PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,672,440 | candida bloodstream infect dire complic hospit covid patient three case singl center northern israel patient sever coronavirus diseas covid suscept superimpos infect | D000086382;D058387;D060085;D003428 | T047;T067 |
34,672,439 | covid seroposit rate wave israel israel experienc three wave coronavirus diseas covid infect sinc late februari lockdown measur employ contain infect rate cooper israel ministri health serolog test conduct four health mainten organ hmo order estim nation infect rate proport previous undetect diseas | D000086382;D000087124;D003140;D063189 | T058;T047;T059;T067 |
34,672,437 | variant donor splice site lead skip myh exon recurr rna defect caus herit thorac aortic aneurysm dissect andor patent ductus arteriosus pathogen variant myh associ either herit thorac aortic aneurysm dissect htaad patent ductus arteriosus pda syndrom megacysti microcolon intestin hypoperistalsi syndrom mmih | D022821 | T086 |
34,672,436 | pediatr asthma control covid pandem systemat review meta analysi onset coronavirus diseas covid pandem mani expert expect asthma associ morbid sever acut respiratori syndrom coronavirus infect would dramat increas howev studi suggest appar increas asthma relat morbid children asthma even possibl children may improv outcom understand relationship covid pandem asthma outcom perform articl | D001249;D000086382 | T047;T067 |
34,672,435 | partner decis support parent perspect complet pre visit pediatr asthma questionnair via patient portal collect patient report data demonstr improv asthma outcom one method collect inform electron patient portal practic patient portal use pediatr specif asthma manag low uptak | D001249;D000072638;D010372 | T091;T047;T170 |
34,672,434 | airway clearanc exercis peopl cystic fibrosi balanc longev life airway clearanc integr part cystic fibrosi cf care almost long cf identifi condit diagnosi neonat end life care airway clearanc everyday aspect life ad consider treatment burden live peopl cf mani differ techniqu use airway clearanc evolv time aim improv effect support adher recent consid impact burden popular thought whether airway clearanc could replac exercis new precis therapi form cftr modul avail cf landscap rapid chang rais question whether certain treatment need depend factor cftr mutat age pre exist lung damag start cftr modul individu cf may need differ level intens type mainten treatment precis medicin like lead need increas precis individu manag around mainten therapi airway clearanc | D003550 | T047 |
34,672,433 | anti prp monoclon antibodi novel treatment neurogenesi mous model alzheim diseas alzheim diseas ad common degen diseas character cognit impair memori declin languag disord effect treatment neurogenesi indic ad may play import role pathogenesi ad target pathway new idea treatment diseas recent studi reveal cellular prion protein prp receptor oligom regul neurogenesi elev express relat cell differenti aim present studi investig neuroprotect effect prp monoclon antibodi via neurogenesi promot appp transgen mice induc cell model ad | D000544;D011328 | T048;T047;T116;T005 |
34,672,432 | increas life expect cystic fibrosi advanc challeng sinc first descript cystic fibrosi signific advanc qualiti life longev peopl live diseas articl describ mileston last year perceiv remain barrier normalci popul | D003550 | T047 |
34,672,430 | effect saw palmetto extract vanilloid receptor trpv transient receptor potenti vanilloid subtyp trpv may play signific role pathophysiolog bladder present studi investig effect herbal product saw palmetto extract spe trpv mediat ca influx specif h resiniferatoxin h rtx bind trpv hek cell express trpv hekvr cell | D010936;D050916 | T192;T116;T121;T123 |
34,672,429 | bacteri metabol pathogenesi intim intertwin time metabol model come action take snapshot recent understand bacteri metabol bacteri host metabol interplay infect highlight key outcom challeng practic implement bacteri metabol model comput tool pathogenesi field | D001419 | T007 |
34,672,428 | factor associ media use parent inform cross section studi among parent children age year media use may strengthen parent capac deal parent issu studi examin factor associ media use parent inform | D016487;D010290 | T102;T054;T099 |
34,672,427 | camera assist nurs observ restless patient acut care set multi method feasibl studi evalu implement practic accept camera assist observ restless patient acut care ward | D009732 | T058 |
