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C0000768
isa
C2317185
Congenital Abnormality
Congenital malformation of sphenoid wing
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2362640
Congenital Abnormality
Neuronal choristoma
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2363280
Congenital Abnormality
Cervical auricle (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2675336
Congenital Abnormality
Duplication 15q11-q13 Syndrome
Malformations of organs or body parts during development in utero.
Syndrome characterized by neurobehavioral disorders, hypotonia, cognitive deficit, language delay and seizures. Prevalence is unknown. The clinical picture is highly variable even within the same family. Paternal duplications are rarely symptomatic (developmental delay/ behavioral disorders). The syndrome is due to int...
C0000768
isa
C2675369
Congenital Abnormality
Chromosome 22q11.2 Microduplication Syndrome
Malformations of organs or body parts during development in utero.
The association of a broad clinical spectrum and a duplication of the region that is deleted in patients with DiGeorge or velocardiofacial, establishing a complementary duplication syndrome. The clinical presentation of patients is extremely variable and shares features with 22q11.2 deletion syndromes including heart d...
C0000768
isa
C2675897
Congenital Abnormality
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb
Malformations of organs or body parts during development in utero.
1q21.1 microdeletion syndrome is a newly described recurrent deletion syndrome with variable clinical manifestations but without the clinical picture of thrombocytopenia - absent radius (TAR) syndrome.
C0000768
isa
C2677613
Congenital Abnormality
Chromosome 15q13.3 Microdeletion Syndrome
Malformations of organs or body parts during development in utero.
15q13.3 microdeletion (microdel15q13.3) syndrome is characterized by a wide spectrum of neurodevelopmental disorders with no or subtle dysmorphic features.
C0000768
isa
C2699510
Congenital Abnormality
Congenital cleft hand (disorder)
Malformations of organs or body parts during development in utero.
A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middle fingers as far as oligo- or monodactyl hands. [https://orcid.org/0009-0006-4530-3154]
C0000768
isa
C2750325
Congenital Abnormality
Oculootodental syndrome
Malformations of organs or body parts during development in utero.
A contiguous gene syndrome comprising otodental syndrome (globodontia and sensorineural high-frequency hearing deficit) associated with eye abnormalities typically including iris and chorioretinal coloboma and sometimes microcornea, microphthalmos, lenticular opacity, lens coloboma and iris pigment epithelial atrophy.
C0000768
isa
C2919547
Congenital Abnormality
Common atrioventricular orifice in double inlet ventricle
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2931507
Congenital Abnormality
Sternal cleft
Malformations of organs or body parts during development in utero.
The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum. [https://orcid.org/0000-0002-0736-9199]
C0000768
isa
C2931794
Congenital Abnormality
Chromosome 10, uniparental disomy of
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome with a highly variable phenotype. The principle characteristics are growth delay, craniofacial dysmorphism (including prominent forehead, hypertelorism, upslanting palpebral fissures, blepharophimosis, low-set malformed large ears, high arched palate, cleft lip/palate, retrognathia) ...
C0000768
isa
C2931816
Congenital Abnormality
Chromosome 2, monosomy 2q24
Malformations of organs or body parts during development in utero.
A chromosomal anomaly consisting of a partial long arm deletion of chromosome 2 with clinical characteristics of a wide range of manifestations (depending on the specific region deleted) which can include seizures, microcephaly, dysmorphic features, cleft palate, eye abnormalities (coloboma, cataract and microphthalmia...
C0000768
isa
C2931817
Congenital Abnormality
Chromosome 2q37 deletion syndrome
Malformations of organs or body parts during development in utero.
A syndrome of high phenotypic variability caused by contiguous gene deletions in 2q37. The inheritance is autosomal dominant. The condition may be characterized by brachydactly type E; mental retardation; short stature; and other skeletal, cardiovascular, and neurologic manifestations.
