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30,300 | Oral direct thrombin inhibition: an effective and novel approach for venous thromboembolism. | Venous thromboembolism is a serious illness that affects patient morbidity and mortality and presents a significant management challenge to healthcare providers world-wide. Despite major achievements in the significant reduction of thromboembolic complications, the most common therapies currently used for prevention an... |
30,301 | Guidelines and alternatives for neuraxial anesthesia and venous thromboembolism prophylaxis in major orthopedic surgery. | Neuraxial anesthesia during major orthopedic surgery, combined with venous thromboembolism prophylaxis, is generally safe and well tolerated, with potential benefits over general anesthesia. The risk of spinal/epidural hematoma, a rare but very serious complication, can be minimized by careful patient selection and att... |
30,302 | Outcome data for peripherally inserted central catheters used in an acute care setting. | Retrospective outcome accumulation data are presented for peripherally inserted central catheters (PICCs) placed in hospitalized patients. From 1999 through 2002, a total of 4257 PICCs with catheter dwell days involving 46,854 inpatient days were studied. Outcomes were obtained through medical record reviews. Complicat... |
30,303 | Alternatives to heparin infusion. | This article offers an overview of the pathophysiology, diagnosis, and treatment of heparin-induced thrombocytopenia (HIT). This disorder is an immune-mediated reduction of platelets with subsequently increased generation of thrombin and increased risk of arterial and venous thrombosis. Heparin-induced thrombocytopenia... |
30,304 | Antifactor Xa levels in four patients with burn injuries who received enoxaparin to prevent venous thromboembolism. | Four patients with severe burn injuries received enoxaparin 40 mg twice/day subcutaneously for the prophylaxis of venous thromboembolism (VTE). Peak antifactor Xa levels were measured 4 hours after administration of a dose, and trough antifactor Xa levels were measured 30 minutes before the next scheduled dose. Ultraso... |
30,305 | [Preliminary experimental study on treatment of portal hypertension with auxiliary partial orthotopic liver transplantation]. | To evaluate the therapeutic efficacy of auxiliary partial orthotopic liver transplantation (APOLT) on portal hypertension in liver cirrhosis with amelioration of portal vein congestion, changes in portal vein pressure and status of the graft.</AbstractText>The recipients were porcine model of biliary cirrhosis reproduc... |
30,306 | Restoration of flow following haemodialysis catheter thrombus. Analysis of rt-PA infusion in tunnelled dialysis catheters. | Urokinase and streptokinase are commonly used thrombolytic agents for obstructed central venous catheters. Although proven to be efficacious, these agents have the potential to induce fibrin breakdown and streptokinase cannot be used repeatedly because of its allergenic nature. Published evidence suggests that Urokinas... |
30,307 | A systematic review of cost-effectiveness analyses of pharmacogenomic interventions. | Cost-effectiveness analysis is a widely used tool to assess the value of healthcare interventions. Our objective was to conduct a systematic review of the literature on the cost effectiveness of pharmacogenomic interventions. We found 11 studies that met our inclusion criteria. The most commonly examined disease was de... |
30,308 | Treatment of venous thromboembolism with vitamin K antagonists: patients' health state valuations and treatment preferences. | Determining the optimal duration of vitamin K antagonist (VKA) therapy for patients with venous thromboembolism (VTE) requires a weighting of the benefits and risks of treatment. The objectives of our study were to investigate patient variability in health state valuations associated with VKA therapy and treatment pref... |
30,309 | Antiphospholipid antibodies and thrombosis: association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis. | Although antiphospholipid antibodies (aPL) are associated with thrombosis, it is not known who with aPL is at higher risk for thrombosis. It was the aim of this cross-sectional study to investigate how thrombophilic factors contribute to venous or arterial thrombosis in aPL-positive individuals. In outpatient test cent... |
30,310 | In vitro comparison of the effect of fondaparinux and enoxaparin on whole blood tissue factor-triggered thromboelastography profile. | Fondaparinux and enoxaparin are both effective and safe in preventing post-operative venous thromboembolism. However, neither of them significantly influence the conventional clotting tests. We compared the influence of clinically relevant concentrations of fondaparinux and enoxaparin on normal whole blood (WB) thrombo... |
30,311 | Elevated D-dimer level is an independent risk factor for cardiovascular death in out-patients with symptoms compatible with heart failure. | D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concernin... |
