PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
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101
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stringlengths 4
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|---|---|---|---|
36,275,975
|
recurr rate explor clinic factor pituitari adenoma surgeri systemat review meta analysi base comput artifici intellig system first line treatment patient type pituitari adenoma tran sphenoid surgeri consid preval condit global treatment quit common recurr pituitari adenoma recogn occurr medic field howev limit comprehens research analysi predict factor recurr rate clinic factor impact relaps rate identifi recurr rate pituitari adenoma clinic factor associ could help increas remiss rate increas focus specif aspect earli diagnosi improv treatment
|
D010911;D000236
|
T191
|
36,275,974
|
spatio tempor attent mechan base approach remain use life predict turbofan engin time seri data generat turbofan engin great degre complex dynam present recurr neural network common use model forecast remain use life rul relationship sampl data taken account issu gradient explos view spatio tempor attent model propos comprehens relat tempor associ data featur hidden state data featur space time posit code perform tempor relationship avoid use recurr neural network experiment result show combin two dimens predict perform model signific improv compar differ method four data set commerci modular aerospac propuls system simul c mapss stabil predict accuraci spatio tempor attent model better altern method
|
D016571
|
T170
|
36,275,973
|
use aaeh net attent base auxiliari extract hybrid subsampl network semant segment semant segment base deep learn undergon remark advanc recent year howev due neglect shallow featur problem inaccur segment persist address issu semant segment network attent base auxiliari extract hybrid subsampl network aaeh net suggest studi extract deep inform shallow featur complementari enhanc extract modul ceem util network result edg segment model improv moreov reduc loss featur hybrid subsampl modul hsm introduc meanwhil global max pool global avg pool modul gagm design attent modul enhanc featur global import inform maintain featur continu propos aaeh net evalu three dataset aerial drone imag dataset massachusett road dataset massachusett build dataset three dataset aaeh net achiev higher accuraci u net reach respect time propos network obtain best valu evalu metric three dataset compar current popular algorithm
|
D016571;D007091
|
T170;T066
|
36,275,972
|
edg awar graph neural network multi hop path reason knowledg base multi hop path reason knowledg base aim find answer entiti input question walk along path tripl graph structur data crucial branch knowledg base question answer kbqa research field previous studi reli deep neural network simul way human solv multi hop question consid latent relat inform contain connect edg lack measur correl specif relat input question address challeng propos edg awar graph neural network multi hop path reason task first queri node direct ad candid subgraph retriev knowledg base construct term queri graph graph construct strategi make possibl enhanc inform flow question node subsequ messag pass step second question relat inform contain relat ad entiti node represent graph updat meanwhil relat represent updat final attent mechan use weight contribut neighbor node inform neighbor node relat queri inject new node represent experiment result metaqa pathquest larg pql benchmark demonstr propos model achiev higher hit f score baselin method larg margin moreov ablat studi show graph construct graph updat algorithm contribut perform improv
|
D016571;D051188
|
T170
|
36,275,971
|
investig differenti power young internet addict questionnair use decis stump tree internet addict one serious consequ recent advanc use social media earli detect internet addict essenti harm necessari time effect treatment
|
D000082424;D016739
|
T048
|
36,275,970
|
iot speech recognit applic mass sport data monitor base dynam adapt recommend algorithm paper exist dynam adapt recommend method studi combin practic applic scheme transform actual dynam adapt recommend problem user microblog inform dynam adapt weight fusion method propos base experiment verif real time dynam adapt recommend system final design speech recognit internet thing take natur languag problem research object long time take sound signal research topic paper analyz applic dynam adapt recommend internet thing speech recognit mass sport data monitor simul result show system paper conveni user monitor exercis indic real time mobil client time queri exercis histor data compar exercis data network termin therebi improv exercis method exercis load user access motion monitor modul see past float state motion paramet intuit graph contain queri metric heart rate bodi temperatur kinet energi puls weight due divers complex peopl differ person characterist busi environ sport data monitor system also need design accord scope use paper analyz requir motion data monitor system provid system architectur design basic data produc detail inform system
|
D013067
|
T041
|
36,275,969
|
studi mechan electroacupunctur allevi viscer pain ngf express viscer pain unbear natur method need reliev electroacupunctur relat new techniqu help reliev viscer pain improv blood circul provid energi clog part bodi howev analges effect mechan colorect pain still unknown studi viscer pain model electroacupunctur rat compar discuss use nanocompon stimul express mechan nerv growth factor colorect pain electroacupunctur observ express mechan nerv growth factor viscer pain relief rat induc nanocompon electroacupunctur result show nanocompon effect reliev viscer pain action electroacupunctur ngf activ endogen prolifer migrat differenti integr nsc promot nerv regener recoveri injuri
|
D015671;D059265;D015179
|
T061;T184;T191
|
36,275,968
|
factor analysi complianc rate hypertens detect control self assess control communiti outpati clinic understand relat influenc factor outpati hypertens detect control self test control complianc rate
|
D012647;D006973
|
T055;T047;T041
|
36,275,967
|
social forc evacu model guid base fuzzi cluster two layer fuzzi infer current emerg manag research main specifi posit evacu guid knowledg base experi disregard subject perceiv decis make pedestrian caught emerg situat therefor paper fuzzi infer system pedestrian select guid design perspect pedestrian crowd evacu model guid limit vision construct first select indoor evacu peopl limit vision context number optim initi posit guid determin gaussian fuzzi cluster algorithm next two layer fuzzi infer system base multifactor pedestrian select guid establish comprehens perspect manag pedestrian improv social forc evacu model guid construct comparison evacu time evacu process known method differ scene popul distribut analyz simul result show guid set scheme improv model conduc reduc evacu time balanc exit util model provid basi emerg manag decis make depart formul flexibl guidanc strategi
|
D008962;D000069636
|
T062;T170;T098
|
36,275,966
|
analysi influenc human resourc econom develop minor area base data mine order break bottleneck human capit stock restrict local econom growth typic western region backward nation econom develop research analysi impact human resourc econom develop ethnic region base data mine propos basi systemat review current situat theoret basi relationship human capit econom growth method combin normat research empir research adopt theori macroeconom develop econom region econom synthes research human capit econom develop certain western region analyz establish econometr model result show averag valu year taken inspect index contribut rate show contribut human capit stock econom growth small indic physic capit stock still main drive forc local econom develop conclud research provid relev recommend human capit develop achiev sustain local econom develop
|
D057217;D057225
|
T081;T066
|
36,275,965
|
artifici intellig base bio medic stroke predict analyt system use machin learn approach stroke relat disabl major negat effect econom well person left untreat stroke fatal accord find studi peopl stroke general abnorm biosign patient abl obtain prompt therapi manner care monitor biosign precis assess real time analysi perform contrari stroke diagnosi predict system reli imag analysi technolog ct mri expens also hard use studi develop machin learn algorithm predict stroke brain predict carri real time sampl electromyographi emg data studi use synthet sampl train support vector machin svm classifi test conduct real time sampl improv accuraci predict sampl generat use data augment principl support train vast data simul conduct test efficaci model result show propos classifi achiev higher rate classif accuraci exist method furthermor seen rate precis recal f measur higher propos svm method
|
D001185;D020521
|
T090;T047;T073;T066
|
36,275,964
|
bp network model base sclboa hous price forecast butterfli optim algorithm boa new swarm intellig algorithm mimick behavior butterfli howev still much room improv order enhanc converg speed accuraci boa present improv algorithm sclboa base siboa incorpor logic map lvi flight mechan logic chaotic map use popul initi lvi flight mechan integr sclboa algorithm evalu perform sclboa conduct mani experi standard test function simul result suggest sclboa capabl high precis optim fast converg effect global optim show method outperform method solv mathemat optim problem final bp network optim accord sclboa sclboa bp verifi avail algorithm simul experi prove practic method build boston hous price predict model train
|
D002080
|
T204
|
36,275,963
|
multi task assign method cloud comput platform base artifici intellig realiz load balanc cloud comput platform big data process method find optim load balanc physic host algorithm cycl adopt present optim load balanc strategi over focus current deploy problem certain limit make system less effici user wait time unnecessarili prolong paper propos task assign method long term resourc load balanc cloud platform base artifici intellig big data tabai maximum posterior probabl physic host calcul use bayesian theori euler formula use calcul similar host largest posterior probabl host threshold host classifi accord threshold determin optim cluster form final set candid physic host improv resourc util extern servic capabl cloud platform combin cluster analysi bay theorem achiev global load balanc time dimens experiment result show tabai smaller process time tradit load balanc multi task assign method time standard deviat tabai decreas greater extent stronger extern servic capabl
|
D000067917;D001185
|
T090;T073;T066
|
36,275,962
|
high discrimin comparison algorithm comprehens evalu innov abil colleg univers uncertain inform innov abil student one import object need cultiv colleg univers comprehens evalu innov abil discuss studi divid two stage first stage call preliminari evalu main target identifi student innov potenti second stage target object found previous stage evalu quantit rank howev alway difficult quantit evalu innov abil use tradit algorithm base analysi studi propos algorithm quantit evalu innov abil help manag thought fuzzi mathemat data basi evalu accuraci data direct determin qualiti algorithm data structur incomplet probabilist fuzzi set propos studi data structur fulli consid fuzzi problem hesit decis make process save origin detail data maximum extent certain certain inform may lost valu rang determin usual unknown evalu data consist optim model propos solv problem usual certain contradict among evalu data definit consist degre propos studi consist verifi time unknown obtain automat adjust modul activ immedi valu consist degre exceed warn threshold final verifi data consist solut obtain solv optim model sever experi carri verifi effect high discrimin abil algorithm propos studi meanwhil superior algorithm verifi comparison outstand algorithm
