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Schedule 1.94: Corporate Names |
The Scripps Research Institute |
Scripps Research |
Calibr, a division of Scripps Research |
Calibr |
TSRI |
Schedule 1.119: Existing Patents |
[See attached.] |
Matters 70 items |
Client-Matter Cooley Docket Title Country Application Num Application Date Publication Num Publication Date Registration Num Registration Date Case Status Inventors Applicant TSRI Ref |
SWITCHABLE CAR-T THERAPIES FOR TREATING HUMAN CANCERS World Intellectual Property Organization PCT US22/081010 12/6/2022 WO 2023 107910 6/15/2023 Published Travis YOUNG, Eduardo LABORDA 2120.1PC |
SWITCHABLE CAR-T THERAPIES FOR TREATING HUMAN CANCERS United States 63/286,868 12/7/2021 Expired Travis YOUNG, Eduardo LABORDA 2120.0P |
NOVEL THERAPIES WITH ENGINEERED EFFECTOR CELLS World Intellectual Property Organization PCT US22/023791 7/2022 WO 2022 216906 10/13/2022 Published Travis YOUNG, Nelson Bruno 2081.1PC |
NOVEL CANCER THERAPIES WITH SWITCHABLE CAR-T PLATFORMS United States 63/172,212 8/2021 Abandoned Travis YOUNG, Nelson Bruno 2081.0P |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... United States 16/343,353 4/18/2019 20190359697 11/28/2019 11,174,306 11/16/2021 Issued Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1US |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... World Intellectual Property Organization PCT US17/057460 10/19/2017 WO 2018/075807 4/26/2018 Expired Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1PC |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Republic of Korea 10-2019-0065433 5/17/2019 20200138985 12/11/2020 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1KR |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Japan 2022-153946 9/27/2022 2022-185016 12/13/2022 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1JPD1 |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Japan 2019-520888 10/19/2017 2019-535241 12/12/2019 7149935 9/29/2022 Issued Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1JP |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Hong Kong 62020002300.5 10/19/2017 HK1291004 7/31/2020 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1HK |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... European Patent Office 17794509.4 5/14/2019 3529268 8/28/2019 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1EP |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... China 201780076966.5 6/12/2019 110267982 9/20/2019 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1CN |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Canada 3,040,343 10/19/2017 3040343 4/26/2018 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1CA |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... United States 17/461,365 8/30/2021 20220073597 3/10/2022 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1C1 |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... Australia 2017345479 10/19/2017 2017345479 5/9/2019 Published Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.1AU |
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANI... United States 62/410,315 10/19/2016 Expired Travis YOUNG, Leonard PRESTA, David RODGERS, Eric HAMPTON, Ti... 1924.0P |
OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES... United States 15/566,680 10/13/2017 20190169289 6/6/2019 11,091,546 8/17/2021 Issued Travis YOUNG, David RODGERS, Ian Hardy, Chanhyuk KIM, Peter G. S... 1923.2US |
OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES... World Intellectual Property Organization PCT US2016/027997 4/15/2016 WO 16/168773 10/20/2016 Expired Eric HAMPTON, Travis YOUNG, David RODGERS, Ian Hardy, Peter G... 1923.2PC |
OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES... Hong Kong 18110231.8 8/19/2018 HK1250661 1/11/2019 Published Eric HAMPTON, Travis YOUNG, David RODGERS, Ian Hardy, Chanhyu... 1923.2HK |
OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES... European Patent Office 16780958.1 4/15/2016 3283113 2/21/2018 Published Travis YOUNG, David RODGERS, Ian Hardy, Chanhyuk KIM, Peter G. S... 1923.2EP |
CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF United States 62/253,467 11/10/2015 Expired Travis YOUNG, David RODGERS, Ian Hardy, Chanhyuk KIM, Peter G. S... 1923.1P |
OPTIMIZED CHIMERIC RECEPTOR CELL SWITCHES AND USES THEREOF United States 62/148,063 4/15/2015 Expired Travis YOUNG, David RODGERS, Ian Hardy, Chanhyuk KIM, Peter G. S... 1923.0P |
CHIMERIC RECEPTOR T CELLS AND USES THEREOF United States 15/561,274 9/25/2017 20180118808 5/3/2018 10,800,828 10/13/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1922.1US |
SWITCHABLE NON-scFv CHIMERIC RECEPTOR T CELLS AND USES THEREOF World Intellectual Property Organization PCT US2016/024252 3/28/2016 WO 16/154621 9/29/2016 Expired Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1922.1PC |
CHIMERIC RECEPTOR T CELLS AND USES THEREOF United States 62/138,901 3/26/2015 Expired Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1922.0P |