30,312 | Plasma fibrinogen concentration predicts the risk of myocardial infarction differently in various parts of Europe: effects of beta-fibrinogen genotype and environmental factors. The HIFMECH Study. | The propensity to atherothrombotic disease differs in Europe, with high-risk regions located in the North of Europe and lowrisk regions in the South of Europe. The HIFMECH study (Hypercoagulability and Impaired Fibrinolytic function MECHanisms predisposing to myocardial infarction (MI) study) was undertaken to elucidat... |
30,313 | Lack of plasminogen activator inhibitor-1 enhances the preventive effect of DX-9065a, a selective factor Xa inhibitor, on venous thrombus and acute pulmonary embolism in mice. | We have studied the physiological effects of DX-9065a, a selective factor Xa (FXa) inhibitor, and heparin in experimental venous thrombus and acute pulmonary embolism. Moreover, the effects of these compounds were also evaluated under the condition of plasminogen activator inhibitor-1 (PAI-1) deficiency. A thrombus was... |
30,314 | Normal functional protein S activity does not exclude protein S deficiency. | Protein S (PS) deficiency appears to increase the risk of venous thrombosis. PS deficiency is classified into three phenotypes using antigenic levels and functional activity. By definition, all three phenotypes of PS deficiency should result in low activated protein C cofactor activity. We compared the results of funct... |
30,315 | Low-molecular-weight heparin and cancer survival: review of the literature and pooled analysis of 1,726 patients treated for at least three months. | Heparin has been the main subject of intensive investigation and clinical use because of its therapeutic anticoagulant properties. It also exhibits many other biological activities, and it was claimed that it shows a beneficial effect on cancer spreading. Searching for papers investigating the effect of low-molecular-w... |
30,316 | Acquired and inherited thrombophilic factors and the risk for residual venous thrombosis. | Acquired and inherited thrombophilic factors increase the risk for (recurrent) venous thrombotic disease. However, little is known about the pathophysiological mechanisms causing these recurrences, or the persistence of thrombosis despite adequate treatment. Because residual thrombosis has been associated with a worse ... |
30,317 | Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative. | Limited information is available from large clinical investigations about the agreement among sources of diagnoses for endpoints. The authors used data from the Women's Health Initiative clinical trials and observational study from January 1994 to November 2000 to evaluate the agreement among self-report, hospital disc... |
30,318 | Negative D-dimer result to exclude recurrent deep venous thrombosis: a management trial. | All of the available diagnostic tests for deep venous thrombosis (DVT) have limitations for excluding acute recurrent DVT. Measurement of plasma d-dimer by using an automated quantitative assay may be useful as a rapid exclusion test in patients with suspected recurrent DVT.</AbstractText>To test the safety of withhold... |
30,319 | Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors. | A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 (JTV-803) exhibited potent inhibitory activity against FXa and good selectivity with respect to other serine proteases (thrombin, plasmin, and trypsin). In addition, compound ... |
30,320 | Staging deep venous thrombosis using ultrasound elasticity imaging: animal model. | Deep venous thrombi undergo progressive hardening with age. However, the evolution rate remains poorly characterized by both invasive and noninvasive techniques. In a previous study (Emelianov et al. 2002), we demonstrated the potential of ultrasound elasticity imaging to noninvasively detect and age thrombus using a r... |
30,321 | [Muscular haematoma in Henoch-Schönlein purpura]. | Henoch-Schonlein purpura is one of the most frequent systemic vasculitis in children. In adults, muscle involvement is extremely rare and not very well characterized. We report a case of Henoch-Schonlein purpura with severe skin and renal involvement in witch multiple intramuscular haematoma leaded to severe anaemia. H... |
30,322 | [Cerebral thrombophlebitis revealing hyperthyroidism: two cases report and literature review]. | Two cases of hyperthyroidism revealed by a cerebral venous thrombosis are reported.</AbstractText>Clinical symptomatology consisted of intra-cranial hypertension and convulsive crisis associated to thyrotoxicosis. Evolution was favorable with etiologic and symptomatic therapy.</AbstractText>The cerebral venous thrombos... |
30,323 | [Venous tromboembolic treatment in patients with cancer]. | Venous tromboembolic treatment in patients with cancer can be a clinical dilemma. Comorbid conditions, significant risk of recurrence of bleeding associated with warfarin, difficult venous access, are some of the factors that often complicate anticoagulants therapy in patients with cancer.</AbstractText>Low molecular w... |
30,324 | [Retinal vascular occlusions: diagnosis and management]. | The diagnosis of retinal venous and arterial occlusions is usually easily evoked on visual symptoms and ophthalmoscopic features. However, their management (etiologic explorations and treatment) has not been formally established and remains controversial.</AbstractText>Some retinal vascular occlusions may result of loc... |
