deterioration in cardiac physiology. It results in about 31% of mortality worldwide. Among CVDs, myocardial ischemia (MI) leads to restriction in blood supply to heart tissues. There is a need to develop an effective computer aided detection (CAD) system t... |
2,328,130 | Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties. | Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a powerful platform for in vitro modelling of cardiac diseases, safety pharmacology and drug screening. All these applications require large quantities of well-characterised and standardised batches of hiPSC-CMs. Cryopreservation of ... |
2,328,131 | Explainable Anatomical Shape Analysis Through Deep Hierarchical Generative Models. | Quantification of anatomical shape changes currently relies on scalar global indexes which are largely insensitive to regional or asymmetric modifications. Accurate assessment of pathology-driven anatomical remodeling is a crucial step for the diagnosis and treatment of many conditions. Deep learning approaches have re... |
2,328,132 | A critical appraisal of Monro's erroneous description of the cerebral interventricular foramina: Age-related magnetic resonance imaging spatial morphometry and a proposed new terminology. | Anatomic connections between the cerebral lateral and third ventricles have been mischaracterized since Monro's original erroneous description of his eponymous foramina (FoMs) as being only one T-shaped passage. Accurate knowledge of the in vivo three-dimensional (3D) configuration of FoM has important clinical neuroen... |
2,328,133 | Akhirin regulates the proliferation and differentiation of neural stem cells/progenitor cells at neurogenic niches in mouse brain. | Specialized microenvironment, or neurogenic niche, in embryonic and postnatal mouse brain plays critical roles during neurogenesis throughout adulthood. The subventricular zone (SVZ) and the dentate gyrus (DG) of hippocampus in the mouse brain are two major neurogenic niches where neurogenesis is directed by numerous r... |
2,328,134 | Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos. | The sodium osmotic gradient is necessary for the initiation of brain ventricle inflation, but a previous study predicted that organic and inorganic osmolytes play equivalently important roles in osmotic homeostasis in astrocytes. To test whether organic osmoregulation also plays a role in brain ventricle inflation, the... |
2,328,135 | Timely-Automatic Procedure for Estimating the Endocardial Limits of the Left Ventricle Assessed Echocardiographically in Clinical Practice. | In this paper, we propose an analytical rapid method to estimate the endocardial borders of the left ventricular walls on echocardiographic images for prospective clinical integration. The procedure was created as a diagnostic support tool for the clinician and it is based on the use of the anisotropic generalized Houg... |
2,328,136 | Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent. | Uroguanylin (UGN) is released from the intestine after a meal. When applied in brain ventricles, UGN increases expression of markers of thermogenesis in brown adipose tissue (BAT). Therefore, we determine the effects of its receptor, guanylate cyclase C (GC-C), on mouse interscapular BAT (iBAT) activity during diet-ind... |
2,328,137 | Postnatal Intracranial Findings Following Fetal Repair of Spinal Dysraphisms. | Our objective is to document the imaging appearance in the intracranial compartment at the time of the infants' first postnatal brain MR imaging after fetal repair for spinal dysraphisms.</AbstractText>Twenty-nine patients were evaluated on fetal and postnatal magnetic resonance imaging for a series of features of Chia... |
2,328,138 | p-Chloroamphetamine-Enhanced Neostriatal Dopamine Exocytosis in Rats Neonatally Co-lesioned with 6-OHDA and 5,7-DHT: Relevance to Parkinson's Disease. | Serotoninergic nerves are known to modulate sensitization of dopamine receptors (DA-R) in a rodent model of Parkinson's disease (PD). However, serotoninergic nerves are not known to have a prominent role on DA exocytosis in intact rats. The current study was undertaken to explore the possible influence of serotoninergi... |
