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A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients. Delirium is a common and serious acute neuropsychiatric syndrome which is often missed in routine clinical care. Inattention is the core cognitive feature. Diagnost...
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A happiness magnet? Reviewing the evidence for repetitive transcranial magnetic stimulation in major depressive disorder. First, to conduct a historical review of the evidence for repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder and determine a clinical algorithm. Second, to identify op...
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VP2 of Chicken Anaemia Virus Interacts with Apoptin for Down-regulation of Apoptosis through De-phosphorylated Threonine 108 on Apoptin. Chicken anaemia virus (CAV) is an important contagious agent that causes immunosuppressive disease in chickens. CAV Apoptin is a nucleoplasmic shuffling protein that induces apoptosis...
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Immunohistochemical detection of procalcitonin in fibrolamellar hepatocellular carcinoma. A 25-year-old woman with fever and epigastric pain was referred to our hospital. Blood examination showed significant liver dysfunction, markedly high C-reactive protein (CRP 19.1 mg/dL) and procalcitonin (48.3 ng/mL) levels. Dyna...
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Gambling and the COVID-19 pandemic: A scoping review. The impact of COVID-19 on mental health is tremendous. Since the beginning of the pandemic, several actors have raised concerns about the impact of the pandemic on gambling. Many actors fear a switch to online gambling in the context of the closure of many land-base...
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Identification of Brassinosteroid Signaling Complexes by Coimmunoprecipitation and Mass Spectrometry. A combination of coimmunoprecipitation (coIP) of tagged proteins followed by protein identification and quantitation using Liquid Chromatography Mass Spectrometry/Mass Spectrometry (LCMS/MS) has proven to be a reliable...
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Changes in normothermia during surgery. The aim of the study was to monitor changes in normothermia in patients undergoing surgery under general anaesthesia.
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Haptoglobin expression correlates with tumor differentiation and five-year overall survival rate in hepatocellular carcinoma. Elevated serum haptoglobin (Hp) is identified as a prognostic marker in multiple types of solid tumors, which is correlated with poor prognosis. HCC is one of the major causes of cancer deaths i...
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Cell type-specific novel long non-coding RNA and circular RNA in the BLUEPRINT hematopoietic transcriptomes atlas. Transcriptional profiling of hematopoietic cell subpopulations has helped to characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood d...
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Experiences of Body Image Changes in Chinese Patients Living with Inflammatory Bowel Disease: A Descriptive Qualitative Study. Body image changes are common among patients living with inflammatory bowel disease (IBD) because of the illness and related treatments. Currently, there is little known about how those patient...
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Keeping the power on to home medical devices. Advances in digital health technologies have revolutionised home medical care. Yet many home medical devices (HMEDs, which includes devices referred to as 'life support equipment') rely upon a stable and resilient electricity supply. For users of HMEDs, interruptions to ele...
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Morphological Reconstruction-Based Image-Guided Fuzzy Clustering with a Novel Impact Factor. The guided filter is a novel explicit image filtering method, which implements a smoothing filter on "flat patch" regions and ensures edge preserving on "high variance" regions. Recently, the guided filter has been successfully...
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Chinese Medicine for Alzheimer's Disease: A Meta-Analysis of Randomized Controlled Trials. To evaluate the effificacy of oral Chinese medicine (CM) in comparison with donepezil, a cholinesterase inhibitor (ChEI), for the treatment of Alzheimer's disease (AD).
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Label-free Separation of Circulating Tumor Cells Using a Self-Amplified Inertial Focusing (SAIF) Microfluidic Chip. Circulating tumor cells (CTCs) are rare cells existing in the bloodstream with a relatively low number, which facilitate as a predictor of cancer progress. However, it is difficult to obtain highly purifi...
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Genome-wide identification of heat shock factors and heat shock proteins in response to UV and high intensity light stress in lettuce. Heat shock factors (Hsfs) and Heat shock proteins (Hsps) belong to an essential group of molecular regulators involved in controlling cellular processes under normal and stress conditio...
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Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein. Apolipoprotein A1 (APOA1), the major protein of high-density lipoprotein (HDL), contains 10 helical repeats that play key roles in protein-protein and protein-lipid interactions. The current structural model for HDL proposes that...
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Effects of muscle damage on 31 P-MRS indices of energetic status and sarcolemma integrity in young mdx mice. The article of Lopez et al describes the use of a multi-parametric MR approach to study muscle T 2 relaxation times and 31 P-MRS indices of energetics and sarcolemma integrity in a mouse model of DMD, the mdx mo...