30,325 | [Recombinant activated factor VII as a life-saving therapy for severe postpartum haemorrhage unresponsive to conservative traditional management]. | Postpartum haemorrhage remains the main cause of maternal morbidity and mortality. Treatment aims at maintaining hemodynamic circulation and preventing shock by stopping blood loss both medically and surgically. We report two cases of major postpartum haemorrhage due to uterine atony. Patients developed haemorrhagic sh... |
30,326 | The laparoscopic repair of suprapubic ventral hernias. | The complexity of dissection and the close proximity of the hernia to bony, vascular, nerve, and urinary structures make the laparoscopic repair of suprapubic hernias (LRSPH) a formidable operation. We performed a prospective evaluation of the outcomes of patients undergoing LRSPH.</AbstractText>The study population co... |
30,327 | Heparin-induced thrombocytopenia after coronary artery bypass grafting with cardiopulmonary bypass: report of a case. | A 79-year-old man was transferred to our hospital with severe chest pain and a suspected diagnosis of acute myocardial infarction. Emergency cardiac catheterization showed triple-vessel coronary artery disease, and we performed coronary artery bypass grafting under cardiopulmonary bypass (CPB). Continuous hemodiafiltra... |
30,328 | Clinically evident venous thromboembolic events in children with brain tumors. | We evaluated the incidence and significance of central venous access device dysfunction and symptomatic major thrombosis in 253 pediatric patients with brain tumors. Central venous access device dysfunction was a common complication (28.4%) and was associated with major thrombosis development and a reduced overall surv... |
30,329 | Exchange reamed nailing for aseptic nonunion of the tibia. | Exchange reamed nailing of the tibia is a common procedure in the treatment of an aseptic tibial nonunion. However, reports in the literature supporting this technique are limited.</AbstractText>Forty patients with a tibial nonunion after initial unreamed intramedullary nailing were retrospectively assessed after an ex... |
30,330 | Relevance of the Agency for Healthcare Research and Quality Patient Safety Indicators for children's hospitals. | Patient safety indicators (PSIs) were developed by the Agency for Healthcare Research and Quality. Our objectives were (1) to apply these algorithms to the National Association of Children's Hospitals and Related Institutions (NACHRI) Aggregate Case Mix Comparative Database for 1999-2002, (2) to establish mean rates fo... |
30,331 | Deep vein thrombosis after total hip and knee arthroplasty in Indian patients. | Deep vein thrombosis (DVT) is one of the most common complications of total hip (THA) and total knee arthroplasty (TKA). Though the reported incidence of DVT is very high, that of proximal DVT is low and that of fatal thromboembolism is very low. Hence the issue of prophylaxis for DVT remains controversial. The inciden... |
30,332 | Deep venous thrombosis revealed during ultrasound-guided femoral nerve block. | Ultrasound imaging used to facilitate performance of a femoral nerve block also affords imaging of adjacent anatomical structures. Following a fracture of the femur, an ultrasound guided femoral nerve block (UGFNB) was performed to provide analgesia; this led to the incidental finding of a previously undiagnosed femora... |
30,333 | Androgen-induced cerebral venous sinus thrombosis in a young body builder: case report. | Cerebral venous sinus thrombosis is an infrequent disease with a variety of causes. Pregnancy, puerperium, contraceptive pills and intracranial infections are the most common causes. The patient may present with headache, focal neurological deficits and seizures.The clinical outcome is highly variable and treatment wit... |
30,334 | Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation. | Warfarin is a widely used anticoagulant with efficacy in treatment and prevention of thrombosis. Patient management, however, is difficult because of interindividual variation in response to standard doses due to significant differences in metabolic rates. Warfarin metabolism is under genetic control, involving primari... |
30,335 | Venous congestive myelopathy: a mimic of neoplasia. | Venous congestive myelopathy is a progressive disorder frequently associated with arteriovenous fistulas, usually dural. By causing diffuse spinal cord enlargement and enhancement on imaging, it may simulate a neoplasm and prompt a biopsy. We evaluated the biopsy findings in seven such patients (M=5, F=2, mean age 59+/... |
30,336 | Neck mass due to thrombosis of the jugular vein in patients with cancer. | The hypothesis that jugular thrombosis (JT) may cause a mass in the cervical region is usually overlooked. The objective of the present study was to identify the characteristics of neck masses resulting from JT in cancer patients and to analyze the possible reasons for their formation. A retrospective study was conduct... |
30,337 | [Safety profile of raloxifene]. | Selective estrogen receptor modulators (SERMs) are a diverse group of non-steroidal (non hormonal) compounds developed to offer the postmenopausal women many of the advantages of estrogen therapy (ET) while avoiding undesired effects on reproductive and other tissues. Tamoxifen and toremifene, first generation SERMs ar... |
