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34,692,616 | covid pandem bureaucraci crisi insid crisi medic intellig inform mi unit german arm forc bundeswehr experienc crisi support militari mission sinc sever year gain addit experi current coronavirus covid pandem differ level respons crisi request share find expertis overload civil public health agenc insid germani sinc begin pandem unit constant develop new product crisi communic knowledg share techniqu new databas dashboard leadership train layperson contact trace henc tri innov crisi sinc first sever acut respiratori syndrom coronavirus sar cov diseas wave second wave unit request evalu outbreak manag differ nation civil public health agenc southern germani support develop dashboard comprehens public health approach necessari start toward digit | D000086382;D058873 | T047;T067 |
34,692,615 | factor associ diagnost delay human brucellosi tongliao citi inner mongolia autonom region china diagnost delay pose huge challeng human brucellosi hb increas risk chronic complic heavi diseas burden studi aim quantifi identifi associ factor diagnost delay prevent reduct elimin studi analyz risk factor associ diagnost delay cross section studi data collect tongliao citi inner mongolia autonom region china diagnost delay defin cutoff day differ delay group risk factor diagnost delay analyz univari analysi model multivari logist regress analysi total case collect januari decemb median diagnost delay day interquartil rang iqr day logist regress analysi indic older age categori associ longer diagnost delay across group longer diagnost delay increas age among three delay group p trend occup herdsman associ shorter diagnost delay group day adjust odd ratio aor ci diagnost delay shorter patient brucellosi report cdc delay group aor ci ci ci pastoralagricultur area associ shorter diagnost delay group day aor ci group day aor ci stratifi analysi show older age categori associ increas risk long delay gender p older age group youth group increas along increas delay time p trend furthermor pastoralagricultur area associ shorter delay male p delay exist diagnosi hb pay great attent risk factor diagnost delay older popul non herdsman non pastoralagricultur area non diseas prevent control agenc effect measur shorten diagnost delay achiev earli detect diagnosi treatment reduc risk hb chronic complic econom burden | D002006;D057210 | T080;T047;T079 |
34,692,614 | connect care novel communiti outreach program vulner hous patient high acut care use mix method studi protocol introduct vulner hous individu especi experienc homeless higher acut care use compar general popul despit avail primari care social servic mani face signific challeng access need servic connect care cc novel transit case manag program includ regist nurs health navig complementari expertis chronic diseas manag mental health addict social program communiti health hous financi transport legal resourc cc bridg acut care communiti servic improv care coordin method analysi perform mix method evalu cc program accord donabedian framework structur process outcom understand program structur process coupl contextu factor influenc outcom novel intervent elig patient homeless unstabl hous adult complex health condit high acut care use chang emerg depart visit rate month program enrol primari outcom secondari outcom includ month post enrol hospit admiss cumul hospit day health relat qualiti life hous status primari care attach substanc use qualit method explor experi cc program multipl perspect econom evalu assess cost effect discuss academ research partner communiti servic provid evalu novel transit case manag intervent vulner hous patient high acut care use studi use mix method evalu connect care program accord donabedian framework structur process outcom includ assess contextu factor influenc program success insight gain comprehens evalu help refin cc program inform decis sustain transfer set canada | D006703;D006798 | T095;T073;T033;T098 |
34,692,569 | bacteri subvers autophagi cystic fibrosi cystic fibrosi cf genet diseas affect peopl worldwid caus mutat cftr gene chlorid ion transport local plasma membran lung epitheli cell organ loss cftr function alter chlorid bicarbon water transport plasma membran promot product thick sticki mucus bacteria includ pseudomona aeruginosa burkholderia cenocepacia produc chronic infect eventu decreas lung function increas risk mortal autophagi well conserv lysosom degrad pathway mediat pathogen clearanc play import role control bacteri infect mini review describ princip strategi use p aeruginosa b cenocepacia surviv avoid microbicid mechan within autophag pathway lead establish chronic inflammatori immun respons gradual compromis lung function life cf patient | D057508;D003550;D011552 | T007;T047 |
34,692,568 | role tlr schistosoma japonicum infect induc hepat patholog chang cbl mice japonicum infect induc granulomat inflamm liver host granulomat inflamm limit spread infect play role host protect toll like receptor tlr endosom tlr recogn singl strand rna ssrna studi role tlr japonicum infect induc hepat investig normal tlr knockout ko cbl mice result indic tlr ko could aggrav japonicum infect induc damag bodi less granuloma format tissu lower wbcs blood decreas alt ast serum express tlr detect isol hepat lymphocyt result indic percentag tlr cell increas infect mice hepat macrophag dcs b cell could express tlr tlr express cell liver infect mice macrophag percentag tlr express macrophag also increas infect moreov macrophag cell b cell show signific chang count activ associ molecul express cytokin secret japonicum infect wt tlr ko mice altogeth studi indic tlr could delay progress japonicum infect induc hepat main macrophag dcs b cell cell involv tlr mediat immun respons | D012554;D051199 | T192;T129;T047;T116 |
34,692,567 | function intricaci symmetri long non code rnas parasit infect rnas class molecul major eukaryot arbitrarili term non code transcript broad classifi short long non code rnas recent knowledg identif function long non code rnas continu accumul recogn import molecul regul parasit host interfac parasit differenti host respons diseas progress herein present integr function host parasit long non code rnas infect within context epigenet program molecular crosstalk cours host parasit interact also modular rang parasit host long non code rnas coordin parasit development chang host immun dynam landscap discuss equal canvass prospect long non code rnas diseas diagnosi prognosi hindsight suggest offer aim bolster understand futur work host parasit long non code rnas | D010272;D062085 | T047;T114;T123 |
34,692,566 | autophagi staphylococcus aureus infect staphylococcus aureus invas facult intracellular pathogen colon nich various host organ make difficult host immun system complet elimin host autophagi intracellular clearanc pathway involv degrad aureus wherea accessori gene regulatori system aureus control virul factor could resist host immun defens evad even util autophagi articl review interact autophagi aureus provid insight use mechan improv aureus infect control | D013203;D013211 | T007;T047 |
34,692,565 | explor pattern recognit receptor agonist candid adjuv adjuv use maxim potenc vaccin enhanc immun reaction compon adjuv includ pathogen associ molecular pattern pamp damag associ molecular pattern damp agonist innat immun receptor innat immun respons usual activ pathogen recognit receptor prrs recogn pamp deriv invad pathogen damp releas host cell upon tissu damag activ innat immun prr agonist adjuv activ acquir immun respons crucial enhanc immun reaction target pathogen exampl agonist toll like receptor yield promis result adjuv target prr adjuv candid howev comprehens understand type immunolog reaction agonist prrs essenti ensur safeti reliabl vaccin adjuv review provid overview current progress develop prr agonist vaccin adjuv molecular mechan underli activ immun respons enhanc vaccin efficaci potenti adjuv candid | D000276;D051192 | T192;T129;T121;T116 |
34,692,564 | potenti role glial cell neuropathogenesi cerebr malaria cerebr malaria cm sever neurolog complic malaria caus plasmodium falciparum parasit one lead caus death children year age sub saharan africa cm associ blood brain barrier disrupt long term neurolog sequela survivor cm despit vast amount research cerebr malaria caus neurolog sequela observ cm patient poor understood articl potenti role glial cell astrocyt microglia cerebr malaria pathogenesi review possibl mechan glial cell contribut neurolog damag cm patient also examin | D016779;D009422 | T047 |
34,692,563 | allevi effect gqd tradit chines medicin formula diabet rat link modul gut microbiom gegen qinlian decoct gqd chines herbal medicin report signific decreas blood glucos level suggest relat interact gut microbiota howev protect effect gqd intestin barrier function regard influenc gut microbiota explor date studi investig role gut microbiota mediat hypoglycem mechan gqd type diabet mellitus tdm rat induc singl intraperiton inject streptozotocin week high fat diet feed tdm rat random alloc receiv gqd metformin met salin consecut week chang metabol paramet intestin barrier function inflamm investig gut microbiota analyz use rrna gene sequenc fecal sampl statist analys perform correl microbiota composit phenotyp tdm rat gqd administr decreas level blood glucos inflammatori cytokin increas level tight junction protein besid gqd protect effect islet function restor intestin permeabl inhibit inflamm evidenc increas level serum c peptid occludin claudin colon also improv express serum inflammatori factor addit gqd regul structur gut microbiota increas proport short chain fatti acid produc anti inflammatori bacteria decreas proport condit pathogen bacteria associ diabet phenotyp overal find suggest gqd could amelior hyperglycemia protect islet function regul structur gut microbiota therebi restor intestin permeabl inhibit inflamm tdm rat studi thus suggest hypoglycem mechan gqd mediat modul gut microbiota | D003924;D004365;D000069196 | T007;T047;T121;T123;T001 |
