PMID int64 35.7M 36.4M | Title/Abstract stringlengths 22 8.78k | MeshTerms stringlengths 7 101 | SemanticTypes stringlengths 4 64 |
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36,251,027 | complex posttraumat stress disord adult term complex posttraumat stress disord cptsd appear scientif literatur year ago includ diagnost catalogu first time name intern statist classif diseas relat health problem icd offici publish begin usual sever debilit disord often pose great challeng treat physician psychotherapist everyday clinic practic due much debat overlap cptsd borderlin person disord bpd high case comorbid bpd ptsd cptsd becam embroil scientif discuss raison dtre bpd new dimension concept person disord pd icd addit detail explan diagnost criteria cptsd differenti mental disord particular ptsd bpd dissoci disord articl summar histor develop concept cptsd date current avail treatment option criteria appli cptsd childhood adolesc adulthood special featur address articl | D013313;D001883 | T048 |
36,251,013 | effect radiotherapi local control tn rectal cancer manag total mesorect excis meta analysi total mesorect excis tme signific improv rectal cancer outcom radiotherapi benefit tn rectal cancer patient manag tme clear demonstr systemat review meta analysi undertaken determin whether radiotherapi alter risk locoregion recurr lr tn rectal cancer patient manag tme | D009364;D012004 | T191 |
36,251,009 | azol auxiliari intermedi prebiot nucleosid synthesi dicyanoimidazol aminothiazol azol previous implic prebiot nucleotid synthesi former compound byproduct adenin synthesi latter compound shown capabl separ c c sugar via crystal amin report elus intermedi cyanoacetylen captur dicyanoimidazol accumul crystallin compound n cyanovinyl dicyanoimidazol thus provid solut problem concentr atmospher form cyanoacetylen import intermedi compet cyanoacetylen surrog react ribo aminooxazolin formamid give ribo anhydrocytidin intermedi diverg synthesi purin pyrimidin nucleotid also report prebiot plausibl synthesi aminothiazol examin mechan format util azol enhanc prebiot synthesi ribonucleotid synthes comport cyanosulfid scenario previous describ | D009705;D001393 | T121;T114;T109 |
36,251,005 | potenti energi weight reactiv flux total rate chang potenti energi theori illustr applic reactiv flux larg nonzero nonequilibrium ensembl trajectori provid insight inform reactiv transit reactant state product state base reactiv flux theoret framework propos two quantiti potenti energi weight reactiv flux total rate chang potenti energi use identif mechan nonequilibrium ensembl quantiti two multidimension free energi analogu deriv subspac collect variabl equival region reactiv flux diverg free free energi analogu assum close relat free energi subspac collect variabl reduc one dimension case ensembl averag potenti energi weight reactiv flux intens propos recent li w j phys chem doi acsjpcac could decompos energi compon per coordin level subspac collect variabl decomposit multidimension free energi analogu per coordin level theoret possibl numer difficult calcul interest total rate chang potenti energi abl identifi locat transit state ensembl stochast separatrix addit locat reactant product state total rate chang potenti energi decompos per coordin level compon quantifi contribut coordin reactiv transit subspac collect variabl illustr main insight object provid approach applic two dimension system various diffus anisotropi alanin peptid vacuum various nonequilibrium ensembl short trajectori result found consist | D000409 | T123;T121;T116 |
36,251,002 | acetyl group migrat xylan glucan model compound studi experiment comput method recent demonstr us acetyl group oligosaccharid migrat within one saccharid unit also two differ saccharid unit kinet phenomenon previous investig mannan model compound natur occur polysaccharid addit mannan also sever natur acetyl polysaccharid xyloglucan xylan xyloglucan xylan common acetyl polysaccharid natur display import role plant cell consid various biolog role natur polysaccharid could hypothes intramolecular migrat acetyl group might also associ regul biolog activ polysaccharid natur consequ better understand overal migrat phenomenon across glycosid bond could help understand potenti role migrat context biolog activ polysaccharid present detail investig acetyl group migrat synthes xylan glucan trisaccharid model compound combin experiment comput method show migrat saccharid unit proceed secondari hydroxyl group one saccharid unit toward primari hydroxyl group unit | D014990;D005936 | T121;T109 |
36,251,000 | pursu phase transit concentr polym solut situ fluoresc measur base aggreg induc emiss concentr depend phase transit concentr solut remain specul due serious impedi macromolecul dynam intens topolog entangl intermolecular interact well absenc power tool detect chang chain segment movement herein take general polym name poli vinyl alcohol pva exampl water solubl fluoresc molecul aggreg induc emiss aie introduc pva solut chain dynam indic investig phase transit high concentr situ monitor solvent evapor process two turn point fluoresc intens observ first time mean concentr correspond gelat amorph crystallin transit respect work offer fundament insight physic natur concentr depend nonequilibrium transit develop reliabl sensit approach base aie phenomenon follow high concentr trigger properti chang polym solut | D011108;D011142 | T104;T122;T121;T109 |
36,250,999 | caffeic acid graft plga novel materi design fluvastatin elut nanoparticl prevent neointim hyperplasia drug elut nanoparticl nps administ elut balloon repres novel tool prevent restenosi angioplasti even select suitabl drug biodegrad materi still matter debat herein provid proof concept use novel materi obtain combin graft caffeic acid resveratrol poli lactid co glycolid backbon g ca plga g rv plga pleiotrop effect fluvastatin chosen low lipophil profil challeng encapsul nps deliveri arteri wall cell nps made materi biocompat macrophag human smooth muscl cell smcs endotheli cell ec cellular uptak demonstr quantifi confoc microscopi use fluoresc nps distribut cytoplasm verifi tem imag use nps stain ag pvp probe apposit synthet g ca plga assur best control flv releas np size around nm faster smc uptak demonstr confoc analys interest surpris g ca plga improv flv efficaci inhibit smc migrat without alter effect ec prolifer migrat improv trophism nps toward smcs combin excel biocompat low modif microenviron ph upon polym degrad make g ca plga suitabl materi design drug elut balloon | D011100;D053758 | T122;T073;T109 |
36,250,998 | progress experiment induc gingiv peri implant mucos present common featur systemat review clinic human studi systemat review evalu featur progress experiment induc gingiv peri implant mucos human includ studi evalu clinic immunolog microbiolog respons experiment induc gingiv peri implant mucos periodont healthi patient total articl initi identifi includ final analysi implant accumul less biofilm suffer heterogen alter microbiota abstin oral hygien compar tooth interest although dental implant present less biofilm accumul peri implant mucosa show exacerb clinic respons gingiv tissu risk bias select studi moder low one studi present serious risk progress event peri implant mucos similar experiment gingiv led differ host respons review regist prospero databas crd | D052016;D057873;D005891;D015921 | T047;T046;T074 |
36,250,984 | tip balanc toward stem trophoblast metabol program coxb metabol effector drive cell fate emerg concept stem cell biolog show cytochrom c oxidas subunit b coxb essenti maintain stem trophoblast stem ts cell rna interfer coxb result decreas mitochondri complex iv activ atp product oxygen consumpt rate ts cell furthermor deplet coxb ts cell led decreas self renew capac indic compromis brdu incorpor ki stain decreas express ts cell genet marker expect consequ coxb knockdown induct differenti ts cell stem factor cdx transactiv coxb promot ts cell differenti cell coxb post transcript regul two microrna mir p mir p lead downregul demonstr gain loss function mirna coxb transcript gradual rise placent trophoblast gestat progress mice rat predomin express labyrinthin trophoblast coxb express compromis growth restrict placenta rat reciproc regul mir p mir p data highlight import coxb regul ts cell state uncompromis placent growth | D035683;D014327 | T123;T018;T114 |
36,250,975 | dexmedetomidin attenu renal ischemia reperfus injuri activ pikakt eno signal via adrenoreceptor renal microvascular endotheli cell renal microvascular endotheli cell rmec close relat regul vascular reactiv modul inflamm play crucial role process renal ischemia reperfus ir injuri previous studi report protect effect dexmedetomidin dex renal ir injuri littl known role dex rmec studi aim investig whether dex allevi renal ir injuri via act rmec mice underw bilater renal arteri clamp min follow reperfus h cultur neonat mice rmec subject hypoxia h follow reoxygen hr h result suggest dex allevi renal ir injuri vivo improv cell viabil rmec hr injuri vitro gene sequenc reveal pikakt top enrich signal pathway endotheli cell wide involv renal ir injuri dex activ phosphoryl pik akt increas eno express attenu inflammatori respons addit result confirm distribut adrenoreceptor ar rmec furthermor protect effect dex renal ir injuri abolish ar antagonist atipamezol part revers pik agonist p find indic dex protect renal ir injuri activ pikakt eno pathway inhibit inflamm respons via ar rmec | D020927;D015427 | T121;T037;T109 |