30,338 | [Effects of SERM on breast cancer and cardiovascular disease: making a comparison between raloxifene use and hormone replacement therapy on the risks of the diseases]. | According to the report of MORE trial, raloxifene (RLX) compensate for the faults of hormone replacement therapy with the reasons following below; 1) RLX inhibits onset of breast cancer with estrogen receptor remarkably, 2) RLX inhibits onset of cardiovascular disease in its high risk group. However, because RLX has a ... |
30,339 | Hyperhomocysteinaemia is associated with uveitis but not with deep venous thrombosis in Behcet's disease. | Plasma homocysteine was assessed in Behcet's disease (BD) patients in order to determine the prevalence of hyperhomocysteinaemia in BD and to test its association with clinical manifestations of the disease. The study included 59 patients with BD and 118 age- and sex-matched healthy subjects. Plasma homocysteine, vitam... |
30,340 | Diminished response to activated protein C is not correlated with severity of peripheral arterial occlusive disease. | Poor response to activated Protein C (APC) is a well established risk factor for venous thromboembolism. More recently, the hypercoagulable state which results from diminished response to APC has also been associated with arterial thrombosis. Some studies showed a clear association between low response to APC with adva... |
30,341 | Revisiting antiphospholipid antibodies: from targeting phospholipids to phospholipid binding proteins. | The antiphospholipid syndrome (APS) is a multi-system prothrombotic disorder associated with circulating auto-antibodies directed against various phospholipid-binding proteins. The major clinical manifestations are recurrent arterial or venous thrombosis, but due to its heterogeneity, atypical presentations can obscure... |
30,342 | Variable pump flow-based Doppler ultrasound method: a novel approach to the measurement of access flow in hemodialysis patients. | Decreasing vascular access flow (Qa) is an important predictor of future access thrombosis and malfunction for hemodialysis (HD) patients. Among all of the methods for determining Qa, the variable pump flow (VPF) Doppler method measures Qa according to the change in Doppler signal between the arterial and the venous ne... |
30,343 | Incidence and risk factors of early venous thrombosis associated with permanent pacemaker leads. | Pacemaker lead implantation can cause thrombosis, which can be associated with serious local morbidity and complicated by pulmonary embolism. Few reliable estimates of the incidence of thrombosis have been reported. The contribution of established risk factors to venous thrombosis in patients with implanted pacemaker l... |
30,344 | Evidence-based risk factors for postoperative deep vein thrombosis. | Deep vein thrombosis (DVT) is a common postoperative complication that is associated with significant morbidity and mortality. Thromboprophylaxis has been shown to be underused. In the absence of prophylaxis, rates as high as 50% have been reported following orthopaedic surgery, and 25% following general surgery. Many ... |
30,345 | Safety and efficacy of the POP technique for restoring patency to occluded PIC catheters. | Peripheral-inserted central catheters (PICCs) offer a successful alternative to peripheral venipuncture for long term medication therapy. When catheters become occluded, the nurse must intervene to avoid delayed or missed treatments. Pharmacological interventions are costly and not without risks. The purpose of this ex... |
30,346 | [Moya-moya syndrome and arterial dysplasia associated to Down syndrome]. | Ischemic vascular pathologies are predominant among the neurological processes associated to Down syndrome. Thrombosis of the venous sinuses, Moya-moya syndrome and arterial dysplasia, among others, stand out for their association with this syndrome.</AbstractText>We describe the case of a 19-year-old female patient su... |
30,347 | Modes and consequences of thrombin's interaction with fibrin. | Thrombin mediates the balance between coagulant and fibrinolytic forces and has numerous cellular effects. This intricate balance is maintained by biochemical mechanisms that regulate thrombin activity. Disruption of this balance could lead to bleeding or thrombosis. Once thrombin is generated, two major mechanisms reg... |
30,348 | FXIII polymorphisms, fibrin clot structure and thrombotic risk. | Fibrin clot structure is highly dependent on factor XIII activity. Activated FXIII catalyzes the formation of the peptide bonds between the gamma and alpha chains in noncovalently bound fibrin polymers and incorporates various adhesive and antifibrinolytic proteins into the final fibrin clot. In the absence of activate... |
30,349 | Portal vein thrombosis during antineoplastic chemotherapy in children: report of five cases and review of the literature. | We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ult... |
