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34,690,045
epigenet prime neurodevelopment disord neurodevelopment disord ndds affect popul caus mutat gene affect epigenet code limit function understand epigenet modifi suggest associ ndds caus part deficit epigenet prime prepattern step alter genom prepar make cell compet signal cue provid evid high resolut epigenet transcriptom map studi demonstr failur adequ prime genom neural induct could lead impair termin differenti cell idea provid framework ndd pathogenesi treatment
D065886
T048
34,690,044
arteri hypertens clinic trial updat review aim summar discuss relev clinic trial epidemiolog diagnost treatment hypertens publish
D006973
T047
34,690,041
orthodont treatment skelet class iii malocclus sever root resorpt maxillari anterior teeth autotransplant use dimension print replica donor tooth case report describ success orthodont treatment year old girl skelet class iii malocclus sever root resorpt maxillari anterior teeth ectop erupt mesial inclin bilater maxillari canin caus sever root resorpt right central later incisor left later incisor teeth extract traction appli maxillari right left canin toward extract right central incisor left later incisor respect mandibular arch bilater first premolar extract crowd correct extract mandibular right first premolar transplant extract maxillari right later incisor prepar tooth transplant cone beam comput tomographi imag use fabric dimension print replica donor tooth crown shape maxillari anterior teeth correct patient achiev function occlus pleas esthet root resorpt neglig transplant tooth studi demonstr satisfactori treatment outcom effect dimension simul tooth transplant
D008310;D012391
T190;T033;T047;T078
34,690,040
understand technolog adopt orthodontist quantit studi digit scan treatment plan dimension imag print chang practic orthodont tool adopt hope treatment becom predict effici effect reduc advers outcom digit tool impact care knowledg nationwid adopt trend motiv incomplet
D009970;D000066792
T091;T097
34,690,039
minimum data set traumat brain injuri iran traumat brain injuri tbi one major public health concern worldwid develop tbi registri could facilit character tbi monitor qualiti care quantifi burden tbi collect compar standard epidemiolog clinic data howev nation standard tool data collect tbi registri develop iran yet studi aim develop nation minimum data set mds hospit base registri patient suffer tbi iran
D000070642
T037
34,690,037
drastic chang practic end life care covid pandem articl discuss drastic chang practic end life care covid pandem review ethic dilemma individu autonomi versus societ justic human benefic versus public health non malefic aros pandem due prolong high acut critic ill set high contag respiratori virus protect person equip shortag crisi standard care distribut scarc medic resourc chang interact treat clinician patient visitor lesson learn pandem respons direct inform impact appraoch futur pandem event
D000086382;D013727
T058;T047;T067
34,690,031
epidemiolog massiv transfus common intervent need definit massiv transfus mt recipi account small proport transfus patient account approxim blood product issu furthermor mt event pose organiz logist challeng health care provid laboratori transfus servic overal major mt event support major bleed surgic patient trauma gastrointestin hemorrhag clinic context bleed event occur number blood product requir patient age comorbid import predictor outcom short long term surviv data import inform blood servic clinician health care provid order improv care outcom patient major bleed standard accept definit mt definit base number blood compon administ within certain time period activ mt protocol type definit use implic clinic characterist mt recipi includ epidemiolog intervent studi order understand trend incid mt variat blood util patient outcom harmon research outcom standard univers accept definit mt urgent requir
D001803;D014947
T037;T061
34,690,029
potenti impact vegetarian diet oral mucosa preliminari cytopatholog studi actual mani individu opt vegetarian diet object studi evalu impact vegetarian diet oral epithelium cytopatholog
D014676;D009061
T033;T023;T061
34,690,026
effect subclin emot behavior problem metabol control adolesc type diabet role matern adolesc person trait person trait adolesc type diabet mellitus tdm mother may lead poor glycem control psychiatr comorbid howev yet known person trait adolesc tdm mother affect metabol control absenc develop psychiatr disord aim determin effect subclin emot behavior problem well matern person trait metabol control adolesc tdm
D004644
T041
34,690,024
polycycl aromat hydrocarbon regul pigment pathway induc dna damag respons keratinocyt process driven system immun urban pollut correl increas preval skin pigment disord howev physiolog process under associ unclear
D004260
T045
34,690,022
opioid analges persist pain acut pain emerg depart visit evid cohort suspect urolithiasi patient sever acut pain still common treat opioid analges unit state practic could prolong durat pain
D059787;D052878
T047;T184
34,690,021
bilater retin detach healthi year old woman moderna sar cov vaccin although uncommon retin detach medic urgent result perman vision loss untreat bilater retin detach healthi individu even rare addit case date retin detach associ either coronavirus diseas covid receiv moderna mrna sever acut respiratori syndrom coronavirus sar cov vaccin
D000086382;D012163
T047;T067
34,690,020
effect n filter facepiec respir dental health profession emphasi pulmonari function heart rate intrasubject comparison despit ubiquit use n filter facepiec respir n ffr publish literatur topic remain scarc especi relat dental profession studi assess impact n ffrs blood oxygen satur heart rate dental health profession perform procedur requir vari degre physic exert aerosol rich environ total particip consist men eight women age year recruit studi subject well vers wear person protect equip ppe clinic grade puls oximet use clamp place around fingertip earlob particip select n ffr base fit leakag data collect particip use surgic mask control data collect subject hour use signific differ oxygen satur spo heart rate two group hour wear respect mask healthi young individu wear n ffr extend period time clinic dental procedur reduc spo level increas heart rate compar standard surgic mask howev spo level remain within healthi rang heart rate within accept limit
D016273;D012134
T074;T073;T037
34,690,019
reliabl cephalometr landmark identif three dimension comput tomograph imag aim evalu reliabl three dimension cephalometr landmark identif imag propos improv protocol determin landmark comput tomograph ct imag landmark obtain one show artifact asymmetri maxillofaci structur boni defect select two orthodont practition identifi cephalometr landmark time one week interv distanc landmark measur basi three refer plane coron horizont sagitt ten mean sd measur examin calcul maximum minimum valu differ measur one measur confid interv interexamin differ three plane found upper right first molar point gonion left orbital porion lower right first molar foramen magnum gnathion nasion pogonion show interexamin differ two plane menton basion posterior nasal spine upper lower left first molar right mental foramen show interexamin differ one plane refer intraexamin differ poor repeat observ gonion orbital condylion porion reliabl landmark meet point sutur distinct structur converg plane landmark posit midlin distinct anatom structur mental foramen teeth use multiplanar view
