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C0000754
has_associated_morphology
C4509813
Congenital abnormal fusion
Congenital chorioretinal coloboma of right eye
null
null
C0000754
has_associated_morphology
C4509814
Congenital abnormal fusion
Congenital chorioretinal coloboma of bilateral eyes
null
null
C0000754
has_associated_morphology
C4509839
Congenital abnormal fusion
Hypotrichosis and intellectual disability syndrome Lopes type
null
Syndrome with characteristics of hypotrichosis, syndactyly, intellectual deficit and early eruption of teeth. It has been described in two patients. The mode of transmission appears to be autosomal recessive.
C0000754
has_associated_morphology
C4510303
Congenital abnormal fusion
Posterior fusion of lumbosacral vertebrae and blepharoptosis syndrome
null
Syndrome with characteristics of congenital ptosis and posterior fusion of the lumbosacral vertebrae. It has been described in a mother and her two daughters. Serum lactic dehydrogenase activity was elevated in the mother and 1 daughter.
C0000754
has_associated_morphology
C4510372
Congenital abnormal fusion
Polysomia
null
null
C0000754
has_associated_morphology
C4518569
Congenital abnormal fusion
Duplication of eyebrow and syndactyly syndrome
null
Syndrome with characteristics of partial duplication of the eyebrows and syndactyly of the fingers and toes. It has been described in three patients (a brother and sister and an isolated case). Skin hyperelasticity, hypertrichosis and long eyelashes and abnormal periorbital wrinkling were also reported in some of the p...
C0000754
has_associated_morphology
C4544150
Congenital abnormal fusion
Bilateral webbed toes of both feet
null
null
C0000754
has_associated_morphology
C4545230
Congenital abnormal fusion
Tibio-fibular synostosis
null
A rare non-syndromic limb malformation with characteristics of fusion of the proximal or distal tibial and fibular metaphysis and/or diaphysis. The disease is frequently associated with distal positioning of the proximal tibiofibular joint, leg length discrepancy, bowing of the fibula and valgus deformity of the knee.
C0000754
has_direct_morphology
C4545765
Congenital abnormal fusion
Repair of syndactyly with skin graft
null
null
C0000754
has_associated_morphology
C4706392
Congenital abnormal fusion
Isolated congenital syngnathia
null
A very rare developmental defect during embryogenesis with characteristics of varying degrees of congenital fusion (ranging from simple mucosal adhesions to extensive bony fusion) of mandible to maxilla that is not associated with any other malformations. Patients present with mouth opening limitation (which could rang...
C0000754
has_associated_morphology
C4706525
Congenital abnormal fusion
Syndactyly type 6
null
A rare genetic non-syndromic congenital limb malformation with characteristics of unilateral fusion of second to fifth fingers, amalgamation of distal phalanges in a knot-like structure, and second and third-toe fusion. Some individuals present only with webbing between second and third toes without involvement of fing...
C0000754
has_associated_morphology
C4706681
Congenital abnormal fusion
Symbrachydactyly of digit of hand
null
null
C0000754
has_associated_morphology
C4707866
Congenital abnormal fusion
Familial lambdoid synostosis
null
A rare genetic cranial malformation with characteristics of unilateral or bilateral synostosis of the lambdoid suture in multiple members of a single family. Unilateral cases typically present ipsilateral occipitomastoid bulge, compensatory contralateral parietal and frontal bossing, displacement of one ear, lateral de...
C0000754
has_associated_morphology
C4749852
Congenital abnormal fusion
Ectodermal dysplasia syndactyly syndrome
null
A rare genetic ectodermal dysplasia syndrome with characteristics of sparse to absent scalp hair, eyebrows, and eyelashes (with pili torti when present), widely spaced, conical-shaped teeth with peg-shaped, conical crowns and enamel hypoplasia and palmoplantar hyperkeratosis, associated with partial cutaneous syndactyl...