30,350 | Pulmonary venous thrombosis and infarction complicating pulmonary venous stenosis following radiofrequency ablation. | Pulmonary vein stenosis is a recently described complication of radiofrequency ablation. We report a patient who experienced thrombosis of the lingular vein and pulmonary infarction resulting from mild single-vessel pulmonary vein stenosis. This report extends available experience with complications of radiofrequency a... |
30,351 | Aneurysm of the inferior vena cava. | Aneurysms of the inferior vena cava (IVC) are extremely rare, with a range of reported presentations including deep venous thrombosis. Computerised Tomography (CT) and Magnetic Resonance Imaging (MRI) scans are suggested appropriate diagnostic imaging modalities, but even then it may not be possible to differentiate be... |
30,352 | Thrombosis of aggressive dural arteriovenous fistula after incomplete embolization. | We report the cases of three patients diagnosed with dural arteriovenous fistula (DAVF) and cortical venous reflux (CVR). All were treated by transarterial endovascular embolization. Residual shunting and cortical venous drainage continued to be present at the end of the treatment procedure, despite the fact that durin... |
30,353 | Specific oral contraceptive use and venous thromboembolism resulting in hospital admission. | To determine whether there is an increased risk of venous thromboembolism (VTE) with anti-androgen oral contraceptives containing cyproterone acetate and ethinyloestradiol.</AbstractText>Comparison of the frequency of specific oral contraceptive use in patients aged 15 to 55 years discharged from hospital with radiolog... |
30,354 | Heterozygous prothrombin 20210G/A mutation, associated with hyperhomocysteinemia, and homozygous methylenetetrahydrofolate reductase 677C/T mutation, in a patient with portal and mesenteric venous thrombosis. | We herein report a 34-year-old man who was investigated for severe abdominal pain. Portal vein thrombosis (PVT) and mesenteric vein thrombosis (MVT) were diagnosed. An association with two predisposing factors for thrombosis was noted: (1) heterozygous factor II 20210G/A mutation and (2) homozygous methylenetetrahydrof... |
30,355 | Surgical thrombectomy followed by intraoperative endovascular reconstruction for symptomatic ilio-femoral venous thrombosis. | To evaluate the efficacy of surgical thrombectomy combined with endovascular reconstruction for acute ilio-femoral/caval venous thrombosis.</AbstractText>Twenty consecutive patients with acute, symptomatic ilio-femoral/-caval thrombosis underwent valve-preserving thrombectomy with immediate endovascular repair between ... |
30,356 | Clinical significance of superficial vein thrombosis. | To evaluate the clinical implications of superficial thrombophlebitis (STP) including its demographic characteristics, distribution, risk factors, relationship with deep vein thrombosis (DVT), pulmonary embolism (PE), diagnosis and management.</AbstractText>Data were collected from relevant papers using a MEDLINE searc... |
30,357 | Safety and feasibility of recombinant factor VIIa for acute intracerebral hemorrhage. | Hematoma growth occurs in 38% of intracerebral hemorrhage (ICH) patients scanned by computed tomography (CT) within 3 hours of onset. Activated recombinant factor VII (rFVIIa) promotes hemostasis at sites of vascular injury and may minimize hematoma growth after ICH.</AbstractText>In this randomized, double-blind, plac... |
30,358 | Statins and blood coagulation. | The 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors (statins) have been shown to exhibit several vascular protective effects, including antithrombotic properties, that are not related to changes in lipid profile. There is growing evidence that treatment with statins can lead to a significant down... |
30,359 | Preventing venous thromboembolism in acute medical patients. | While extensive data support the clinical benefit and cost-effectiveness of routine thromboprophylaxis in surgical patients, the use of this approach in medical patients has been controversial. However, recent data, mainly from the MEDENOX trial, support routine thromboprophylaxis in acutely ill medical patients.</Abst... |
30,360 | Rheolytic catheter thrombectomy, balloon angioplasty, and direct recombinant tissue plasminogen activator thrombolysis of dural sinus thrombosis with preexisting hemorrhagic infarctions. | We describe the case of a 28-year-old obtunded woman who presented with bilateral anterior parietal lobe cortical hemorrhages associated with thrombosis of the superior sagittal sinus, both transverse and sigmoid sinuses, and multiple cortical veins draining into the sagittal sinus. Initial heparin therapy was not effe... |
30,361 | Isolated cortical venous thrombosis presenting as subarachnoid hemorrhage: a report of three cases. | Cortical venous thrombosis (CVT) without concomitant dural sinus thrombosis is an uncommon disorder. Isolated CVT usually manifests on imaging studies as focal parenchymal hemorrhage or edema. We report three cases of isolated CVT that presented with unilateral, localized subarachnoid hemorrhage without parenchymal inv... |
30,362 | Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging. | The common entity cerebral venous sinus thrombosis is associated with the poorly characterized imaging finding of parenchymal abnormalities; diffusion-weighted imaging has offered some insight into these manifestations. We assessed the relationship between the diffusion constant from apparent diffusion coefficient (ADC... |
