PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,668,692 | millipillar platform generat real time assess human engin cardiac tissu engin cardiac tissu deriv human induc pluripot stem cell ipsc increas use drug discoveri pharmacolog model develop diseas numer platform engin cardiac tissu often requir expens nonconvent equip util complex video process algorithm result special academ laboratori abl har technolog addit methodolog tissu featur challeng reproduc differ group model describ facil technolog millipillar cover entir pipelin requir studi engin cardiac tissu includ methodolog platform fabric ii cardiac tissu generat iii electr stimul iv autom real time data acquisit v advanc video analys valid methodolog demonstr versatil platform showcas fabric tissu differ hydrogel materi use cardiomyocyt deriv differ ipsc line combin differ type stromal cell also valid long term cultur tissu within platform provid protocol autom analysi forc generat calcium flux use brightfield fluoresc imag last demonstr compat millipillar platform electromechan stimul enhanc cardiac tissu function expect resourc provid valuabl user friend tool generat real time assess engin human cardiac tissu basic translat studi | D057026;D023822 | T025;T061 |
34,668,689 | reduct otorhinolaryngolog consult due covid lockdown impact diseas progress compar consult otorhinolaryngolog depart tertiari referr centr covid lockdown period well studi impact defer visit diseas progress | D000086382 | T047;T067 |
34,668,688 | open aneurysm repair patient concomit abdomin aortic aneurysm aorto iliac occlus diseas associ high mortal surgic complic rate evalu whether outcom open aneurysm repair combin aorto femor bypass patient concomit abdomin aortic aneurysm aaa aorto iliac occlus diseas aiod inferior open aneurysm repair isol aaa aorto femor bypass isol aiod | D017544;D001157 | T047 |
34,668,687 | low risk myocard pericard mrna covid vaccin discourag vaccin benefit vaccin regard covid infect transmiss well covid associ complic clear outweigh potenti risk vaccin associ inflamm heart advers event given current state knowledg outcom myocard pericard follow vaccin general good review aim guid physician earli diagnosi manag suspect myocard follow mrna covid vaccin initi work includ detail histori lead electrocardiogram serolog biomark high sensit cardiac troponin ti natriuret peptid marker inflamm accord assess recommend current clinic practic guidelin patient present acut chest pain patient suspect myocard assess transthorac echocardiographi cardiovascular magnet reson imag undertaken confirm peri myocard distinguish find diseas similar present patient mrna vaccin associ myocard follow least exclud chronic myocardi inflamm deterior left ventricular eject fraction consult expert immunologist experi vaccin regard mrna vaccin advis patient mrna vaccin associ perimyocard report mrna vaccin associ myocard swissmed mandatori cohort studi prospect follow young adult paediatr popul follow immunis mrna covid vaccin monitor cardiac immun paramet would generat valuabl knowledg better understand pathogenesi risk factor vaccin associ perimyocard | D000086382;D009205;D010493 | T047;T067 |
34,668,686 | cigarett afford canadian provinc year review associ price cigarett consumpt long establish howev effect taxat alon diminish relat incom increas therefor afford seen key determin demand cigarett combin impact chang price econom growth wage increas brief analysi employ method use world health organ examin cigarett afford explor trend afford across canadian provinc year period discuss illustr monitor afford time help polici maker canadian provinc design tobacco taxat maximum impact | D062789 | T131;T073;T109 |
34,668,685 | initi cessat keep preval smoke higher quebec rest canada compar smoke initi cessat quebec versus rest canada possibl underpin continu higher cigarett smoke preval quebec | D012907 | T055 |
34,668,684 | investig individu level correl e cigarett initi among larg sampl canadian high school student better understand individu factor associ e cigarett initi help improv prevent effort therefor studi aim identifi baselin characterist associ e cigarett initi determin whether chang baselin characterist associ e cigarett initi | D066300;D000072137 | T073;T055 |
34,668,681 | impact immun checkpoint inhibitor cost qualiti life initi treatment patient advanc metastat nsclc immun checkpoint inhibitor ici repres signific benefit initi treatment patient advanc metastat non small cell lung cancer nsclc beyond clinic benefit increas overal surviv repres class medic favor advers effect profil compar chemotherapi drug target program cell death protein pd receptor ligand pd l ici work take brake immun system promot cell mediat cancer cell destruct current nccn guidelin recommend patient advanc metastat nsclc pd l status amount pd l cancer cell assess guid treatment section howev recommend alway follow may lead inappropri treatment select potenti increas cost appropri biomark test subsequ appropri util ici may help drive cost improv health relat qualiti life manag care pharmacist continu focus promot guidelin concord care includ appropri biomark test select evid base prefer treatment option | D002289;D008175 | T191 |
34,668,680 | immunotherapi frontlin manag advanc metastat nsclc frontlin treatment paradigm patient advanc metastat non small cell lung cancer nsclc chang dramat past decad amid effort tackl lead caus cancer relat mortal immun checkpoint inhibitor ici target program cell death protein pd receptor ligand pd l import therapeut option patient whose tumor lack genet alter dictat respons molecular target therapi grow number fda approv ici monotherapi combin therapi option first line therapi use biomark pd l express becom increas import guid therapeut decis make present pd l express remain key biomark set spite limit articl evalu current evolv clinic trend use ici frontlin manag metastat nsclc well challeng associ pd l express analysi biomark implement | D002289;D008175 | T191 |
34,668,679 | impact advanc care plan consult advanc direct complet advanc care plan acp consult credit increas likelihood patient receiv desir care end life includ reduc hospit spend aim investig whether implement acp consult lead improv advanc direct ad complet rate | D032722 | T058 |
34,668,678 | comparison use top rank cancer hospit medicar advantag tradit medicar compar use top rank cancer hospit complex cancer surgeri medicar advantag tradit medicar fee servic ffs enrolle | D020398;D009369 | T033;T191;T089 |
34,668,677 | hypoglycemia upon hospit admiss long term care health care resourc use resid diabet long term care ltc set often recogn risk factor develop hypoglycemia includ advanc age dementia polypharmaci howev data regard hypoglycemia ltc associ hospit lack aim describ health care resourc use cost patient diabet hypoglycemia upon hospit admiss | D003924;D007003 | T047 |
34,668,676 | character patient flow academ hospit merger acquisit hospit merger acquisit increas use strategi facilit valu base care howev studi assess health care util hcu patient flow across merg institut aim evalu patient popul distribut hcu patient flow across recent hospit merger academ medic center amc primari specialti care allianc psc communiti base medic center cmc | D006273 | T058 |
34,668,675 | covishield india demystifi myth earli multicent studi nationwid covid vaccin initi india januari phase manner vaccin includ covishield vaccin indigen prepar serum institut india line oxford astrazeneca chadox vaccin develop univers oxford first multicent studi assess safeti indigen prepar covishield vaccin india | D000086382;D000086663 | T047;T200;T067 |
34,668,674 | reimburs genet variant reinterpret five question payer ask reach goal set health care payment learn action network requir unyield unrel focus encourag provid adopt advanc altern payment model apm mani model continu voluntari either earli stage yet proven effect model proven effect becom perman compris new way provid paid medicar program either way get today high perform program keep engag continu innov set new benchmark import attract improv perform poorer perform requir shift medicar polici price evalu apm | D006278;D012051 | T170;T089;T064 |
34,668,673 | agreement among measur examin low valu imag low back pain quantifi extent patient level agreement among publish measur low valu imag acut low back pain lbp | D017116 | T047;T184 |
34,668,672 | b drug price program hospit provis uncompens care evalu whether hospit entri b drug price program entitl elig hospit discount drug purchas intend hospit use associ save devot resourc care low incom popul associ chang hospit provis uncompens care | D010594;D017664 | T058;T093;T073 |
34,668,671 | medicar advantag pharmaci partnership improv influenza pneumococc vaccin rate evalu impact collabor effort medicar advantag prescript drug mapd plan communiti pharmaci improv vaccin rate pneumonia influenza | D003157;D007251;D020398;D010594;D010604 | T047;T089;T057;T073;T091;T093;T058;T033 |