36,250,974 | genet predict high igf level show protect effect covid suscept hospit mendelian randomis studi data studi across countri epidemiolog studi observ gender differ covid outcom howev whether sex hormon play causal covid risk remain unclear studi aim examin associ sex hormon sex hormon bind globulin shbg insulin like growth factor igf covid risk | D000086382;D055106 | T063;T047;T067 |
36,250,972 | anim qualiti pursuit relev nation institut health advisori committe director acd announc recommend improv reproduc biomed research use anim respons jackson laboratori faculti institut leader identifi key strategi address import issu take inspir evolut clinic trial recent decad respons similar challeng identifi opportun improv includ establish common standard use genet divers popul requir robust studi design appropri statist method improv public databas facilit meta analys perspect share respons acd recommend specif focus mous model aim promot continu activ dialogu among research use anim system worldwid discuss help inform biomed communiti recommend support much need implement | D035843 | T062 |
36,250,966 | metabol label cardiomyocyt deriv small extracellular vesicl sev mirna identifi mir cardiac regul lung gene express toxoplasma gondii uracil phosphoribosyltransferas uprt convert thiouracil tuc thiouridin tud incorpor nascent rnas biotinyl label streptavidin conjug isol via streptavidin affin method generat mice express gondii uprt cardiomyocyt cm uprt mice test hypothesi cm deriv mirna cm mir transfer remot organ myocardi infarct mi small extracellular vesicl sev releas heart peripher blood pb sev found tud incorpor high specif sensit rnas isol heart pb sev cm uprt mice h tuc inject pb sev tud incorpor cm specificenrich mir includ mir mir organ tissu type specif tud label mira also present lung tissu especi lung endotheli cell ec cm deriv mir cm mir level peak h experiment induc mi pb sev h mi lung notabl mir express intron myosin heavi chain mhc mhc transcript near undetect lung pb sev mice underw mi mi pb sev sham surgeri sham pb sev inject intact mice express tmbim nlk suppress mir cooper regul inflamm via nf b pathway lower lung mi pb sev treat anim lung anim treat sham pb sev salin mi mice tmbim nlk downregul wherea endotheli adhes molecul pro inflammatori cell upregul lung chang signific attenu mice treat mir antagomir prior mi surgeri thus cm uprt mice enabl us track pb sev mediat transport cm mir identifi mir mediat mechan myocardi injuri alter express gene inflammatori respons lung | D000067128;D035683;D009203 | T026;T123;T047;T114 |
36,250,963 | earli immedi gene egr associ tgf regul epigenet reader bromodomain contain protein via canon smad signal hepat stellat cell vitro vivo upon chronic damag liver multipl cytokin stimul hepat stellat cell hscs caus alter gene express profil thus lead hsc activ key step liver fibrogenesi activ hscs domin contributor liver fibrosi bromodomain contain protein brd import epigenet reader demonstr concentr hundr enhanc associ gene involv multipl profibrot pathway therebi direct hsc activ fibrot respons present studi design examin effect transform growth factor beta tgf potent pro fibrot cytokin brd express hscs elucid under mechan vitro vivo experi employ heterogen tgf knockout tgf mice gene knockdown vivo model thioacetamid taa induc liver injuri result reveal tgf enhanc brd express hscs mediat least smad signal earli immedi gene egr earli growth respons tgf induc smad signal increas egr express promot egr bind brd promot site around bp promot brd express egr knockdown reduc brd express hscs mous model taa induc liver injuri lessen liver fibrosi doubl fluoresc stain demonstr strong increas brd express activ hscs fibrot area human liver parallel upregul p smad egr research suggest novel molecular event under role master pro fibrot cytokin tgf hsc activ liver fibrogenesi | D056487;D051766;D055166;D009687;D014157 | T123;T047;T116;T025 |
36,250,954 | arylbor enecarbam synthesi boryl satur n heterocycl two catalyt system develop arylbor endocycl enecarbam deliv synthet versatil boryl satur n heterocycl good regio diastereoselect cupd dual catalyt reaction enabl synthesi boryl aryl azetidin ni catalys arylbor reaction effici function member enecarbam case cupd system remark addit effect identifi allow broader scope product synthet use demonstr manipul boron ester access biolog activ compound | D001895;D004952 | T196;T109 |
36,250,950 | circbgn acceler gastric cancer cell prolifer invas via activ ilstat signal pathway circular rnas particip pathogenesi various tumor includ gastric cancer gc studi investig role circbgn regul prolifer invas gc cell elucid mechan express circbgn assess quantit revers transcript pcr situ hybrid addit loss gain function investig vitro vivo perform determin biolog function circbgn luciferas report assay rescu experi appli investig interact circbgn mir p well relationship mir p il result show circbgn express signific elev gc tissu cell knockdown circbgn dramat suppress gc cell prolifer invas vitro xenograft experi reveal knockdown circbgn delay tumor growth vivo furthermor circbgn direct bind mir p therebi prevent mir p bind target mrna il mrna thus activ ilstat signal pathway rescu assay indic circbgn regul gc cell prolifer invas upregul mir pil axi output taken togeth investig indic circbgn support gc progress activ ilstat signal pathway thus point new possibl therapeut target gc | D035683;D013274 | T123;T191;T114 |
36,250,941 | liquid liquid phase separ mediat format herpesvirus assembl compart virus assembl take place late stage viral replic essenti virus propag howev under mechan remain poor understood especi virus complic structur use correl light electron microscopi examin format cytoplasm virion assembl compart cvac infect herpesvirus cvac membraneless organell liquid like properti format cvac virus infect mediat orf abund tegument protein orf undergo liquid liquid phase separ llps promot dna rna disrupt orf phase separ block cvac format virion product result demonstr phase separ orf critic cvac format work defin herpesvirus cvac membraneless compart generat process llps mediat tegument protein add cellular process facilit phase separ | D014771;D006564;D019065 | T026;T005;T038 |
36,250,940 | forc tune regul clathrin depend integrin endocytosi integrin endocytosi essenti mani fundament cellular process whether intern impact cellular mechan remain elus wherea previous studi report contribut integrin activ talin forc develop involv inhibitor less document identifi icap integrin inhibitor involv mechanotransduct co work nme control clathrin mediat endocytosi integrin edg focal adhes fa loss icap enabl integrin mediat forc generat independ integrin integrin mediat forc associ decreas integrin dynam stem reduc diffus within adhes site slow turnov fa decreas integrin dynam correl defect integrin endocytosi icap act adaptor clathrin depend endocytosi integrin icap control integrin endocytosi interact nme key regul dynamin depend clathrin coat pit fission control clathrin mediat integrin endocytosi inhibitor unpreced mechan tune forc fa | D002966;D004705;D019012;D039661;D022001 | T026;T129;T123;T116;T043 |
36,250,931 | kifb contribut progress interstiti fibrosi via migrat myofibroblast differenti renal fibroblast kinesin famili member b kifb essenti kidney develop delet mice lead kidney agenesi howev role gene adult set remain elus thus studi aim investig role kifb progress renal fibrosi renal fibrosi model adenin administr use kifb heterozyg mice wild type mice establish renal fibrosi under mechan investig under pathway function kifb evalu vitro model use primari renal fibroblast kifb heterozyg mice protect renal fibrosi adenin administr renal express connect tissu growth factor ctgf myofibroblast accumul reduc kifb heterozyg mice express nonmuscl myosin heavi chain ii nmhcii bind c terminus kifb protein also suppress kifb heterozyg mice vitro studi reveal reduc express ctgf smooth muscl actin myosin heavi chain myh via transfect sirna target kifb renal fibroblast rfb rfbs transfect express vector kifb demonstr higher express gene non transfect cell final kifb suppress nmhcii blockag led reduc abil migrat collagen gel contract renal fibroblast taken togeth kifb contribut progress interstiti fibrosi via migrat myofibroblast differenti myh renal fibrosi model blockag pathway appropri time might therapeut approach renal fibrosi | D007668;D016547;D058628 | T123;T116;T025;T126;T023 |
36,250,930 | let bring game univers classroom specif adapt game could great enhanc teach higher educ specif adapt game could great enhanc teach higher educ game play proven effici mean children learn make greater effort use tool univers teach | D007858;D013663 | T061;T090;T062;T065;T041 |
