PMID
int64 35.7M
36.4M
| Title/Abstract
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36,316,652
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joint reconstruct neuron ultrastructur via connect consensus electron microscop volum nanoscal connectom aim map fine connect neuron synapt level detail attract increas attent recent year current autom reconstruct algorithm electron microscop volum great demand exist reconstruct methodolog cellular subcellular structur independ explor inter relationship structur contribut imag analysi primari goal research construct joint optim framework improv accuraci effici neural structur reconstruct algorithm
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D004583;D007091
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T081;T196;T066
|
36,316,651
|
efficaci monocarbonyl curcumin analog c reduct diabet associ cardiovascular kidney complic curcumin polyphenol compound deriv turmer potenti benefici properti cardiovascular renal diseas relat safe inexpens howev applic curcumin rather problemat due chemic instabl low bioavail experiment result show improv chemic stabil potent pharmacokinet one analog ee bis trifluoromethyl benzyliden cyclohexanon c sever advantag c like synthet access structur simplic improv chemic stabil vitro vivo presenc two reactiv electrophil center good electron accept capac consid characterist review literatur applic c resolv diabet associ cardiovascular renal complic anim model also summar mechan c prevent releas pro oxid pro inflammatori molecul prime activ stage cardiomyopathi renal fibrosi diabet nephropathi cardiovascular protect effect c diabet induc oxid damag nrf mediat main depend jnk general c caus inhibit jnk reduc cardiac inflamm fibrosi oxid stress apoptosi set diabet cardiomyopathi c exert power antifibrot effect reduc inflamm relat factor mcp nf b tnf il cox cav induc express anti inflammatori factor ho nedd well target tgf smad mapkerk ppar pathway anim model diabet nephropathi base avail evid c becom promis drug candid improv cardiovascular renal health
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D003474;D003928;D003921
|
T121;T050;T109;T047;T130
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36,316,650
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new cycl old mistak overlap vs discret generat long term recurr select recurr select foundat breed method quantit trait improv typic featur rapid breed cycl lead high rate genet gain usual generat discret recurr select mean breed candid evalu consid select one cycl altern generat overlap breed candid consid select parent multipl cycl recurr genom select phenotyp select candid evalu use genom estim breed valu without addit phenotyp candid therefor may candid true high breed valu discard one cycl due underestim breed valu could identifi select subsequ cycl consequ allow generat overlap recurr select unknown assess whether maintain overlap discret generat led differ genet gain phenotyp genom truncat genom optimum contribut recurr select stochast simul
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D012641;D001947
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T045;T040;T070
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36,316,649
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person target therapi prescript colorect cancer use algorithm analysi rna sequenc data overal surviv advanc colorect cancer crc patient remain poor gene express analysi could potenti complement detect clinic relev mutat person crc treatment
|
D015179;D012313
|
T191;T114
|
36,316,648
|
predictor respons anti cgrp monoclon antibodi week multicent prospect studi migrain patient identif predictor respons anticgrp mab could favor tailor therapi person treatment plan studi aim investig predictor respons week patient high frequenc episod hfem daysmonth chronic migrain cm
|
D006930;D008881
|
T184;T047
|
36,316,647
|
effect schistosoma haematobium infect cognit function preschool age children benefit treatment endem area zimbabw schistosomiasi known affect cognit function children howev pauciti inform impact earli childhood develop develop countri diseas endem studi aim determin effect schistosomiasi due schistosoma haematobium earli childhood develop children year old murewa district zimbabw includ benefit treatment
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D012553
|
T047
|
36,316,646
|
sketch sampl approach fast accur long read classif modern sequenc experi quick accur identifi sourc read crucial need metagenom read come one potenti mani member communiti import identifi exact speci read set import distinguish read target sampl potenti contamin case identif correct sourc read enabl investig relev read minim wast work task particular challeng long read substanti error rate obscur origin read
|
D059014;D012984
|
T063;T090;T073;T059;T170
|
36,316,645
|
gamma glutamyl transpeptidas platelet gamma glutamyl transpeptidas lymphocyt ratio sampl chines han popul gamma glutamyl transpeptidas platelet ratio gpr gamma glutamyl transpeptidas lymphocyt ratio glr assum prognost factor liver fibrosi cirrhosi hepatocellular carcinoma howev refer valu gpr glr known
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D005723;D008113
|
T191;T126;T116
|
36,316,644
|
sex differ exist adult heart group innat lymphoid cell group innat lymphoid cell ilc domin ilc heart tissu sex relat differ exist mous lung ilc phenotyp function howev still unclear whether sex differ heart ilc
|
D007113;D000067596;D008214;D012727;D006321
|
T129;T032;T116;T025;T023
|
36,316,643
|
structur function analysi stress induc gene promot select young oil palm elaei guineensi salt stress soil salin problem countri across contin one abiot stress threaten agricultur negat affect crop reduc product transcriptom technolog appli character transcriptom cell tissu organ given time via rna seq also known full transcriptom shotgun sequenc technolog allow identif gene express particular stage differ isoform separ transcript express level measur determin technolog express profil gene must undergo valid anoth quantit real time pcr qrt pcr studi aim select annot valid stress induc gene promot differenti express leav oil palm elaei guineensi plant salin stress
|
D018506;D028023
|
T045;T002
|
36,316,641
|
evalu qualit semi quantit cut off rapid diagnost later flow test relat serolog detect sar cov antibodi find prospect studi limit inform compar qualit semi quantit perform rapid diagnost test rdt serolog assess antibodi sever acut respiratori syndrom coronavirus sar cov therefor object studi compar efficaci sar cov antibodi detect rdt laboratori serolog tri identifi appropri semi quantit cut off rdt relat quantit serolog valu b evalu diagnost accuraci rdt compar naat gold standard unselect adult popul
|
D000086402;D000086382
|
T005;T067;T047
|
36,316,640
|
learn patient partial tracheal ruptur caus penetr neck injuri case report airway manag patient direct airway trauma caus penetr neck injuri alway challeng fail airway occur surgeri access difficult crucial find optim approach save life propos concept intub oxygen difficult surgeri access describ emerg scenario
|
D017214;D019838;D014133
|
T047;T074;T037
|
36,316,638
|
psuc edbam predict lysin succinyl site protein base ensembl dens block attent modul lysin succinyl newli discov protein post translat modif predict succinyl site help investig metabol diseas treatment howev biolog experiment approach cost ineffici necessari develop effici comput approach
|
D008239;D019802
|
T123;T121;T116;T109
|
36,316,637
|
region distribut mycobacterium tuberculosi infect resist rifampicin isoniazid determin high resolut melt analysi identifi transmiss mode resist mechan mycobacterium tuberculosi mtb key prevent diseas transmiss howev lack region data therefor aim studi identifi risk factor associ transmiss mtb region pattern resist isoniazid inh rifampicin rfp well preval multidrug resist tuberculosi mdr tb
|
D018088;D009169
|
T047;T007
|
36,316,635
|
development regul mitochondri biogenesi cell death compet maiz pollen cytoplasm male steril cms matern inherit failur produc function pollen common result express novel chimer mitochondri gene zea may cytoplasm male steril type cms character collaps immatur bi cellular pollen molecular cellular featur develop cms normal n cytoplasm pollen compar determin role mitochondria differ development fate
|
D003313;D001678
|
T168;T070;T002;T043
|
36,316,634
|
compar epidemiolog five wave covid mexico march august mexican institut social secur imss largest health care provid mexico cover mexican popul report describ epidemiolog pattern relat confirm case hospit intub hospit mortal due covid associ factor five epidem wave record imss surveil system
|
D000086382
|
T047;T067
|
36,316,633
|
current state practic variat use meningitisenceph filmarray panel children meningitisenceph filmarray panel panel approv us food drug administr provid rapid result assess patient suspect mening enceph patient evalu various subspecialti includ pediatr hospit medicin phm pediatr emerg medicin pem pediatr infecti diseas pediatr intens care unit picu physician object studi evalu current use panel describ provid subspecialti practic variat
|
D008581;D004660;D010820
|
T047;T097
|
36,316,632
|
genom wide detect rna edit event hair follicl cycl tianzhu white yak hair coat avail yak live harsh environ plateau besid improv hair product yak necessari textil industri develop hair grow hair follicl hfs hfs undergo period growth birth regul complex gene regulatori network howev molecular mechan hfs regener tianzhu white yak remain unclear rna edit post transcript mechan regul gene express produc new transcript henc investig influenc rna edit event hfs cycl tianzhu white yak
|
D018859;D017393
|
T045;T023
|
36,316,630
|
drug relat advers event potenti predict efficaci apatinib advanc hepatocellular carcinoma hepatocellular carcinoma hcc fourth lead caus cancer relat death worldwid everi year hcc patient diagnos advanc diseas receiv system treatment tkis import compon system treatment hcc good efficaci advers event ae method analysi includ patient local advanc unresect metastat hcc receiv oral treatment apatinib analyz overal surviv os progress free surviv pfs patient without correspond ae evalu ae predict efficaci apatinib
|
D006528;D008113;D000970
|
T121;T191;T109
|
36,316,629
|
method obtain exact singl step gblup non genotyp descend genom relationship matrix ancestor avail singl step genom best linear unbias predict gblup involv joint analysi individu genotyp inform ancestor descend contemporari without record genotyp livestock applic typic repres popul fewer individu genotyp relat number genotyp breed programm structur consist nucleus tier select drive genet gain propag descend repres parent multipli commerci tier case genotyp nucleus tier proprietari breed compani public avail whole industri analysi bayesian infer involv combin defin descript prior inform new inform generat posterior distribut contain avail inform paramet interest natur extens bayesian analysi would use inform posterior distribut defin prior distribut subsequ analysi
|
D016678;D023281
|
T091;T028
|
36,316,617
|
clinic applic concentr growth factor membran seal socket alveolar ridg preserv random control trial purpos studi evalu efficaci concentr growth factor cgf membran seal alveolar socket alveolar ridg preserv arp total patient alveolar socket recruit divid random cgf group bio gide collagen membran group soft tissu wound heal rate calcul use intraor scanner day arp bone resorpt volum mm alveolar ridg measur cbct month postoper keratin gingiv width also measur month ridg preserv term soft tissu heal rate cgf group exhibit signific higher bio gide group day surgeri p therefor use cgfs membran wound closur arp reliabl method clinic data need prove
