PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,255,137 | recent advanc understand self assembl macroion solut via molecular model macroion solut behav quit differ small ion solut colloid suspens repres previous miss import transit stage connect solut polyelectrolyt includ protein dna eg similar blackberri format virus capsid format synthesi character produc immens databas regard self assembl behavior macroion solut result mani empir rule guidelin theori simul sore need connect dispar thread cohes coher narrat macroion solut theori provid guidanc futur work recent develop versatil coars grain model specif design model self assembl macroion solut answer outstand question solut behavior macroion includ sourc attract forc like charg macroion self assembl monolay structur | D003102;D011506 | T123;T122;T116 |
36,255,126 | spatial reprogram receptor organ switch cell behavior use dna origami templat aptam nanoarray receptor oligomer high complex molecular process modul diverg cell signal howev lack molecular tool systemat interrog receptor oligomer govern signal respons develop dna origami templat aptam nanoarray dota enabl precis program oligomer receptor tyrosin kinas rtk defin valenc distribut stoichiometri ligand receptor interfac dota allow advanc receptor manipul array either monomer aptam ligand mal oligamer receptor monom elicit artifici signal dimer aptam ligand dal preorgan receptor dimer recapitul natur activ demonstr multival nanoscal space receptor oligomer coordin influenc activ level receptor tyrosin kinas signal furthermor illustr dota modul receptor oligomer could function signal switch promot transit epithelia mesenchym like cell demonstr robust control cellular behavior togeth present versatil one dna nanoplatform systemat investig regul receptor mediat cellular respons | D020794;D004247 | T123;T116;T192;T126;T114 |
36,255,103 | spin coat base facil annular photodynam intraocular len fabric effici safer posterior capsular opacif prevent posterior capsular opacif pco common complic cataract surgeri primarili caus prolifer residu len epitheli cell lec len capsul previous studi demonstr drug elut intraocular len iol aim situ elimin lec effect promis way prevent pco howev potenti toxic antiprolif drug adjac tissu safeti drug elut iol still high import issu solv investig facil photodynam coat modifi iol develop effect safer pco prevent annular poli lactid co glycol acid plga coat load photosensit chlorin e ce prepar spin coat techniqu optic properti investig show ce plga coat particular suitabl iol surfac modif vitro cell cultur investig show ce plga coat modifi iol effect elimin lec treat light illumin wherea appear good cytocompat without irradi investig cell elimin mechan show apoptosi hlec may associ cytomembran disrupt induc ros generat photodynam coat light illumin vivo implant experi confirm desir pco prevent effect well safeti biocompat surround tissu thus facil ce plga coat provid effect yet safe altern iol surfac modif pco prevent | D007910;D058442;D007903;D007908 | T047;T074;T023 |
36,255,101 | decod fine flavor properti dark chocol fine flavor properti chocol fruiti floral cocoa like decod molecular level first time molecular composit six chocol made liquor referenc specif sensori attribut analyz screen odor activ molecul aroma extract dilut analysi select compound quantit overal aim decod distinct fine flavor attribut molecular level acid fruiti flavor note associ high dose threshold factor dot factor acet acid fruiti smell ester ethyl methylbutanaot ethyl methylbutano methylbutyl acet respect cocoa like roasti flavor note associ high dot factor methylbutan methylbutan hydroxi dimethylfuran h one dimethyltrisulfan floral astring flavor link high dot factor epicatechin procyanidin b procyanidin c phenylethan ol | D000069956;D002392;D002099;D055549 | T168;T121;T002;T109 |
36,255,100 | synthesi nucleosid nucleotid analogu cyclize guanin base tetramethoxypropan deoxi erythropentofuranosyl pyrimido purin h one mdg endogen dna adduct bacteri mammalian cell could explor biomark oxid stress nonetheless lack effici methodolog prepar mdg hamper deep investig biosynthesi biorelev process project aim address issu develop high effici method synthes mdg analogu method wide function group toler various guanin base nucleosid nucleotid suitabl reaction furthermor larg scale derivat reaction carri showcas possibl biochemist studi dna damag repair process futur | D009705;D009711 | T121;T114 |
36,255,071 | role deltanotch like epiderm growth factor relat receptor gastric cancer patient cell clinic signific gastric cancer gc common digest system malign aim studi explor role deltanotch like epiderm growth factor relat receptor dner gc patient cell gene express omnibus data base public databas use analyz dner express gc patient total case gc adjac tissu sampl retrospect obtain analyz dner express mtt assay conduct measur cell viabil apoptosi rate gc cell determin flow cytometri migrat invas detect transwel assay real time polymeras chain reaction western blot perform measur dner express bioinformat tool exhibit dner express signific upregul gc also found gc tissu cell high level dner close relat tumor size sex lymph node metastasi addit surviv rate patient high dner express decreas furthermor knockdown dner inhibit prolifer migrat invas induc apoptosi rate gc cell dner upregul gc knockdown dner inhibit growth metastasi dner dner may potenti prognost biomark therapeut target gc patient | D013274 | T191 |
36,255,070 | venetoclax induc vitiligo patient chronic lymphocyt leukemia venetoclax high select bcl inhibitor oral bioavail drug approv first line therapi chronic lymphocyt leukemia cll combin obinutuzumab well monotherapi set relaps cll although life threaten side effect well known includ tumor lysi syndrom cytopenia other less known side effect includ skin reaction skin rash common report literatur often mild life threaten case report author describ potenti second case venetoclax induc vitiligo report literatur year old man cll rai stage ii cytogenet show q delet cell q partial delet cell develop vitiligo extrem year treatment decis made continu venetoclax close monitor side effect mild debilit patient continu well although vitiligo associ increas mortal risk develop associ increas psycholog stress mechan vitiligo develop remain unclear may associ drug induc vitiligo improv cancer prognosi howev larger studi need carri prove hypothesi | D000970;D064420;D015451;D014820 | T121;T109;T191;T037;T047;T046 |
36,255,069 | circ upregul ark express elev fluorouracil resist hepatocellular carcinoma bind mir p chemoresist limit clinic treatment cancer patient studi aim research regulatori function circ fluorouracil fu resist circ microrna p mir p ampk relat protein kinas ark level assay via quantit revers transcript pcr coloni format abil assess coloni format assay flow cytometri perform cell cycl cell apoptosi analysi caspas activ detect use caspas activ assay target analysi conduct via rna pull assay dual luciferas report assay rna immunoprecipit assay vivo assay perform establish xenograft model mice circ upregul fu resist hepatocellular carcinoma hcc tissu cell circ downregul repress fu resist cancer progress fu resist hcc cell circ interact mir p inhibit mir p revers regul sh circ fu resist ark target mir p ark regul circ via target mir p circ regul fu resist part upregul ark express fu sensit enhanc circ level reduct vivo find unravel circ elev fu resist hcc spong mir p upregul level ark indic circ might use target improv fu therapi hcc | D006528;D008113;D035683;D011494;D012097 | T123;T116;T191;T126;T114 |
36,255,068 | circ promot cisplatin resist progress ovarian cancer upregul raba sequest mir circular rnas act critic regul tumorigenesi chemoresist ovarian cancer oc herein work aim probe function mechan circ cisplatin ddp resist progress oc potenti valu clinic | D035683;D010051;D020761 | T123;T116;T191;T126;T114 |
36,255,067 | g protein subunit gamma promot prolifer metastasi glycolysi breast cancer cell wnt catenin pathway gng suggest exert critic effect tumor develop human be howev function relat mechan within breast cancer bc still unclear regard present work focus identifi evalu gng function reveal possibl molecular mechan subcutan tumorigenesi model nude mice vitro cell model establish relationship gng express bc studi knockdown overexpress experi prolifer migrat invas epitheli mesenchym transit emt liver cancer cell line overexpress silenc gng detect furthermor pathway mechan gng evalu molecular level perform verifi possibl target mechan action comparison normal tissu gng level within bc tissu higher addit gng overexpress stimul bc cell prolifer invas migrat emt bc cell reduc gng express exhibit signific decreas glucos uptak lactat level atp concentr addit gng knockdown inhibit wnt catenin signal studi indic gng may generat vital function bc result current work demonstr gng effect bc patholog process also provid refer develop new target therapi bc | D001943;D060449;D044388 | T123;T191;T116;T044 |
