CUI1 stringlengths 8 8 | RELA stringlengths 3 54 | CUI2 stringlengths 8 8 | Name1 stringlengths 1 2.86k ⌀ | Name2 stringlengths 1 2.86k ⌀ | Def1 stringlengths 1 8.95k ⌀ | Def2 stringlengths 1 8.95k ⌀ |
|---|---|---|---|---|---|---|
C0000300 | mapped_to | C0163738 | 2-Naphthylamine | amido-G-acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0164690 | 2-Naphthylamine | 2-amino-7-(bis(2-chloroethyl)amino)-1,2,3,4-tetrahydro-2-naphthoic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0251248 | 2-Naphthylamine | prolyl-beta-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0258106 | 2-Naphthylamine | N-hydroxy-2-naphthylamine DNA adduct | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0291712 | 2-Naphthylamine | 7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0295470 | 2-Naphthylamine | di-2-naphthylurea | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0378300 | 2-Naphthylamine | benzyloxycarbonyl-alanyl-alanyl-lysyl-4-methoxy-2-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0384312 | 2-Naphthylamine | N,N-di-n-propyl-5,6,7,8-tetrahydro-1H-benz(f)benzimidazol-6-ylamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0533708 | 2-Naphthylamine | patman | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0536167 | 2-Naphthylamine | glycyl-arginyl-4-methoxy-beta-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0540226 | 2-Naphthylamine | RPR 114334 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0601957 | 2-Naphthylamine | 2-acetylaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0608696 | 2-Naphthylamine | 6-propionyl-2-(dimethylamino)naphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0612498 | 2-Naphthylamine | N-hydroxy-2-naphthylamine-N-glucuronide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0614440 | 2-Naphthylamine | 2-amino-5,8-dimethoxy-6-methyl-1,2-dihydronaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0615373 | 2-Naphthylamine | badische acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0616240 | 2-Naphthylamine | 2-amino-1,2-dihydronaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0628139 | 2-Naphthylamine | SK&F 88444 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0629960 | 2-Naphthylamine | 2-amino-5-(bis(2-chloroethyl)amino)-1,2,3,4-tetrahydro-2-naphthoic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0631925 | 2-Naphthylamine | prodan-phosphatidylcholine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0633656 | 2-Naphthylamine | benzyloxycarbonyl-arginyl--glycyl-phenylalanyl-phenylalanyl-proline-4-methoxy-2-naphthylamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0633660 | 2-Naphthylamine | benzyloxycarbonyl-arginyl-glycyl-phenylalanyl-phenylalanyl-leucine-4-methoxy-2-naphthylamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0636353 | 2-Naphthylamine | succinyl-alanyl-alanyl-phenylalanyl-4-methoxy-2-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0643948 | 2-Naphthylamine | succinyl-phenylalanyl-leucyl-phenylalanine-4-methoxynaphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0656578 | 2-Naphthylamine | lysine-2-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0657924 | 2-Naphthylamine | glutaryl-alanyl-alanyl-phenylalanyl-4-methoxy-2-naphthylamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0668666 | 2-Naphthylamine | N-propyl-N-(6-(2-(2-oxo-3H-1,3-benzothiazol-6-yl)ethylamino)hexyl)-5,6-dihydroxy-1,2,3,4-tetrahydro-2-naphthylamine dihydrobromide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0668669 | 2-Naphthylamine | N-propyl-N-(6-(2-(3,5-dihydroxyphenyl)ethylamino)hexyl)-5,6-dihydroxy-1,2,3,4-tetrahydro-2-naphthylamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0670615 | 2-Naphthylamine | 2-aminotetralin-2-carboxylic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0671782 | 2-Naphthylamine | 4-((3-amino-2-naphthyl)aminomethyl)benzoic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0671784 | 2-Naphthylamine | ethyl 4-((3-amino-2-naphthyl)aminomethyl)benzoate | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0760180 | 2-Naphthylamine | alanyl-4-methoxy-2-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0762239 | 2-Naphthylamine | 2-(1,1-dicyanopropenyl-2-)-6-dimethylaminonaphthaleney | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0893584 | 2-Naphthylamine | succinyl-alanyl-alanyl-asparaginyl-4-methoxy-2-naphthylamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0909880 | 2-Naphthylamine | 6-bromoacetyl-2-dimethylaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C0967167 | 2-Naphthylamine | Z7760 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1100130 | 2-Naphthylamine | 2,3-diamino-1,4-dibromonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1137068 | 2-Naphthylamine | PD 148903 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1137288 | 2-Naphthylamine | aladan | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1137968 | 2-Naphthylamine | 6-hydroxy-2-aminotetralin-2-carboxylic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1174719 | 2-Naphthylamine | 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1312553 | 2-Naphthylamine | 6-chloroacetyl-2-dimethylaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1451325 | 2-Naphthylamine | C,C,C-trifluoro-N-(5-(2-pyridin-2-ylvinyl)naphthalen-2-yl)methanesulfonamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1529892 | 2-Naphthylamine | 1-(2-aminonaphth-1-yl)-2-naphthol | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1700955 | 2-Naphthylamine | 1,8-diaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1722368 | 2-Naphthylamine | 1,5-diaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C1957094 | 2-Naphthylamine | elisabethamine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C2714202 | 2-Naphthylamine | N,N'-bis-(2-pyridinecarboxaldimine)-1,8-diaminonaphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C2714211 | 2-Naphthylamine | NCI 83633 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C2742078 | 2-Naphthylamine | 2-naphthylamine 3,6,8-trisulfonic acid | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C2973568 | 2-Naphthylamine | 1-(4-sulfanatobutyl)-4-(beta-(2-(di-n-butylamino)-6-naphthyl)butadienyl)quinolinium betaine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3181321 | 2-Naphthylamine | 3-(methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino)-1-indanone | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3252821 | 2-Naphthylamine | 2,2-dimethyl-3-(4-(naphthalen-2-ylamino)phenyl)-3-(1,2,4)triazol-1-yl-propionic acid methyl ester | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3657023 | 2-Naphthylamine | 6-(6-hydroxybenzo(d)thiazol-2'-yl)-2-(N,N-dimethylamino)naphthalene | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3658549 | 2-Naphthylamine | N-(3,4-dihydronaphthalen-2-yl)amide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3850691 | 2-Naphthylamine | N-acetylaladanamide | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3851190 | 2-Naphthylamine | ethyl 2-(naphthalen-2-ylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3851875 | 2-Naphthylamine | 4-(3'-bromophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C3852512 | 2-Naphthylamine | dasabuvir | A naphthalene derivative with carcinogenic action. | A non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intracellular uptake, dasabuvir binds HCV NS5B polymerase and blocks viral RNA synthesis and replication. The HCV NS5B protein is essential for the replication of the HCV RNA genome. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of hepatocellular carcinoma (HCC). |
C0000300 | mapped_to | C3885662 | 2-Naphthylamine | 1-O-(7'-N,N-dimethylamino-3'-pentadecanoyl-1'-naphthyl)-2-O-methyl-sn-glycerophosphocholine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4041608 | 2-Naphthylamine | MitoBlue | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4079393 | 2-Naphthylamine | 2-(5-(6-(dimethylamino)naphthalen-2-yl)penta-2,4-dien-1-ylidene)malononitrile | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4079394 | 2-Naphthylamine | 2-(3-(6-(dimethylamino)naphthalen-2-yl)allylidene)malononitrile | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4277211 | 2-Naphthylamine | 5-(2'-fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4278206 | 2-Naphthylamine | PA024 compound | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4278843 | 2-Naphthylamine | YW3-56 | A naphthalene derivative with carcinogenic action. | null |
C0000300 | mapped_to | C4309942 | 2-Naphthylamine | diethyl 6-(dimethylamino)naphthalene-2,3-dicarboxylate | A naphthalene derivative with carcinogenic action. | null |