D054893;D021621
T062;T073;T060
34,690,017
analysi maximum bite forc chew effici unilater temporomandibular joint ankylosi case treat buccal fat pad interposit arthroplasti limit knowledg masticatori function releas temporomandibular joint tmj ankylosi studi masticatori function evalu measur maximum voluntari bite forc mvbf chew effici unilater tmj ankylosi patient treat buccal fat pad bfp interposit arthroplasti eighteen subject year age includ studi group subject year age studi group b patient studi group complet minimum follow one year surgeri control group c year age n year age n consist age sex weight match normal subject mean mvbf measur occlud molar teeth strain gaug transduc chew effici measur two differ colour chew gum strip chew stroke compar normal subject studi group b could generat p p mvbf respect overal chew effici group group b p p respect compar normal subject studi shown bfp interposit arthroplasti effect restor masticatori function
D000844;D001732
T046;T169
34,690,016
multipl oral mucocel treat even primros oil report two case multipl mucocel minor salivari gland rare mouth typic minor salivari gland soft palat affect report two case respond entir follow system therapi even primros oil recurr report two year follow period even primros oil postul effect composit andor viscos minor salivari gland secret
D009078;D031665
T190;T002
34,690,015
retrospect analysi schwannoma oral maxillofaci region clinicopatholog characterist specif patholog ancient chang schwannoma benign tumour origin schwann cell nerv despit frequenc occurr head neck data relat clinicopatholog featur region limit studi review clinicopatholog characterist specif patholog ancient degen chang case oral maxillofaci region medic record review case treat tokyo medic dental univers hospit faculti dentistri frequent involv site tongu averag tumour size mm degen chang observ eight case tumour complet excis biopsi local excis recurr observ clinic follow statist analys reveal signific associ p ancient chang tumour size ancient chang appar diffus coeffici adc valu deriv diffus weight magnet reson imag mri analysi suggest schwannoma progress long period subsequ undergo secondari ancient chang patholog event cystic format haemorrhag associ ancient chang caus hypocellular lead high adc valu valu may indic ancient chang consid distinguish schwannoma lesion
D009442
T191
34,690,012
user prefer engag text messag support antihypertens medic adher find pilot studi evalu emerg depart base behavior intervent examin user prefer engag text messag deliv part emerg depart ed base intervent improv antihypertens medic adher
D060145
T052;T170;T066
34,690,010
clinic intervent bud applic probiot treatment prevent viral infect period viral infect remain utmost challeng front scientif communiti continu shift draft viral antigen peptid main driver develop antivir drug resist resurg diseas difficulti face develop effect vaccin undesir immunolog outcom foster develop altern therapeut approach combat viral infect biomimet natur viral particl compet invad host cell downregul express immun respons cell reviv complic strengthen innat immun place first foremost defens mechan restrict viral infiltr varieg probiot strain show antivir activ stimul macrophag dendrit cell secret inflamm respons mediat chemokin cytokin product antimicrobi peptid biosurfact modul antivir gen express alter proport function cd cd foxp regulatori cell treg etc appreci antivir activ health benefit howev select specif probiot strain diversifi microbiom interact molecular mechan probiot viabil sustain specif number probiot strain end shelf life stabil select formul materi identif valid key process paramet major challeng develop effect probiot therapi viral infect
D000069196;D064307;D019936;D014777
T007;T047;T001;T032;T028
34,690,009
relationship acut phase reactant disabl guillian barr syndrom covid pandem guillain barr syndrom gbs immun mediat diseas affect peripher nervous system may occur bacteri viral infect
D000086382
T047;T067
34,690,008
effect breast cancer subtyp symptom improv follow palliat radiotherapi bone metastas assess relationship breast cancer subtyp patient report outcom pro follow palliat radiotherapi bone metastas
D001859;D001943;D018787;D064726
T091;T191
34,690,007
telodiag telomer paramet help glioma rapid diagnosi liquid biopsi approach glioma tert promot mutat loss atrx atrx loss associ reactiv telomeras altern lengthen telomer alt respect ie two telomer mainten mechan tmm strang glioma report display neither alter
D001932;D005910
T191
34,690,006
phenotyp variat urban environ mechan implic past decad numer studi explor urbanis affect mean phenotyp popul remain unknown urbanis impact phenotyp variat key target select shape shape eco evolutionari process review suggest urbanis may often increas intraspecif phenotyp variat sever process conclus align result illustr analysi tit morpholog across european cityforest popul pair urban driven chang phenotyp variat immens implic urban popul communiti particular urbanis effect individu fit speci interact conserv call studi incorpor phenotyp variat urban eco evolutionari research alongsid advanc theori
D000073537;D014507
T033;T080;T083;T068
34,690,005
ecolog impact discard cigarett butt cigarett butt one litter item global present uniqu challeng ecosystem due ubiqu persist potenti harm studi examin toxic cigarett butt biota aquat terrestri habitat microb mice mani organ habitat test two third studi aquat organ lethal effect common research impact terrestri life lag behind cigarett butt affect growth behaviour reproduct output individu organ three habitat research wider effect biodivers ecosystem function lack summaris ecotoxicolog concern identifi import knowledg gap futur research
D017753;D062789
T082;T073;T109;T131;T070
34,690,004
coffe caffein consumpt risk kidney stone mendelian random studi coffe caffein consumpt associ lower risk kidney stone observ studi conduct mendelian random studi assess causal natur associ
D003069;D007669
T047;T168
34,690,002
risk factor develop diabet mellitus kidney transplant occurr diabet mellitus common kidney transplant posttranspl diabet mellitus ptdm enhanc cardiovascular risk risk kidney graft loss incid ptdm studi aim examin potenti risk factor determin occurr ptdm
D003920;D016030
T047;T061
34,690,001
longitudin assess electrolyt disord cohort chronic stabl kidney transplant recipi kidney transplant complic various electrolyt disturb variabl report preval incid multifactori pathogenesi aim studi retrospect longitudin assess serum electrolyt cohort stabl kidney transplant recipi ktrs possibl associ paramet includ graft function medic
D016030
T061
34,690,000