|
D000465
|
T170
|
36,275,961
|
applic blur imag process iot action recognit sport danc sport train order process blur imag studi propos combin blur point function invari space multipl blur imag restor deconvolut oper psf function fuzzi invari space combin obtain fuzzi invari space final gradual restor method use perform mani blur imag process step experiment result prove method propos studi avoid nois introduc process multipl deconvolut reduc calcul error improv recoveri effect base fuzzi imag process research studi natur human motion identif action internet thing provid new idea method recognit research kinect somatosensori camera internet thing use captur deep imag three dimension point human skeleton structur obtain sdk base motion characterist human joint studi motion resolut model suitabl internet thing propos model low complex simpl calcul sort characterist base research studi also use softwar engin idea general method system develop design creat sport danc manag inform system use advanc method comput internet maintain train manag achiev optim sport train sport danc mode provid inform manag sport danc athlet train improv effici manag level
|
D003615
|
T056
|
36,275,960
|
lctree base approach mine frequent item real time increas real time stream data knowledg discoveri stream data becom import requir effici data structur store transact scan slide window discov frequent itemset present new method name link compact tree lctree design algorithm use improv data structur creat object tree find frequent itemset linear complex second merg item slide window one scan head link list data structur third implement data structur tail link list locat obsolet node remov easili final lctree abl find exact frequent item data stream reduc time space complex use linear data structur experi dataset differ size type conduct compar propos lctree techniqu well known frequent item mine method includ cantre fp tree dstree cpstree gtree result experi show present algorithm better perform method also confirm promis solut detect frequent item set real time applic
|
D057225
|
T066
|
36,275,959
|
research financi cost account control small medium size enterpris background data mine time data blast ascent web dramat develop inform data need small medium size endeavor affect customari expens execut instruct like mine viabl data inform give effect way techniqu merit consid center innov handl enorm inform inform mine deal lot mind boggl inform effect accord paper talk cycl techniqu appli inform mine expens execut small medium size endeavor work serious small medium size undertak examin depend explor examin monetari inform small medium size ventur join inform mine innov extric use immens monetari inform produc day day administr cycl monetari divis small medium size undertak plan execut inform mine base monetari inform examin small medium size endeavor framework join program plan thought fundament interest explor examin mani benefit ongo bs design chosen util java program languag myeclips program apparatus microsoft sql server data set administr instrument jee advanc stage exemplari apriori inform mine mine techniqu exampl affili rule bunch calcul choic tree calcul complet dissect monetari inform small medium size undertak natur depend give monetari administr branch small medium size endeavor rank director small medium size ventur help monetari data help small medium size endeavor busi pioneer pursu speedi choic plan execut monetari examin framework light inform mine incorpor fundament element sme monetari administr resourc stock administr resourc design board resourc deterior discount resourc inform upkeep execut small medium size undertak monetari administr framework mix inform mine innov program innov small medium size monetari administr effect solid help way develop center serious small medium size undertak partial accomplish definit object framework plan
|
D057225;D003132
|
T078;T066;T097;T081;T057
|
36,275,958
|
method extract build inform remot sens imag base deep learn semant segment remot sens imag import issu remot sens task exist algorithm extract inform accur difficult captur contour object reveal interact inform differ object imag therefor deep learn base method extract build inform remot sens imag propos first deep learn semant segment model deeplabv mixconvd combin convolut kernel differ size use featur recognit regular method base rdrop loss improv accuraci effici contour captur object differ resolut time improv consist dataset fit final propos remot sens imag inform extract method verifi base self built dataset experiment result show propos algorithm effect improv algorithm effici result accuraci good segment perform
|
D000077321
|
T066
|
36,275,957
|
construct applic financi earli warn model base bp neural network order improv earli warn effect enterpris financi crisi manag reduc occurr enterpris financi crisi take list compani exampl combin oper condit list compani financi crisi earli warn indic system built five aspect profit debt pay abil develop abil oper abil cash flow abil addit financi manag earli warn model base bp neural network algorithm built experiment predict show financi crisi earli warn model list compani base bp neural network algorithm crisi predict accuraci accuraci first three year model predict respect accuraci model predict first two year respect first year accuraci rate increas compar predict accuraci logist model fulli reflect financi earli warn model propos research good crisi predict abil
|
D016571;D005376
|
T081;T170;T057
|
36,275,956
|
diagnosi breast cancer use comput intellig model iot applic use comput aid diagnost cad model propos aid detect classif breast cancer work evalu perform multilay perceptron neural network nonlinear support vector machin model classifi breast cancer nodul contour sampl ten morpholog featur use input classifi averag result obtain set simul perform show propos model show good perform exceed term accuraci test set nonlinear support vector machin algorithm stand compar propos multilay perceptron neural network algorithm accuraci fals negat rate neural network model present lower perform nonlinear support vector machin classifi applic propos model averag result obtain promis classif breast cancer
|
D001943
|
T191
|
36,275,955
|
parallel spike neural network base adapt later inhibit mechan object recognit spike neural network snn attract extens attent field machin learn biolog interpret low power consumpt howev accuraci pattern recognit complet surpass deep neural network dnns main reason inher nondifferenti spike neuron make snn unabl train direct gradient descent algorithm also unifi train algorithm snn inspir biolog vision system paper propos parallel convolut snn structur combin adapt later inhibit mechan way dynam evolv time constant train snn propos ensur divers neuron paper verifi effect propos method static dataset neuromorph dataset extend recognit breast tumor experiment result show snn obvious advantag dynam dataset breast tumor also edg base task edg medic imag contain import inform imag kind inform provid great help noninvas accur diagnosi diseas experiment result show propos method close recognit result dnns static dataset perform neuromorph dataset exceed dnns
|
D016571;D001943
|
T170;T191
|
36,275,954
|
cnn lstm facial express recognit method fuse two layer attent mechan explor facial express recognit method found exist algorithm make insuffici use inform key part express emot problem basi convolut neural network long short term memori cnn lstm propos facial express recognit method incorpor attent mechan cnn alstm compar general cnn lstm algorithm mine inform import region effect furthermor cnn lstm facial express recognit method incorpor two layer attent mechan acnn alstm propos conduct compar experi fer process ck dataset cnn alstm acnn alstm patch base acnn pacnn facial express recognit attent net feratt network result show propos acnn alstm hybrid neural network model superior relat work express recognit
|
D000066499
|
T041
|
36,275,953
|
meta path base evalu method enterpris credit risk nowaday small medium size enterpris smes becom essenti part nation economi increas number enterpris evalu credit risk becom hot issu unlik big enterpris massiv data analys hard find enough primari inform smes assess financi status make credit risk evalu result less accur limit lack primari data infer smes credit risk secondari data inform upstream downstream parent subsidiari enterpris attract big attent industri academi target accur evalu credit risk sme studi exploit repres power inform network various kind sme entiti sme relationship solv problem heterogen inform network smes built mine enterpris secondari inform furthermor novel featur name meta path featur propos measur credit risk make us abl evalu financi status smes various perspect experi show propos meta path featur effect identifi smes credit risk
|
D007221
|
T078;T057
|
36,275,952
|
mainten qualiti control medic equip base inform fusion technolog medic field ensur use larg medic equip necessari carri regular mainten larg medic equip process mainten mainten larg scale medic equip medic personnel establish correspond qualiti manag system neglect daili mainten mainten result mani hidden danger medic accid end qualiti control larg medic devic strengthen control event done well comprehens analysi oper method equip carri achiev reason mainten equip therefor paper discuss mainten manag mainten qualiti manag larg medic equip function inform fusion technolog paper summar problem encount mainten medic equip past creat medic qualiti control system manag mainten qualiti control medic equip mainten system medic equip scientif manag theori method use predict adjust inspect account qualiti entir product process equip establish complet qualiti monitor manag system achiev optim mainten econom benefit overal qualiti medic equip comprehens improv data show actual number monitor qualiti control test unit unit pass initi inspect unit pass mainten show mainten qualiti control medic equip base inform fusion technolog effect
|
D000073256
|
T170
|
36,275,951
|
research camouflag human target detect base deep learn task camouflag human target detect target high integr complex environ background difficult identifi lead fals detect miss detect detect algorithm mc yolov propos characterist camouflag target algorithm take yolov basic framework first multispectr channel attent modul embed backbon featur extract network enhanc network abil extract camouflag target featur weaken attent surround background effect improv algorithm antibackground interfer second origin upsampl oper replac lightweight general upsampl oper achiev effect fusion high resolut low level featur map low resolut high level featur map final k mean cluster method use optim anchor box dataset target size generat priori box alloc detect layer increas match degre priori box actual target box improv detect accuraci algorithm train verif carri militari camouflag personnel dataset mcpd precis p recal r mean averag precis map mc yolov algorithm reach respect compar origin yolov model mean averag precis map increas percentag point improv algorithm better detect effect sensit camouflag target achiev accur posit identif camouflag human target propos mc yolov appli personnel search rescu complex battlefield natur disast environ great improv personnel search rescu effici life surviv rate reduc consumpt human materi resourc rescu
|
D000077321
|
T066
|
36,275,950
|