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Optimisation of a batch thermal combustion method using a tube furnace oxidation system (pyrolyser) and LSC for carbon-14 determination in environmental matrices. Accelerator mass spectrometry and benzene synthesis coupled with liquid scintillation spectrometry are often used for accurate measurements of 14 C activity ...
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N-dihydrogalactochitosan-supported tumor control by photothermal therapy and photothermal therapy-generated vaccine. Photothermal therapy (PTT) is recently clinically established cancer therapy that uses near-infrared light for thermal ablation of solid tumors. The biopolymer N-dihydrogalactochitosan (GC) was shown in ...
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Automated recognition of the pericardium contour on processed CT images using genetic algorithms. This work proposes the use of Genetic Algorithms (GA) in tracing and recognizing the pericardium contour of the human heart using Computed Tomography (CT) images. We assume that each slice of the pericardium can be modelle...
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Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering. Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue enginee...
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Determination of the just suspended speed for solid particle in torus reactor. With the considerable use of pipelines and reactors in the engineering industry, determining the deposition velocity enabling hydraulic transport is of utmost importance. This has been investigated throughout the years, scrupulously in sever...
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[Preliminary study on effect of Gegen Qinlian Decoction on enzyme activity, gene expression and methylation level of FASN in adipose tissue of rats with insulin resistance]. To investigate the effect of Gegen Qinlian Decoction(GQD) on enzyme activity, gene expression and methylation level of fatty acid synthase(FASN) i...
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A meta-synthesis of qualitative studies of the link between anxiety, depression and perfectionism: implications for treatment. Meta-analyses show an association between perfectionism and depression and anxiety (negative affect), and that therapy for perfectionism impacts positively on negative affect. No systematic rev...
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Mucoadhesive Particles: A Novel, Prolonged-Release Nanocarrier of Sitagliptin for the Treatment of Diabetics. Sitagliptin (MK-0431) is a widely and commonly used oral hypoglycemic drug in the treatment of type 2 diabetes mellitus; patients typically take higher doses of this drug (50 mg, twice daily). One drawback is t...
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Major Stress-Related Symptoms During the Lockdown: A Study by the Italian Society of Psychophysiology and Cognitive Neuroscience. The clinical effects of the Covid-19 pandemic are now the subject of numerous studies worldwide. But what are the effects of the quarantine imposed by the states that implemented the measure...
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Radial/Ulnar angioplasty in selected patients undergoing elective angiography or PCI using complex forearm approach. Angioplasty on the radial artery have been performed with good success rates in patients with critical hand ischemia. We sought to assess the feasibility and safety of radial angioplasty on complex radia...
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False-negative Results of Human Immunodeficiency Virus (HIV) Rapid Testing in HIV Controllers. Serological assays were performed on 85 human immunodeficiency virus-controller samples . 6% presented a negative rapid screening test 7% presented an indeterminate Western blot. The enzyme immunoassay ratio decreased in cont...
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Paratesticular rhabdomyosarcoma-Impact of locoregional approach on patient outcome: A report from the European paediatric Soft tissue sarcoma Study Group (EpSSG). Paratesticular rhabdomyosarcoma (PT RMS) is rare compared to benign scrotal pathology. Inappropriate first surgery (InFS) required supplementary treatment to...
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Adjuvant Chemotherapy for Gastric Cancer Patients with Mismatch Repair Deficiency or Microsatellite Instability: Systematic Review and Meta-Analysis. Mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) status serves as a predictor of a poor response to adjuvant chemotherapy among stage 2 colon c...
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Targeting Amyloids with [ 18 F]AV-45 for Medullary Thyroid Carcinoma Positron Emission Tomography/Computed Tomography Imaging: A Pilot Clinical Study. Medullary thyroid carcinoma (MTC) is a malignant neuroendocrine tumor with a high recurrence rate. Amyloid plaques formed from the misfolding of calcitonin are the key c...
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Deciphering the role of nanostructured materials in the point-of-care diagnostics for COVID-19: a comprehensive review. The infamous COVID-19 outbreak has left a crippling impact on the economy, healthcare infrastructure, and lives of the general working class, with all the scientists determined to find suitable and ef...
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Assessment of mask-wearing adherence and social distancing compliance in public places in Hamadan, Iran, during the COVID-19 pandemic. The determination of the rate of social distancing compliance and mask-wearing adherence is essential to address the health aspects of COVID-19. The present study aimed to estimate the ...