36,255,065 | loud auditori distractor difficult ignor work memori perform mark disrupt task irrelev sound play item present retent preregist replic studi systemat examin role intens two type auditori distract first type distract chang state effect ie increas disrupt chang state relat steadi state sequenc second type auditori deviant effect ie increas disrupt auditori deviant relat steadi state sequenc previous experi chang state effect independ intens whether deviat intens lead increas disrupt yet examin replic classic find increas disrupt chang state relat steadi state sequenc independ intens contrari previous studi found unexpect main effect intens steadi state chang state sequenc present db disrupt present db suggest intens play import role previous assum disrupt work memori perform furthermor test predict violat expect account accord deviant distractor lower higher intens rest sequenc equal disrupt result consist predict | D001288;D001307 | T041 |
36,255,064 | action alway speak louder word financi dis incent eg bonus tax social incent eg public prais typic propos method encourag greater cooper benefit howev cooper requir exert effort intervent might alway effect incent tend high motiv choos exert effort evid suggest less effect behavior effort execut aim exploratori studi incorpor insight empir investig effect social incent cooper effort end modifi public good game task requir effort contribut common good crucial manipul involv incorpor social incent task link choic peopl made b effort action exert find suggest line recent effort base decis make model social incent stronger effect cooper effort link choic peopl make rather actual effort exert studi demonstr potenti benefit elicit priori declar cooper effort tie social incent encourag greater effort benefit | D003299;D009042 | T078;T041;T054;T080 |
36,255,063 | anchor sleep inertia mani occup set requir individu make import decis immedi awaken although plethora psycholog research separ examin sleep anchor effect decis make littl known interact present studi seek shed light link sleep inertia perform impair immedi awaken individu suscept anchor bias propos sleep inertia would moder particip adjust anchor sleep inertia lead less cognit effort invest result stronger anchor effect one hundr four subject random assign experiment group answer anchor task immedi awaken nighttim control group answer anchor task daytim find replic well establish anchor effect higher anchor led particip higher estim lower anchor find signific effect sleep inertia sleep inertia group report greater sleepi invest less cognit effort compar control group systemat anchor differ emerg cognit effort qualifi mediat anchor effect bayesian analys provid empir evid null find implic anchor literatur futur research discuss | D012890;D014851 | T033;T040;T041 |
36,255,062 | effect semant transpar flanker task studi tri replic extend semant transpar morpholog effect use flanker lexic decis paradigm grainger et al first experi stem use flanker target word could truli morpholog hunt hunter hunt pseudomorpholog corn corner corn form relat flanker broth brothel broth half trial relat flanker employ half unrel word present flanker eg tabl player tabl result show facilit effect relat condit main effect differ experiment condit result interpret term orthograph facilit take place whole stem present flanker second experi short deriv suffix use flanker target employ first experi result show inhibitori effect magnitud transpar pseudomorpholog condit effect form condit find suggest inhibitori effect morphem activ sever lexic candid compet recognit overal result interpret term cognit requir experiment task item select current model morpholog process | D021641;D012660 | T078;T041 |
36,255,060 | impact gallic acid tumor suppress modul redox homeostasi purinerg respons vitro preclin glioblastoma model glioblastoma gbm deadliest primari brain tumor adult due high rate relaps current treatment therefor search therapeut altern urgent gallic acid ga potent natur antioxid antitumor modulatori action purinerg signal studi investig cytotox effect ga rat gbm c cell line astrocyt cultur analyz role regul oxid stress purinerg enzym involv gbm prolifer cell expos ga andor h next effect ga evalu preclin model gbm wistar rat treat mgkg ga day cerebr system redox status degrad adenin nucleotid nucleosid circul platelet lymphocyt serum evalu result demonstr ga select anti glioma activ vitro without induc cytotox astrocyt furthermor ga prevent oxid stress chang hydrolysi nucleotid gbm cell anti glioma effect also observ vivo ga reduc tumor volum interest ga decreas oxid damag induc tumor brain serum platelet also prevent chang degrad nucleotid nucleosid lymphocyt platelet serum result indic first time therapeut potenti ga preclin model gbm whose effect may relat role redox purinerg modul | D005909;D005910;D001932 | T191 |
36,255,055 | lack ownership mobil phone could hinder rollout mhealth intervent africa mobil health mhealth intervent requir ownership mobil phone investig throughout africa estim percentag individu mobil phone african countri identifi relationship ownership proxim health clinic hc quantifi inequ ownership investig basic mobil phone bps smartphon sps sps connect internet bps use nation repres data collect individu round afrobaromet survey use bayesian multilevel logist regress model analys find individu countri mobil phone bps sps individu live close hc higher odd ownership aor bayesian highest posterior densiti hpd region men compar women twice odd ownership aor hpd region urban resid compar rural resid almost three time odd aor hpd region amongst mobil phone owner near three time odd own sp aor hpd region ownership increas age peak year old decreas individu like sp bp older individu like bp sp probabl ownership decreas live poverti index howev poorest individu sps digit devic need mhealth intervent equal avail within popul found current situat roll mhealth intervent africa like propag alreadi exist inequ access healthcar | D040421;D017216 | T058;T073 |
36,255,054 | tissu specif mitochondri higdc promot oxygen sensit carotid bodi chemoreceptor mammalian carotid bodi arteri chemoreceptor function earli warn system hypoxia trigger acut life save arous cardiorespiratori reflex serv role carotid bodi glomus cell high sensit decreas oxygen avail mitochondria plasma membran signal protein implic oxygen sens glomus cell mechan under mitochondri sensit hypoxia compar cell unknown identifi higdc novel hypoxia induc gene domain factor isoform electron transport chain complex iv interact protein almost exclus express carotid bodi therefor general necessari mitochondri function import higdc requir carotid bodi oxygen sens enhanc complex iv sensit hypoxia thus propos higdc promot exquisit oxygen sens carotid bodi illustr special mitochondria use sentinel metabol stress elicit essenti adapt behavior | D002344 | T023 |
36,255,053 | phenotyp base forward genet screen identifi dnajb sick sinus syndrom gene previous show generat protein trap librari made gene break transposon gbt zebrafish danio rerio could use facilit novel function genom annot toward understand molecular underpin human diseas ichino et al report signific applic librari discov essenti gene heart rhythm disord sick sinus syndrom sss sss group heart rhythm disord caus malfunct sinus node heart primari pacemak partial owe age associ phenotyp manifest low express molecular mechan sss remain difficult deciph gbt line screen generat collect zebrafish insert cardiac zic mutant mutant trap gene cardiac express employ electrocardiograph measur screen zic line identifi three gbt mutant sss like phenotyp detail function studi one arrhythmogen mutant gbt zebrafish mous model unveil dnajb novel sss causat gene uniqu express pattern within subpopul sinus node pacemak cell partial overlap express hyperpolar activ cyclic nucleotid gate channel hcn support heterogen cardiac pacemak cell | D012804;D015027 | T047;T013 |
36,255,051 | delin transcript landscap clonal divers virus specif cd cell chronic viral infect although recent evid indic cd cell respond chronic viral infect function heterogen understand development relationship subset determin transcript landscap compar acut infect counterpart remain unclear addit whether cell intrins factor tcr usag influenc cd cell fate commit persist infect previous studi herein perform singl cell rna sequenc scrna seq combin singl cell cell receptor sequenc sctcr seq virus specif cd cell isol mice infect chronic lymphocyt choriomening virus lcmv infect identifi sever transcript distinct state among th tfh memori like cell subset form peak infect includ presenc previous unrecogn slamf subset cytolyt featur show relat distribut popul differ substanti acut persist lcmv infect moreov progeni cell clone display membership within transcript uniqu popul overal support one cell multipl fate model small fraction clone display bias cell fate decis suggest tcr usag may impact cd cell develop chronic infect import compar analys reveal subset specif core gene express program differenti regul cd cell respond acut chronic lcmv infect togeth data may serv use framework allow detail interrog clonal distribut transcript circuit under cd cell differenti chronic viral infect | D008216;D006086 | T047 |