entropi base emot recognit multichannel eeg signal use artifici neural network human experi varieti emot throughout cours daili live includ happi sad rage result effect emot identif system essenti electroencephalographi eeg data accur reflect emot real time although recent studi problem provid accept perform measur still adequ implement complet emot recognit system research work propos new approach emot recognit system use multichannel eeg calcul develop entropi known multivari multiscal modifi distribut entropi mm mdisten combin model base artifici neural network ann attain better outcom exist method propos system test two differ dataset achiev better accuraci exist method gameemo dataset achiev averag accuraci standard deviat valenc arous moreov averag accuraci percentag deap dataset reach valenc arous
|
D004569;D016571
|
T060;T170;T034
|
36,275,949
|
interact cours design develop cognit inspir distanc intern chines educ paper conduct depth research analysi design develop interact cours distanc intern chines languag educ use cognit heurist model frame framework javascript js languag use complet construct virtual supermarket environ initi design basic framework task base coursewar chines languag teach base virtual realiti technolog expert invit conduct two round prestudi index system determin evalu index intern student junior chines class x univers random select research subject divid experiment control group experiment intervent teach content form classroom teach group ask review consolid grammar point learn class class intervent experiment group requir conduct microlearn class classroom grammar point control group requir form review class addit student experiment group follow case studi attitud behavior knowledg profici microlearn record detail assess student accept satisfact microlearn perspect qualit analysi found microlesson teach learn chines foreign languag stimul learner interest learn achiev good interact effect contribut improv learner perform paper combin virtual realiti technolog fulli explor role immers vr technolog play provid cultur scenario target languag maxim use exist technolog vehicl resourc chines teach applic design solv challeng poor interact onlin teach lack socio cultur context long exist oversea chines teach
|
D007802;D020375
|
T065;T171
|
36,275,948
|
research domain specif knowledg graph base roberta wwm ext pretrain model purpos studi solv effect way domain specif knowledg graph construct inform knowledg propos deep learn algorithm extract entiti relationship open sourc intellig roberta wwm ext pretrain model knowledg fusion framework base longest common attribut entiti align technolog bring differ text similar algorithm classif algorithm verif experiment research show name entiti recognit model use roberta wwm ext pretrain model achiev best result term recal rate f valu first f valu roberta wwm ext bilstm crf reach second roberta wwm ext relationship extract model achiev best result compar relat extract model base recurr neural network improv final entiti align algorithm base attribut similar longest common subsequ achiev best result whole find studi provid effect way complet knowledg graph construct domain specif text research serv first step futur research exampl domain specif intellig q
|
D010363;D016571
|
T170;T041
|
36,275,947
|
generat imag inpaint model base edg featur self arrang constraint present imag inpaint method base deep learn achiev better inpaint effect tradit method inpaint result still problem local structur disord blur textur imag involv larg defect area process paper propos second order generat imag inpaint model base edg featur self arrang constraint model consist two part edg repair network imag repair network base self encod edg repair network generat edg defect area accord known inform imag improv edg repair effect minim adversari loss featur match loss imag inpaint network fill defect area edg repair result priori condit basi u net featur self arrang modul fsm propos reconstruct code featur specif scale reconstruct featur skip connect decod layer scale fuse upper layer under featur decod meanwhil guid loss adversari loss reconstruct loss introduc narrow differ repair imag origin imag experiment result show inpaint result propos model stronger structur connect clearer textur perform psnr ssim mean l loss celeba facad place better inpaint method indic algorithm produc inpaint effect high connect structur reason semant fine detail
|
D000465;D007091
|
T170;T066
|
36,275,946
|
effici hybrid featur select method use artifici immun algorithm high dimension data featur select provid optim subset featur data mine model howev current featur select method high dimension data also requir better balanc featur subset qualiti comput cost paper effici hybrid featur select method hfia base artifici immun algorithm optim propos solv featur select problem high dimension data algorithm combin filter algorithm improv clone select algorithm explor featur space high dimension data accord target requir featur select combin biolog research result method introduc lethal mutat mechan cauchi oper improv search perform algorithm moreov adapt adjust factor introduc mutat updat phase algorithm effect combin mechan enabl algorithm obtain better search abil lower comput cost experiment comparison state art featur select method conduct high dimension benchmark dataset result show featur reduct rate dataset perform improv classifi compar five classic filter featur select method comput cost hfia lower two far better five algorithm term featur reduct rate classif accuraci improv compar hybrid featur select method report latest literatur averag win rate term classif accuraci featur reduct rate comput cost respect
|
D000465;D057225
|
T170;T066
|
36,275,945
|
analysi oper factor three pso ga ed meta heurist search method solv singl object optim problem studi evalu sever nongradi evolutionari search strategi minim mathemat function express develop test genet algorithm particl swarm optim differenti evolut order assess general efficaci optim mathemat equat comparison made result effici determin number iter observ accuraci overal run time addit optim employ function easom holder tabl michalewicz ackley rastrigin rosen rosen brock shubert sphere schaffer himmelblau spring forc vanderplaat furthermor crossov rate mutat rate scale factor evalu determin effect follow algorithm accord result comparison optim algorithm de algorithm lowest time complex other furthermor ga demonstr greatest degre tempor complex result use pso method produc differ result repeat algorithm low reliabl term locat optim locat
|
D000066506;D000465
|
T170
|
36,275,907
|
si pdgfr load exosom suppress progress glioma inhibit oxid associ pikaktezh signal pathway studi investig possibl exosom load si pdgfr abil suppress progress glioma common glioma develop neurogli progenitor cell mani variabl affect surviv rate occurr glioma understand oxid stress process creat new effici treatment crucial oxid stress link develop brain tumor purpos select clinic sampl subject various test like quantit real time pcr cignal finder rtk signal pathway report array analysi cck analysi flow cytometri immunoblot demonstr pdgfr express increas glioma patient follow cell deriv exosom extract collect trace vivo select tissu sampl subject immunohistochem analysi result indic knockdown pdgfr si pdgfr inhibit prolifer glioma cell besid si pdgfr load exosom induc similar antitumor effect glioma cell anticanc effect si pdgfr load exosom mediat inactiv pikaktezh pathway final verifi exosom deliveri system si pdgfr load exosom robust target associ toxic conclus studi confirm si pdgfr load exosom inhibit glioma progress via inactiv pikaktezh signal pathway
|
D055354;D005910
|
T026;T191
|
36,275,906
|
fundus vascular respons color deviat caus non oxid blue filter short wavelength blue light damag retina oxid stress retin pigment epitheli rpe cell filter blue light screen could reduc blue hazard wherea inevit alter color gamut coverag color deviat level although abnorm fundus vascular densiti fvd sometim indic fundus diseas research notic respons variat color gamut coverag color deviat level
|
D008027;D018384
|
T049;T070
|
36,275,905
|
epoxyeicosatrieno acid inhibit activ murin fibroblast block tgf smad signal ppar depend manner epoxyeicosatrieno acid eet metabolit arachidon acid cytochrom p cyp report serv vital endogen protect factor sever chronic diseas eet metabol solubl epoxid hydrolas seh observ prophylact block seh allevi bleomycin blm induc pulmonari fibrosi pf mice howev under mechan therapeut effect eet pf remain elus
|
D011658;D053773
|
T123;T047;T121;T116
|
36,275,904
|
transcriptom sequenc analysi lncrna mrna express profil bone nonunion bone nonunion serious complic fractur studi explor differenti express lncrnas del mrnas deg identifi potenti lncrna mrna interact bone nonunion
|
D035683;D062085
|
T123;T114
|
36,275,903
|
role oxid stress retin diseas earli intervent strategi review retina owe cellular anatomi physic locat suscept generat reactiv oxygen speci ros associ sever major retin diseas ros exceed bodi natur antioxid retina state oxid stress recogn pathogenesi retin diseas earli stage pathogen process adapt chang oxid stress endogen defens mechan occur treatment appli retin diseas progress patholog stage neuron vascular dysfunct damag even blind review summar role oxid stress sever common retin diseas includ retin pigmentosa age relat macular degener diabet retinopathi glaucoma retinopathi prematur addit discuss earli intervent strategi diseas outlin provid identifi potenti intervent target research earli intervent retin diseas necessari urgent may offer hope improv patient qualiti life function vision
|
D011788;D012164
|
T078;T047
|
36,275,902
|
glutathion peroxidas predictor diabet kidney diseas progress type diabet mellitus diabet kidney diseas dkd repres heavi burden type diabet mellitus tdm ferroptosi play import role dkd thus provid new perspect pursu relat biomark assess diseas sever prognosi glutathion peroxidas gpx mainstay regul ferroptosi current studi investig predict valu kidney gpx express level dkd progress
|
D003928;D003924;D007676
|
T047
|
36,275,901
|
mechan drug intervent doxorubicin induc cardiotox base mitochondri bioenerget doxorubicin dox anthracyclin chemotherapi drug indispens antitumor therapi howev subsequ induct cardiovascular diseas cvd becom primari caus mortal cancer survivor accumul evid demonstr cardiac mitochondri bioenerget chang becom signific marker doxorubicin induc cardiotox dic main summar relat mechan dox induc cardiac mitochondri bioenerget disord report recent year includ mitochondri substrat metabol mitochondri respiratori chain myocardi atp storag util mechan affect mitochondri bioenerget addit intervent dox induc cardiac mitochondri bioenerget disord use chemic drug tradit herbal medicin also summar provid comprehens process studi develop appropri therapeut strategi dic
|
D066126;D006331
|
T047;T037
|
36,275,900
|
identif mirsnp regulatori axi abdomin aortic aneurysm network pathway base integr analysi abdomin aortic aneurysm aaa refer local abnorm expans abdomin aorta most occur elder men microrna mirna singl strand rna consist nucleotid play key role posttranscript gene express regul human function diseas develop mirna exert function main bind complementari base pair regulatori region mrna transcript therefor mirna relat singl nucleotid polymorph mirsnp affect mirna express process kinet mirsnp classifi base locat mirsnp within mirna produc gene mirsnp within mirna target gene increas evid indic mirsnp play import role pathogen kinet cardiovascular diseas aim studi identifi potenti mirna integr mirsnp base diseas relat pathway network result great signific interpret potenti mechan function mirsnp pathogenesi diseas
|
D017544;D035683
|
T123;T047;T114
|
36,275,899
|