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National report on aggressions to physicians in Spain 2010-2015: violence in the workplace-ecological study. Aggressions against health staff is a phenomenon that is not widely studied worldwide. To date, there is no national study analyzing this situation in Spain. Our objective is to describe and analyze aggressions ...
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Modeling the spread of capripoxvirus among livestock and optimal vaccination strategies. Capripox is an important transboundary animal disease that is endemic across Africa, the Middle East, and some parts of Asia. The disease is highly contagious and considered to be a major obstacle causing significant economic loses...
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Pretreatment optimisation and kinetics of batch anaerobic digestion of liquidised OFMSW treated with NaOH: Models verification with experimental data. The enormous generation of municipal solid waste (MSW) due to increased urbanization is causing threat to the environment. MSW is a mixed waste and it comprises of organ...
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Automated deep learning design for medical image classification by health-care professionals with no coding experience: a feasibility study. Deep learning has the potential to transform health care; however, substantial expertise is required to train such models. We sought to evaluate the utility of automated deep lear...
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Surmising synchrony of sound and sight: Factors explaining variance of audiovisual integration in hurdling, tap dancing and drumming. Auditory and visual percepts are integrated even when they are not perfectly temporally aligned with each other, especially when the visual signal precedes the auditory signal. This wind...
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Depression in Poststroke Aphasia. Purpose The aim of this tutorial is to provide speech-language pathologists with foundational knowledge of poststroke depression comorbidly occurring with aphasia. Given the negative effect of depression on functional outcomes and mortality, it is crucial that speech-language pathologi...
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Fertilization accelerates the decomposition of microplastics in mollisols. Agricultural films composed of low-density polyethylene (LDPE) have been widely used in farmland, and LDPE microplastics (LDPE-MPs) produced from LDPE degradation can pollute soils and can exert negative effects on biota. Both nitrogen (N) and p...
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Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer's disease. Although many therapeutic strategies for Alzheimer's disease (AD) have been explored, these strategies are seldom used in the clinic. Therefore, AD therapeutic research is still urgently needed. One major ch...
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UK audit of target volume and organ at risk delineation and dose optimisation for cervix radiotherapy treatments. Assessment of the extent of variation in delineations and dose optimisation performed at multiple UK centres as a result of interobserver variation and protocol differences.
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Transjugular Portosystemic Shunt Reductions: A Retrospective Single-Center Experience. To report the results of transjugular intrahepatic portosystemic shunt (TIPS) reductions for hepatic encephalopathy (HE), acute liver failure (ALF), and pulmonary hypertension (PH).
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Care of the stoma: complications and treatments. Quality patient education of how to care for their stoma improves patient outcomes and enhances quality of care and efficacy. There is a need for home visits to assist ostomates with rehabilitation of their stoma formation, as they often feel stigmatised and are likely t...
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Fabrication and sensing properties of phenolphthalein based colorimetric and turn-on fluorogenic probe for CO 3 2- detection and its living-cell imaging application. Herein, an easy assembled colorimetric and ''turn-on'' fluorescent sensor (probe P4SC) based on phenolphthalein was developed for carbonate ion (CO 3 2- )...
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Enhancement of enzyme activities and VFA conversion by adding Fe/C in two-phase high-solid digestion of food waste: Performance and microbial community structure. Two-phase high-solid digestion is conducive to the degradation of food waste. In this study, Fe/C was added in high-solid digestion in different acidificatio...
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Framework for the environmental impact assessment of operational shipping. Shipping is an important source of pollution affecting both atmospheric and aquatic environments. To allow for efficient mitigation of environmental degradation, it is essential to know the extent of the impacts of shipping in relation to other ...
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Evaluating the quality of remote sensing products for agricultural index insurance. Agricultural index insurance contracts increasingly use remote sensing data to estimate losses and determine indemnity payouts. Index insurance contracts inevitably make errors, failing to detect losses that occur and issuing payments w...
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Comparison of 10-Year Survival Outcomes for Early Single Hepatocellular Carcinoma following Different Treatments. To compare the actual 10-year survival outcomes of early single hepatocellular carcinoma (HCC) patients between 3 first-line treatments: radiofrequency ablation (RFA), surgical resection (SR), or transplant...
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A Critical Review on Transplacental Transfer of Per- and Polyfluoroalkyl Substances: Prenatal Exposure Levels, Characteristics, and Mechanisms. Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFASs) has aroused public concerns as it can pose multiple health threats to pregnant women and cause advers...