34,668,670 | interest concern telehealth among adult age year describ associ patient factor interest concern telehealth video visit among adult midlif older | D017216 | T058 |
34,668,669 | patient support factor affect engag diabet telehealth assess patient famili support call characterist predict whether patient complet autom coach provid call telehealth diabet intervent | D003924;D017216 | T058;T047 |
34,668,668 | provid patient cancer access afford hous treatment patient travel cancer treatment often incur financi burden member allianc dedic cancer center play role mitig hous associ cost patient cancer treatment | D006798;D009369 | T191;T073 |
34,668,667 | tunabl hydrogel microchannel network studi confin mammalian cell migrat cell adapt move due chemic physic mechan cue microenviron therefor import creat materi mimic human tissu physiolog surfac chemistri architectur dimension control cell biomed set impact environment architectur particular relev context cancer cell metastasi cell migrat small constrict microenviron invad surround tissu synthet hydrogel scaffold interconnect random microchannel network present function collagen promot cell adhes shown cancer cell invad scaffold within day microarchitectur stiff hydrogel modul cell invas nuclear dynam cell specif found cell migrat microchannel function hydrogel stiff addit shown hydrogel stiff confin influenc occurr nuclear envelop ruptur cell tunabl hydrogel microarchitectur stiff thus provid novel tool investig cancer cell invas function microenviron furthermor materi provid promis strategi control cell posit migrat cellular function biolog applic tissu engin | D020100;D023822 | T122;T061 |
34,668,666 | character alzheim diseas like neuropatholog duchenn muscular dystrophi use dbaj mdx mous model duchenn muscular dystrophi dmd progress muscl wast disord caus mutat dystrophin gene addit muscl patholog patient dmd exhibit cognit impair sever link age type genet mutat likewis studi shown mdx mice display impair spatial memori compar wild type wt control other observ effect studi util tradit cbl c mdx mous exhibit mild diseas phenotyp recent dbaj mdx mous emerg sever perhap clinic relev dmd model howev studi examin cognit function mice limit thus studi examin cognit function age match c mdx mice along respect wt control find show week old c mdx mice display differ explor time challeng novel object recognit test convers age match mdx mice spent less time explor object total well less time explor novel object suggest impair recognit memori biochem analys mdx brain reveal higher solubl amyloid precursor protein app app prefront cortex mdx mice compar wt lower solubl app hippocampus suggest shift toward amyloidogenesi similar pathogenesi alzheim diseas furthermor studi demonstr util mdx model studi cognit impair | D000544;D020388 | T048;T047 |
34,668,664 | predictor empower parent children autism relat neurodevelopment disord undergo genet test limit empir data quantifi util genet test famili children autism spectrum disord asd relat neurodevelopment disord ndd assess util clinic chromosom microarray analysi cma defin diagnost yield parent empower popul base sampl parent affect children explor child famili health servic factor predict empower | D000079102 | T054 |
34,668,663 | muscl protein loss relev long term fast healthi men prospect trial physiolog adapt fast attract increas interest potenti strategi manag diseas includ metabol disord complementari cancer therapi despit concern clinician regard protein catabol muscl loss evid base clinic data respons long term fast healthi human scarc object studi measur clinic constant metabol muscular respons healthi men day fast combin physic activ programm | D000222;D005215 | T040;T033;T055 |
34,668,661 | haploident donor transplant associ secondari poor graft function allogen stem cell transplant singl center retrospect studi secondari poor graft function spgf serious complic allogen hematopoiet stem cell transplant allo hsct relat poor outcom aim retrospect evalu morbid hazard element spgf allo hsct | D018380 | T061 |
34,668,660 | progress free surviv assess per immun relat convent respons criteria better surrog endpoint overal surviv trial immun checkpoint inhibitor lung cancer systemat review meta analysi progress free surviv pfs use surrog endpoint overal surviv os lung cancer trial pattern respons immun checkpoint inhibitor ici differ convent chemotherapi immun relat respons evalu criteria propos studi aim determin pfs measur pfs assess per immun relat respons evalu criteria ipf convent criteria cpfs better surrog endpoint os trial ici lung cancer select clinic trial lung cancer administ ici least one arm report median os median pfs pubm embas cochran librari compar correl treatment effect hazard ratio os cpfs ipf correl median os median cpfs ipf use weight linear regress trial level analyz ici arm patient studi includ arm cpfs seven arm ipf five arm kind pfs demonstr excel correl treatment effect hazard ratio os ipf r wls correl moder cpfs r wls similar correl median os median ipf also strong r wls rang across differ phase trial differ type lung cancer ici treatment modal much weaker median cpfs r wls rang conclus ipf provid better trial level surrogaci os cpfs trial ici lung cancer | D015415 | T080;T201 |
34,668,659 | screen prototyp antiseizur anti inflammatori compound theiler murin encephalomyel virus model epilepsi infect theiler murin encephalomyel virus tmev cblj mice result handl induc seizur use evalu compound effect infect induc seizur howev date compound evalu model comprehens studi antiseizur medic asm yet perform furthermor tmev infect produc mark neuroinflamm evalu prototyp anti inflammatori compound need well | D004827;D017945 | T033;T047;T005 |
34,668,658 | communiti socioeconom depriv predict nonalcohol steatohepat order determin relationship socioeconom depriv nonalcohol fatti liver diseas nafld nonalcohol steatohepat nash retrospect review electron medic record patient larg tertiari health care network new york patient underw liver biopsi year period includ studi evid nafldnash liver biopsi zip code use obtain data necessari deriv social depriv index sdi us bureau census high sdi group compar low sdi group univari multivari logist regress perform assess associ socioeconom factor nafld paramet includ presenc nash nafld activ score moder sever steatosi signific fibrosi includ patient nafldnash median sdi hemoglobin ac valu higher high sdi group compar low sdi group vs p socioeconom factor privat versus public health care percentag foreign born percentag without car percentag higher need year old percentag current live renter occupi crowd hous unit show statist signific associ predict nash adjust patient age sex race bodi mass index diabet saw signific associ four socioeconom paramet predict nash odd ratio confid interv ci p six socioeconom paramet predict sever steatosi ci p signific correl number socioeconom paramet signific fibrosi conclus greater number socioeconom determin four associ greater sever nash awar nafldnash need rais communiti high socioeconom depriv | D065626 | T047 |
34,668,657 | influenc glycaem control macular thick diabet retinopathi diabet macular oedema dme one major caus decreas visual acuiti patient diabet retinopathi poor glycaem control associ increas incid dme | D003920;D003930 | T047 |
34,668,656 | pre process pipelin quantifi visual reduc technic variat protein microarray studi technic variat variat non biolog sourc present laboratori assay correct variat enabl analyst extract biolog signal inform question interest howev assay differ sourc level technic variat choic correct method impact downstream analys compar similar assay dna microarray relat method develop evalu protein microarray versatil tool measur level various protein serum sampl propos pre process pipelin correct common sourc technic variat protein microarray pipelin build upon exist normal method use control reduc technic variat evalu method use data two protein microarray studi simul demonstr pre process choic impact fluoresc intens base rank protein turn impact downstream analysi | D020869;D040081 | T059;T063;T075 |
34,668,655 | epidemiolog variant transthyretin amyloidosi refer center argentina argentina limit data preval variant transthyretin amyloidosi attrv phenotyp genotyp correl laboratori hospit italiano de bueno air hiba refer center transthyretin ttr gene sequenc institut amyloidosi registri ria enabl us character peopl attrv aim describ preval ttr mutat refer center argentina phenotyp present patient attrv includ institut registri | D010641 | T032 |
34,668,654 | theori base approach identifi nurs team member contribut electron health record team base care deliv interprofession team shown effect strategi care divers complex patient popul interprofession team improv outcom reduc cost enhanc patient experi patient center care nurs essenti member healthcar team within across set | D057286;D010348 | T058;T170;T073 |