ferroptosi rise forc renal fibrosi ferroptosi type program cell death character iron overload oxid stress imbal lipid repair mitochondria specif patholog manifest grow number molecular mechan signal pathway found involv ferroptosi progress includ iron metabol amino acid metabol lipid metabol energi metabol worth note ferroptosi involv progress fibrot diseas liver cirrhosi cardiomyopathi idiopath pulmonari fibrosi inhibit ferroptosi acquir benefici outcom rodent model studi ferroptosi renal fibrosi remain limit recent studi reveal target ferroptosi effect mitig chronic kidney injuri renal fibrosi moreov myofibroblast suffer ferroptosi fiber extracellular matrix deposit fibrot cascad reaction pharmacolog modul ferroptosi show great therapeut effect renal fibrosi summar latest molecular mechan ferroptosi high qualiti studi review therapeut potenti renal fibrosi
|
D000079403;D007674
|
T047;T043
|
36,275,898
|
gnai risk factor gastric cancer studi tumor microenviron tme establish immun risk score ir although g protein subunit gnai upregul multipl cancer prognost valu exact role develop gastric cancer gc remain larg unknown
|
D013274
|
T191
|
36,275,897
|
sirt prevent glucocorticoid induc osteonecrosi femor head rat glucocorticoid induc osteonecrosi femor head one common caus nontraumat osteonecrosi femor head exact pathogenesi remain unclear aim studi investig role sirt mainten bone tissu morpholog structur intravascular lipid metabol potenti molecular mechan glucocorticoid induc osteonecrosi femor head
|
D010020;D037761
|
T047;T046;T126;T116
|
36,275,896
|
mir p regul gata promot cardiac fibrosi target gpd cardiac fibrosi hallmark numer chronic cardiovascular diseas lead heart failur howev valid therapi dysregul microrna confirm involv cardiac fibrosi develop howev regulatori network well explor studi first highlight role molecular mechan mir p cardiac fibrosi found mir p consist increas three fibrot model includ heart tissu postmyocardi infarct mi mice neonat rat cardiac fibroblast treat angiotensin ii ang ii transform growth factor tgf furthermor myocardi infarct surgeri induc cardiac fibrosi dysfunct attenu system deliveri mir p antagomir notabl transfect mir p mimic promot prolifer cardiac fibroblast fibroblast myofibroblast differenti accompani upregul express cola cola sma contrari mir p inhibitor exhibit opposit effect follow verifi gpd direct target mir p gpd sirna abolish antifibrot effect mir p inhibitor neonat rat cardiac fibroblast suggest mir p promot cardiac fibrosi least partial gpd moreov gata identifi cardiac fibrosi associ upstream posit transcript factor mir p final find suggest modul mir p could potenti therapeut method cardiac fibrosi
|
D035683;D009203
|
T123;T047;T114
|
36,275,895
|
clinic analysi minim invas percutan treatment sever lumbar disc herniat ube two channel endoscopi foramin singl channel endoscopi techniqu surgic treatment herniat tradit open surgeri tradit approach repres oper lamina window excis nucleus pulposus recent year unilater dual channel spine endoscop technolog ubebess caus extens concern spine surgeri perform research compar result minim invas percutan treatment sever lumbar disc herniat foramin singl channel endoscopi unilater biport endoscopi ube retrospect studi conduct patient sever disc herniat treat minim invas percutan treatment mindong hospit affili fujian medic univers septemb septemb accord differ surgic method divid two group foramin singl channel endoscop group ube dual channel endoscop group case ube surgeri group case interforamin endoscop group comparison includ oper time postop hospit stay preoper postop pain scale vas postop mri observ residu condit prolaps nucleus pulposus occurr complic signific differ ube group interforamin endoscop group incis length oper time postop hospit stay improv vas score surgeri term postop nucleus pulposus residu rate postop recurr rate two channel ube group signific better singl channel interforamin endoscop group incid postop anemia interforamin endoscop group signific lower ube group treatment sever disc herniat ube two channel endoscopi advantag lower recurr rate lower nucleus pulposus residu rate shorter learn curv better field vision foramin singl channel endoscopi worth promot primari hospit
|
D007405;D017587
|
T061;T047
|
36,275,894
|
transcript factor p regul mir b weaken cigarett smoke extract induc cellular stress target rhoarock signal previous studi identifi mir b potenti biomark smoker without chronic obstruct pulmonari diseas copd howev function molecular mechan mir b pathogenesi copd remain elus
|
D000073865;D035683;D029424
|
T055;T047;T123;T114
|
36,275,893
|
oncogen immunolog role apoptosi antagonist transcript factor human tumor pan cancer analysi apoptosi antagon transcript factor aatf particip tumor progress multipl cancer type howev role across cancer well understood
|
D002295;D001749
|
T191
|
36,275,892
|
human umbil cord mesenchym stem cell deriv exosom repair endometri epitheli cell injuri induc hypoxia via regul mir acdkna axi thin endometrium remain sever clinic challeng effect therapi date aim explor role molecular mechan human umbil cord mesenchym stem cell hucmsc deriv exosom hucmsc ex repair hypox injuri endometri epitheli cell eec
|
D055354;D059630;D035683
|
T026;T123;T025;T114
|
36,275,891
|
carbomethoxyl epigyrosanoldi e extract cultur soft coral sinularia sandensi induc apoptosi autophagi via ros mitochondri dysfunct er stress oral cancer cell oral cancer malign neoplasia common asian region men higher risk women current clinic treatment oral cancer consist radiat therapi combin chemotherapi therefor import find drug inhibit growth cancer cell effect safe studi examin cytotox carbomethoxyl epigyrosanoldi e extract cultur soft coral sinularia sandensi toward oral cancer cell mtt cell prolifer coloni format assay use evalu cell surviv immunofluoresc stain western blot employ analyz effect carbomethoxyl epigyrosanoldi e apoptosi autophagi carbomethoxyl epigyrosanoldi e treatment also induc format reactiv oxygen speci ros associ carbomethoxyl epigyrosanoldi e induc cell death addit carbomethoxyl epigyrosanoldi e induc antiprolifer effect ca cal cell associ releas cytochrom c mitochondria activ proapoptot protein caspas bax bad inhibit antiapoptot protein bcl bcl xl mcl carbomethoxyl epigyrosanoldi e treatment also trigger endoplasm reticulum er stress lead activ perkelf atfchop apoptot pathway moreov increas express beclin atg atg atg atg atg lc lc ii protein indic carbomethoxyl epigyrosanoldi e trigger autophagi oral cancer cell conclus find demonstr carbomethoxyl epigyrosanoldi e suppress human oral cancer cell prolifer investig regard potenti use chemotherapi drug treatment human oral cancer
|
D037421;D009062
|
T191;T204
|
36,275,890
|
mir p deliv use exosom attenu keratinocyt respons il stimul psoriasi nhek hacat cell hek cell treat il cck assay perform detect cell activ immunofluoresc stain western blot perform detect protein express stat isol exosom via ultracentrifug content mir p oxid stress marker superoxid dismutas sod malondialdehyd mda glutathion peroxidas gsh px keratinocyt measur subsequ transcriptom analysi perform use rna seq data analys use edger packag within r verifi abnorm express gene stimul il dual luciferas report assay use determin interact mir p stat final balbc mice use establish psoriasi model analysi effect elev mir p psoriasi mous model determin exosom deliveri mir p
|
D055354;D011565;D035683
|
T026;T123;T047;T114
|
36,275,885
|
studi influenc urban built environ factor social behavior asd children use urban space vulner group especi asd children social anxieti import part build sustain urban develop studi focus play behavior asd children perspect urban plan discuss urban built environment factor affect social behavior asd children paper parent asd children given questionnair valid questionnair obtain remov invalid one stepwis regress adopt accur analyz influenc factor index built environ children social behavior result show multipl urban built environ factor signific influenc social behavior observ particip retreat conceal children autism three stage departur journey arriv destin purpos studi fulli consid use urban space asd children urban research urban planner construct sustain urban form formul urban design guidelin implement old citi renew strategi
|
D000067877
|
T048
|
36,275,884
|
artifici intellig technolog driven environment factor extract analysi method tradit cloth handicraft applic artifici intellig ai technolog field cloth provid good develop mode system social context ai technolog develop ai provid help develop intellig cloth intellig cloth high tech product integr intellig technolog cloth combin cut edg technolog electron inform technolog sensor technolog textil scienc materi scienc extract analysi environment factor cloth handicraft ai technolog consider applic prospect certain develop potenti order improv accuraci environment factor extract cloth handicraft paper use convolut neural network cnn extract analyz environment factor tradit cloth handicraft carri experi extract environment factor cloth handicraft pure color pattern pattern complex background experiment result show cnn good effect extract environment factor cloth handicraft differ background addit model paper good stabil accuraci featur extract speed high practic valu research signific
|
D001185;D016571
|
T090;T170;T073;T066
|
36,275,883
|
evalu method comprehens qualiti environment protect teacher base big data analysi technolog order improv shortcom weight index easili affect human influenc evalu tradit teacher comprehens literaci basi analysi index coeffici featur reorgan featur analysi paper construct comprehens literaci environment protect profession teacher educ big data environ evalu model propos weight distribut scheme teacher comprehens literaci evalu indic propos base hierarch bayesian beta return model improv ration indic distribut make predict result accur simul result verifi superior propos model improv comprehens qualiti evalu level environment protect teacher
|
D000070777;D000078332
|
T097;T057
|
36,275,882
|
analysi ecolog environ problem countermeasur ideolog polit educ colleg univers present mani problem mode method ideolog emot educ colleg student state attach great import aspect continu increas invest effect satisfactori import field cultiv high level socialist talent colleg univers play huge role promot ideolog develop emot educ colleg student emerg contradict show tradit educ method shortcom need expand think explor new research area sinc new era ideolog educ venu teach activ colleg univers great improv also face mani problem challeng serious affect moral qualiti colleg student destroy ideolog educ ecosystem colleg univers perspect ecolog crisi educ paper awaken pay attent ecolog problem educ make inevit trend current educ develop pave way futur research basi current situat ecolog polit educ colleg student analyz necess research propos analyz ideolog emot educ colleg student perspect ecolog essenti regard ideolog educ colleg student ecosystem deepli analyz distribut various compon element colleg student ideolog polit educ ecolog colleg student ideolog educ process law overal ecolog balanc various factor ideolog educ system colleg student well methodolog think valu orient interact various factor environ chang ecolog environ signific impact peopl state mind colleg student grow new environ thought emot valu affect develop ecolog environ therefor chang ecolog environ air qualiti water environ increas obvious impact live environ
|
D017753;D013334
|
T098;T081;T070;T082
|
36,275,881
|
risk factor affect infus rate chemotherapeut agent within hour prepar intervent effect qualiti control circl investig risk factor infus rate chemotherapeut agent within hour prepar observ applic effect qualiti control circl
|
D006761
|
T073;T093
|
36,275,880
|