|
D000540;D001862
|
T061;T042
|
36,316,610
|
simultan evalu dissolut absorpt studi compound danshen tablet capsul base cellular electr sens model studi explor dissolut mechan absorpt process compound danshen tablet cdts compound danshen capsul cdcs vitro take cell index evalu index dissolut absorpt multi compon solid prepar cdts cdcs break idea tradit research use real time cell base assay rtca provid new idea method consist evalu tradit chines medicin tcm compound prepar drug dissolut absorpt simul system ddass establish obtain dissolut absorpt sampl compound danshen solid prepar differ time point cell index ci sampl hc cell detect rtca technolog dissolut absorpt percentag calcul base index obtain dissolut absorpt kinet model meanwhil one batch tablet one batch capsul batch number zkc select conduct overal anim pharmacodynam experi verifi feasibl drug effect evalu cell index indic best fit model dissolut curv batch cdts cdcs weibul model good correl r dissolut absorpt pharmacodynam curv base rtca technolog establish comprehens evalu method cell biolog compound danshen solid prepar line overal concept tcm synchron evalu system dissolut absorpt vitro new tcm compound solid prepar
|
D027561;D004365
|
T123;T121;T002
|
36,316,597
|
allogen shell techniqu alveolar ridg augment multicent case seri experi case allogen cortic bone plate cp might use alveolar ridg augment altern autogen graft ag bone substitut bs report multicent case seri experi case use cp shell techniqu reconstruct alveolar process illustr surgic key step variat complic manag
|
D000540;D018786;D018380
|
T061;T122
|
36,316,596
|
character bioactiv substanc involv induct bone augment use deminer bone sheet investig bone augment abil deminer bone sheet mix allogen bone protein fraction contain bioactiv substanc interact coexist bioactiv substanc protein
|
D016212;D010513
|
T123;T023;T116;T030
|
36,316,594
|
analysi prognost factor patient brain metastas affect surviv brain metastas bm associ dismal prognosi caus signific morbid affect qualiti life patient manag bm depend follow factor age patient perform size number lesion locat tumor comorbid primari tumor type extracrani diseas burden present studi pattern occurr clinic characterist treatment outcom brain metastas factor tumor characterist treatment may impact bm patient overal surviv analyz
|
D001932;D016634
|
T061;T191
|
36,316,591
|
bacteri divers loggerhead green turtl egg two major nest beach turkish coast mediterranean studi conduct nest season sugz beach adana turkey gksu delta mersin turkey egg sampl n loggerhead green turtl nest n collect isol bacteria initi identifi phenotyp method maldi tof ms bacteri mass spectra analyz use princip compon analysi bacteri isol perform isol belong genera two major nest site sugz beach bacteria speci belong enterobacteriacea gksu delta bacteria speci belong morganellacea klebsiella oxytoca staphylococcus haemolyticus previous detect sea turtl nest first maldi tof ms studi conduct determin bacteri variabl loggerhead turtl egg turkey serv refer studi assess bacteri threat sea turtl nest enabl establish suitabl conserv measur treatment process sea turtl nest site
|
D014426
|
T014
|
36,316,590
|
product halotoler endo glucanas newli isol bacillus velezensi h oliv mill wast without pretreat purif character enzym face critic issu high product cost cellulas numer studi focus improv effici cellulas product potenti cellulolyt microorgan use agricultur wast substrat extremophil cellulas particular crucial biorefineri process maintain activ harsh environment condit studi aim investig abil potenti carboxymethylcellulos hydrolyz bacteri strain h isol algerian salin soil identifi bacillus velezensi use untreat oliv mill wast substrat product endo glucanas enzym purifi fold use two step ultrafiltr concentr ion exchang chromatographi final recoveri molecular mass estim kda sds page enzym identif lc ms analysi show ident endo glucanas gh famili highest enzymat activ signific measur barley glucan uml follow lichenan carboxymethylcellulos substrat confirm studi enzym endo glucanas optim enzymat activ ph c fair thermotoler retain activ c halotoler retain activ presenc nacl enzym v max uminml high affin barley glucan result k mgml also show signific abil releas cello oligosaccharid base data h endo glucanas may signific commerci valu industri argo wast treatment biotechnolog applic
|
D002480;D031658;D047071
|
T121;T116;T109;T168;T126;T002
|
36,316,588
|
evalu weather paramet base pre harvest yield forecast model wheat crop case studi saurashtra region gujarat wheat import food grain cultiv mani indian state punjab haryana uttar pradesh madhya pradesh contribut major crop product india studi popular statist approach multipl linear regress mlr time seri approach time delay neural network tdnn arimax model envisag wheat yield forecast use weather paramet case studi area ie junagarh district western gujarat region situat foot mount girnar weather data correspond week nd th standard meteorolog week smw crop grow season use predict wheat yield use statist techniqu evalu predict capabl furthermor trend analysi among weather paramet crop yield also carri studi use non parametr mann kendal test sen slope method signific negat correl observ wheat yield week weather variabl viz maximum temperatur th smw total rainfal st smw posit correl observ morn relat humid rd smw studi indic forecast error vari mlr arimax tdnn model train period mape valu show time seri data predict less variat wherea convent mlr techniqu indic variat arimax tdnn approach indic better perform model train period ie former perform well forecast period overal studi indic arimax approach use consist year use model
|
D014908;D004784
|
T168;T002;T057
|
36,316,563
|
incorpor imag format process deep learn improv network perform present richardson luci network rln fast lightweight deep learn method three dimension fluoresc microscopi deconvolut rln combin tradit richardson luci iter fulli convolut network structur establish connect imag format process therebi improv network perform contain rough paramet rln enabl four fold faster process pure data driven network mani paramet visual quantit analysi show rln provid better deconvolut better generaliz fewer artifact network especi along axial dimens rln outperform classic richardson luci deconvolut volum contamin sever focus fluoresc nois provid four sixfold faster reconstruct larg clear tissu dataset classic multi view pipelin demonstr rln perform cell tissu embryo imag widefield light sheet confoc super resolut microscopi
|
D000465;D000077321
|
T170;T066
|
36,316,540
|
structur molecular determin candida glabrata metacaspas matur activ calcium metacaspas caspas like homolog undergo complex matur process involv multipl intra chain cleavag result composit enzym made p p domain proteolyt activ involv cystein histidin catalyt dyad show peptid bond cleavag specif c termin lysin arginin matur catalyt process calcium depend present structur metacaspas yeast candida glabrata cgmca complex uniqu calcium along structur three magnesium ion bound show ca ion interact loop vicin catalyt site reorgan cation bind loop bring togeth two catalyt residu could one main structur determin trigger metacaspas activ enzymat explor cgmca confirm matur process impli tran mechan sequenti cleavag
|
D002118;D041221
|
T123;T196;T121;T004
|
36,316,537
|
mechan prey divis stripe marlin marin group hunt predat mani terrestri group hunter cooper kill prey compet share domin strong predictor prey divis contrast littl known prey divis group hunt marin predat predomin attack small evas prey eg fish school identifi individu stripe marlin kajikia audax hunt group group surround prey individu took turn attack found competit prey access led unequ divis prey among predat frequent attack marlin captur fish neither aggress bodi size variat hunt effici explain skew prey divis find newli arriv group marlin gain averag access prey rais possibl newli arriv marlin hungrier motiv feed howev result necessarili explain unequ prey divis among predat skew prey captur found level group dynam prey divis probabl widespread report marin group hunter inabl individu monopol prey satiat like reduc import social hierarchi prey divis
|
D011235;D010473
|
T054;T013
|
36,316,534
|
novel method monitor covid fatal rate real time key metric guid public health polici accur estim real time fatal rate warrant monitor progress ongo epidem henc facilit polici make process howev exist estim fail captur time vari natur fatal rate often bias practic simpl real time fatal rate estim adjust report delay propos paper use fuse lasso techniqu approach easi use broad appli public health practic basic epidemiolog data requir larg scale simul studi suggest propos estim reliabl benchmark formul public health polici epidem high accuraci sensit captur chang fatal rate time two common use case fatal rate estim may convey delay even mislead signal true situat applic covid data germani januari januari demonstr import social restrict earli phase pandem vaccin avail benefici effect vaccin suppress fatal rate low level sinc august irrespect rebound infect driven infecti delta omicron variant fourth wave
|
D000086382
|
T047;T067
|
36,316,531
|
impact adapt mitig climat chang indian agricultur climat chang pose serious risk indian agricultur half agricultur land countri rainf climat chang affect crop yield soil process water avail pest dynam sever adapt strategi heat water stress toler crop varieti stress toler new crop improv agronom manag practic improv water use effici conserv agricultur practic improv pest manag improv weather forecast climat servic place minim climat risk agricultur sector contribut greenhous gas ghg countri mitig ghg emiss agricultur achiev chang land use manag practic enhanc input use effici experi india show methan emiss lowland rice field reduc altern wet dri awd grow shorter durat varieti use neem coat urea accord soil health card shc leaf color chart lcc dri direct seed rice requir continu soil submerg reduc methan emiss sequestr carbon c agricultur soil promot applic organ manur crop residu balanc nutrient india taken sever proactiv step address issu climat chang agricultur recent also commit reduc ghg emiss intens achiev net zero emiss paper discuss major impact climat chang potenti adapt mitig option initi govt india make indian agricultur climat smart
|
D000074382;D012275
|
T168;T197;T002
|
36,316,530
|
differenti express regul hsp gene growth phase rumin respons heat stress heat shock protein regul physiolog mechan heat stress adapt cellular level present investig carri analys hsp gene regul various growth stage rumin peripher blood mononuclear cell pbmcs relationship hsp gene express thermotoler age specif manner rumin analys therefor rna hsp express level examin differ age group jamunpari goat hot climat condit experi carri anim jamunapari goat belong age group month month month adult year total rna isol peripher blood mononuclear cell physiolog respons rectal temperatur rt respir rate rr heart rate hr use indic heat stress temperatur humid index thi use indic sever environment stress thi rang vari experiment period rna hsp express level month age anim regul signific higher age group observ level hsp transcript pbmcs highest month age group age relat declin hsp express observ adult age base physiolog respons contrast heat stress phenotyp recognis heat stress suscept hss heat stress toler hst individu express rna hsp analys differ age respons chronic heat stress differenti mrna express hss individu month age show highest fold express hst age phenotyp signific effect p cross point cp valu rna hsp gene express differ age group correl heat stress toler could use biomark breeder analys hsp respons vivo rumin