C0000754
has_associated_morphology
C4751207
Congenital abnormal fusion
Humeroradioulnar synostosis
null
An extremely rare genetic congenital joint formation defect disorder with characteristics of unilateral or bilateral fusion of the humerus, radius and ulnar bones, leading to loss of elbow motion and in most, functional arm incapacity. It may appear as distal humeral bifurcation with absent elbow joint and shortened ar...
C0000754
has_associated_morphology
C4751214
Congenital abnormal fusion
Bilateral radioulnar synostosis
null
null
C0000754
has_associated_morphology
C4751401
Congenital abnormal fusion
Bilateral tarsal coalitions of feet
null
null
C0000754
has_associated_morphology
C4751506
Congenital abnormal fusion
FBLN1-related developmental delay, central nervous system anomaly, syndactyly syndrome
null
A rare genetic multiple congenital anomalies/dysmorphic syndrome with characteristics of delayed motor development, intellectual disability, dysarthria, pseudobulbar signs, cryptorchidism, and syndactyly associated with a FLBN1 gene point mutation. Macular degeneration and signs of brain atrophy and spinal cord compres...
C0000754
has_associated_morphology
C5190737
Congenital abnormal fusion
Dobrow syndrome
null
A rare multiple congenital defects/dysmorphic syndrome with characteristics of variable degrees of bony syngnathia associated with variable additional abnormalities including growth retardation, intellectual disability, microcephaly, iris coloboma, nystagmus, deafness and vertebral segmentation defects. Also associated...
C0000754
has_associated_morphology
C5190852
Congenital abnormal fusion
Cloverleaf skull, asphyxiating thoracic dysplasia syndrome
null
A rare syndromic craniosynostosis with characteristics of prenatal presentation with cloverleaf skull, micromelia and asphyxiating thoracic dysplasia. Radiologic features include short ribs, horizontal roof of the acetabulum with a rounded median prominence and lateral spurs, deformed long bones with broad metaphyses a...
C0000754
has_associated_morphology
C5190993
Congenital abnormal fusion
Syndactyly, nystagmus syndrome due to 2q31.1 microduplication
null
A rare genetic chromosomal anomaly syndrome resulting from partial duplication of the long arm of chromosome 2 with characteristics of congenital pendular nystagmus associated with bilateral cutaneous syndactyly between the third and fourth fingers.
C0000754
has_associated_morphology
C5191039
Congenital abnormal fusion
Syndactyly, polydactyly, ear lobe syndrome
null
A rare genetic congenital limb malformation syndrome with characteristics of complete cutaneous syndactyly between toes 1-2, ulnar polydactyly (ranging from nubbins to an almost complete additional finger) and earlobe malformations. Additionally, abnormalities along the medial border of the foot are observed on X-ray i...
C0000754
has_associated_morphology
C5234850
Congenital abnormal fusion
Antley-Bixler Syndrome
null
A rare syndromic craniosynostosis characterized by craniosynostosis with midface hypoplasia, radiohumeral synostosis, femoral bowing and joint contractures.