2,328,139 | TLR4/MyD88/NF-κB-Mediated Inflammation Contributes to Cardiac Dysfunction in Rats of PTSD. | Post-traumatic stress disorder (PTSD) is related with myocardial injury and cardiac dysfunction, while the molecular mechanism has not been clear. This study investigated whether TLR4/MyD88/NF-κB-mediated inflammation involved in myocardial injury of PTSD. Adult male Wistar rats were exposed to single-prolonged s... |
2,328,140 | Cystic Glioblastoma Rupturing into the Ventricle. | Cystic tumors, such as craniopharyngiomas and Rathke's cleft cysts, as well as arachnoid cysts have been reported to rupture occasionally. Approximately 8-10% of glioblastomas (GBMs) are known to have a significant cystic component; however, to the best of our knowledge, no studies have reported cystic rupturing of GBM... |
2,328,141 | Incidental Follow-up Imaging of Previous Ventricular Tuberculosis and Pneumoencephalography in a 57-year-old man. | We present a rare case of follow-up by neuroimaging in a 57-year-old man with a previous pneumoencephalography to evaluate ventricular tuberculosis (TB). Magnetic resonance imaging (MRI) of the whole head was performed at 3T using T1-weighted magnetization-prepared rapid gradient echo (T1-MPRAGE). A full quantitat... |
2,328,142 | Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study. | Obstructive sleep apnea (OSA), although a growing healthcare problem and documented risk factor for cardiovascular diseases, is still under-diagnosed in cardiac patients. To investigate the correlation between OSA and echocardiographic parameters of right ventricle diastolic (RVD) dysfunction, in particular trans-tricu... |
2,328,143 | Oxytocin receptor antagonist reverses the blunting effect of pair bonding on fear learning in monogamous prairie voles. | Social relationships among spouses, family members, and friends are known to affect physical and mental health. In particular, long-lasting bonds between socio-sexual partners have profound effects on cognitive, social, emotional, and physical well-being. We have previously reported that pair bonding in monogamous prai... |
2,328,144 | [Retroperitoneal fetus in fetu]. | Fetus in Fetu (FIF) is an extremely rare congenital anomaly defined as a mass containing a vertebral axis often associated with other organs or limbs around this axis. We report the case of a female fetus aged 4 months presenting with retroperitoneal mass measuring 7x6x4cm, suggesting teratoma on computerized tomograph... |
2,328,145 | Pleomorphic xanthoastrocytoma inside lateral ventricle: a rare case report and literature review. | Pleomorphic xanthoastrocytoma (PXA) is a relatively rare, low grade astrocytic tumor that usually affects children as well as young adults. The reported cases were predominantly located superficially in the temporal lobe. To our knowledge, so far only two cases of PXA occurring in lateral ventricle were reported in Eng... |
2,328,146 | Third ventricle tumor with Bruns sign as the first manifestation: a case report. | This article reported a case of a third ventricle tumor with Bruns syndrome sudden disturbance of consciousness as the first manifestation, to improve the clinician's understanding and awareness of the fatal signs. A 38-year-old healthy man was admitted to our hospital for a sudden onset coma for 2 hours. Head magnetic... |
2,328,147 | Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study. | Both aging and changes in blood flow velocity between the extracranial (intraspinal) and intracranial regions of cerebral vessels have an impact on brain hydro-hemodynamics. Arterial and venous cerebral blood flows interact with cerebrospinal fluid (CSF) in the both the cranial and spinal systems. Studies suggest that ... |
2,328,148 | New Insights into the Anterior Complex. | To introduce visualization of the germinal matrix (GM), external angle of the frontal horn, and periventricular white matter while evaluating the anterior complex (AC) during basic ultrasound assessment of the fetal brain.</AbstractText>This is a retrospective observational study of healthy women with singleton pregnan... |
2,328,149 | Characteristics and Outcomes of Patients Presenting With Hypertensive Urgency in the Office Setting: The Campania Salute Network. | Hypertensive urgencies (HypUrg) are defined as severe elevation in blood pressure (BP) without acute target organ damage. In the office setting, treated asymptomatic patients, with severe BP elevation meeting criteria for urgency are often seen. We evaluate incident Cardiovascular (CV) events (n = 311) during follow-up... |