incom inequ harm green growth bric experi green growth play vital role ensur sustain develop manag econom growth without disrupt environ consid need present time therefor empir turn attent toward find determin green growth henc aim investig impact incom inequ green growth bric economi find panel autoregress distribut lag ardl model confirm long run estim attach gini negat signific impli higher inequ bric economi lower rate green growth countri wise result highlight negat impact gini green growth india china insignific countri short run estim inconclus mix group wise individu estim find impli target lower inequ environment sustain achiev simultan
|
D002245;D057217
|
T081;T123;T197
|
36,275,879
|
applic public art design base digit technolog urban landscap environment monitor public art pa power tool enhanc environ public space sinc reliev oppress caus urban architectur also enhanc beautifi urban public space dt digit technolog develop quick nowaday offer pa signific technolog assist achiev new function chang modern peopl aesthet prefer psycholog makeup also present new demand pa essay explor use pa design creation urban landscap viewpoint dt order paper suggest method measur environment impact urban landscap combin landscap measur semant assess full connect algorithm greedi algorithm introduc identifi urban function type high dimension characterist boundari tree classif model high dimension featur classif find indic public servic area produc user accuraci respect offer fresh concept identif urban function zone solv issu low identif effici poor accuraci
|
D000082222;D004784
|
T090;T073;T057
|
36,275,862
|
fulli murin cd target car cell provid immunocompet model car cell biolog model chimer antigen receptor car cell therapi most focus immunodefici model howev mani advantag studi car cell biolog immunocompet set generat fulli murin car target cd endoglin compon tgf receptor express surfac certain solid tumor acut leukemia cd target car cell grown various murin background track vivo congen mark activ cd isol express tumor cell cd target car cell toxic higher dose prove safe lower dose modest effect treat wild type b melanoma bear mice car cell infiltr tumor express high level exhaust marker exhibit metabol insuffici also generat human cd car efficaci treat human melanoma acut myeloid leukemia vivo work detail new murin model car cell therapi use immunologist understand car cell biolog also set foundat explor cd possibl human car cell target
|
D015470;D000076962
|
T129;T191;T116;T192
|
36,275,847
|
gaba signal focal epileptiform synchron epileptogenesi physiolog condit neuron network synchron lead differ oscillatori eeg pattern associ specif behavior cognit function excess synchron howev lead focal general epileptiform activ inde well establish epilept patient anim model focal epileptiform eeg pattern character interict ictal seizur discharg last three decad employ vitro vivo record techniqu sever experiment studi firm identifi paradox role gaba signal generat interict discharg initi perhap sustain focal seizur review experi extend apprais evid suggest gaba signal may also contribut epileptogenesi ie develop plastic chang brain excit lead chronic epilept condit overal anticip inform provid rational develop new specif pharmacolog treatment patient present focal epilept disord mesial tempor lobe epilepsi mtle
|
D004833;D004828;D004827
|
T033;T047
|
36,275,845
|
analysi herdsmen credit behavior identif scheme emot psycholog state herdsmen access credit fund play import support role promot modern econom develop pastor area broaden channel herder increas incom paper studi credit behavior herdsmen perspect emot psycholog state identif analyz current credit behavior herdsmen first intern mechan herdsmen credit emot psycholog identif research content analyz second scheme emot psycholog state identif propos correspond survey herdsmen carri accord scheme final probit heckman model introduc analyz credit behavior herdsmen result show herdsmen high emot psycholog score strong demand credit like access credit high level credit herdsmen low score emot psycholog characterist low appar demand credit credit avail also low herdsmen high emot psycholog characterist higher probabl generat credit demand herdsmen low open likelihood obtain credit also higher herdsmen low emot psycholog characterist also easi access higher loan amount result provid refer relat research analysi herdsman credit behavior econom develop
|
D009788
|
T061
|
36,275,844
|
factor analysi mental health prevent employe turnov profit center develop modern servic industri recent employe turnov rate modern servic industri continu increas lead declin servic qualiti custom turnov increas human cost meanwhil fierc competit enterpris intern pressur brought great psycholog trauma employe affect mental health understand find factor affect employe resign solut employe mental health problem research innov lie build relationship model turnov intent psycholog contract job satisfact analyz influenc mechan interact various variabl model provid refer think servic industri solv problem excess turnov employe besid questionnair design investig carri front line employe servic compani select research object result show overal intern consist coeffici scl overal consist coeffici direct proport scale reliabl valid coeffici scl good compat valid moreov correl coeffici psycholog contract turnov intent sig valu correl coeffici job satisfact turnov intent sig valu psycholog contract posit correl turnov intent job satisfact negat correl turnov intent standard danc experi p valu psycholog indic somat interperson relationship depress anxieti psychosi factor employe control experiment group less indic signific correl therefor week standard danc practic psycholog indic experiment group signific improv howev chang result terror factor paranoia factor p show signific differ standard danc experi signific differ control experiment group mental health factor signific differ terror paranoia factor studi signific refer valu prevent employe turnov mental health
|
D010563;D009788
|
T081;T061
|
36,275,778
|
induc general knockout runx profound reduc pulmonari cytotox cd cell minim effect outcom mice follow influenza infect respiratori virus pose continu substant threat human health global host innat adapt immun respons critic antivir defens mechan control viral replic spread present studi design determin role transcript factor runx host immun respons influenza virus iav infect runx requir embryon develop generat induc runx global knockout ko mous model found runx ko adult cbl mice minim affect thymic function normal condit surviv least day post runx delet appli mous model iav infect found runx ko result huge reduct number total antigen specif pulmonari cd cytotox cell iav infect minor effect pulmonari generat cd cell surpris general ko runx signific alter viral clearanc anim surviv follow iav infect interest found runx ko signific increas number pulmonari innat immun cell macrophag neutrophil product pro inflammatori cytokin iav infect found runx strong detect ccr immun cell iav infect mous lung induc activ macrophag dendrit cell dcs pulmonari cd cytotox cell play central role clearanc iav find suggest runx ko may enhanc host innat immun compens loss pulmonari cd cytotox cell iav infect
|
D009980;D007251;D009976
|
T005;T047
|
36,275,777
|
efficaci safeti univers tcrko ari car cell treatment b cell lymphoma autolog cell express chimer antigen receptor car approv advanc therapi medicin product atmp sever hematolog malign howev generat patient specif car product delay treatment preclud standard allogen shelf car cell altern simplifi complex time consum process investig safeti efficaci knock tcr molecul ari car cell second generat cd car approv spanish agenc medicin medic devic aemp hospit exempt treatment patient older year relapsedrefractori acut b cell lymphoblast leukemia b first analyz efficaci safeti issu aris disrupt tcr gene use crisprca shown edit trac locus cell use crispr ribonuleorprotein allow high effici tcr disrupt without signific alter cell phenotyp increas percentag energet mitochondria howev also found effici tcrko lead target larg medium size delet indic potenti safeti risk procedur need monitor import tcr edit ari effici prevent allogen respons detect alter phenotyp maintain similar anti tumor activ ex vivo vivo compar unedit ari car cell summari show although still risk genotox due genom edit disrupt tcr feasibl strategi generat function allogen ari car cell propos valid protocol treatment patient fit requir standard autolog car cell administr
|
D000076962;D054198;D016393
|
T129;T191;T116;T192
|
36,275,776
|
target cell oxid metabol improv immun viral infect context obes disord system metabol influenc immun individu obes known increas inflamm increas risk select autoimmun diseas impair respons sever infect impair vaccin respons exampl last decad becom clear individu obes increas risk morbid mortal influenza infect unsurpris find also observ current covid pandem individu obes particular sever obes increas risk poor outcom sar cov infect includ increas rate hospit icu admiss mechan ventil death sever studi demonstr critic role cell context obes associ immun dysfunct respons viral infect one mechan may alter cell metabol inde recent studi shown activ cell obes mice alter metabol profil character increas glucos oxid vitro vivo follow viral infect reason treatment target abnorm immun cell metabol obes may improv outcom viral infect end sever recent studi shown use metabol drug metformin revers abnorm cell metabol restor cell immun well surviv respons viral infect find discuss detail
|
D000086382;D008687
|
T121;T047;T067;T109
|
36,275,775
|
senesc associ secretori phenotyp impact oral immun homeostasi senesc associ secretori phenotyp sasp accumul cours normal age age relat diseas crucial driver chronic inflamm age phenotyp also respons pathogenesi multipl oral diseas howev pathogen mechan under sasp yet fulli elucid relev articl sasp publish last five year retriev use bibliometr analysi first time examin sasp composit half relev articl focus various cytokin growth factor proteas addit lipid metabolit extracellular vesicl receiv increas attent past five year recogn novel sasp categori base summar evid demonstr sasp play pleiotrop role oral immun propos four step hypothet framework progress sasp relat oral patholog oral sasp develop sasp relat oral patholog alter patholog chang lead oral immun homeostasi disrupt sasp mediat immun dysregul escal oral diseas target specif sasp factor potenti therapi develop treat oral age relat diseas
|
D016922;D000089262
|
T043
|
36,275,774
|
novel hypoxia lactat metabol relat signatur predict prognosi immunotherapi respons breast cancer integr machin learn bioinformat analys breast cancer common cancer worldwid hypoxia lactat metabol hallmark cancer studi aim construct novel hypoxia lactat metabol relat gene signatur predict surviv immun microenviron treatment respons breast cancer patient
|
D001943
|
T191
|
36,275,773
|
four clinic phenotyp cow milk protein allergi base dairi product specif ige antibodi type north china cow milk protein allergi cmpa common allergi immunoglobulin e ige mediat cow milk allergi associ high mortal risk poor prognosi studi aim investig whether differ clinic cmpa phenotyp china explor associ cmpa phenotyp specif ige sige antibodi differ dairi product
|
D016269
|
T046
|
36,275,772
|