|
D007963;D018882
|
T025;T037
|
36,316,529
|
integr insight clinic applic singl cell sequenc cancer immunotherapi recent immunotherapi gain increas popular oncolog sever immunotherapi obtain remark clinic effect efficaci vari subset cancer patient benefit break constraint improv immunotherapi efficaci extrem import precis medicin wherea tradit sequenc approach mask characterist individu cell singl cell sequenc provid multipl dimens cellular character singl cell level includ genom transcriptom epigenom proteom multi omic henc complex tumor microenviron univers tumor heterogen cell composit cell cell interact cell lineag track tumor drug resist mechan reveal depth howev clinic transform singl cell technolog point depth studi especi applic immunotherapi newli discov vital cell tremend biomark facilit develop effici individu therapeut regimen guid clinic treatment predict prognosi review provid overview progress distinct singl cell sequenc method emerg strategi perspect expand util combin singl cell sequenc technolog discuss
|
D040901;D009369
|
T191;T091
|
36,316,528
|
analys carbon atom diffus grey cast iron carburis process studi employ fick second law diffus discov unknown aspect carbon diffus grey cast iron carburis process emphasi experi theoret model establish better accomplish pulveris palm kernel eggshel addit wt wt accord voig law mixtur consid continu medium without consid atom natur mixtur furthermor kinet approach describ physic model substrat immers carbon mixtur establish diffus equat model establish mechan carbon diffus carburis initi composit concentr diffus atom remain constant carbon carbur time use vari min min min min min min respect constant carburis temperatur result reveal vari composit gradient carbon atom rang compar initi carbon content concentr carbon atom substrat surfac vari time impli process non steadi state diffus verifi fick second law diffus henc composit achiev function boundari condit time posit temperatur novel studi enhanc understand heat treat treatment metal applic industri numer
|
D002244;D007501
|
T121;T196;T123
|
36,316,525
|
channel receiv array coil allow whole heart cine mri two breath hold new channel receiv array coil sensit encod compress c sens noncompress sens investig decreas number breath hold bhs cardiac magnet reson cmr
|
D019028;D062485
|
T060;T033
|
36,316,524
|
osteopenia associ inferior surviv patient undergo partial hepatectomi hepatocellular carcinoma osteopenia known associ clinic frailti link inferior outcom various clinic scenario howev exact prognost valu osteopenia patient undergo curat intent surgeri hepatocellular carcinoma hcc complet understood retrospect studi conduct cohort patient underw partial hepatectomi hcc curat intent german univers medic center preoper comput tomographi base segment use assess osteopenia prognost impact patholog chang bone miner densiti bmd periop morbid mortal long term oncolog outcom analyz five year overal surviv osteopen patient signific wors compar normal bmd vs p line probabl diseas free surviv year signific wors patient osteopenia vs p multivari model osteopenia confirm independ risk factor inferior overal surviv hazard ratio p concern periop complic osteopen patient perform slight wors even though statist differ detect clavien dindo b vs p present studi confirm osteopenia independ risk factor inferior surviv patient undergo partial hepatectomi hcc european cohort studi warrant valid find
|
D006528;D008113;D001851
|
T047;T191
|
36,316,522
|
qualiti safeti investig common use topic cosmet prepar cosmet person care product consid essenti part daili care routin henc product must stabl safe human use studi aim assess qualiti safeti common cosmet prepar select product test cross section survey distribut featur use type brand product base respons male femal differ age educ level product differ brand select test term microbi load heavi metal content organolept properti microbi contamin investig use aerob plate count method lead pb aluminum al cadmium cd cobalt co chromium cr copper cu manganes mn nickel ni zinc zn iron fe arsenic impur analyz use induct coupl plasma mass spectromet product includ sunblock lip balm hand cream hair cream shampoo cleanser babi oil babi powder bar soap hair dye makeup deodor hair serum shave gel toothpast microbi contamin found product rang cfuml common isol microorgan staphylococcus aureus bacillus speci test product show metal impur toothpast highest concentr pb cr cu ni sampl show lump discolor characterist odor ph valu rang continu usag product could lead serious negat consequ result ensur qualiti cosmet product critic regulatori author requir enforc strict legisl cosmet manufactur assess ensur qualiti safeti product reach consum
|
D019216;D003358;D001151
|
T121;T073;T131;T196;T167
|
36,316,521
|
magnet target fluorouracil load liposom nanogel vivo breast cancer therapi cytotox effect liver kidney previous paper demonstr ex vivo studi non toxic liposom nanogel system long term drug releas could provid hybrid system fluorouracil fu drug molecul aim studi vivo magnet target fu load fe nanoparticl includ dppc liposom base pegyl nanogel fu load fe lpn breast cancer tissu investig treatment cytotox effect hybrid system liver kidney cd mice use extern magnet field effect control fu group fe lpn fu load fe lpn system evalu use histopatholog term p esr prg c erb qrt pcr term tym esr rpg egrf also cytotox analyz histopatholog evalu kidney liver tissu caspas caspas evalu perform qrt pcr creatinin alt level also evalu compar blood sampl group total nm tem size fe lnp hybrid system success prepar system signific decreas tym esr level treatment process increas level p express level caspas mrna chang treatment level caspas mrna level signific decreas magnet target liposom base nanogel hybrid system promis effect therapi breast tumor less liver kidney damag fe lnp hybrid system could use similar small molecul
|
D000970;D053758
|
T121;T073;T109
|
36,316,520
|
innov binari sorption cobalt ii methylen blue sargassum latifolium use taguchi hybrid artifici neural network paradigm present investig design taguchi hybrid artifici neural network ann paradigm improv optim binari sorption cobalt ii methylen blue mb aqueous solut depend modifi physicochem condit generat appropri constitut high effici biosorpt alga sargassum latifolium concern taguchi design predict valu two respons compar actual one biosorpt cobalt ii ion effici mb suprem biosorpt cobalt ii verifi run l highest sn ratio highest biosorpt mb reach run l sn ratio r adjust r reason valu indic valid model hybrid ann model exclus emerg herein optim biosorpt cobalt ii mb simultan therefor ann model better taguchi design predict valu cobalt ii mb biosorpt obedi ann model sem analysi surfac latifolium show mosaic form massiv particl crosslink biomolecul algal surfac presenc cobalt ii mb view ftir analysi show activ group eg hydroxyl unsatur ester unsatur keton n aromat amin best knowledg report deem binari sorption cobalt ii mb ion latifolium taguchi orthogon array hybrid ann
|
D044647;D014874
|
T131;T204
|
36,316,518
|
increas retin drusen iga glomerulonephr evid complement activ diseas pathogenesi drusen retin deposit compris cell debri immun materi complement characterist macular degener also found glomerulonephr pilot cross section studi determin often drusen occur iga glomerulonephr clinic signific studi particip underw non mydriat retin photographi deidentifi retin imag examin drusen two train grader compar central drusen count count drusen size match control cohort compris individu iga glomerulonephr includ male individu east asian southern european ancestri overal median age year median diseas durat year thirti nine egfr mlmin previous reach kidney failur overal mean drusen count higher iga glomerulonephr control p central count also common p associ longer diseas durat p kidney failur p larger drusen associ mesangi iga stain p increas drusen count also present iga glomerulonephr secondari crohn diseas henoch schonlein purpura find retin drusen iga glomerulonephr consist complement activ repres model better understand glomerular immun deposit support argument treatment anti complement therapi
|
D015593;D005922;D011695;D005921
|
T047
|
36,316,516
|
function tooth number posterior region associ serum ucoc level purpos studi investig serum undercarboxyl osteocalcin ucoc level partial edentul patient schedul receiv implant treatment determin associ ucoc level veget intak vitamin k dietari fiber intak function tooth number posterior region p ftn
|
D014812;D009752
|
T033;T121;T127;T109
|
36,316,504
|
within across countri assess genom divers autozygos south african eswatini nguni cattl southern africa nguni cattl breed classifi indigen transboundari anim genet resourc angr manifest uniqu adapt abil across distinct agroecolog zone genet integr various ecotyp potenti threat due indiscrimin crossbreed uncontrol inbreed aim studi assess genet divers autozygos exist across countri es eswatini sa south africa within countri sa purebr stud anim sa research herd sa r subset es sa sa r genotyp common snps use studi genom wide profil run homozygos roh heterozygos rohet well inbreed level popul structur highest percentag roh segment mbp length wherea rohet segment fell within mbp length categori inbreed coeffici indic posit low inbreed f roh mbp rang sa sa r princip compon pca popul structur analys illustr genom level distinct nguni global indicin boran taurin hereford breed k sa nguni popul es nguni popul k differ nguni ecotyp within countri k furthermor greater admixtur observ sa r popul compar purebr sa popul share ancestri compar fewer genom defin es ecotyp observ phenotyp pre defin overal result illustr genet uniqu within sampl nguni cattl result geograph isol exposur differ breed strategi select pressur loss genet variabl monitor prevent endanger uniqu benefici ecotyp
|
D016678;D007178
|
T040;T028
|
36,316,502
|
bacteri chitinas genet engin applic chitinas group enzym catalyz chitin hydrolysi present domain life chitinas belong differ glycosyl hydrolas famili great divers sequenc microorgan bacteria fungi produc chitinas nutrit energi parasit chitin host chitinas bacteria special interest due ubiquit natur abil perform extrem condit chitinas produc bacteria explor use agricultur industri agricultur main role control chitin contain insect pest fungal pathogen nematod seafood industri found role manag process wast main chitin substanc chitinas also use synthes low molecular weight chitooligom proven bioactiv compound activ anti tumour antimicrobi immun modul consid import ecolog biotechnolog applic sever bacteri chitinas studi last two decad despit potenti bacteri chitinas limit low product lack secret system make wild type enzym unfit applic industri alli sector review attempt collat signific work bacteri chitinas applic various industri employ various tool techniqu improv meet industri requir
|
D001419;D002688
|
T007;T126;T116
|
36,316,488
|