2,328,150 | Immunohistochemical and histological evaluations of cyclophosphamide-induced acute cardiotoxicity in wistar rats: The role of turmeric extract (curcuma). | Chemotherapy-induced cardiac derangement is a major concern in health sector. Cyclophosphamide as a chemotherapeutic agent induces acute cardiotoxicity through its toxic metabolite, acrolein. This study evaluated the effect of ethanol extract of turmeric on cyclophosphamide-induced acute cardiotoxicity in Wistar rats. ... |
2,328,151 | Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium. | Stem cell transplantation has been limited by poor survival of the engrafted cells in hostile microenvironment of the infarcted myocardium. This study investigated cytoprotective effect of rapamycin-preactivated autophagy on survival of the transplanted mesemchymal stem cells (MSCs). MSCs isolated from rat bone marrow ... |
2,328,152 | Cyst fenestration and Ommaya reservoir placement in endoscopic transcortical transventricular approach for recurrent suprasellar cystic craniopharyngioma without ventriculomegaly. | The efficacy of the endoscopic transcortical transventricular approach (ETTA) for craniopharyngioma in the third ventricle with hydrocephalus has been reported focusing on its reduced invasiveness. On the other hand, suprasellar craniopharyngioma without ventriculomegaly is generally surgically managed by craniotomy or... |
2,328,153 | Dedicated diffusion phantoms for the investigation of free water elimination and mapping: insights into the influence of T<sub>2</sub> relaxation properties. | Conventional diffusion-weighted (DW) MRI suffers from free water contamination due to the finite voxel size. The most common case of free water contamination occurs with cerebrospinal fluid (CSF) in voxels located at the CSF-tissue interface, such as at the ventricles in the human brain. Another case refers to intra-ti... |
2,328,154 | High-Resolution MRI for Evaluation of Ventriculostomy Tubes: Assessment of Positioning and Proximal Patency. | Imaging evaluation of ventriculostomy tubes, despite the frequency of malfunction, has remained inadequate due to the absence of a systematic way of assessing the catheter itself. In this retrospective review, we assessed the utility of high-resolution 3D MR imaging techniques, including CISS and volumetric interpolate... |
2,328,155 | [Clinical and genetic analysis of an infant with Lowe syndrome caused by exonic duplication of OCRL gene]. | To explore the genetic basis of an infant featuring congenital cataract, developmental delay and proteinuria.</AbstractText>Clinical data and peripheral blood samples of the family were collected. Potential variants were screened by using targeted capture and high-throughput sequencing on a NextSeq 500 platform. Suspec... |
2,328,156 | Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model. | Microglia and astrocytes can quench metal toxicity to maintain tissue homeostasis, but with age, increasing glial dystrophy alongside metal dyshomeostasis may predispose the aged brain to acquire neurodegenerative diseases. The aim of the present study was to investigate age-related changes in brain metal deposition al... |
2,328,157 | Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy. | Adult neurogenesis, the production of newborn neurons from neural stem cells (NSCs) has been suggested to be decreased in patients with schizophrenia. A similar finding was observed in an animal model of schizophrenia, as indicated by decreased bromodeoxyuridine (BrdU) labelling cells in response to a non-competitive N... |
2,328,158 | EphrinB/EphB Signaling Contributes to the Synaptic Plasticity of Chronic Migraine Through NR2B Phosphorylation. | The specific mechanism of migraine chronification remains unclear. We previously demonstrated that synaptic plasticity was associated with migraine chronification. EphB receptors and their ligands, ephrinBs, are considered to be key molecules regulating the synaptic plasticity of the central nervous system. However, wh... |
2,328,159 | A Rapid Development of a Right Ventricular Aneurysm Postmyocardial Infarction.<Pagination><StartPage>1377</StartPage><EndPage>1379</EndPage><MedlinePgn>1377-1379</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1053/j.jvca.2019.12.006</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1053-0770(19)3... | Myocardial infarctions may cause ventricular aneurysms. Ischemia-induced ventricular changes are more common in the left ventricle owing to the larger vascular supply, greater volume of myocardium, and increased intra-ventricular pressure. Ischemia-induced right ventricular free wall abnormalities are rare owing to the... |
