query stringlengths 1 6.15k | document stringlengths 1 333k | dataset stringclasses 28 values |
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are bagels vegan dunkin donuts? | 1. Bagels. ... Vegans, rejoice, because Dunkin' Donuts offers several (yes, several) bagels that are vegan-friendly. Flavors include Cinnamon Raisin, Everything, Garlic, Onion, Plain, Poppy Seed, Salt, and Sesame. | gooaq |
when did the first sobp mutation occur in humans | the dermal papillae of hair follicles. In human, an autosomal recessive mutation causes severe mental retardation with anterior maxillary protrusion and strabismus, named MRAMS syndrome (OMIM #613671). Homozygosity-mapping linked MRAMS syndrome to a 9.8 Mbp region on 6q21. Evaluation of candidate genes within this interval identified a homozygous missense mutation in "SOBP" in patients with MARMS syndrome. The mutation truncates the SOBP protein near the carboxy-terminus (p.R661X). In the mouse, two spontaneous recessive autosomal mutations occurred independently at The Jackson Laboratory that were named jackson circler ("jc"). The first mutation occurred in 1970 on the C57BL/6J background, named C57BL/6J-"jc" and | paq |
Lee County woman sentenced to prison for embezzling vulnerable adult | LEE COUNTY, Miss. (WJTV) — A Lee County woman is sentenced to prison for embezzlement and ordered to pay $162,000 in restitution to the victim.
A judge sentenced 66-year-old Dorothy Whaley to 10 years in prison with five of those years suspended, Attorney General Jim Hood said.
She was convicted on one count of embezzlement.
Whaley must pay $1,000 in fines, $200 for investigative costs and $100 to the Mississippi Crime Victim Compensation Fund. Additionally, she must pay full restitution of $162,000 to the victim.
The defendant and her daughter were arrested on February 13, 2014.
In addition to the embezzlement count, Whaley was charged with exploitation of a vulnerable person.
At the time of the crime, Whaley was serving as a caretaker for a woman with dementia.
An investigation revealed that Whaley and her daughter exploited the victim in taking approximately $162,000 from the victim’s checking accounts and retirement savings and converting them to their own use.
The AG’s office said Whaley also quitclaimed two of the victim’s properties to herself. The value of the properties exceeded $200,000.
In August 2016, April Whaley. Dorothy Whaley’s daughter entered a guilty plea and was sentenced to serve one year in prison and ordered to pay $33,000 in restitution following her conviction of exploitation of a vulnerable person.
“It is truly tragic when a caretaker, like a parasite, preys on his or her vulnerable charge, and I thank Judge Gardner for sentencing this defendant to pay full restitution, and time to serve in prison,” Attorney General Jim Hood said. “I encourage family members and friends to thoroughly check the employment background and call the references of anyone hired to provide caregiving services to a vulnerable person. If you suspect that a neighbor, friend or loved one is being preyed upon by a caregiver or service provider, call my office. | ccnews |
Computes a distances to a vertex p | function geodesic_distance(cells, positions, p, max_distance, tolerance, stars) {
if(typeof(max_distance) === "undefined") {
max_distance = Number.POSITIVE_INFINITY
}
if(typeof(tolerance) === "undefined") {
tolerance = 1e-4
}
if(typeof(dual) === "undefined") {
stars = top.dual(cells, positions.length)
}
//First, run Dijkstra's algorithm to get an initial bound on the distance from each vertex
// to the base point just using edge lengths
var distances = dijkstra(p, stars, cells, positions, max_distance);
//Then refine distances to acceptable threshold
refine_distances(p, distances, positions, stars, cells, max_distance, tolerance);
return distances;
} | codesearch |
Evaluation Study on Composite Hull Structure Subjected to Slamming Loads | Local slamming impact of sandwich composite hulls | s2orc_citation_titles |
A 33-year-old convicted sex offender was arrested Tuesday afternoon on suspicion of raping two women in Vista and kidnapping one of them. | Sex offender arrested on suspicion of raping two women in Vista | sentence_compression |
Help with Ork looting rule. | I know the basics of this rule as in you can get looted rhino's, vindicator's ect but can you loot eldar and necron vehicles. Also my friend said you can loot dreadgnoughs, Helldrake's, Hellbruts. Can you actually do that? | reddit_title_body |
Good variety and layout | This cookbook has a good layout and the pointsPlus values are easy to find. All the recipes are decently low in pointsPlus. I've tried about a half dozen recipes and they were flavorful. The hard cover and three-ring binder enable it to stand by itself without the need for a recipe holder, but it isn't too large to fit on mine. | amazon_reviews |
//DestPort -- returns the appropriate destination port | func (p *Packet) DestPort() uint16 {
if p.ipHdr.ipProto == IPProtocolTCP {
return p.tcpHdr.destinationPort
}
return p.udpHdr.destinationPort
} | codesearch |
Steam gift acceptance failure? | My Dad just gifted me Skyrim. When I go to my e-mail to redeem my gift it says: Gift acceptance failure and that my "guest passy" has already been redeemed. My problem is that my Dad never purchased a "guest pass" and that the game is now not showing up in my games list. I contacted steam with no response of course. Has this happened to anyone else before? Thanks!
-YSIIR | reddit_title_body |
Wider-community Segregation and the Effect of Neighbourhood Ethnic Diversity on Social Capital: An Investigation into Intra-Neighbourhood Trust in Great Britain and London | “Hunkering Down or Hunkering Away?” The Effect of Community Ethnic Diversity on Residents' Social Networks | s2orc_citation_titles |
What is the statute of limitations on felony utility fraud in indiana? | What is the statue of limitations for a class d felony in the state of indiana? | wikianswers |
Roma, 15:04 - CALCIO, ROMA: NESSUNA LESIONE PER TOTTI | Nessuna lesione per Francesco Totti. Il capitano della Roma, uscito ieri per infortunio durante la s... | agnews |
and is of excellent quality in both the cotton and the workmanship | It's gorgeous, feels gorgeous, and is of excellent quality in both the cotton and the workmanship. | amazon_reviews |
What term does AMD use to describe the processor technology that uses a 64-bit instruction set with a 32-bit internal core processing? | What term does AMD use to describe the processor technology that uses a 64-bit instruction set with set with 32-bit internal core processing? | wikianswers |
Calculates digest and returns the value as a hex string.