C0000768
isa
C2939133
Congenital Abnormality
Accessory liver (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2981132
Congenital Abnormality
Shell teeth
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3164519
Congenital Abnormality
Commissural fusion of truncal valve
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3164537
Congenital Abnormality
Ventricular septal defect with malaligned outlet septum
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3164757
Congenital Abnormality
Congenital stenosis of mitral subvalvular apparatus
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3532337
Congenital Abnormality
Congenital subpulmonary stenosis due to restrictive ventricular defect associated with functionally univentricular heart
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3536714
Congenital Abnormality
Renal dysplasia
Malformations of organs or body parts during development in utero.
The presence of developmental dysplasia of the kidney. [https://orcid.org/0000-0002-0736-9199]
C0000768
isa
C3537055
Congenital Abnormality
Pilonidal abscess
Malformations of organs or body parts during development in utero.
A hair-containing cyst or sinus usually in the coccygeal region. [https://orcid.org/0000-0002-0736-9199]
C0000768
isa
C3662130
Congenital Abnormality
Congenital hypoplasia of brain
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3662134
Congenital Abnormality
Cystic malformation of posterior fossa
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3697355
Congenital Abnormality
16p11.2 Deletion Syndrome
Malformations of organs or body parts during development in utero.
A microdeletion at 16p11.2, characterized by a predisposition to obesity, developmental delay and autism spectrum disorders.
C0000768
isa
C3711376
Congenital Abnormality
Isodicentric Chromosome 15 Syndrome
Malformations of organs or body parts during development in utero.
A chromosomal disorder with distinctive clinical findings characterized by early central hypotonia, developmental delay and intellectual deficit, epilepsy, and autistic behavior. Facial dysmorphism is absent or subtle and major malformations are rare. The syndrome is usually sporadic and not inherited and results from ...
C0000768
isa
C4225255
Congenital Abnormality
PMP22-RAI1 contiguous gene duplication syndrome
Malformations of organs or body parts during development in utero.
A rare partial duplication of the long arm of chromosome 17 characterised by a combination of features of 17p11.2 microduplication syndrome and Charcot-Marie-Tooth disease type 1A. Patients present with infantile onset of global developmental delay, hypotonia, feeding difficulties, and failure to thrive, as well as chi...
C0000768
isa
C4273657
Congenital Abnormality
Proximal 16p11.2 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A chromosomal anomaly with characteristics of developmental and language delays, mild intellectual disability, social impairments (autism spectrum disorders), mild variable dysmorphism and predisposition to obesity. The proximal 16p11.2 microdeletion syndrome most commonly refers to a distinct deletion of approximately...
C0000768
isa
C4274328
Congenital Abnormality
FRAXE intellectual disability syndrome
Malformations of organs or body parts during development in utero.
FRAXE is a form of nonsyndromic X-linked mental retardation with characteristic of mild intellectual deficit. The estimated prevalence in the general population is between 1 in 100,000 and 1 in 150,000. FRAXE manifests in individuals with more than 200 CCG repeats in the 5' UTR of the AFF2 gene (Xq28).
C0000768
isa
C4274329
Congenital Abnormality
FRAXF syndrome
Malformations of organs or body parts during development in utero.
FRAXF syndrome was originally identified in a family with developmental delay and an expanded CCG repeat at the folate-sensitive FRAXF fragile site. Since this initial description, FRAXF has been associated with a range of manifestations but no clear phenotype has been established. Prevalence is unknown. The FRAXF frag...
C0000768
isa
C4303435
Congenital Abnormality
Infection causing congenital anomaly
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4303530
Congenital Abnormality
Congenital anomaly of mother complicating pregnancy
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4304578
Congenital Abnormality
1p21.3 microdeletion syndrome
Malformations of organs or body parts during development in utero.
An extremely rare chromosomal anomaly with characteristics of severe speech and language delay, intellectual deficiency, autism spectrum disorder. Less than 10 cases have been reported to date. The syndrome is caused by a hemizygous interstitial microdeletion on the short arm of chromosome 1, occurring mostly de novo, ...