36,255,049 | risk factor outcom concurr sequenti multivir cytomegalovirus epstein barr virus bk virus adenovirus viral reactiv transplant reactiv viral infect occur frequent immunosuppress popul particular solid organ sot allogen haematopoiet cell hct transplant patient concurr sequenti multivirus infect common yet risk factor outcom remain unclear review aim identifi patient vulner multivirus infect character impact increas viral burden formul prevent treatment strategi | D001739;D020031;D000257;D006086;D018380 | T061;T005;T047 |
36,255,040 | follicular lymphoma updat diagnosi manag follicular lymphoma fl general indol b cell lymphoprolif disord transform follicular center b cell fl character diffus lymphadenopathi bone marrow involv splenomegali extranod involv less common cytopenia relat common constitut symptom fever night sweat weight loss uncommon absenc transform diffus larg b cell lymphoma | D008224 | T191 |
36,255,039 | associ probiot treatment antibiot male accessori gland infect male accessori gland infect magi repres frequent diseas common treat antibiot alon howev approxim patient persist infect detect intestin dysbiosi involv pathogenesi prostat aim evalu efficaci antibiot treatment associ specif probiot supplement total infertil patient microbiolog analysi semen andor prostat secret posit gram negat bacteria enrol patient receiv antibiot treatment fluoroquinolon total patient receiv commerci associ enterococcus faecium saccharomyc boulardii antibiot treatment follow treatment lactobacilli treatment complet microbiolog analysi repeat polymicrobi infect observ patient infect due singl germ report patient treatment perform complet erad negat semen cultur microbiolog analysi prostat secret observ patient patient receiv antibiot alon p report negat microbiolog analysi persist infect observ patient infect due enterococcus faecali escherichia coli studi repres first approach demonstr efficaci specif probiot treatment reduc rate persist infect patient magi | D005832;D019936;D011472 | T047;T007 |
36,255,029 | state art self luminesc win win situat self luminesc elimin real time extern optic excit effect avoid background autofluoresc photoluminesc endow ultrahigh signal nois ratio sensit bioassay furthermor situ generat emit photon appli develop excit free diagnost therapeut agent deepli seat diseas enhanc self luminesc refer aggreg induc emiss aie integr self luminesc system endow merit also superior includ stronger lumin bright longer half life compar tradit self luminesc platform emerg boom hotspot enhanc self luminesc facilit win win cooper aggreg induc emiss self luminesc techniqu becom power tool interdisciplinari research tutori review summar advanc aie assist self luminesc includ chemiluminesc afterglow imag start discuss design work principl luminesc mechan self luminesc fuel versatil integr approach advantag broad rang repres exampl biosensor oncotherapi final current challeng perspect discuss actuat develop enhanc self luminesc agent biomed diagnosi treatment | D015374;D049408 | T130;T059;T075 |
36,255,012 | perform prognost score predict day postop mortal covid patient emerg surgeri retrospect cohort studi risk assess prognost score though import scarc studi emerg surgic patient covid infect | D000086382 | T047;T067 |
36,254,967 | curcumin base ionic pt ii complex antioxid antimicrobi activ seri novel cation curcumin base pt ii complex neutral nn ligand triflat anion counterion nn pt curc cf synthesis fulli characteris antioxid radic scaveng activ complex measur spectrophotometr use dpph intern probe comput strategi exploit ascertain mechan antioxid action curcumin h curc pt ii complex final compound test vitro growth inhibitori activ two bacteria staphylococcus aureus escherichia coli disk diffus techniqu differ pt ii complex solut concentr effect complex h curc investig | D003474;D056831;D000890 | T121;T104;T130;T109 |
36,254,939 | econom impact rural healthcar rural economi rapid review one critic compon rural communiti healthcar system rural healthcar system essenti rural communiti wors health outcom compar urban area rural healthcar system might also posit impact rural economi rural area health servic threaten reduct closur rapid review carri examin impact rural healthcar system declin rural economi | D004501;D019035;D017216 | T065;T058;T073;T093 |
36,254,938 | preval obes elev bodi mass index along progress rural cross section studi canadian longitudin studi age obes import public health concern larg studi rural urban differ preval obes lack purpos compar bodi mass index bmi obes canada use expand definit rural | D009765;D012424 | T047;T098;T102 |
36,254,937 | orthopaed outreach innov programm orthopaed patient remot area newfoundland labrador wait time see orthopaed consult lengthi remot communiti labrador citi goos bay locat labrador provinc newfoundland labrador often orthopaed specialist local patient requir travel great distanc attend clinic appoint object report describ orthopaed outreach programm patient receiv fractur assess care musculoskelet concern two local clinic visit orthopaed surgeon also describ justif orthopaed outreach programm list benefit financi otherwis | D009985 | T091 |
36,254,936 | northern ontario rural physician team long studi examin state rural northern physician group agreement rnpga physician team rural northern ontario term demograph intent stay length stay number physician relat rnpga design complement percept various workplac communiti factor | D010820;D019035 | T093;T058;T073;T097 |
36,254,926 | microcrystallin tyrosin adsorb immunotherapi purpos articl provid overview literatur pertain use microcrystallin tyrosin mct immunotherapi emphasi recent develop | D014443;D001249 | T123;T047;T121;T116 |
36,254,925 | strengthen case intralymphat immunotherapi intralymphat immunotherapi ilit promis novel method immunotherapi short conveni may effect result vari effort unravel real valu treatment ongo method use assess effect clinic trial vari difficult compar studi | D003888;D006967 | T061;T046 |
36,254,924 | manag bronchomalacia infant post cardiac surgeri use synchron nasal duopap novel technolog tracheo bronchomalacia tbm weak structur integr cartilagin ring arch may occur isol prematur secondarili associ various congenit anomali bronchomalacia common associ congenit heart diseas convent treatment option includ posit pressur ventil without tracheostomi surgic correct extern compress airway stent | D055091;D006348;D055090 | T061;T047 |
36,254,923 | use ketamin induct agent anesthesia pulmonari thromboendarterectomi surgeri case seri pulmonari thromboendarterectomi pte surgeri treatment choic patient chronic thromboembol pulmonari hypertens cteph induct anesthesia patient sever pulmonari hypertens pht challeng risk cardiovascular collaps administr ketamin patient pht controversi recommend contraind use howev ketamin use safe children sever pht present retrospect case seri adult patient sever pht present pte surgeri use intraven ketamin co induct anesthet agent | D000758;D006976;D007649;D011655 | T061;T121;T109;T047;T046 |
36,254,922 | use intraop coronari angiographi guid surgic intervent coronari arteri bypass graft surgeri follow coronari arteri bypass graft surgeri graft patenc major factor contribut patient morbid mortal sever modal avail assess graft patenc intra op use anesthesiologist surgeon howev modal advantag disadvantag summar case report illustr case angiographi continu gold standard coronari anatomi assess perform easili use portabl digit fluoroscop system | D001026 | T061 |
36,254,921 | patent vertic vein devic closur peri procedur anesthet manag present peri procedur anesthet manag case transcathet closur unlig patent vertic vein vv year old male child oper case obstruct supra cardiac total anomal pulmonari venous connect tapvc present signific left right shunt caus symptom right heart failur procedur carri success deep sedat monitor anesthesia care mac specif clinic implic anesthet manag perspect highlight discuss report | D000777;D011667;D012587 | T121;T019;T023;T039;T047 |