34,692,562 | microbi biofilm decontamin dental implant surfac mini review insert bone implant osseointegr requir long term success howev inflamm infect around implant may lead implant failur lead peri implant loss support bone may eventu lead failur implant surfac chemistri implant lack cleanli part patient relat peri implant way get rid infect decontamin dental implant | D000890;D015921;D057873 | T047;T074;T121 |
34,692,561 | comparison red complex bacteria saliva subgingiv plaqu periodont patient systemat review meta analysi develop periodont associ imbalanc subgingiv microbi communiti enrich speci tradit classifi red complex bacteria porphyromona gingivali tannerella forsythia treponema denticola saliva suggest altern subgingiv plaqu microbi analysi due easi non invas collect systemat review aim determin whether level red complex bacteria assess use saliva reflect subgingiv plaqu periodont patient medlin embas cochran librari databas search april studi consid elig microbi data least one red complex speci report saliva subgingiv plaqu periodont patient base dna base method includ studi studi use rrna gene sequenc techniqu rest use pcr base approach detect frequenc red complex speci periodont patient report studi irrespect sampl type meta analys reveal detect frequenc relat abund red complex bacteria saliva signific lower subgingiv plaqu moreov relat abund bacteri speci saliva show signific posit correl subgingiv plaqu conclus current evid suggest one time saliva sampl replac subgingiv plaqu microbi analysi red complex bacteria periodont patient given posit microbi associ saliva subgingiv plaqu thorough review longitudin clinic studi need assess role saliva | D010518;D012463 | T047;T031 |
34,692,560 | analysi risk factor carbapenem resist klebsiella pneumonia infect effect outcom earli infect kidney transplant infect remain major caus morbid mortal kidney transplant kt recipi studi perform identifi overal preval earli infect preval carbapenem resist klebsiella pneumonia crkp infect kt one year postop mortal patient earli infect risk factor crkp infect | D016030;D007710 | T047;T061 |
34,692,559 | sex matter effect sex mate presenc absenc protect microb anim femal invest offspr product greater male lifetim reproduct success lrs predict optim femal extend lifespan maxim reproduct event increas invest immun male howev maxim lifetim reproduct success obtain mani mate possibl popul consist main hermaphrodit optim reproduct success may primarili influenc gamet resourc avail microb mediat protect mmp known affect immun reproduct whether sex influenc respons mmp remain explor investig sex specif differ surviv behavior time offspr product femin hermaphrodit femal male caenorhabd elegan follow pathogen infect staphylococcus aureus without mmp enterococcus faecali overal femal surviv decreas increas mate mmp femal increas invest offspr product male display higher behavior activ mmp furthermor abl dampen cost femal experi due mate male result demonstr strategi employ pathogen infect without mmp sex depend | D017173;D012098 | T040;T204;T079;T081 |
34,692,558 | network interact gut microbiom host biomark urin metabolom carotid atherosclerosi comprehens analys multi omic data may provid insight interact differ biolog layer concern distinct clinic featur integr data gut microbiota blood paramet urin metabolit treatment naiv individu present wide rang metabol diseas phenotyp delin clinic meaning associ tran omic correl network reveal candid gut microbi biomark urin metabolit featur covari distinct clinic phenotyp integr gut microbiom urin metabolom phenom reveal variat one three system correl chang two specif note clinic paramet liver function identifi eubacteriumeligen faecalibacteriumprausnitzii ruminococcuslactari associ healthi liver function wherea clostridium boltea tyzzerellanexil ruminococcusgnavus blautiahansenii atopobiumparvulum associ blood biomark liver diseas variat microbiota featur parallel chang specif urin metabolit network model yield two core cluster includ one larg gut microb urin metabolit close knit cluster one triangular cluster compos gut microb blood urin network demonstr close inter system crosstalk especi gut microbiom urin metabolom distinct clinic phenotyp manifest gut microbiom urin metabolom inter domain connect take form high dimension network network may understand complex biolog system may provid basi identifi biomark diseas deciph complex human physiolog diseas requir holist tran omic approach integr multi layer data set includ gut microbiom profil biolog fluid studi gut microbiom carotid atherosclerosi identifi microbi featur associ clinic paramet observ group urin metabolit correl group clinic paramet combin three data set reveal correl entiti across three system suggest physiolog chang reflect omic find provid insight interact network gut microbiom blood clinic paramet urin metabolom concern physiolog variat show promis tran omic studi biomark discoveri | D002340;D000069196 | T007;T047;T001 |
34,692,427 | hiv preval map use small area estim kenya tanzania mozambiqu first sub nation level local estim hiv preval provid inform use target intervent consequ increas effici resourc enhanc alloc lead better health outcom includ control diseas spread peopl | D015658 | T047 |
34,692,394 | associ hypertens diabet ischem heart diseas stroke mortal india million death studi cardiovascular outcom hypertens diabet india never studi nation level | D003920;D006973;D017202;D020521 | T047 |
34,692,393 | altern low molecular weight heparin anticoagul pregnant women mechan heart valv middl incom countri cohort studi compar cardiac complic pregnanc outcom women mechan heart valv mhvs two differ anticoagul regimen middl incom countri | D011249;D047928 | T047;T046 |
34,692,392 | h ambulatori blood pressur monitor sub saharan africa hypertens phenotyp dip pattern malawian hiv patient antiretrovir therapi cardiovascular diseas especi hypertens grow problem among peopl live hiv plhiv antiretrovir therapi art sub saharan africa | D015658;D006973 | T047 |
34,692,391 | prevent next pandem case invest circulatori health global coalit circulatori health posit paper coronavirus diseas covid continu robust impact world health result covid pandem devast physic mental fiscal impact million peopl live noncommunic diseas ncds addit older age peopl live cvd stroke obes diabet kidney diseas hypertens particular greater risk sever form covid consequ meta analysi indic hypertens diabet chronic kidney diseas thrombot complic observ preval danger co morbid covid patient despit near incalcul physic mental emot econom toll pandem forthcom public health figur continu place cardiovascular diseas number one caus death across globe year world simpli wait next pandem invest ncds social determin health address healthcar system holist multisector approach basi sustain develop goal sdgs need truli address social econom inequ build resili system yet reason hope un polit declar uhc provid strong framework build resili health system explicit call invest ncds refer fiscal polici put invest firm within reach cement import address circulatori health futur framework convent emerg prepared member state take concret step toward pandem free futur chief repres global circulatori health communiti patient global coalit circulatori health call increas support healthcar workforc global vaccin equiti embrac new model care digit health solut well fiscal polici unhealthi commod support invest | D000086382;D000073296 | T047;T067 |
34,692,390 | evalu qatar first cardiac rehabilit program brief report studi impact cardiac rehabilit cr eastern mediterranean region emr burden risk factor context somewhat differ western countri much evid deriv | D000072038 | T061 |
34,692,389 | complet revascular surviv stemi complet revascular cr st elev myocardi infarct patient multivessel coronari arteri diseas mvd proven better regard combin endpoint incomplet revascular ir recent random control trial impact surviv | D003324;D062645;D000072657 | T047;T061 |
34,692,388 | present manag hospit outcom patient acut heart failur south india sex secondari analysi prospect interrupt time seri studi sex differ present manag outcom heart failur hf observ uncertain whether differ exist south india | D006333 | T047;T046 |
34,692,387 | world heart feder roadmap hypertens updat world heart feder whf roadmap seri cover larg rang cardiovascular condit roadmap identifi potenti roadblock solut improv prevent detect manag cardiovascular diseas provid generic global framework avail local adapt first roadmap rais blood pressur publish sinc advanc hypertens includ public new clinic guidelin ahaacc esc eshish launch global heart initi associ resolv save live rtsl initi inclus singl pill combin essenti medicin list well various advanc technolog particular telemedicin mobil health given substanti benefit accru effect intervent manag hypertens potenti scalabl low middl incom countri lmic whf revisit updat roadmap rais bp roadmap hypertens incorpor new develop scienc polici even though cost effect lifestyl medic intervent prevent manag hypertens exist uptak still low particular resourc poor area roadmap examin roadblock pertain demand side demograph socio econom factor knowledg belief social relat norm tradit suppli side health system resourc process along patient pathway propos rang possibl solut overcom includ develop popul wide prevent control programm implement opportunist screen offic blood pressur measur strengthen primari care greater focus task share team base care deliveri peopl centr care stronger patient carer educ facilit adher treatment depend upon avail effect distribut good qualiti evid base inexpens bp lower agent | D002318;D006973 | T047 |
34,692,386 | persist hypertens one year postpartum among women hypertens disord pregnanc low resourc set prospect cohort studi hypertens disord pregnanc hdps associ lifelong cardiovascular diseas risk persist postpartum hypertens hdps could suggest progress chronic hypertens phenomenon well examin low middl incom countri limc previous follow up typic last maxim six week postpartum assess preval persist hypertens one year women hdps low resourc set determin associ risk factor | D046110;D011225 | T047;T046 |