C0000768
isa
C4304594
Congenital Abnormality
16q24.3 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A recently described syndrome associated with variable developmental delay, facial dysmorphism, seizures and autistic spectrum disorder. This syndrome is caused by an interstitial deletion encompassing 16q24.3. They vary in size the common region of overlap is only 90 kb and comprises two candidates genes, ANKRD11 (Ank...
C0000768
isa
C4304595
Congenital Abnormality
16p13.11 microduplication syndrome
Malformations of organs or body parts during development in utero.
A recently described syndrome associated with variable clinical features including behavioral abnormalities, developmental delay, congenital heart defects and skeletal anomalies. This syndrome is caused by interstitial duplications encompassing 16p13.11. The size of the rearrangements is variable. The underlying mechan...
C0000768
isa
C4510307
Congenital Abnormality
Congenital hypoplasia of patella
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4518344
Congenital Abnormality
12q15q21.1 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from a partial deletion of the long arm of chromosome 12 with a highly variable phenotype. The disorder has typical characteristics of developmental delay, learning disability, intrauterine and postnatal growth retardation, and mild facial dysmorphism that changes with age....
C0000768
isa
C4518821
Congenital Abnormality
16p11.2p12.2 microduplication syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from the partial duplication of the short arm of chromosome 16. The disorder has a highly variable phenotype with typical characteristics of developmental/psychomotor delay (particularly of speech), intellectual disability, autism spectrum disorder, dysmorphic facial featur...
C0000768
isa
C4518824
Congenital Abnormality
Distal 16p11.2 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from the partial deletion of the short arm of chromosome 16. The disease has a highly variable phenotype with typical characteristics of developmental delay, mild intellectual disability and autism spectrum disorder. Macrocephaly (apparent by 2 years of age), structural bra...
C0000768
isa
C4521042
Congenital Abnormality
Complete Trisomy 21 Syndrome
Malformations of organs or body parts during development in utero.
A syndrome characterized by the presence of three complete copies of genetic material for chromosome 21, instead of the normal two. It leads to a variety of abnormalities that include mental retardation, macroglossia, microgenia, epicanthic eyelids, and a single transverse palmar crease.
C0000768
isa
C4551491
Congenital Abnormality
Congenital absence of penis
Malformations of organs or body parts during development in utero.
An extremely rare congenital abnormality characterized by the complete absence of the penis. It may be associated with other genitourinary abnormalities.
C0000768
isa
C4551722
Congenital Abnormality
Encephalocele
Malformations of organs or body parts during development in utero.
A congenital neural tube closure defect resulting in the protrusion of the brain through a skull opening. When the protrusion includes the meninges, the term encephalomeningocele is used.
C0000768
isa
C4706364
Congenital Abnormality
Distal trisomy 7p syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from the partial duplication of the short arm of chromosome 7. The disorder has a highly variable phenotype with typical characteristics of severe to profound psychomotor delay, intellectual disability, dysmorphic features (including dolichocephaly, microbrachycephaly, high...
C0000768
isa
C4706935
Congenital Abnormality
Distal trisomy 20q syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from partial trisomy of the long arm of chromosome 20 with high phenotypic variability. The disease has characteristics of neurodevelopmental delay, cardiac malformations (ventricular septal defect, coarctation of aorta) and facial dysmorphism (large/high forehead, micropht...
C0000768
isa
C4707332
Congenital Abnormality
Proximal 16p11.2 microduplication syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly syndrome resulting from a partial duplication of the short arm of chromosome 16. The disease has characteristics of developmental delay and intellectual disability of a highly variable degree, autism spectrum, obsessive-compulsive, attention deficit hyperactivity disorder, speech articulation...
C0000768
isa
C4708545
Congenital Abnormality
15q13.3 microduplication syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4721530
Congenital Abnormality
Congenital hypotrichia
Malformations of organs or body parts during development in utero.
A congenital condition, usually due to genetic aberrations, that is characterized by a lack of hair growth on the head and/or body.