34,668,652 | copi number variat analysi regul identifi mettl prognost immun relat biomark bladder cancer grow evid demonstr indispens role n methyladenosin human diseas copi number variat cnvs regulatori gene bladder cancer blca remain larg unknown | D056915 | T086;T045 |
34,668,650 | concuss long term cognit function among rugbi player brain studi brain studi establish assess associ self report concuss cognit function among retir rugbi player | D001265;D001924;D005538 | T056;T037 |
34,668,648 | hematopoiet pbx interact protein novel regul mammari epitheli cell differenti hematopoiet pbx interact protein hpip also known pbxip estrogen receptor er interact protein regul estrogen mediat breast cancer cell prolifer tumorigenesi howev function signific context mammari gland develop unexplor report hpip requir prolactin prl induc lactogen differenti vitro molecular analysi hpip express mice reveal induc express pregnanc lactat stage mammari gland moreov prl lactogen hormon control pregnanc well lactat induc hpippbxip express signal transduc activ transcript depend manner use mammari epitheli lactogen compet cell line show hpip play regulatori role prl mediat mammari epitheli cell differenti measur acini format casein synthesi lipid droplet format mechanist studi use pharmacolog inhibitor reveal hpip modul prl induc casein synthesi via phosphoinositid kinas pik protein kinas b akt activ studi also identifi hpip critic regul autocrin prl signal treatment prl receptor antagonist gr hprl restrain hpip mediat prl synthesi akt activ casein synthesi cultur hc cell interest also uncov microrna mir antagon hpip mediat mammari epitheli cell differenti togeth studi identifi hpip critic regul prl signal reveal novel molecular circuitri involv prl hpip pikakt mir control mammari epitheli cell differenti vitro | D035683;D051057 | T116;T126;T114;T123 |
34,668,646 | enhanc scienc literaci communic among next generat scientist onlin learn environ mani larg undergradu scienc cours still heavili reli tradit lectur base dissemin content passiv learn exam base assess forc onlin due covid pandem address challeng face student regard engag self direct learn develop soft skill modifi larg lectur base third year undergradu biochemistri cours univers toronto foster activ learn interact e modul also adjust evalu model focus develop reflect critic think scienc literaci communic | D003142;D000067010 | T097;T170;T033;T169;T054;T080 |
34,668,645 | differ mutat mmut gene associ effect vitamin b cohort chines patient mut type methylmalon acidemia retrospect studi summar relationship differ mmut gene mutat respons vitamin b mma | D014805 | T127;T121;T109;T114 |
34,668,644 | effect adher cognit multidomain lifestyl intervent finger lifestyl intervent may prevent cognit declin suffici dose intervent activ lifestyl chang unknown investig intervent adher affect cognit finger trial pre specifi subgroup analys | D003072;D060825 | T048 |
34,668,643 | diagnosi hypertens ambulatori pediatr american heart associationeuropean societi hypertens versus blood pressur load threshold agreement tradit use ambulatori blood pressur abp load threshold children recent recommend pediatr american heart associ aha european societi hypertens esh abp threshold diagnos ambulatori hypertens ah white coat hypertens wch mask hypertens mh evalu cross section studi outpati particip author evalu agreement previous use abp load threshold ahaesh threshold diagnos ah wch mh american academi pediatr threshold use diagnos offic hypertens aha threshold diagnos ambulatori normotensionhypertens closest abp load ci particip k ci esh threshold diagnos ambulatori normotensionhypertens closest abp load ci particip k ci contrast ahaesh threshold relat weaker agreement abp load therefor diagnosi ah closest aha threshold abp load differ ci p esh threshold abp load differ ci p ahaesh abp load threshold similar agreement pattern persist ahaesh various abp load threshold diagnos wch mh aha esh threshold diagnos ah wch mh closest abp load abp load futur outcom base studi need guid optim use abp threshold clinic practic | D006973;D059468;D010372;D059466 | T091;T033;T047 |
34,668,642 | plant reovirus hijack dnajb hsc chaperon complex promot viral spread planthopp vector mani virus usurp function endoplasm reticulum er virus encod membran protein proper function fold assembl promot virus spread southern rice black streak dwarf virus srbsdv plant reovirus exploit virus contain tubul compos nonstructur membran protein p spread planthopp vector sogatella furcifera report two factor er associ degrad erad machineri er chaperon dnajb cytosol co chaperon hsc activ srbsdv facilit er cytosol export p tubul furcifera p srbsdv hsc direct bind j domain dnajb dnajb overexpress induc er retent p hsc overexpress promot transport p er cytosol initi tubul assembl thus p initi retain er interact dnajb deliv hsc furthermor inhibitor atpas activ hsc reduc p tubul assembl suggest proper fold assembl p tubul depend atpas activ hsc dnajb hsc chaperon complex recruit p tubul virus infect midgut epitheli cell furcifera knockdown dnajb hsc strong inhibit p tubul assembl vivo final suppress effect viral spread furcifera taken togeth result indic dnajb hsc chaperon complex erad machineri facilit er cytosol transport p proper assembl tubul enabl viral spread insect vector manner depend atpas activ hsc | D006430;D012275 | T204;T002;T168 |
34,668,641 | effect anti attent deficit hyperact disord adhd medic clinic seizur sleep eeg retrospect studi japanes children adhd patient attent deficit hyperact disord adhd often exhibit basic paroxysm wave abnorm electroencephalographi eeg methylphenid mph anti adhd stimul report lower seizur threshold howev report compar eeg chang administr central nervous system cns stimul mph atomoxetin atx hydrochlorid non cns stimul studi investig chang sleep eeg administr adhd treatment drug | D001289 | T048 |
34,668,640 | outcom intravascular ultrasound versus optic coher tomographi guid percutan coronari angiographi meta regress base analysi studi compar clinic outcom intravascular ultrasound ivus versus optic coher tomographi oct guidanc percutan coronari intervent pci patient present coronari arteri diseas includ stabl angina acut coronari syndrom limit | D003324;D062645 | T047;T061 |
34,668,639 | effect method isol purif extracellular vesicl plant plant extracellular vesicl ev play critic role cross kingdom traffick molecul host interact microb notabl plant defens respons howev isol pure intact ev plant remain challeng varieti method util isol plant ev apoplast wash fluid awf compar publish plant ev isol method provid recommend method isol purif plant ev method includ detail protocol clean awf collect arabidopsi thaliana leav follow ev isol via differenti centrifug separ purifi specif subclass ev heterogen vesicl popul densiti gradient ultracentrifug immunoaffin captur util found immunoaffin captur precis method specif ev subclass isol suitabl specif ev biomark correspond antibodi avail overal studi provid guid select optim ev isol method desir downstream applic | D017360;D000067128 | T026;T002 |
34,668,638 | undergradu research experi vehicl employ develop student particip speak employ scienc graduat key concern employ report stem graduat lack appropri employ skill work experi scienc graduat take longer find full time work graduat mani program undergradu research experi ure import pedagogi involv student immers profession research environ provid opportun scienc student develop understand world work develop employ studi examin student reflect ure learn result perceiv employ ask whether student understand valu ure employ develop vehicl consid done improv employ learn ure result show student articul multipl learn ure struggl translat learn employ non research work context conclud ure import opportun learn work scienc ure student would benefit ure curriculum compon foreground way ure help develop student employ insight studi help inform refin futur ure program improv efficaci vehicl benefit graduat employ | D003479;D013334 | T065;T170;T098;T081 |
34,668,637 | cardiovascular risk profil cross section studi evalu generaliz glucagon like peptid receptor agonist cardiovascular outcom trial rewind leader sustain real world type diabet popul unit kingdom determin proport uk patient type diabet td meet cardiovascular cv combin cvcore elig criteria use cv outcom trial cvot uk market glucagon like peptid receptor agonist glp ras show cv benefit dulaglutid rewind liraglutid leader inject semaglutid sustain | D002318;D003924 | T047 |