36,250,926 | tantalum metal nineteenth centuri analyt chemistri identif chemic element paper examin identif chemic element use miner analysi focus controversi surround tantalum metal metal tantalum niobium still recognis element today discoveri claim columbium pelopium ilmenium dianium retract refut despit theoret institut chang chemistri underw time debat tantalum metal point toward continu identif metal nineteenth centuri chemist continu use type analyt procedur mid eighteenth centuri predecessor analyt method enabl identif metal base chemic behaviour compound without requir isol form simpl substanc metal accord central question debat tantalum metal correct identif properti compound elimin impur rather simplic new metal stori tantalum metal therefor illustr fact despit definit chemic element simpl substanc discoveri new metal element rare coincid isol new simpl substanc | D013635;D009556 | T196 |
36,250,925 | disturb nlrp acetyl inflammasom assembl inhibit androgen receptor promot inflammatori respons prostat cancer progress chronic inflamm one definit factor lead occurr develop tumor includ prostat cancer pca androgen receptor ar pathway essenti pca tumorigenesi inflammatori respons howev littl known ar regul nacht lrr pyd domain contain protein nlrp inflammasom pathway human pca studi explor express inflammatori cytokin ar high grade pca observ nlrp inflammasom associ gene upregul high grade pca compar low grade pca benign prostat hyperplasia associ ar express addit identifi circar circrna deriv ar gene involv ar regul inflammatori respons cell prolifer activ nlrp inflammatori pathway circar overexpress promot cell prolifer inflammatori respons deplet induc opposit effect mechanist note circar mediat acetyl modif nlrp katb promot nlrp inflammasom complex subcellular distribut assembl disturb nlrp acetyl block inflammasom assembl inhibitor suppress progress pca xenograft tumor find provid first evid target nlrp acetyl inflammasom assembl may effect inhibit pca progress | D011471;D011944 | T191;T116;T192 |
36,250,924 | rna reader igfbp promot metastasi tripl negat breast cancer via slit repress tripl negat breast cancer tnbc group fatal malign character high metastat capac under mechan remain larg elus found insulin like growth factor mrna bind protein igfbp high express tnbc correl clinic distant metastasi free surviv tnbc patient igfbp promot migrat invas capabl tnbc cell depend upon cellular rna n methyladenosin modif mechanist igfbp bind destabil methyl mrna extracellular matrix glycoprotein slit impair downstream signal via cognat receptor robo consequ trigger activ canon pikakt mekerk pathway igfbpslit axi critic involv regul tnbc metastasi vivo find shed light regulatori network distant metastasi breast cancer provid rational target machineri treatment tnbc | D013002;D064726;D016601 | T125;T123;T191;T116 |
36,250,920 | evid fragil x messeng ribonucleoprotein fmr mrna gain function toxic mechan contribut pathogenesi fragil x associ prematur ovarian insuffici fragil x associ prematur ovarian insuffici fxpoi among famili disord caus expans cgg trinucleotid repeat sequenc locat untransl region utr fragil x messeng ribonucleoprotein fmr gene x chromosom women fxpoi deplet ovarian follicl popul result amenorrhea hypoestrogen loss fertil age fxpoi caus expans cgg sequenc length repeat known fmri premut howev mechan premut drive diseas pathogenesi remain unclear two main hypothes exist describ mrna toxic gain function mechan protein base mechan repeat associ non aug ran translat result product abnorm protein call fmrpolyg develop vitro granulosa cell model fmr premut ectop express cgg repeat rna fmrpolyg protein show expand cgg repeat rna accumul intranuclear rna structur aggreg abl caus signific granulosa cell death independ fmrpolyg express use innov rna pulldown mass spectrometri base approach identifi protein specif sequest cgg rna aggreg granulosa cell vitro thus may deregul consequ interact furthermor demonstr reduc express three protein identifi via rna pulldown fus pag tra ovarian follicl fmr premut mous model collect data provid evid contribut mrna gain function mechan fxpoi diseas biolog | D051860;D005600;D008594;D016649 | T123;T047;T116 |
36,250,916 | investig murin host sex biolog variabl epitheli barrier function muscl contractil human intestin organoid intestin failur occur intestin surfac area function suffici support digest nutrient absorpt human intestin organoid hio deriv tissu engin intestin potenti cure research date demonstr success hio transplant thio mice signific vivo matur area lack literatur explor murin host sex biolog variabl sabv thio function studi investig murin host sabv thio epitheli barrier function muscl contractil hio generat vitro transplant nonobes diabet sever combin immunodefici gamma chain defici male femal mice thio harvest week vivo revers transcriptas polymeras chain reaction immunohistochemistri conduct compar tight junction contractil relat marker thio uss chamber contractil apparatus use evalu thio epitheli barrier muscl contractil function respect express morpholog tight junction contractil relat marker thio male femal murin host signific differ epitheli barrier function measur transepitheli resist short circuit current fluorescein isothiocyan dextran permeabl differ thio male femal host although result may limit hio epitheli immatur short flux time muscl contractil measur total contractil activ amplitud frequenc tension signific differ thio male femal host data suggest murin host sex may signific biolog variabl influenc thio function specif epitheli barrier mainten muscl contractil though limit exist model | D003911;D009940 | T123;T121;T024;T109 |
36,250,915 | generat genet modifi pig model crebrf rq variant obes among strongest risk factor type diabet td crebrf missens allel rs p arggln p rq associ increas bodi mass index reduc risk td peopl pacif ancestri investig function consequ crebrf variant introduc correspond human mutat rq porcin genom crebrf rq pig display dramat increas fat deposit main distribut subcutan adipos tissu viscer adipos tissu crebrf rq variant promot preadipocyt differenti increas differenti capac precursor adipocyt confer pig uniqu histolog phenotyp adipocyt smaller size greater number subcutan adipos tissu sat crebrf rq variant pig addit sat crebrf rq pig content peroxid metabolit hydroxi nonen malondialdehyd signific decreas activ antioxid enzym glutathion peroxidas superoxid dismutas catalas increas accord declin level reactiv oxygen speci ros crebrf rq pig togeth data support causal role crebrf rq variant pathogenesi obes part via adipocyt hyperplasia suggest reduc oxid stress adipos tissu may mediat relat metabol protect afford variant despit relat obes | D003924 | T047 |
36,250,902 | protect role car experiment chronic pyelonephr emerg evid suggest car play import role homeostasi host defens diseas although known car protect sever model acut bacteri infect role car chronic infect larg unknown show car protect experiment chronic pyelonephr global car defici car mice higher renal bacteri load pronounc renal histolog lesion increas renal apoptot cell accumul tissu inflamm extracellular matrix deposit follow renal infect uropathogen e coli upec strain ih compar wt control mice myeloid car defici lyz car mice exhibit similar diseas phenotyp global car mice pharmacolog treatment car agonist reduc diseas sever experiment chronic pyelonephr furthermor macrophag car mice exhibit impair abil phagocytos upec data clear demonstr protect role car experiment chronic pyelonephr macrophag car play major role protect car necessari phagocytosi upec macrophag observ car agonist curtail patholog suggest therapeut potenti activ car chronic infect | D004927;D011704;D011951 | T129;T047;T116;T192 |
36,250,883 | technic trick extract stingray spine hand case report injuri stingray fish among common fish sting frequenc increas increas global tourism common caus injuri extrem caus morbid treat appropri less common life threaten injuri observ due injuri thorax abdomen damag larg vessel vital organ addit sever pain tissu necrosi secondari infect injuri system symptom may occur sinc injuri occur fresh salt water possibl encount case time flat spine sharp backward barb serrat make difficult extract penetr tissu first aid surgic extract stingray spine minim damag essenti addit local system treatment literatur studi envenom system find stingray spine injuri public avail stingray spine extract techniqu injuri case report present new help techniqu stingray spine extract | D012860;D001733 | T037;T013 |
36,250,882 | conserv treatment idiopath frozen shoulder supervis neglect answer systemat review aim studi assess benefici conserv treatment idiopath frozen shoulder | D012785;D002062 | T047;T023;T030 |
36,250,881 | singl stage minim invas plate fixat safe open distal radius fractur metadiaphys involv retrospect evalu patient aim studi evalu safeti result one stage surgeri gustilo grade open distal radius fractur metadiaphys involv | D005597;D011885;D005596 | T037 |
36,250,880 | intraop determin riski angl safe distanc prevent deep femor arteri injuri proxim femor nail hip fractur asian peopl proxim femor nail deep femor arteri injuri rare condit often miss found late lead intract complic fals aneurysm hematoma anemia aim determin novel indic high risk vertic rang axial angl deep femor arteri injuri easili confirm intraop use fluoroscopi hip fractur | D005594;D006620;D057772;D005264 | T061;T037 |