updat coronavirus vaccin guidelin transplant recipi coronavirus diseas covid vaccin util solid organ transplant need time revis updat guidelin formal expert apex technic committe member nation organ tissu transplant organ head transplant societi guidanc transplant communiti recommend personnel involv organ transplant vaccin earli possibl continu covid appropri behavior despit full cours vaccin specif guidelin recipi suggest complet full schedul transplant whenev clinic condit permit also suggest singl dose rather proceed unvaccin transplant case complet cours feasibl vaccin plan surgeri recommend gap least week last dose vaccin surgeri vaccin transplant suggest wait week transplant potenti live donor recommend complet vaccin schedul transplant howev feasibl suggest receiv least singl dose vaccin week donat suggest suitabl transplant patient wait list accept third dose vaccin one offer recommend organ deceas donor suspectedproven vaccin induc thrombot thrombocytopenia avoid justifi case emerg situat inform consent counsel
D000086382;D017934;D016377
T061;T047;T005;T067
34,689,999
determin test perform two contemporari screen test lynch syndrom endometri cancer clinic trial publish data perform immunohistochemistri ihc test mismatch repair mmr protein express detect lynch syndrom ls index case suggest high variabl perform system unknown moreov brief famili histori questionnair bfhq develop eiriksson colleagu canada demonstr sensit ls case identif thus interest us perform outsid origin set unknown determin perform test requir complet ls case identif test popul
D008487;D011795
T057;T098;T170;T081;T058;T033;T062
34,689,998
osmot control releas oral tablet technolog function insight recent year oral osmot tablet spark therapeut paradigm control releas dosag form due intrins insensit physiolog physicochem factor despit benefit design optim osmot technolog preclud various challeng limit includ manufactur complex lack understand function mechan inadequ optim desir bio perform paper systemat review develop osmot driven drug deliveri system strategi zero order releas profil emphasi swellabl core technolog discuss applic various type osmot tablet suitabl specif need factor drive technolog select final review challeng opportun futur perspect associ osmot tablet
D016503;D013672
T074;T090
34,689,997
bioprint fabric live microalg materi bioprint fabric live microalg materi impend technolog transform field microalg biotechnolog balasubramanian et al demonstr bioprint use algin hydrogel encapsul creat uniqu photosynthet activ microalg biomateri biodegrad regen eco friend
D062028;D058086
T204;T063
34,689,995
divers converg within peripher glia develop recent studi tasdemir yilmaz colleagu use singl cell rna sequenc reveal divers among peripher glia chang develop also identifi unifi genet profil share matur glia data highlight new tool pathway understand peripher glial develop function
D009457;D012583
T025
34,689,993
intervent boost enrol nurs doctor philosophi phd program nurs doctor philosophi phd enrol languish littl known phd enrol strategi may lessen nurs phd shortag
D004511;D005181;D000071252;D015399
T097;T065;T062
34,689,992
epidemiolog periop anaphylaxi unit state new insight learn gonzalez estrada colleagu report estim risk sever fatal periop anaphylaxi one procedur period slight higher report previous franc england sever predictor near fatal fatal reaction identifi increas age cancer congest cardiac failur
D000707
T047;T046
34,689,991
im precis trial descript term prospect intervent control redund context randomis trial therefor distract pragmat probabl reserv trial intent control littl except exposur term pilot reserv trial design priori regist pilot trial appropri pilot outcom pragmat real world insert excus poor trial design similar pilot append excus inadequ power
D016032;D012107;D009626
T096;T170;T169;T081;T062
34,689,989
age person famili histori independ associ venous thromboembol follow acut achill tendon ruptur primari aim determin independ patient injuri manag relat factor associ symptomat venous thromboembol vte follow acut achill tendon ruptur atr secondari aim suggest clinic vte risk assess tool patient acut atr
D000125;D011655;D013708;D054556
T047;T023;T037;T046
34,689,988
clinic characterist surgic treatment traumat lumbar spondylolisthesi seri patient explor clinic characterist short term efficaci posterior oper traumat lumbar spondylolisthesi
D013123;D013168
T047;T061
34,689,987
relationship creatin kinas liver enzym war wound rhabdomyolysi rhabdomyolysi frequent complic war wound complex pathophysiolog suggest affect kidney also organ liver aim studi evalu relationship creatin kinas ck liver enzym war wound rhabdomyolysi
D058186;D008107;D012206
T033;T047;T037;T046
34,689,986
efficaci safeti tranexam acid hip fractur surgeri dosag affect outcom meta analysi random control trial object studi assess efficaci safeti intraven txa administr elder patient undergo hip fractur surgeri focus effect various dosag
D000933;D006620;D014148
T121;T037;T109
34,689,985
effect transfer status trauma outcom low middl incom countri systemat review meta analysi injuri lead caus disabl death worldwid low middl incom countri lmic disproportion burden trauma prior studi shown transfer status direct transfer injuri scene referr hospit versus indirect transfer anoth facil referr hospit may affect patient outcom purpos studi evalu relationship transfer status trauma patient outcom lmic conduct systemat review meta analysi
D003906;D014947
T080;T037
34,689,982
transcrani doppler find popul clinic probabl revers cerebr vasoconstrict syndrom describ transcrani doppler tcd find popul clinic probabl rcvs exploratori object includ studi clinic characterist probabl rcvs patient without spasm detect tcd
D051270;D013345;D020301
T033;T047;T046
34,689,981
link headach cognit disord systemat review overal preval headach decreas age howev headach remain frequent age individu also affect disord cognit declin despit high frequenc condit person associ headach cognit declin underexplor underdiagnos poor understood
D000544;D003072;D060825
T048;T047
34,689,980
futur hospit qualiti care polici multi stakehold discret choic experi flander belgium collabor policymak patient healthcar worker hospit qualiti care polici set improv integr new initi aim studi quantifi prefer various characterist futur qualiti polici broad group stakehold
D002755;D006761
T093;T073;T055
34,689,978
resid self assess common endocrin procedur general surgeri resid graduat expect profici straightforward endocrin oper studi aim elucid resid self assess abil perform common endocrin procedur
D013507;D013502;D007396
T091;T065;T097;T061
34,689,977
nasa tlx assess workload resid physician faculti surgeon cover trauma surgic intens care unit emerg general surgeri servic higher workload associ burnout lower perform therefor aim assess shift relat factor associ higher workload eg icu trauma surgeri servic
D016526
T081
34,689,975
transfus medicin informat review current practic glimps futur clinic informat describ relentless pursuit assist peopl use data inform technolog improv health care core principl person support inform technolog superior either person machin alon strive toward harmon transfus medicin field signific number accomplish clinic informat intervent help achiev better qualiti effici safeti near aspect transfus medicin review summar accomplish provid preview novel idea could transform transfus medicin proactiv data driven patient center disciplin