impact extrem weather event cropland inund indian subcontin cyclon storm extrem precipit lead loss live signific damag land properti crop product etc gulab cyclon storm form th septemb bay bengal bob hit eastern indian coast th septemb caus massiv damag water inund studi use integr multi satellit retriev gpm imerg satellit precipit data daili month scale assess focus gulab cyclon event otsu threshold approach appli sentinel data map water inund standard precipit index spi employ analyz precipit deviat compar year mean climatolog across india june novemb month scale water inund area overlaid recent public avail high resolut land use land cover lulc map demarc crop area damag four eastern indian state andhra pradesh chhattisgarh odisha telangana maximum water inund crop area damag observ andhra pradesh km follow telangana km odisha km least chhattisgarh km studi potenti implic emerg respons extrem weather event cyclon extrem precipit flood spatio tempor data layer rapid assess methodolog help various user disast manag author mitig respons team crop insur scheme develop relev satellit data product cloud comput facil could operation systemat disast monitor rise threat extrem weather event come year
|
D000080165
|
T070
|
36,316,473
|
higher visual gain contribut bilater motor synergi forc control studi investig effect alter visual gain level bilater motor synergi determin uncontrol manifold ucm hypothesi forc control twelv healthi particip perform bimanu index finger abduct forc control task maxim voluntari contract across four differ visual gain condit pixelsn quantifi forc accuraci variabl within trial provid bimanu forc control outcom ucm analysi measur bilater motor synergi proport good varianc bad varianc across multipl trial correl analys determin whether chang ucm variabl relat chang forc control variabl lowest highest visual gain condit respect multipl analys indic three highest visual gain condit comparison lowest visual gain increas valu bilater motor synergi target forc accuraci correl find show reduct bad varianc lowest three highest visual gain condit relat increas forc accuraci find reveal visual gain greater pixelsn facilit bimanu forc control
|
D011597;D005385
|
T023;T041
|
36,316,463
|
interact blood pressur genet risk score bladder cancer risk urotheli carcinoma men substanti genet predisposit bladder cancer bc recent blood pressur bp posit associ bc risk men potenti interact genet suscept bc unknown investig weight genet risk score wgrs bc genet variant bp interact relat incid urotheli cancer uc n risk men use cox regress likelihood ratio test relat excess risk interact calcul hazard ratio hr uc multipl interact addit interact respect evid posit addit interact sbp wgrs relat aggress p non aggress p uc hr aggress uc sbp mmhg upper wgrs combin ci compar counterpart group addit year risk aggress uc year old men low sbplow wgrs group high sbphigh wgrs group find support potenti addit interact wgrs sbp aggress uc among men replic find interact may provid biolog public health insight prevent aggress uc
|
D002295;D001749
|
T191
|
36,316,461
|
identif repurpos drug target signific long non code rnas cross talk diabet mellitus alzheim diseas relationship diabet mellitus dm alzheim diseas ad strong scientist call brain diabet accord sever studi critic factor relationship brain insulin resist due rapid global spread diseas overcom cross talk signific impact societi long non code rnas lncrnas hand substanti impact complex diseas due abil influenc gene express via varieti mechan consequ regul lncrna express chronic diseas permit develop innov therapeut techniqu howev develop new drug requir consider time money recent repurpos exist drug gain popular due use low risk compound may result cost time save studi identifi drug repurpos candid capabl control express common lncrnas cross talk dm ad also util drug interf cross talk high degre common lncrnas extract microrna lncrna bipartit network drug interact specifi lncrnas collect multipl data sourc drug refer set classifi posit negat group base effect express interact lncrnas featur select algorithm use select six import featur use random forest classifi featur capabl classifi accuraci final six featur extract recent food drug administr fda approv drug order identifi highest likelihood belong signific fda approv posit drug chromium nicotin tapentadol present repurpos candid cefepim dihydro alpha ergocryptin recommend signific advers drug moreov two natur compound curcumin quercetin recommend prevent cross talk accord previous studi less attent paid role lncrnas cross talk research identifi import lncrnas also suggest potenti repurpos drug control
|
D062085;D000544;D035683;D003920
|
T123;T047;T114;T048
|
36,316,456
|
post oper prophylact antibiot asept revis hip knee arthroplasti propens score match analysi use extend antibiot ea prophylaxi h remain controversi asept revis arthroplasti sought determin whether ea prophylaxi reduc risk periprosthet joint infect pji asept revis hip knee arthroplasti total patient undergo asept revis hip knee arthroplasti five institut databas evalu one two nearest neighbor propens score match analysi conduct patient receiv extend antibiot prophylaxi match element includ age sex bodi mass index charlson comorbid index hospit distribut year surgeri joint hip knee surgic time crp preoper hemoglobin albumin length stay primari outcom develop pji assess day day year follow revis analyz separ total patient receiv ea prophylaxi patient receiv standard antibiot sa prophylaxi h propens match analysi differ patient receiv ea prophylaxi term day pji vs p day pji vs p year pji vs p revis hip incid pji vs day p vs day p vs year p ea sa group revis knee incid pji vs day p vs day p vs year p ea sa group post hoc power analysi reveal adequ sampl size beta valu addit risk clostridium difficil resist organ infect increas multi institut studi demonstr differ rate pjis patient receiv extend antibiot prophylaxi asept revis arthroplasti risk c difficil resist organ infect increas prolong antibiot use
|
D019645;D016459;D019644;D016360;D001170
|
T061;T047;T046;T007
|
36,316,453
|
impact acceler deploy offshor windfarm near surfac climat european union set ambiti goal becom climat neutral stimul renew energi product acceler deploy offshor wind energi north sea high resolut region climat model use investig impact sea surfac climat larg scale offshor wind farm propos north sea result show signific reduct air sea heat flux local annual mean net cool lower atmospher wind farm area wm due decreas wind speed turbul kinet energi increas low level cloud mean surfac wind decreas approxim ms downstream wind farm furthermor increas approxim mean precipit found wind farm area season timescal differ higher winter autumn season although offshor wind farm reduc heat transport ocean atmospher region larg wind farm atmospher layer hub height show increas temperatur order climat chang signal end centuri much smaller interannu climat variabl contrast wind speed chang larger project mean wind speed chang due climat chang result suggest impact larg cluster offshor wind farm consid climat chang impact studi moreov identifi offshor windfarm impact sea surfac climat introduc spatial pattern atmospher condit particular model wind speed chang suggest potenti impact local ocean dynam structur marin ecosystem consid futur scenario north sea marin environ taken account structur influenc offshor environ
|
D017753;D004736
|
T070;T169;T082
|
36,316,450
|
regist report social face evalu ethnic specif differ judgement trustworthi face facial part social face evalu common consequenti element everyday life base judgement trustworthi howev particular facial region guid trustworthi judgement larg unknown also unclear whether differ facial region consist util guid judgment differ ethnic group whether previous exposur specif ethnic one social environ influenc trustworthi judgement made face facial region regist report address question global onlin survey studi recruit asian black latino white rater n rater shown full face specif part face ethnic divers sex balanc set target rate target trustworthi multilevel model show form trustworthi judgement rater reli strong eye substanti inform loss vis vis full face corrobor ingroup outgroup effect rater rate face facial part target share ethnic sex eye color signific trustworthi exposur ethnic group rater social environ predict trustworthi rate ethnic group nuanc way rater ambient ethnic major provid slight higher trustworthi rate stimuli ethnic compar minor ethnic contrast rater ambient ethnic minor eg immigr provid substanti lower trustworthi rate stimuli ethnic major taken togeth current studi provid new window psycholog process under social face evalu cultur generaliz protocol registr stage protocol regist report accept principl januari protocol accept journal found https doiorgmfigshar
|
D007600;D005006
|
T098;T102;T041
|
36,316,449
|
select hallmark hallux valgus older women symptomat hallux valgus compar middl age women without deform forefoot aim studi compar shape feet mobil metatarsophalang interphalang joint flexibl calf muscl older women hallux valgus versus middl age women without deform identifi presenc featur correl particular strong hallux valgus prophylaxi conserv treatment focus studi involv women age year hallux valgus toe age hallux valgus toe age year correct shape feet intens pain foot valgus angl big toe fifth toe longitudin transvers arch foot symmetri foot load bodi weight toe joint mobil muscl flexibl analys group women hallux valgus differ women normal feet height transvers arch extent dorsal extens first metatarsophalang joint plantar flexion first interphalang joint older women addit characteris reduc plantar flexion metatarsophalang joint big toe limit flexibl soleus gastrocnemius muscl well less pain toe area foot characterist chang observ older women hallux valgus limit rang motion mtp ip joint big toe reduc transvers arch increas restrict calf muscl flexibl
|
D006215;D008683
|
T190;T030
|
36,316,445
|
season methan emiss municip solid wast dispos site lago nigeria municip solid wast msw sector major sourc methan ch emiss greenhous gas ghg contribut climat chang howev govern develop countri abl address challeng pose sector due inadequ fund technic requir object studi determin season variat influenc ch gas emiss first order decay fod tier model use estim ch emiss four solid wast dispos site swds lago name ewu elep ewu abul egba ae soluo sol olushosun olu cover dri wet season respect inventori year known weight wet wast deposit character studi reveal degrad organ carbon doc dri season ggckgwast wet season ggckgwast methan gas generat wet season gg higher dri season gg studi period appreci quantiti methan contribut global climat chang impact address therefor wast type segreg recycl process compost energi resourc
|
D008697;D012037
|
T057;T109
|
36,316,441
|
new insight swim kinemat wild green sea turtl chelonia myda biomechan sea turtl could perceiv bird ocean glide flap forelimb produc necessari forc requir locomot make sea turtl interest anim studi howev endang speci make studi sea turtl biomechan complex problem solv technic ethic without caus disturb work develop novel non invas procedur develop full three dimension kinemat wild sea turtl film anim australia great barrier reef use underwat drone without disturb found wild anim differ swim pattern previous studi juvenil captiv find show flipper goe close loop trajectori extend sweep flipper tip toward centr carapac creat clap motion name sweep stroke contrast previous describ four stage model creat five stage cycl swim locomot model model present could lead better comprehens sea turtl propuls method fluid structur interact
|
D014426
|
T014
|
36,316,440
|