36,250,879 | investig magnet reson imag cross section area best correl intraop hamstr autograft size studi aim find level gracili semitendinosus tendon would provid closest inform size quadrupl strand hamstr autograft use magnet reson imag anterior cruciat ligament reconstruct | D059549;D000070632;D000070598 | T061;T023;T037 |
36,250,878 | youtub provid insuffici inform patellofemor instabl video upload youtub go review process therefor video relat patellofemor instabl may littl educ valu purpos studi assess educ qualiti youtub video regard patellofemor instabl | D061108;D007593;D057071 | T033;T170;T030 |
36,250,877 | analysi risk factor amput patient diabet foot ulcer cohort studi tertiari center studi aim analyz risk factor amput overal minor major patient diabet foot ulcer dfus | D017719;D003920 | T047 |
36,250,870 | impact diabet outcom cardiogen shock systemat review meta analysi provid synthes evid associ diabet clinic outcom patient acut myocardi infarct ami associ cardiogen shock cs analyz observ studi patient ami cs identifi systemat search use pubm scopus databas main outcom mortal outcom interest risk major bleed infarct cerebrovascular advers event need revascular conduct meta analysi data studi compar patient without diabet diabet increas risk hospit mortal ci cerebrovascular complic ci found similar risk major bleed ci infarct ci need vascular ci well hospit stay length day wmd ci n two group patient patient diabet acut mi associ cardiogen shock increas risk mortal advers cerebrovascular event without diabet | D003920;D009203 | T047 |
36,250,850 | associ two bogus item demograph militari characterist cross section survey us armi soldier careless respond survey suffici character militari popul object current studi determin proport characterist careless respond survey given larg sampl us armi soldier instal n two bogus survey item ask assess careless respond near soldier respond correct answer bogus item incorrect answer least bogus question adjust multipl logist regress model race marit status associ incorrect answer bogus item question control covari specif odd black respond incorrect answer bogus item adjust odd ratio aor ci time white respond recommend stem result survey influenc polici decis larg proport careless respons could inadvert lead result repres popul survey careless respond could detect inclus bogus item militari survey would allow research analyz careless respons may impact outcom interest | D008889 | T097 |
36,250,849 | evalu icd cm base case definit ambulatori encount covid among depart defens health care beneficiari sar cov icd cm base case definit lack literatur analysi conduct evalu perform metric covid case definit among depart defens dod beneficiari sar cov test specimen collect march februari match ambulatori medic encount match covid case definit icd cm u high specif posit predict valu ppv low moder sensit covid specif case definit addit code ad moder high specif moder sensit low moder ppv covid like ill case definit addit code ad covid specif definit moder specif moder sensit low moder ppv regardless case definit metric improv surveil period covid case definit ideal studi need ensur case true posit howev broad surveil effort covid specif case definit may best maxim specif without larg decreas sensit ppv | D000086382;D008889 | T047;T097;T067 |
36,250,848 | updat sexual transmit infect activ compon us arm forc report summar incid rate common sexual transmit infect stis among activ compon servic member us arm forc infect chlamydia common follow decreas order frequenc infect genit human papillomavirus hpv gonorrhea genit herp simplex virus hsv syphili compar men women higher rate stis except syphili general compar respect counterpart younger servic member non hispan black servic member singl otherunknown marit status enlist servic member higher incid rate stis although rate chlamydia gonorrhea increas among male femal servic member latter half surveil period notabl decreas rate chlamydia sex rate gonorrhea decreas slight men women rate syphili general increas first half surveil period decreas increas rate genit hsv declin period male femal servic member rate genit hpv decreas steadili men declin among women similar differ find last msmr updat stis discuss | D002690;D006069;D015658;D006558;D008889;D030361;D012749;D013587 | T047;T097 |
36,250,847 | evalu use direct viral transport medium sampl without nucleic acid isol sar cov diagnosi rt pcr diagnosi revers transcriptas polymeras chain reaction rt pcr test import step control covid pandem aim studi compar rt pcr result sampl taken direct viral transport medium vtm without extract rt pcr result two differ extract method one autom manual diagnosi covid | D000086382;D009696 | T123;T047;T067;T114 |
36,250,846 | associ vitamin defici dyslipidemia obes incid coronari arteri diseas type diabet saudi patient diabet mellitus type tdm chronic metabol diseas associ vascular complic aim evalu relationship vitamin defici dyslipidemia obes incid coronari arteri diseas type diabet mellitus | D003324;D003924;D050171;D014808 | T047;T046 |
36,250,845 | clinic efficaci potato extract allevi chemoradiotherapi relat leukopenia random singl blind placebo control trial leukopenia common advers event chemotherapi natur product prevent treat aim studi investig clinic efficaci potato extract allevi chemoradiotherapi induc leukopenia cancer patient | D001688;D007970;D009369;D011198 | T123;T121;T168;T191;T047;T002 |
36,250,844 | c reactiv protein ferritin procalcitonin moroccan patient covid covid true global pandem sinc march respons major patient mild symptom howev small number patient progress sever form acut respiratori distress syndrom ard progress sever form fatal come multiorgan failur thus import identifi earli possibl patient high risk progress sever form requir earli special manag order reduc mortal | D000086382 | T047;T067 |
36,250,843 | red blood cell deform distribut width patient hematolog neoplasm despit increas evid red blood cell rbc deform impair patholog condit littl research done rbc deform hematolog diseas author measur rbc deform patient various hematolog diseas includ hematolog malign | D000741;D006402;D019337;D015464;D015470;D009190;D054198 | T047;T191;T046 |
36,250,842 | saliva diagnost materi current method collect oral caviti recent year attent paid use saliva laboratori diagnost aim monitor human health diseas provid fundament overview take reader composit function protect effect signific role biomark therefor purpos research current review topic saliva composit relat appli secretori stimuli use clinic laboratori | D009055;D012463 | T029;T031;T030 |
36,250,841 | predict valu alter laboratori routin ferritintransferrin ratio monitor covid patient inflammatori process activ rapid viral replic sar cov play key role pathogenesi multipl organ damag respons covid patient dramat outcom common abnorm laboratori find aim studi assess correl various laboratori biomark ferritintransferrin ratio ftr receiv oper characterist roc analysi monitor covid patient | D000086382 | T047;T067 |
36,250,840 | comparison cytokin hemadsorpt immunomodul therapi covid patient without bacteri sepsi retrospect studi aim compar laboratori clinic result cytokin hem adsorpt immunomodul therapi covid icu patient without sepsi | D000086382;D018805 | T047;T046;T067 |
36,250,839 | preval protein variant patient diagnos covid rapid spread new sever acut respiratori syndrom coronavirus sar cov caus coronavirus diseas covid facilit emerg numer variant present studi aim investig preval chang import protein variant ny delh ek sar cov pcr posit patient diagnos covid refer privat hospit within period mutat detect covid pandem | D000086382;D000086402 | T047;T005;T067 |
36,250,838 | cholesterol uptak capac cord blood preterm infant insuffici research cholesterol uptak capac cuc preterm infant therefor relationship cuc cholesterol transport preterm infant unclear studi aim clarifi relationship cuc anthropometr measur high densiti lipoprotein cholesterol hdl c level hdl c subclass preterm infant | D005312;D007234 | T033;T100;T031 |
36,250,837 | impact mdr ugt gene polymorph sodium valproat plasma concentr patient epilepsi studi aim identifi effect multidrug resist gene mdr ugt gene polymorph plasma concentr vpa subject epilepsi provid refer individu medicin patient epilepsi | D004827;D014453;D014635;D020168 | T121;T123;T116;T109;T033;T126;T047 |
36,250,836 | refer rang lymphocyt subset healthi individu southern iran lymphocyt immun phenotyp consid use tool diagnosi monitor differ medic condit studi aim establish refer valu differ lymphocyt subset healthi individu southern iran | D016131;D016176 | T185;T025 |
36,250,835 | epidemiolog surveil blood donor kinshasa systemat detect hiv hepat b hbv c hcv virus blood donor effect univers hospit kinshasa sinc howev data monitor blood donor avail today purpos thesi draw sero epidemiolog assess afor mention virus period | D015658;D006509;D006526;D013587 | T047 |
36,250,834 | taqman mgb fq pcr human gpiiia gpba pear snps reliabl oper conveni taqman mgb probe fluoresc quantiti polymeras chain reaction fq pcr detect human gpiiia gpba pear polymorph design perform assess | D039661;D020641 | T123;T116;T086 |