C0000768
isa
C4749464
Congenital Abnormality
16q24.1 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A partial autosomal monosomy with clinical characteristics of lethal pulmonary disease that presents as severe respiratory distress and refractory pulmonary hypertension within a few hours after birth and typically results in death from respiratory failure within the first months of life. Characteristic histological fe...
C0000768
isa
C4749581
Congenital Abnormality
Distal monosomy 12p
Malformations of organs or body parts during development in utero.
A rare partial autosomal monosomy with characteristics of language development delay with childhood apraxia of speech, mild intellectual disability, autistic spectrum disorder, attention deficit hyperactivity disorder, anxiety and mildly dysmorphic nonspecific features. Additional clinical features may include muscular...
C0000768
isa
C4749584
Congenital Abnormality
Distal 7q11.23 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly characterized by epilepsy, neurodevelopmental disorder variably including developmental delays and intellectual disabilities of variable severity, learning disability and neurobehavioral abnormalities (autism spectrum disorder, hyperactivity, impulsivity, aggression, self-abusive behaviors, d...
C0000768
isa
C4749854
Congenital Abnormality
15q11.2 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A rare partial autosomal monosomy with a variable phenotypic expression and reduced penetrance associated with an increased susceptibility to neuropsychiatric or neurodevelopmental disorders including delayed psychomotor development, speech delay, autism spectrum disorder, attention deficit-hyperactivity disorder, obse...
C0000768
isa
C4750782
Congenital Abnormality
Distal 7q11.23 microduplication syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly with characteristics of a predominantly neuropsychiatric phenotype with a few dysmorphic features. Speech delay, learning difficulties, attention deficit hyperactivity disorder, bipolar disorder and aggressiveness have been reported.
C0000768
isa
C4750783
Congenital Abnormality
7q31 microdeletion syndrome
Malformations of organs or body parts during development in utero.
A rare chromosomal anomaly with characteristics of speech and language disorder, predominantly presenting as an apraxia of speech, sometimes associated with oral motor dyspraxia, dysarthria, receptive and expressive language disorder, and hearing loss. Individuals with larger deletions in this region have also been rep...
C0000768
isa
C4751127
Congenital Abnormality
Distal Xq28 microduplication syndrome
Malformations of organs or body parts during development in utero.
A rare hereditary syndromic intellectual disability characterised by cognitive impairment, behavioural and psychiatric problems, recurrent infections, atopic diseases and distinctive facial features in males. Females are clinically asymptomatic or mildly affected presenting mild learning difficulties and facial dysmorp...
C0000768
isa
C5190515
Congenital Abnormality
Distal monosomy 7p syndrome
Malformations of organs or body parts during development in utero.
A partial autosomal monosomy with characteristics of developmental delay and intellectual disability, digital anomalies, congenital heart and urogenital anomalies and specific craniofacial features commonly including craniosynostosis.
C0000768
isa
C5401310
Congenital Abnormality
Congenital malformation of lymphatic system of cervicofacial region
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5401456
Congenital Abnormality
17q11 deletion syndrome
Malformations of organs or body parts during development in utero.
17q11 microdeletion syndrome is a rare severe form of neurofibromatosis type 1 characterized by mild facial dysmorphism, developmental delay, intellectual disability, increased risk of malignancies, and a large number of neurofibromas.
C0000768
isa
C5437215
Congenital Abnormality
Congenital malformation caused by valproic acid
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437478
Congenital Abnormality
11p15 duplication syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437536
Congenital Abnormality
17q23.1-q23.2 duplication syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437539
Congenital Abnormality
7p21.1 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437540
Congenital Abnormality
9p24.3 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437542
Congenital Abnormality
9q34 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437624
Congenital Abnormality
17q24-qter duplication syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437625
Congenital Abnormality
20p12.2 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437630
Congenital Abnormality
3p25.3 deletion syndrome
Malformations of organs or body parts during development in utero.