rewir glucos metabol improv fu efficaci p deficientkra gd glycolyt colorect tumor despit fact fluorouracil fu backbon chemotherapi colorect cancer crc respons rate patient limit mechan under fu toxic debat limit develop strategi improv efficaci fundament aspect cancer driver mutat phenotyp heterogen relat fu respons remain obscur larg reli limit number studi perform pre clinic model abl recapitul key featur crc analyz fu respons patient deriv organoid reproduc differ stage crc find fu induc pyrimidin imbal lead dna damag cell death activ prolifer cancer cell defici p import p defici lead cell death due impair cell cycl arrest moreov find target warburg effect kras gd glycolyt tumor organoid enhanc fu toxic alter nucleotid pool import without affect non transform wt cell thus p emerg import factor determin fu respons target cancer metabol combin replic stress induc chemotherapi emerg promis strategi crc treatment
|
D016159;D015179
|
T123;T191;T116
|
36,316,438
|
posit surgic margin impact short term oncolog prognosi robot assist partial nephrectomi margin studi uroccr oncolog impact posit surgic margin psm robot assist partial nephrectomi rapn still debat compar psm negat surgic margin nsm term recurr free surviv rfs metastasi free surviv mfs overal surviv os rapn identifi predict factor psm multi institut studi use uroccr databas prospect includ rapn april februari cnil dr nct two group retrospect compar psm versus nsm prognost factor assess use kaplan meyer curv log rank test cox hazard proport risk model logist regress univari comparison patient psm nsm median follow month rapn recurr report kaplan meier curv analysi suggest rfs mfs os affect psm p respect multivari analysi predictor psm lower renal score p longer warm ischemia time wit p chromophob renal cell carcinoma chrrcc p studi found impact psm rfs mfs os predictor psm renal score wit chrrcc
|
D007680;D012371
|
T090;T191
|
36,316,436
|
amino acid prevent mortal morbid preterm infant systemat review network meta analysi determin effect safeti amino acid prevent mortal morbid among preterm infant conduct systemat review network meta analysi search medlin embas web scienc cinahl scopus cochran googl scholar grey literatur databas incept januari includ random trial evalu amino acid preterm low birth weight infant perform frequentist pairwis network meta analys use grade methodolog assess certainti evid provid summari resultsw includ trial infant low certainti evid show seem benefit arginin glutamin n acetylcystein reduc caus mortal oral arginin like result reduct necrotizin enterocol nec stage ii ci moder certainti oral glutamin may reduc likelihood develop late onset sepsi los compar placebo ci low certainti like reduc time reach full enter feed md day ci moder certainti amino acid may effect mortal oral arginin may reduc sever nec oral glutamin may reduc los time reach full feedingsystemat review registr prospero registr number crd
|
D020345;D018805
|
T047;T046
|
36,316,435
|
hereditari spastic paraplegia spg mutat increas structur stabil atpas activ human mitochondri chaperonin human mitochondri chaperonin mhsp broad associ various human health condit vi mutat mhsp caus form hereditari spastic paraplegia neurodegen diseas main function mhsp assist fold mitochondri protein atp depend manner studi unexpect found mutant mhsp vi stabl structur activ atpas activ wildtyp analysi recent solv cryo em structur mhsp reveal alloster role vi structur stabil atpas activ support studi includ use va mutat despit increas structur stabil atpas activ mhsp vi less effici fold malat dehydrogenas putat mhsp substrat protein mitochondria also common use chaperonin studi addit although mhsp vi along cochaperonin mhsp abl substitut e coli chaperonin system support cell growth normal temperatur c unabl heat shock temperatur c result support import structur dynam optim atp turnov mhsp evolv function physiolog propos unproduct energi util hyperact atpas activ compromis fold function mutual exclus respons vi patholog neurodegen diseas
|
D015419;D019636
|
T047
|
36,316,434
|
valu comput tomographi hounsfield unit predict pedicl screw loosen thorac spine evalu feasibl use hounsfield unit hu valu vertebr bodi predict screw loosen thorac spine consecut patient underw thorac spinal fusion surgeri retrospect identifi patient pedicl screw loosen upper instrument vertebra uiv postop comput tomographi includ loosen group control group compris equal number age sex uiv match patient without screw loosen preoper hu valu uiv lumbar score compar group receiv oper characterist curv construct hu valu score predict screw loosen best cutoff valu determin statist analys perform subgroup ie upper lower thorac level forti six patient includ loosen control group signific group differ hu valu note lower thorac uiv loosen control p upper thorac uiv loosen control p score differ group lower p upper p thorac uiv lower thorac uiv area receiv oper characterist curv hus p confid interv ci p ci score optim cutoff valu hus use cutoff hu valu show better posit predict valu negat predict valu accuraci compar score predict screw loosen
|
D065289;D013123
|
T061;T074
|
36,316,432
|
efficaci safeti dulaglutid compar first line hypoglycem drug asian patient type diabet systemat review meta analysi assess efficaci safeti dulaglutid treatment asian type diabet mellitus tdm along first line hypoglycem drug systemat review meta analysi cochran librari pubm embas wwwclinicaltrialsgov databas search incept septemb studi evalu adult year undergo dulaglutid mg mg first line hypoglycem drug consid english languag use stata softwar detect risk bias random control trial rcts observ studi dulaglutid mg dose group mg dose group could signific reduc hbac dulaglutid mg wmd ci p dulaglutid mg wmd ci p asian tdm patient reduc fast blood glucos fbg level signific differ observ dose group bodi weight patient dulaglutid dose group signific reduc safeti incid advers event dulaglutid mg dose group slight higher first line drug group statist signific differ incid advers event mg dose group first line drug group furthermor incid hypoglycem event group higher first line drug group two dose dulaglutid show better efficaci asian tdm patient patient vigil occurr hypoglycemia gastrointestin discomfort howev number better qualiti rcts suggest confirm long term safeti efficaci
|
D007004;D003924
|
T121;T039;T047
|
36,316,431
|
sleep pattern healthi lifestyl colorect cancer incid research identifi associ lifestyl factor colorect cancer crc risk studi examin relationship sleep pattern crc event individu sampl uk biobank chronotyp sleep durat insomnia snore excess daytim sleepi combin measur healthi sleep score number healthi sleep factor defin along factor healthi lifestyl score use cox proport hazard regress comput hazard ratio hrs use examin associ sleep pattern healthi lifestyl incid crc healthi sleep score invers associ crc event hrs crc ci ci point healthi sleep score increas among male femal analyz sleep compon sleep hday frequent insomnia snore frequent daytim sleepi independ associ lower risk crc respect whilst healthi lifestyl score invers associ crc incid across model sleep pattern lifestyl signific correl crc risk healthier subject lifestyl sleep pattern lower crc risk
|
D007319;D006970;D015179
|
T184;T191;T033;T047;T048
|
36,316,430
|
search serum biomark link coronari heart diseas helicobact pylori infect use infrar spectroscopi artifici neural network helicobact pylori hp gram negat bacteria caus gastriti gastric ulcer may involv develop system diseas ie coronari heart diseas chd hp infect chd relat inflamm accompani c reactiv protein crp tumor necrosi factor alfa tnf homocystein low densiti lipoprotein ldl triglicerid classic risk factor chd infrar spectroscopi introduc monitor chronic infect endogen disord use specif absorpt band biocompon type diagnost marker studi select specif motiv infrar radiat ir spectra sera chd patient infect hp total sera use patient chd hp posit healthi donor hp negat hp posit hp status evalu anti hp igg antibodi andor c urea breath test ir spectra measur use ft irft nir spectrum spectromet perkinelm chemometr analyz use artifici neural network show differ absorpt band correspond triglicerid crp homocystein ldl tnf select compon group chd patient infect hp vs healthi uninfect donor accuraci triglicerid crp best biomark link hp infect chd
|
D016481;D016480;D005756;D003327
|
T047;T007
|
36,316,429
|
insight molecular aspect salt stress toler mycorrhiz plant salt stress one major abiot stress sever affect plant growth yield also affect livelihood peopl around world arbuscular mycorrhiz fungi amf colon major terrestri plant includ halophyt xerophyt glycophyt facilit function various physiolog biochem molecular process past two decad signific progress made understand role amf mitig salt stress improv plant growth product salin condit sever studi focus biochem physiolog mechan mycorrhiz plant employ combat salt stress carri review reinforc studi give insight molecular aspect toler salt stress plant colon amf emphasis role amf sens signal salt stress express aquaporin encod gene na h antiport transport involv na exclus cngcs late embryogenesi abund protein relat salt stress toler paper also review accrual compat osmolyt phytohormon nitric oxid understand benefit symbiosi salin environ provid benchmark inform understand contribut mycorrhiz symbiosi molecular level attract attent research develop highlight futur research program field
|
D038821
|
T004
|
36,316,425
|
persist muscl hyperalgesia adolesc stress exacerb mild nocicept input adulthood associ microglia activ non specif low back pain lbp major global diseas burden childhood advers predispos develop mechan larg unknown investig advers young rat augment mechan hyperalgesia spinal cord microglia contribut adolesc rat underw restraint stress control anim handl adulthood rat receiv two intramuscular inject ngfsalin lumbar multifidus muscl stress induc rat adolesc lower low back pressur pain threshold ppt p paw withdraw threshold pwt p lower muscl ppt persist throughout adulthood p subsequ ngf adulthood lower ppt immunohistochemistri reveal chang microglia morpholog stress follow ngf induc signific increas ameboid state p repeat ngf inject without stress show signific increas cell size surveil bushi state p thus stress adolesc induc persist muscl hyperalgesia enhanc mild nocicept input accompani morpholog chang microglia differ prime adolesc stress nocicept input novel rodent model show adolesc stress risk factor develop lbp adulthood morpholog chang microglia sign spinal mechan involv
|
D006930;D017628
|
T184;T025
|
36,316,421
|
non invas brain stimul modul gabaerg activ neurofibromatosi neurofibromatosi nf singl gene disord associ cognit phenotyp common neurodevelopment condit autism gabaerg dysregul under work memori impair seen nf mechanist experiment studi investig whether applic anod transcrani direct current stimul atdc modul gaba work memori nf thirti one nf adolesc year recruit singl blind sham control cross random trial atdc sham stimul appli left dorsolater prefront cortex dlpfc mr spectroscopi collect intervent left dlpfc occipit cortex task relat function mri collect stimul higher baselin gaba left dlpfc associ faster respons time baselin work memori measur atdc seen signific reduc gaba increas brain activ left dlpfc compar sham stimul task perform wors atdc group stimul group differ behaviour outcom observ end stimul although studi suggest atdc modul inhibitori activ dlpfc work need determin whether repeat session atdc strategi altern current stimul offer better therapeut approach
|
D009456;D065908
|
T061;T047;T191
|
36,316,420
|