C0000300 | inverse_isa | C1711315 | 2-Naphthylamine | Carcinogenic Aromatic Amine | A naphthalene derivative with carcinogenic action. | Potentially cancer-causing compound containing amine with an aromatic ring substituted for one or more of its hydrogen atoms, i.e., -NH2, -NH- or nitrogen group(s) attached to an aromatic hydrocarbon, whose structure usually contains one or more benzene rings. This group includes many industrial and tobacco carcinogens. (NCI05) |
C0000300 | subset_includes_concept | C1880653 | 2-Naphthylamine | FDA Established Names and Unique Ingredient Identifier Codes Terminology | A naphthalene derivative with carcinogenic action. | The terminology that includes terms pertaining to FDA/USP Substance Registration System (SRS), which is to support health information technology initiatives by generating unique ingredient identifiers (UNIIs) for substances in drugs, biologics, foods, and devices. |
C0000300 | subset_includes_concept | C4745185 | 2-Naphthylamine | CPTAC Terminology | A naphthalene derivative with carcinogenic action. | Terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC). |
C0000300 | subset_includes_concept | C4745186 | 2-Naphthylamine | CPTAC Baseline Medical Forms Terminology | A naphthalene derivative with carcinogenic action. | Terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) with the focus on obtaining data for baseline medical forms. |
C0000300 | subset_includes_concept | C4763397 | 2-Naphthylamine | CPTAC Environmental/Occupational Exposure Codelist | A naphthalene derivative with carcinogenic action. | Terminology used to support the collection of patient environmental and occupational hazardous exposure data by CPTAC. |
C0000300 | subset_includes_concept | C4764267 | 2-Naphthylamine | CPTAC Codelists Terminology | A naphthalene derivative with carcinogenic action. | Terminology used to support the various lists of data useful for tracking trends by CPTAC. |
C0000300 | subset_includes_concept | C4764391 | 2-Naphthylamine | CPTAC Medical History Form | A naphthalene derivative with carcinogenic action. | Terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) with the focus on Medical History Form data. |
C0000300 | inverse_isa | C0000102 | 2-Naphthylamine | 1-Naphthylamine | A naphthalene derivative with carcinogenic action. | A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic. |
C0000300 | inverse_isa | C0007090 | 2-Naphthylamine | Carcinogens | A naphthalene derivative with carcinogenic action. | Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. |
C0000300 | inverse_isa | C0027375 | 2-Naphthylamine | naphthalene | A naphthalene derivative with carcinogenic action. | A white, volatile, solid polycyclic hydrocarbon with a strong mothball odor. Naphthalene is obtained from either coal tar or petroleum distillation and is primarily used to manufacture phthalic anhydride, but is also used in moth repellents. Exposure to naphthalene is associated with hemolytic anemia, damage to the liver and neurological system, cataracts and retinal hemorrhage. Naphthalene is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing laryngeal and colorectal cancer. (NCI05) |
C0000300 | inverse_isa | C0578148 | 2-Naphthylamine | Amine and/or amine derivative | A naphthalene derivative with carcinogenic action. | null |
C0000300 | disposition_of | C4521889 | 2-Naphthylamine | Carcinogen (disposition) | A naphthalene derivative with carcinogenic action. | A substance that increases the risk of neoplasms in humans or animals either by directly affecting DNA or inducing neoplasms by other mechanisms |
C0000324 | mapped_to | C0527126 | 20-Hydroxysteroid Dehydrogenases | progesterone 20-keto-reductase | A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53). | null |
C0000324 | mapped_to | C0758903 | 20-Hydroxysteroid Dehydrogenases | 3 alpha-beta, 20 beta-hydroxysteroid dehydrogenase | A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53). | null |
C0000325 | inverse_isa | C0032458 | 20-Methylcholanthrene | Polycyclic Hydrocarbons, Aromatic | A polycyclic aromatic hydrocarbon that consists of five fused rings with carcinogenic activity. 20-Methylcholanthrene is often used in experimental cancer studies. | Aromatic hydrocarbons that contain extended fused-ring structures. |