36,250,833 | correl among circul tumor cell epstein barr virus status epidemiolog patient nasopharyng carcinoma studi shown circul tumor cell ctcs detect nasopharyng carcinoma npc howev relationship ctcs tumor stage still controversi studi aim investig correl among ctcs epstein barr virus ebv status clinicopatholog featur epidemiolog risk factor patient npc | D020031;D009303;D009360 | T047;T191;T025 |
36,250,832 | seropreval anti thyroglobulin antibodi korea appropri use thyroglobulin tg test involv concurr measur tg auto antibodi tg ab due potenti fals low fals high tg due tg ab interfer | D001323;D013964 | T129;T191;T116 |
36,250,831 | import neutrophil gelatinas associ lipocalin liver type fatti acid bind protein acut kidney injuri import factor diagnosi aki accur earli detect damag occur kidney filtrat capac kidney decreas therefor discuss use ngal l fabp earli diagnosi acut kidney injuri evalu clinic sever prognosi well predict hemodialysi decis prospect studi | D058186;D054834 | T123;T047;T116;T037 |
36,250,830 | establish non invas grade model primari iga nephropathi base multi center popul necessari adopt special therapeut schedul treat iga nephropathi igan distinct patholog stage would help treatment know patholog chang throughout igan cours therefor want establish non invas method determin patholog grade igan | D005922 | T047 |
36,250,829 | rapid bacteri identif drug sensit test method pathogen posit blood cultur turnov time posit blood cultur use tradit method take long studi aim evalu rapid direct identif drug sensit test method pathogen posit blood cultur | D016470;D006094 | T047;T007 |
36,250,828 | aberr phenotyp acut myeloid leukemia hematolog laboratori experi univers hospit casablanca morocco aberr phenotyp acut myeloid leukemia variabl frequenc prognost valu advers hematolog biolog prognost factor still controversi despit sever report clinic signific date studi report evalu incid phenotyp aberr moroccan popul aim evalu incid aberr phenotyp express acut myeloid leukemia correl presenc differ aml subtyp clinic biolog characterist moroccan patient | D006405;D015470 | T191;T091 |
36,250,827 | regul circul mir p mir p mir let c women idiopath recurr pregnanc loss recent circul microrna attract much attent serv reliabl non invas diagnost biomark human diseas studi aim quantifi mir p mir p mir let c express level plasma sampl patient idiopath recurr pregnanc loss irpl healthi subject evalu potenti diagnost valu diagnosi irpl | D000026;D035683;D000074166 | T123;T047;T114 |
36,250,826 | evalu mx gene promot methyl differ sever covid consid patient gender coronavirus diseas covid caus sever acut respiratori syndrom coronavirus sar cov led pandem march viral infect report epigenet chang occur side infect cell elicit antivir environment respons induc initi certain pathway proper respons virus virus silenc express vital gene anti viral host cell studi aim examin methyl level mx gene promot differ stage covid patient compar control group | D000086382;D064547;D019175 | T121;T116;T067;T047;T044 |
36,250,825 | evalu len culinari agglutinin reactiv fetoprotein diagnosi malign tumor assess potenti afp l util diagnos malign tumor | D006528;D008113 | T191 |
36,250,824 | pattern possibl fals posit result three commerci real time pcr kit sar cov retrospect examin initi posit sar cov test result use three real time pcr test patient without histori covid collect septemb octob univers affili hospit | D000086382;D000086402 | T047;T005;T067 |
36,250,823 | predict model base blood indic admiss icu aecopd aecopd common caus death among infecti diseas develop countri also import caus mortal morbid develop countri recent year relat score system mmrc score cat questionnair wide use assess sever aecopd howev shortcom predict admiss aecopd patient icu studi aim develop new predict model predict admiss aecopd patient icu base object blood indic | D000077740;D029424 | T123;T047;T116 |
36,250,822 | evalu relationship exhal co level clinic cours parenchym involv covid covid caus sar cov virus infect near million peopl past two year aim determin exhal co level patient hospit covid pneumonia correl parenchym involv | D000086382;D012141 | T047;T067 |
36,250,821 | molecular studi accessori gene regul staphylococcus aureus isol sepsi pediatr patient pediatr sepsi due staphylococcus aureus aureus associ high morbid mortal accessori gene regul agr role pathogenesi aureus control regul express virul gene therefor aim present studi investig preval genotyp agr system aureus isol children sepsi assess relationship biofilm format antibiot resist | D055624;D018805;D013203 | T047;T007;T046 |
36,250,820 | establish sar cov immunoglobulin igm igg refer interv elder popul china base sampl establish refer interv ris differ biomark essenti clinic monitor purpos studi establish laboratori ris sar cov igm igg elder popul | D000086382;D000086402 | T047;T005;T067 |
36,250,819 | associ serum erythrocyt immun function index blue light treatment sever pjon associ serum erythrocyt immun function index blue light treatment effect sever child patient patholog jaundic testifi | D000936;D007565 | T129;T047;T116;T184 |
36,250,818 | plasma exosom cxcl potenti biomark lung adenocarcinoma lung cancer lead caus cancer relat death lung adenocarcinoma luad repres common subtyp recent exosom base biomark provid new diagnost approach malign | D000077192;D055354;D008175 | T026;T191 |
36,250,815 | absolut relat morbid burden attribut various ill injuri non servic member beneficiari militari health system mental health disord account largest proport morbid health care burden affect pediatr younger adult beneficiari age group among adult age age older musculoskelet diseas account morbid health care burden previous year report document substanti major non servic member beneficiari receiv care current ill injuri militari health system outsourc servic non militari medic facil | D001523;D000081322;D008889;D009140 | T047;T058;T097;T048 |
36,250,787 | rate role pseudogen mycobacterium tuberculosi complex whole genom sequenc analys signific contribut understand virul evolut mycobacterium tuberculosi complex mtbc causat pathogen tuberculosi mtbc evolutionari studi focus singl nucleotid polymorph delet rare studi evalu gene content wherea none comprehens evalu pseudogen accord describ extens studi focus quantifi predict possibl function mtbc mycobacterium canettii pseudogen use ncbi pgap detect pseudogen analys pseudogen mtbc canetii strain combin transcriptom proteom tuberculosi hrv gain insight pseudogen express result indic signific variabl concern rate conserv silico predict pseudogen among differ ecotyp lineag tubercul mycobacteria pseudogen import virul factor gene metabol antimicrobi resistancetoler show silico predict pseudogen contribut consider mtbc genet divers popul level moreov transcript machineri tuberculosi fulli transcrib pseudogen indic intact promot recent pseudogen evolutionari emerg proteom tuberculosi close evalu mutat lesion drive pseudogen suggest silico predict pseudogen like capabl neofunction nonsens mutat revers phase variat contradict classic definit pseudogen find indic genom annot accompani proteom protein function assay improv accuraci indel insert sequenc main driver observ mutat lesion speci popul bottleneck genet drift like evolutionari process act pseudogen emerg time find unveil new perspect mtbc evolut genet divers | D009169;D011544 | T007;T028 |
36,250,783 | morbid burden attribut various ill injuri deploy activ reserv compon servic member us arm forc previous year among servic member deploy injurypoison musculoskelet diseas signssymptom account half total health care burden deploy compar garrison diseas burden deploy servic member relat higher proport encount respiratori infect skin diseas infecti parasit diseas recent mark increas percentag total medic encount attribut icd diagnost categori like due increas diagnost test immun associ respons covid pandem | D000086382;D008889;D009140 | T047;T097;T067 |
36,250,782 | medic evacu us central us africa command activ reserv compon us arm forc proport evacu uscentcom due battl injuri declin substanti uscentcom evacu mental health disord common follow non battl injuri poison sign symptom ill defin condit usafricom evacu non battl injuri poison common follow disord digest system mental health disord | D008889;D014187 | T058;T097 |
36,250,781 | antihistamin motion sick motion sick syndrom occur result passiv bodi movement respons actual motion illus motion expos virtual move visual environ common symptom nausea vomit antihistamin use manag motion sick decad howev studi shown conflict result regard efficaci | D000932;D002936;D004111;D009041 | T047;T121;T039;T109 |