quantif patholog gait paramet threshold idiopath normal pressur hydrocephalus patient clinic gait analysi aim studi distinguish hypokinet gait disord idiopath normal pressur hydrocephalus nph patient gait declin elder popul quantifi patholog gait paramet threshold util multipl condit gait assess nph patient age match healthi subject underw standard gait assess eight gait condit spatiotempor gait paramet assess pressur sensit carpet statist analysi consist binari logist regress blr model logist curv fit evalu chi squar good fit test receiv oper characterist model area curv auc invers blr discrimin gait paramet threshold observ pace gait cycl support gait domain distinct gait condit prefer walk speed semant dual task prefer walk speed signific gait paramet threshold stride length sensit specif auc gait veloc ms doubl support phase stride length coeffici variat conclus hypokinet gait disord nph quantit differenti gait pattern elder popul futur studi approach may use differenti clinic entiti similar gait disord util instrument gait analysi procedur
|
D006850;D020233
|
T033;T184;T047
|
36,316,419
|
corneal langerhan cell children celiac diseas celiac diseas ced common small bowel enteropathi character alter adapt immun system increas mucos antigen present cell studi aim establish quantif corneal langerhan cell lcs use corneal confoc microscopi ccm could act surrog marker antigen present cell status henc diseas activ children ced twenti children stabl ced age match control underw ccm quantif central corneal total matur immatur lc densiti differ age vs p height vs p bmi vs p ohd level vs p signific lower children ced compar control total vs p immatur vs p matur vs p lc densiti differ ced control group howev immatur r p matur r p total r p lc densiti correl age immatur r p total r p lc densiti also correl tissu transglutaminas antibodi anti ttg level assess subject ced differ corneal lc densiti children ced control howev correl corneal lc densiti anti ttg level suggest relationship diseas activ ced requir studi
|
D002446
|
T047
|
36,316,418
|
milp base optim day ahead schedul system centric communiti energi manag system support differ type home energi trade optim day ahead schedul system centric communiti energi manag system cem propos provid econom benefit user comfort energi manag communiti level propos communiti includ differ type home allow prosum trade energi local use mid market rate mmr price mathemat model communiti construct optim problem model transform milp problem solv short time solv milp problem optim overal energi cost communiti satisfact thermal comfort everi home achiev comparison also establish two differ cemss communiti prosum centric cem cem simul result demonstr communiti propos cem lowest daili energi cost among three cemss particular communiti propos cem formula see text daili energi cost communiti prosum centric cem moreov use linear transform comput time optim problem propos system centric cem home communiti short time day ahead schedul communiti final investig trade mmr price local energi trade communiti allow profit differ type home flexibl adjust
|
D008962
|
T062;T170
|
36,316,417
|
role conflict process mechan decept respons consider number studi describ potenti neural mechan decept decept studi reli upon decept experiment supervisor instruct experiment control particip follow instruct deceiv without risk mean decept occur way come close real decept current studi neural imag experi decept closer real decept conduct event relat potenti erp event relat spectral perturb ersp techniqu use explor neural mechan decept result show decept respons evok larger medial frontal negat mfn smaller respons lock posit rlp truth respons interpret find indic conflict detect emot process associ decept addit magnitud alpha beta oscil decept respons signific smaller truth respons demonstr decept associ neural oscil reflect conflict adjust result comprehens character physiolog properti brain oscil elicit decept respons provid theoret foundat detect practic applic
|
D008192;D005071
|
T055;T042
|
36,316,411
|
intak digest rumin paramet perform lamb fed increas level red propoli extract object studi examin effect increas level red propoli extract rpe intak digest feed behavior rumen paramet metabol paramet perform feedlot lamb thirti five uncastr male santa in lamb initi weight kg use complet random design five treatment ml rpeanimalday anim confin day red propoli extract induc negat quadrat respons p intak dri matter organ matter crude protein ether extract neutral deterg fiber non fibrous carbohydr metaboliz energi appar digest coeffici dri matter organ matter neutral deterg fiber well rumen concentr nh n also respond quadrat p rpe feed effici increas linear p inclus rpe wherea rumin effici maximum p rpe level mlday red propoli extract induc linear respons p serum total protein albumin creatinin gamma glutamyl transpeptidas quadrat effect final bodi weight averag daili gain minimum valu inclus rpe mlday mlday respect feed effici rose linear p increas concentr rpe diet inclus ml rpeday mg total flavonoidsml diet feedlot lamb recommend reduc rumen nh n product increas anim perform
|
D012417;D011429
|
T123;T023;T121
|
36,316,405
|
predict drug target interact multi task learn identifi bind target protein molecul essenti drug discoveri multi task learn method introduc facilit knowledg share among task amount inform task small howev multi task learn sometim worsen overal perform generat trade individu task perform studi propos general multi task learn scheme increas averag perform also minim individu perform degrad group select knowledg distil group select basi chemic similar ligand set target similar target group train togeth train appli knowledg distil teacher anneal multi task learn model guid predict singl task learn model method result higher averag perform singl task learn classic multi task learn analysi reveal multi task learn particular effect low perform task knowledg distil help model avoid degrad individu task perform multi task learn
|
D000069550;D007858
|
T062;T041;T066;T061
|
36,316,404
|
synergist cellulos base nanocomposit packag cold plasma decontamin extend saffron preserv steril saffron packag maintain qualiti saffron content main prioriti saffron preserv common modal offer last saffron preserv urgent develop novel packag approach renew resourc prevent packag wast simultan decontamin qualiti mainten saffron demonstr first time synergist applic nano clay load carboxymethyl cellulos cmc polyvinyl alcohol pva nanocomposit cncs cold plasma cp compar separ use cp cmcpvanano clay result confirm synergi cp cmcpvanano clay caus complet inactiv escherichia coli bacteria signific affect concentr essenti saffron compon safran crocin picrocrocin overal cp treat cmcpvanano clay foster saffron preserv contamin remov qualiti mainten food product synergist applic cp cmcpvanano clay thus repres promis strategi packag steril preserv high valu food product
|
D027622;D058626;D053761
|
T104;T073;T002
|
36,316,402
|
catalyt nanozym zncl dope carbon quantum dot ratiometr fluoresc probe sequenti detect riboflavin cu thiamin novel metal dope zncl carbon quantum dot zncl cqds develop success ratiometr fluoresc probe sequenti detect riboflavin cu ion thiamin excel catalyt perform zncl cqds nanozym serv ideal platform sensit detect thiamin due addit riboflavin zncl cqds blue emiss peak zncl cqds nm remain unaffect use intern refer approach green emiss peak riboflavin nm appear increas remark follow presenc cu quench blue fluoresc signal zncl cqds observ result consequ fluoresc turn respons toward cu ion final upon addit thiamin solut alkalin condit blue emiss zncl cqds gradual recov prepar zncl cqds could act nanozym catalyst direct catalyz oxid non fluoresc substrat thiamin produc high fluoresc substrat thiochrom result blue fluoresc emiss peak nm recov eventu sequenti detect properti ratiometr probe riboflavin cu ion thiamin success appli vb tablet drink water vb tablet good recoveri respect
|
D045663
|
T073
|
36,316,398
|
grassland coverag chang human effect factor quantit assess zhejiang provinc china studi aim make clear grassland coverag chang quantit assess effect factor collect data nation bureau statist http wwwstatsgovcn china th centuri land usecov chang lucc spatio tempor platform grassland coverag area show upward trend grassland coverag area gradual decreas grassland coverag area chang much medium coverag grassland area highest correl total popul high coverag grassland area lowest correl total popul land use type composit gross agricultur output influenc grassland coverag area hope relev polici consid land use type ecolog benefit balanc econom develop urban develop
|
D003247;D065948
|
T078;T082;T069;T081;T064
|
36,316,394
|
predict textil pill resist use optic coher tomographi paper describ new method textil pill predict base multivari analysi spatial layer surfac origin idea method acquisit fabric imag use optic coher tomographi oct infrar light allow fabric fuzz visual high sensit pill layer reconstruct resolut formula see text includ reliabl textur inform relat amount loos fiber bunch appear result abras pill intens assign supervis classif textur featur use linear pls da partial least squar discrimin analysi lda linear discrimin analysi non linear svm support vector machin classifi result demonstr method suitabl fabric short term abras fuzz prevail tangl fiber pill layer case pill grade predict formula see text accuraci sensit specif svm model valid accuraci test model machin abras achiev lower valu formula see text lda model method clear show oct use quantit trace appear chang fabric sampl due test abras
|
D041623;D060388
|
T060;T081;T066
|
36,316,387
|
artifici intellig use diagnos osteoporosi risk factor clinic data propos sport protocol osteoporosi op character diminish bone mass deterior bone structur increas chanc fractur spine hip wrist paper novel data process method artifici intellig ai use evalu predict classifi op risk factor clinic data men women separ addit artifici intellig use suggest appropri sport program treatment data obtain dual energi x ray absorpt scan center ayatollah kashani milad khatam al anbia hospit tehran iran subject includ men women model develop use decis tree random forest rf k nearest neighbor support vector machin gradient boost gb extra tree ada boost ab artifici neural network multilay perceptron analysi predict osteoporosi recommend sport program data divid train test dataset result obtain test dataset area receiv oper characterist curv auroc use compar perform model predict healthi individu osteopenia osteoporosi fr algorithm auroc perform best men gb algorithm auroc perform best women compar classif algorithm predict rf algorithm women men auroc respect show highest perform diagnos type exercis healthi individu osteopenia op eight ai algorithm develop compar accur predict osteoporosi risk factor classifi individu three categori healthi osteopenia op addit ai algorithm develop recommend appropri sport program part treatment appli ai algorithm clinic set could help primari care provid classifi patient osteoporosi improv treatment recommend appropri exercis program
|
D010024;D001851
|
T047
|
36,316,386
|