30,363 | Mondor's disease of breast. | A case of Mondor's disease of breast in a 32 years old lady is described. She presented with painful vertical subcutaneous cords under her left breast. On scintimammography a suspicious nodule in her breast was detected, which revealed to be benign epithelial lesion on FNAC. With reassurance and placebo, the disease re... |
30,364 | Two mechanical devices for prophylaxis of thromboembolism after total knee arthroplasty. A prospective, randomised study. | The optimal characteristics of pneumatic compression for mechanical prophylaxis of thromboembolism after total knee arthroplasty (TKA) are not known. Our study compared two methods of calf compression, with the hypothesis that the device which provided a larger increase in peak venous velocity would produce a lower rat... |
30,365 | [Anticoagulant treatment in hemorrhagic brains infarts due to large sinus venous thrombosis]. | Cerebral venous and sinus thrombosis is an infrequent condition which presents with a wide spectrum of signs and a variable mode of onset. Sinus thrombosis may cause isolated intracranial hypertension but also may cause cerebral venous infarcts, which are frequently hemorrhagic. Treatment with antithrombotic agents is ... |
30,366 | The role of shear stress in the pathogenesis of atherosclerosis. | Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag force acting on the vessel wall is mechanotransduced into a biochemical signal that results in changes in vascular behavior. Maintenance... |
30,367 | Management of severe Budd-Chiari syndrome: report of 147 cases. | Budd-Chiari syndrome (BCS) is an uncommon disorder caused by the obstruction of hepatic venous outflow and/or the inferior vena cava. Major therapeutic approaches include operation and radiological intervention. This study was conducted to investigate the treatment of severe BCS.</AbstractText>The clinical data of 147 ... |
30,368 | Symptomatic venous thromboembolism in acute leukemia. Incidence, risk factors, and impact on prognosis. | The association between malignant disorders and occurrence of venous thromboembolism is well established. Patients with cancer and venous thromboembolism have adverse prognosis. No systematic study on the incidence and prognostic impact of venous thromboembolism in acute leukemia has been performed as yet. We retrospec... |
30,369 | Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis. | Plasma levels of granulocyte-derived elastase (GE-XDP), D-dimer and soluble fibrin (SF) were examined in 53 patients with deep vein thrombosis (DVT) and in 100 healthy volunteers. The mean plasma level of D-dimer was 0.92+/-0.81 microg/ml (+/-S.D.) in healthy volunteers and the mean+2 S.D. value (cutoff value for DVT) ... |
30,370 | Late saphenous vein graft occlusion in patients with coronary bypass: possible role of aspirin resistance. | Late venous graft thrombosis, leading to recurrent ischemia, is frequently encountered in old, degenerated vein grafts with advanced atherosclerotic plaque formation. Aspirin has been indicated to maintain venous graft patency in the post-operative period. However, there is considerable evidence that aspirin resistance... |
30,371 | Evidence based treatment of the antiphospholipid syndrome II. Optimal anticoagulant therapy for thrombosis. | Current consensus recommendations suggest that patients with antiphospholipid antibodies (APLA) are at high risk of recurrent arterial or venous thromboembolism (VTE) despite warfarin administered to achieve an international normalized ratio (INR) of 2.0 to 3.0. These recommendations have been called into question by t... |
30,372 | Venous thromboembolism and escitalopram. | Selective serotonin reuptake inhibitors (SSRIs) are currently used as a first-line treatment for depression, as they have a favorable side-effect profile. Escitalopram, a new SSRI, is also well-tolerated and serious side effects are rarely associated with its use. There have been several reports that SSRIs might increa... |
30,373 | The efficacy of a single daily dose of enoxaparin for deep vein thrombosis prophylaxis following total knee arthroplasty. | Deep vein thrombosis (DVT) is a major risk following total knee arthroplasty (TKA). This prospective outcomes study evaluates the efficacy of enoxaparin 40 mg once daily for 7 days after TKA, by documenting symptomatic and asymptomatic outcomes using bilateral lower extremity duplex ultrasound upon hospital discharge a... |
30,374 | Haemostatic alterations in colorectal cancer: perspectives for future treatment. | The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumo... |
30,375 | Transient severe eosinophilia precipitating massive venous thrombosis in a patient with hereditary thrombophilia. | We describe a patient homozygous for both the prothrombin G20210A and methylenetetrahydrofolate reductase C667T mutations who was symptom-free for 40 years and developed near-catastrophic thrombotic complications following transient, severe eosinophilia. This course of events raises the possibility of an increased risk... |