@param is input stream
@param digest digest algorithm
@return digest as a hex string
@throws IOException On error reading from the stream | public static String dgstHex(InputStream is, Digest digest) throws IOException {
checkNotNull(is);
byte[] dgstBytes = dgst(is, digest);
return BaseEncoding.base16().encode(dgstBytes);
} | codesearch |
when was do n 't sit down cause i've loved your chair released | video for the single premiered on 14 April 2011 on YouTube. "The Blond-O-Sonic Shimmer Trap" also appears as the Japanese bonus track on "Suck It and See". In an interview, Alex Turner said "I.D.S.T" stands for "If Destroyed Still True" and is considered the second part of "Brick by Brick". "Don't Sit Down 'Cause I've Moved Your Chair" charted at number 28 in the UK Singles Chart on downloads alone, for the week of 23 April. It spent one week in the top 40, dropping to number 43 the following week. It spent six weeks within the top 100 before | paq |
J. TERENCE THOMPSON 2820-1B storage boxes | Storage boxes that I have purchased work but the J. TERENCE THOMPSON 2820-1B works the best. I plan to purchase more. Lots of room, nice closures and stack very nicely. | amazon_reviews |
Prosocial apathy for helping others when effort is required | Lockwood et al. use a real-effort task and computational modelling to examine how individuals choose to expend effort when rewards accrue to themselves versus others. They find that people are less motivated to work for others. | s2orc_title_abstract |
How do you access the light bulbs in the dash of a 1994 chevy s10 blazer? | Dash lights on 1994 s-10 blazer s-10 wont come on? | wikianswers |
Is it dangerous to have a shower after eating? | Is it okay to take a shower after eating? | wikianswers |
What is the weight of a Transit 150 LWB? | How much does a ford transit 100 LWB weight in ton? | wikianswers |
where does glimepiride metabolize to m | yet it is unknown if this results in clinically meaningful effect on blood glucose. M is further metabolized to M metabolite by cytosolic enzymes. M is pharmacologically inactive. Excretion in the urine is about 65%, and the remainder is excreted in the feces. Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors. Not all secondary sufonylureas have the same risk of hypoglycemia. Glibenclamide (glyburide) is associated with an incidence of hypoglycemia of up to 20–30%, compared to | paq |
Prenatal exposure to a non-steroidal anti-inflammatory drug or saline solution impairs sciatic nerve morphology: a stereological and histological study | The effect of diclofenac sodium on neural tube development in the early stage of chick embryos | s2orc_citation_titles |
Does diddy dirty money sings im coming home with sky gray? | Is coming home diddy dirty money a christian song? | wikianswers |
ON THE DUSTIEST LOCATIONS ON MARS FROM OBSERVATIONS | Eight-year Climatology of Dust Optical Depth on Mars | s2orc_citation_titles |
Advances in building energy simulation in the U.K. - The science and engineering research council's programme | EFFECTIVE USE OF BUILDING ENERGY SIMULATION FOR ENHANCING BUILDING ENERGY CODES | s2orc_citation_titles |
Biomechanical explanations are fundamental to studies of functional dental morphology. Until recently foods were not classified in mechanical categories amenable to a rigorous examination of the fundamental physical relationship between teeth and foods. Fruit, insect and leaf categories, although descriptive, are mechanically heterogeneous. The diets of five Malagasy lemur taxa were described in terms of two mechanical properties, hardness and shear strength, in an earlier study (Yamashita, 1996b). In the present study, correlations between these two physical food properties and second molar tooth features of two lemur families are examined. Several relationships are hypothesized: 1) crest length is expected to be positively correlated with food shear strength; 2) the radius of curvature (r) of cusps is expected to be positively correlated with food hardness; and 3) basin area should increase relative to cusp radius as food hardness increases, and cusp-to-basin ratios should decrease with increasing food hardness. Two additional hypotheses address the debate concerning the relative influences of the most frequently eaten foods versus the most stressful foods in determining tooth form. The results of the predicted relationships are equivocal. 1) Crest length is negatively instead of positively correlated with strong foods. Crest lengths are correlated with quantities of leaf consumption, which are related to leaf shape more than to material composition. 2) As expected, r is positively correlated with food hardness and negatively with shear strength, but this applies to upper molar cusps only. Lower molar cusps complicate simple generalizations of relationships. 3) Hard foods are correlated with a tight fit of occluding cusps and basins instead of the expected loose fit. The most stressful foods eaten (hardest and strongest) have higher correlations with tooth features than the most frequently eaten foods. Several functional complexes can be identified. Hard food items are correlated with short cusps in lemurids, tight occlusal fit, small trigon and large talonid areas, and deep, acute basins. Large, shallow trigons, shallow, unrestricted talonids, and large upper molar basins are indicative of a diet of strong foods. These results demonstrate that some variation in tooth features is explicable with reference to mechanical properties of diet, although the relationships are complex. Am J Phys Anthropol 106:169–188, 1998. © 1998 Wiley-Liss, Inc. | The ring-tailed lemurs at Beza Mahafaly Special Reserve, Madagascar, exhibit a high frequency of severe wear and antemortem tooth loss. As part of a long-term study, we collected dental data on 83 living adult ring-tailed lemurs during 2003 and 2004. Among these individuals, 192 teeth were scored as absent. The most frequently missing tooth position is M1 (24%). As M1 is the first tooth to erupt, its high frequency of absence (primarily a result of wear) is not remarkable. However, the remaining pattern of tooth loss does not correlate with the sequence of eruption. We suggest that this pattern is a function of 1) feeding ecology, as hard, tough tamarind fruit is a key fallback food of ring-tailed lemurs living in gallery forests; 2) food processing, as tamarind fruit is primarily processed in the P3-M1 region of the mouth; and 3) tooth structure, as ring-tailed lemurs possess thin dental enamel. The incongruity between thin enamel and use of a hard, tough fallback food suggests that ring-tailed lemurs living in riverine gallery forests may rely on resources not used in the past. When comparing dental health in the same individuals (n=50) between 2003 and 2004, we found that individual tooth loss can show a rapid increase over the span of one year, increasing by as much as 20%. Despite this rapid loss, individuals are able to survive, sometimes benefiting from unintentional assistance from conspecifics, from which partially processed tamarind fruit is obtained. Although less frequent in this population, these longitudinal data also illustrate that ring-tailed lemurs lose teeth due to damage and disease, similar to other nonhuman primates. The relationship between tooth loss, feeding ecology, dental structure, and individual life history in this population has implications for interpreting behavior based on tooth loss in the hominid fossil record. | s2orc_abstract_citation |
Looking for advice on first treadmill purchase | I'm looking at treadmills around $400-$500 dollars. I know that they don't get really good until the 1k range, but I just don't have that kind of money, and I really want a treadmill to run on daily, I think it would help me have the motivation to lose weight.
Anyway, I've been looking for one with good cushioning, power incline, decline would be nice, and those grabby bars to measure your heart rate.