D008490;D064826
T091;T066
34,689,974
updat transfus medicin educ despit high frequenc blood transfus perform transfus medicin educ remain variabl unit state around world educ medic student nonpatholog physician critic safe evid base transfus mani innov curricula publish meet need physician train varieti specialti learner knowledg assess use valid knowledg assess tool object structur clinic examin review transfus medicin curricula assess tool review strategi virtual teach learn also introduc
D010820;D064826
T097;T091
34,689,973
transfus reaction advers event blood transfus general safe carri consider risk review summar differ type transfus reaction way diagnos manag symptom often overlap nonspecif reaction suspect critic stop transfus immedi report reaction blood bank affect patient outcom new evid base algorithm transfus newer blood screen method donor polici deferr new laboratori test electron verif system improv hemovigil lead avoid unnecessari transfus decreas incid serious transfus reaction
D065227
T047;T046
34,689,972
whole blood transfus past present futur transfus whole blood larg replac compon therapi recent militari oper iraq afghanistan return whole blood militari trauma care eventu whole blood use incorpor civilian trauma care util sever civilian popul well trial compar whole blood compon therapi ongo
D001803;D014947
T037;T061
34,689,971
granulocyt transfus clinic updat practic approach transfus neutrophil integr compon innat immun system key regul cell mediat defens bacteri fungal pathogen potenti granulocyt transfus investig temporarili replenish innat immun function prevent andor treat infect patient sever neutropenia neutrophil dysfunct howev evid larg theoret experiment andor inconclus clinic efficaci yet confirm larg scale random control clinic trial perform trial hamper low granulocyt collect yield poor patient accrual provid practic summari current literatur surround practic granulocyt transfus
D017708;D009503
T047;T061
34,689,970
concis synopsi current literatur guidelin practic plasma transfus evid base indic plasma transfus limit much clinic practic reli expert opinion articl highlight key studi meta analys guidelin plasma transfus adult goal limit non evid base plasma transfus outsid clinic guidelin transfus administr plasma without risk intend potenti benefit must apprais real risk associ transfus move forward practic plasma transfus would benefit great random control trial updat expand exist guidelin
D016913;D010949
T031;T061
34,689,969
platelet transfus updat indic guidelin platelet common transfus either therapeut prophylact maintain hemostasi platelet transfus use manag patient hematolog malign although platelet transfus guidelin publish platelet transfus practic still heterogen platelet transfus guidelin part lack recommend differ platelet threshold recommend clinic situat articl review platelet transfus focus transfus guidelin platelet threshold differ clinic set
D006470;D017713
T046;T061
34,689,968
red blood cell transfus red blood cell rbc transfus necessari increas patient oxygen carri capac optim transfus trigger remain elus restrict transfus trigger gdl shown studi reduc rbc transfus without advers affect patient outcom patient blood manag program shown effect reduc rbc transfus hemoglobin base oxygen carrier induc pluripot stem cell deriv rbcs develop help mitig rbc shortag rbc transfus limit numer challeng still exist need overcom widespread clinic use
D017707;D006454
T116;T061;T123
34,689,967
transfus blood bank recipi test pretransfus post transfus recipi test routin blood bank function articl present review request sampl requir routin extend type antibodi evalu post transfus circumst requir addit work although regiment approach blood bank fundament may view tedious step defin design prevent potenti fatal abo incompat transfus improv overal safeti transfus medicin patient
D001771;D001788
T058;T059;T093;T073
34,689,966
blood product donor noninfecti infecti test modif blood transfus begin safe donor select test unit state blood suppli transfus high regul blood transfus safeti multifacet wherebi element blood safeti valu chain span donor recruit qualif collect blood process test transfus practic posttransfus surveil must optim minim risk pathogen inactiv promis approach decreas bacteri contamin platelet inactiv parasit virus decreas risk associ emerg unidentifi pathogen articl offer overview blood donor infecti noninfecti test unit state
D058731;D003141
T047;T059;T061
34,689,965
donor screen deferr mainten adequ safe blood suppli begin choos right donor right time evolut donor screen shape experi donor satisfact ever challeng emerg relev infecti diseas screen donor standard past decad protect donor recipi safeti review outlin defin simplifi requir assess defer donor focus recent ongo chang provid date inform donor qualif current challeng maintain blood suppli
D001782;D046148
T058;T061;T098
34,689,960
peptid base therapeut emerg potenti therapeut agent covid sar cov posit sens rna virus causat agent global covid outbreak covid similar previous outbreak instanc sar mer peptid mani advantag peptid base therapeut might one possibl way develop covid specif drug sar cov enter human via protein attach human hace present cell membran lung intestin human hace cleav protein subunit viral attach subunit fusion host cell membran fusion mechan form six helic bundl hb structur final fuse viral envelop host cell membran hace base peptid sbp spikeplug shown potenti antivir agent protein hace interact sar cov fusion machineri play crucial part human viral infect evid interact could block success effici could way find drug covid sever peptid base inhibitor potent inhibitor protein hace interact similar antivir activ antimicrobi peptid lactoferrin make import candid covid drug develop process candid drug rhace apn base recombin hace peptid alreadi enter phase ii clinic trial review shed light differ aspect feasibl use peptid base therapeut promis therapeut rout covid
D000086382
T047;T067
34,689,959
applic benvitimod psoriasi systemat review meta analysi random control trial systemat review benvitimod psoriasi conduct systemat review clarifi efficaci safeti benvitimod psoriasi
D011565;D013267
T047;T109
34,689,958
survey opioid prescrib among dentist indic need effect educ regard pain manag dentist common prescrib opioid highest prescrib opioid patient year younger littl known dentist belief regard opioid analges
D000701;D059408
T131;T061;T121;T109
34,689,957
project influenc sugar sweeten beverag warn label restaur menu label regul energi intak weight status health care expenditur us adult microsimul accur readili access easi understand nutrit label promis polici strategi address poor diet qualiti prevent obes
D018673
T170
34,689,955