34,692,385 | clean air smart citi healthi heart action air pollut cardiovascular health twenti percent cardiovascular diseas cvd death caus air pollut three million death everi year number continu rise unless global communiti take action nine ten peopl worldwid breath pollut air disproportion affect live low resourc set world heart feder whf commit reduc impact air pollut peopl health made prioriti area global advocaci effort pursuit goal whf form air pollut expert group inform action air pollut cvd health recommend chang public health polici polici paper lay health impact air pollut examin posit global polici agenda demonstr relev cardiovascular communiti propos action polici measur mitig dead risk factor health paper consid import role play member whf includ scientif societi physician constitut heart health foundat patient advocaci group paper conclud detail tabl recommend various sub target group global nation local patient level | D000397;D002318 | T080;T069;T047 |
34,692,384 | call emerg action limit global temperatur increas restor biodivers protect health wealthi nation must much much faster joint editori call emerg action limit global temperatur increas restor biodivers protect health | D044822;D004636 | T080;T093;T073 |
34,692,383 | patient center sustain hypertens care case adopt differenti servic deliveri model hypertens servic low middl incom countri expand hypertens servic low middl incom countri requir effici effect servic deliveri approach meet need expect peopl live hypertens within resourc constraint exist nation health system ideal hypertens program extend treatment coverag maintain servic qualiti maxim effici resourc util improv clinic outcom articl discuss lesson learn hiv differenti servic deliveri initi make case approach adopt hypertens program | D015658;D006973 | T047 |
34,692,382 | develop non laboratori cardiovascular risk assess chart valid laboratori non laboratori base model develop simplifi risk assess model base non laboratori risk factor could determin cardiovascular risk accur laboratori base one valuabl particular develop countri limit resourc | D002318 | T047 |
34,692,381 | incid predictor outcom contrast induc nephropathi patient st elev myocardi infarct undergo primari percutan coronari intervent contrast induc nephropathi cin consid one common caus hospit acquir renal failur sever affect morbid mortal object investig incid predictor outcom cin patient st elev myocardi infarct stemi undergo primari percutan coronari intervent ppci | D007674;D062645;D000072657 | T047;T061 |
34,692,380 | circul microrna biomark acceler sarcopenia chronic heart failur sarcopenia critic find patient chronic heart failur chf howev search definit biomark predict muscl function declin chf remain elus | D000074166;D006333;D035683;D055948 | T123;T047;T114;T046 |
34,692,376 | effect nanosecond puls electr field cell vital apoptosi prolifer tpc cell evalu effect nanosecond puls electr field nspef differ puls durat cell vital apoptosi prolifer tpc cell optim puls paramet expand applic rang nspef | D000077273;D013964 | T191 |
34,692,231 | rhabdomyolysi associ sever levodopa induc dyskinesia parkinson diseas report two case literatur review rhabdomyolysi associ levodopa induc dyskinesia rhab lid extrem rare life threaten treatabl condit patient parkinson diseas pd | D020820;D010300;D012206 | T047;T184;T046 |
34,692,230 | clinic valu patient home video movement disord numer studi shown valu patient home video record within field epilepsi despit grow influenc mobil technolog telemedicin pauciti studi examin role home video diagnosi movement disord | D004827;D009069;D017216 | T058;T033;T047 |
34,692,229 | post irradi facial neuromyotoniamyokymia hemifaci spasm mimic hemifaci spasm diagnos clinic base certain atyp featur alert physician mimic | D005155;D019569;D020386;D020385 | T033;T047;T184 |
34,691,777 | year chang adipos cameroon school age children evid increas central adipos higher adipos level tallest age children examin chang measur adipos determin preval excess adipos relat height school children | D050154;D001827 | T032 |
34,691,394 | valid wrist blood pressur measur devic omron rs hem e among obes sudanes patient accord european societi hypertens intern protocol revis background electron devic measur blood pressur bp need go independ clinic valid recommend differ author general specif popul aim studi assess valid omron rs hem e wrist oscillometr devic obes sudanes patient method obes individu invit recruit includ studi bp level wrist measur use omron rs standard mercuri sphygmomanomet two observ made mean taken bp differ two method particip classifi three categori mmhg accord european societi hypertens intern protocol revis esh ip criteria use assess valid test omron rs devic result particip mean age year standard deviat sd rang averag systol blood pressur sbp mmhg sd rang averag diastol blood pressur dbp mmhg sd rang good agreement two observ use omron rs standard sphygmomanomet mmhg sbp mmhg dbp mean differ mmhg sbp mmhg dbp conclus thus omron rs hem e valid suitabl measur bp accord esh ip | D006973;D014953 | T047;T029 |
34,691,393 | potenti lunasin extract prevent breast cancer progress upregul e cadherin inhibit icam background research natur substanc anticanc potenti becom increas popular lunasin soybean protein known inhibit cancer progress via various pathway aim studi investig effect lunasin extract le express intercellular adhes molecul icam epitheli cadherin e cadherin breast cancer method true experiment vivo studi spragu dawley rat induc dimethylbenz anthracen dmba use base therapi given group divid normal posit control pc negat control nc adjuv curat prevent lunasin extract soybean seed grobogan varieti indonesia tissu sampl obtain process stain anti icam anti e cadherin antibodi examin microscop quantifi use h score data analyz use anova follow duncan test result statist signific differ icam express observ follow group adjuv nc normal nc pc nc adjuv prevent normal prevent pc prevent adjuv curat normal curat pc curat e cadherin express signific differ prevent nc adjuv nc pc nc normal nc adjuv curat pc curat normal curat normal prevent signific negat correl found icam e cadherin p conclus prevent dose le abl reduc icam express increas e cadherin express | D018799;D009369 | T129;T191;T116 |
34,691,381 | therapeut effect analysi plasma bipolar intellig electroton cystostomi treatment senil prostat hyperplasia solv prostat hyperplasia elder method cystostomi plasma bipolar resect propos januari march patient bph need surgic treatment urolog depart select cystostomi perform bipolar turp cystostomi group robot group divid two group surgic safeti surgic effici complic nurs time two group compar result show experiment control group ruv valu signific lower surgeri comparison qmax valu consider higher surgeri differ statist signific p suggest cystostomi group bipolar turp substanti improv dysuria better recoveri detrusor function better prognosi prove bph g cystostomi could reduc oper time bladder irrig time cathet indwel time postop hospit stay improv oper effici effect patient symptom improv excel psycholog support higher qualiti life score prove plasma bipolar resect combin cystostomi effect improv annual bph surgeri | D011470;D020728 | T191;T047;T061 |
34,691,380 | sport enterpris market financi risk manag base decis tree data mine develop modern economi tradit sport industri enterpris also develop financi busi ensur inform secur financi risk manag problem face sport compani risk assess use mathemat model calcul risk factor establish previous step predict possibl risk respons problem develop sport enterpris market financi risk manag model base decis tree data mine first establish relev evalu index system data sampl depth understand actual market financi problem sport compani second use decis tree algorithm mine explor relat data sampl conduct risk assess relat indic use model calcul probabl occurr risk analyz degre damag final algorithm paper analyz discuss simul experi | D057225;D040541 | T066;T057 |
34,691,379 | influenc factor gastrointestin function recoveri gastrointestin malign tumor gastric cancer malign tumor high incid world incid rate increas everi year loss mental properti caus surgeri postop recoveri treatment becom difficult problem mani famili solv explor factor affect recoveri gastrointestin function surgeri acceler recoveri becom one import research topic current medic expert scholar purpos articl explor factor affect recoveri gastrointestin function gastrointestin malign paper first experiment investig fast time oper method patient undergo gastrointestin malign tumor surgeri use variabl conduct control experi first defec time exhaust time bowel sound recoveri experiment subject surgeri record chang time indic compar verifi whether affect recoveri gastrointestin function experiment data show recoveri time bowel sound h patient fast time less equal day oper time first exhaust h time first defec h recoveri time bowel sound patient fast time longer day h first exhaust time h first defec time h therefor resum diet soon possibl oper benefici recoveri gastrointestin function patient gastrointestin malign | D013274 | T191 |
34,691,378 | adapt diagnosi lung cancer deep learn classif use wilcoxon gain generat cancer complic worldwid health issu increas death rate recent year swift bloom high throughput technolog sever machin learn method unfold recent year progress cancer diseas diagnosi made base subset featur provid awar effici precis diseas diagnosi henc progress machin learn techniqu fortun differenti lung cancer patient healthi person great concern paper propos novel wilcoxon sign rank gain preprocess combin generat deep learn call wilcoxon sign generat deep learn ws gdl method lung cancer diseas diagnosi first test signific analysi inform gain elimin redund irrelev attribut extract mani inform signific attribut use generat function generat deep learn method use learn deep featur final minimax game ie minim error maximum accuraci propos diagnos diseas numer experi thorac surgeri data set use test ws gdl method diseas diagnosi perform ws gdl approach may creat relev signific attribut adapt diagnos diseas select optim learn model paramet quantit experiment result show ws gdl method achiev better diagnosi perform higher comput effici comput time comput complex fals posit rate compar state art approach | D000077321;D008175 | T191;T066 |