I've been looking online but I don't know which ones are good, or which ones will just break or burn out quickly. I've already checked Craigslist, but there are none close to me, and no stores selling them close to me either, so I'm looking for one I can have shipped.
I'd really appreciate any help, thanks. | reddit_title_body |
how can electromagnetic waves travel through empty space? | Electromagnetic waves are waves that can travel through matter or through empty space. ... However, when light travels in matter, it interacts with the atoms and molecules in the material and slows down. As a result, light travels fastest in empty space, and travels slowest in solids. | gooaq |
We have the grade 8 math book, copyright 2015 ... | We have the grade 8 math book, copyright 2015, and have found many wrong answers in the answer key, and a few problems that are set up incorrectly. Its very frustrating. I would be returning it if my son hadn't already written in it. | amazon_reviews |
Super chic dog carrier and well built | Super chic dog carrier and well built, too. But way too wide to carry on the shoulder comfortably. The picture is a side-by-side comparison to the MG Collection I have. Will buy it if they made a slimmer one. | amazon_reviews |
Grade Your Team's BCS Era Bowl History | The Ohio State University BCS Bowl Era History:
13 Bowl Appearances, 2 Bowls Missed
National Titles- 1
7 Bowls Won, 6 Bowls Lost
Average Margin of Victory- 11.14
Average Margin of Defeat- 11.83
Finished Ranked 10 Times, Unranked 5 Times
Average BCS Rank of Opp.(When Ranked)- 8.82
Average BCS Rank of OSU (When Ranked)- 5.70
Grade: A-
Ohio State was overall very good and very consistent but not given an A due to large margin of defeat. | reddit_title_body |
how many nuns are missing in the sands of time | The Sands of Time (Sheldon novel) priest, but they manage to subdue him before he rapes Graciella. They change out of their convent clothes to seem inconspicuous while travelling. However, they run into Jaime and his men, along with Jaime's girlfriend Amparo. Afraid that the sisters will give away their location, they decide to take them to their hideout. Colonel Acoca has figured out that four of the nuns are missing and is convinced that Jaime Miró escaped before the soldiers got there. The Prime Minister doubts that he was there in the first place and believes that Acoca is starting to get out of control, | paq |
What does increased mean in math? | How do you increase in maths? | wikianswers |
What kind of conjunction should you use to introduce an adverbal clause? | What word can be used to introduce an adverb clause? | wikianswers |
I love this pedometer | I love this pedometer. It is lightweight and easy to set up. The clip holds the device to the belt well. Money well spent. | amazon_reviews |
What part of a bobsled vehicle can they use after crossing finished line? | What part of their vehicles are bobsledders only allowed to use after crossing the finish line? | wikianswers |
what is the motto of the worshipful company of skinners | Worshipful Company of Skinners The Worshipful Company of Skinners (known as The Skinners' Company) is one of the Livery Companies of the City of London. It was originally an association of those engaged in the trade of skins and furs. It was granted Royal Charter in 1327. The Company's motto is "To God Only Be All Glory". Under an order issued by the Lord Mayor of the City of London on 10 April 1484 (known as the Billesdon Award), the Company ranks in sixth or seventh place (making it one of the "Great Twelve City Livery Companies") in the order | paq |
Double periodic composite right/left handed substrate integrated waveguide | Broadband leaky-wave antenna based on composite right/left handed substrate integrated waveguide | s2orc_citation_titles |
Who was frederick douglass's wife? | Who was fredderick douglass's first wife? | wikianswers |
Compact handle fits hand well to stabilize camera | Compact handle fits hand well to stabilize camera. Price point ~$6 is half of stateside version. Screwed smoothly into camera. I am buying a second one to keep in car. | amazon_reviews |
Partial Oxidation of Ethylene Over Silver Catalyst Supported on Mesoporous Materials | IR Study of the Secondary Reaction of Ethylene Oxide over Silver Catalyst Supported on Mesoporous Material | s2orc_citation_titles |
Reports of woman leaping into East River in Williamsburg at 7.30pm Friday .
She jumped from a floating pier as a ferry approached, police said .
NYPD harbor patrol struggled to get her out because of floating ice .
Was in the water 20 minutes and removed in extremely critical condition .
Police said a person would likely die in less than four minutes in such conditions . | A woman has died in hospital after being pulled from New York's icy East River in a critical condition on Friday night. Police believe the woman - who is yet to be identified - jumped from a floating ferry pier in Brooklyn. The incident occurred at Kent Avenue near N. 5th Street in Williamsburg at about 7.30pm . According to The New York Daily News, a ferry was approaching the pier at the time the woman jumped. Scroll down for video . Scene: The NYPD, FDNY, and Coast Guard rushed to a pier in Williamsburg on Friday night after a woman leaped into freezing East River as a ferry approached about 7.30pm. Here they work to rescuscitate the woman after pulling her from the icy water . Rescue: The NYPD harbor patrol struggled to get the woman as quickly as the could have, with the amount of ice floating in the East River impeding their rescue effort. The NYPD tweeted this photo from the scene . FDNY Battalion Chief Paul Tague told WABC New York the ferry captain saw the woman jump. She was carried by the tide about three blocks south of the dock, the paper reported. Officials at the scene said the water temperature was so cold that it would kill a person after about four minutes. The woman was believed to have been in the water for about 20 minutes. The NYPD, FDNY, and Coast Guard all responded to the area near Brooklyn Bridge. Divers in protective gear entered the water. The rescue effort took longer than usual because of the amount of floating ice in the East River from the Arctic blast, police said. The woman was pulled out in an extremely critical condition. Medics at the scene administered CPR as they rushed her to Woodhull Hospital. She was pronounced dead in hospital. A diver that went into the water was also taken to hospital, but is fine. Frozen: Officials said the temperature of New York's East River is so freezing, it would kill you in less than four minutes. The woman was believed to have been in the water for 20 minutes before being pulled out . The woman's name has not been released, pending notification of next of kin. Earlier Friday a man's body was also pulled from the East River. The body was found near Murray Hills and police said it was badly decomposed. The man was wearing black pants and had no identification on him, according to The New York Post. Police are trying to establish whether there was foul play involved or if the death was accidental. February has officially been the coldest month in New York for 81 years. The average temperature in the Big Apple over the last four weeks has been 24F - 11 degrees below normal. New York joins other metropolitan areas such as Chicago and Pittsburgh, which have also experienced their most frigid February in decades. Duties continue: The tug Arabian Sea pushes a barge through the icy waters of the Hudson River on Friday, near Rhinecliff, in Upstate New York. With the prolonged cold winter weather, the Coast Guard has been busy clearing shipping lanes . | cnn |
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes | Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors | s2orc_citation_titles |