2,328,160 | Wenxin Granules Influence the TGF<i>β</i>-P38/JNK MAPK Signaling Pathway and Attenuate the Collagen Deposition in the Left Ventricle of Myocardial Infarction Rats. | A large number of proinflammatory/anti-inflammatory cytokines are produced in the extracellular matrix (ECM) after myocardial infarction (MI), and the inflammatory pathways activated by these inflammatory stimuli are involved in the regulation of lesions with excessive accumulation of ECM. Wenxin granules can play a pr... |
2,328,161 | Functional herniated choroid plexus in brain parenchyma following VP shunt removal. | We report a 4-year-old male who presented with a blocked ventriculoperitoneal (VP) shunt inserted post excision of a WHO Grade 1 cerebellar pilocytic astrocytoma complicated post-operatively by pseudo meningocoele formation. Imaging revealed choroid plexus that had herniated along the shunt tract. Subsequent MRI showed... |
2,328,162 | Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity. | Children surviving cancer and chemotherapy are at risk for adverse health events including heart failure that may be delayed by years. Although the early effects of doxorubicin-induced cardiotoxicity may be attributed to a direct effect on the cardiomyocytes, the mechanisms underlying the delayed or late effects (8-20 ... |
2,328,163 | Evaluation of changes in magnetic resonance diffusion tensor imaging after treatment of delayed encephalopathy due to carbon monoxide poisoning. | Diffusion tensor imaging of the brain tissue microstructure was performed to predict or diagnose the pathophysiological mechanism underlying delayed encephalopathy after carbon monoxide poisoning and the treatment effect was analyzed. The changes in the diffusion parameters (average diffusion coefficient and fractional... |
2,328,164 | MR-Brain Causing Confusion. | This is a T2 weighted image (T2WI). In T2WI compartments filled with fluid appear brighter (as is the case of the CSF in the lateral ventricles). On the contrary, tissues with a high fat content appear as dark. This T2WI demonstrates layering of debris (figure 2- marked red star) in the occipital horn of the lateral ve... |
2,328,165 | MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure. | A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. Alternative splicing of MEF2C exons α, β and γ provides transcript diversity with gene activation or repression functionalities.</AbstractText>Neo... |
2,328,166 | Melanin-concentrating hormone (MCH) in the median raphe nucleus: Fibers, receptors and cellular effects. | Serotonergic neurons of the median raphe nucleus (MnR) and hypothalamic melanin-concentrating hormone (MCH)-containing neurons, have been involved in the control of REM sleep and mood. In the present study, we examined in rats and cats the anatomical relationship between MCH-containing fibers and MnR neurons, as well a... |
2,328,167 | Determination of the theoretical personalized optimum chest compression point using anteroposterior chest radiography. | There is a traditional assumption that to maximize stroke volume, the point beneath which the left ventricle (LV) is at its maximum diameter (P_max.LV) should be compressed. Thus, we aimed to derive and validate rules to estimate P_max.LV using anteroposterior chest radiography (chest_AP), which is performed for critic... |
2,328,168 | Adult Neurogenesis in the Context of Brain Repair and Functional Relevance. | Urodeles and some fishes possess a remarkable capacity to regenerate their limbs/fins, a property that correlates with their additional ability to regenerate large areas of the brain and/or produce a variety of new neurons during adulthood. In contrast, neurogenesis in adult mammals is apparently restricted to two main... |
2,328,169 | Unilateral Open-lip Schizencephaly with Tonsillar Herniation in a Preterm Infant. | Schizencephaly is a rare type of neuronal migration disorder characterized by the presence of a cerebral hemispheric cleft that extends from lateral ventricles to the cortical surface of the brain. We report a rare case of prenatally diagnosed unilateral schizencephaly in a late preterm infant who manifested with rapid... |