36,250,774 | three dimension vessel chip base hipsc deriv vascular endotheli smooth muscl cell blood vessel compos endotheli cell ec form inner vessel wall mural cell cover ec mediat stabil crosstalk ec vsmcs ec undergo microfluid flow vital function integr blood vessel describ protocol generat three dimension engin vessel chip voc compos vascular cell deriv human induc pluripot stem cell hipsc first describ protocol robust differenti vascular smooth muscl cell hipsc vsmcs hipsc effect across multipl hipsc line second describ fabric simpl microfluid devic consist singl collagen lumen act cell scaffold support fluid flow use viscous finger pattern vfp techniqu channel seed sequenti hipsc deriv ec hipsc ec hipsc vsmcs stabl ec barrier cover vsmcs line collagen lumen demonstr voc model recapitul physiolog cell cell interact perfus physiolog shear stress use microfluid pump uniform geometri vessel lumen allow precis control flow dynam thus develop robust protocol generat entir isogen hipsc deriv voc model could valuabl studi vessel barrier function physiolog healthi diseas state author current protocol publish wiley period llc basic protocol differenti hipsc vsmcs support protocol character hipsc nccs hipsc vsmcs support protocol prepar cryopreserv hipsc vsmcs hipsc ec voc cultur basic protocol generat voc model compos hipsc ec hipsc vsmcs support protocol structur character voc model | D057026;D055549 | T025;T109 |
36,250,769 | lichen simplex chronicus itch updat lichen simplex chronicus form chronic local pruritus secondari dermat one common type chronic itch condit estim affect general popul howev despit preval burden limit research pathogenesi aetiolog lichen simplex chronicus histor made challeng condit treat recent year understand condit along pruritus itch scratch cycl increas great enabl substanti increas treatment option addit sever new promis treatment current develop trial articl discuss definit epidemiolog clinic characterist pathophysiolog current therapeut option lichen simplex chronicus order highlight recent advanc field | D009450 | T047 |
36,250,758 | structur reactiv relationship buchwald type phosphin nickel catalyz cross coupl dialkyl ortho biaryl class phosphin common known buchwald type ligand among import phosphin pd catalyz cross coupl ligand also success appli sever synthet valuabl ni catalyz cross coupl methodolog demonstr work top perform ligand ni catalyz suzuki miyaura coupl smc c n coupl reaction even outperform common employ bisphosphin like dppf mani circumst howev littl known structur reactiv relationship srrs ni limit exampl well defin catalyt relev ni complex buchwald type ligand exist work report analysi buchwald type phosphin srrs four repres ni catalyz cross coupl reaction studi guid data driven classif analysi togeth mechanist organometal studi structur character ni ni ni ii complex allow us ration reactiv pattern catalysi overal expect studi serv platform explor ligand class organonickel chemistri well develop new ni catalyz cross coupl methodolog | D010720 | T104 |
36,250,757 | ambulatori visit activ compon us arm forc overal number rate activ compon servic member ambulatori care visit highest last year categori ill injuri show modest increas number rate proport ambulatori care visit accomplish via telehealth encount fell compar although respons covid pandem may associ decreas incid diseas injuri diagnos servic member popul receiv ambulatori care data show return pre pandem level moreov proport health care encount deliv telehealth similar revert lower level seen pre pandem period lesson learn may guid futur step reduc diseas injuri incid postpandem era | D000086382;D008889;D017216 | T047;T058;T097;T067 |
36,250,756 | hospit activ compon us arm forc hospit rate per person year p yrs second lowest rate recent year hospit limit militari facil rate lowest entir period prior year major hospit associ diagnos categori mental health disord pregnanc relat condit injurypoison digest system disord | D001523;D008889 | T097;T048 |
36,250,745 | mechanist insight charg transfer dynam photocatalyt water oxid lipid bilay water interfac photosystem ii natur water oxid system larg protein complex embed phospholipid membran much simpler system photocatalyt water oxid consist liposom function amphiphil ruthenium ii tris bipyridin photosensit ps dicarboxylato bipyridin ruthenium ii catalyst cat water solubl sacrifici electron acceptor na howev effect embed photocatalyt system liposom membran mechan photocatalyt water oxid well understood sever phenomena identifi spectroscop tool explain drastic differ kinet water photo oxid liposom compar analog homogen system first oxid quench photoexcit ps liposom surfac occur sole via static quench dynam quench observ homogen system moreov charg separ effici quench reaction much smaller uniti contrast quantit generat ps homogen solut parallel high local concentr membran bound ps induc self quench molar lipid ps ratio final hole transfer ps catalyst rather fast homogen solut k ob catalyst liposom ph reaction rather slow k ob catalyst dmpc lipid overal better understand product unproduct pathway explain limit rate photocatalyt water oxid liposom vs homogen system requir futur optim light driven catalysi within self assembl lipid interfac | D014867;D012428 | T121;T197;T196 |
36,250,744 | gestat malnutrit hyperemesi gravidarum wernick encephalopathi miss hyperemesi gravidarum hg sever nausea vomit pregnanc one dread complic gestat affect pregnant women late mid etiolog frequent cite psycholog andor later perhap hormon origin number least current research unearth genet basi hg implic growth differenti factor insulin like growth factor bind protein hormon receptor name glial cell line deriv neurogen factor famili receptor alpha like progesteron receptor whatev origin diseas caus immeasur physiolog psycholog damag women fetus famili psycholog trauma includ high rate suicid ideat well posttraumat stress disord wherea healthcar cost substanti mother hg lifetim cost neonat includ accompani reduc employ earn relat cognit compromis anoth devast outcom sever hg wernick encephalopathi high fetal matern mortal rate studi explor current report hg highlight addit present featur believ also accompani sometim replac classic taught triad compon ataxia confabul nystagmus agre conclus made sheehan ironsid thiamin alon may revers offer possibl explan last offer suggest remedi | D014899;D006939 | T184;T047 |
36,250,738 | soft wearabl microfluid patch finger actuat pump valv demand longitudin multianalyt sweat sens easi sampl collect physiolog relev abil noninvas longitudin monitor human bodi key attribut wearabl sweat sensor exampl typic includ revers sensor array singl use sensor embed special microfluid tempor analysi sweat howev evolv field level truli repres lab skin technolog requir incorpor advanc function give user freedom choos precis time perform sampl analysi select sensor array embed within devic perform condit specif sampl analysi introduc new concept wearabl microfluid platform offer capabl describ technolog involv seri finger actuat pump valv sensor incorpor within soft wearabl microfluid incom sweat collect inlet chamber analyz user time choos demand sweat analyt assess achiev pull thin tab activ pump open valv allow pool sweat enter chamber embed sensor desir analyt articl describ thorough character platform demonstr robust pump valv sens aspect devic condit mimick real life scenario two day long human pilot studi valid system illustr devic abil offer demand longitudin multianalyt sens work repres first exampl wearabl system demand sens capabl open excit avenu sweat sens acquir new insight human physiolog | D013542;D000076251 | T073;T031 |
36,250,737 | absolut relat morbid burden attribut various ill injuri activ compon us arm forc prior year medic condit associ medic encount largest number affect servic member greatest number hospit day major categori injuri musculoskelet disord mental health disord despit pandem covid account less total medic encount bed day activ compon servic member injuri musculoskelet disord mental health disord detract servic member individu readi deploy hinder abil execut mission arm forc continu focus enhanc measur prevent treat disord warrant | D000086382;D001523;D008889;D009140 | T047;T097;T067;T048 |
36,250,731 | risk skin cancer actin keratosi patient rosacea nationwid popul base cohort studi associ rosacea skin cancer remain inconclus conflict report aim nationwid popul base cohort studi determin risk skin cancer patient rosacea rosacea cohort n formul evalu incid rate ratio actin keratosi cutan melanoma keratinocyt carcinoma gastric colorect liver cancer analys comparison match control group multivari stratifi cox proport hazard model analysi perform risk actin keratosi keratinocyt carcinoma increas rosacea group compar control group adjust hazard ratio confid interv respect risk cutan melanoma gastric colorect liver cancer increas adjust hazard ratio respect result reveal increas risk actin keratosi keratinocyt carcinoma patient rosacea | D055623;D012878;D008545;D012393;D002277;D015179 | T047;T191 |
36,250,721 | emerg kinas inhibitor treatment pancreat ductal adenocarcinoma pancreat cancer one deadliest solid organ cancer absenc specif warn symptom pancreat cancer diagnos notori late current system chemotherapi regimen extend surviv mere month advanc genet proteom immunolog profil strong rational test kinas inhibitor improv outcom | D021441;D010190 | T191 |
36,250,718 | aberr express microrna mir human diseas mirna small endogen rna import regul gene express mir abnorm express diseas includ cancer express mir regul upstream factor mir downstream target gene mir inhibit express target gene therebi affect migrat prolifer invas patholog cell mir particip signal pathway play role occurr develop sever diseas addit mir also promot resist multipl drug articl summar aberr express mir pathogen molecular mechan human diseas provid clue direct follow research mir | D035683;D004194 | T123;T047;T114 |