30,376 | Deep vein thrombosis and malignancy: a surgical oncologist's perspective. | Oncology patients are at increased risk of developing deep vein thrombosis (DVT) and its potentially fatal sequel, pulmonary embolism. This is due to multiple factors, including the presence of the malignancy itself, comorbid factors and therapy-related interventions. Issues that are peculiar to venous thrombosis in th... |
30,377 | Essential fatty acid status in infants and children with chronic liver disease. | The relationship between essential fatty acid (EFA) status and degree of hyperbilirubinaemia and oxidant stress in infants and children with chronic liver diseases was evaluated. Thirty patients with chronic cholestasis and 30 with liver cirrhosis were examined; 30 healthy subjects served as controls. Patient groups ha... |
30,378 | Errors in laparoscopic surgery. | Laparoscopic surgery is the most significant advancement in the field of surgery over the past 15 years. This minimal access approach has been widely embraced and adopted to many common operations. Demonstrated benefits include decreased post-operative pain, shorter lengths of in-patient hospitalization, increased pati... |
30,379 | The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement.<Pagination><StartPage>1679</StartPage><EndPage>1683</EndPage><MedlinePgn>1679-1683</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1213/01.ANE.0000136770.75805.19</ELocationID><Abstract><... | To assess the blood-sparing efficacy of tranexamic acid (TA) administered orally or via a variable IV infusion, 80 healthy patients undergoing elective total knee replacement were studied according to a prospective, controlled, randomized, single-blinded study design. Patients were allocated to one of four treatment gr... |
30,380 | Pathogenesis and pathology of delayed xenograft rejection in pig-to-rhesus monkey cardiac transplantation. | It has been recognized that delayed xenograft rejection (DXR) is the major barrier to the acceptance of xenotransplantation after overcoming hyperacute rejection.</AbstractText>This study sought to investigate the pathogenesis and pathology of delayed xenograft rejection following pig-to-rhesus monkey heart xenotranspl... |
30,381 | Portal vein arterialization for liver transplantation with extensive portomesenteric vein thrombosis: a case report. | We report herein a case of extensive thrombosis of portal venous system including mesenteric vein in a 70-year-old man who suffered from end-stage post-hepatitis C cirrhosis and who underwent orthotopic liver transplantation. There was no way to divert portal blood flow to the new liver because such an extensive thromb... |
30,382 | Temporary vascular catheters for hemodialysis: a 3-year prospective study. | Temporary hemodialysis catheters are necessary in patients with uremia, but complications associated with these catheters represent one of the most important sources of morbidity among ESRD patients. There is no general agreement about the optimal venous access for insertion of a central venous catheter, while risk fac... |
30,383 | [Surgery in acute pulmonary embolism can be a life-saving therapeutic alternative. A follow up of surgically treated patients]. | Acute pulmonary embolism occurs in about 10,000 people annually in Sweden, in more than 1000 of whom it has a fatal outcome. The clinical presentation may vary considerably, and a large number of patients with pulmonary embolism are still misdiagnosed. Most patients are treated with anticoagulants and some also with th... |
30,384 | Hip fracture and venous thromboembolism in the elderly. | Venous thromboembolism (VTE), a highly prevalent vascular disorder, is frequently clinically silent, and is often difficult to diagnose. VTE consists of both deep vein thrombosis (DVT) and pulmonary embolism (PE), both of which are associated with potentially significant morbidity and mortality. With the availability o... |
30,385 | [Effectiveness of treatment of varicose veins assessed by epidemiological comparative studies]. | Effectiveness of varicose veins (VV) management, due to high prevalence of this condition, is an important medical, social and economical issue. The aim of the study was to compare cost effectiveness of VV treatment by comparison of the results of two epidemiological surveys performed in Warsaw Bródno population, ... |
30,386 | [Echo Doppler post total hip arthroplasty: retrospective: study of 111 patients at CHBAH]. | We studied all the patients who underwent a total hip arthroplasty during the last six months of 2001. They all had a postoperative venous Doppler echo (possibly repeated) followed by a phlebography in case of clinical doubt. They all received a prophylactic treatment by low molecular weight heparin. Our rate of deep v... |
30,387 | Non-accidental fatal head injury in small children--a clinico-pathological correlation. | Non-accidental head injury leading to massive intracranial trauma has been identified as a leading cause of death in small children. In a typical case, a child usually below the age of one year is violently shaken, leading to rupture of the connecting veins between the dura mater and the brain substance with variable d... |