binocular function patient intermitt exotropia accompani unilater congenit ptosi patient intermitt exotropia ixt wide rang binocular deficit studi aim evalu effect ptosi binocular function patient ixt clinic record ixt patient congenit ptosi ixt ptosi group age match ixt patient without ptosi ixt group present eye examin januari june retrospect review patient amblyopia exclud rule effect visual acuiti binocular best correct visual acuiti bcva magnitud exodevi distanc near stereopsi offic base control score first visit review binocular function two group compar mean sd age overal patient year signific differ distribut age sex spheric equival refract bcva two group p although offic base control score distanc near slight wors ixt ptosi group differ statist signific distanc vs p near vs p furthermor ixt ptosi group wors stereopsi distanc p signific differ two group near stereopsi exodevi magnitud p larger proport patient suppress bagolini test ixt ptosi group ixt group p ixt ptosi group wors distanc stereoacu larger proport patient suppress bagolini test ixt group ixt patient presenc coexist ptosi deleteri impact binocular function
|
D005099;D001763
|
T047
|
36,316,384
|
transversus abdomini releas tar procedur retrospect analysi abdomin wall reconstruct group complex abdomin wall defect import condit high morbid lead impair patient physic condit qualiti life last decad abdomin wall reconstruct paradigm chang due format experienc excel group improv clinic outcom surgeri therefor studi show perspect outcom abdomin wall reconstruct group awrg colombia focus transvers abdomini releas tar procedur retrospect review prospect collect databas conduct patient older year old underw tar procedur januari decemb includ analysi descript postop outcom recurr surgic site infect ssi seroma hematoma intervent perform patient underw tar procedur patient male mean age year mean bmi kgm abdomin wall defect classifi eh ventral hernia classif w hernia defect mean gap size cm cm mean cedar preoper risk score preoper use botox therapi p ci pneumoperitoneum p ci slight associ postop hematoma term hernia relaps case year surgeri tar procedur complex abdomin wall defect specif clinic condit includ emerg scenario viabl special experienc group show better postop outcom studi need confirm result
|
D034861;D006555
|
T023;T190
|
36,316,382
|
elucid gut microbiom alter tribal communiti arunach pradesh perspect lifestyl food habit gut microbiota studi ethnic popul reveal gut microbi biomark therapeut option detect diseas state present studi aim analyz gut microbiom signatur thirti individu adi apatani nyshi tribe arunach pradesh ten cohort sequenc v v region rrna illumina miseq platform gut microbiom high predomin firmicut actinobacteria proteobacteria bacteroid three studi tribal group genus level signific abund bifidobacterium collinsella bacteroid prevotella lactobacillus streptococcus clostridium coprococcus dorea lachnospira roseburia ruminococcus faecalibacterium catenibacterium eubacterium citrobact enterobact observ amongst three tribe tribal communiti resid remot area follow tradit lifestyl higher gut microbiom divers high preval prevotella collinsella adi nyshi tribe bifidobacterium catenibacterium apatani tribe elucid gut microbiom tribal communiti arunach pradesh add knowledg relationship microbi communiti dietari food factor overal state health human worldwid
|
D000069196
|
T007;T001
|
36,316,380
|
autom detect pattern singl cell within hydrogel use deep learn singl cell analysi wide use various biomed engin applic rang cancer diagnost immun respons monitor drug screen singl cell isol fundament observ singl cell activ automat find method accur reliabl cell detect possibl human error also essenti paper report trap singl cell photo pattern hydrogel microwel array isol addit present object detect base dl algorithm detect singl cell microwel array predict presenc cell resourc limit environ highest possibl map mean averag precis averag infer time algorithm lead enhanc high throughput singl cell analysi establish high detect precis reduc experiment time
|
D020100;D000077321
|
T122;T066
|
36,316,377
|
social evalu scientif occup scienc scientist among key driver societ progress technolog develop research demonstr scienc perceiv heterogen work percept scientist usual consid scientist member homogen group present research went beyond general categor investig differ social evalu differ type scientist across four studi conduct uk us total n discov member frequent mention scientif occup respect countri seen high compet relat moral moder sociabl also found individu perceiv differ scientif occup across social dimens captur cluster scientif occup chemist biologist physicist repres mention high prototyp scientif occup perceiv prototyp primarili associ compet rate mean public view scientist mean compet percept moral sociabl vari notabl across cluster overal demonstr focus scientist lead overgener distinguish differ type scientist provid much need nuanc pictur social evalu scientist across occup
|
D009790;D009014
|
T078;T090;T057
|
36,316,375
|
temperatur control laser thermal therapi system use newli develop laparoscop system equip ultra compact thermograph camera laser thermal therapi one treatment malign tumor develop thermal endoscop use ultra compact thermo sensor establish new laparoscop laser thermal therapi system heat cancer tissu appropri temperatur focus fact thermograph camera capabl two dimension temperatur map hepatocellular carcinoma ns cell implant liver spragu dawley rat n creat orthotop hepatocellular carcinoma six rat underw laparoscop laser thermotherapi c min use newli develop system other underw laparoscop insert lesion volum measur histolog evalu perform rat laparoscop laser thermal therapi system provid stabl temperatur control temperatur c use set temperatur temperatur target cancer maintain within rang c irradi time min median volum tumor thermal treat signific smaller untreat tumor newli develop laparoscop laser thermal therapi system capabl maintain temperatur tumor surfac desir temperatur proven effect treatment rat hepatocellular carcinoma model
|
D006528;D053685;D010535;D008113
|
T061;T060;T191;T074
|
36,316,374
|
honey composit converg parallel domest social bee honey collect evolv simpl honey hunt parallel independ domest differ speci bee various part world studi investig extent composit api stingless bee honey driver select differ bee speci domest mesoamerica mexico asia thailand use sampl design combin peak honey profil h nmr spectroscopi collect honey domest undomest bee speci result show independ region world consid domest stingless bee produc honey whose composit profil differ non domest speci exhibit similar toward honey produc domest api speci result provid evid first time search natur sweeten environ ancestor led parallel independ domest social bee produc honey similar composit profil
|
D006722
|
T168
|
36,316,373
|
fabric biodegrad chicken feather ecofriend function biomateri character bio assess studi studi aim investig novel applic chicken feather wast hydrolys green sustain process accord enzymat degrad chicken feather edcf product use dual carbon nitrogen sourc product medium bacteri cellulos bc yield maxim attain appli experiment design optim level signific variabl record yield rose time produc bc success character ft ir xrd sem hand sludg edcf use paper coat agent mechan featur coat paper evalu bulk densiti maximum load break length tensil index young modulus work break coat layer result show decreas tensil index increas elong break indic flexibl coat paper coat paper exhibit higher resist water vapor permeabl remark oil resist compar uncoat one furthermor effect sludg residu remov heavi metal evalu sorption capac order cu fe cr co high affin mgg toward cu low mgg toward co test metal solut
|
D005241;D019216
|
T023;T196
|
36,316,372
|
comprehens singl shot biophys cytometri use simultan quantit phase imag brillouin spectroscopi singl cell analysi cytometri ubiquit tool biomed scienc wherea cytomet use fluoresc probe ascertain presenc absenc target molecul biophys paramet cell densiti refract index viscos difficult obtain work combin two complementari techniqu quantit phase imag brillouin spectroscopi label free imag cytometri platform capabl measur dozen biophys properti individu cell simultan use geometr simplif link fresh plate cell acquir cellular diamet volum refract index mass densiti non aqueous mass fluid volum dri volum fraction water content cell mass volum brillouin shift brillouin linewidth longitudin modulus longitudin viscos loss modulus loss tangent singl acquisit assumpt under paramet method valid across three cell popul includ control popul cho k cell cell expos tubulin disrupt nocodazol cell hypoosmot shock system unlock new avenu research biophys cell biolog medicin
|
D059010;D003952
|
T060;T059
|
36,316,371
|
deoxygen lower thermal threshold coral bleach exposur deoxygen climat warm pollut emerg contribut factor coral bleach mortal howev combin effect heat deoxygen bleach suscept remain unknown employ short term thermal stress assay show deoxygen seawat lower thermal limit acropora coral much c c base bleach index score dark acclim photosynthet effici respect use rna seq show similar stress respons heat without deoxygen seawat activ putat key gene hypoxia induc factor respons system indic cellular hypoxia also detect distinct deoxygen respons includ disrupt depend photo recept protect redox status activ immun respons prior onset bleach thus coral even vulner face heat stress deoxygen water highlight need integr dissolv measur global monitor program coral reef
|
D000088982;D037421
|
T204;T067
|
36,316,365
|
ezh regul oncomir c emt marker esophag squamous cell carcinoma ezh histon methyltransferas associ cancer develop metastasi possibl regul microrna cellular pathway emt studi effect ezh express mir c import gene emt pathway investig esophag squamous cell carcinoma escc compar qrt pcr use examin ezh express escc line ym kyse follow separ transfect silenc ectop expression ezh vector escc subsequ express mir c emt marker also assess use qrt pcr western blot immunocytochemistri underexpress mirc detect ym kyse cell ezh silenc overexpress observ ezh induc express follow ezh silenc downregul mesenchym marker upregul epitheli marker detect escc result demonstr ezh regul express mir c critic emt gene impli overexpress zeb fibronectin n cadherin vimentin lead mesenchym phenotyp morpholog underexpress epitheli gene enhanc cell migrat enforc express ezh escc ezh gene benefici treatment marker patient esophag cancer decreas invas diseas effici respons neoadjuv therapi
|
D000071221;D058750;D004938;D000077277;D035683
|
T123;T116;T191;T126;T114;T043
|
36,316,364
|
use glycom array establish anti carbohydr antibodi repertoir type diabet type diabet td autoimmun diseas character presenc autoantibodi protein non protein antigen report identif specif anti carbohydr antibodi aca associ pathogenesi progress td compar circulatori level aca glycan cross section cohort td patient n healthi control n well longitudin cohort n identifi cluster aca associ glycan function class cluster enrich aminoglycosid blood group b antigen glycolipid ganglio seri link glycan associ progress td aca gentamicin relat structur g sisomicin also associ islet autoimmun aca improv discrimin td status individu model clinic variabl potenti biomark td
|
D003922
|
T047
|
36,316,363
|
sila system scientif imag analysi great deal imag found scientif public retouch reus compos enhanc qualiti present instanc edit benign help reader better understand materi paper howev edit instanc scientif misconduct undermin integr present research determin legitimaci edit made scientif imag open problem current technolog perform satisfactorili fulli autom fashion thus remain human expert inspect imag part peer review process nonetheless imag analysi technolog promis becom help expert perform essenti yet arduous task therefor introduc sila system make imag analysi tool avail review editor principl way sila first human loop end end system start process articl pdf file perform imag manipul detect automat extract figur end imag proven graph express relationship imag question explain potenti problem assess efficaci introduc dataset scientif paper around globe contain annot imag manipul inadvert reus serv benchmark problem hand qualit quantit result system describ use dataset