34,691,377 | regress analysi factor base cluster analysi acut radiat pneumonia due radiat therapi lung cancer conduct paper regress analysi factor associ acut radiat pneumonia due radiat therapi lung cancer util cluster analysi explor predict effect clinic dosimetri factor grade radiat pneumonia due radiat therapi lung cancer refin effect ratio volum primari foci volum lung lobe locat radiat pneumonia refin factor clinic effect predict occurr grade radiat pneumonia provid basi better guid lung cancer radiat therapi reduc occurr grade radiat pneumonia improv safeti radiotherapi base characterist select surveil data experiment simul factor acut radiat pneumonia due lung cancer radiat therapi perform base three signal detect method use fuzzi mean cluster algorithm drug name target advers drug reaction characterist drug classifi three categori method design use determin classif correct evalu function best signal detect method factor classif risk featur identif acut radiat pneumonia due radiat therapi lung cancer base adr achiev use cluster analysi featur extract techniqu provid referenc method establish factor classif mechan acut radiat pneumonia due radiat therapi lung cancer new idea reus adr surveil report data resourc | D008175;D011014;D017564 | T191;T047;T050;T037 |
34,691,376 | analysi risk factor neurobiolog pipelin care investig prevent measur clinic care neurosurg patient critic ill sudden onset ill treat time proper care patient requir continu hospit proper treatment recoveri patient may relat slow take time patient method explor risk pipelin care lie prevent measur paper neurosurg patient treat hospit septemb march first select divid two group group implement routin pipelin care group b implement intervent develop pipelin team design smote assum generat new synthet sampl minor class immedi neighbor minor class instanc also minor class regardless true distribut characterist analyz risk factor care summar prevent measur result experiment result show total effici nurs care higher group b compar group p also number pipelin accid lower group b conclus import meticul thought pipelin care comprehens analyz possibl risk event propos prevent measur risk event reduc | D016638;D006760 | T058;T047 |
34,691,375 | stressor nurs intern influenc factor cross section studi still unknown whether stress level stressor chines nurs intern influenc teacher relat factor research carri better understand stress nurs intern distribut stressor clinic practic target measur unwind stress nurs intern | D007396 | T097;T065 |
34,691,374 | imag recognit framework oral cancer cell oral squamous cell carcinoma oscc common type cancer oral caviti despit great impact mortal suffici screen techniqu earli diagnosi oscc often lack accuraci thus oscc most diagnos late stage earli detect accur recognit oscc would lead improv curat result reduct recurr rate surgic treatment introduct imag recognit technolog doctor diagnosi process signific improv cancer diagnosi reduc individu differ effect assist doctor make correct diagnosi diseas object studi assess precis robust deep learn base method automat identifi extent cancer digit oral imag present new method employ differ variant convolut neural network cnn detect cancer oral cell approach involv train classifi differ imag imagenet dataset independ valid differ cancer cell imag segment use multiscal morpholog method prepar cell featur analysi extract method morpholog edg detect use accur extract target cell area perimet multidimension featur follow classif cnn five variant cnn name vgg vgg inceptionv inceptionresnetv xception train valu loss less experiment result show method effect tool oscc diagnosi | D002294;D009062 | T191 |
34,691,373 | intellig solut chest abnorm detect base yolov resnet comput aid diagnosi cad near fifti year histori assist mani clinician diagnosi develop technolog recent research use deep learn method get high accuraci result cad system cad comput output use second choic radiologist contribut doctor final right decis chest abnorm detect classic detect classif problem research need classifi common thorac lung diseas local critic find detect problem two deep learn method one stage method two stage method paper introduc analyz repres model rcnn ssd yolo seri order better solv problem chest abnorm detect propos new model base yolov resnet yolov latest yolo seri flexibl one stage detect algorithm function yolov paper local abnorm region hand use resnet avoid gradient explos problem deep learn classif filter result got yolov resnet resnet recogn imag abnorm yolov detect result discard dataset collect via vinbigdata web base platform vinlab train model dataset use pytorch frame use map precis f score metric evalu model perform progress experi method achiev superior perform classic approach dataset experi show yolov map higher yolov fast rcnn efficientdet addit dimens precis model also perform better model precis model higher yolov fast rcnn efficientdet | D000077321 | T066 |
34,691,372 | intracavitari electrocardiogram guidanc aid excav rhythm abnorm patient occult heart diseas paper analysi intracavitari electrocardiogram use guid mine abnorm cardiac rhythm patient hidden heart diseas algorithm improv address data imbal problem exist abnorm electrocardiogram signal weight base automat classif algorithm deep convolut neural network electrocardiogram signal propos preprocess electrocardiogram data mit bih arrhythmia databas experiment dataset train algorithm model obtain algorithm model migrat project term system design implement compar advantag disadvantag electrocardiogram monitor system platform overal design system carri term function perform requir accord system realize goal mobil platform system capabl classifi common abnorm electrocardiogram signal develop system capabl long term monitor invok automat classif algorithm model electrocardiogram signal analysi paper function logic test perform test conduct main function modul system test result show system run stabli monitor electrocardiogram signal long time correct call deep convolut neural network base automat electrocardiogram signal classif algorithm analyz electrocardiogram signal achiev requir display electrocardiogram signal waveform analyz heartbeat type calcul averag heart rate achiev goal real time continu monitor analysi electrocardiogram signal | D006331;D012815 | T047;T066 |
34,691,371 | analysi clinic effect music combin hypnosi labor analgesia base data mine object paper studi curat effect music combin hypnosi labor pain childbirth base algorithm data mine random select women deliv babi obstetr unit octob june set control group observ group obtain relev clinic data comparison analyz valu music combin hypnot analgesia midwiferi obstetr result show number spontan deliveri case observ group higher control group p deliveri time observ group better control group p prove music combin hypnosi effect improv rate natur childbirth shorten overal labor time guarante health mother child | D000698;D006990;D007743;D009146 | T040;T170;T061 |
34,691,370 | sex differ post traumat stress disord high advers cohort south african adolesc examin depress symptom age trauma type explanatori factor evid high incom countri hic document higher rate post traumat stress disord ptsd femal male howev data limit sex differ ptsd low middl incom countri lmic despit particular high level trauma experienc lmic youth | D008016 | T079;T067 |
34,691,369 | constraint liberti movement attach style signific account well three palestinian sampl polit violenc constraint liberti movement consequ health well affect individu differ | D018912;D059026;D005610;D009769 | T080;T041;T098;T078 |
34,691,368 | role prison offic regul inmat affect exposur violent behaviour develop ptsd symptom interact inmat major sourc stress prison offic given conflict natur relationship violent behaviour toward prison offic uncommon pose threat psycholog well | D000080103;D007398;D011330 | T073;T055;T041;T054;T080 |
34,691,356 | role human nadph quinon oxidoreductas nqo oxygen mediat cellular injuri oxid dna damag human pulmonari cell supplement oxygen administr frequent use prematur infant adult pulmonari insuffici nadph quinon oxidoreductas nqo protect cell oxid injuri decreas reactiv oxygen speci ros investig test hypothesi overexpress nqo bea b cell mitig cell injuri oxid dna damag caus hyperoxia c singl nucleotid polymorph snp nqo promot would display alter suscept hyperoxia mediat toxic use stabl transfect bea b cell demonstr hyperoxia decreas cell viabil control cell ctr effect differenti mitig cell overexpress nqo regul cmv viral promot wild type nqo promot nqo nqo nqo promot carri snp interest hyperoxia decreas format bulki oxid dna adduct hydroxi deoxyguanosin ohdg ctr cell qpcr studi show mrna level cypa nqo invers relat dna adduct format suggest protect role enzym oxid dna injuri sirna experi entail nqo nqo promot hyperoxia caus decreas cell viabil effect potenti cell treat cypa sirna also found hyperoxia caus mark induct dna repair gene ddb xpc ctr cell support idea hyperoxia part caus attenu bulki oxid dna lesion enhanc nucleotid excis repair ner pathway summari data support protect role human nqo oxygen mediat toxic oxid dna lesion human pulmonari cell protect toxic partial lost snp cell moreov also demonstr novel protect role cypa attenu oxid cell dna injuri futur studi mechan attenu oxid injuri nqo help develop novel approach preventiontreat ard human | D018384 | T049 |
34,691,317 | efficaci moxibust serum level cxcl ep patient rheumatoid arthriti studi aim evalu efficaci moxibust joint swell pain level c x c motif chemokin ligand cxcl endorphin ep serum rheumatoid arthriti ra patient investig anti inflammatori analges mechan moxibust improv ra | D001172;D009071 | T047;T061 |