34,668,636 | metastat colorect cancer type diabet prognost genet interact present studi undertaken analyz prognost genet interact type diabet metastat colorect cancer patient surviv depict kaplan meier product limit method prognost factor examin cox proport hazard regress model associ diabet clinic patholog variabl evalu test total metastat colorect cancer patient enrol lymph node p distant organ distant site p frequent involv diabet patient compar without diabet diabet independ statist signific negat prognost valu surviv high select patient cancer andor diabet ill es divid three group seven oligo metastat patient without diabet b poli metastat patient without diabet c poli metastat diabet patient group patient genet character illumina novaseq san diego ca usa platform trusigtoncolog kit focus gene involv diabet colorect cancer gene variant associ diabet cancer frequent patient group found type diabet negat prognost factor surviv colorect cancer diabet associ gene variant could concur malign provid ration basi innov model tumor progress therapi | D009362 | T191 |
34,668,635 | dual jakaurora kinas inhibit prevent human skin graft reject allo inactiv ilc mediat tissu repair prevent allograft reject often requir lifelong immun suppress risk broad impair host immun nonselect inhibit host cell function increas recipi risk opportunist infect secondari malign demonstr aji dual inhibitor jak aurora kinas amelior skin graft reject human cell provid durabl allo inactiv aji signific reduc frequenc skin home cla donor cell limit allograft invas tissu destruct effector aji also suppress pathogen th th cell spleen yet spare benefici regulatori cell show dual jakaurora kinas blockad enhanc human type innat lymphoid cell ilc respons capabl tissu repair ilc differenti mediat gata requir stat phosphoryl pstat oppos stat demonstr aurora kinas activ correl low pstat ilc import aji maintain pstat level ilc block aurora kinas reduc interfer stat therefor combin jakaurora kinas inhibit innov strategi merg immun suppress tissu repair transplant | D064096;D007113 | T032;T116;T126 |
34,668,634 | participatori codesign patient involv learn health system data driven care patient driven care learn health system lhs model routin collect health data use improv care creat virtuous cycl data improv requir activ involv health servic stakehold includ patient howev date research explor accept data donor rather consid patient activ contributor studi aim understand patient activ involv lhs | D000080891 | T058 |
34,668,632 | retin venular oxygen satur associ non prolif diabet retinopathi young patient type diabet determin contribut retin vessel densiti vd central retin vessel diamet retin oxygen satur independ known risk factor develop non prolif diabet retinopathi npdr | D003922;D003930 | T047 |
34,668,631 | target eifebp mir p affect function b lymphocyt via autophagi aggrav sle diseas progress excess activ immun cell play key role pathogenesi system lupus erythematosus sle regul immun cell mirna research hotspot studi second generat high throughput sequenc reveal reduct mir p express patient sle howev specif mechan under phenomenon remain unclear transfect mir p agomir prolifer ball cell decreas level apoptosi increas opposit effect observ cell transfect mir p antagomir luciferas report assay indic mir p direct target eifebp rescu experi confirm propos interact mir p eifebp vitro vivo clinic investig confirm mir p agomir reduc express eifebp lcb lamp vivo experi serum level anti nuclear antibodi doubl strand dna ige igm il il b lymphocyt stimul higher mice antagomir group mice mrllpr group furthermor protein mrna level eifebp lcb lamp intens immunohistochem stain eifebp lcb lamp urinari protein level c immunofluoresc deposit increas mice antagomir group upregul mir p express protect b cell eifebp mediat autophagi whilst downregul mir p express induc autophagi via eifebp mediat regul autophagi signal pathway b cell isol individu sle base result mir p eifebp may consid potenti target sle treatment | D005786 | T045 |
34,668,629 | risk factor myocardi injuri admiss patient coronavirus diseas shanghai china myocardi injuri lead higher mortal covid caus risk factor variabl evalu potenti risk factor myocardi injuri covid patient improv treatment strategi reduc mortal | D000086382 | T047;T067 |
34,668,627 | climat warm promot determinist assembl arbuscular mycorrhiz fungal communiti arbuscular mycorrhiz fungi amf signific contribut plant resourc acquisit play import role mediat plant interact soil carbon c dynam howev remain unclear amf communiti respond climat chang assess impact warm precipit alter increas decreas soil amf communiti examin major ecolog process shape amf communiti assemblag tibetan alpin meadow result show warm signific increas root biomass avail nitrogen n phosphorus p soil precipit alter increas amf abund signific affect composit divers amf communiti contrast warm alter composit amf communiti reduc shannon wiener index pielou even particular warm shift amf communiti composit favor diversisporacea glomeracea like impact soil n p avail addit amf communiti phylogenet random unwarm control cluster warm plot impli determinist communiti assembl climat warm warm enhanc root growth n p avail like reduc plant c alloc amf impos stronger environment filter amf communiti propos conceptu framework integr biolog geochem process mechanist understand warm precipit chang effect amf taken togeth result suggest soil amf communiti may sensit warm expect highlight need monitor communiti structur associ function consequ plant communiti soil c dynam futur warmer climat | D000072761;D038821 | T004 |
34,668,624 | discoveri mechan action small molecul inhibitor ceramidas sphingolipid metabol tight control enzym regul essenti process human physiolog central metabolit ceramid pro apoptot lipid catabol ceramidas enzym produc pro prolif sphingosin phosphat alkalin ceramidas transmembran enzym recent attract attent drug develop fatti liver diseas howev due hydrophob natur specif small molecul inhibitor report present discoveri mechan action first drug like inhibitor alkalin ceramidas acer particular chemic engin novel fluoresc ceramid substrat enabl screen larg compound librari character enzym inhibitor interact use mass spectrometri md simul addit reveal new paradigm inhibit lipid metabolis enzym non lipid small molecul data lay ground target acer drug discoveri effort | D055572 | T116;T126 |
34,668,623 | bloodstream bacteri infect thalassem pediatr adolesc patient hematopoiet stem cell transplant thalassem patient usual requir regular blood transfus howev hsct provid cure incid ibi pediatr patient post hsct still scant | D018380 | T061 |
34,668,621 | systemat credit california forest carbon offset program carbon offset wide use individu corpor govern mitig greenhous gas emiss assumpt offset reflect equival climat benefit achiev elsewher climat equival claim depend offset provid real addit climat benefit beyond would happen counterfactu without offset project evalu design california promin forest carbon offset program demonstr climat equival claim fall far short basi direct observ evid design california program award larg volum offset credit forest project carbon stock exceed region averag paradigm allow advers select could occur project develop preferenti select forest ecolog distinct unrepres region averag digit analyz comprehens offset project record alongsid detail forest inventori data provid direct evid compar project coars region carbon averag led systemat credit million tco e ci million tco e credit analyz ci excess credit worth estim million ci million recent market price rather improv forest manag store addit carbon california forest offset program creat incent generat offset credit reflect real climat benefit | D002244;D000074382 | T121;T196;T197 |
34,668,618 | situ electroneg bridg chemic bond concept one challeng chemistri plethora often dispar model ration electron structur molecul chemic concept abound connect often frail work describ quantum mechan framework enabl combin idea three approach common analysi chemic bond energi decomposit analysi eda quantum chemic topolog molecular orbit mo theori glue theori electron energi densiti interpret one part electron one part electroneg present three dimension analysi electron energi densiti use redefin constitut atom molecul definit atom partial charg electroneg follow way connect concept total energi molecul format polar bond predict caus invers electroneg new perspect bond diboran guanin cytosin base pair present electroneg atom insid molecul shown predict pk | D004583 | T196;T081 |