36,254,920 | combin low dose spinal anesthesia epidur anesthesia anesthet manag patient uncorrect doubl outlet right ventricl dorv underw cesarean section pregnant patient uncorrect doubl outlet right ventricl dorv undergo cesarean section challeng anesthesiologist present case year old woman gestat age week dorv ventricular septal defect pulmonari hypertens stage c function class iii heart failur success manag use combin low dose spinal anesthesia bupivacain mg adjuv fentanyl mcg epidur ropivacain fentanyl mcg tv cc given minut birth babi hemodynam stabl low dose spinal anesthesia end oper | D000767;D000773;D000775;D004310 | T061;T019;T047 |
36,254,919 | activ paradox pulmonari emboli first trimest pregnanc captur paradox embol real time challeng recent literatur present uniqu case year old gp femal week gestat present dyspnea activ thrombus undiagnos patent foramen oval found requir emerg surgic intervent posit outcom presenc deep vein thrombosi inferior vena caval thrombus patent foramen oval pulmonari arteri thrombi contemporarili document knowledg minim literatur present | D019320;D054092;D011655;D013927 | T019;T047;T046 |
36,254,918 | post cardiopulmonari bypass longitudin strain provid higher prognost abil baselin strain chang strain global longitudin strain gls measur speckl track echocardiographi demonstr excel prognost abil predict major advers cardiac event cardiac surgeri howev optim time intraop gls measur provid best prognost valu unclear | D000777;D002315 | T061;T121;T039 |
36,254,917 | c reactiv protein kinet cardiac surgeri retrospect multicent studi recognit postop infect cardiac surgeri challeng biomark may use recogn infect earli stage literatur controversi | D002097;D047549 | T061;T129;T116 |
36,254,916 | periop dexmedetomidin reduc delirium coronari arteri bypass graft surgeri prospect singl blind observ studi delirium common seen complic cardiac surgeri dexmedetomidin anti inflammatori properti effect attenu postop delirium | D003693;D020927;D015742 | T121;T109;T048 |
36,254,915 | preoper fibrinogen level postcardiac surgeri morbid mortal rate high preoper fibrinogen level associ reduc bleed rate cardiac surgeri fibrinogen direct involv inflammatori process cardiovascular risk factor whether high fibrinogen level cardiac surgeri risk factor mortal morbid remain unclear | D005340;D019106;D006348 | T061;T123;T121;T116;T046 |
36,254,914 | impact one day three dimension transesophag echocardiographi workshop clinic practic singl academ centr transesophag echocardiographi tee power diagnost tool becom integr part manag cardiac surgeri patient develop one day tee workshop specif design meet need periop cardiac anaesthesiologist hypothes particip workshop would increas uptak tee routin periop practic | D006348;D019560 | T061;T060 |
36,254,913 | measur improv hospit outcom patient undergo surgic repair anomal origin left coronari arteri pulmonari arteri anomal origin left coronari arteri pulmonari arteri alcapa rare congenit anomali lead progress left ventricular dysfunct mitral regurgit conduct studi investig various measur optim outcom surgic correct alcapa | D063748;D003330;D018487 | T019;T047;T046 |
36,254,912 | effect recombin erythropoietin hemoglobin level blood transfus need patient preoper anemia undergo cardiac surgeri preoper anemia import relat common problem patient undergo cardiac surgeri treatment crucial improv postop outcom use recombin erythropoietin one suggest method field therefor present studi sought evalu effect recombin erythropoietin hemoglobin hb level blood transfus need cardiac surgeri patient preoper anemia | D000740;D006348;D004921 | T061;T121;T116;T125;T047 |
36,254,911 | retrospect analysi incid outcom factor associ occurr euglycem ketoacidosi diabet patient sodium glucos co transport inhibitor undergo cardiac surgeri sglti new class drug use type diabet sglti known caus euka periop period euglycem ketoacidosi euka caus life threaten metabol acidosi periop set though event rate sglti associ diabet ketoacidosi nonop set low incid among peri oper patient high remain unknown | D006348;D003924;D016883;D000077203 | T061;T121;T047;T109 |
36,254,910 | citrat chang viscoelast haemostat assay cardiopulmonari bypass viscoelast hemostat assay vha common use identifi specif cellular humor caus bleed cardiac surgeri patient cardiopulmonari bypass cpb alter coagul observ vha citrat vha approxim fresh whole blood vha kaolin use activ healthi volunt suggest noncitr blood optim citrat blood point care analysi popul | D002315;D006490 | T061;T121 |
36,254,909 | comparison success rate radial arteri cannul ultrasound guid convent palpat techniqu elder patient undergo cardiothorac surgeri ultrasound guid usg radial arteri cannul standard palpat techniqu increas first attempt rate pediatr adult patient object studi evalu benefit usg versus palpat techniqu improv first attempt rate elder patient | D002406;D017534 | T061;T058;T023 |
36,254,908 | prospect studi various anesthet techniqu patient acyanot congenit heart diseas undergo devic closur transcathet devic closur congenit heart defect chd recent gain popular limit literatur exist regard ideal anesthet techniqu procedur studi periop anesthet manag effect hemodynam complic rate patient undergo devic closur | D000777;D004374;D005045;D006330;D006344;D006345;D015742 | T121;T039;T109;T019 |
36,254,907 | random control studi nebul colistin adjunct therapi ventil associ pneumonia pediatr postop cardiac surgic popul ventil associ pneumonia vap multidrug resist mdr gram negat organ common problem intens care unit icu aerosol antibiot enhanc efficaci system antibiot ad adjuv | D006348;D003091;D053717 | T061;T047;T195;T116 |
36,254,906 | ultrasound guid erector spina plane block replac thorac epidur analgesia postop analgesia pediatr patient undergo thoracotomi prospect random control trial mani analges modal investig pediatr thoracotomi studi analges efficaci unilater continu ultrasound guid erector spina plane block espb compar thorac epidur pediatr patient undergo thoracotomi | D015360;D009407;D010372 | T061;T091 |
36,254,905 | one year experi adopt tabl extub protocol follow pediatr cardiac surgeri report initi experi tabl extub follow cardiac surgeri congenit heart diseas assess efficaci safeti potenti fast track patient intens care unit icu | D006348;D006330 | T061;T019 |
36,254,904 | vasoplegia predict preoper platelet leucocyt conglomer indic cardiac surgeri vasopleg retrospect singl center studi post cardiotomi vasoplegia syndrom vs often link exagger inflammatori respons cardiopulmonari bypass cpb time prognost role platelet leucocyt indic plis leucocyt indic lis platelet lymphocyt ratio plr system immun inflamm index sii platelet neutrophillymphocyt aggreg index system inflamm aisi platelet monocyt neutrophillymphocyt neutrophil lymphocyt ratio nlr system inflamm respons index siri monocyt neutrophillymphocyt respect recent describ divers inflammatori set | D006348;D056987 | T061;T046;T037 |
36,254,903 | serum gamma glutamyltransferas ggt coronari arteri diseas explor asian indian connect need identifi novel marker cad independ tradit cv risk factor one gamma glutamyl transferas ggt marker increas oxid stress given high preval cad asian indian link ggt cad need studi | D003324;D005723 | T047;T126;T116 |
36,254,902 | intraop blood collect without fluid replac cardiac surgeri retrospect analysi transfus rate cardiac surgeri high | D058186;D006348;D013903 | T061;T047;T091;T037 |
36,254,901 | use cerebr oximetri cardiac surgeri systemat review meta analysi random control trial high preval cerebr desatur associ postop neurolog complic cardiac surgeri howev evid use cerebr oximetri correct cerebr desatur reduct postop complic remain uncertain literatur systemat review meta analysi aim examin effect cerebr oximetri incid postop cognit dysfunct cardiac surgeri databas medlin embas central search incept april random control trial compar cerebr oximetri blindedno cerebr oximetri adult patient undergo cardiac surgeri includ observ studi case seri case report exclud total trial n includ review pool data demonstr patient cerebr oximetri associ lower incid postop cognit dysfunct control group studi n odd ratio confid interv ci p certainti evid low term postop delirium ci p certainti evid low postop stroke ci p certainti evid high signific differ p report cerebr oximetri control group meta analysi use cerebr oximetri monitor cardiac surgeri demonstr lower incid postop cognit dysfunct howev find must interpret caution due low level evid high degre heterogen lack standard cognit assess cerebr desatur intervent | D006348;D003693;D000079690 | T061;T048 |