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Predator-Prey Interactions in the Anthropocene: Reconciling Multiple Aspects of Novelty. Ecological novelty, when conditions deviate from a historical baseline, is increasingly common as humans modify habitats and communities across the globe. Our ability to anticipate how novelty changes predator-prey interactions wil...
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Spinal cord infarction caused by extensive aortic intramural hematoma. We report the case of a 62-year-old Caucasian man, an ex-smoker, who presented to the emergency room complaining of intense lower back pain followed by immediate bilateral loss of inferior limbs motor function. Clinical examination showed complete p...
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Dystonia is a Common Phenotypic Feature of MEGDEL Syndrome. In Response To: Giron C, Roze E, Degos, B, Méneret A, Jardel C, Lannuzel A, et al. Adult-onset generalized dystonia as the main manifestation of MEGDEL syndrome. Tremor Other Hyperkinet Mov. 2018; 8. doi: 10.7916/D8VM5VBQ.
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Hospital Enforcement of Early Cholecystectomy for Acute Cholecystitis. International guidelines state that early laparoscopic cholecystectomy (ELC) is appropriate for all severity grades of acute cholecystitis and leads to reduced hospital stays and costs. A multicenter prospective randomized controlled trial recommend...
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Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2-R1-dependent ribonucleotide reductase. Deoxyribonucleotides are DNA building blocks and are produced de novo by reduction of ribose to deoxyribose. This reduction is catalyzed by ribonucleotide reductase (RNR), a heterodimeric tetramer e...
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Fañanas cells-the forgotten cerebellar glia cell type: Immunocytochemistry reveals two potassium channel-related polypeptides, Kv2.2 and Calsenilin (KChIP3) as potential marker proteins. For long times astrocytes had been regarded as supporting cells, passively filling the spaces between neuronal cell bodies and their ...
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Simple laparoscopic repair of perforated peptic ulcer without omental patch. We evaluated the outcomes of laparoscopic repair of perforated peptic ulcers using simple closure only.
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Implementation of a Prevention Program Based on Adapted Physical Activity and Recommendations for Adolescents and Young Adults with Cancer: PREVAPAJA Study. Purpose: In Europe, 20,000 Adolescent and Young Adults (AYAs) aged 15-25 years are diagnosed with cancer annually. Although prognosis is good, AYA cancer survivors...
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Attenuation-based kV pair selection in dual source dual energy computed tomography angiography of the chest: impact on radiation dose and image quality. The purpose of this study was to evaluate the impact of attenuation-based kilovoltage (kV) pair selection in dual source dual energy (DSDE)-pulmonary embolism (PE) pro...
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Generating retinal flow maps from structural optical coherence tomography with artificial intelligence. Despite advances in artificial intelligence (AI), its application in medical imaging has been burdened and limited by expert-generated labels. We used images from optical coherence tomography angiography (OCTA), a re...
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Physical and emotional well-being and support in newly diagnosed head and neck cancer patient-caregiver dyads. The purpose of this study was to examine the physical and emotional well-being and social support in newly diagnosed head and neck cancer (HNC) patients and caregivers and identify sociodemographic, clinical, ...
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Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model. The aim of this work was to develop a new in vitro lipolysis-permeation model to predict the in vivo absorption of fenofibrate in self-nanoemulsifying drug delivery syst...
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Use of the Menstrual Cycle to Enhance Female Sports Performance and Decrease Sports-Related Injury. The impact of the menstrual cycle on female sports performance is a growing interest area in sports and athletics. In March 2017, the British Journal of Sports Medicine, published the article, "Sport, Exercise and the Me...
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Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice. Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer's disease (AD). Accumulation of toxic amyloid-β (Aβ) speci...
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Monitoring and adapting endurance training on the basis of heart rate variability monitored by wearable technologies: A systematic review with meta-analysis. To systematically perform a meta-analysis of the scientific literature to determine whether the outcomes of endurance training based on heart rate variability (HR...
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Shared yet dissociable neural codes across eye gaze, valence and expectation. The direction of the eye gaze of others is a prominent social cue in primates and is important for communication 1-11 . Although gaze can signal threat and elicit anxiety 6,12,13 , it remains unclear whether it shares neural circuitry with st...
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The relationship between intracranial pressure and neurocognitive function before and after the repair of a skull injury. This study examines the relationship between intracranial pressure (ICP) changes after skull injury repair and neurocognitive function before and after the repair.