36,250,716 | wast deriv volatil fatti acid product ammonium remov ion exchang process natur zeolit volatil fatti acid vfas produc anaerob digest ad organ wast promis altern carbon sourc various biolog process howev applic limit due presenc impur ammonium nh studi investig potenti remov ammonium use natur occur zeolit clinoptilolit chicken manur ckm deriv vfa effluent recov anaerob membran bioreactor mbr experi conduct synthet actual vfa ad vfa solut effect differ paramet investig batch continu studi observ langmuir type isotherm provid best fit equilibrium data isotherm investig carri ad vfa solut maximum adsorpt capac q found mg nh g clinoptilolit effect oper paramet process perform ph initi nh load potassium ion k concentr investig ph neglig effect ammonium remov ph rang remov effici ammonium decreas increas initi nh load k concentr optimum condit determin batch experi ammonium remov synthet ad vfa solut compar averag ammonium remov effici found h equilibrium time synthet ad vfa solut respect overal find indic clinoptilolit excel potenti ion exchang combin biolog process acidogen ferment vfas purifi solut high ammonium content | D064751;D017641 | T104;T197 |
36,250,708 | cart restor transient respons ifn type hiv infect human mice lack human immunodefici virus hiv cure heighten interest immunotherapi type interferon ifn particular ifn alpha ifn gain renew attent howev hiv pathogenesi driven sustain ifn mediat immun activ use ifn rather controversi follow question therein remain ifn subtyp use ii regimen iii time point hiv infect might benefici use ifn modifi pasyl long half life vivo eventu treat hiv infect defin ifn dose regimen base maximum increas interferon stimul gene isg express h administr return baselin ubiquitin specif proteas usp prior next dose notabl usp major negat regul type ifn signal hiv infect result increas isg express level human mice intrigu high baselin isg level correl lower hiv load effect observ hiv replic pasyl ifn administ chronic phase howev combin antiretrovir therapi cart restor respons ifn pasyl ifn administ analyt cart interrupt result transient lower hiv burden mock treat mice conclus cart mediat hiv suppress restor transient ifn respons provid potenti window immunoenhanc therapi context analyt cart interrupt import cart high effici suppress hiv replic hiv infect patient result dramat reduct morbid mortal hiv infect peopl yet cure hiv infect addit cart sever disadvantag thus hiv research communiti explor novel way control hiv infect longer period without cart explor novel long act ifn efficaci control hiv replic hiv infect human mice found ifn effect chronic hiv infect howev mice treat first cart observ transient restor respons inf transient lower hiv burden stop cart data emphas valu cart mediat hiv suppress immun reconstitut creat window opportun explor novel immunotherapi ii potenti ifn constrain hiv iii valu human mice explor novel immunotherapi | D015658;D007370 | T129;T047;T121;T116 |
36,250,705 | prepar denitrif phenotyp diversif cusp anoxia purpos n reductas vis vis multipl role adapt anoxia synthes denitrif proteom cost metabol energi anaerob respir conserv less energi per electron aerob respir impli select advantag stringent repress denitrif gene transcript found denitrifi bacteria bacteria metabol burden adapt minim phenotyp diversif colloqui term bet hedg cell synthes n reductas nosz minor synthes nitrit reductas nir demonstr model strain paracoccus denitrifican hypothes cell lack nir would entrap anoxia possibl escap suppli n test cell expos gradual deplet sudden anoxia subsequ spike n synthesi nir singl cell monitor use mcherri nir fusion replac nativ nir growth detect dilut green fluoresc fluorescein isothiocyan fitc stain demonstr anox entrap due e acceptor depriv show spike lead bet hedg n spike promot nir synthesi growth cell carri nosz cell rescu n spike much lower respir rate rescu spike howev could indic well known autocatalyt synthesi nir via product requir result bring relief fit advantag pair restrict nir express univers nosz synthesi energi limit system import denitrifi bacteria evolv elabor regulatori network secur respiratori metabol environ fluctuat oxygen concentr provid new insight regard bet hedg respons hypoxia minim n emiss cell express nosz reduc n n minor express nir reduc n hypothes cell without nir entrap anoxia without energi synthes nir could rescu short spike n confirm entrap rescu cell n spike fraction spike result shed light role repress bet hedg generat novel hypothesi regard autocatalyt nir express via product insight regul denitrif includ bet hedg hold clue understand ultim curb escal emiss n contribut anthropogen climat forc | D010088;D010231 | T007;T126;T116 |
36,250,704 | strong isotop fraction oxygen tio obtain surfac enhanc solid state diffus isotop pure semiconductor import applic cool electron devic quantum comput sens raw materi suffici high isotop puriti expens difficult obtain therefor post synthesi method remov isotop impur would valuabl isotop self diffus measur oxygen rutil tio singl crystal immers water demonstr fraction factor natur abund near surfac region nm wide submerg surfac inject interstiti displac lattic deeper solid result statist interstitialci mediat diffus combin steep chemic gradient interstiti slight acid slight basic liquid solut enhanc fraction affect detail isotop profil shape sever chemic physic mechan | D010100;D003205 | T123;T121;T196;T170;T057 |
36,250,702 | auto hetero catalyt process n termin propeptid promot c termin fibronectin type iii domain mediat dimer thermost vpr like proteas microbi vpr like proteas extracellular multidomain subtilas divers function form oligom matur oligomer mechan remain elucid report novel vpr like proteas btv thermophil bacterium brevibacillus sp wf btv precursor compris signal peptid n termin propeptid subtilisin like catalyt domain insert proteas associ pa domain two tandem fibronectin type iii domain fn fn c termin propeptid btv proform pro btv could autoprocess matur form mbtv via two intermedi lack n c termin propeptid respect c termin propeptid delay autocatalyt matur enzym comparison pro btv effici process mbtv proteas tss strain wf purifi mbtv ca depend thermost proteas show optim activ c retain activ incub c h pa domain import enzym stabil contribut substrat specif btv restrict access protein substrat activ site proform matur form btv exist monom homodim respect dimer mediat fn fn domain n termin propeptid btv act intramolecular chaperon enzymat inhibitor also inhibit homodimer enzym remov n termin propeptid lead structur adjust enzym thus promot enzym dimer import vpr like proteas wide distribut bacteria fungi involv process lantibiot degrad collagen keratin fibrin pathogenesi microb dissect role individu domain enzym matur oligomer crucial understand action mechan multidomain proteas result demonstr hetero catalyt matur extracellular vpr like proteas btv brevibacillus sp wf effici autocatalyt matur enzym moreov found c termin tandem fibronectin type iii domain rather pa domain mediat dimer matur btv n termin propeptid inhibit dimer btv proform studi provid new insight activ oligomer mechan vpr like proteas | D010447;D000071238 | T121;T087;T126;T116 |
36,250,698 | evalu characterist infect secondari inoculum produc plasmopara viticola grapevin leav mean flow cytometri fluoresc activ cell sort plasmopara viticola oomycet caus grapevin downi mildew one import pathogen viticultur p viticola polycycl pathogen abl carri numer secondari cycl infect singl veget grapevin season produc asexu spore zoospor within sporangia extent infect strong influenc quantiti densiti qualiti infect inoculum produc pathogen date protocol evalu characterist quit limit time consum allow inform obtain singl run studi protocol combin flow cytometri fcm fluoresc activ cell sort fac develop investig composit infect effici dynam inoculum produc p viticola secondari infect cycl analys identifi differ structur within inoculum includ degener intact sporangia latter sort singl sporangia direct inocul grapevin leaf disc thus allow thorough investig infect dynam effici detail determin condit sporangia abl infect leav suscept varieti time requir pathogen reach total infect day analyt approach develop studi could open new perspect shed light biolog epidemiolog import pathogen import p viticola secondari infect contribut signific epidemiolog import plant pathogen howev infect dynam asexu spore produc organ still poor investig main challeng dissect grapevin p viticola interact vitro attribut biotroph adapt pathogen work provid new insight infect effici dynam imput p viticola sporangia contribut use inform grapevin downi mildew epidemiolog moreov futur applic sort protocol develop work could yield signific posit impact studi p viticola provid unmatch resolut precis accuraci compar tradit techniqu | D027843;D009868 | T129;T116;T168;T204;T002 |
36,250,697 | analyz impact multimorbid long term outcom emerg general surgeri retrospect observ cohort studi littl known impact multimorbid long term outcom older emerg general surgeri patient | D006278;D000076322 | T089;T078;T064 |