34,691,315 | role emphysema index combin chronic obstruct pulmonari diseas assess test score evalu chronic obstruct pulmonari diseas studi aim evalu efficaci emphysema index ei distinguish chronic bronchiti cb chronic obstruct pulmonari diseas copd role combin copd assess test cat score evalu copd | D004646;D029424;D011656 | T047;T046 |
34,691,290 | retrospect cohort studi associ red cell distribut width caus mortal patient cholecyst icu admiss elev red cell distribut width rdw report associ mortal critic ill patient popul aim articl investig relationship rdw hospit mortal short long term mortal patient cholecyst | D004909 | T033;T034;T059;T081 |
34,691,286 | diagnost prognost predict monitor role neutrophil cdb monocyt cd neonat sepsi sepsi critic medic condit requir addit diagnost consider recent focus shift diagnosi sepsi use new marker overcom limit tradit laboratori diagnost modal neutrophil cdb ncdb monocytecd mcd cell surfac antigen shown use diagnost consider | D009000;D009504 | T025 |
34,691,283 | associ congenit cytomegalovirus infect brain injuri neonat meta analysi cohort studi assess associ congenit cytomegalovirus cmv infect brain injuri neonat | D001930;D003586;D006319 | T047;T037 |
34,691,282 | first h hemodynam manag nicu revascular surgeri moyamoya diseas evalu whether hemodynam factor risk factor prognosi moyamoya diseas mmd | D002548;D009072 | T047;T061 |
34,691,241 | spatial predict covid china base machin learn algorithm geograph weight regress covid swept world sinc decemb caus larg number patient death spatial predict spread epidem great import diseas control manag studi predict cumul confirm case cccs jan mar mainland china citi level use machin learn algorithm geograph weight regress gwr partial least squar regress plsr base popul flow geoloc meteorolog socioeconom variabl valid result show machin learn algorithm gwr achiev good perform model could effect predict cccs wuhan first citi report covid case china perform well citi random forest rf outperform method cv r model popul flow wuhan citi wp import featur featur also made consider contribut predict accuraci compar rf gwr show slight wors perform cv r requir fewer spatial independ variabl studi explor spatial predict epidem base multisourc spatial independ variabl provid refer estim cccs region lack accur time | D005843;D000069550 | T066;T077;T090 |
34,691,240 | long term effect left atrial appendag occlus treat patient previous ischem stroke diseas recurr total patient admit tangdu hospit juli septemb group control group n observ group n patient control group treat thrombolyt anticoagul observ group treat drug laao transesophag echocardiographi tee perform observ occlus laa patient observ group month respect clinic outcom two group compar follow aspect recurr incid system embol year recurr free surviv rfs year recurr patient compar fisher exact test | D055989 | T074 |
34,691,237 | genet algorithm data mine colorect imag current effect analyt method colorect imag analysi lead certain error colorect imag analysi order improv accuraci colorect imag detect studi use genet algorithm data mine algorithm combin imag process technolog perform imag analysi time combin actual requir imag detect gray theori model use basic theori imag process imag detect predict model construct predict data addit order studi effect algorithm experi carri analyz valid data studi predict valu compar actual valu research show propos algorithm certain accuraci provid theoret refer subsequ relat research | D000465 | T170 |
34,691,236 | sentiment analysi base nurs note hospit day mortal sepsi patient util mimic iii databas medic visual nurs note contain rich inform patient patholog condit howev wide use predict clinic outcom advanc process natur languag inform begin extract larg scale unstructur data like nurs note studi extract sentiment inform nurs note explor associ hospit day mortal sepsi patient data patient nurs note extract mimic iii databas cox proport hazard model use analyz relationship sentiment score nurs note hospit day mortal base cox model individu prognost index pi calcul surviv analyz among elig sepsi patient case suffer hospit day mortal dead group surviv surviv group signific differ shown two group sentiment polar simplifi acut physiolog score ii sap ii score age intens care unit icu type p multivari cox analysi exhibit sentiment polar hr ci p sentiment subject hr ci p invers associ hospit day mortal sap ii score hr ci p posit correl hospit day mortal median death time patient pi signific earlier patient pi vs day p conclus sentiment nurs note associ hospit day mortal surviv sepsi patient | D000090042 | T066 |
34,691,195 | high seropreval sar cov covid specif antibodi among healthcar worker cross section studi guilan iran studi conduct evalu anti sar cov igm igg antibodi among healthcar worker guilan | D000914;D000086382;D006282;D000086402 | T116;T047;T097;T129;T005;T067 |
34,691,173 | multitask learn model multiperspect attent applic recommend train model predict click order target time better user satisfact busi effect multitask learn one import method e commerc exist research model user represent base histor behaviour sequenc captur user interest often case user interest may chang past routin howev multi perspect attent broad horizon cover differ characterist human reason emot percept attent memori paper attempt introduc multi perspect attent sequenc behaviour multitask learn propos method offer better understand user interest decis achiev flexibl paramet share maintain special featur advantag task improv attent mechan view expert interact best knowledg first propos implicit interact mode explicit hard interact mode explicit soft interact mode data fusion mode multitask learn experi public data lab medic data result show model consist achiev remark improv state art method | D007858;D000069550 | T061;T062;T066;T041 |
34,691,172 | session recommend model base context awar gate graph neural network graph neural network gnn base approach success appli session base recommend task howev face complex chang real world situat exist session recommend algorithm fulli consid context inform user decis make furthermor import context inform behavior model wide recogn base paper present session recommend model base context awar gate graph neural network ca ggnns first paper present session sequenc data graph structur second embed vector represent item session graph obtain use gate graph neural network ggnn paper gru ggnn expand replac input matrix state matrix convent gru input context captur session eg time locat holiday interv context repres proport total session time item session final soft attent mechan use captur user interest prefer recommend list given ca ggnn model combin session sequenc inform context inform time result open yoochoos diginetica dataset show model signific improv compar latest session recommend method | D000465;D016571 | T170 |
34,691,171 | research volleybal video intellig descript technolog combin long term short term memori network attent mechan develop comput technolog video descript combin key technolog field natur languag process comput vision attract research attent among object effici describ high speed detail sport video key develop video descript field view problem sentenc error loss visual inform generat video descript text due lack languag learn inform exist video descript method multihead model combin long term short term memori network attent mechan propos intellig descript volleybal video introduct attent mechan model pay much attent signific area video generat sentenc compar experi differ model result show model attent mechan effect solv loss visual inform compar lstm base model multihead model propos paper combin long term short term memori network attent mechan higher score evalu index signific improv qualiti intellig text descript volleybal video | D016571;D054798 | T170;T056 |
34,691,170 | chines languag featur analysi base multilay self organ neural network data mine techniqu one oldest languag world chines long cultur histori uniqu languag charm multilay self organ neural network data mine techniqu wide use achiev high precis predict differ field howev hard appli chines languag featur analysi order accur analyz characterist chines languag paper use multilay self organ neural network correspond data mine technolog featur recognit compar differ type neural network algorithm result show multilay self organ neural network make accuraci recal f score featur recognit reach respect mani sampl influenc strong nois keep high effici featur analysi show multilay self organ neural network superior perform provid strong support chines languag featur analysi | D007802;D016571 | T171;T170 |
34,691,169 | method short term predict metro station individu energi consumpt item base g aco bp model paper propos new method make short term predict three kind primari energi consumpt power light ventil air condit metro station first paper extract five main factor influenc metro station energi consumpt kernel princip compon analysi kpca second improv genet ant coloni optim g aco fuse bp neural network train optim connect weight threshold bp neural network layer paper build g aco bp neural model make short term predict differ energi consumpt metro station predict energi consum power light ventil air condit experiment result show g aco bp neural model could give accur effect predict main energi consumpt metro station | D016571 | T170 |
34,691,168 | smart surveil system uncoop gait recognit use cycl consist generat adversari network ccgan surveil remain import research area mani applic smart surveil requir high level accuraci even person uncoop gait recognit studi recogn peopl way walk even unwil cooper anoth form behavior biometr system uniqu attribut individu gait analyz determin ident hand one big limit gait recognit system uncoop environ galleri probe set made differ unknown walk condit order tackl problem propos deep learn base method train individu normal walk condit deal uncoop environ recogn individu dynam walk condit cycl consist generat adversari network use method translat gei disturb differ covari factor normal gei work like unsupervis learn train gei disrupt differ covari factor individu act sourc domain normal walk condit individu target domain translat requir cycl consist gan automat find individu pair help cycl loss function generat requir gei test cnn model predict person id propos system evalu public avail data set name casia b achiev excel result moreov system implement sensit area like bank seminar hall event airport embassi shop mall polic station militari area public servic area secur purpos | D007091;D010363 | T066;T041 |