OPTIMIZED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF United States 15/566,685 4/15/2016 Abandoned Chanhyuk KIM, Travis YOUNG, Jennifer MA, Ji Young KIM, Hui WANG... 1771.3US |
OPTIMIZED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF World Intellectual Property Organization PCT US2016/027990 4/15/2016 WO 16/168766 10/20/2016 Expired Chanhyuk KIM, Travis YOUNG, Jennifer MA, Ji Young KIM, Hui WANG... 1771.3PC |
CHIMERIC RECEPTOR T CELL SWITCHES FOR HER2 World Intellectual Property Organization PCT US2016/027993 4/15/2016 WO 16/168769 10/20/2016 Expired Yu J. CAO, Travis YOUNG, Peter G. SCHULTZ 1771.2PC |
CHIMERIC RECEPTOR T CELL SWITCHES FOR HER2 United States 62/253,465 11/10/2015 Expired Yu J. CAO, Travis YOUNG, Peter G. SCHULTZ 1771.1P |
CHIMERIC RECEPTOR T CELL SWITCHES FOR HER2 United States 62/148,070 4/15/2015 Expired Yu J. CAO, Travis YOUNG, Peter G. SCHULTZ 1771.0P |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United States 18/056,554 11/17/2022 Pending Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.6C |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United States 17/713,489 5/2022 Abandoned Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.6C3 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United States 16/532,860 8/6/2019 20200197497 6/25/2020 Abandoned Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.6C2 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United States 15/484,477 4/2/2017 20170246270 8/31/2017 10,391,155 8/27/2019 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.6C1 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United States 14/688,899 4/16/2015 20150307564 10/29/2015 9,624,276 4/18/2017 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.6 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... World Intellectual Property Organization PCT US14/060684 10/15/2014 WO 15/057834 4/23/2015 Expired Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5PC |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Republic of Korea 10-2016-7012414 10/15/2014 20160062760 6/2/2016 10-2339240 12/9/2021 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5KR |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Japan 2020-037808 3/5/2020 20200196604 6/25/2020 Abandoned Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5JPD1 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Japan 2016-522782 10/15/2014 2016533174 10/27/2016 6734477 7/14/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5JP |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Italy 14854285.5 10/15/2014 502020000012146 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5IT |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Hong Kong 17100359.6 7/17/2023 1226751A 10/6/2017 Published Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5HK |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... United Kingdom 14854285.5 10/15/2014 3057990 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5GB |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... France 14854285.5 10/15/2014 3057990 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5FR |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Spain 14854285.5 10/15/2014 3057990 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5ES |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... European Patent Office 14854285.5 10/15/2014 3057990 8/24/2016 3057990 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5EP |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Germany 14854285.5 10/15/2014 602014070576.6 9/23/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5DE |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... China 201480066872.6 10/15/2014 105829349 8/3/2016 ZL 201480066872.6 2/3/2023 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5CN |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Canada 2,927,543 10/15/2014 2927543 4/23/2015 2,927,543 7/20/2021 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5CA |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Australia 2020207804 10/15/2014 2020207804 8/6/2020 Abandoned Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5AUD1 |
PEPTIDIC CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THE... Australia 2014337367 10/15/2014 2014337367 4/7/2016 2014337367 8/13/2020 Issued Travis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ 1666.5AU |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF United States 14/432,065 3/27/2015 2015-0238631 8/27/2015 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4US |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF World Intellectual Property Organization PCT US14/060713 10/15/2014 WO 15/057852 4/23/2015 Expired Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4PC |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Republic of Korea 10-2016-7012417 10/15/2014 20160062761 6/2/2016 10-2357968 1/26/2022 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4KR |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Japan 