36,254,898 | bio orthogon activ tetraphenylen tetrazin aggreg induc emiss fluorogen probe tetrazin base bio orthogon activ fluorogen probe drawn great attent due excel perform bioimag howev suffer aggreg caus quench acq problem herein develop set novel tetrazin modifi tetraphenylen tpes bio orthogon activ aggreg induc emiss aie fluorogen probe fluoresc aie featur quench tetrazin mediat bond energi transfer tbet mechan activ upon convert tetrazin pyridazin via invers electron demand diel alder iedda reaction activ cycloadduct display notabl fluoresc enhanc larg stoke shift high fluoresc quantum yield evid aie activ featur manipul length posit linker enabl fine tune photophys properti probe overlong planar linker lead aie acq transform also design bi tetrazyl substitut probe exhibit higher turn ratio mono tetrazyl analog owe doubl quench function react doubl clickabl linker fluoresc macrocycl obtain restrict free rotat phenyl ring tpe use organell pretarget strategi succeed appli probe mitochondria specif bio orthogon imag live cell wash condit expect provid power tool biomed applic | D005456;D006571 | T130;T109 |
36,254,897 | chiral organ inorgan hybrid perovskit base l histidin novel chiral hybrid perovskit high demand various advanc applic spintron optoelectron photovolta etc howev scope new materi still limit herein present new hybrid perovskit base upon chiral amino acid l histidin general formula new compound denot l hish pbbr x x l l histidin x perovskit character similar structur motif consist corner share lead halid octahedra arrang one layer thin inorgan slab interleav organ layer establish l histidinium cation l histidin provid break spatial pariti perovskit result non centrosymmetr crystal structur compound show multiband absorpt nm iodid perovskit addit new compound display pronounc singl peak photoluminesc fine blue shift upon gradual substitut iodin bromin new perovskit exhibit excel thermal stabil k k bromid iodid compound respect result show abil l histidin produc novel high demand chiral hybrid perovskit | D006639;D007454 | T123;T197;T121;T116 |
36,254,877 | multifunct carbon dot photosensit nanoassembl inhibit amyloid aggreg suppress microbi infect overcom blood brain barrier amyloid aggreg microbi infect blood brain barrier bbb consid critic obstruct treatment alzheim diseas ad present exist treatment strategi rare abl overcom critic factor herein propos innov treatment strategi design multifunct nanoassembl ycds ce coassembl photosensit chlorin e yellow fluoresc carbon dot endow ycds ce function photodynam phototherm therapi pdt ptt compar report inhibitor ycds ce suppress amyloid aggreg day disaggreg aggreg reduc amyloid aggreg induc cytotox prevent microbi growth pdt ptt moreov ycds ce specif target amyloid aggreg visual label amyloid aggreg ycds ce also cross bbb upon near infrar light irradi clear amyloid deposit appp mice pdt ptt meanwhil ycds ce caus signific negat effect normal cell tissu base method ppt ptt treatment research deepli explor effect novel nanoassembl two hypothes ad open novel therapeut paradigm research amyloid relat diseas | D002735;D011166;D010778 | T061;T123;T109 |
36,254,875 | effici synthesi spiro diheterocycl via multi compon dicycl reaction facil synthet protocol prepar spiro diheterocycl easili avail aminoacetophenon isocyan benzoquinon quinon monoimin mild condit develop multi compon transform character effici construct two heterocycl one valuabl quaternari carbon one pot via situ cyclize respiroannul strategi moreov reaction show broad substrat scope generat divers five member oxaspiro | D017953 | T109 |
36,254,865 | high preval genet divers singl ancestr origin azol resist aspergillus fumigatus indoor environ walailak univers southern thailand studi explor preval genet divers popul structur azol resist aspergillus fumigatus araf walailak univers southern thailand three hundr sampl collect dwell workplac screen azol resist test drug suscept molecular detect alter cypa gene csp type perform nucleotid polymorph haplotyp divers calcul select neutral test perform total fumigatus isol identifi isol display resist medic azol preval araf fumigatus isol almost azol resist isol harbour amino acid substitut hotspot region cypa gene especi nearbi g residu report caus azol resist aris long term azol treatment moreov araf isol harbour tandem repeat promot region report caus resist aris use azol fungicid crop protect final select neutral test also suggest impact natur select dna divers therefor hypothes factor caus high preval araf area vivo ex vivo acquir resist | D001393;D005659 | T131;T109 |
36,254,863 | plantaricin revers resist ciprofloxacin multidrug resist staphylococcus aureus inhibit efflux pump overexpress staphylococcus aureus efflux pump common associ antibiot resist caus convent antibiot unsuccess combat multidrug resist bacteri infect reduc activ efflux pump urgent requir tackl problem found plantaricin plna antimicrobi peptid deriv lactobacillus plantarum synergist effect ciprofloxacin cip reduc ic cip eight time subsequ chang membran permeabl membran potenti reactiv oxygen speci ros determin chang explain synergist effect previous observ ethidium bromid intak efflux experi show plna inhibit function efflux pump bind alter structur mepa nora lmrs seri plna mutant design explor under mechan show charg foam plna predomin factor affect structur nora skin wound infect model plna signific reduc dose cip reliev inflamm promot wound heal indic plna cip synergi persist vivo overal plna reduc use cip combin therapi allow continu use cip kill mdr aureus multidrug resist staphylococcus aureus threaten life tenaci pathogen caus infect hospit communiti anim husbandri various studi show efflux pump inhibitor epi consid potenti therapeut agent rejuven activ antibiot unfortun small molecul epi exhibit sever side effect limit use clinic applic present studi show new epi plantaricin produc lactobacillus plantarum low cytotox haemolysi power inhibitori activ efflux pump therefor help design new epi control infect mdr aureus | D002939;D055624 | T121;T007;T195;T109 |
36,254,861 | mir p promot ferroptosi induc cardiomyocyt death respond oxygen glucos deprivationreperfus injuri via inhibit akteno signal pathway myocardi ischemiareperfus ir injuri associ poor outcom higher mortal myocardi infarct recent studi reveal mir p particip process myocardi ir injuri precis role molecular mechan mir p myocardi ir injuri remain well studi ferroptosi propos promot cardiomyocyt death close associ myocardi ir injuri herein present studi aim explor function mechan mir p regul whether mir p contribut ferroptosi induc cardiomyocyt death respond oxygen glucos deprivationreoxygen ogdr injuri vitro model myocardi ir injuri focus akteno signal pathway result found ferroptosi induc cardiomyocyt death occur accompani increas mir p level ogdr treat hc cell mir p inhibitor amelior ferroptosi induc cardiomyocyt death evidenc increas cell viabil reduc reactiv oxygen speci ros generat lactat dehydrogenas ldh activ malondialdehyd mda fe content regul glutathion gsh glutathion disulphid gssg ratio well glutathion peroxidas gpx protein express hc cell expos ogdr mir p mimic opposit effect addit ogdr led inhibit akteno signal pathway also block mir p inhibitor aggrav mir p mimic furthermor ly inhibitor akteno signal pathway abrog mir p inhibitor induc reduct ferroptosi induc cardiomyocyt death summari find demonstr mir p play central role stimul ferroptosi induc cardiomyocyt death ischemichypox injuri via inhibit akteno signal pathway | D000079403;D035683;D015428 | T123;T046;T114;T043 |
36,254,847 | recent progress surfac enhanc raman spectroscopi base biosensor detect extracellular vesicl extracellular vesicl ev type mediat enabl intercellular communic moreov ev carri critic molecular inform parent cell make ideal biomark clinic screen diagnosi current sever sens technolog establish sensit detect ev among surfac enhanc raman spectroscopi ser becom power analyt tool high sensit low detect limit review first cover biolog characterist ev principl ser amplif describ recent progress ser technolog appli detect ev includ direct label free method indirect label strategi substrat fabric nanoprob assembl emphas furthermor ser technolog could also use character monitor behavior programm ev final discuss prospect issu address develop ser technolog ev analysi | D000067128;D015374 | T026;T059;T075 |
36,254,835 | mitochondri dna mainten drosophila melanogast mitochondri dna mtdna encod gene involv oxid phosphoryl intramitochondri protein synthesi sever nuclear encod gene involv mtdna replic transcript repair recombin conserv fruit fli drosophila melanogast mammal addit easi genet tractabl made drosophila use model understand anim mtdna mainten human mtdna diseas howev key differ drosophila mammalian system featur divers mtdna mainten process insid anim cell review known mtdna mainten drosophila highlight area research warrant provid perspect preliminari silico vivo analys tissu specif mtdna mainten process model organ result suggest new role lack thereof well known mainten protein helicas twinkl accessori subunit dna polymeras drosophila gene product may even aid shed light mtdna mainten anim hope provid reader interest path taken help communiti show drosophila may impact futur mtdna mainten research | D004272;D029721 | T123;T116;T114 |