2,328,170 | Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats. | Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but it has also been shown to exhibit strong antioxidative, anti-inflammatory, and neuroprotective effects. H... |
2,328,171 | Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report. | Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 mont... |
2,328,172 | Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart. | RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional control of gene expression in several pathophysiological conditions. Diabetes adversely affects monocyte/macrophage biology and function. It is not known whether diabetic milieu affects cellular/exosome-HuR and its implications o... |
2,328,173 | A case of developing obstructive hydrocephalus following aqueductal stenosis caused by developmental venous anomalies. | Developmental venous anomalies (DVAs), previously also known as venous angiomas, are variations of normal trans-medullary veins draining from white and gray matter. DVAs are usually asymptomatic and mostly discovered incidentally on brain imaging. However, some studies have reported symptomatic cases associated with DV... |
2,328,174 | Radial Glial Cell-Derived VCAM1 Regulates Cortical Angiogenesis Through Distinct Enrichments in the Proximal and Distal Radial Processes. | Angiogenesis in the developing cerebral cortex accompanies cortical neurogenesis. However, the precise mechanisms underlying cortical angiogenesis at the embryonic stage remain largely unknown. Here, we show that radial glia-derived vascular cell adhesion molecule 1 (VCAM1) coordinates cortical vascularization through ... |
2,328,175 | Genetic disruption of slc4a10 alters the capacity for cellular metabolism and vectorial ion transport in the choroid plexus epithelium. | Genetic disruption of slc4a10, which encodes the sodium-dependent chloride/bicarbonate exchanger Ncbe, leads to a major decrease in Na+</sup>-dependent HCO3</sub>-</sup> import into choroid plexus epithelial cells in mice and to a marked reduction in brain intraventricular fluid volume. This suggests that Ncbe function... |
2,328,176 | Prediction of Left Ventricular Mechanics Using Machine Learning. | The goal of this paper was to provide a real-time left ventricular (LV) mechanics simulator using machine learning (ML). Finite element (FE) simulations were conducted for the LV with different material properties to obtain a training set. A hyperelastic fiber-reinforced material model was used to describe the passive ... |
2,328,177 | Cavernoma of the Right Lateral Ventricle: A Rare Case Report. | Intraventricular cavernoma (IVC) is a rare pathological entity constituting 2.5%-10.8% of cerebral cavernomas. The lateral ventricles are the most frequent site, followed by the third and fourth ventricles. IVCs usually attain a large size compared to parenchymal cavernomas and cause signs and symptoms mainly due to ma... |
2,328,178 | Prenatal diagnosis of foetal hydrocephalus and suspected X-linked recessive inheritance of cleft lip in a Chihuahua. | A 3.5-year-old, 2.9 kg, multiparous Chihuahua presented with abdominal distension; pregnancy was diagnosed. On Day 7 before parturition, prenatal sonograms showed anechoic bilateral dilated cerebral lateral ventricles, suggesting fluid-filled regions (ventriculomegaly) in one foetus. A Caesarean section was performed a... |
2,328,179 | Ependymal cells in the spinal cord as neuronal progenitors. | Ependymal cells are neural progenitors and form part of the central canal of the spinal cord. Therefore, ependymal cells could serve as a potential source of neural progenitors for regenerative medicine applications. Such applications consist of endogenous activation or exogenous transplantation, alone or in combinatio... |
2,328,180 | Untangling human neurogenesis to understand and counteract brain disorders. | Neurogenesis in the human postnatal brain occurs in two regions, the subventricular zone of the later ventricle and the dentate gyrus of the hippocampus. While it is well accepted that SVZ and hippocampal neurogenesis are active during juvenile stages in human, their contribution during adulthood and ageing as well as ... |