microbi divers format mainten due tempor nich differenti caus low dose ioniz radiat oligotroph environ planetari protect strive minim contamin microorgan spacecraft howev report microbi divers abnorm high intern space station iss long term exposur low dose ioniz radiat ldir remain mysteri ldir lead format mainten high microbi divers oligotroph environ like iss studi artifici microbi communiti cultiv without ldir respect microbi communiti compos three common microbi speci ie bacillus subtili escherichia coli pseudomona aeruginosa iss analyz differ microbi physiolog behavior respons characterist two scenario reason hypothesi propos elucid format mainten mechan high microbi divers oligotroph environ ldir set kinet model time lag develop base hypothesi observ phenomena experiment data final kinet model suffici valid hypothesi fulli confirm larg scale digit simul briefli decis success mechan oligotroph environ ldir tempor nich differenti tnd caus microbi delay respons ldir give rise asynchron converg fluctuat microbi popul signific allevi intra interspecif competit mechan drive microbi communiti oligotroph environ ldir form maintain high speci divers
D011839
T070
34,689,954
effect dietari aspirin high let radiat induc prostaglandin e level gastrointestin tumorigenesi apc n mice inevit exposur high let ioniz radiat ir present galact cosmic radiat gcr could enhanc gastrointestin gi cancer incid among astronaut undertak deep space explor gi cancer mortal predict far exceed nasa limit adjoin tumor analyz day post exposur aspirin led signific reduct pge dose depend manner reduc si induc gi tumorigenesi even highest mgday dose summari studi suggest aspirin could reduc high let ir induc pro inflammatori pge level howev lack abil reduc high let ir induc gi tumorigenesi apc n mice
D003359;D015232
T070;T121;T109;T125
34,689,953
lack mass transfer bone lacunar canalicular system may decis factor osteoporosi micrograv spaceflight astronaut experi bone loss per month especi lumbar spine pelvi lower limb bone loss lead osteoporosi increas risk fractur current research focus anti osteoporosi micrograv main inhibit bone resorpt osteoclast increas bone format osteoblast howev studi effect mass transfer bone lacunar canalicular system lcs osteoporosi lack osteocyt resid lacuna communic osteocyt osteoblast osteoclast lcs bone matrix osteocyt main respons mechanosens signal regul bone lcs basic structur signal mass transfer mechan stimul micrograv caus defici mass transfer lcs especi outer layer osteon osteocyt far away haversian canal inhibit acceler apoptosi stimul osteoclast result bone loss defici mass transfer lcs may determin human osteoporosi micrograv open new way treat osteoporosi space
D001862;D010024;D014893
T070;T047;T042
34,689,952
applic composit materi space radiat shield spacecraft energet ion beam experi major space radiat element h si fe conduct investig radiat shield properti composit materi materi expect use part fixtur space vehicl due mechan strength space radiat shield capabl low z materi contain hydrogen effect shield proton heavi ion due high stop power larg fragment cross section per unit mass stop power composit materi use work intermedi aluminum polyethylen typic structur shield materi use space total charg chang cross section per unit mass um composit materi time larger aluminum replac convent aluminum use spacecraft commerci avail composit carbon fiber polyeth ether keton expect shield effect increas util composit materi help mitig space radiat hazard futur deep space mission
D003359;D020450;D011835;D013026
T070;T061;T057;T196
34,689,951
propos chang astronaut exposur limit giant leap backward radiat protect address uncertainti assess health risk cosmic ray heavi ion major scientif challeng recogn mani previous report nation academi scienc nas nation council radiat protect measur ncrp advis nation aeronaut space administr nasa report suggest seri step pursu scientif basi space radiat protect includ implement age sex depend risk assess exposur limit appropri small popul radiat worker evalu uncertainti risk project develop vigor research program heavi ion radiobiolog reduc uncertainti discov effect countermeasur assess uncertainti assess risk provid protect chang assess risk reveal limit inform use space mission oper provid impetus reduc uncertainti discov true level risk possibl effect countermeasur research howev recommend recent nas report effort minim differ age sex flight opportun suggest msv career effect dose limit base median estim reach cancer fatal year old femal nas report call exampl femal would exclud space mission plan current decad use current radiat limit nasa addit minim consider level risk encount exposur level respect uncertainti heavi ion radiobiolog risk cancer well cognit detriment circulatori diseas furthermor recommend limit sievert risk conjunct waiver process essenti recommend remov radiat limit astronaut discuss issu sever nas recommend conclus recommend could negat impact crew health safeti violat three principl radiat protect prevent clinic signific determinist effect limit stochast effect practic alara would giant leap backward radiat protect
D003359;D011835;D013026
T070;T057;T061
34,689,950
gastrodia elata blume amelior circadian rhythm disord induc mice memori impair circadian rhythm disord crd space flight lead memori impair perform decrement advers health outcom main manifest circadian desynchron sleep loss insomnia sleep depriv sd provid mean evalu effect risk associ crd ground gastrodia elata blume geb benefici effect treatment sleep disturb memori loss fresh geb fg unprocess raw tuber geb use function health food asian countri long time howev research report fg amelior memori impair caus insomnia lack sleep meager studi icr male mice sleep depriv continu water extract fg wfg oral administr gkgd ig sd process last day except control model group gavag administr water posit control group modafinil mod gkgd ig studi effect wfg crd induc learn memori impair use set behavior analys includ object locat recognit test olrt novel object recognit test nort passiv avoid test pat addit oxid stress paramet assess measur malondialdehyd mda superoxid dismutas sod reactiv serum hippocampus result reveal sd decreas discrimin index di olrt nort shorter latenc dark chamber pat wfg mod treatment revers chang p conclud wfg treatment improv crd induc learn memori impair oxid stress damag make fg promis candid herbal health product memori declin crd
D021081;D031668
T048;T047;T002
34,689,949
mitig late cardiovascular effect oxygen ion radiat tocotrienol mous model concern degen tissu effect exposur space radiat deep space mission pharmacolog countermeasur advers effect tocotrienol gt natur form vitamin e anti oxid properti modifi cholesterol metabol anti inflammatori endotheli cell protect properti purpos studi test whether gt could mitig cardiovascular effect oxygen ion irradi mous model
D010100;D011837
T039;T121;T196;T123
34,689,948
baoyuan jieyu formula amelior depress like behaviour rat induc simul long term spaceflight composit stress regul mapk bdnf pathway space flight astronaut expos various influenc extrem environ suscept develop depress like behavior thus studi aim explor molecular biolog mechan caus depress like behavior reveal effect baoyuan jieyu formula byjyf amelior depress like behavior rat expos simul long term spaceflight composit stress lscs reduc sucros prefer rate p time forc swim immobl number climb time also reduc p p moreov number neuron ca region hippocampus decreas p p p stain becam weak nissl bodi decreas antibodi chip detect total protein molecul hippocampus protein signific differ lscs group lscsbyjyf group respect focus signal pathway mapk neurotrophin western blot use verifi relat protein two pathway conclus simul lscs induc depress like behavior neuron damag byjyf reduc neuron apoptosi promot neuron surviv regul mapk neurotrophin signal pathway protect neuron combat lscs