C0000754
has_associated_morphology
C5397319
Congenital abnormal fusion
Syndactyly of toes with fusion of bones of toes of bilateral feet
null
null
C0000754
has_associated_morphology
C5437361
Congenital abnormal fusion
Bilateral syndactyly of toes
null
null
C0000754
has_associated_morphology
C5437904
Congenital abnormal fusion
Bilateral syndactyly of fingers with fusion of bones
null
null
C0000754
has_associated_morphology
C5438240
Congenital abnormal fusion
Bilateral humeroradial synostosis
null
null
C0000754
has_associated_morphology
C5438413
Congenital abnormal fusion
Fetal epignathus with conjoined twins
null
null
C0000754
has_associated_morphology
C5438468
Congenital abnormal fusion
Symbrachydactyly of bilateral hands and feet
null
null
C0000754
has_associated_morphology
C5438514
Congenital abnormal fusion
Simple syndactyly of toes of second web space of bilateral feet
null
null
C0000754
has_associated_morphology
C5438699
Congenital abnormal fusion
Bilateral congenital tibiofibular synostosis
null
null
C0000754
has_associated_morphology
C5438812
Congenital abnormal fusion
Pfeiffer syndrome type 1
null
null
C0000754
has_associated_morphology
C5438849
Congenital abnormal fusion
Pfeiffer syndrome type 2
null
null
C0000754
has_associated_morphology
C5438850
Congenital abnormal fusion
Pfeiffer syndrome type 3
null
null
C0000754
has_associated_morphology
C5438933
Congenital abnormal fusion
Simple syndactyly of toes of first web space of bilateral feet
null
null
C0000754
has_associated_morphology
C5438978
Congenital abnormal fusion
Bilateral humero-radio-ulnar synostosis
null
null
C0000754
has_associated_morphology
C5438980
Congenital abnormal fusion
Bilateral humero-ulnar synostosis
null
null
C0000754
has_associated_morphology
C5439182
Congenital abnormal fusion
Thoracoomphalopagus
null
null
C0000754
has_associated_morphology
C5574939
Congenital abnormal fusion
Timothy syndrome type 1
null
Timothy syndrome is a multi-system disorder with characteristics of cardiac, hand, facial and neurodevelopmental features that include QT prolongation, webbed fingers and toes, flattened nasal bridge, low-set ears, small upper jaw, thin upper lip, and characteristic features of autism or autistic spectrum disorders. Ti...
C0000754
has_associated_morphology
C5679809
Congenital abnormal fusion
Congenital radioulnar synostosis
null
null
C0000754
has_associated_morphology
C5681240
Congenital abnormal fusion
Short rib polydactyly syndrome type 5
null
A rare ciliopathy with major skeletal involvement characterized by short ribs, micromelia, limb bowing, polysyndactyly, absent ossification of the radii, tibiae and fibulae, as well as the bony elements of the hands and feet, and hypoplastic scapulae. Additional hallmarks of ciliopathic disease, such as laterality defe...
C0000754
has_associated_morphology
C5687227
Congenital abnormal fusion
Bilateral congenital abnormal fusion of carpal bones
null
null
C0000754
has_associated_morphology
C5687283
Congenital abnormal fusion
Congenital abnormal fusion of left carpal bones
null
null
C0000754
has_associated_morphology
C5687284
Congenital abnormal fusion
Congenital abnormal fusion of right carpal bones
null
null
C0000754
has_associated_morphology
C5779878
Congenital abnormal fusion
Triphalangeal thumb and polysyndactyly syndrome
null
A hand-foot malformation with characteristics of triphalangeal thumbs and pre and postaxial polydactyly, isolated syndactyly or complex polysyndactyly. It has been described in some large pedigrees. Clinical presentation is variable within families, ranging from mild to severe. Malformations of the feet are usually les...
C0000754
has_associated_morphology
C5816683
Congenital abnormal fusion
Ectodermal dysplasia, hyperhidrosis, cutaneous syndactyly syndrome
null
A rare ectodermal dysplasia syndrome characterised by hypotrichosis, tooth enamel hypoplasia, hypoplastic nails, palmoplantar keratoderma, hyperhidrosis on hands, face, and scalp, bilateral partial cutaneous syndactyly, and dysmorphic facial features with large prominent ear pinnae, pointed nose, and thin upper lips. A...
C0000754
replaces
C5921896
Congenital abnormal fusion
Abnormally fused structure
null
Fusion that has occurred in a structure that is not normally fused.
C0000765
mapped_from
C0332544
Excessive body weight gain
Abnormal weight gain
null
null
C0000765
clinically_associated_with
C0002965
Excessive body weight gain
Angina, Unstable
null
Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.
C0000765
clinically_associated_with
C0149973
Excessive body weight gain
Intrauterine pregnancy
null
null
C0000765
inverse_isa
C0740826
Excessive body weight gain
VITAL/MEAS PROBLEM
null
null
C0000765
has_manifestation
C2749022
Excessive body weight gain
Chromosome Xp11.23-P11.22 Duplication Syndrome
null
null
C0000765
possibly_equivalent_to
C0497406
Excessive body weight gain
Overweight
null
A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.