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MicroRNA31 and MMP-1 contribute to the differentiated pathway of invasion -with enhanced epithelial-to-mesenchymal transition- in squamous cell carcinoma of the skin. Epithelial to mesenchymal transition (EMT) is an important mechanism of invasion in cutaneous squamous cell carcinomas (cSCCs) and has been found to be e...
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Animal board invited review: Animal source foods in healthy, sustainable, and ethical diets - An argument against drastic limitation of livestock in the food system. Animal source foods are evolutionarily appropriate foods for humans. It is therefore remarkable that they are now presented by some as unhealthy, unsustai...
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Anemic Women are More at Risk of Injectable Contraceptive Discontinuation due to Side Effects in Ethiopia. This paper investigates the importance of women's physiological condition, alongside sociocultural factors, for predicting the risk of discontinuation of the injectable contraceptive due to side effects in Ethiopi...
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Biosynthesis pathways and strategies for improving 3-hydroxypropionic acid production in bacteria. 3-Hydroxypropionic acid (3-HP) represents an economically important platform compound from which a panel of bulk chemicals can be derived. Compared with petroleum-dependent chemical synthesis, bioproduction of 3-HP has at...
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-controlled trial. Diabetes mellitus is associated with inadequate delivery of oxygen to tissues. Cellular hypoxia is associated with mitocho...
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Methodological tools to study species of the genus Burkholderia. Bacteria belonging to the Burkholderia genus are extremely versatile and diverse. They can be environmental isolates, opportunistic pathogens in cystic fibrosis, immunocompromised or chronic granulomatous disease patients, or cause disease in healthy peop...
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The Evolving Role of Public Health in Medical Education. Medical education in the twentieth century was largely influenced by the Flexner Report, with significant proportions of instruction dedicated to the molecular underpinnings of the pathologic pathways and minimal mention of the socio-ecological determinants of he...
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Validation of ICD-10 codes shows intracranial venous thrombosis incidence to be higher than previously reported. Intracranial venous thrombosis (ICVT) accounts for around 0.5% of all stroke cases. There have been no previously published studies of the International Classification of Diseases, Tenth Edition (ICD-10) val...
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A comprehensive analysis of the Lactuca sativa, L. transcriptome during different stages of the compatible interaction with Rhizoctonia solani. The leafy green vegetable Lactuca sativa, L. is susceptible to the soil-born fungus Rhizoctonia solani AG1-IB. In a previous study, we reported on the transcriptional response ...
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COMPLEX CHEST WALL DEFORMITY CAUSING CARDIAC ARREST: A PECULIAR PEDIATRIC CASE. Congenital chest wall deformities are common in children, causing self and parental concern mainly due to cosmesis. These defects rarely cause severe symptoms in patients.
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New answers to the old RIDDLE: RNF168 and the DNA damage response pathway. The chromatin-based DNA damage response pathway is tightly orchestrated by histone post-translational modifications, including histone H2A ubiquitination. Ubiquitination plays an integral role in regulating cellular processes including DNA damag...
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Designing Ecological Security Patterns Based on the Framework of Ecological Quality and Ecological Sensitivity: A Case Study of Jianghan Plain, China. Researchers and managers of natural resource conservation have increasingly emphasized the importance of maintaining a connected network of important ecological patches ...
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The Impact of Sex on Strength Training in Adults With Cardiovascular Disease. Cardiovascular disease (CVD) is the leading killer of American males and females. Outcomes of treatment for CVD have historically been worse in females than in males. The inability to recover, may be, at least in part, due to lower levels of ...
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Cephalic muscle development in the Australian lungfish, Neoceratodus forsteri. Lungfishes are the extant sister group of tetrapods. As such, they are important for the study of evolutionary processes involved in the water to land transition of vertebrates. The evolution of a true neck, that is, the complete separation ...
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Integrating Genomics Into Management of Fibrotic Interstitial Lung Disease. Fibrotic interstitial lung diseases (ILDs) have a high mortality rate with an unpredictable disease course and clinical features that frequently overlap. Recent data indicate important roles for genomics in the mechanisms underlying susceptibil...
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COVID-19 Suspected myopericarditis without pulmonary involvement. Myopericarditis is a rare consequence of COVID-19 infection. Although extremely rare, COVID-19 can present without pulmonary involvement, and there have been reports of isolated cardiac involvement in one prior case We report a case of a young African Am...