34,668,617 | model temperatur driven chang speci associ across freshwat communiti due global climat chang induc shift speci distribut estim chang communiti composit use speci distribut model becom key manag tool abl determin speci associ chang along environment gradient like pivot explor magnitud futur chang speci distribut particular import connect limit ecosystem freshwat ecosystem increas human transloc creat speci associ previous unseen environment gradient use larg scale presenc absenc dataset freshwat fish lake across fennoscandian region joint speci distribut model measur effect temperatur speci associ identifi trend negat associ speci toler cold water toler warmer water well posit associ sever warm toler speci associ often shift depend local temperatur result confirm freshwat ecosystem expect see larg scale shift toward communiti domin warm toler speci remain much work done predict exact local extinct may take place model implement provid start point explor climat driven communiti trend approach especi inform regard determin speci associ central shape futur communiti composit area vulner local extinct | D057231;D017753 | T070;T082 |
34,668,615 | acut kidney diseas predict chronic kidney diseas pediatr non kidney solid organ transplant patient acut kidney diseas akd defin impair kidney function present day without acut kidney injuri aki event adult akd increas risk progress chronic kidney diseas ckd mortal data epidemiolog akd children transplant aim studi evalu incid risk factor aki akd ckd children transplant | D058186;D016377;D051436 | T061;T047;T037 |
34,668,614 | steroid withdraw heart transplant adult corticosteroid css key compon immunosuppress treatment heart transplant htx effect prevent acut reject sever advers effect includ diabet hypertens osteoporosi hyperlipidemia associ long term use complic may impair long term outcom htx recipi withdraw css high desir howev uniform approach exist previous experi suggest cs withdraw accomplish without increas incid acut reject even carri surviv benefit also common complic relat long term cs use appear less frequent follow cs discontinu recipi success discontinu css howev like belong immun privileg subset patient low risk post transplant complic avail studi evalu cs withdraw high heterogen consensus optim time elig withdraw lack effort improv understand optim cs withdraw strategi great import order safe promot cs wean elig patient therebi allevi advers effect long term cs use post transplant outcom purpos review evalu differ protocol cs withdraw htx term clinic outcom explor criteria success cs withdraw | D006084;D016027 | T042;T061 |
34,668,612 | loss smarcb promot autophagi facilit tumour progress chordoma transcript activ atg swisnf relat matrix associ actin depend regul chromatin subfamili b member smarcb loss associ poor prognosi chordoma mechan remain larg unclear aim explor function regulatori mechan smarcb chordoma | D001343;D015972 | T043;T045 |
34,668,610 | short versus prolong antibiot treatment complic urinari tract infect kidney transplant consensus regard optim durat antibiot therapi urinari tract infect uti follow kidney transplant kt perform retrospect studi compar short day versus prolong day antibiot therapi complic uti among kt recipi univari invers probabl treatment weight iptw adjust multivari analysi composit primari outcom caus mortal readmiss within day relaps uti day perform overal kt recipi complic uti includ short cours treatment median interquartil rang iqr day prolong cours median iqr day composit outcom occur short cours group prolong cours group relaps uti occur vs respect durat antibiot treatment associ outcom risk factor mortalityreadmiss multivari analysi deceas donor differ group demonstr length hospit stay rate bacteraemia resist develop serum creatinin day conclus found differ clinic outcom kt recipi treat complic uti short cours antibiot day versus longer cours day | D016470;D016030;D014552 | T047;T061 |
34,668,609 | translat habitat class land cover map area habitat terrestri vertebr area habitat aoh defin habitat avail speci habitat within rang calcul subtract area unsuit land cover elev rang intern union conserv natur iucn habitat classif scheme provid inform speci habitat associ typic unvalid expert opinion use match habitat land cover class generat sourc uncertainti aoh map develop data driven method translat iucn habitat class land cover base point local data speci terrestri mammal bird amphibian reptil extract land cover class point local match iucn habitat class class assign speci occur model land cover class function iucn habitat ssg use logist regress model result odd ratio use assess strength associ habitat land cover class compar perform data driven model publish translat tabl base expert knowledg calcul associ habitat class land cover class continu variabl map aoh binari presenc absenc necessari appli threshold associ threshold chosen user accord requir balanc omiss commiss error habitat eg forest desert assign land cover class confid other eg wetland artifici data driven translat model expert knowledg perform equal well model provid greater standard object repeat furthermor approach allow greater flexibl use result uncertainti quantifi model modifi region examin differ taxonom group | D003247;D017753 | T082;T064;T078;T081;T070;T069 |
34,668,608 | qualit systemat review govern principl mangrov conserv manag mangrov ecosystem complex given mangrov terrestri marin often cross region nation boundari valu local stakehold differ way valu nation intern scale thus mangrov govern vari level success analyz concept principl good govern procedur justic decis make although substanti research case studi mangrov manag global comparison mangrov govern lack research aim fill gap compar relationship among qualiti govern across mangrov social ecolog system worldwid systemat literatur search screen process identifi articl discuss mangrov govern conserv case studi articl drawn countri categor top bottom comanag themat code assess influenc eight principl good govern mangrov conserv success across three govern system principl legitimaci fair integr import determin conserv success failur principl close relat concept procedur justic highlight import stakehold inclus throughout stage mangrov manag thus recommend clear defin role govern actor transpar communic polici develop stakehold fair process outcom care consider sustain access conserv resourc | D003247;D017753 | T082;T064;T078;T081;T070;T069 |
34,668,605 | uterus procur deceas donor transplant women absolut uterin factor infertil get pregnant current experi uterin transplant limit use deceas donor uterus area incipi initi unsuccess attempt birth healthi babi modal four differ center given new impetus use transplant techniqu aim develop techniqu uterus procur prepar transplant brain dead donor fifteen uteri retriev multi organ donor patient use bench surgeri propos techniqu procedur perform obtain famili consent studi allow clinic use two organ procur transplant one organ result first live birth worldwid use uterus transplant deceas donor landmark reproduct medicin anoth outcom optim surgic techniqu involv less manipul uterin vascular pedicl success novel techniqu suggest propos model replic optim facilit transplant uterus deceas donor | D007247 | T033;T047;T046 |
34,668,604 | evalu hepat iron overload use contemporari mri system mri r map gain clinic accept noninvas assess iron overload lower field mri may offer increas measur dynam rang patient high iron concentr may potenti increas mri access compromis lower signal nois ratio reduc measur precis | D019190 | T047 |
34,668,603 | brain function effect connect base electroencephalographi record review function connect effect connect human brain repres statist depend direct inform flow cortic region signific contribut studi intrins brain network function mechan mani recent studi electroencephalographi eeg focus model estim brain connect due increas evid help better understand various brain neurolog condit howev lack comprehens updat review studi eeg base brain connect particular visual option associ machin learn applic aim translat techniqu use clinic tool articl review eeg base function effect connect studi undertaken last year term estim visual applic associ machin learn classifi method explor discuss various dimens either linear nonlinear parametr nonparametr time base frequenc base time frequenc base follow novel review brain connect visual method group heat map data statist head map aim explor variat connect across differ brain region final current challeng relat research roadmap futur relat research present | D063132;D000069550 | T091;T017;T066 |
34,668,602 | axe multivari sexual signal diverg among incipi speci concord select genet variat phenotyp plastic sexual signal trait often observ diverg rapid among popul therebi play potenti key earli role evolut reproduct isol often assum reflect diverg sexual select among popul pattern sexual trait diversif might sometim bias along axe stand addit genet variat covari among trait compon addit theori predict environment induc phenotyp variat might facilit rapid trait evolut suggest pattern diverg popul mirror phenotyp plastic within popul evalu concord observ axe multivari sexual trait diverg predict diverg base interpopul variat sexual select addit genet varianc temperatur relat phenotyp plastic male courtship song among geograph isol popul hawaiian swordtail cricket laupala cerasina exhibit sexual isol due acoust signal trait major axi multivari diverg max account variat among popul male song trait mean moder correl interpopul differ direct sexual select base femal prefer howev major addit genet varianc larg orient away direct diverg suggest stand genet variat may play domin role pattern signal diverg contrast axi phenotyp plastic strong mirror pattern interpopul phenotyp diverg consist role temperatur relat plastic facilit instead inhibit male song evolut sexual isol incipi speci propos potenti mechan sexual select might interact phenotyp plastic facilit rapid acoust diversif observ speci clade | D000819;D006135 | T204;T054 |