what good is this without the socket | Insane. Sell this product without the phone mount socket??? Sold separately I find out now....what good is this without the socket? Why would it need to be purchased separately. Again...insane. | amazon_reviews |
Technical Note Uptake of endocrine disruptor bisphenol-A onto sulphuric acid activated carbon developed from biomass: Equilibrium and kinetic studies | *Corresponding author Email: cnamasi@gmail.com Activated carbon prepared from coir pith, an agricultural solid waste by product has been used for adsorption of Bisphenol-A from aqueous solution. The sulphuric acid activated coir pith carbon was characterized by Scanning Electron Microscope and Fourier Transform Infrared Spectroscopy. Parameters such as agitation time, initial concentration, adsorbent dose and pH were studied. Equilibrium adsorption data followed both Langmuir and Freundlich isotherms. Adsorption followed second order rate kinetics. The adsorption capacity calculated from the Langmuir isotherm was 55 -1 mg g at an initial pH 2 at 35 °C for the 250-500 μm particle size carbon. . | s2orc_title_abstract |
A large region charaterized by a specific kind of climate and certain kinds of plant and animal communities? | A large region charaterized by a spcific type of climate and certain types of plant and animal communities? | wikianswers |
Knowledge of patterns of genetic diversity in populations of threatened species is vital for their effective conservation. Rosalia longicorn (Rosalia alpina) is an endangered and strictly protected beetle. Despite a marked decline in part of its range, the beetle has recently expanded to the lowlands of Central Europe. To facilitate a better understanding of the species' biology, recent expansion and more effective conservation measures, we investigated patterns of genetic structure among 32 populations across Central and South-east Europe. Eight microsatellite loci and a partial mitochondrial gene (cytochrome c oxidase subunit I) were used as markers. Both markers showed a significant decline in genetic diversity with latitude, suggesting a glacial refugium in north-western Greece. The cluster analysis of the nuclear marker indicated the existence of two genetically distinct lineages meeting near the border between the Western and Eastern Carpathians. By contrast, one widespread mtDNA haplotype was dominant in most populations, leading to the assumption that a rapid expansion of a single lineage occurred across the study area. The genetic differentiation among populations from the north-western part of the study area was, however, surprisingly low. They lacked any substructure and isolation-by-distance on a scale of up to 600 km. This result suggests a strong dispersal capacity of the species, as well as a lack of migration barriers throughout the study area. That the lowland populations are closely related to those from the nearby mountains indicates repeated colonization of the lowlands. Our results further suggest that R. alpina mostly lives in large, open populations. Large-scale conservation measures need to be applied to allow for its continued existence. | A paucity of genetic information and the drastic decline in population size of the beetle Cerambyx cerdo has made this species a high priority for research and conservation management. The state-listed beetle, a saproxylic insect associated with oaks, has a discontinuous range, with larger and more connected populations in southern Europe and small and isolated populations in the continent’s central and northern parts. Here, we used seven microsatellite loci and one DNA fragment of the mitochondrial gene COI to examine the population structure, genetic diversity, and contemporary gene flow between two Polish populations of the beetle. A population viability analysis summarizing collected genetic data as well as field records and species-specific information was performed to investigate the probability of the populations’ persistence over 20 years under different simulation scenarios. Genetic drift due to spatial isolation and bottleneck(s) is probably a major evolutionary force responsible for a low number of haplotypes and lower gene diversity in these populations as compared to the neighboring Czech populations. Despite a large geographic distance between the Polish populations, genetic differentiation between them was low, which could reflect shared ancestral polymorphism and stochasticity of retained alleles rather than the homogenizing effect of gene flow. Differences among probabilities of extinction over 20 years were detected between populations, and, in the worst-case scenarios, one population will disappear within four generations. Conservation efforts must focus on supplementation, habitat restoration, and post-release monitoring. The results of our study provided information that can be incorporated into future management actions to aid in the conservation of the beetle. | s2orc_abstract_citation |
Plasmonic structure integrated single-photon detectors for absorptance and polarization contrast maximization | Plasmonic Structure Integrated Single-Photon Detector Configurations to Improve Absorptance and Polarization Contrast | s2orc_citation_titles |
Will smith fan mailing address? | What is Will Smith's fanclub address? | wikianswers |
You are going to a party.\nwhat will you wear? (there'll be hot guys at the party)\nwould you RATHER take option A or option B (you cannot choose neither)\n\nOption A. You wear jeans with NO undies, white shirt, no bra, and deodorant\nOption B. You wear short-shorts with thongs, a tight mid-drift black shirt, a bra, but no deodorant\n\nCHOOSE AN OPTION-- EXPLAIN WHY | Option A\n\nGo without a bra as much as you can before you have kids and can't anymore.\n\nALL THE TIME! \n\nAnd panties are never comfortable. | yahoo_qa |
Scheduling optimization of flexible manufacturing system using cuckoo search-based approach | In the present work, a cuckoo search (CS)-based approach has been developed for scheduling optimization of a flexible manufacturing system by minimizing the penalty cost due to delay in manufacturing and maximizing the machine utilization time. To demonstrate the application of cuckoo search (CS)-based scheme to find the optimum job, the proposed scheme has been applied with slight modification in its Levy flight operator because of the discrete nature of the solution on a standard FMS scheduling problem containing 43 jobs and 16 machines taken from literature. The CS scheme has been implemented using Matlab, and results have been compared with other soft computing-based optimization approaches like genetic algorithm (GA) and particle swarm optimization found in the literature. The results shown by CS-based approach have been found to outperform the results of existing heuristic algorithms such as GA for the given problem. | s2orc_title_abstract |
Is there a role for the midwife in contraception and sexual health services | This paper considers the implications for midwifery practice in relation to the new national strategies for improving services in contraception and sexual health (CASH). The recommended approach is to amalgamate family planning and sexual health services and introduce specialised training for nurses | s2orc_title_abstract |
I transferred to another school and there's this girl that I like but I don't even know her Were not in any classes and all I know is her name but we've never met What can you do? | How do you approach a girl you like and you don't even know her name? | wikianswers |
Arterial Blood Pressure Regulation of Pulpal Blood Flow as Determined by Laser Doppler | Measurement of pulpal blood flow in dogs with nonradioactive colored microspheres. | s2orc_citation_titles |
Patients’ experience of asthma control and clinical guidelines: Perspectives from a qualitative study | Guided asthma self-management or patient self-adjustment? Using patients’ narratives to better understand adherence to asthma treatment | s2orc_citation_titles |