36,254,833 | design synthesi fungicid activ novel plant elicitor base divers orient synthesi strategi novel plant elicitor benzyl oxo phenyl oxaspiro dec en yl ethyliden aminoimidazolin one deriv design base divers orient synthesi strategi synthes four step via knoevenagel condens reaction key step character h nmr c nmr hr esi ms x ray diffract posit cn bond z e configur compound determin x ray diffract vivo fungicid activ evalu reveal compound exhibit remark activ pseudoperonospora cubensi gml among compound e still exhibit excel protect activ inhibit rate gml vitro effect test phytopathogen poor mechan induc immun respons reinforc resist cucumb botryti cinerea studi result indic compound e mediat defens respons b cinerea base accumul pathogenesi relat protein cell wall reinforc callos deposit quantit analysi salicyl acid sa jasmon acid ja increas express induc resist relat gene defens associ phenylalanin ammonia lyas reveal immun respons trigger compound e high associ sa signal pathway signific upregul ja relat gene cs ao indic ja signal pathway also influenc also shown plant treat compound e promot primari root elong result enhanc plant growth import compound complet new structur compar tradit plant elicitor research e mediat plant diseas resist might great influenc develop plant elicitor | D010650;D054883 | T121;T126;T116;T109 |
36,254,831 | synthesi multifunct poli carbamoyl ester contain dual cleavabl linkag aie luminogen via passerini type multicompon polymer conduct passerini type multicompon polymer p mcps various monom afford seri function poli carbamoyl ester pces demonstr effici divers facil approach p mcps produc novel pces dual cleavabl linkag ester disulfid group aggreg induc emiss aie luminogen tetraphenylethylen tpe | D011108;D053758 | T104;T122;T073 |
36,254,828 | traumat disloc knee traumat disloc knee rare orthopaed injuri often sever concomit damag addit ligament injuri signific risk vascular injuri potenti limb threaten undiagnos late recogn therefor crucial correct safe diagnost method acut phase disloc caus high low veloc mechan obes singl risk factor low veloc knee disloc nerv vascular damag disloc associ numer intra extraarticular injuri argu review | D004204;D031221;D057772 | T037 |
36,254,827 | bullous skin diseas review find topic corticosteroid system corticosteroid mainstay initi treatment bullous pemphigoid pemphigus diseas addit immunomodulatori therapi methotrex azathioprin mycophenolatmofetil ad earli treatment minim advers effect chronic corticosteroid therapi augment improv diseas rituximab first line immunomodulatori treatment moder sever pemphigus diseas | D001327;D010392;D012872 | T047 |
36,254,826 | fractur relat infect fractur relat infect fri challeng complic high risk devast outcom patient diagnos fri often difficult treatment frequent requir effort multidisciplinari team recent intern consensus group expert various scientif medic organis publish standardis guidelin diagnosi treatment review provid summari latest studi general principl respect diagnosi treatment aftercar patient fri | D050723;D013530 | T046;T037 |
36,254,825 | spinal cord ischaemia rare form stroke case report spinal cord ischaemia sci year old woman known cerebrovascular risk factor sci rare entiti debilit consequ typic present acut pain correspond involv cord level follow flaccid paralysi decreas sensat autonom dysfunct common caus aortic atheromatosi progress symptom normal cerebrospin fluid analysi mri key import diagnosi entiti yet latter initi normal anticoagul therapi initi treatment choic follow long term rehabilit | D020760;D020521 | T047;T050 |
36,254,821 | hsa templat self generat gold nanoparticl tumor vaccin deliveri combin therapi drug deliveri system dds play vital role construct tumor vaccin promot therapeut effect take advantag versatil bind site bioreduct abil human serum albumin hsa au ion could absorb reduc nucleat generat gold nanoparticl aunp hsa without complic intermedi form dds transform light heat design self generat aunp templat hsa hsa aunp hsa aunp deliv peptid amplifi immun respons achiev combin phototherm therapi immunotherapi human melanoma antigen gp hgp peptid common hydrophil tumor vaccin peptid easili encapsul hsa chosen incorpor hsa aunp vitro vivo studi demonstr nanoparticl mediat light heat transduct near infrar irradi nir achiev tumor ablat enhanc antitumor immun design insul toxic agent streamlin flux increas transit effici interact improv product yield contribut novel modal facil green synthesi nanovaccin | D019496;D053768;D009369 | T129;T121;T116;T073;T191 |
36,254,814 | tmemb promot prolifer migrat invas inhibit apoptosi hypopharyng squamous cell carcinoma sever member transmembran protein famili associ biolog process human malign howev express pattern biolog function one famili member tmemb hypopharyng squamous cell carcinoma hpscc fulli understood express hpscc tumour adjac normal tissu determin immunohistochemistri ihc bioinformat analysi perform verifi express pattern tmemb cancer genom atlas tcga gene express omnibus geo databas furthermor vitro assay cell prolifer invas migrat vivo experi tumour growth apoptosi tmemb hpscc perform found hpscc tissu signific higher express tmemb adjac normal tissu bioinformat analysi confirm differ express tmemb express hpscc furthermor vitro vivo experi demonstr tmemb promot hpscc cell growth cell invas migrat fadu cell wherea flow cytometri assay show tmemb inhibit cell apoptosi studi reveal first time tmemb might serv oncogen function hpscc could potenti diagnost biomark therapeut target hpscc | D007012;D002294;D006258 | T191 |
36,254,802 | gastric digest cow milk almond milk oat milk rat studi gastric digest isocalor iso macronutri cow milk almond milk oat milk compar rat euthan differ post feed time cow milk separ curd phase liquid phase rat stomach coagul cow milk led higher p protein lipid retent stomach compar almond milk oat milk almond milk oil bodi aggreg cream rapid layer stomach induc faster p gastric empti protein min compar cow milk min oat milk min slower gastric empti almond lipid almond protein contrast signific physic chang digest oat milk found protein lipid steadili empti stomach vivo studi provid inform gastric digest empti therebi nutrit characterist plant base milk compar anim base milk use design novel plant base drink | D008892;D000068181 | T168;T002;T031 |
36,254,792 | potenti intermediaci phibr bromin agent phibr first purport exist year ago subject report due low stabil howev recent public propos reaction pifa phi oc cf tmsbr form phibr situ demonstr efficaci aryl bromin report investig synthesi replic bromin reaction claim use situ phibr describ spectroscop comput result indic format phi br br respons bromin support evid invok phibr intermedi found | D054879 | T068;T070;T067 |
36,254,783 | consumpt barley flour increas gut ferment improv glucos intoler via short chain fatti acid receptor gpr obes male mice barley consumpt expect increas insulin sensit increas level short chain fatti acid scfas promot secret glp howev involv gpr receptor scfas investig therefor evalu whether inhibitori effect glucan rich barley intak blood glucos rise mediat gpr signal via increas scfas cblj mice gpr knockout mice fed high fat diet either cellulos hc glucan rich barley flour hb week level scfas cecum content measur concentr glp portal vein determin supernat cecum content cblj mice ad glutag cell chang glp intracellular ca concentr determin paramet measur use cell gpr knock sirna cblj mice fed hb diet show suppress glucos rise compar hc diet cecum scfas glp concentr portal vein also increas hb diet aqueous solut cecum content mice fed hb diet ad glutag cell glp secret intracellular ca concentr increas phenomena observ cell knockdown gpr gpr knockout mice increas glp portal vein suppress blood glucos elev attenu despit increas scfas brought hb diet conclus gpr activ intestin tract via increas scfas requir glucos intoler improv effect barley consumpt | D018149;D001467;D047071 | T121;T109;T168;T047;T002 |
36,254,781 | knowledg attitud associ factor use district health inform system among healthcar provid illu aba bora zone south west ethiopia sound reliabl health inform need promot cultur evid base decis make aim studi assess knowledg attitud healthcar provid use district health inform system among public health facil south west ethiopia | D063005;D007722;D006282 | T053;T170;T097 |