34,668,601 | transfer learn strategi base unsupervis learn ensembl learn breast cancer molecular subtyp predict use dynam contrast enhanc mri imag driven deep learn strategi focus train scratch transfer learn howev perform train scratch often imped lack larg scale label train data addit owe differ sourc target domain analyz medic imag task satisfactorili via transfer learn base imagenet difficult | D001943 | T191 |
34,668,600 | digit support public health intervent len structur injustic case mobil app respond violenc women girl mobil applic app gain signific popular new intervent strategi respond violenc women girl despit grow relev assess perspect public health ethic still lack base discuss understand violenc women girl multidimension global public health issu structur societ individu level situat within theoret framework structur injustic includ epistem injustic base systemat app review previous conduct evalu content function app len structur injustic argu technolog solut app may use tool fight violenc women girl situat within broader frame public health consid structur dimens violenc ultim concern rais structur injustic alongsid key concern safeti data privaci import human support contact forth crucial dimens ethic assess app howev research role relev app strategi address structur epistem dimens violenc remain scarc articl aim provid foundat discuss area could applic area public health polici practic | D063731 | T170 |
34,668,599 | global ecolog signal extinct risk terrestri vertebr determin distribut caus extinct threat across function group terrestri vertebr assembl ecolog trait data set speci terrestri vertebr util phylogenet compar method test categori habitat associ mode locomot feed mode best predict extinct risk also examin individu categori intern union conserv natur red list extinct driver eg agricultur log threaten speci determin greatest threat four terrestri vertebr group quantifi sum extinct driver threaten speci provid multistressor perspect threat cave dwell amphibian p arbor quadruped mammal primat p aerial scaveng bird p pedal ie walk squamat p disproportion threaten extinct comparison assess ecolog trait across threaten vertebr speci studi common risk factor agricultur threaten speci follow log threaten speci invas speci diseas threaten speci speci higher risk extinct simultan risk greater number threat type left unab disproportion loss speci certain function trait increas anthropogen pressur like disrupt ecosystem function global shift focus speci trait centric conserv practic allow protect risk function divers region global scale | D017753;D053476 | T070;T082 |
34,668,598 | effect forest cover rich threaten fish speci japan estuari one vulner ecosystem global face anthropogen threat includ biodivers loss collaps sustain fisheri determin factor contribut mainten estuarin biodivers especi fish vital promot estuarin conserv sustain use environment dna metabarcod analysi determin fish speci composit estuari around japan measur watersh scale land use factor eg popul size urban area percentag forest area percentag sought test hypothesi rich vulner estuarin fish speci ie regist japanes ministri environ nation speci red list determin watersh scale land use factor rich speci greater forest cover highest thus forest cover contribut conserv proport agricultur cover associ low speci rich red list fish redund analysi adjust r total varianc df f p number red list speci increas along watersh land use gradient rang high proport agricultur cover larg proport forest cover furthermor result show throughout japan examin watersh cover forest averag speci per site rich red list fish speci result attribut alreadi high averag forest cover japan result demonstr land use watersh affect coastal sea environ biodivers suggest proper forest manag conjunct land use manag may prime import threaten fish speci coastal ecosystem general | D017753;D056727 | T070;T082;T098 |
34,668,597 | high qualiti diet physic activ colleg educ associ low risk nafld among us popul effect diet qualiti dq physic activ pa socioeconom status ses risk nafld unclear examin associ among dq pa ses nafld risk | D065626 | T047 |
34,668,596 | rational design multi center prospect random control trial effect sacubitril valsartan versus enalapril left ventricular remodel st elev myocardi infarct peri stemi studi angiotensin receptor neprilysin inhibitor arni sacubitril valsartan recommend one first line therapi heart failur reduc eject fraction howev whether arni could benefit patient st segment elev myocardi infarct stemi improv left ventricular lv remodel remain unknown primari object peri stemi trial assess whether sacubitril valsartan effect prevent advers lv remodel patient stemi enalapril | D006333;D000072657 | T047;T046 |
34,668,595 | new report system diagnosi hepatocellular carcinoma chronic hepat b clinic gadoxet acid enhanc mri featur current major guidelin diagnosi hepatocellular carcinoma hcc base imag find differ includ clinic risk factor diagnost criteria | D006528;D019694;D008113 | T191;T047 |
34,668,594 | compar blood cultur contamin rate differ sampl method paediatr emerg depart blood cultur contamin bcc caus unnecessari hospitalis inappropri use antibiot aim studi find risk factor associ bccs children compar contamin rate open close blood cultur collect system | D000071997;D001800 | T059;T060 |
34,668,593 | discoveri structur activ relationship quinolinequinon promis antimicrobi agent mode action evalu pursuit develop novel potent select antimicrobi agent manag obtain quinolinequinon antimicrobi profil minim inhibitori concentr mic determin panel seven bacteri strain three gram posit four gram negat bacteria three fungi structur activ relationship sar quinolinequinon class antimicrobi determin interest qq qq qq qq qq display equal antibacteri potenti aureus mic mgl respect standard posit control cefuroxim na qq best inhibitori activ mic valu mgl fourfold potent compar refer standard clotrimazol candida albican hand qq effect gram posit bacteria much analog qq effect quinolinequinon fungi select quinolinequinon evalu mode action use vitro antibiofilm activ bactericid activ use time kill curv assay antibiofilm activ potenti antimicrobi activ clinic obtain resist strain gram posit bacteria result also reveal qq specif antifung activ fungi particular c albican result clear show quinolinequinon much activ inhibit biofilm attach process inhibit matur biofilm format thus treatment option narrow methicillin resist staphylococcus spp vancomycin resist staphylococcus spp daili quinolinequinon report herein display promis lead candid clinic applic serious infect | D000890;D055624 | T007;T121 |
34,668,592 | creation inventori qualiti marker use evalu pharmacokinet literatur systemat review robust critic apprais tool clinic pharmacokinet studi limit develop tool possibl qualiti marker item deem import credibl studi result must identifi aim creat inventori qualiti marker intend apprais clinic pharmacokinet studi categor identifi marker associ domain studi qualiti | D010599;D011786 | T062;T169;T039 |
34,668,591 | review articl drug induc small bowel injuri drug induc gastrointestin injuri increas report exact incid known small larg intestin repres affect site injuri account gastrointestin side effect | D015212;D004364 | T047;T121 |
34,668,590 | doxorubicin induc delay onset subclin cardiotox mice subclin cardiotox low total cumul doxorubicin dox dose manifest cardiomyopathi long term cancer survivor howev under mechan poor understood male bcf mice assess cardiac function echocardiographi perform week exposur mgkg total cumul dox dose salin sal monitor develop delay onset cardiotox mgkg total cumul dose result signific time depend declin systol function left ventricular eject fraction lvef fraction shorten fs week recoveri although signific alter lvef fs specif time point recoveri signific declin systol function elicit cardiotox cumul dox dose mgkg week period treatment compar sal treat counterpart week dox treatment signific dose relat decreas express gene protein involv sarcoplasm reticulum sr calcium homeostasi ryr serca associ dose relat increas transcript level casp sr specif apoptosi heart mice also show enhanc apoptot activ heart indic signific dose relat elev number apoptot cardiomyocyt compar sal treat counterpart find collect suggest steadi declin sr calcium handl apoptosi might involv develop subclin cardiotox evolv irrevers cardiomyopathi later life | D009202;D066126 | T047;T037 |