who was the publisher of verdi's opera otello | Otello Otello () is an opera in four acts by Giuseppe Verdi to an Italian libretto by Arrigo Boito, based on Shakespeare's play "Othello". It was Verdi's penultimate opera, and was first performed at the Teatro alla Scala, Milan, on 5 February 1887. With the composer's reluctance to write anything new after the success of "Aida" in 1871 and his retreat into retirement, it took his Milan publisher Giulio Ricordi the next ten years, first to persuade him to write anything, then to encourage the revision of Verdi's 1857 "Simon Boccanegra" by introducing Boito as librettist, and finally to begin | paq |
Lib-Value: Values, Outcomes, and Return on Investment of Academic Libraries, Phase III: ROI of the Syracuse University Library | This study measures the return on investment (ROI) of the Syracuse University library. Faculty and students at Syracuse University were surveyed using contingent valuation methodology to measure their willingness to pay in time and money for the services of the academic library. Their travel time and use of the online library was measured to determine the environmental value of the academic library. The economic and environmental value of the Syracuse University library show an ROI of $4.49 returned to the university for every $1.00 spent each year. | s2orc_title_abstract |
Does Glen Jacobs have any kids? | Has glen jacobs got a kid? | wikianswers |
Non-Americans of Reddit, what do you predict the future of your Country will be? | I would prefer those Americans such as I who are chomping at the bit to answer refrain, for variety's sake. :)
Anyways, What do those of you from other nations believe will be the future of your country? What will change, what will it be like, and what will improve/worsen? | reddit_title_body |
Effect of Gibberellic Acid, Beta-Naphthoxy-Acet1C Acid and 2,4-Dichlorophenoxy-Acetic Acid As Pre-Sowing Seed Treatment on Growth and Yield of Cabbage (Brass1Ca Oleracea Var. Capitata (L.) | The studies were undertaken to find the effect of GA, NOA, and 2,4-D, as pre-sowing seed treatment on the growth and yield of cabbage. None of the treatments affected the height of the plants and the time taken for head formation. The weight of head was maximum at 50 ppm of GA (1.72 kg), followed by 2,4-D at 0.5 ppm(1.43 kg) and 2,4-D at 2.5 ppm (1.40 kg), as against 0.81 kg only under control. | s2orc_title_abstract |
did William Wallace impregnate the Princess of Wales as Braveheart suggests? | With Isabella? She was around 9 years old when Wallace died, so one would hope not. In addition to that I don't believe she had been to England (or for that matter Scotland) until after her marriage (which took place a few years after Wallace died). More than a bit of artistic liberty on the part of Mel Gibson for that one. | eli5 |
Great as fishing reel grease. | This stuff works great for fishing reel grease and the cost is minimal compared to similar (If not identical) products specifically marketed as reel grease. One can will last a LONG time. | amazon_reviews |
how much did rio tinto buy kinross gold | Kinross Gold process plants, two tailings facilities, as well as accompanying infrastructure. On January 31, 2003, Kinross acquired a 49% ownership interest as part of the acquisition of TVX Gold. On December 31, 2004, Kinross acquired the remaining 51% from Rio Tinto for $255 million, and operated the mine as Kinross Brasil Mineração S.A. This mine is the region's largest employer. In 2015, Paracatu produced 477,662 gold equivalent ounces. Red Back Mining Inc. began production in 2008 at the Tasiast mine in Mauritania. In September 2010, Kinross acquired Tasiast by buying all the shares of Red Back. The property includes an open-pit | paq |
are the rolled chicken tacos good? | Overall, Taco Bell's Rolled Chicken Tacos were really good, offering a tasty blend of crunchy and soft, plus a good variety of dipping sauces to suit your tastes (unless you want something with a serious kick as the spiciest sauce, the Spicy Ranch, is still fairly mild). | gooaq |
3 rivers found in New York? | What is some of New York's major rivers? | wikianswers |
Good book, but once again | Good book,but once again,it reads as if Sephardic Jews did not exist!---still,it is a fun and useful book. | amazon_reviews |
Doyou find loyalty and treason and disobedience and nationalism in 'Antigone'? | Do you find loyalty and disobedience and treason and nationalism in 'Antigone'? | wikianswers |
Why did stone cold leaves WWE? | Why did stone cold leave WWE in 2002? | wikianswers |
(NSFW) What thing do you do regularly that you do not want your partner to find out about? | What habit do you regularly indulge in, that you have (somehow) managed to keep a secret from your partner. Either you're embarrassed by it or you think that they wouldn't tolerate it? | reddit_title_body |
who is the executive director of open society foundation of south africa | Open Society Foundation for South Africa The Open Society Foundation for South Africa (OSF-SA) is a South African non-profit grant-making organisation that supports the civil society sector. Its mission is to "promote the values, institutions and practices of an open, non-racial and non-sexist, democratic civil society." The foundation was established by George Soros in 1993, just prior to the dismatling of apartheid and South Africa's transition to democracy. OSF-SA's Executive Director is Fatima Hassan who is a human rights lawyer and social justice activist. Before joining OSF-SA she was a lawyer for the Aids Law Project where she frequently represented | paq |
Why do people weigh more on earth then the moon? | WHy do you weigh more on the moon than you do on Earth? | wikianswers |
Free surface flow impacting on an elastic structure: Experiment versus numerical simulation | Abstract The purpose of this study is to investigate the phenomenon of free surface flow impacting on elastic structures, which is a research topic of great interest in ship and ocean engineering. A series of quasi two-dimensional experiments on dam-break with an elastic plate are conducted. The main features of free surface flow impacting on elastic structures including large impacting force, structural vibration, violent free surface flow, are investigated. The coupled FDM–FEM method developed by the authors is applied for numerical simulation of such dam-break problem. Extensive analysis and discussion based on the comparisons between experimental data and numerical results are made and presented in this paper. | s2orc_title_abstract |
Must read for both entrepreneurs and Fortune CEOS' | As a serial entrepreneur ( Fortune 1997) and mentor to entrepreneurs I highly recommend this outstanding book. This isn't Mui first book and certainly hope it's not his last. It should b required reading by those CEOs' that can not understand why startups are merger targets by corporate America.
Entrepreneurs must read this in order to understand the new rules. Jerry R Mitchell | amazon_reviews |
I have a little theory for Star Wars: Battlefront 3 | Now this isn't some huge complicated theory, and this is why I have even more hope that this could actually happen. Well as we all know Disney is releasing "Star Wars 7". This would be THE perfect time for a new Star Wars Battlefront game to come out. The new consoles should have been out for about 2 years at that point. So there would be plenty of time for the dev to get used to the new consoles and create a really awesome game to go along with the new movie. It would feature all of the old classic battles as well as some new ones from the new film. I think it'd be really really cool. | reddit_title_body |
How Pateley Bridge's community spirit helped secure a spot among the Sunday Times' best places to live | Residents in Pateley Bridge have been left ecstatic following news of the town’s listing in the Sunday Times’ Best Places to Live Guide for 2018.