random doubl blind placebo control dose escal phase trial evalu safeti immunogen plant produc bival recombin norovirus like particl vaccin norovirus nov lead caus epidem acut gastroenter human worldwid safe effect vaccin need phase doubl blind placebo control clinic trial perform healthi adult year old safeti primari object immunogen secondari exploratori object bival gi gii plant produc virus like particl vlp nov vaccin candid formul investig two dose level g g g g without adjuv overal subject g group subject g group subject placebo group report least solicit local general symptom day post vaccin period follow dose sever solicit advers event ae rare event g group total subject group report least one unsolicit ae day post vaccin period immunogen assess day subject pre expos norovirus indic baselin level differ immunolog paramet examin vaccin specif humor cellular immun respons increas first dose rise second vaccin increas gi gii specif igg titer persist day vaccin elicit cross reactiv igg antibodi non vaccin nov vlps pronounc nov strain genotyp gii vaccin strain non vaccin genotyp signific block anti gi anti gii vlp titer trigger dose group lymphoprolifer assay reveal strong cell mediat immun respons persist day conclus dose level safe well toler higher incid ae observ higher dose group data show singl dose vaccin formul g vlp suffici reach peak immun respons day result phase studi warrant evalu non adjuv vaccin candid
|
D029322;D017250;D014765;D005759
|
T129;T005;T121;T047
|
36,275,771
|
progress histolog lesion abo incompat kidney transplant recent larg meta analys suggest poorer long term patient graft outcom abo incompat aboi live donor kidney transplant ldkt compar abo compat ldkt howev littl known long term histolog pattern aboi ldkt compar histolog featur observ protocol biopsi aboi ldkt includ preform donor specif antibodi pdsas ldkt abo compat aboc pdsas aboc without pdsas first five year post transplant first year post transplant progress chronic lesion patient ci rais p rais p observ aboi ldkt without pdsas histolog pattern evolut compar observ aboc kidney transplant patient microvascular inflamm lower aboi ldkt without pdsas compar pdsas aboi aboc last follow month iqr post transplant patient sever graft dysfunct defin ckd epi egfr mlminm donor age predict factor develop sever kidney allograft dysfunct last follow hr ci p henc long term histolog analysi aboi ldkt show increas chronic interstiti tubular atrophi chang without activ lesion data confirm aboi ldkt program secur develop
|
D016030;D000744
|
T061;T047
|
36,275,770
|
immunotherapi improv diseas prognosi affect tumor microenviron bibliometr studi immunotherapi shown great potenti treatment multipl cancer proven close relat tumor microenviron articl reveal collabor interact among author nation organ period assess knowledg base discov hot tendenc new topic associ immunotherapi tumor microenviron tme research
|
D015706;D009369
|
T062;T191
|
36,275,769
|
immunoproteasom control activ innat immun signal microgli function microglia resid immun cell central nervous system cns play major role regul brain homeostasi maintain cellular protein homeostasi microglia express standard proteasom immunoproteasom ip proteasom isoform preserv protein homeostasi also non immun cell challeng condit impact ip microglia function innat immun cns howev well describ establish ip impair lead proteotox stress trigger unfold integr stress respons mous human microglia model use proteom analysi demonstr ip defici microglia result profound alter ubiquitin modifi proteom among protein involv regul stress immun respons line molecular analysi reveal chronic activ nf b signal ip defici microglia without stimulus addit show ip impair alter microgli function base marker phagocytosi motil molecular level ip impair activ interferon signal promot activ cytosol stress respons protein kinas r present data highlight import ip function proteostat potenti well precis proteolysi control stress immun signal microglia function
|
D017628;D016328
|
T129;T116;T025
|
36,275,768
|
resolvin show osseous protect via rank reduct monocyt orthodont tooth movement studi aim investig role rvd acut prolong steril inflamm bone remodel mous model steril inflamm involv bone resorpt use examin endogen rvd kinet inflamm applic exogen rvd signific inhibit bone remodel via osteoclast reduct alongsid anti inflammatori secretom shift increas macrophag recruit reduct cytotox cell vitro vivo rvd led signific reduct rank express reduc osteoclastogenesi dose depend manner taken togeth data show dual role rvd potent immunoresolv agent alongsid osteoresolv role show potenti therapeut agent bone resorpt associ inflammatori condit
|
D009000;D001862
|
T025;T042
|
36,275,767
|
puls radiotherapi mitig high tumor burden generat immun memori radiat therapi xrt well establish role cancer treatment given encourag result immunostimulatori effect radiat increas use immun check point inhibitor metastat diseas especi immunotherapi fail due tumor immun evas hypothes use high dose stereotact radiat cycl puls would increas cell prime repertoir puls build immun memori increment manner prove hypothesi studi combin anti ctla puls radiat therapi sq non small cell lung adenocarcinoma murin model primari secondari tumor bilater implant svev mice puls xrt group primari secondari tumor receiv gyx radiat one week apart blood collect seven day afterward tcr repertoir analysi delay puls group primari tumor receiv gyx window two week secondari tumor receiv gyx blood collect seven day second cycl radiat immunotherapi backbon group anti ctla antibodi help prime treatment puls xrt anti ctla led signific improv surviv result delay tumor growth observ enhanc antitumor efficaci primari tumor site beyond xrt anti ctla treatment group import puls xrt treatment led increas cd effector memori compar singl cycl xrt puls xrt demonstr superior efficaci xrt drive antitumor effect larg depend cd cell partial depend cd cell result suggest combinatori strategi target multipl point tumor immun evas may lead robust sustain antitumor respons
|
D018414;D000230
|
T191;T025
|
36,275,766
|
immunotherapi cater unmet medic need cold colorect cancer common malign tumor gastrointestin tract incid colorect cancer crc gradual increas recent year western develop countri even becom second largest malign tumor next lung cancer immunotherapi hot topic field cancer therapi includ immun checkpoint blockad icb adopt cell therapi act cancer vaccin cytokin aim improv abil immun system recogn target elimin cancer cell howev cold crc account high proport crc reactiv develop immunotherapi prevent cancer cell form immun escap pathway immun system cold crc increas studi attent proof organ combin radiotherapi chemotherapi sever immunotherapi consider boost immun system capac erad tumor cell review summar role immunotherapi colorect cancer addit propos breakthrough strategi improv role immunotherapi cold crc base characterist
|
D019496;D015179
|
T129;T121;T191;T116
|
36,275,765
|
monocyt deriv periton macrophag protect cbl mice surgeri induc adhes periton adhes common occur abdomin pelvic surgeri scar join intern organ caviti wall present abdomin pelvic pain bowel obstruct femal infertil mechan under adhes format remain unclear thus effect treatment forthcom periton macrophag accumul surgeri previous studi attribut either pro anti scar properti cell propos complex nuanc respons surgeri respect resid also monocyt deriv periton macrophag subpopul moreov contend differ respons specif macrophag subpopul part explain risk develop periton scar character alter periton macrophag subpopul surgeri induc injuri use two strain mice balbc cbl known differ macrophag respons post infect day post surgeri balbc mice display adhes compar cbl mice increas scar correl lower influx monocyt deriv macrophag day post surgeri moreov balbc mice show distinct macrophag repopul dynam surgeri confirm role monocyt deriv macrophag use ccr defici mice well antibodi mediat deplet ccr express cell initi stage adhes format ccr defici ccr deplet mice show signific increas adhes format associ loss periton monocyt influx find reveal import protect role monocyt deriv cell reduc adhes format surgeri
|
D009000;D017737
|
T025
|
36,275,764
|
compar analysi repertoir insulin reactiv b cell type diabet prone resist mice seroposit autoantibodi multipl islet antigen associ develop autoimmun type diabet td suggest role b cell diseas import b cell td indic effect b cell therapi mous model patient b cell contribut td present islet antigen includ insulin diabetogen cell kill pancreat beta cell role b cell receptor bcr affin td develop unclear employ singl cell rna sequenc defin relationship bcr affin insulin b cell phenotyp diseas develop util immunoglobulin ig heavi chain vh mous model high affin insulin reactiv b cell ibc previous shown anerg diabet resist vhcbl hg activ vh nod mice develop diseas high affin ibc found spleen prediabet vh nod mice exhibit margin zone follicular phenotyp ig light chain express b cell unmut bias toward v v usag receptor express anerg high affin ibc diabet resist vhcbl hg also unmut howev genet background light chain polymorph relat nod light chain deriv nod cbl hg genet background confer diverg kinet bind insulin pair vh heavi chain find suggest relax toler mechan nod mous lead accumul partial activ b cell express germlin encod high affin bcrs support develop autoimmun
|
D003922
|
T047
|
36,275,763
|
case report para infecti cranial nerv palsi bacteri mening year old woman admit hospit fever associ headach nausea vomit rapid develop mild left facial nerv palsi diplopia neurolog examin reveal mild mening associ bilater vi cranial nerv palsi mild left facial palsi central nervous system cns infect suspect diagnost lumbar punctur perform reveal cellsl polymorphonuclear leukocyt moreov multiplex pcr immunoassay posit neisseria meningitidi support diagnosi bacteri mening final igg oligoclon band iggob absent serum cerebrospin fluid csf therefor ceftriaxon antibiot therapi start follow day patient sign symptom improv complet remiss diplopia mening sign within week contrari left facial nerv palsi progress worsen sever bilater deficit second lumbar punctur therefor perform csf analysi reveal remark decreas pleocytosi qualit modif lymphocyt oligoclon igg band present new brain mri perform show bilater gadolinium enhanc intrameat vii viii cranial nerv bilater due suspicion para infecti etiolog patient treat oral steroid prednisolon mgkgday progress complet regress symptom suggest case pathogen driven immunolog respons character relev csf mix pleocytosi evid iggob para infecti adapt immun driven reaction mild lymphocyt pleocytosi pattern iii iggob vii viii cranial nerv start inde steroid administr caus rapid complet restor cranial nerv function
|
D003389;D016920
|
T047
|
36,275,762
|
detect bk polyomavirus associ nephropathi use plasma graft deriv cell free dna develop novel algorithm program monitor graft deriv cell free dna gcfdna promis non invas biomark detect allograft injuri studi aim evalu efficaci program monitor gcfdna identifi bk polyomavirus associ nephropathi bkpyvan kidney transplant recipi recruit kidney transplant recipi novemb decemb plasma gcfdna collect tenth day first month third month sixth month program monitor one day biopsi gcfdna cpml obtain subtract baselin gcfdna cpml gcfdna cpml latest program monitor biopsi receiv oper characterist curv show diagnost perform gcfdna cpml biopsi time optim area curv auc distinguish patholog proven bkpyvan patholog unconfirm bkpyvan contrast gcfdna cpml sensit specif respect auc distinguish clinic diagnos bkpyvan clinic exclud bkpyvan auc gcfdna cpml biopsi time gcfdna cpml sensit specif respect auc plasma gcfdna cpml signific differ tcmr cpml patholog proven bkpyvan cpml conclus recommend program monitor plasma gcfdna level kidney transplant base find program monitor develop novel algorithm show promis result identifi predict bkpyvan
|
D001739;D014412;D027601;D009395;D000073888
|
T123;T191;T005;T114;T047
|
36,275,761
|