D003863;D013026
T048;T057;T184
34,689,947
spaceflight valid technolog point care monitor peripher blood wbc differenti astronaut space mission long durat orbit space mission astronaut experi immun system dysregul persist reactiv latent herpesvirus degre clinic incid plan nasa artemi deep space mission stressor caus phenomenon increas clinic care capabl like reduc current minim clinic laboratori capabl aboard intern space station iss abil monitor white blood cell count wbc differenti spaceflight unmet nasa medic requir primarili due lack capabl hardwar perform ground flight valid devic design monitor wbc differenti within minut fingerstick blood sampl devic miniatur robust general compat micrograv oper ground test spaceflight consist vibrat toler powerbatteri interfac requir electromagnet interfer emi basic evalu sampl prepar oper context spaceflight constraint flight valid perform aboard iss two astronaut includ assess three level control solut blood sampl well real time analysi fingerstick blood sampl one crewmemb flight ground test lot control solut yield similar total wbc valu select discrep flight ground data differenti analysi howev data suggest issu due compromis control solut result storag length flight oper due micrograv associ issu instrument perform evalu also yield lesson learn regard crewmemb train techniqu sensit small volum biosampl collect handl micrograv fingerstick analysi success first real time hematolog assess perform spaceflight devic may provid mission monitor capabl astronaut therebi assist flight surgeon crew medic offic orbit deep space mission
D013026;D014893
T070;T057
34,689,946
improv astronaut cancer risk assess space radiat ensembl model framework new approach nasa space radiat risk model success extend current nasa probabilist cancer risk model ensembl framework abl consid sub model paramet uncertainti well model form uncertainti associ differ theoret empir formal ensembl methodolog alreadi wide use weather predict model infecti diseas outbreak certain terrestri radiat protect applic better understand uncertainti may influenc risk decis make appli ensembl methodolog space radiat risk project offer potenti effici incorpor emerg research result allow incorpor futur model improv uncertainti quantif reduc impact subject bias moreov risk forecast across ensembl multipl predict model provid stakehold addit inform risk accept current healthmed standard met futur space explor mission human mission mar work ensembl risk project implement multipl sub model radiat qualiti dose dose rate effect factor excess risk latenc present initi consensus method ensembl model weight correl account individu model bias discuss analys ensembl forecast compar well result nasa current oper cancer risk project model use assess permiss mission durat astronaut howev larg rang project risk valu obtain upper th confid level model must extrapol beyond avail biolog data set closer agreement seen median one sigma due inher similar avail model identif potenti new model epidemiolog data method statist correl predict ensembl member discuss altern way communic risk accept uncertainti respect nasa current permiss exposur limit explor
D003359;D009369;D013026
T070;T191;T057
34,689,945
crew time workload eden iss greenhous antarctica goal eden iss project research technolog futur greenhous substanti part planetari surfac habitat paper investig crew time workload need oper space analogu eden iss greenhous site remot mission control center within almost three year oper antarctica differ veget crop cultiv yield edibl biomass kg experi phase oper remot environ analogu futur planetari mission greenhous system remot support capabl must care develop assess guarante reliabl effici workflow investig crew time workload crucial optim process within oper greenhous antarct winter season well summer season workload eden iss greenhous oper assess use nasa task load index addit crew time measur winter season particip consist site oper work insid eden iss greenhous antarctica dlr remot support team work mission control center dlr institut space system bremen germani crew time result show crew time whole experi phase requir site oper team approxim four time higher crew time correspond remot support team without consid plan activ next mission total crew time experi phase amount cm h cm hkg measur experi phase possibl develop methodolog crew time categor remot support activ facilit analysi increas compar crew time valu addit develop week month crew time demand experi phase present workload investig indic highest workload perceiv remot support team follow summer mainten team site oper team site oper team show lowest valu valu present paper indic need minim crew time well workload demand oper involv oper futur planetari surfac greenhous
D013026;D016526
T057;T081
34,689,944
design establish larg scale control ecolog life support system integr experiment platform control ecolog life support system celss meet demand food oxygen water human well provid psycholog benefit deep space explor continu materi regener mani key techniqu platform need explor appli extraterrestri planet studi larg scale celss integr experiment platform design construct meet basic life support materi demand six crew member max platform compos four kind cabin includ crew cabin cc plant cabin pc life support cabin lsc resourc recycl cabin rrc affili facil eight cabin involv platform ie ccs ii pcs ii iii iv lsc rrc platform involv subsystem cover plant cultur area max extens area total volum joint debug subject day celss integr experi carri success materi closur averag food high effici product period atmospher regener water regener recycl solid wast subject day integr experi verifi indic platform meet technic requir realiz food regener air regener water regener integr physico chemic techniqu biolog techniqu long term surviv six crew member close cabin
D018504;D013026;D018508
T052;T169;T057;T068
34,689,943
review research bioregen life support system support human live space travel beyond earth realiz long term surviv deep space human need construct bioregen life support system blss reduc requir suppli earth situ regener oxygen water food need astronaut prevent pollut extraterrestri bodi recycl wast sinc ussrrussia unit state europ japan china carri number studi abund achiev blss systemat theori plantsanimalsmicroorgan unit technolog designconstruct long term operationregul china lunar palac experi realiz earth base close human surviv year materi closur howev lot research work still need ultim realiz blss applic space especi given space experi blss never carri overal impact space environ blss unknown lunar explor project lunar villag lunar research station success proceed therefor futur blss research focus lunar probe payload carri experi studi mechan small uncrew close ecosystem space clarifi impact space environment condit ecosystem correct design oper paramet earth base blss research provid theoret technolog support blss applic crew deep space explor