C0000325 | subset_includes_concept | C1880653 | 20-Methylcholanthrene | FDA Established Names and Unique Ingredient Identifier Codes Terminology | A polycyclic aromatic hydrocarbon that consists of five fused rings with carcinogenic activity. 20-Methylcholanthrene is often used in experimental cancer studies. | The terminology that includes terms pertaining to FDA/USP Substance Registration System (SRS), which is to support health information technology initiatives by generating unique ingredient identifiers (UNIIs) for substances in drugs, biologics, foods, and devices. |
C0000334 | inverse_isa | C0042890 | 24,25-Dihydroxyvitamin D 3 | Vitamins | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body. |
C0000334 | inverse_isa | C1563726 | 24,25-Dihydroxyvitamin D 3 | Bone Density Conservation Agents | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. |
C0000334 | inverse_isa | C4704738 | 24,25-Dihydroxyvitamin D 3 | Calcium-Regulating Hormones and Agents | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. |
C0000334 | mapped_to | C3491187 | 24,25-Dihydroxyvitamin D 3 | 4,25-dihydroxyvitamin D3 | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000334 | associated_with | C0523704 | 24,25-Dihydroxyvitamin D 3 | Hydroxycalcidiol measurement | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000334 | inverse_isa | C0042866 | 24,25-Dihydroxyvitamin D 3 | vitamin D | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE. |
C0000334 | has_component | C0523704 | 24,25-Dihydroxyvitamin D 3 | Hydroxycalcidiol measurement | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000334 | has_measured_component | C0523704 | 24,25-Dihydroxyvitamin D 3 | Hydroxycalcidiol measurement | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000334 | inverse_isa | C3537249 | 24,25-Dihydroxyvitamin D 3 | D Vitamin | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | A family of lipo-soluble steroids important to the absorption, metabolism, and function of calcium and phosphorus and the growth and development of bone and tooth enamel. Found naturally in animal tissues, cholecalciferol (vitamin D3) is formed in the skin when ultraviolet light activates cholesterol conversion into vitamin D3. Ultraviolet irradiation of ergosterol (plant vitamin D) forms ergocalciferol (vitamin D2). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C941" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C941" NCI Thesaurus) |
C0000334 | subset_includes_concept | C1880653 | 24,25-Dihydroxyvitamin D 3 | FDA Established Names and Unique Ingredient Identifier Codes Terminology | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | The terminology that includes terms pertaining to FDA/USP Substance Registration System (SRS), which is to support health information technology initiatives by generating unique ingredient identifiers (UNIIs) for substances in drugs, biologics, foods, and devices. |
C0000334 | subset_includes_concept | C3899741 | 24,25-Dihydroxyvitamin D 3 | CTRP Terminology | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | Terminology that is used to support NCI's Clinical Trials Reporting Program (CTRP), a database that captures the required reporting data for all NCI-sponsored clinical trials. |
C0000334 | subset_includes_concept | C4684827 | 24,25-Dihydroxyvitamin D 3 | CTRP Biomarker Terminology | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | A set of terms that is comprised of the biomarkers referenced in NCI-sponsored clinical trials. |
C0000334 | inverse_isa | C0443767 | 24,25-Dihydroxyvitamin D 3 | Vitamin D3 metabolite | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000334 | inverse_isa | C1520059 | 24,25-Dihydroxyvitamin D 3 | Vitamin D Analog | A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL. | null |
C0000340 | associated_with | C0268689 | Calcidiol 1-Monooxygenase | Vitamin D-dependent rickets, type 1 | A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). | A rare, genetic disorder of vitamin D metabolism characterized by severe hypocalcemia leading to osteomalacia and rachitic bone deformations, and moderate hypophosphatemia. |
C0000340 | mapped_to | C1522417 | Calcidiol 1-Monooxygenase | CYP27B1 protein, human | A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (508 aa, ~57 kDa) is encoded by the human CYP27B1 gene. This protein is involved in vitamin D metabolism. |
C0000340 | inverse_isa | C0020364 | Calcidiol 1-Monooxygenase | Mixed Function Oxygenases | A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol). | Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation. |
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