36,254,770 | visual hocl brain alzheim diseas model use easili avail two photon fluorogen probe inflammatori signal molecul hypochlor acid hocl generat myeloperoxidas mpo catalysi associ neuron cell death neuroinflamm etiolog alzheim diseas ad thus signific employ effect tool vivo map hocl earli patholog ad studi propos use easili avail two photon fluorogen probe name q hocl specif sensit detect hocl ad brain q hocl probe display favor select rapid respons hocl limit detect nm addit q hocl probe manifest splendid abil penetr blood brain barrier subsequ util visual hocl fluctuat induc lps pc cell via two photon imag import monitor elev level hocl ad brain compar normal brain ultim base two photon imag hippocampus brain slice morri water maze test cognit abil ad model mice effectu amelior treatment mpo inhibitor thus expect q hocl probe appli reveal capac hocl ad patholog develop efficaci mpo inhibitor drug treatment ad | D006997;D000544 | T047;T196;T048;T197 |
36,254,754 | simplifi hybrid two anticanc bistetrahydroisoquinolin alkaloid ecteinascidin cribrostatin inhibitori activ prolifer cancer cell ecteinascidin famous marin drug use anticanc treatment work seri simplifi hybridsanalogu synthes employ newli develop chemistri integr partial structur featur two anticanc bis tetrahydroisoquinolin alkaloid ecteinascidin cribrostatin describ suzuki coupl protocol enabl us easili introduc variabl function c posit basic skeleton bis tetrahydroisoquinolin alkaloid first time cytotox examin show analogu f exhibit inhibitori activ ic valu low rang prolifer cancer cell line hepg mda mb work reveal diversifi cc olefin skeleton tetrahydroisoquinolin alkaloid use mean generat potenti pharmaceut | D044005;D000470;D000970;D009369 | T121;T123;T109;T131;T191 |
36,254,743 | structur elucid isomer differentiationquantit monophosphoryl phosphoinositid use gas phase ionion reaction dissoci kinet phosphoinositid phosphoryl deriv phosphatidylinositol essenti signal phospholipid mammalian cellular membran three known phosphoryl deriv phosphatidylinositol posit along myo inositol ring various fatti acyl chain length vari degre unsatur numer isom present challeng shotgun ms accur identifi character phosphoinositid isom use readili avail precursor ion type overcom challeng novel gas phase ionion chemistri use expand rang precursor ion type subsequ structur character phosphoinositid use shot gun tandem mass spectrometri degre phosphoryl fatti acyl sum composit readili obtain ion trap cid deproton phosphoinositid carbon carbon doubl bond posit fatti acyl chain local via charg invers ionion reaction util sequenti ionion reaction subsequ activ yield product ion inform limit util phosphoryl site local howev kinet dissoci allow isomer differenti posit phosphat group furthermor employ kinet method relat quantit inform gain isomer speci | D010716;D053719 | T063;T123;T109 |
36,254,733 | transurethr renal pelvic denerv feasibl trial patient uncontrol hypertens endovascular renal denerv reduc blood pressur bp explor altern approach renal denerv use radiofrequ energi deliv across renal pelvi util natur orific urethra uret | D013562;D006973 | T061;T047 |
36,254,732 | effect interv neoadjuv chemoradiotherapi surgeri diseas recurr surviv rectal cancer long term result random clinic trial optim time surgeri follow chemoradiotherapi crt controversi trial aim assess diseas recurr surviv rate patient local advanc rectal adenocarcinoma larc underw total mesorect excis tme wait interv week less classic interv ci versus week long interv li follow preoper crt | D020360;D012004 | T061;T191 |
36,254,731 | chang pattern multidisciplinari team treatment earli mortal surviv colorect cancer studi report earli mortal surviv colorect cancer relat pattern treatment deliv multidisciplinari team mdt meet high volum institut england year | D015179 | T191 |
36,254,729 | coval organ framework construct step step use c c c strategi toward fluoresc detect fe seri new coval organ framework cof construct step step use c c c strategi first time show select fluoresc detect properti toward fe ion lowest limit detect lod fluoresc quench main attribut absorpt competit quench acq mechan | D000073396 | T109 |
36,254,715 | predictor chang hypoglycemia unawar among patient type diabet analys predictor hypoglycemia unawar hu improv clark score clinic practic | D003922;D007003;D048909 | T047 |
36,254,714 | synthesi dihydropyrrol situ generat zwitterion via rh adc tbai dual catalysi trigger format imino carben regioselect synthesi dihydropyrrol achiev via cascad sulfin migrationannul sulfin group convert sulfon group migrat stabl anion bear two electron withdraw group thus form addit catalyt amount iodid believ assist cleavag c bond format stabl carboc thermodynam product dihydropyrrol produc effici rather kinet product cyclopropan dual catalysi system would afford chemist new strategi control annul select zwitterion bear multipl reactiv site may employ flexibl diverg synthesi differ ring system | D011758;D003521 | T121;T109 |
36,254,710 | development program perinat glucocorticoid earli life environment factor persist effect physiolog function alter development procedur various organ recent experiment epidemiolog studi support idea development program also present mammal includ human influenc long term health although mechan program still larg investig role endocrin glucocorticoid development program gain interest studi found perinat glucocorticoid persist effect multipl function bodi includ metabol behavior immun function adulthood sever mechan propos play role long term program review recent find topic summar potenti biolog rational behind phenomenon discuss | D005938;D008322 | T125;T039;T015;T109 |
36,254,709 | singl cell revel thermogen adipos tissu past two decad wit upsurg appreci adipos tissu immuno metabol hub harbour heterogen cell popul collect fine tune system metabol homeostasi technolog advanc especi singl cell transcriptom offer unpreced opportun dissect sophist cellular network composit dynam underpin remodel discoveri function brown adipos tissu dissip heat energi human adult arous tremend interest exploit mechan underpin engag thermogenesi combat human obes review aim summaris evalu use singl cell transcriptom contribut better appreci cellular plastic intercellular crosstalk thermogen | D000273;D004734;D022722 | T201;T039;T040;T024 |
36,254,705 | mechan robust stabl estradiol load phema base hydrogel barrier intrauterin adhes treatment estrogen combin physic barrier therapi may prospect method repair damag endometrium prevent postsurg adhes treatment intrauterin adhes iua lack suitabl scaffold good biocompat appropri mechan properti drug releas kinet herein mechan robust stabl barrier base poli hydroxyethyl methacryl phema hydrogel combin estradiol load mesopor silica design network form coval bond noncoval coordin bond endow hydrogel superior mechan properti report phema base hydrogel meanwhil coval bond impart excel stabil hydrogel maintain structur mechan properti simul uterin fluid day excel mechan properti stabil compar typic barrier materi intrauterin devic iud enabl hydrogel retain uterus remov intact like iud vitro vivo experi show hydrogel possess good biocompat similar pure phema hydrogel addit hydrogel releas estradiol continu stabli exhibit good therapeut effect promot prolifer endometri cell inhibit progress fibrosi therefor combin advantag make present hydrogel promis iua treatment | D011102;D004958 | T125;T121;T122;T109 |
36,254,704 | new mechan kidney protect effect alkali chronic kidney diseas worldwid one ten adult estim chronic kidney diseas ckd ckd progress cost treatment associ risk morbid mortal increas exponenti great need therapi effect slow ckd progress evid sever small clinic trial indic alkali therapi may slow rate ckd progress biolog mechan under protect effect howev remain unknown recent publish manuscript pastor arroyo et al clin sci lond https doiorgc demonstr alkali sodium bicarbon protect loss renal function crystal nephropathi model mice use unbias approach mice human tissu author go identifi two novel mechan may under protect first pathway promot pathway cell metabol specul help remain function nephron adapt greater metabol need requir maintain kidney filtrat second pathway restor klotho level may limit express adhes molecul injur kidney author specul may prevent inflamm drive function declin kidney identifi novel pathway repres import step forward har potenti benefit alkali therapi ckd | D051436;D017693 | T121;T047;T109 |