D018504;D013026
T169;T057;T068
34,689,942
crew time space greenhous use data analog mission veggi crew time requir human space explor mission critic mass energi volum requir howev sporad record past analog space mission plant cultiv retrospect studi crew time data collect various analog facil veggi hardwar iss propos methodolog effici categor report crew time space plant growth system crew time difficult captur oper environ studi intend harmon effort among differ locat articl also provid current databas requir crew time sever plant growth hardwar facil iss earth data could serv mission planner baselin establish standard activ extrapol crew time need oper futur plant growth unit final discuss crew time need plant cultiv chang futur explor mission base choic made plant speci water system level autom use virtual assist among other crew time need account decis factor design futur space greenhous modul
D013026
T057
34,689,941
extens studi radiat dose human bodi aviat altitud mont carlo simul divers near earth radiat environ due cosmic ray solar radiat direct impact human civil present upcom era increas air transfer import precis idea radiat dose effect human bodi air travel calcul radiat dose human bodi aviat altitud also consid shield effect aircraft structur use mont carlo simul techniqu base geant toolkit consid proper mathemat model atmospher geomagnet field updat profil incom particl flux due cosmic ray appropri physic process use quasi realist comput phantom replic human bodi malefemal effect dose calcul develop simplifi mathemat model aircraft take boe lr refer shield studi simul radiat environ fli altitud km consid geomagnet latitud rang well various locat insid fuselag aircraft calcul dose rate differ organ male femal phantom base latest recommend intern commiss radio logic protect calcul show sex averag effect dose rate human phantom svh wherea calcul weight sum equival dose contribut separ femal male bodi total weight sum equival dose rate receiv femal phantom svh male phantom svh simul also calcul numer cosmogen radionuclid produc insid phantom activ spallat process may induc long term biolog effect
D001359;D003359;D016273;D011834
T089;T056;T037;T070;T059;T090
34,689,938
new advanc magnet reson imag diagnost imag techniqu evalu cranial nerv skull base skull base cranial nerv technic challeng evalu use magnet reson mr imag owe combin anatom complex artifact howev improv hardwar softwar sequenc develop seek address challeng section discuss cranial nerv imag particular attent techniqu applic limit mr neurographi diffus tensor imag tractographi advanc mr imag techniqu skull base patholog also discuss includ diffus weight imag perfus permeabl imag particular focus practic applic
D056324;D008279
T170;T059;T060
34,689,937
skull base neurointervent techniqu neurodiagnost neurointervent radiolog nir play central role diagnosi treatment skull base disord noninvas imag modal includ comput tomographi magnet reson imag import lesion local evalu lesion extent diagnosi alway definit imag guid skull base biopsi percutan endovascular treatment option import tool diagnosi treatment head neck skull base disord nir play import role treatment vascular disord skull base articl summar imag evalu intervent therapi pertin skull base
D008279;D019291
T170;T059;T060;T029
34,689,936
imag development skull base abnorm skull base critic structur craniofaci region support brain vital facial structur addit serv passageway import structur enter exit cranial caviti paper review highlight embryolog development anatomi includ ossif relat abnorm anterior central posterior skull base use illustr case tabl patholog dermoidsepidermoid cephalocel nasal glioma glioneuron heterotopia various notochord remnant persist craniopharyng canal teratoma platybasia basilar invagin clival anomali chiari malform discuss development pearl pitfal also highlight
D001139;D010985
T019
34,689,935
imag skull base trauma fractur pattern soft tissu injuri articl provid overview pattern skull base trauma provid review pertin soft tissu injuri complic ensu brief review skull base anatomi provid subsequ focus import find anterior central posterior skull base trauma
D006259;D017695
T037
34,689,934
imag acut chronic skull base infect skull base infect uncommon life threaten without time recognit imag play crucial role symptom vagu nonloc necrot otiti externa diabet immunocompromis patient commonest caus skull base osteomyel sbo follow sinogen infect idiopath central sbo multiparametr magnet reson mr high resolut ct mainstay establish diagnosi estim diseas extent mr superior ascertain marrow soft tissu involv monitor treatment respons imag fundament part challeng emerg promis imag tool
D010019;D010032
T047
34,689,933
imag anatomi patholog intracrani intratempor facial nerv facial nerv one complex cranial nerv motor sensori parasympathet fiber larg spectrum congenit inflammatori vascular neoplast process may affect one segment nerv custom use comput tomographi magnet reson imag combin good understand nerv anatomi relev clinicalsurg key point crucial appropri assess facial neuropathi articl review anatomi intracrani intratempor facial nerv imag featur frequent disord involv segment nerv
D020330;D005154
T023;T047
34,689,932
imag sella parasellar region sellar parasellar region complex uniqu mening neural vascular boni anatomi understand imag anatomi critic accur imag interpret reson mr imag primari modal pituitari imag wherea comput tomographi may use mr imag contraind provid complementari boni anatom inform articl review embryolog anatomi sellar parasellar region imag appear pituitari adenoma rathk cleft cyst meningioma craniopharyngioma arachnoid cyst vascular disord infecti abnorm pituitari apoplexi discuss illustr
D003397;D008577;D010911
T191
34,689,931
imag petrous apex lesion petrous apex may affect rang lesion common encount incident asymptomat find imag perform clinic reason symptom associ petrous apex lesion common relat mass effect andor direct involv close adjac structur petrous apex lesion optim assess use combin high resolut ct mri skull base manag petrous apex lesion vari wide reflect rang possibl patholog imag play key role includ lesion character surveil surgic plan oncolog contour
D008279;D010579
T023;T170;T059;T060
34,689,930
imag acquir skull base cerebrospin fluid leak acquir skull base cerebrospin fluid csf leak result trauma tumor iatrogen caus may spontan spontan skull base csf leak like manifest under idiopath intracrani hypertens initi assess rhinorrhea otorrhea suspect due acquir skull base csf leak requir integr clinic assess biochem confirm csf imag high resolut ct perform locat osseous defect high resolut tw mri may detect csf travers dura boni skull base leak multipl sampl fluid obtain test recours invas cisternographi may necessari
D002559
T047;T037
34,689,929
imag trigemin neuralgia facial pain review illustr radiolog facial pain emphas trigemin neuralgia relev anatomi current classif concept etiolog role imag influenc choic treatment discuss glossopharyng neuralgia neuropath caus facial pain postinflammatori neoplast caus nocicept end organ caus facial pain well refer otalgia condit may present facial pain includ trigemin autonom cephalgia giant cell arter review briefli discuss element comprehens mr imag protocol enabl detect divers caus facial pain