34,668,589 | compens beam modul due microscop lung heterogen carbon ion therapi treatment plan predict mitig degrad physic biolog effect dose distribut particl beam caus microscop heterogen lung tissu | D063193;D061766 | T061 |
34,668,588 | nk cell base therapi hiv infect investig current advanc futur possibl nk cell well known antivir function also role hiv well establish rapid respons elicit earli hiv infect immun cell includ cd cell monocyt ms dendrit cell readili infect hiv recent evid multipl studi suggest similar cell chronic condit like hiv nk cell also undergo function exhaust impair cytotox alter cytokin product impair adcc nk base immunotherapi aim success restor boost modifi activ alreadi demonstr field cancer immunotherapi util nk cell base strategi erad hiv bodi provid mani advantag classic art literatur search consist manual select relev studi databas includ pubm embas googl scholar clinicaltrialgov treatment current consider car nk cell therapi facilit adcc tlr agonist bnab bikestrik block inhibitori nk receptor infect il il superagonist eg alt review aim discuss nk cell base therapi current experiment hiv infect final highlight challeng associ nk cell base immunotherapi | D015658 | T047 |
34,668,586 | growth puberti testicular function boy born small gestat age nonspecif disord sex develop born small gestat age sga frequent associ unexplain disord sex develop nonspecif dsd boy littl known futur growth puberti testicular function object determin long term endocrin outcom boy born sga nonspecif dsd | D007236;D011627 | T033;T039 |
34,668,585 | econom burden anxieti depress work age popul diabet spain diabet mellitus dm complex chronic multifactori cost health problem repres total public health expenditur spain object studi analys preval cost anxieti ax depress dp spanish work popul dm data obtain nation health survey spain multivari analysi conduct predict use resourc absenteeismpresente direct indirect cost calcul final popul analys contain subject year old dm preval ax dp men self diagnos health rate regular poor poor dm subject dp ax averag cost estim dm subject ax dp dm total estim econom impact dm spanish gross domest product direct relat dp ax indirect cost repres total dp ax cost spanish societi pay consider price incid dp ax level dm work popul global challeng import repercuss individu qualiti life health system countri develop econom growth | D003920;D011788 | T047;T078 |
34,668,583 | malt proteas function regulatori cell induc myc activ promot mitochondri function cellular expans regulatori cell treg essenti inhibit immun mainten tissu homeostasi signal cell antigen receptor tcr critic earli treg develop expans inhibitori activ although tcr engag activ paracaspas malt import treg activ malt effector pathway treg remain ill defin demonstr malt proteas activ control tcr induc upregul transcript factor myc subsequ express myc target gene treg mechan import treg intrins mitochondri function optim respiratori capac homeostat treg prolifer consist condit delet myc treg result similar malt inactiv lethal autoimmun inflammatori syndrom togeth result identifi malt proteas mediat link tcr signal treg myc control coordin metabol treg expans mainten immun homeostasi | D049109;D008213 | T043 |
34,668,582 | select fetal growth restrict type iii applic recent expert consensus definit per recent expert definit diagnosi select fetal growth restrict sfgr monochorion diamniot twin base estim fetal weight efw sole criterion andor combin contributori criteria twin efw twin abdomin circumfer th percentil assess criteria sfgr type iii intermitt absent revers end diastol flow ua iaredf patient test whether meet stringent paramet consensus definit wors outcom progress sfgr type ii persist aredf twin twin transfus syndrom secondarili decreas dual survivorship | D005317;D016216 | T046;T060 |
34,668,581 | spank extern problem examin within subject associ studi examin effect spank extern within subject level exclud causal irrelev subject varianc result two longitudin studi use particip child develop project n reanalyz random intercept cross lag panel model use year measur age remov subject varianc signific effect general spank extern howev done without object rate per month less spank show benefici effect result suggest previous find may due failur separ subject within subject varianc addit result illustr need examin limit spank separ general form physic punish | D002657;D011678 | T040;T039;T078 |
34,668,580 | toler induct liposom target singl cd epitop igrp model type diabet imped co target cd islet epitop autoimmun diseas type diabet predomin mediat cd cytotox cell destruct islet beta cell islet specif glucos phosphatas catalyt subunit relat protein igrp domin target antigen specif previous found liposom base antigen specif immunotherapi encapsul cd cell islet epitop mim togeth nuclear factor b inhibitor calcitriol induc regulatori cell protect diabet nod mice investig whether system deliv igrp could induc antigen specif cd cell target immun regul delay diabet subcutan administr igrp calcitriol liposom transient activ expand igrp specif cell receptor transgen cd cell liposom co deliveri calcitriol requir optim suppress endogen igrp specif cd cell interferon product cytotox concord short cours igrp calcitriol liposom delay diabet progress reduc insul howev igrp calcitriol liposom deliv togeth mim calcitriol liposom diseas protect observ regulatori effect mim calcitriol liposom abrog thus tolerogen liposom target either domin cd cd cell islet epitop delay diabet progress combin multipl epitop enhanc protect | D003922 | T047 |
34,668,579 | feed young children class cultur analysi food parent practic studi unpack class process shape understand practic good feed famili young children bring bourdieusian class consumpt focus togeth food parent studi approach feed encompass wide rang process includ cook shop plan captur live experi feed work studi draw longitudin ethnograph studi conduct south east england cours two year analysi suggest regardless resourc parent tend intern domin discours healthi vari feed howev closer inspect day day practic reveal nuanc class cultur pattern term defin achiev moreov reveal differ interpret key notion homemad nutriti balanc generat practic contribut cultiv distinct class culinari agenc children studi also question potenti role understand play reproduc tast hierarchi maintain symbol boundari earli age | D005247;D016487 | T040;T054;T055 |
34,668,578 | demonstr general structur cell type fat bodi blatta orientali orient cockroach fat bodi tissu origin mesoderm insect consist sever cell type basic cell fat bodi trophocyt glycogen protein lipid requir energi store cell mycetocyt urocyt chromotocyt haemoglobin cell cell type origin differenti trophocyt cell found cockroach mycetocyt contain endosymbiont speci bacteria urocyt special cell store discharg uric acid oenocyt fat bodi cell type associ epidermi fat bodi cell also found cockroach research fat bodi distribut shown first time three select section thorax begin end abdomen stage blatta orientali linnaeus addit fat bodi cell type distribut determin histolog histochem ultrastructur studi result trophocyt mycetocyt urocyt fat bodi oenocyt relat fat bodi determin b orientali also reveal fat bodi content increas select region stage depend develop hope find contribut data fat bodi give direct insecticid studi | D003058;D005216 | T204;T023 |
34,668,576 | role autophagi follicular develop mainten primordi follicular pool ovari reproduct life span organ main depend follicular develop maintain primordi follicl pool cohort follicl within ovari total count primordi follicl decreas age due ovul follicular atresia follicular atresia process ovarian follicl degrad main occur via apoptosi recent studi also favor autophagi exist autophagi cellular energi homeostat respons help maintain number healthi primordi follicl germ cell surviv remov corpus luteum remnant excess autophag cell death chang qualiti quantiti oocyt ultim affect femal reproduct health autophagi regul occur various autophagi regul gene like becn lc ii autophagi marker gene abnorm regul mutat high influenc follicular develop alter primordi follicl format declin oocyt count germ cell loss various classic signal pathway pikaktmtor mapkerk ampk ire involv granulosa oocyt autophagi mtor signal primari mechan along basal level autophagi chemicalhormonestress mediat autophagi also affect follicular develop femal reproduct review primarili focus granulosa cell oocyt autophagi mechan role autophagi determin marker gene follicular develop | D005496;D010053 | T023;T042 |