For the second consecutive year the town has received the award, with recognition for it’s thriving High Street and draw of the Nidderdale AONB in this weekend’s edition of the national paper.
While these factors are important the community of Pateley Bridge has given itself a strong foundation to possibly to earn greater accolades in future listings, says Chairman of the Nidderdale Chamber of Trade, Keith Tordoff.
He said: “I am simply ecstatic because it is the second year in a row Pateley Bridge has been listed, many from last year’s were not featured.
“We would have been pleased to see us come first for overall in the north but this is an excellent result.”
He added:“It is our community which makes us so strong, we have a good foundation to work from. People come to the area and continue to add to this, whether that is caraveners coming over for the summer, going to our churches or attending events, everyone is always contributing.
“It is why people want to come and live here, for that community, independent businesses and not massive chains, facilities like our bus service, excellent schools and churches that all work together.”
It is a sentiment shared by the Mayor of Pateley Bridge, Chris Hawksworth, who highlighted the efforts of the town’s volunteers in earning it’s place in the listing.
He said: “ I think the reason we have done so well is because everyone pulls together, and that is partly due to all of our volunteer groups. The museum was only just recognised last year with the Queens Award for their work.
“It is things like this are indicative of the innovative stuff that everyone has been doing here.”
He added: “Everyone knows everyone here, it is a manageable size, while York has the added advantage of improving train links , we are within the tide of Leeds and Bradford but also have the Nidderdale AONB. “
The town has not rested on its laurels since last year, Mr Tordoff added, pointing to the silver gilt Pateley Bridge won in the Yorkshire in Bloom competition and the launch of a Community Heroes Award.
Alongside this the return of 1940s Weekend will see a particularly special display of community spirit, with three churches coming together for the marriage of Nidderdale residents, Chris Stark, 81, and Olive Moyses.
The ceremony will take place at Pateley Bridge Methodist Church, with Reverend Mike Poole conducting the ceremony with assistance from Reverand Darryl Hall of St Cuthbert's Church and Father Michael Walsh of Our Lady Immaculate Roman Catholic Church.
He said: “This is why people keep on coming back, 12 months on they are asking what we have done and we can say we have entered a competition like Yorkshire in Bloom, and our churches are working together like this.” | ccnews |
A new species of Neorhadinorhynchus (Acanthocephala: Cavisomidae) from Platax teira (Ephippidae) from Iraqi marine waters | Morphological and molecular study of Neorhadinorhynchus nudus (Harada, 1938) (Acanthocephala: Cavisomidae) from Auxis thazard Lacepede (Perciformes: Scombridae) in the South China Sea | s2orc_citation_titles |
Aelfric and the Early Medieval Homiliary | Authority and Intertextuality in the Works of Ælfric | s2orc_citation_titles |
how many bars were there on the xerox alto keyboard | Xerox Alto among Alto users, the chord keyset never became popular. In the early mice, the buttons were three narrow bars, arranged top to bottom rather than side to side; they were named after their colors in the documentation. The motion was sensed by two wheels perpendicular to each other. These were soon replaced with a ball-type mouse, which was invented by Ronald E. Rider and developed by Bill English. These were photo-mechanical mice, first using white light, and then infrared (IR), to count the rotations of wheels inside the mouse. The keyboard is interesting in that each key is represented as | paq |
What is adobe reader 9.3? | For what you need adobe reader? | wikianswers |
Call for alcohol advert watershed | TV adverts for alcoholic drinks should be banned before the nine o'clock watershed, a campaign group says. | agnews |
Is a little amount of sleep better than no sleep at all? | I have searched around and found no conclusive evidence to support either being better than the other...
Right now I am torn between getting 3 hours sleep or none at all. It isn't a regular occurance it would just be for the one night. Which would be healthier and which would make me feel more awake? | reddit_title_body |
Former X Factor judge was due to hear verdict on assault charge today .
Denies leaving writer Savvas Morgan with swollen eye at V-Festival, Essex .
Following legal argument, judge adjourned case to call more witnesses .
Will not resume until at least July 2, Tulisa said 'this is my life on the line' | By . Mia De Graaf . Wait: Former X Factor judge Tulisa Contostavlos was due to hear the verdict today on her assault charge but will now have to wait until at least July 2 . Former X Factor judge Tulisa Contostavlos must wait more than a month to discover the outcome of her trial over claims she assaulted a celebrity blogger. The singer arrived at court today to hear the verdict on claims she left writer Savvas Morgan with a swollen eye. But following a legal argument, District Judge Angus adjourned the case so that further witnesses can be called. One of the outstanding issues surrounds the existence of a 'lost' photograph of Mr Morgan’s injuries allegedly inflicted by the ex-N-Dubz singer at V-Festival in Essex last August. There will now be no verdict until at least July 2 when the case will resume. Judge Hamilton said: 'I am anxious this does not go on any longer than necessary.' During the trial, Contostavlos, who pleaded not guilty to assault, said she was disappointed 'a playground slanging match' had reached court and was keen for it to be resolved adding: 'This is my life on the line.' She has claimed she did not attack him and has been the . victim of a vendetta, saying Mr Morgan had a 'strange obsession' with . her. The star is on trial at Chelmsford . Magistrates’ Court with her assistant, Gareth Varey, who is accused of . threatening behaviour, which he also denies. Earlier today Contostavlos’ tour manager, Drew Lyall, said he had put an arm around her after witnessing the aftermath of the incident which happened in a backstage area. Mr Lyall, who told the court he had assisted Contostavlos on hundreds of occasions, added: 'She was very upset and briefly mentioned it was a guy who had been hounding her or harassing her for a very long period. The singer denies leaving writer Savvas Morgan with a swollen eye at V-Festival in Essex last year . 'She hadn’t mentioned any particular individual before the incident, I had never seen him before. 'She was calm. She was just a little bit upset.' Other . celebrities, including singer and rapper Misha B, Sugababes singer . Mutya Buena, singer Alexandra Burke and rapper Wretch 32, all witnessed . the incident but have not given evidence. Contostavlos . told the court that Mr Morgan had conducted a 'vendetta' against her . since an incident in which she asked security to remove him from a VIP . area at the Whisky Mist nightclub in London’s Mayfair. She also outlined her suspicions that Mr Morgan was involved in the release of a sex tape of her online. Tulisa arriving at Chelmsford Magistrate's Court before a legal dispute led to the case being adjourned . But she claimed she had no grudge against him, saying: 'He was one of many.' Mr Morgan told the court that Contostavlos raised her fists in the air and was swinging her arms in a backstage area at the festival. 'Everyone was jumping around trying to get at me, there was a lot going on,' he said. Prosecutor Matthew McNiff said the incident happened at 12.30am on August 18 as Mr Morgan was about to leave. He said Contostavlos accused Mr Morgan of stalking her, and swore at him. Contostavlos and Varey, 28, both of Royal Drive, Friern Barnet, north London, are both on unconditional bail. Sorry we are not currently accepting comments on this article. | cnn |
Photogeneration of an o-quinone methide from pyridoxine (vitamin B6) in aqueous solution | 1 PHOTOCHEMICAL GENERATION AND CHARACTERIZATION OF QUINONE METHIDES | s2orc_citation_titles |
What is the minimum number of presidental elctors from any state? | The minimum number of presidential electors in each state? | wikianswers |
I need to copy all jpg files from a directory in linux I want to copy all the jpg files from a directory to another directory. How do i make to copy all files finishing in jpg? | Copying only JPG from a directory structure to another location Linux I wish to recursively go through the folders of a directory structure and copy any .jpg I find into another directory. I think I had the wrong idea with: cp -R photos/*.jpg /cpjpg How can I do this from the command line in Ubuntu? | stackexchange_title_body |
How can I be sure that I have had an orgasm? | I am a 21 year old female who has been with my boyfriend, whom I love very much, for two years. Our sex life is good, we both enjoy sex, initiate it and are comfortable communicating about it. However, I am not 100% sure that I have ever orgasmed.