3p25.3 microdeletion syndrome is a rare chromosomal anomaly characterised by intellectual disability, epilepsy or EEG abnormalities, poor speech, ataxia, and stereotypic hand movements.
C0000768
isa
C5437631
Congenital Abnormality
5q22.2 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5437632
Congenital Abnormality
7p12-p14 deletion syndrome
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5438645
Congenital Abnormality
Paternal 14q32.2 microdeletion
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5441518
Congenital Abnormality
Supernumerary eye muscle
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5687435
Congenital Abnormality
Congenital anomaly of craniovertebral junction
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C5848202
Congenital Abnormality
Congenital dilatation of lobar intrahepatic bile duct
Malformations of organs or body parts during development in utero.
A rare genetic hepatic disease characterized by multiple segmental cystic dilatations of both central and smaller peripheral bile ducts associated with congenital hepatic fibrosis. Age of symptom onset is variable, as is disease progression. Patients present recurrent cholangitis, hepatolithiasis, and cholecystolithias...
C0000768
inverse_isa
C0008073
Congenital Abnormality
Developmental Disabilities
Malformations of organs or body parts during development in utero.
Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in thes...
C0000768
isa
C0344464
Congenital Abnormality
Acephalothorax
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C2957119
Congenital Abnormality
congenital anomalies of face and neck corrected
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C3649623
Congenital Abnormality
congenital malformations of sense organs, (corrected)
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4027527
Congenital Abnormality
ultrasound fetal posterior cranial fossa hypoplastic
Malformations of organs or body parts during development in utero.
null
C0000768
isa
C4536118
Congenital Abnormality
congenital absence of urinary organ
Malformations of organs or body parts during development in utero.
null
C0000768
replaced_by
C0026505
Congenital Abnormality
Monster (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
possibly_equivalent_to
C0026505
Congenital Abnormality
Monster (disorder)
Malformations of organs or body parts during development in utero.
null
C0000768
replaced_by
C0158795
Congenital Abnormality
Other and unspecified congenital anomalies
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0161951
Congenital Abnormality
Correction of clubfoot
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0188772
Congenital Abnormality
Reconstruction of toe for macrodactyly with bone resection
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0188774
Congenital Abnormality
Reconstruction of cleft foot
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0188860
Congenital Abnormality
Tendon transfer and arthrodesis to correct claw toe
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0188862
Congenital Abnormality
Modified Johanson operation for claw toe with arthrodesis
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0188865
Congenital Abnormality
Soft tissue release for correction of congenital deformity of forefoot
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0192325
Congenital Abnormality
Correction of esophageal atresia
Malformations of organs or body parts during development in utero.
null
C0000768
possibly_equivalent_to
C0266660
Congenital Abnormality
Triplet monster, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
possibly_equivalent_to
C0266665
Congenital Abnormality
Single monster, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
possibly_equivalent_to
C0266685
Congenital Abnormality
double; monster
Malformations of organs or body parts during development in utero.
null
C0000768
possibly_equivalent_to
C0266723
Congenital Abnormality
Compound monster, NOS
Malformations of organs or body parts during development in utero.
null
C0000768
associated_morphology_of
C0332447
Congenital Abnormality
Morphologically abnormal structure (morphologic abnormality)
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0399734
Congenital Abnormality
Repair of congenital atresia of pylorus
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0407473
Congenital Abnormality
Chiari osteotomy for congenital deformity of hip
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0407477
Congenital Abnormality
Salter osteotomy for congenital deformity of hip
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0407481
Congenital Abnormality
Triple pelvic osteotomy for congenital dislocation of the hip
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0408930
Congenital Abnormality
Correction of congenital deformity of upper limb
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0408931
Congenital Abnormality
Correction of congenital deformity of shoulder or upper arm
Malformations of organs or body parts during development in utero.
null
C0000768
has_focus
C0408932
Congenital Abnormality
Correction of obstetric palsy
Malformations of organs or body parts during development in utero.
null