36,254,703 | macauba acrocomia aculeata kernel good protein qualiti improv lipid profil short chain fatti acid content wistar rat macauba acrocomia aculeata arous interest food industri due high nutrit valu fruit studi aim evalu protein qualiti influenc biochem marker short chain fatti acid content intestin morpholog intestin function wistar rat macauba kernel male young rat divid three group n receiv control diet casein two test diet semi defat macauba kernel flour semi defat macauba kernel flour day protein effici ratio per net protein ratio npr true digest td biochem intestin morpholog function marker evalu per npr valu lower test group compar control group td differ anim fed macauba kernel flour lower concentr total cholesterol triglycerid compar control group concentr acet propion acid higher fecal ph lower group compar control group gene express aminopeptidas ap sodium glucos transport protein sglt differ among group group lower express peptid transport pept sucras isomaltas si control group crypt thick higher group compar group intestin muscl layer width differ among group therefor macauba kernel flour prove good plant protein altern consumpt reduc blood lipid increas short chain fatti acid content | D028023 | T002 |
36,254,685 | molecular dynam simul solid state nuclear magnet reson spectroscopi measur c h bond order paramet effect correl time popc gm bilay glycolipid gangliosid affect properti lipid membran extens interact membran biomolecul like protein better understand properti individu lipid molecul contribut shape function aspect membran spatial restrict dynam c h bond segment measur use nuclear magnet reson nmr spectroscopi combin solid state nmr spectroscopi atom molecular dynam md simul investig gangliosid gm affect bilay structur dynam c h bond segment two method yield reorient correl function molecular profil c h bond order paramet ch effect correl time e compar lipid popc bilay without mol gm result reveal c h segment popc reorient slower presenc gm defin featur gm popc bilay lie gm headgroup give bilay extend headgroup layer high order ch slow dynam e ns charact may mechanist import gangliosid interact biomolecul | D056004;D008051 | T026;T066;T044 |
36,254,682 | lipopolysaccharid distinct alter human microglia transcriptom resembl microglia alzheim diseas mous model alzheim diseas ad common form dementia risk influenc genet implic microglia neuroimmun pathogenesi ad induc pluripot stem cell ipsc deriv microglia ipsc microglia increas use model ad relev histor immun stimuli model ad unclear perform detail cross comparison time effect combinatori stimul ipsc microglia particular relev ad use singl cell rna sequenc measur transcript respons ipsc microglia h h stimul prostaglandin e pge lipopolysaccharid lps interferon gamma ifn either alon combin atp observ share core transcript respons ipsc microglia atp lpsifn suggest converg mechan action across condit observ signific overlap although direct inconsist gene chang express level human microglia ad patient use data led approach identifi common axi transcriptom chang across ad genet mous model microglia show lps provok transcript respons along axi mous microglia lpsifn human ipsc microglia articl associ first person interview first author paper | D000544;D017628 | T047;T025;T048 |
36,254,678 | combin molecular dynam simul dft studi mercapto benzamid inhibitor hiv ncp protein molecular dynam quantum simul perform elucid aspect action mechan mercapto benzamid propos class antivir hiv molecul act prodrug modif biolog environ abl denatur hiv nucleocapsid protein metal binder protein two zinc finger motif vital rna matur viral replic despit attract featur molecul biolog target well understood simul perform support propos action mechan base activ mercapto benzamid acetyl target relat rare protein hydrolyz state follow tran molecular acetyl molecul protein final direct interact molecular sulphur atom mercapto benzamid zinc atom coordin protein simul result agreement nmr data zinc finger bind protein equilibrium configur | D015497;D015658 | T005;T047 |
36,254,677 | sx noncoval interact revisit new benchmark perform composit local coupl cluster method sx noncoval interact benchmark evalu sterl silver level use explicit correl mp f near complet basi set limit ccsd f aug cc pvtz f correct convent ccsd sano v z calcul revis refer valu differ kcal mol rms origin hobza benchmark revis brauer et al kcal mol rms bronz level data kesharwani et al aust j chem use assess perform local orbit coupl cluster approach without counterpois correct pno lccsd implement molpro dlpno ccsd implement orca lno ccsd implement mrcc respect normal tight tight set also consid composit approach combin differ basi set cutoff furthermor order isol basi set converg domain truncat error aug cc pvtz basi set compar pno dlpno lno approach canon ccsd conclud lno ccsd verytight criteria perform well raw cp uncorrect struggl reproduc counterpois correct number even veryverytight criteria mean accur result obtain use either extrapol basi set larg enough quench basi set superposit error bsse aug cc pv q z use composit scheme tight q vvtight tight contrast pno lccsd work best counterpois perform without counterpois compar dlpno ccsd among econom method highest accuraci seen drpa dbj bm v bm revdsd pbep dft sapt tdexx atdexx kernel | D019985 | T081 |
36,254,669 | bioprint base autom deposit singl cancer cell spheroid oxygen sensor microelectrod well three dimension cell agglomer microtissu organoid spheroid becom increas relev biomedicin provid vitro model recapitul function origin tissu bodi applic cancer research exampl wide use organ chip system microsensor provid essenti real time inform cell metabol well reliabl qualiti cultur condit combin sensor cell cultur especi singl spheroid challeng term reproduc format manipul access spheroid precis posit near sensor high cell volum ratio obtain meaning biosign parallel approach possibl overcom challeng combin state art bioprint techniqu automat print tumour spheroid direct microwel chip base electrochem oxygen sensor array demonstr high accur reproduc spheroid format diamet approx spheroid deposit precis within volum nl per droplet microstructur hydrogel coat microwel allow placement singl mcf breast cancer spheroid close sensor electrod microelectrod well seal oxygen measur within nl volum fast concentr chang accur stabl amperometr oxygen sensor perform demonstr atmospher anox region cellular respir rate singl tumour spheroid rang fmol min determin alter cell metabol upon drug exposur shown result uniqu combin bioprint cell cultur monitor demonstr much need effort facilit parallel sensor integr drug deliveri cell cultur organ chip experi workflow high degre autom potenti scalabl order achiev greater flexibl autom spheroid format trap employ method base drop demand liquid handl system instead typic chip approach common use microfluid relev rang fundament metabol research standard cell cultur experi toxicolog studi person medicin eg patient specif chemotherapi | D062028;D009369 | T063;T191 |
36,254,668 | degrad hydrogel bead detect serum bicarbon level diagnosi metabol alkalosi point care work present novel point care hydrogel base diagnost devic rapid detect elev bicarbon level serum diagnosi mild sever case metabol alkalosi system consist hydrogel bead compos calcium algin nonion polym dextran assay util reaction sodium bicarbon citric acid produc citrat metal chelat capabl competit bind calcium cation gel matrix trigger hydrogel degrad result success detect elev bicarbon concentr less one hour specif critic high bicarbon concentr mmol l human serum detect littl min respect demonstr assay feasibl use resourc limit set develop simpl electron devic achiev similar result could use untrain individu lab equip minim power knowledg first demonstr use nonion polym synthes improv morpholog calcium algin hydrogel bead use simpl process method involv minim labor equip simplifi bead synthesi protocol combin user friend devic allow rapid detect metabol alkalosi point care | D001639;D000471 | T047;T121;T196;T197 |
36,254,663 | evolut mechan femo alloy catalyst growth singl wall carbon nanotub ad small fraction mo fe nanoparticl nps reduc melt point femo nps lower fe nps prolong lifetim alloy catalyst turn promot qualiti catalyt synthes singl wall carbon nanotub swcnts studi reveal mechan mention abnorm melt behavior employ molecular dynam simul result indic bond length fe atom number bond mo atom play import role reduc melt point femo nps studi provid use insight evolut mechan alloy catalyst growth swcnts | D037742;D053758 | T104;T073 |
36,254,657 | surgeri skull base new section acta otorhinolaryngologica italica la chirurgia della base del cranio una nuova sezion di acta otorhinolaryngologica italica | D019291;D019292 | T191;T029 |
36,254,656 | superior temporo auricular perfor flap reconstruct extens conchal defect il lembo perforant temporo auricolar superior per la ricostruzion dei difetti estesi della conca | D054644;D061525;D019651 | T061;T023 |
36,254,655 | paediatr otogen sinus venous thrombosi role fusobacterium necrophorum sinus venous thrombosi svt rare complic acut otiti media aom acut mastoid recent year associ fusobacterium necrophorum fn infect object review clinic microbiolog hematolog featur paediatr otogen svt specif focus role fn | D005674;D008417;D010033;D020246 | T047;T046 |
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