34,668,575 | variabl environment persist per capita transmiss rate amphibian chytrid fungus lead differ host infect preval heterogen infect among host popul may aris differ environment condit two mechan first environment condit may alter host exposur pathogen via effect surviv second environment condit may alter host suscept make infect less like contact host pathogen occur host suscept might alter acquir resist host develop system exposur dead decay pathogen metabolit environment condit may alter rate pathogen decomposit influenc likelihood host develop acquir resist present studi primarili test environment context influenc relat contribut pathogen surviv per capita transmiss host infect preval use amphibian chytrid fungus batrachochytrium dendrobatidi bd model system secondarili evalu environment context influenc decomposit bd previous studi shown dead bd metabolit illicit acquir resist host conduct bd surviv infect experi fit model discern bd mortal decomposit per capita transmiss rate vari among water sourc eg artifici spring water asw water three pond found infect preval differ among water sourc driven differ mortal rate bd rather differ per capita transmiss rate bd mortal rate vari among pond water treatment lower asw compar pond water result suggest variat bd infect dynam could function environment factor waterbodi result differ exposur host live bd contrast persist live bd found rate decomposit dead bd vari among water sourc may suggest exposur host dead bd metabolit might common vari among nearbi site ultim mechanist understand environment depend free live pathogen could lead deeper understand pattern outbreak heterogen could inform surveil manag strategi | D008411;D009181 | T004;T047 |
34,668,573 | clarifi associ eat disord featur suicid ideat attempt examin relationship eight eat disord ed featur histori suicid ideat suicid attempt | D001068;D059020 | T033;T048;T047 |
34,668,572 | prognost factor recurr afebril seizur benign convuls associ mild gastroenter overal prognosi benign convuls associ mild gastroenter cwg favor incid afebril seizur recurr without gastroenter aswgi aswogi respect low studi investig prognost factor associ afebril seizur relaps first cwg episod | D005759 | T047 |
34,668,571 | tempor scale habitat select larg carnivor balanc energet risk find prey navig heterogen landscap larg carnivor must balanc trade off multipl goal includ minim energet expenditur maintain access hunt opportun avoid potenti risk human relat import goal drive carnivor movement like chang across tempor scale understand dynam remain limit quantifi driver movement habitat select chang tempor grain two larg carnivor speci live human domin landscap provid insight common carnivor movement strategi across region use high resolut gps collar data integr step select analys model movement habitat select african lion panthera leo laikipia kenya puma puma concolor santa cruz mountain california across eight tempor grain rang min hr analys consid landscap covari relat energet resourc acquisit anthropogen risk speci topograph slope strong influenc energet expenditur drove habitat select movement pattern fine tempor grain less import longer tempor grain contrast avoid anthropogen risk day risk highest consist import across grain degre carnivor relax avoid night strongest longer term movement lion puma modifi movement behaviour differ respons anthropogen featur lion sped near human fine tempor grain puma slow develop area coars tempor grain final puma experienc trade energet effici movement avoid anthropogen risk tempor grain import methodolog consider habitat select analys driver movement habitat select chang across tempor grain addit grain depend pattern reflect meaning behaviour process includ fit relev goal influenc behaviour differ period time appli multi scale analysi fine resolut data show two larg carnivor speci differ human domin landscap balanc compet energet safeti demand larg similar way common suggest general strategi landscap use across larg carnivor speci | D002335;D008045;D046011 | T008;T015 |
34,668,570 | incongru phylogeni implic studi diversif taxonomi genom size evolut rhododendron classif taxa depend qualiti infer phylogeni rhododendron high speci rich genus speci woodi plant high debat infragener classif due huge divers homoplasi key charact incongru among data set provid broad coverag repres speci resolv rhododendron infragener phylogeni highlight area incongru investig effect polyploidi genom size evolut diversif rhododendron | D029793 | T002 |
34,668,569 | cancer health self efficaci improv random control trial ehealth intervent help cancer survivor self manag health outsid clinic littl known best engag assist survivor across age cancer treatment spectra | D000073116;D009369;D000073278;D017216 | T058;T191;T101;T201 |
34,668,568 | morpholog trait match plant hymenoptera plant diptera mutual across elev gradient morpholog trait match speci abund thought main factor affect frequenc strength mutualist interact howev relat import trait match speci abund shape speci interact across environment gradient remain poor understood especi plant insect mutual involv generalist speci characteris variat speci trait composit relat import trait match speci abund shape plant hymenoptera plant diptera mutual four meadow across elev gradient yulong snow mountain southwest china also evalu effect morpholog trait flower visitor plant composit forag specialis normalis degre high degre dissimilar composit hymenoptera diptera visitor visit plant communiti variat main driven spatial replac speci plant hymenoptera plant diptera network trait match nectar tube depth probosci length stronger predictor interact tempor co occur plant flower visitor speci abund fourth corner analys reveal statist signific trait match nectar tube depth probosci length plant hymenoptera network site suggest hymenoptera consist forag plant speci nectar tube depth match probosci length contrast signific trait match plant diptera network observ two lower elev site speci level specialis flower visitor increas signific probosci length differ nectar tube depth plant communiti plant visit flower visitor increas result highlight import trait match shape pairwis interact nich partit depend specif featur eg speci composit trait avail plant pollin system specialis plant hymenoptera system trait match import determin speci interact wherea generalist plant diptera system trait match relat unimport | D004175;D006927 | T204 |
34,668,567 | target nontarget detect character trace organ chemic human serum plasma use quecher extract human expos broad rang organ chemic although target gas chromatographi mass spectrometri techniqu use quantifi limit number persist organ pollut trace organ contamin biolog sampl nontarget high resolut mass spectrometri hrms method assess human exposom extens present quecher extract target nontarget analysi trace organ contamin use hrms compar method tradit cartridg base solid phase extract spe follow valid use refer spike serum sampl method appli plasma sampl n prospect investig obes energi metabol poem studi quantifi analyt use target analysi peak detect use nontarget approach target analyt least recov use quecher method spike serum sampl nontarget analysi peak method detect limit area count time greater use quecher method target compound also identifi nontarget analysi categor chemic assign ident use epa comptox dashboard chemic found least one list categori highest number chemic androgen estrogen receptor activ find demonstr quecher techniqu suitabl target nontarget analysi trace organ contamin biolog sampl | D009930;D052616 | T059;T109 |
34,668,566 | associ residenti exposur volatil organ compound liver injuri marker occup exposur volatil organ compound voc associ numer health complic includ steatohepat liver cancer howev potenti impact environmentalresidenti voc exposur liver health function larg unknown address knowledg gap object cross section studi investig associ voc liver injuri biomark communiti resid subject recruit six louisvill neighborhood inform consent obtain exposur biomark includ creatinin adjust urinari metabolit correspond parent voc serolog diseas biomark measur includ cytokertain k liver enzym direct bilirubin associ exposur diseas biomark assess use general linear model smoke status confirm urinari cotinin level popul compris approxim femal male white person account popul nonsmok n smoker n compar nonsmok male black person like smoker overal popul metabolit acrolein acrylonitril acrylamid butadien crotonaldehyd styren xylen posit associ alkalin phosphatas associ persist smoker except crotonaldehyd addit n n dimethylformamid propylen oxid metabolit although posit associ observ k benzen metabolit posit associ bilirubin irrespect smoke status taken togeth result demonstr select voc posit associ liver injuri biomark find enabl better risk assess identif popul vulner liver diseas | D055549 | T109 |
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