C0000765
has_risk_factor
C4060576
Excessive body weight gain
Risk for unstable blood glucose level
null
Susceptible to variation in serum levels of glucose from the normal range, which may compromise health.
C0000765
isa
C2220009
Excessive body weight gain
Excessive weight gain during pregnancy
null
null
C0000765
inverse_isa
C0043094
Excessive body weight gain
Weight Gain
null
Increase in BODY WEIGHT over existing weight.
C0000765
inverse_isa
C1290926
Excessive body weight gain
Body weight AND/OR growth problem
null
null
C0000765
isa
C2203026
Excessive body weight gain
weight gain greater than 7% in one year
null
null
C0000765
is_interpreted_by
C0005911
Excessive body weight gain
Body Weight Changes
null
A clinical manifestation consisting of alterations in an individual's weight from his or her norm.
C0000765
mapped_from
C0332544
Excessive body weight gain
Abnormal weight gain
null
null
C0000765
is_interpreted_by
C0424655
Excessive body weight gain
Weight trend
null
null
C0000765
interpretation_of
C0442802
Excessive body weight gain
Excessive (qualifier value)
null
Beyond normal limits; unrestrained.
C0000765
is_interpreted_by
C1261467
Excessive body weight gain
Body weight measure
null
null
C0000765
is_interpreted_by
C1285590
Excessive body weight gain
Weight gain (amount)
null
null
C0000765
interpretation_of
C2711672
Excessive body weight gain
Increased relative to previous
null
null
C0000766
co-occurs_with
C0003873
X-ray abnormal
Rheumatoid Arthritis
null
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have ...
C0000766
clinically_associated_with
C0011860
X-ray abnormal
Diabetes Mellitus, Non-Insulin-Dependent
null
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults...
C0000766
clinically_associated_with
C0014866
X-ray abnormal
Esophageal Stenosis
null
A stricture of the ESOPHAGUS. Most are acquired but can be congenital.
C0000766
co-occurs_with
C0027543
X-ray abnormal
Avascular necrosis of bone
null
Necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
C0000766
co-occurs_with
C0029443
X-ray abnormal
Osteomyelitis
null
INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.
C0000766
co-occurs_with
C0029453
X-ray abnormal
Osteopenia
null
A decrease in bone mineral density with a T-score via DEXA (dual-energy X-ray absorptiometry) bone scan between -1 and -2.5.
C0000766
co-occurs_with
C0033802
X-ray abnormal
Pseudogout
null
An acute episode of pain, swelling, and redness, sometimes associated with fever. It is caused by the deposition of calcium pyrophosphate crystals in the joints.
C0000766
clinically_associated_with
C0034079
X-ray abnormal
Nodule of lung
null
Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging. [https://orcid.org/0000-0002-4095-8489, PMID:26977460]
C0000766
clinically_associated_with
C0040128
X-ray abnormal
Thyroid Diseases
null
Pathological processes involving the THYROID GLAND.