34,691,167 | intern trade path multi polar base multidirect mutat genet algorithm enabl neural network present develop speed intern trade catch econom develop speed insuffici develop speed intern trade direct affect rapid develop nation economi order solv problem intern trade overal optim schedul trade vehicl optim plan trade transport path import improv enterpris servic reduc enterpris cost increas enterpris benefit enhanc enterpris competit second develop program base program interfac provid baidu map paper propos neural network algorithm genet optim multipl mutat overcom shortcom tradit genet algorithm popul ten charact distribut mix multipl code method enhanc local search abil genet algorithm introduc new larg mutat small rang search popul exampl applic show optim method realiz optim intern trade path real road condit great improv work effici actual trade | D003132;D038622 | T057;T064;T097;T078;T067;T081 |
34,691,166 | improv ecg deriv respir use empir wavelet transform kernel princip compon analysi mani method develop deriv respir signal electrocardiogram ecg howev tradit method two main issu focus certain specif morpholog characterist consid nonlinear relationship ecg respir paper improv ecg deriv respir edr base empir wavelet transform ewt kernel princip compon analysi kpca propos tackl first problem ewt introduc decompos ecg signal extract low frequenc part tackl second issu kpca preimag introduc captur nonlinear relationship ecg respir paramet select radial basi function kernel kpca also improv ensur accuraci reduct comput cost correl coeffici amplitud squar coher coeffici use metric carri quantit qualit comparison three tradit edr algorithm result show propos method perform better tradit edr algorithm obtain singl lead edr signal | D004562;D058067 | T062;T074;T060 |
34,691,165 | method detect incipi fault satellit base dynam linear discrimin analysi time detect treatment possibl incipi fault satellit effect reduc damag harm could caus although much work done concern fault detect problem relat question satellit incipi fault littl address paper new satellit incipi fault detect method propos combin idea deviat unsupervis fault detect method classif supervis fault detect method first propos method use dynam linear discrimin analysi lda find optim project vector separ orbit data normal histor data much possibl second assumpt paramet obey multidimension gaussian distribut appli normal histor data optim project vector build normal model final employ noncentr f distribut test whether fault occur propos method valid use numer simul case real satellit fault case result show method propos paper effect detect incipi fault tradit method | D000465 | T170 |
34,691,079 | dynam lymphocyt activ relat paradox tuberculosi associ immun reconstitut inflammatori syndrom person advanc hiv person live hiv plwh experi signific restor immun associ success inhibit viral replic antiretrovir therapi art initi nevertheless robust quantit qualit restor cd lymphocyt fraction patient co infect tuberculosi develop immun reconstitut inflammatori syndrom tb iri dysregul inflammatori respons associ signific tissu damag sever studi underscor role adapt immun cell iri pathogenesi degre lymphocyt activ contribut tb iri develop remain larg elus sought dissect phenotyp landscap lymphocyt activ plwh coinfect tb initit art focus character profil link develop tb iri confirm previous observ demonstr tb iri individu display pronounc cd lymphopenia prior art initi addit found art induc increas lymphocyt activ prolifer cytotox among tb iri patient import demonstr tb iri subject display higher frequenc cytotox cd lymphocyt affect art moreov patient exhibit higher level activ hla dr profil ki cd cell art commencen non iri counterpart network analysi reveal signific negat correl total cd cell count frequenc cytotox cd cell studi popul could suggest exist compensatori mechan mtb infect cell elimin face sever cd cell lymphopenia also investig correl lymphocyt activ profil abund sever inflammatori molecul plasma appli unsupervis machin learn techniqu predict diagnos tb iri art analys suggest cd cell activ marker good tb iri predictor wherea combin cd cd cell marker better diagnos tb iri patient iri event overal find contribut refin understand immunolog mechan tb iri pathogenesi may assist new diagnost tool target patient manag | D008213 | T043 |
34,691,078 | function effect receptor bind domain mutat sar cov b p variant recent identif rise domin p b sar cov variant brought intern concern may confer fit advantag three posit receptor bind domain rbd affect variant substitut differ ekni co evolv converg evolut character function immun evas consequ p b rbd mutat ek ny result gain function two differ outcom ny confer ten fold affin increas toward ace modest antibodi evas potenti plasma convalesc vaccin individu wherea ek display signific antibodi evas capac without major impact affin hand two differ substitut sever impair rbdace affin combin p b rbd variant effect part counterbalanc effect ek ny result suggest combin three mutat two step forward one step back term viral fit | D000086663;D020125;D000086402;D064370;D014611 | T116;T045;T123;T005;T061;T200 |
34,691,074 | similar differ acut phase respons sar cov rhesus macaqu african green monkey understand sar cov immun patholog critic develop effect vaccin treatment employ unbias serial whole blood transcriptom profil weight gene network correl analysi wgcna pre specifi timepoint infect understand sar cov relat immun alter cohort rhesus macaqu rms african green monkey agm present vari degre pulmonari patholog found bulk transcript chang occur day post infect normal pre infect level week evid coordin transcript network blood defin wgcna nasopharyng sar cov burden well absolut monocyt count pathway analysi gene modul reveal promin regul type type ii interferon stimul gene isg rms agm latter speci exhibit greater breadth isg upregul notabl pathway relat neutrophil degranul enrich blood sar cov infect agm rms result elud hallmark similar well differ rm agm acut respons sar cov infect may help guid select particular nhp speci model aspect covid diseas outcom | D015550 | T043 |
34,691,073 | activ inkt cell facilit liver repair hepat ischemia reperfus injuri acceler macrophag polar macrophag polar critic liver tissu repair follow acut liver injuri howev under mechan macrophag phenotyp switch well defin invari natur killer inkt cell orchestr tissu inflamm tissu repair regul cytokin product herein examin whether inkt cell play import role liver repair hepat ischemia reperfus ir injuri affect macrophag polar end subject male cbl mice hepat ir injuri mice receiv intraperiton ip inject galactosylceramid galcer vehicl compar vehicl galcer administr result promot liver repair accompani acceler macrophag differenti increas number lyc high pro inflammatori macrophag lyc low repar macrophag inkt cell activ galcer produc interleukin il interferon ifn treatment anti il antibodi delay liver repair associ increas number lyc high macrophag decreas number lyc low macrophag treatment anti ifn antibodi promot liver repair associ reduc number lyc high macrophag chang number lyc low macrophag bone marrow deriv macrophag regul express gene relat pro inflammatori repar phenotyp co cultur activ inkt cell anti il antibodi increas level pro inflammatori macrophag relat gene decreas repar macrophag relat gene cultur macrophag anti ifn antibodi revers polar macrophag cdd defici mice show delay liver repair suppress macrophag switch compar wild type mice result suggest activ inkt cell galcer facilit liver repair hepat ir injuri il ifn mediat acceler macrophag polar therefor activ inkt cell may repres therapeut tool liver repair hepat ir injuri | D008262 | T043 |
34,691,072 | non invas antibodi assess saliva determin sar cov exposur young children saliva bodi fluid hitherto unus potenti assess sar cov antibodi specif antibodi indic past sar cov infect allow estim proport individu potenti protect immun first care character plasma sampl obtain adult control group without prior sar cov infect use certifi refer elisa simultan collect saliva sampl confirm convalesc negat individu use valid herein newli develop elisa detect sar cov igg antibodi saliva saliva elisa appli assess sar cov exposur young children n age year tbingen germani toward end first pandem year sensit specif new saliva elisa respect tbingen children sampl via respect educ institut estim sar cov antibodi preval interest preschool kid posit compar primari school children less posit children self report symptom within two month prior saliva sampl could associ exclus sar cov infect saliva elisa valid suitabl protocol enabl popul base survey sar cov antibodi use non invas sampl saliva elisa test found preval sar cov antibodi signific lower young children primari school children | D000086382;D000087124 | T047;T059;T067 |
34,691,067 | case report post car infus hbv reactiv two lymphoma patient despit entecavir prevent therapi hepat b virus hbv reactiv common complic chronic resolv hbv infect patient undergo immunosuppress chemotherapi furthermor articl publish regard risk hbv reactiv lymphoma patient receiv chimer antigen receptor car cell therapi anti hbv prophylaxi guidelin clear optim strategi avail manag patient present two case patient underw car cell cocktail therapi anti cd anti cd car car cell lymphoma patient previous histori hbv infect blood test initi admiss indic posit result hepat b surfac antigen hbsag antibodi hepat b core antigen anti hbc antibodi hepat b e antigen anti hbe serum hbv dna level undetect therefor two patient receiv entecavir antivir prophylact therapi entir treatment diagnos hbv reactiv base posit serum hbv dna test result week car cell infus liver function assay indic elev level alanin transaminas alt aspart transaminas ast combin increas level total bilirubin tbil direct bilirubin dbil subsequ receiv anti hbv treatment entecavir tenofovir result serum hbv dna copi astalt level return normal week case show risk hbv reactiv lymphoma patient car cell therapi despit entecavir prevent therapi combin treatment entecavir tenofovir may effect treatment option patient hbv reactiv | D016219 | T061 |