|
D007091;D015871
|
T068;T066;T080
|
36,316,362
|
photo crosslink ligninpan electrospun separ safe lithium ion batteri novel crosslink electrospun nanofibr membran maleat lignin ml poli acrylonitril pan present separ lithium ion batteri lib alkali lignin treat esterif agent maleic anhydrid result substanti hydroxyl group convers enhanc reactiv mechan properti final nanofib membran maleat lignin ml subsequ mix uv curabl formul wt contain polyethylen glycol diacryl pegda hydrolyz trimethoxysilyl propyl methacryl hmemo crosslink poli acrylonitril pan precursor polym uv electrospin use fabric panmlhmemopegda pmhp crosslink membran pmhp membran made electrospun nanofib featur three dimension porous structur interconnect void fiber mechan strength pmhp membran thick enhanc variat cross linkabl formul cell assembl pmhp membran wt ml show maximum ionic conduct valu cm signific higher cell liquid electrolyt commerci celgard cm enhanc lib effici pmhp membran attribut high poros allow better electrolyt uptak demonstr higher ionic conduct result cell assembl lifepo cathod li metal anod pmhp membran high initi discharg specif capac mah g c exhibit outstand rate perform also effect limit format li dendrit h pmhp separ improv chemic physic properti includ poros thermal mechan electrochem characterist compar commerci one
|
D008094;D008031
|
T121;T196;T123;T109
|
36,316,360
|
role age sex multimorbid year chang preval limit adult year recent data suggest tempor trend declin function limit older adult whether trend extend period th decad life remain unclear examin chang preval limit activ instrument activ daili live adl iadl among adult year role age sex multimorbid also examin chang sever limit data drawn two nation repres survey n n item scale adl iadl categor first limit examin sever limit weight logist multinomi regress use estim preval limit differ survey extract everi year year preval adl declin age ci age ci declin pronounc men women p valu interact observ primarili multimorbid p valu interact adl limit declin age ci ci age ci ci adl limit substanti chang iadl limit data high incom countri univers health care show improv adl even th decad life despit increas multimorbid
|
D000076322;D000203
|
T078;T056;T080
|
36,316,358
|
first line antiretrovir treatment failur associ drug substitut sex among children ethiopia systemat review meta analysi antiretrovir treatment art signific decreas hiv relat morbid mortal among children despit issu drug resist subsequ treatment failur appear challeng differ studi conduct ethiopia regard preval first line art failur among children magnitud studi inconsist great variabl review aim estim pool preval first line art failur among children associ drug substitut sex children among first line art user ethiopia review conduct use publish unpublish studi septemb ethiopia medlin pubm hinari web scienc googl scholar africa journal onlin ajol open gray literatur onlin repositori articl search qualiti individu studi assess joanna brigg institut jbi critic apprais checklist statist analysi done stata softwar random effect model use heterogen assess use forest plot cochran q test squar statist public bias check use funnel plot egger begg statist test interpret made odd ratio respect confid interv heterogen rate begg egger public bias insignific p valu respect pool preval pediatr first line art failur ethiopia ci subgroup analysi show highest failur rate virolog femal children time risk first line art failur ci first line art failur among children ethiopia consider high femal increas likelihood face first line art failur attent given femal children
|
D057915;D015658
|
T058;T047
|
36,316,356
|
hypothermia heart rate variabl healthi newborn piglet model decreas heart rate variabl hrv may biomark brain injuri sever neonat hypox ischem encephalopathi therapeut hypothermia standard treatment therapeut hypothermia may influenc degre brain injuri hypothermia may also affect hrv per se obscur potenti associ hrv hypox ischem encephalopathi previous result conflict studi aim investig effect hypothermia hrv healthi anaesthetis newborn piglet six healthi newborn piglet anaesthetis three piglet first kept normotherm c h expos hypothermia c h three piglet first expos hypothermia h rewarm normothermia h temperatur ecg record continu hrv calcul ecg min epoch includ time domain frequenc domain variabl hrv variabl compar hypothermia normothermia assess hrv variabl higher hypothermia compar normothermia heart rate lower hypothermia compar normothermia hrv variabl correl heart rate hypothermia associ increas hrv could mediat bradycardia hypothermia
|
D020925;D007035;D007036;D001930
|
T033;T047;T037;T061
|
36,316,355
|
explor various role hypoxia gene osteosarcoma osteosarcoma primari malign tumor often metastas orthoped diseas although multi drug chemotherapi surgic treatment signific improv surviv prognosi patient osteosarcoma surviv rate still low due frequent metastas patient osteosarcoma depth explor relationship various influenc factor osteosarcoma import screen promis therapeut target studi use multivari cox regress analysi select hypoxia gene slca fbp patient osteosarcoma use express two gene divid patient osteosarcoma high risk low risk group first construct prognost model base patient risk valu compar surviv differ high express group low express group second high express group low express group compar differ tumor invas inflammatori gene express two group immun cell final ferroptosi relat gene differ high express group low express group screen correl gene analyz high risk group immun cell higher tumor invas macrophag immun cell lower invas includ mast cell rest regulatori cell treg monocyt final among gene relat ferroptosi found akrc akrc alox may relat hypoxia ferroptosi relat gene discov first time osteosarcoma among hypoxia gene fbp posit correl ferroptosi gene akrc alox hypoxia gene slca negat correl ferroptosi gene akrc akrc alox studi construct prognost model base hypoxia relat gene slca fbp patient osteosarcoma explor correl immun cell inflammatori marker ferroptosi relat gene indic slca fbp promis target osteosarcoma research
|
D001859;D012516
|
T191
|
36,316,354
|
high speed scan laser structur multi layer ecobioresorb materi advanc electron system physic transient form electron enabl uniqu class technolog rang biomed implant disappear process bioresorpt serv clinic need internet thing devic harmless dissolv environ follow relev period use develop sustain manufactur pathway base ultrafast puls laser ablat support high volum cost effect manipul divers collect organ inorgan materi design degrad hydrolysi enzymat activ pattern multi layer architectur high resolut accur overlay registr technolog oper pattern thin andor cut mode ultra thin ecobioresorb materi differ type semiconductor dielectr conductor flexibl substrat compon level demonstr span passiv activ devic includ diod field effect transistor pattern devic interconnect layout yield function system illustr exampl rang wireless implant monitor neural cardiac activ thermal probe microvascular flow multi electrod array biopotenti sens advanc creat import process option ecobioresorb materi associ electron system immedi applic across near type bioelectron studi
|
D020341;D004581
|
T090;T074
|
36,316,352
|
uropygi gland microbiota differ free live captiv songbird symbiot microb affect host behavior fit gut microbiota receiv studi less attent import microbi communiti like scent produc gland mammalian anal gland avian uropygi gland howev mount evid suggest microb inhabit scent produc gland play import role anim behavior contribut variat chemic signal free live captiv condit typic differ social environ food divers avail diseas exposur factor translat differ gut microbiota howev whether extrins factor captiv alter microbi communiti scent gland remain open question compar uropygi gland microbiota free live captiv song sparrow melospiza melodia test effect dietari manipul gland microbiota captiv bird predict uropygi gland microbiota signific differ free live captiv bird surpris microbi divers higher captiv free live bird found effect dietari treatment captiv bird microbiota identifi specif factor respons microbi differ among group determin whether chang symbiot microbiota alter behavior fit import next step field
|
D020308;D064307;D046109
|
T001;T032;T028;T012
|
36,316,351
|
network analysi reveal tumor suppressor lncrna gas act doubl edg sword respons dna damag gastric cancer lncrna gas act tumor suppressor downregul gastric cancer gc contrast ef import transcript factor tumor promot direct inhibit mir c express gc cell line furthermor correspond gc cell line lncrna gas direct target ef howev lncrna gas mir c remain studi conjunct gc present dynam boolean network classifi gene regul two non code rnas ncrnas gc first studi show lncrna gas posit regul mir c gc previous unknown molecular pathway coupl lncrnamirna compar network sever vivoin vitro experi obtain excel agreement reveal lncrna gas regul mir c target ef addit found lncrna gas independ p inhibit gc prolifer atmp mapk signal pathway accord result support ef engag target drug develop tumor growth aggress prolifer gc favor result achiev tumor suppressor lncrna gasmir c axi gc thus find unlock new avenu gc treatment respons dna damag ncrnas
|
D035683;D062085;D013274
|
T123;T191;T114
|
36,316,350
|
effect auxet shoe lumbar spine kinemat kinet gait drop vertic jump combin vivo model investig present studi examin effect auxet shoe biomechan spine compar barefoot convent shoe condit gait drop vertic jump dvj activ use combin vivo musculoskelet model approach motion forc plate data well electromyograph emg activ select trunk muscl individu collect forego activ dvj activ two main phase first land fl second land sl studi fl phase dvj notic altern observ auxet shoe use compar convent footwear condit smaller emg activ extensor muscl p smaller anterior posterior ap distanc center pressur ground reaction forc heel p general larger maxim hip knee ankl flexion angl p final smaller maxim l compress forc maxim extern moment respect p obtain wear auxet shoe result therefor indic use auxet shoe reduc load lumbar spine high demand activ vertic jump thus may decreas musculoskelet risk injuri activ
|
D012775;D008159
|
T023;T073
|
36,316,348
|
intermedi snowpack melt date guarante highest season grassland green pyrene mountain area phenolog product grassland close relat snow dynam howev influenc snow melt time grassland grow still need attent full understand particular high spatial resolut aim reduc knowledg gap work exploit resolut snow depth normal differ veget index observ acquir unman aerial vehicl sub alpin site pyrene two snow season ndvi snow depth distribut acquir ha despit snow dynam differ two season respons grassland green snow melt exhibit similar pattern ndvi tempor evolut area distinct melt date reveal sector melt date occur late april earli may optimum melt reach maximum veget product zone earlier later melt rare reach peak ndvi valu result obtain studi area suggest knowledg snow depth distribut need understand ndvi grassland dynam analysi reveal clear link spatial variabl snow durat divers rich grassland communiti within studi area
|
D065948;D012914
|
T070;T082
|
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