sustain surveil intervent covid pandem cabo verd implic malaria elimin cabo verd report first case covid march contain measur quick implement covid test perform confirm infect popul death set last local acquir malaria case report januari interrupt malaria care seek potenti infect go untreat transmiss establish work aim determin whether chang number peopl seek care test malaria use interrupt time seri analysi identifi chang associ implement covid measur routin collect surveil data outpati visit test malaria covid aggreg month health facil outpati malaria municip covid timelin covid measur generat base implement result show mark shift care seek cabo verd overal mean number observ outpati visit decreas visit per month estim reduct howev malaria test rate per outpati visit pandem began increas compar expect trend result suggest pandem impact care seek led non signific increas test malaria per outpati visit cessat intern travel risk import infect seed new transmiss declin suggest risk undetect transmiss low import countri understand specif malaria risk vulner order ensur progress toward interrupt malaria transmiss sustain
|
D000086382;D008288
|
T047;T067
|
36,275,760
|
buprenorphin revers neurocognit impair ecohiv infect mice potenti therapi hiv nci thirti eight million peopl worldwid live hiv pwh major public health problem antiretrovir therapi art revolution hiv treatment signific increas lifespan pwh howev approxim pwh develop hiv associ neurocognit disord hiv nci spectrum cognit deficit negat impact qualiti life mani pwh also opioid use disord oud studi anim model hiv infect well pwh suggest oud contribut hiv nci synthet opioid agonist buprenorphin treat oud effect hiv nci unclear report human matur inflammatori monocyt express opioid receptor mor kor buprenorphin reduc import step monocyt transmigr monocyt also serv hiv reservoir despit effect art enter brain contribut hiv brain diseas use ecohiv infect mice establish model hiv infect hiv nci previous show pretreat mice prior ecohiv infect reduc mous monocyt entri brain prevent nci show buprenorphin treatment ecohiv infect mice alreadi establish chronic nci complet revers diseas diseas revers associ signific reduct brain inflammatori monocyt revers dendrit injuri cortex hippocampus result suggest hiv nci persist may requir continu influx inflammatori monocyt brain thus recommend buprenorphin potenti therapi mitig hiv brain diseas pwh without oud
|
D002047;D015658;D009293;D001927
|
T121;T047;T048;T109
|
36,275,759
|
two novel mollusk short form apec contain protein act pattern recognit protein peptidoglycan apextrin c termin apec domain new protein domain larg specif aquat invertebr amphioxus short form apec contain protein acp famili capabl bind peptidoglycan pgn agglutin bacteria via apec domain howev function apec phyla remain unknown examin acp gastropod bivalv first second biggest mollusk class classifi nine group base phylogenet architectur includ three group short form acp one group apextrin two group acp complex architectur group ortholog phyla four group member gastropod bivalv suggest mollusk acp high diversifi select one bivalv acp cgacp oyster crossostrea giga one gastropod acp bgacp snail biomphalaria glabrata function experi high express secret short form acp henc compar amphioxus acp previous report found recombin cgacp bgacp bound yeast sever bacteria differ affin also agglutin microb show inhibit kill effect analys show acp high affin lys type pgn aureus weak affin dap type pgn bacillus subtili recombin acp display weak affin microbi cell wall compon includ lipopolysaccharid lps lipoteicho acid lta zymosan chitin chitosan cellulos well sever pgn moieti includ muramyl dipeptid mdp n acetylglucosamin glcnac n acetylmuram acid murnac besid cgacp highest express gill could great regul quick bacteri challeng reminisc amphioxus acp serv essenti mucus lectin gill taken togeth current find mollusk amphioxus acp suggest sever basic common trait apec domain includ high affin lys type pgn bacteri bind agglutin capac role mucus protein protect mucos surfac
|
D048271;D064175
|
T121;T008;T204;T109
|
36,275,758
|
immun inflammatori mechan abdomin aortic aneurysm abdomin aortic aneurysm aaa life threaten cardiovascular diseas immun mediat infiltr destruct aortic wall aaa develop play signific role pathogenesi diseas various immun cell found aaa mechan activ function still far understood better understand mechan regul develop aberr immun cell activ aaa essenti develop novel prevent therapeut approach review summar current knowledg role immun cell aaa discuss pathogen immun cell activ regul diseas
|
D017544
|
T047
|
36,275,757
|
inflammatori profil convalesc plasma treat covid impact amotosalenuva pathogen reduct technolog blood product therapeut transfus common acknowledg contain biolog activ constitu process prepar midst worldwid covid pandem preliminari evid suggest convalesc plasma may lessen sever covid administ earli diseas particular patient profound b cell lymphopenia prolong covid symptom studi examin influenc photochem pathogen reduct treatment prt use amotosalen hcl uva light comparison untreat control convalesc plasma n pair sampl cffp regard solubl inflammatori factor scdl ifn alpha ifn beta ifn gamma il beta il il il il tnf alpha ex vivo inflammatori bioactiv endotheli cell nt observ signific modul major inflammatori solubl factor molecul test pre post prt note il concentr signific decreas cffp prt wherea il concentr increas prt contrast endotheli cell releas il similar whether cffp pre treat without prt express cd cd presenc cffp similar control level signific decreas cffp pre treat prt interest continu investig il il physiopatholog effect prt treat convalesc plasma clinic trial overal appear cffp post prt excess pro inflammatori research includ care clinic evalu ccp treat patient requir thorough defin clinic relev find
|
D000086382;D058873
|
T047;T067
|
36,275,756
|
identif six gene prognost signatur bladder cancer associ macrophag major compon tumor microenviron tme tumor associ macrophag tam play exceed complic role tumor progress tumorigenesi howev studi report specif tam gene signatur bladder cancer herein studi focus develop tam relat prognost model bladder cancer patient base cancer genom atlas tcga data weight gene co express network analysi wgcna use identifi key gene relat tam macrophag gene ontolog go enrich kyoto encyclopedia gene genom kegg signal pathway analysi show function categori key gene simultan use least absolut shrinkag select oper lasso univari multivari cox regress establish tma relat prognost model contain six key gene tbxas gypc hpgds gab adora folr subsequ singl cell sequenc data download gene express omnibus geo suggest six gene prognost model express tam specif may involv tam polar summari research uncov six tam relat gene may effect risk stratif bladder cancer patient could regard potenti tam relat biomark
|
D001749;D058976
|
T129;T191;T116
|
36,275,755
|
il il pivot cytokin delay wound heal aureus p aeruginosa infect skin although presenc pathogen skin wound known delay wound heal process mechan under delay remain poor understood present studi investig regulatori role proinflammatori cytokin heal kinet infect wound
|
D011550;D055624
|
T007
|
36,275,754
|
integr machin learn method identifi fndcb potenti prognost biomark correl immun infiltr glioma recent discoveri reveal fibronectin type iii domain contain b fndcb act oncogen various cancer howev role glioma remain unclear
|
D001932;D005910
|
T191
|
36,275,753
|
immun infiltr landscap prognosi therapeut respons relev epigenet transcriptom mechan lung adenocarcinoma lung adenocarcinoma luad preval lung cancer subtyp immun infiltr featur comprehens understood address issu present studi initi describ immun infiltr across luad cellular composit function mechan perspect
|
D000077192;D008175
|
T191
|
36,275,752
|
th cell primari sjgren syndrom negat correl increas roseburia coprococcus dysbiosi gut microbiota close relat chronic system inflamm autoimmun play essenti role pathogenesi primari sjgren syndrom pss abnorm proport blood lymphocyt subtyp thtreg detect pss patient aim determin associ gut microbiota thtreg pss
|
D058504;D012859
|
T047;T025
|
36,275,751
|
novel medic decis gene signatur predict respons individu therapi prognosi outcom hepatocellular carcinoma patient molecular target therapi shown potenti hepatocellular carcinoma hcc patient immunotherapi applic develop rapid howev clinic guidanc make individu therapi decis hcc patient remain lack mdh medic decis hcc gene signatur compris gene screen use transcriptom data multikinas inhibitor tki resist hcc cell hcc patient deriv xenograft model pdx model four mdh subtyp distinct biolog clinic characterist defin unsupervis cluster analysi hcc data cancer genom atlas tcga databas facilit individu reason clinic guidanc hcc patient construct mdh score comprehens analysi suggest high mdh score associ tki resist high proport stromal cell infiltr poor surviv outcom recommend concomit stromal activ intervent immunotherapi type hcc moreov low mdh score indic tki sensit combin target immunotherapi recommend nomogram construct iter least absolut shrinkag select oper lasso cox regress analysi success predict year surviv outcom mortal risk hcc patient conclus tki resist model base mdh gene signatur provid novel insight potenti mechan drug resist heterogen hcc integr analysi plus simplifi decis model may aid person treatment prognost assess among hcc patient
|
D006528;D008113
|
T191
|
36,275,750
|
immun checkpoint inhibitor mediat immunosuppress cancer associ fibroblast comprehens review tumor microenviron tme signific contributor cancer progress contain complex connect cellular chemic compon provid suitabl substrat tumor growth develop grow evid show target tumor cell ignor surround tme effect enough overcom cancer diseas fibroblast essenti sentinel stroma due certain condit tme oxid stress local hypoxia becom activ play promin role physic support tumor cell enhanc tumorigenesi activ fibroblast tme defin cancer associ fibroblast caf play crucial role regul biolog behavior tumor tumor metastasi drug resist caf high heterogen popul differ origin addit role support stromal cell multipl immunosuppress function via membran secretori pattern secret differ cytokineschemokin interact mediat recruit regulatori immun cell reprogram immunosuppress function immatur myeloid cell exampl caf contribut immun escap tumor various direct indirect mechan specif immun cell popul moreov caf direct abolish role cytotox lymphocyt activ overexpress inhibitori immun checkpoint iicp ligand tme compart one main regulatori mechan inactiv tumor infiltr lymphocyt cancer lesion caf also essenti player induct express iicp suppress immun respons tme base avail studi caf subset could modul immun cell function tme iicp two way direct express iicp activ caf indirect induct product solubl upregul iicp tme focus caf direct indirect role induct iicp tme well use immunotherapi diagnost present evolv understand immunosuppress mechan caf tme review understand complet pictur caf help develop new strategi improv precis cancer therapi
|
D000072645;D009369
|
T191;T025
|
36,275,749
|
systemat pattern analys v tcrs reveal share public v cell clone consequ rearrang bias higher expans status vv cell major innat cell subset human peripher blood v vdj rearrang short simpl fetal thymus gradual increas divers cdr length along develop call public version v tcrs share among individu age howev unclear whether frequent occur public vv cell clone deriv fetal thymus whether fitter prolifer persist infrequ privat clone
|
D016692;D000075942
|
T129;T116;T025;T192
|
36,275,748
|
durabl respons program cell death blockad multidrug resist recurr ovarian cancer patient hla b supertyp case report relapsedrefractori ovarian cancer especi platinum resist recurr remain major therapeut challeng present case patient recurr ovarian clear cell carcinoma occc fail respond multilin chemotherapi target therapi achiev immun complet respons icr program cell death pd inhibitor treatment overal surviv os month recurr free surviv rfs month immunotherapi count meantim molecular test result reveal tradit biomark immunotherapi includ pd l express microsatellit instabl msi tumor mutat burden tmb negat hla b b supertyp confirm sequenc base hla type case rais possibl ovarian cancer patient multidrug resist may still benefit pd inhibitor therapi even pd l patholog negat