34,691,066 | methyltransferas defici avian flavivirus attenu due suppress viral rna translat induct higher innat immun end flavivirus genom contain type cap structur form sequenti n methyl viral methyltransferas mtase cap methyl flavivirus genom essenti structur modif ensur normal prolifer virus tembusu virus tmuv genus flavivirus causat agent duck egg drop syndrom zoonot potenti identifi vitro activ tmuv mtase determin effect k k e enzymat tetrad n methyl entir k k e motif essenti mtase activ wherea n mtase activ requir investig phenotyp singl point mutat ka da ka ea introduc tmuv replicon pcmv rep nanoluc tmuv infecti cdna clone pacyc tmuv k k e mutat reduc replic abil replicon ka ka ea virus genet stabl wherea da virus unstabl revert wt virus mutant virus replic virul impair show reduc growth attenu cytopath effect reduc mortal duck embryo molecular mechan studi show translat effici mutant virus inhibit higher host innat immun induc furthermor found translat inhibit mtase defici virus caus defect n methyl wherea absenc methyl affect viral translat taken togeth data valid debilit mechan mtase defici avian flavivirus reveal import role cap methyl viral translat prolifer escap innat immun | D012367 | T114 |
34,691,065 | cellular infiltr assess function gene set base prognost model breast cancer cancer heterogen major challeng clinic practic extent vari combin differ cell type cross talk tumor cell modul tumor microenviron tme thought respons despit recent methodolog advanc cancer reliabl robust model could effect investig heterogen direct prognosticdiagnost clinic applic remain elus | D001943;D015972 | T191;T045 |
34,691,063 | diphtheria tetanus vaccin histori associ lower odd covid hospit covid character strike larg most unexplain interindividu variat symptom sever individu remain near asymptomat other suffer sever respiratori failur previous vaccin pathogen particular tetanus may part explain variat possibl readi immun system | D014611 | T061 |
34,691,062 | speed locat matter antigen stimulus dynam control car cell respons despit success b cell malign chimer antigen receptor car cell therapi yet demonstr consist efficaci across patient tumor type particular solid tumor higher rate cell exhaust associ inferior clinic outcom follow car cell therapi preval solid tumor cell exhaust may origin persist chronic antigen stimul tumor cell resist andor evad cell mediat kill exploit car exhaust classic negat feedback model incoher feedforward loop iffl investig balanc car cell activ exhaust differ antigen present dynam built upon experiment clinic data hypothes speed anatom locat antigen stimul crucial car cell respons chronic antigen stimul well harsh tumor microenviron present multipl barrier car cell efficaci solid tumor mani therapeut strategi individu insuffici improv car respons solid tumor clear one mani barrier car cell face solid tumor combin strategi target multipl barrier hold promis improv car therapi solid tumor | D016219;D008954 | T061;T075 |
34,691,060 | determin ligand specif function plastic type interferon signal type interferon famili cytokin act cell surfac receptor induc phosphoryl subset respons regul stat famili despit share receptor differ type interferon differ function immun respons infect particular differ potenc induc anti viral anti prolif respons target cell remain fulli understood function differ aris ligand specif manner level stat phosphoryl downstream function use minim comput model type interferon signal focus interferon interferon valid model quantit experiment data identifi key determin specif function plastic type interferon signal investig differ mechan signal discrimin multipl system compon bind affin receptor express level variabl receptor intern short term negat feedback soc protein differenti receptor express play togeth ensur ligand specif level stat phosphoryl base result propos phenomenolog function map stat activ downstream anti viral anti prolif activ investig differenti signal process step downstream stat phosphoryl find negat feedback protein usp enhanc differ signal interferon via ligand depend refractori give rise function plastic interferon interferon signal explor factor control function plastic beyond type interferon signal result broad applic question signal specif function plastic signal system multipl ligand act bottleneck small number share receptor | D018448 | T170 |
34,691,055 | sarcoidosi follow hematopoiet stem cell transplant clinic characterist hla associ extrins factor genet predisposit contribut etiolog sarcoidosi converg phenotyp alter immun respons associ multisystem inflammatori granulomat tissu infiltr immunolog reconstitut hematopoiet stem cell transplant hsct may repres uniqu window pathogenesi diseas describ incid clinicopatholog featur hla associ sarcoidosi hsct singl center cohort patient togeth data previous publish case | D006680 | T129;T116 |
34,691,051 | safeti immunogen efficaci effect inactiv influenza vaccin healthi pregnant women children year evid base clinic review annual influenza vaccin often recommend pregnant women young children reduc risk sever influenza howev studi investig safeti immunogen efficaci effect influenza vaccin conduct healthi adult evid base clinic review provid updat safeti profil immunogen efficacyeffect inactiv influenza vaccin iiv healthi pregnant women children year old six electron databas search may identifi articl met elig criteria includ iiv general well toler pregnant women young children low frequenc advers event follow iiv administr howev continu vaccin safeti monitor system necessari detect rare advers event iiv generat good antibodi respons seroprotect rate iiv moder high pregnant women rang young children rang vari differ influenza typessubtyp season studi show vaccin efficacyeffect valu pregnant women young children lab confirm influenza although efficacyeffect depend studi design host factor vaccin type manufactur practic antigen matchmismatch influenza vaccin strain circul strain current evid suggest benefit iiv far outweigh potenti risk iiv recommend pregnant women young children | D000087507 | T081 |
34,691,049 | systemat review meta analysi inpati mortal associ nosocomi communiti covid expos vulner immunosuppress adult littl known mortal hospit acquir nosocomi covid infect global investig risk mortal critic care admiss hospitalis adult nosocomi covid relat adult requir hospitalis due communiti acquir infect | D006760;D016867;D007297;D000086402 | T058;T033;T005;T101 |
34,691,048 | plasma exosom enrich extracellular vesicl lactat mother type diabet contain aberr level mirna postpartum period type diabet immun driven diseas insulin produc beta cell pancreat islet langerhan becom target immun mediat destruct sever studi highlight implic circul exosom microrna mirna type diabet underlin biomark valu novel therapeut potenti recent discov exosom enrich extracellular vesicl carri alter level known novel mirna breast milk lactat mother type diabet studi aim character exosom mirna circul lactat mother without type diabet hypothes differ type diabet risk offspr group reflect circul mirna profil perform small rna sequenc exosom enrich extracellular vesicl extract plasma lactat mother around week postpartum type diabet age match control found total mirna vesicl type diabet control librari differenti express plasma mother type diabet upregul downregul use cut ab logfc fdr adjust p valu extracellular vesicl verifi nanoparticl track analysi transmiss electron microscopi immunoblot five candid mirna select base involv diabet immun modulationbeta cell function hsa mir p hsa mir p hsa mir p hsa mir p hsa mir p real time qpcr valid confirm hsa mir p hsa mir p hsa mir p hsa mir p signific upregul lactat mother type diabet compar lactat healthi mother determin possibl target gene affect pathway mirna candid comput network base analys carri targetscan mirtarbas qiagen ingenu pathway analysi pantherdb databas candid show signific associ inflammatori respons cytokin chemokin mediat signal pathway studi detect aberr level mirna within plasma extracellular vesicl lactat mother type diabet postpartum period includ mirna associ diseas pathogenesi inflammatori respons | D001942 | T040;T058;T055 |
34,691,043 | alter immunogen hemagglutinin immunogen hyperglycosyl disulfid stabil influenza virus alter glycosyl pattern surfac expos glycoprotein evad host adapt immun respons viral hemagglutinin ha particular h subtyp increas overal surfac glycosyl sinc introduct previous show modul predict n link glycosyl site h ahong kong ha identifi conserv epitop ha interfac epitop occlud nativ ha trimer like expos ha breath virion surfac antibodi direct site protect via adcc mediat mechan glycan engin strategi made otherwis subdomin epitop domin murin model ask whether cystein stabil hyperglycosyl ha trimer could revers immunodomin prevent access interfac epitop focus respons ha receptor bind site rbs analysi serum respons immun mice show redirect rbs cystein stabil result overal reduct immunogen interfac epitop thus glycan engin cystein stabil two strategi use togeth alter immunodomin pattern ha result add ration immunogen design approach use manipul immun respons develop next generat influenza vaccin | D000071497 | T038 |