2019-186117 10/9/2019 2020015760 1/30/2020 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4JPD1 |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Japan 2016-522791 10/15/2014 2016534995 11/10/2016 6637415 12/27/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4JP |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Italy 14853242.7 10/15/2014 502019000006215 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4IT |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Hong Kong 17100358.7 10/15/2014 HK1226750A 10/6/2017 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4HK |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF United Kingdom 14853242.7 10/15/2014 3057991 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4GB |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF France 14853242.7 10/15/2014 3057991 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4FR |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Spain 14853242.7 10/15/2014 3057991 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4ES |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF European Patent Office 14853242.7 10/15/2014 3057991 8/24/2016 3057991 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4EP |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Germany 14853242.7 10/15/2014 602014046575.7 5/8/2019 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4DE |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF China 201480064779.1 10/15/2014 105814083 7/27/2016 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4CN |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Canada 2,926,698 10/15/2014 2,926,698 4/23/2015 2,926,698 6/22/2021 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4CA |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF United States 15/644,657 7/7/2017 201801044535 4/19/2018 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4C2 |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF United States 15/363,350 11/29/2016 201801044535 Abandoned Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4C1 |
CHIMERIC ANTIGEN RECEPTOR T CELL SWITCHES AND USES THEREOF Australia 2014337385 10/15/2014 2014337385 4/7/2016 2014337385 8/13/2020 Issued Chanhyuk KIM, Travis YOUNG, Yu J. CAO, Jennifer MA, Minsoo KIM, St... 1666.4AU |
CHIMERIC ANTIGEN RECEPTOR T CELLS AND USES THEREOF United States 62/009,056 6/6/2014 Abandoned Yu J. CAO, Chanhyuk KIM, Peter G. SCHULTZ, Travis YOUNG, Jennifer... 1666.2P |
METHODS OF PRODUCING SWITCHABLE CHIMERIC ANTIGEN RECEPTOR T C... United States 61/895,704 10/25/2013 Abandoned Yu J. CAO, Chanhyuk KIM, Peter G. SCHULTZ, Travis YOUNG 1666.1P |
METHODS OF PRODUCING SWITCHABLE CHIMERIC ANTIGEN RECEPTOR T C... United States 61/891,347 10/15/2013 Abandoned Yu J. CAO, Chanhyuk KIM, Peter G. SCHULTZ, Travis YOUNG 1666.0P |
Schedule 1.121: Existing Targets |
• BCMA means B-cell Maturation Antigen. Entrez Gene ID:608. HGNC ID: HGNC:11913 |
• PSMA means Prostate Specific Membrane Antigen. Entrez Gene ID:2346. HGNC ID: HGNC:3788 |
• Her 2 means Human epidermal growth factor receptor 2. Entrez Gene ID:2064. HGNC ID: HGNC:3430 |
• CD20 means Cluster of Differentiation 20. Entrez Gene ID: 931. HGNC ID: HGNC:7315 |
• CD22 means Cluster of Differentiation 22. Entrez Gene ID: 933. HGNC ID: HGNC: 1643 |
• CD123 means Cluster of Differentiation 123. Entrez Gene ID: 3563. HGNC ID: HGNC: 6012 |
• CLL1 means C-type lectin-like molecule. Entrez Gene ID: 160364. HGNC ID: HGNC: 31713 |
• CD3 means Cluster of Differentiation 3. Entrez Gene ID: 917. HGNC ID: HGNC: 1675 |
Schedule 1.129: Failed Target Criteria |
A Research Target shall be deemed a Failed Target if it satisfies at least one of the following conditions: |
1. Those Research Target Products generated and tested with respect to the Research Target campaign does not exhibit an appropriate in vitro selectivity index, defined as at least 10-fold difference in the potency of the Research Target Product on tumor cells expressing the Research Target vs. tumor cells lacking expre... |
2. Those Research Target Products that were advanced into in vivo studies with respect to the Research Target failed to show statistically significant efficacy as judged by comparison to the infusion of sCAR-T cells alone; or |
3. Failure of a Research Target Products with respect to the relevant Research Target to advance past a Decision Point, where the TD-JRC believes in good faith that no Research Target Product could be generated that would advance past such Decision Point given the then-current state of the art. |
Schedule 1.139: FTE Rates |
• For Calibr FTEs, as of the Original Execution Date: $315,000 |
• For AbbVie FTEs, as of the Original Execution Date: $375,000 |
Schedule 1.149: In-License Schedule |
License Agreement between The Scripps Research Institute and California Institute for Biomedical Research dated 1, 2015, as amended. |
Schedule 1.225: PRLR Switch Plan |
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