|
D000074322;D010051
|
T129;T121;T191;T116
|
36,275,747
|
bridg gut joint axi gut microbi metabolit rheumatoid arthriti rheumatoid arthriti ra autoimmun diseas character joint destruct synov pannus format gut microbiota dysbiosi may exert direct pathogen effect gut homeostasi may trigger host innat immun system activ gut joint axi exacerb ra howev although import gut microbiota develop progress ra wide recogn mechan regul interact gut microbiota host immun system remain incomplet defin review discuss role gut microbiota deriv biolog mediat short chain fatti acid bile acid tryptophan metabolit maintain intestin barrier integr immun balanc bone destruct ra patient bridg gut joint axi
|
D000069196;D001172
|
T047;T007;T001
|
36,275,746
|
interplay airway epithelium tissu macrophag sar cov infect first line antivir immun respons lung secur innat immun sever cell type take part process airway macrophag am among relev one am phagocyt infect cell activ immun respons antigen present cytokin releas howev precis role macrophag cours sar cov infect still larg unknown studi aim evalu role am sar cov infect use co cultur fulli differenti primari human airway epithelium hae human monocyt deriv macrophag hmdms result confirm abort sar cov infect hmdms inabl transfer virus epitheli cell howev demonstr strike delay viral replic hae hmdms ad apic epitheli infect ad inocul basolater side cultur moreov sar cov inhibit hmdms seem driven cell cell contact cytokin product togeth result show first time recruit macrophag may play import role sar cov infect limit virus replic spread
|
D000086382
|
T047;T067
|
36,275,745
|
immunogen protect efficaci recombin pastureland multocida lipoprotein vacj plpe outer membran protein h p multocida duck duck cholera duck hemorrhag septicemia high contagi diseas caus pasteurella multocida one major bacteri diseas current affect duck industri type predomin pathogen serotyp studi gene encod lipoprotein vacj plpe outer membran protein omph p multocida strain pmwsg clone express protein e coli recombin vacj kda plpe kda omph kda protein purifi subunit vaccin formul singl water oil adjuv kill vaccin prepar use singl oil coat adjuv antibodi respons duck vaccin recombin vacj plpe omph protein formul adjuv signific antigen p protect vaccin evalu via intraperiton challeng duck ld dose p multocida vaccin formul consist rvacj rplpe romph adjuv provid protect respect vaccin formul consist three recombin protein rvacj rplpe romph adjuv protect kill vaccin protect addit shown histopatholog examin tissu bacteri load detect vaccin could reduc tissu damag bacteri colon vari p find indic recombin plpe omph fusion protein formul oil adjuv potenti use vaccin candid duck cholera subunit
|
D002771;D010326;D016979
|
T047;T007
|
36,275,744
|
deciph imprint impair memori b cell matur germin center three patient common variabl immunodefici common variabl immunodefici cvid character recurr infect low serum class switch immunoglobulin isotyp poor antigen specif antibodi respons compris heterogen patient popul term clinic present under etiolog diagnosi regular associ sever decreas germin center gc deriv b cell popul peripher blood howev data b cell differenti within gc limit present multiplex approach combin histolog flow cytometri b cell receptor repertoir analysi sort gc b cell popul allow model distinct disturb gcs three cvid patient result reflect pathophysiolog heterogen under reduc circul pool post gc memori b cell plasmablast three patient patient quantit qualit b cell develop gcs relat normal patient irregular shape gcs associ reduc somat hypermut shm antigen select class switch patient high shm impair antigen select class switch larg singl clone impli increas cycl cell within irregular shape gcs lymph node patient limit number memori b cell plasma cell form reduc number circul post gc b cell general phenomenon cvid integr approach exemplifi distinct defect gc matur rang near normal morpholog function sever disturb differ facet impair matur memori b cell andor plasma cell integr dissect disturb gc b cell matur histolog flow cytometri bcr repertoir analysi contribut unravel defect essenti step memori format
|
D017074
|
T047
|
36,275,743
|
identif copper metabol cuproptosi relat subtyp predict prognosi tumor microenviron drug candid hepatocellular carcinoma copper cu essenti element organ affect surviv cell howev role copper metabol cuproptosi hepat carcinoma still unclear studi tcga databas use test set icgc databas self built databas use valid set screen class copper metabol cuproptosi relat gene cmcrgs could influenc hepat carcinoma prognosi surviv analysi differenti comparison base cmcrgs patient divid two subtyp cluster analysi c subtyp defin high copper relat subtyp c subtyp defi low copper relat subtyp clinic level compar c subtyp c subtyp higher grade patholog featur risk score wors surviv addit immun respons metabol status also differ c c specif c subtyp higher proport immun cell composit high express immun checkpoint gene c subtyp higher tide score higher proport tumor immun dysfunct exclus molecular level c subtyp higher frequenc driver gene mutat tp obscn mechanist singl nucleotid polymorph c subtyp strong transcript strand bias c mutat copi number variat c subtyp character loxl cnv gain also show high associ pdcdctla final drug sensit respons assess subtyp c subtyp lower ic valu target chemotherapeut agent sorafenib imatinib methotrex etc thus cmcrgs relat subtyp show poor respons immunotherapi better respons target agent result might provid refer precis treatment hepat carcinoma
|
D006528;D008113
|
T191
|
36,275,742
|
case report rheumatoid mening posit nmdar antibodi case treat intraven immunoglobulin rare complic rheumatoid arthriti ra central nervous system cns rheumatoid mening rm main affect mening various clinic symptom diagnost treatment approach current use practic rm case posit nmdar antibodi ab never report present studi year old man year histori ra present recurr left lower limb weak activ month result show rheumatoid factor rf anti cyclic citrullin peptid antibodi acpa posit serum nmdar ab present cerebrospin fluid csf hyperintens observ leptomening right frontal pariet lobe subtl hyperintens observ left frontal pariet lobe indic brain mri mening biopsi reveal non specif inflamm absenc rheumatoid nodul patient given ivig day admiss clinic symptom reliev lesion allevi abnorm biochem indic gradual recov week initi treatment nmdar ab present csf even treatment month follow patient serum csf acpa il level still high find show brain mri adequ diagnosi rm acpa il might specif biomark diseas activ rm ivig effect induct therapi rm studi explor whether presenc nmdar ab associ rm
|
D008581;D001172
|
T047
|
36,275,741
|
systemat review research progress non code rna neuroinflamm immun regul cerebr infarctionischemia reperfus injuri cerebr infarctionischemia reperfus injuri current diseas highest mortal disabl rate cardiovascular diseas current studi shown nerv cell die ischemia sever hour ischem stroke activ innat immun respons brain promot product neurotox substanc inflammatori cytokin chemokin reactiv oxygen speci nitrogen oxid mediat destruct blood brain barrier occurr seri inflammatori cascad reaction meanwhil express adhes molecul cerebr vascular endotheli cell increas immun inflammatori cell polymorphonuclear neutrophil lymphocyt mononuclear macrophag pass vascular endotheli cell enter brain tissu cell recogn antigen expos central nervous system brain activ adapt immun respons mediat secondari neuron damag aggrav neurolog deficit order reduc mention damag bodi induc peripher immunosuppress respons negat feedback increas incid post stroke infect process accompani chang immun status ischem brain tissu local system system grow number studi implic noncod rnas ncrnas novel epigenet regulatori element dysfunct various cell subset neurovascular unit cerebr infarctionischemia reperfus injuri particular recent studi reveal advanc ncrna biolog great expand understand epigenet regul immun respons inflamm cerebr infarctionischemia reperfus injuri identif aberr express pattern associ biolog effect ncrnas patient reveal potenti novel biomark therapeut target cerebr infarctionischemia reperfus injuri therefor review systemat present recent studi involv ncrnas cerebr infarctionischemia reperfus injuri neuroimmun inflammatori cascad elucid function mechan cerebr infarctionischemia reperfus relat ncrnas provid new opportun discoveri diseas biomark target therapi furthermor review introduc cluster regular interspac short palindrom repeat crispr display possibl transform tool studi lncrnas futur ncrna expect use target diagnos cerebr infarctionischemia reperfus injuri judg prognosi treatment therebi signific improv prognosi patient
|
D062085;D015427;D002545
|
T123;T037;T114;T047;T046
|
36,275,740
|
pulmonari hypertens link inflamm pulmonari arteri stiffen pulmonari hypertens ph progress diseas aris multipl etiolog ultim lead right heart failur predomin caus morbid mortal patient distinct inflammatori respons promin featur differ type ph various immunomodulatori intervent shown modul diseas develop progress anim model specif ph associ inflamm compris infiltr innat adapt immun cell vascular wall pulmonari vasculatur specif pulmonari vascular lesion well increas level cytokin chemokin circul blood perivascular tissu pulmonari arteri pas previous studi suggest alter hemodynam forc caus lung endotheli dysfunct turn adher immun cell releas inflammatori mediat result perivascular inflamm turn promot vascular remodel progress ph vicious cycl endotheli activ inflamm vascular remodel may develop drive diseas process pa stiffen constitut emerg research area ph relev ph diagnost prognost therapeut target respect prognost valu pa stiff rival well establish measur pulmonari vascular resist predictor diseas outcom vascular remodel arteri extracellular matrix ecm well vascular calcif smooth muscl cell stiffen vascular wall thicken tissu fibrosi contribut pa stiffen associ inflamm vascular stiffen well establish system vascular diseas atherosclerosi vascular manifest system sclerosi similar connect inflammatori process pa stiffen far address context ph review discuss potenti link inflamm pa stiffen specif focus vascular calcif ecm remodel ph
|
D006976;D014652;D061205
|
T047;T046
|
36,275,739
|
select serotonin reuptak inhibitor inflammatori bowel diseas benefici malpractic ibd chronic inflammatori diseas manifest grow health problem crohn coliti council offici ratifi anti depress routin regimen ibd patient howev physician empir prescrib rectifi function bowel consequ pain allevi psychiatr comorbid side ssris prescript accompani advers effect sleep disturb prolong intermitt hypoxia throughout sleep disturb sleep apnea provok period reduct partial oxygen pressur gradient gut lumen promot gut microbiota dysbiosi induc intestin inflamm phenomenon evid repres higher amount serotonin associ crohn diseas challeng previous knowledg ssris worsen ibd cours evid answer question claim anti inflammatori properti central peripher ssris illumin substanti element compar serotonin elev respons ibd pathogenesi howev later clinic evid favor benefit ssris henc review molecular mechan clinic evid scrutin integr clarifi interf molecular mechan justifi support disprov clinic evid biphas dose depend serotonin behavior accompani ssri shift function use long term assum paramet lead ibd patient advers outcom despit research need elucid effect ssri consumpt ibd patient period prescript ssris month interv recommend
|
D015212;D003424;D008318
|
T047;T080
|
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