D020435;D014277
T047
34,689,928
pattern perineur skull base tumor extens extracrani tumor perineur extens increas recogn pathway extens cutan mucos salivari gland neoplasm associ sever advers prognosi imag identif feasibl mr imag dimension contrast enhanc submillimetr sequenc trigemin nerv branch facial nerv common involv pet comput tomographi may aid identif primari tumor locat recognit recurr conjunct mr imag achiev similar detect rate perineur extens comput tomographi scan adjunct mr imag increas specif surgic treatment plan
D003390;D006258;D019292
T191
34,689,927
imag vestibular schwannoma diagnosi monitor treatment plan appropri imag strategi detect treatment plan posttreat monitor vestibular schwannoma discuss typic variant imag appear vestibular schwannoma well imag featur prompt consider differenti diagnos illustr understand natur histori vestibular schwannoma optim measur definit tumour growth help radiologist evalu failur conserv manag requir surgeri radiotherapi order determin success conserv manag radiologist requir understand natur histori vestibular schwannoma tumour growth defin final imag featur help guid appropri treatment surgeri radiotherapi highlight expect posttreat imag chang describ
D009464
T191
34,689,926
anterior central skull base tumor key point radiologist analyz prior endoscop approach initi develop minim invas techniqu approach inflammatori condit transnas endoscop surgeri progress expand anatom target clinic indic consequ numer surgic approach anterior central skull base develop refer extend endonas approach eea intrins advantag eea exploit natur corridor provid sinonas airspac need skin incis osteotomi limit soft tissu damag context imag play essenti role demonstr relev anatom relationship lesion proper surgic corridor anatom variant may increas surgic risk
D019292
T191
34,689,925
neurosurg approach skull base guid radiologist skull base surgeri reli assess detail neuroimag studi assist surgic plan review typic neuroimag featur associ common neurosurg skull base approach highlight relev imag anatomi pertin postop imag appear
D019635;D019291
T029;T061
34,689,922
honey bee human euthanasia euthanasia anim cornerston veterinari medicin current offici criteria set euthanasia dispatch honey bee coloni mani method use around world vari regard techniqu materi volum agent use time method describ level effect safeti human although current common use methodolog may meet criteria human euthanasia veterinarian still appli profession standard key aspect act euthanasia
D037901;D018634
T058;T097
34,689,921
honey bee disast prepared respons articl review veterinarian assist apiarist client identifi hazard risk apiari veterinarian work client navig various phase disast plan respons well sourc inform biosecur diseas prevent summari insur program applic apiarist provid
D004189;D004190;D018634
T097;T052;T067;T064
34,689,920
foreign pest potenti threat north american apicultur tropilaelap mercedesa euvarroa spp vespa mandarinia vespa velutina honey bee face broad rang threat global mani threat origin outsid north america honey bee introduc speci invas pest among wide distribut damag econom cost honey bee hive associ intern trade travel continu rapid pace list invas apicultur pest like grow detail organ life histori relev manag erad effort address method propos method detect manag encount abroad discuss
D056630;D014863
T204;T090
34,689,919
practic applic genom manag honey bee health honey bee api mellifera model organ sociogenom one import manag pollin high mortal experienc honey bee coloni past sever decad expect substant effect crop pollin global food secur threat avail grow number genom resourc honey bee motiv research genet genom practic appli manag bee health author review applic certif bee lineag use singl polymorph marker breed bee use marker assist select diagnos honey bee stressor use biomark
D023281;D054817
T091;T040
34,689,918
honey bee api mellifera immun individu level honey bee api mellifera reli innat immun oper cellular humor mechan defend infecti agent parasit coloni level honey bee develop collect defens mechan pathogen pest hygien groom behavior understand immun respons honey bee critic implement strategi reduc mortal increas coloni product major compon mechan individu social immun honey bee discuss review
D007113
T032
34,689,917
honey bee nutrit optim nutrit crucial honey bee coloni growth robust immun system honey bee nutrit complex depend floral composit landscap forag behavior honey bee depend coloni environ extern environ signific gap knowledg regard honey bee nutrit henc optim diet avail honey bee livestock review discuss forag behavior honey bee nutrit need nutrit supplement use beekeep probiot supplement forag effort integr floral divers crop system
D004032;D009752
T033;T168
34,689,916
honeybe api mellifera health consider commerci beekeep addit challeng face honeybe coloni manag part commerci beekeep oper may subject addit stressor common beekeep outsid commerci set practic common commerci beekeep includ topic relat coloni transport manag larg apiari indoor winter handl ship packag bee queen bank queen discuss
D056630
T090
34,689,915
epidemiolog biosecur veterinarian work honey bee api mellifera honeybe veterinari medicin develop field canada unit state veterinarian interest work honeybe develop comprehens knowledg base diseas dynam appli individu coloni apiari broader honeybe popul current sever government academ industri organ carri epidemiolog base survey although honeybe face uniqu challeng regard biosecur basic principl still appli veterinarian use expertis area biosecur make improv current protocol within apiari beekeep oper
D018634
T097
34,689,914
work state provinci apiari program manag honey bee api mellifera health honey bee api mellifera health hive transport regul local apiari program compos apiari inspector inspector monitor ensur health honey bee field visit apiari inspect identifi diagnos provid recommend treatment honey bee health issu law regul pertain beekeep honey bee health present state territori provinc veterinarian encourag establish relationship local apiari inspector support beekeep manag healthi honey bee coloni
D056630
T090
34,689,913
regist medicin product use honey bee unit state canada us food drug administr mandat requir veterinari oversight medic import antibiot use agricultur anim includ honey bee api mellifera l creat new anim requir veterinari involv mani resourc avail describ medic formul antibiot drug use treatment various honey bee maladi goal articl summar inform date practic way clinician time write antibiot approv use honey bee requir veterinari prescript veterinari feed direct
D000900;D004364
T195;T121
34,689,912
honey bee diagnost honey bee face mani diseas serious other observ irregular routin hive inspect may indic potenti problem disord equal import detriment need immedi attent wherea other may need time clear import observ abl recogn diseas differenti correct treatment may done time manner need maintain health coloni coloni need healthi surviv prosper
D001516
T204