2,328,181 | DeepCQ: Deep multi-task conditional quantification network for estimation of left ventricle parameters. | Automatic cardiac left ventricle (LV) quantification plays an important role in assessing cardiac function. Although many advanced methods have been put forward to quantify related LV parameters, automatic cardiac LV quantification is still a challenge task due to the anatomy construction complexity of heart.</Abstract... |
2,328,182 | Is This Truly A "Leave-Me-Alone" Lesion? An Unusual Case of Multiple Ring-shaped Lateral Ventricular Nodules. | Ring-shaped lateral ventricular nodules (RSLVNs) are commonly considered as benign asymptomatic lesions, which are sporadically detected as incidental findings on routine brain magnetic resonance imaging scans. Despite their not irrelevant frequency, the exact biological nature of these lesions remains largely unknown ... |
2,328,183 | The implications of hippocampal neurogenesis in adolescent rats after status epilepticus: a novel role of notch signaling pathway in regulating epileptogenesis. | Seizure-induced neurogenesis has a widely recognized pro-epileptogenic function. Given the critical role of Notch signaling during the maintenance and neurogenesis of neural stem cells, we hypothesized that Notch may affect epileptogenesis and its progression through its role in neurogenesis in the adolescent rat brain... |
2,328,184 | Comparison of the beta-hydroxybutyrate, glucose, and lactate concentrations derived from postmortem proton magnetic resonance spectroscopy and biochemical analysis for the diagnosis of fatal metabolic disorders.<Pagination><StartPage>603</StartPage><EndPage>612</EndPage><MedlinePgn>603-612</MedlinePgn></Pagination><ELo... | The detection and quantification of metabolites relevant for the diagnosis of fatal metabolic disorders by proton magnetic resonance spectroscopy (1H-MRS) was recently demonstrated. This prospective study aimed to compare the concentrations of beta-hydroxybutyrate (BHB), glucose (GLC), and lactate (LAC) derived from bo... |
2,328,185 | Developmental aspects of FXAND in a man with the FMR1 premutation. | Fragile X mental retardation 1 (FMR1) premutation can cause developmental problems including autism spectrum disorder (ASD), social anxiety, depression, and attention deficit hyperactivity disorder (ADHD). These problems fall under an umbrella term of Fragile X-associated Neuropsychiatric Disorders (FXAND) and is separ... |
2,328,186 | Interhemispheric Transcallosal Approach for Resection of Choroidal Arteriovenous Malformation: Operative Video. | Choroidal arteriovenous malformations (AVMs) are rare vascular entities located deep within the brain and in close relationship with vital paraventricular structures.<sup>1</sup><sup>,</sup><sup>2</sup> Recruitment of feeders from the anterior and posterior choroidal arteries is typical in these lesions.<sup>3</sup> We... |
2,328,187 | Deformational changes after convection-enhanced delivery in the pediatric brainstem. | In the brainstem, there are concerns regarding volumetric alterations following convection-enhanced delivery (CED). The relationship between distribution volume and infusion volume is predictably greater than one. Whether this translates into deformational changes and influences clinical management is unknown. As part ... |
2,328,188 | Endoscopic third ventriculostomy for pediatric tumor-associated hydrocephalus. | Surgical options for managing hydrocephalus secondary to CNS tumors have traditionally included ventriculoperitoneal shunting (VPS) when tumor resection or medical management alone are ineffective. Endoscopic third ventriculostomy (ETV) has emerged as an attractive treatment strategy for tumor-associated hydrocephalus ... |
2,328,189 | A Rare Instance of Chordoid Glioma With Large Calcification Mimicking Craniopharyngioma. | Chordoid glioma (CG) is a world health organization classified grade II tumor whose typical localization is in the anterior part of the third ventricle. It's clinical, neuroimaging, and pathologic features may vary and furthermore mimic other types of benign lesions usually associated with a better outcome, thus repres... |
2,328,190 | Diffusion magnetic resonance imaging-derived free water detects neurodegenerative pattern induced by interferon-γ. | Imaging biomarkers for immune activation may be valuable for early-stage detection, therapeutic testing, and research on neurodegenerative conditions. In the present study, we determined whether diffusion magnetic resonance imaging-derived free water signal is a sensitive marker for neuroinflammatory effects of interfe... |