C0000766
clinically_associated_with
C0546176
X-ray abnormal
sickle cell pain crisis
null
null
C0000766
inverse_isa
C0740845
X-ray abnormal
Imaging problem
null
null
C0000766
clinically_associated_with
C0741154
X-ray abnormal
AORTA ABDOMINAL ANEURYSM WITH THROMBUS
null
null
C0000766
co-occurs_with
C0743886
X-ray abnormal
FEMUR HEAD BONY INFARCT
null
null
C0000766
co-occurs_with
C0743894
X-ray abnormal
FEMUR LUCENCY
null
null
C0000766
co-occurs_with
C0744917
X-ray abnormal
HIP BONE ISLAND
null
null
C0000766
co-occurs_with
C0745998
X-ray abnormal
LUMBAR SPINE DEGENERATIVE CHANGES
null
null
C0000766
clinically_associated_with
C0749493
X-ray abnormal
TIBIA FRACTURE ORIF
null
null
C0000766
co-occurs_with
C0749500
X-ray abnormal
TIBIA MIDSHAFT FRACTURE
null
null
C0000766
co-occurs_with
C4551516
X-ray abnormal
Hip pain
null
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip. [https://orcid.org/0000-0002-0003-6754]
C0000766
classified_as
C0028315
X-ray abnormal
Nonspecific abnormal findings on radiological and other examination of other sites of body
null
null
C0000766
classified_as
C0159085
X-ray abnormal
Nonspecific (abnormal) findings on radiological and other examination of body structure
null
null
C0000766
classified_as
C0159093
X-ray abnormal
Nonspecific (abnormal) findings on radiological and other examination of musculoskeletal system
null
null
C0000767
classifies
C0034933
Reflexes abnormal NEC
Reflex, Abnormal
null
An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
C0000767
has_member
C1964000
Reflexes abnormal NEC
Guillain-Barre syndrome (SMQ)
null
Guillain-Barre syndrome (GBS) is an immune-mediated, acute inflammatory demyelinating polyneuropathy (AIDP). Condition commonly follows a viral or mycoplasmal illness affecting the upper respiratory or alimentary tracts. Other antecedent events include certain vaccinations. Immune responses directed toward the infectin...
C0000767
has_member
C1964001
Reflexes abnormal NEC
Noninfectious encephalitis (SMQ)
null
Encephalitis is defined as inflammation of the brain. Commonly has an infectious etiology. May also be drug-induced (focus of this SMQ). Mixed disorders such as encephalomyelitis, encephalomyeloradiculitis, or encephalo-myelopathy may present with overlapping symptoms. Signs and symptoms include: acute febrile illness ...
C0000767
has_member
C1964003
Reflexes abnormal NEC
Noninfectious meningitis (SMQ)
null
Meningitis is defined as an inflammation of the meninges. Commonly has an infectious etiology. May also be drug-induced (focus of this SMQ). 1) Aseptic meningitis: Characterized by CSF mononuclear pleocytosis and an absence of bacteria on examination and culture. May be caused by viruses. Rare but well-recognized compl...
C0000768
co-occurs_with
C0013080
Congenital Abnormality
Down Syndrome
Malformations of organs or body parts during development in utero.
A chromosome disorder associated either with an extra CHROMOSOME 21 or an effective TRISOMY for chromosome 21. Clinical manifestations include HYPOTONIA, short stature, BRACHYCEPHALY, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger...
C0000768
co-occurs_with
C0018989
Congenital Abnormality
Hemiparesis
Malformations of organs or body parts during development in utero.
Weakness or incomplete paralysis of either the left or right side of the body.
C0000768
clinically_associated_with
C0032961
Congenital Abnormality
Pregnancy
Malformations of organs or body parts during development in utero.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
C0000768
co-occurs_with
C0080178
Congenital Abnormality
Spina Bifida
Malformations of organs or body parts during development in utero.
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete f...
C0000768
clinically_associated_with
C0149973
Congenital Abnormality
Intrauterine pregnancy
Malformations of organs or body parts during development in utero.
null
C0000768
clinically_associated_with
C0242356
Congenital Abnormality
Databases
Malformations of organs or body parts during development in utero.
An information set with a regular structure. Although it can be applied to any set of information the term was invented to refer to computerized data, and is used almost exclusively in computing.
C0000768
co-occurs_with
C0410916
Congenital Abnormality
Neonatal Death
Malformations of organs or body parts during development in utero.
The death of a live-born INFANT less than 28 days of age.
C0000768
inverse_isa
C0566639
Congenital Abnormality
Pregnancy problem
Malformations of organs or body parts during development in utero.
null
C0000768
co-occurs_with
C0596706
Congenital Abnormality
Hip surgery
Malformations of organs or body parts during development in utero.
procedures performed on the hip, used in the treatment of disease, injuries, or deformities.