When we have sex, (particularly when he stimulates me with his hand) it feels incredibly good, to the point that I often feel like I need to stop him because I cannot handle it (almost like when you are tickled). Everything that you hear on tv and in movies describes this big "release" and says that "you will just know", but I don't experience this one specific feeling or rush. This is what makes me think that I have not orgasmed. However, I have read elsewhere that this is exaggerated and not exactly how it works.
I feel satisfied by sex and on two occasions I have even become so wet that we both think that it was me "squirting", but the fact that my "orgasms" don't match the description that I am used to hearing concerns me a bit and I don't know what to do!
Any advice or info would be greatly appreciated! | reddit_title_body |
A new approach to standardizing the dean's letter. | A follow-up study of the characteristics of dean's letters. | s2orc_citation_titles |
Why have the tension between india and pakistan become a global concern? | Why is the tension between india and pakistan become a global concern? | wikianswers |
Another intriguing Lacey Flint thriller | Like the previous three books, this novel focuses mainly on the protagonist Lacey Flint. What I liked about this book in the series was that it also shifted focus onto some of the other primary characters and gave us a little more insight into them. If you have enjoyed the first three books, you will like this one as well. A good old fashioned thriller with plenty of plot twists and turns. | amazon_reviews |
How old do you have to be to work at chucky chesse in alaska? | How old do you have to be to work at mcdonalds in anchorage alaska? | wikianswers |
As turbine operating temperatures continue to rise, there is the ever present problem of cooling airfoil components. To accomplish this, cooling methods have morphed into a complex array of specialized internal and external schemes. A majority of cooling methods involve routing cool air from the compressor, through internal cooling channels and out through various film cooling holes around the blade surface. These cooling channels serve as a means to transfer heat from the airfoil surfaces to a cooling flow passing through the inside of the vanes and blades. Internal cooling has evolved from simple smooth-walled channels to ones that include various types of turbulators that serve to increase the convective heat transfer coefficient and heat transfer surface area. Turbulators have been studied in detail over the years, and the most preferred cooling designs involve pedestals, ribs, and various surface roughening effects such as dimples. They serve to increase the turbulent mixing of the flow as it passes through the channel, thereby increasing the convective heat transfer coefficient along the wall surfaces. There are many advantages from a cooling perspective to use microchannels to cool components, provided that the pressure to drive the flow through these channels is available. These microchannels approach the level where manufacturing random roughness and tolerances can play a key role in their heat transfer capabilities 1. Average manufacturing roughness in common casting techniques can approach 1‐10 m 2 before polishing or finishing, and this seemly inconsequential inherent roughness can discernibly affect the microchannels’ heat transfer and pressure drop. This paper provides a summary of the findings of an experimental program focused on examining the heat transfer and pressure drop of microchannels. Accurately quantifying these two parameters will enable better prediction of the engine hardware thermal performance and life. The primary objective of this study was to develop a testing procedure capable of evaluating the heat transfer and pressure drop performance of several microchannels over a range of Reynolds numbers. The performance is reported in the form of an overall Nusselt number and friction factor for each manufacturing roughness level. While the results indicate little dependence of heat transfer and pressure drop augmentation upon Reynolds number, the range studied was in the fully turbulent regime in which compressibility effects were not present. | The present study investigates a new class of in-wall mesh cooling techniques intended to produce significant wetted surface area heat transfer enhancement products, hA Awetted , with low to moderate pressure losses. Cooling networks (meshes) are presented using round pins and rounded diamond shaped pins with H/Dp ratios of 0.2 and S/Dp ratios of 1.5, as well as less dense rounded diamond pins of smaller diameter with H/Dp of 0.3 and S/Dp of 2.14. These geometries differ substantially from conventional pin fin arrays in which H/Dp ≥ 1 and S/Dp ratios are typically about 2.5. The objective of mesh cooling is to provide highly effective cooling inside component walls while maintaining very thin outer protective skin thickness. Special attention is paid to the combination of techniques including pin meshes, turbulators, and concavity arrays that can provide multiple design solutions for heat transfer and pressure loss goals. Average channel wetted-area heat transfer capabilities exceeding 3 times that of smooth channels have been demonstrated using actual surface area enhancements of no more than 20%. This cooling capability increase is also realized with a large decrease in channel material solidity, up to 30%, compared to conventional pin fin arrays. Friction factor enhancements in the range of 15 to 25 times that of a smooth channel turbulent flow accompany this performance. This investigation represents the first of its kind to demonstrate feasible in-wall cooling methods that may be realized in practice for investment cast turbine blades.Copyright © 2004 by ASME | s2orc_abstract_citation |
Largest wave recorded on lake? | What is Largest recorded wave in lake ontario? | wikianswers |