30,388 | Innovative therapies: intraoperative intracavitary chemotherapy. | Both phase I studies demonstrated that high-dose cisplatin can be delivered safely with acceptable complication rates. The maximum tolerated doses of 225 mg/m2 and 250 mg/m2 cisplatin, respectively, are higher than any other published report of intrapleural cisplatin. The intrapleural cisplatin doses reported in other ... |
30,389 | Use of suture-mediated vascular closure devices for the management of femoral vein access after transcatheter procedures. | Groin complications remain the most common complication of cardiac catheterization procedures. While the use of closure devices is increasing for arterial sheaths, venous sheaths tend to be removed and hemostasis achieved with manual compression. We report our experience using Perclose suture-mediated vascular closure ... |
30,390 | Load-shifting brace treatment for osteoarthritis of the knee: a minimum 2 1/2-year follow-up study. | Objectives in treating primarily unicompartmental knee arthritis with a load-shifting brace are pain relief, compliance, brace durability, and complication-free treatment over multiple years. This was a single institution retrospective chart review, radiograph review, and telephone survey of patients treated from 1997 ... |
30,391 | Unruptured dural arteriovenous malformation of the transverse-sigmoid sinus presenting with focal symptoms and coma. | We are presenting the case of a 63 year-old man with a dural arteriovenous malformation of the transverse sigmoid sinus who developed focal deficits followed by less localized symptoms such a disorientation, lethargy and eventually comatose status. Initial cerebral angiography showed retrograde filling of the cortical ... |
30,392 | [Valvular transposition in patients with ulcers of the lower limbs following post thrombotic syndromes]. | Venous ulcers in patients with post thrombotic syndromes are complex situations with multiple therapeutic options. They are responsible for high morbidity rates, conservative treatment is very slow and recurrences are very common. Deep venous reconstructive surgery is an alternative, but it should be based on the morph... |
30,393 | Cerebral venous sinus thrombosis in a neonate with homozygous prothrombin G20210A genotype. | We describe a 7-day-old infant who presented with extensive cerebral venous sinus thrombosis (CVST) and was found to be homozygous for the prothrombin G20210A gene mutation. No other known risk factors for thrombosis were identified. |
30,394 | Clinical and economic outcomes in thrombolytic treatment of peripheral arterial occlusive disease and deep venous thrombosis. | Over the past 2 decades the use of thrombolytic therapy in the management of peripheral occlusive diseases, most notably peripheral arterial occlusion (PAO) and deep venous thrombosis (DVT), has become an accepted and potentially preferable alternative to surgery. We examined the period when urokinase was in short supp... |
30,395 | Pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis: safety and feasibility study. | The current standard of care for deep venous thromboembolism (DVT) is anticoagulation; however, this treatment method does not rapidly relieve clot burden or clinical symptoms. We describe a rapid and effective method of thrombus removal, with simultaneous percutaneous mechanical thrombectomy (PMT) and thrombolysis.</A... |
30,396 | Role of prophylactic temporary inferior vena cava filters placed at the ICU bedside under intravascular ultrasound guidance in patients with multiple trauma. | Patients with multiple trauma often have injuries that preclude the use of anticoagulation therapy or sequential compression device prophylaxis. Temporary inferior vena cava (IVC) filters (IVCFs) offer protection against pulmonary embolism during the early immediate injury and perioperative period, when risk is highest... |
30,397 | Early experience with retrievable inferior vena cava filters in high-risk trauma patients.<Pagination><StartPage>869</StartPage><EndPage>874</EndPage><MedlinePgn>869-74</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">This study describes the use of retrievable IVC filters in... | This study describes the use of retrievable IVC filters in a select group of trauma patients at high risk for deep vein thrombosis (DVT) and pulmonary embolism (PE).</AbstractText>Retrievable IVC filters were placed in selected trauma patients who met high-risk criteria for deep vein thrombosis and PE according to inst... |
30,398 | Clinical and experimental experience with factor Xa inhibitors. | Cardiovascular disease is the major cause of mortality in the industrial world today. We are constantly moving towards new and better ways of fighting this epidemic. Advances have been made in various fields such as patient education, imaging techniques, interventional cardiology, and novel therapeutic agents. In parti... |
30,399 | Computed tomographic findings in Lemierre syndrome. | Lemierre syndrome, also known as postanginal septicemia, has long been taken as an uncommon condition with life-threatening potential. It, resulting from acute oropharyngeal infection, could lead to septic thrombophlebitis of the internal jugular vein (IJV). Substantial decrease of mortality and morbidity with the intr... |
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