36,250,688 | novel pyrazol carboxamid contain diarylamin scaffold potenti target fungal succin dehydrogenas antifung activ mechan action succin dehydrogenas sdh known ideal target develop novel fungicid year seri novel pyrazol carboxamid contain diarylamin scaffold report potent sdh inhibitor sdhis laboratori among compound scu ec mgl vitro rhizoctonia solani better fluxapyroxad ec mgl howev mechan action still unclear paper pot test bioactiv evalu indic vivo antifung activ compound scu ec mgl r solani better fluxapyroxad ec mgl thifluzamid ec mgl field trial control efficaci compound scu g aiha rice sheath blight better thifluzamid furthermor target evalu show compound scu could inhibit fungal sdh r solani fix bind site sdh molecular dock therebi could dissolv reduc mitochondria r solani observ electron microscopi addit transcriptom result show compound scu affect tca cycl pathway mitochondria manifest downregul eight gene upregul one gene import phenomenon repress express sdh confirm qrt pcr observ compound scu potent sdhi result afford research pyrazol carboxamid | D013385;D005659 | T131;T126;T116 |
36,250,687 | chang morpholog dimyristoylphosphatidylcholinebil salt deriv bicell assembl dodecylmaltosid disk ribbon phase bicell compos mixtur long short chain lipid form nanostructur molecular assembl attract lipid membran mimic vitro studi integr membran protein studi effect third compon singl chain deterg n dodecyl maltosid ddm morpholog bicell compos dimyristoyl sn glycero phosphocholin dmpc cholamidopropyl dimethylammonio hydroxi propanesulfon chapso c c phase transit absenc ddm bicell convert ellipsoid disk c extend ribbon like structur c addit ddm reshap ellipsoid disc circular one flatten ribbon circular cylind worm like micell knowledg influenc singl chain deterg ddm bicell nanoscal morpholog contribut toward comprehend lipid membran self organ goal optim lipid mimic membran biolog research | D004134;D008823 | T121;T130;T109 |
36,250,685 | rest state eeg function connect predict post traumat stress disord subtyp veteran object post traumat stress disord ptsd high heterogen identif quantifi biomark could pave way target treatment remain challeng previous electroencephalographi eeg studi ptsd limit specif handpick featur find high variabl inconsist therefor disentangl role promis eeg biomark develop machin learn framework investig wide rang common use eeg biomark order identifi featur combin featur capabl character ptsd potenti subtyp approach record min eye close min eye open rest state eeg combat expos veteran probabl ptsd combat expos control multipl spectral tempor connect featur comput logist regress random forest support vector machin featur select method employ classifi ptsd obtain robust result perform repeat two layer cross valid test entir unseen test set main result classifi obtain balanc test accuraci predict ptsd patient addit identifi two subtyp within ptsd one eeg pattern similar combat expos control anoth character increas global function connect classifi obtain balanc test accuraci classifi ptsd subtyp control clear improv compar predict whole ptsd group interest alpha connect dorsal ventral attent network particular import predict connect posit correl arous symptom score central symptom cluster ptsd signific taken togeth novel framework present demonstr unsupervis subtyp delin heterogen improv machin learn predict ptsd may pave way better identif quantifi biomark | D014728;D013313 | T098;T048 |
36,250,680 | target aggrecanas osteoarthr therapi zinc chelat exosit inhibit osteoarthr oa common degen joint diseas two member disintegrin metalloproteinas thrombospondin motif adamt famili metalloproteinas adamt adamt aggrecanas identifi enzym respons aggrecan degrad cartilag first aggrecanas inhibitor target activ site chelat catalyt zinc ion due general disappoint perform zinc chelat inhibitor preclin clinic studi inhibit strategi tri move away activ site zinc order improv select exosit inhibitor bind proteoglycan bind residu present aggrecanas ancillari domain call exosit exosit inhibitor general select zinc chelat inhibitor still far fulfil potenti part due lack structur function data aggrecanas exosit fill gap inform design novel potent select aggrecanas inhibitor | D011348;D010003 | T047;T126;T116 |
36,250,676 | tumor cell deriv exosom lncrna loc inhibit tumorigenesi esophag carcinoma suppress macrophag polar esophag carcinoma ec high malign type tumor previous studi author found long non code rna lncrna loc inhibit tumorigenesi ec moreov exosom deriv tumor cell contain lncrnas found play key role tumor environ howev whether exosom affect tumor microenviron carri loc remain unclear thus present studi aim clarifi order assess effect exosom loc ec cell invas migrat examin use transwel assay exosom identifi use transmiss electron microscopi western blot analysi nanoparticl track analysi furthermor macrophag surfac maker cd cd analyz use flow cytometri moreov subcutan xenograft mous model construct assess role te cell deriv exosom loc ec result reveal loc overexpress notabl suppress metastasi ec cell addit exosom success isol ec cell loc level upregul exosom deriv loc overexpress ec cell exosom loc also suppress macrophag polar polar macrophag decreas ec cell invas exosom contain loc notabl inhibit growth ec mice whole present studi demonstr deliveri loc ec cell secret exosom inhibit tumorigenesi ec suppress polar macrophag find may provid new theoret basi discov new strategi ec | D002277;D035683;D062085 | T123;T191;T114 |
36,250,671 | find novel barbershop base peripher arteri diseas screen program black men background peripher arteri diseas pad increas risk cardiovascular event limb event includ amput pad twice preval black compar non hispan white individu especi among men screen pad use ankl brachial index communiti set barbershop could lead earlier diagnosi treatment method result pilot studi conduct barbershop cleveland oh june decemb assess feasibl screen pad barbershop set effect educ intervent pad awar screen autom doppler ankl brachial index pad identifi particip baselin systol blood pressur low densiti lipoprotein cholesterol random blood glucos higher particip screen posit pad p pad awar low overal signific improv pad awar assess score obtain initi exit visit p associ found pad awar baselin highest educ level achiev compar collegeassoci degre higher non high school graduat score lower pad awar p high school diploma test general educ develop p conclus pilot studi barbershop base screen pad among black men reveal higher expect pad preval low pad awar educ video effect increas pad awar ankl brachial index screen educ outreach barbershop may feasibl effect tool diagnos pad reduc pad dispar among black men highest risk | D001786;D058729 | T047;T109 |
36,250,670 | tachyarrhythmia hospit covid multisystem inflammatori syndrom children adolesc background cardiac complic relat covid children adolesc includ ventricular dysfunct myocard coronari arteri aneurysm bradyarrhythmia tachyarrhythmia less understood goal studi evalu frequenc characterist outcom children adolesc experienc tachyarrhythmia hospit acut sever covid multisystem inflammatori syndrom children method result studi involv case seri patient tachyarrhythmia report public health surveil registri patient age type report registri patient versus without tachyarrhythmia older median age rang versus rang year higher ill sever hospit admiss intervent treatment tachyarrhythmia requir patient includ antiarrhythm medic n electr cardiovers n cardiopulmonari resuscit n extracorpor membran oxygen n patient tachyarrhythmia longer hospit length stay versus die conclus tachyarrhythmia rare complic acut sever covid multisystem inflammatori syndrom children adolesc associ wors clinic outcom highlight import close monitor aggress treatment postdischarg care | D000086382;D013617 | T047;T067 |
36,250,668 | mitral valv surgeri persist recurr mitral regurgit transcathet edg edg repair associ improv surviv background manag sever mitral regurgit mr transcathet edg edg repair teer remain clinic conundrum consid grow volum teer outcom data mitral surgeri cohort need method result symptomat patient persist recurr sever mr teer evalu may june includ primari outcom caus mortal patient treat surgeri versus medic therapi kaplan meier cox regress method use report risk adjust surviv analys among includ patient underw mitral surgeri patient underw surgeri younger treat medic versus year p major comorbid similar except obes sleep apnea left ventricular dimens eject fraction societi thorac surgeon predict risk oper mortal versus surgic versus medic therapi group respect p time teer detect sever mr similar group median interquartil rang versus day surgic versus medic group respect p surgic group valv replac perform patient oper mortal observedexpect ratio major complic uncommon risk adjust surgeri associ signific lower caus mortal adjust hazard ratio ci p compar medial therapi conclus compar medic therapi mitral surgeri patient sever persist recurr mr teer associ lower mortal despit high risk profil patient patient sever mr teer consid surgeri referr mitral surgic center | D008944;D006348;D019918 | T061;T047 |
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