In a wild tobacco plant, Nicotiana attenuata, two mitogen-activated protein kinases (MAPKs), salicylic acid-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK), play central roles in modulating herbivory-induced phytohormone and anti-herbivore secondary metabolites. However, the identities of their upstream MAPK kinases (MAPKKs) were elusive. Ectopic overexpression studies in N. benthamiana and N. tabacum suggested that two MAPKKs, MKK1 and MEK2, may activate SIPK and WIPK. The homologues of MKK1 and MEK2 were cloned in N. attenuata (NaMKK1 and NaMEK2) and a virus-induced gene silencing approach was used to knock-down the transcript levels of these MAPKK genes. Plants silenced in NaMKK1 and NaMEK2 were treated with wounding or simulated herbivory by applying the oral secretions of the specialist herbivore Manduca sexta to wounds. MAPK activity assay indicated that after wounding or simulated herbivory NaMKK1 is not required for the phosphorylation of NaSIPK and NaWIPK; in contrast, NaMEK2 and other unknown MAPKKs are important for simulated herbivoryelicited activation of NaSIPK and NaWIPK, and after wounding NaMEK2 probably does not activate NaWIPK but plays a minor role in activating NaSIPK. Consistently, NaMEK2 and certain other MAPKKs, but not NaMKK1, are needed for wounding- and simulated herbivory-elicited accumulation of jasmonic acid (JA), JA–isoleucine, and ethylene. Furthermore, both NaMEK2 and NaMKK1 regulate the levels of trypsin proteinase inhibitors. The findings underscore the complexity of MAPK signalling pathways and highlight the importance of MAPKKs in regulating wounding- and herbivory-induced responses. | Hypersensitive response (HR), a form of programmed cell death, is frequently associated with plant disease resistance. It has been proposed that mitogen-activated protein kinase (MAPK) cascades regulate HR cell death based on pharmacological studies by using kinase inhibitors. However, direct evidence is lacking. Here, we demonstrate that NtMEK2, a MAPK kinase, is upstream of salicylic acid-induced protein kinase (SIPK) and wounding-induced protein kinase (WIPK), two tobacco MAPKs that are activated by various pathogens or pathogen-derived elicitors. Expression of a constitutively active mutant of NtMEK2 induces HR-like cell death in tobacco, which is preceded by the activation of endogenous SIPK and WIPK. In addition, NtMEK2-SIPK/WIPK cascade appears to control the expression of 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) and l-phenylalanine ammonia lyase (PAL), two defense genes encoding key enzymes in the phytoalexin and salicylic acid biosynthesis pathways. These results demonstrate that a plant MAPK cascade controls multiple defense responses against pathogen invasion. | s2orc_abstract_citation |
@param string $region
@param mixed $credential
@return CloudWatchLogsClient|null | public function getCloudWatchLogs($region, $credential)
{
if (!$config = $this->getConfigWithCredentials($region, $credential)) {
return null;
}
return $this->aws->createCloudWatchLogs($config);
} | codesearch |
Evaluation of Glomus mosseae as Biocontrol Agents against Rhizoctonia solani on Tomato | R. solani is one of the phytopathogens that attack tomato cultivated causing seed decay, root and crown rot. The ability of arbuscular mycorrhiza (AM) to suppress root diseases caused by soilborne pathogens has been intensively studied in the last thirty years. The efficacy of AM ( Glomus mosseae ) as biological agents was assayed against R. solani on tomato seeds and seedling in greenhouse and field. The results appeared ability of AM ( Glomus mosseae ) for the suppression of R. solani at transplant time (day 30) in greenhouse experiment (76%) and field experiment results appeared significant differences at disease index and disease severity of tomato plants in mycorrhiza treatment (21%, 1 respectively). The mycorrhiza treatment results was positive influenced on plant growth and health indicators too (tomato seeds germination, fresh weight, dry weight, roots volume and fruit weight). Keywords: Rhizoctonia solani, Glomus mosseae, Biological agent, Tomato. | s2orc_title_abstract |
Specific proliferative T-cell responses were induced in the lymph node cells (LNC) of mice immunised with a sucrose density gradient purified preparation of respiratory syncytial (RS) virus or an immunoaffinity purified preparation of the F glycoprotein. Inhibition studies and flow cytometric analysis showed that the responding cell population were CD4+ T cells. The cytokines produced by virus-specific and F-specific cells were assessed using the CTLL cell line. Peak quantities of cytokine were consistently detected in the supernatants of stimulated cultures 24 h prior to maximum proliferation. The proportion of IL-2 released was determined by blocking IL-2 activity with an anti-IL-2 monoclonal antibody. In cultures of RS virus primed LNC challenged with whole virus there was a switch of cytokine production from 70% IL-2 at day 3 to 80% IL-4 by 6 days of culture. In contrast, LNC cultures from mice immunised with F protein secreted 75-100% IL-2 throughout the culture period. These data suggest that after 6 days of challenge with viral antigen, the RS virus-primed LNC response consists of T helper cells which are predominantly of the Th2 subset, secreting IL-4, whilst F protein-primed LNC secrete large quantities of IL-2 and can therefore be classified as predominantly of the Th1 subset. | Human peripheral blood mononuclear cell (PBMC) proliferative responses to live respiratory syncytial (RS) virus, formalin-inactivated RS (Fl-RS) virus, RS virus F (fusion) protein, and RS virus G (attachment) protein were assessed. All donors responded to challenge with whole RS virus antigens and F and G proteins. F protein responses elicited higher levels of response than equivalent concentrations of G protein in nine out of ten adult RS-seropositive donors. Stimulation of PBMC induced low levels of interleukin 2 (IL-2), interferon gamma (IFN-gamma), IL-4, and IL-10 production. Human RS virus-specific T cell lines were generated from peripheral blood cultures following in vitro stimulation with RS virus antigens. All lines generated were shown to be MHC class II restricted. Characterisation of the lines was carried out by determining the levels of IL-2, IFN-gamma, IL-4, and IL-10 in culture supernatants. T cell lines enriched for RS virus-specific cells provided a more sensitive system than PBMC cultures for the detection of cytokines. The pattern of cytokine production varied for the individual lines, and the detection of TH1 and TH2 cytokines was dependent on the nature of the stimulating RS virus antigen. Live RS virus induced a TH1 pattern of cytokines (IL-2 and IFN-gamma), whereas FI-RS virus induced the production of both TH1 and TH2 cytokines. In addition, TH lines specific for individual RS virus proteins produced different cytokine profiles. F protein-specific lines generated TH1-type cytokines (IL-2 and IFN-gamma), whereas G protein-specific lines generated TH2-type cytokines (IL-4 and IL-10). | s2orc_abstract_citation |
LOVE the fastener to it | Bought one for myself and my mother (both have the same name)! She uses hers for her luggage cart in the nursing home she lives in when she does her laundry, etc. Mine goes on my luggage and I can spot it at long distances. LOVE the fastener to it......easy to use and bright! | amazon_reviews |
Iterable of all pending work items. | def pending_work_items(self):
""
pending = self._conn.execute(
"SELECT * FROM work_items WHERE job_id NOT IN (SELECT job_id FROM results)"
)
return (_row_to_work_item(p) for p in pending) | codesearch |