2,328,191 | [Adipsic diabetes insipidus patient in postoperative pituitary macroadenoma]. | Adipsic diabetes insipidus is a rare condition secondary to injury to osmoreceptors in the anterior hypothalamic area. Only two cases have been published secondary to pituitary tumor surgery.</AbstractText>A 43-year-old man, postoperative of a non-functioning pituitary macroadenoma invading the third ventricle and comp... |
2,328,192 | Pathological structural changes in the brain in the course of neurocysticercosis - pathogenesis, serological diagnostics and imaging: a literature review. | Neurocysticercosis is one of the most common parasitic diseases of the brain, it is caused by Taenia solium. Human infection occurs as a result of the ingestion of parasite eggs or undercooked pork. Most infections are recorded in endemic regions, i.e.: South America, Asia, India, Africa, China and Nepal. In cysticerco... |
2,328,193 | A curious case of disseminated cysticercosis in an immunocompetent adult. | Cysticercosis is an infection with the larval stage of <i>Taenia Solium</i> which is estimated to affect over 50 million people worldwide. We report a case of disseminated cysticercosis in an immunocompetent 68-year-old male who presented with back pain, presumed to be musculoskeletal in nature initially. Magnetic-reso... |
2,328,194 | Non-invasive quantification of cardiac stroke volume in the edible crab <i>Cancer pagurus</i>.<Pagination><StartPage>46</StartPage><MedlinePgn>46</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">46</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12983-019-0344-7</ELocationID><Abstract><Abstr... | Brachyuran crabs can effectively modulate cardiac stroke volume independently of heart rate in response to abiotic drivers. Non-invasive techniques can help to improve the understanding of cardiac performance parameters of these animals. This study demonstrates the in vivo quantification of cardiac performance paramete... |
2,328,195 | Watch out for the special location of intraventricular silicone oil following an intraocular tamponade - a 10-year follow-up case report based on CT/MRI. | Intraventricular silicone oil is a relatively rare complication resulted from silicone oil tamponade to treat retinal detachment. It is occasionally reported in previous literature. To the best of our knowledge, the long-term longitudinal comparisons of silicone oil both in the brain and in the postoperative eyeball ba... |
2,328,196 | Transcriptomic Responses of Bisphenol S Predict Involvement of Immune Function in the Cardiotoxicity of Early Life-Stage Zebrafish (<i>Danio rerio</i>). | Bisphenol S (BPS), an alternative for bisphenol A (BPA) that is present in thermal paper and numerous consumer products, has been linked to estrogenic, cytotoxic, genotoxic, neurotoxic, and immunotoxic responses. However, the mechanisms of BPS toxicity remain poorly understood. Here, following exposure to environmental... |
2,328,197 | Progressively Enlarged Convexity Arachnoid Cysts in Elderly Patients: A Report of 2 Cases. | Generally, enlargement of arachnoid cysts (ACs) has been found mostly in cases occurring during early childhood. Therefore, progressively enlarged ACs found to be symptomatic in elderly patients are extremely rare, and the mechanisms have remained unexplored.</AbstractText>Our first patient was a 72-year-old woman with... |
2,328,198 | Pontocerebellar Hypoplasia Maps to Chromosome 7q11.23: An Autopsy Case Report of a Novel Genetic Variant. | Pontocerebellar hypoplasias are a group of autosomal recessive neurodevelopmetal disorders with varied phenotypic presentations and extensive genetic mutational landscape that are currently classified into ten subtypes. This classification is based predominantly on the genetic iterations as the phenotypic presentations... |
2,328,199 | Cilia-driven flows in the brain third ventricle. | The brain ventricles are interconnected, elaborate cavities that traverse the brain. They are filled with cerebrospinal fluid (CSF) that is, to a large part, produced by the choroid plexus, a secretory epithelium that reaches into the ventricles. CSF is rich in cytokines, growth factors and extracellular vesicles that ... |
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