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Part by Part: Synthetic Biology Parts Used in Solventogenic Clostridia. The solventogenic Clostridia are of interest to the chemical industry because of their natural ability to produce chemicals such as butanol, acetone and ethanol from diverse feedstocks. Their use as whole cell factories presents multiple metabolic ...
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The Pharmaceutical Industry in 2021. An Analysis of FDA Drug Approvals from the Perspective of Molecules. Similar to last year, 2021 will be remembered for the COVID-19 pandemic. Although five vaccines have been approved by the two most important drug regulatory agencies, namely the US Food and Drug Administration (FDA...
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Polyglutamine-Related Aggregates Can Serve as a Potent Antigen Source for Cross-Presentation by Dendritic Cells. Protective MHC class I-dependent immune responses require an overlap between repertoires of proteins directly presented on target cells and cross-presented by professional APC, specifically dendritic cells. ...
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An analysis of the radiological factors associated with respiratory failure in COVID-19 pneumonia and the CT features among different age categories. To investigate CT patterns of COVID-19 pneumonia associated with respiratory failure (RF) focused on the distribution of lesions.
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Prevalence of COVID-19 Mimics in the Emergency Department. Objective Due to the lack of specific clinical manifestations and symptoms, it is difficult to distinguish COVID-19 from mimics. A common pitfall is to rush to make a diagnosis when encountering a patient with COVID-19-like symptoms. The present study describes...
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Comparison of appendicular lean mass indices for predicting physical performance in Korean hemodialysis patients: A cross-sectional study. Few studies have examined the optimal adjustment indices for predicting low muscle strength or physical performance in hemodialysis (HD) patients. Thus, the present study aimed to i...
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The budget impact of adding pralsetinib to a US health plan formulary for treatment of non-small cell lung cancer and thyroid cancer with RET alterations. BACKGROUND: Lung cancer is the leading cause of cancer death in the United States. Non-small cell lung cancer (NSCLC) accounts for 80% to 85% of all lung cancers. Th...
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A reliable and easy to transport quality control method for chlamydia and gonorrhoea molecular point of care testing. Quality control (QC) is an essential component of point-of-care testing programs. In the context of a randomised-controlled trial (TTANGO) using GeneXpert (Xpert) Chlamydia trachomatis and Neisseria gon...
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Experience with thoracic endovascular aortic repair applied in treating Stanford type B aortic dissection: An analysis of 98 cases. Thoracic endovascular aortic repair (TEVAR) has been frequently applied in Stanford type B aortic dissection since thoracic aortic diseases were first treated with artificial vessels.
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Discovery of BP3 as an efficacious proteolysis targeting chimera (PROTAC) degrader of HSP90 for treating breast cancer. Heat shock protein 90 (HSP90) is involved in the stabilization and activation of oncoproteins, rendering it essential for oncogenic transformation. However, the HSP90 inhibitors evaluated to date have...
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The Contribution of Psychosocial Interventions to Precision Medicine for Heart Health. This paper reviews the value of incorporating psychosocial interventions into precision medicine for heart health. First, we review the empirical literature on prevalence of common mental health comorbidities among individuals with c...
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Forces controlling organ growth and size. One of the fundamental questions in developmental biology is what determines the final size and shape of an organ. Recent research strongly emphasizes that besides cell-cell communication, biophysical principals govern organ development. The architecture and mechanics of a tiss...
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Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation. Immune cell activation and differentiation occurs concurrently with metabolic reprogramming. This ensures that activated cells generate the energy and substrates necessary to perform their specified function. Likewi...
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Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts. Proepicardium (PE) cells generate cardiac fibroblasts, smooth muscle cells (SMCs) and endothelial cells that form coronary arteries. T-box18 (Tbx18) is a well-known m...
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Association between type 2 diabetes status and osteoarthritis in adults aged ≥ 50 years. Increasingly, studies have addressed the possible association between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA), although this remains an issue of controversy. Our aim in this study was to investigate the association ...
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Urinary proteomics to diagnose chronic active antibody-mediated rejection in pediatric kidney transplantation - a pilot study. Chronic antibody-mediated rejection (cABMR) is the main cause of long-term renal graft loss. Late-stage diagnosis is made by detecting donor-specific antibodies (DSA) in blood combined with typ...
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SeedVicious: Analysis of microRNA target and near-target sites. Here I describe seedVicious, a versatile microRNA target site prediction software that can be easily fitted into annotation pipelines and run over custom datasets. SeedVicious finds microRNA canonical sites plus other, less efficient, target sites. Among o...
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