34,691,042 | epstein barr virus develop vaccin immun cell therapi ebv associ diseas epstein barr virus ebv first human tumor virus discov strong implic etiolog multipl lymphoid epitheli cancer year ebv associ cancer account new case cancer caus death world wide ebv also primari caus infecti mononucleosi adolesc young adult develop countri suffer infecti mononucleosi addit ebv shown play critic role pathogenesi multipl sclerosi ebv prophylact vaccin induc neutral antibodi hold great promis prevent ebv associ diseas ebv envelop protein includ ghgl gb gp play key role ebv entri infect target cell neutral antibodi elicit protein shown prevent ebv infect target cell mark decreas ebv titer peripher blood human mice challeng lethal dose ebv recent studi demonstr immun combin ghgl gb andor gp induc mark increas synergist ebv neutral activ compar immun individu protein previous clinic trial focus gp alon partial success inclus ghgl gb vaccin formul gp repres promis approach ebv prophylact vaccin develop therapeut ebv vaccin also test clinic encourag result immun various vaccin platform express ebv latent protein ebna lmp andor lmp promot specif cd cd cytotox respons anti tumor activ addit ebv envelop protein ghgl gb gp potenti increas efficaci therapeut ebv vaccin immun system play critic role control tumor immun cell therapi emerg promis treatment cancer adopt cell therapi success use prevent treatment post transplant lymphoprolif disord chimer antigen receptor cell therapi cell receptor engin cell therapi target ebv latent protein lmp lmp andor ebna develop goal increas specif efficaci treatment ebv associ cancer | D015316;D016219;D000087506 | T062;T061 |
34,691,041 | deplet cell via induc caspas increas safeti adopt cell therapi chronic hepat b cell therapi cell direct hepat b virus hbv infect cell virus specif receptor promis therapeut approach treatment chronic hepat b hbv associ cancer due high number target cell howev side effect cytokin releas syndrom hepatotox may limit safeti safeguard mechan allow deplet transfer cell demand would thus interest mean increas confid approach studi cell generat retrovir transduct express either hbv specif chimer antigen receptor car cell receptor tcr addit either induc caspas ic herp simplex virus thymidin kinas hsv tk safeti switch real time cytotox assay use hbv replic hepatoma cell target reveal activ safeti switch stop cytotox car tcr transduc cell within less one hour vivo induct ic led strong rapid reduct transfer car cell adopt transfer aav hbv infect immun incompet mice one six hour inject ic dimer reduct car cell blood spleen liver observ therebi limit hepatotox stop cytokin secret simultan howev antivir effect car cell diminish remain car cell most non function could restimul hbsag second induct ic abl deplet cell liver conclus cell co express ic hbv specif receptor effici recogn kill hbv replic cell induct cell death via ic prove effici mean deplet transfer cell vitro vivo contain unwant hepatotox | D019264 | T061 |
34,691,038 | mechan rhinovirus immun asthma major asthma exacerb children caus rhinovirus rv posit sens singl strand rna virus picornavirus famili host develop virus defens mechan mediat upregul interferon activ signal howev virus evad immun system induc immunosuppress cytokin surfac molecul like program cell death protein pd ligand pd l immunocompet cell initi rv infect epitheli cell constitut physiolog mucos barrier upon virus entranc host cell immedi recogn viral compon like dsrna ssrna viral glycoprotein cpg dna host pattern recognit receptor prrs activ toll like receptor tlr within endosom mda rig cytosol lead product interferon ifn type antivir agent everi cell type express ifnarifnar receptor thus allow general antivir activ ifn type result inhibit viral replic infect cell prevent viral spread non infect cell among immun evas mechan virus downregul ifn type receptor well induct immunosuppress cytokin tgf tgf promot viral replic associ induct immunosuppress signatur marker lap ido pd l articl review recent advanc regul interferon type express associ rv infect asthmat immunosuppress induc virus | D057131 | T040 |
34,691,037 | nkgd engag alon suffici activ cytokin induc killer cell b provid limit coactiv cytokin induc killer cik cell ex vivo expand heterogen cell popul enrich nk phenotyp cdcd due conveni relat inexpens expans capabl togeth low incid graft versus host diseas gvhd allogen cancer patient cik cell promis candid immunotherapi well known natur killer group nkgd play import role cik cell mediat antitumor activ howev remain unclear whether engag alon suffici requir addit co stimulatori signal activ cik cell likewis role b yet identifi cik cell herein investig individu cumul contribut nkgd b activ cik cell analysi suggest nkgd b implic cik cell especi cdcd subset mediat cytotox ifn secret et conjug format degranul b nkgd alon adequ enough induc degranul ifn secret lfa activ cik cell b provid limit synergi nkgd eg lfa activ c nkgd unabl costimul cd collect conclud nkgd engag alon suffic activ cik cell therebi strengthen idea target nkgd axi promis approach improv cik cell therapi cancer patient furthermor cik cell exhibit similar classic invari natur killer inkt cell defici b stimul costimul cd nkgd addit base current data diverg receptor function cik cell nk cell assum point possibl molecular modif eg use chimer antigen receptor technolog cik cell may need custom optim maxim function potenti | D008213 | T043 |
34,691,036 | cd car cell membran bound il b cell acut lymphoblast leukemia failur cd cd car cell case report present reinfus chimer antigen receptor car cell exhibit limit efficaci efficaci extramedullari relaps remain elucid b cell acut lymphoblast leukemia b although combin il demonstr potenti enhanc antitumor activ car efficaci approach remain valid clinic | D015316;D016219 | T061 |
34,691,035 | infect multipl sclerosi world sardinia sardinia world multipl sclerosi ms inflammatori diseas central nervous system sardinia italian island one area highest global preval ms genet factor wide explor explain greater preval among popul genet makeup sardinian appear make like develop autoimmun diseas strong associ ms infect report global robust evid indic role infect ms develop concern epstein barr virus ebv anti ebv antibodi patient infect ebv associ develop ms year later featur also note sardinian patient ms mani group found increas express human endogen retrovirus herv famili patient ms role pathogenesi prognosi predict treatment respons propos herv european multi centr studi shown presenc variabl among popul rang patient higher herv express note sardinian patient ms mycobacterium avium subspeci paratuberculosi map dna antibodi map protein found associ ms sardinian patient recent associ also report japanes patient ms studi analys role infecti factor sardinian patient ms compar find report popul | D015551;D014943 | T091;T046;T078 |
34,691,034 | develop verif hypoxia immun associ prognost signatur pancreat ductal adenocarcinoma aim construct hypoxia immun associ risk score model predict prognosi patient pancreat ductal adenocarcinoma pdac unsupervis consensus cluster algorithm generat two differ hypoxia cluster screen hypoxia associ immun associ pdac differenti express gene deg pdac use pearson correl analysi base cancer genom atlas tcga genotyp tissu express project gtex dataset seven hypoxia immun associ signatur gene sa pppca semac plau il gdf nrb identifi construct risk score model use univari cox regress least absolut shrinkag select oper lasso cox regress stratifi patient high low risk group valid geo icgc cohort patient low risk group show superior overal surviv os high risk counterpart p moreov suggest multivari cox regress construct hypoxia associ immun associ prognosi signatur might use independ factor prognosi predict p cibersort estim algorithm discov patient high risk group lower immun score stromal score immun checkpoint express pd l differ immunocyt infiltr state compar low risk patient mutat spectrum also differ high low risk group sum hypoxia immun associ prognost signatur use approach stratifi risk pdac | D020869;D059467 | T086;T059;T063;T081 |
34,691,032 | autophagi induc palmit acid regul neutrophil adhes granul depend degrad integrin dairi cow fatti liver integrin critic neutrophil firm adhes tran endotheli migrat recruit inflam tissu autophagi implic cell migrat tumor metastasi facilit turnov integrin howev whether autophagi abl control neutrophil migrat promot degrad integrin unexplor show high blood level palmit acid pa strong trigger neutrophil autophagi activ lead adhes defici dairi cow fatti liver three neutrophil granul subtyp name azurophil granul ag specif granul sgs gelatinas granul ggs engulf autophagosom degrad result increas vacuol fatti liver dairi cow neutrophil import adhes associ molecul cdb cd distribut ag sgs ggs degrad three granul subtyp autophagi moreov fga hsc trim mediat degrad cytosol oxid ubiquitin cdb cd collect result demonstr high blood pa trigger neutrophil autophagi depend vacuol granul depend adhes defici decreas neutrophil mobil impair innat immun system dairi cow fatti liver theori extend categori autophagi maintain granul homeostasi provid novel strategi improv immun dairi cow metabol diseas | D001343;D002448 | T043 |
34,691,030 | identif diagnost signatur immun cell infiltr characterist rheumatoid arthriti integr bioinformat analysi machin learn strategi rheumatoid arthriti ra refer autoimmun rheumat diseas impos huge burden patient societi earli ra diagnosi critic prevent diseas progress select optim therapeut strategi effect present studi aim examin ra diagnost signatur effect immun cell infiltr patholog | D030541 | T170 |
34,691,028 | clinic imag featur patient encephalit symptom myelin oligodendrocyt glycoprotein antibodi myelin oligodendrocyt glycoprotein antibodi mog ab associ diseas mogad high heterogen clinic imag present enceph import phenotyp recent year atyp present mog ab associ enceph mog e increas report yet describ well aim studi describ clinic imag featur patient mog e center atyp phenotyp would report expect expand spectrum mogad | D015551 | T046 |
34,691,025 | nonspecif regul number immunocompet cell influenc dt toxoid children glomerulonephr studi aim identifi mechan immunoregulatori effect vaccin diphtheria tetanus toxoid paramet adapt immun children kidney patholog limit studi aim studi effect revaccin diphtheria tetanus prolifer differenti immunocompet cell format specif antibodi cours diseas children glomerulonephr gn | D056747 | T061 |
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