34,672,426 | associ imbal intestin flora sever diseas inflammatori factor adiponectin vascular endotheli function hypertens patient explor relationship sever hypertens imbalanc intestin flora inflammatori factor adiponectin adpn vascular endotheli function primari hypertens patient accord grade criteria hypertens total patient primari hypertens hospit april juli divid grade group n grade group n grade group n fece research subject collect extract deoxyribonucl acid dna detect composit intestin flora subsequ peripher blood collect determin chang inflammatori factor interleukin il il tumor necrosi factor tnf il serum immunoglobulin g igg igm adpn vascular endotheli function relat endothelin et nitric oxid vascular endotheli growth factor vegf intercellular adhes molecul icam signific differ gender age bodi mass index bmi proport smoker diet habit probiot antihypertens medic use number diabet case among group p found invers associ blood pressur measur microbi divers particular microbi rich p among four major kind intestin flora composit firmicut p bacteroidet p show obvious differ among three group consist trend chang abund firmicut bacteroidet intestin flora imbal close relat sever hypertens inflammatori factor adpn vascular endotheli function | D000069196 | T007;T001 |
34,672,425 | print embed metamateri manufactur conform metamateri remain major challeng project micro stereolithographi print technolog combin liquid metal fill method employ fabric metamateri character embed featur effect protect metal reson layer extern influenc integr mold macro micro structur function structur demonstr robust flexibl propos method three type metamateri fabric orthogon split ring reson metamateri bionic compound eye conform metamateri five layer broadband conform metamateri form hemispher moth eye cost tedious time consum convent fabric method layout fill channel optim polydimethylsiloxan coat post treatment process appli smooth surfac rough caus staircas effect print improv transmiss perform metamateri devic transmiss properti measur use terahertz time domain spectroscopi system experiment result show method propos paper make metamateri manufactur longer limit complex structur effect expand applic rang metamateri | D066330;D000076227 | T074;T073 |
34,672,421 | contribut nfkb insertiondelet attg polymorph suscept gastrointestin cancer meta analysi nuclear factor kappa b nf b pleiotrop transcript factor function critic contributor tumorigenesi grow number case control studi carri analys potenti contribut nf b gene variant gastrointestin cancer risk yet remain conflict conclus therefor conduct date meta analysi evalu relationship nf b gene insert delet polymorph name insdelattg rs suscept gastrointestin cancer search pubm embas medlin databas updat april relev studi meta analysi carri softwar stata quantif relationship determin comput combin odd ratio or correspond confid interv cis sensit analysi funnel plot begg rank correl test also appli find indic insdelattg polymorph could signific impact suscept gastrointestin cancer five genet model insdelattg polymorph remark link risk colorect gastric oesophag cancer respect signific role insdelattg observ certain subgroup find suggest nf b gene insdelattg polymorph may predispos gastrointestin cancer suscept | D020022;D016254;D011110;D017384 | T049;T032;T063;T045 |
34,672,418 | rollercoast emot integr review emot impact health profession student learn simul base educ simul base educ establish specif learn environ capabl activ emot task research identifi stress anxieti relat simul howev role various emot experi simul favour learn still unclear review describ interpret synthes current research find health profession student experi emot effect student learn simul | D004508;D000066908 | T065 |
34,672,417 | nanoscal hybrid implant surfac osterix mediat osseointegr endoss implant surfac topographi direct affect adher cell respons follow implant aim studi examin impact nanoscal topograph modif titanium implant osterix gene express sinc gene report key factor bone format titanium implant smooth nanoscal topographi implant femur osterix cherri mice day implant integr evalu use scan electron microscopi sem evalu cell adhes implant surfac histolog nanotomographi nanoct observ quantifi form bone implant interfac flow cytometri quantifi osterix express cell adjac tissu real time pcr qpcr quantifi osteoinduct osteogen gene express implant adher cell sem reveal topographi depend adhes cell earli timepoint nanoct demonstr greater bone format nanoscal implant interfaci osteogenesi confirm histolog day smooth nanosurfac implant flow cytometri reveal greater number osterix posit cell femur implant nanoscal versus smooth implant compar smooth surfac implant nanoscal surfac adher cell express higher level osterix osx alkalin phosphatas alp pair relat homeobox prx dentin matrix protein dmp bone sialoprotein bsp osteocalcin ocn conclus nanoscal surfac implant demonstr greater bone format associ higher level osterix express day heal period direct evid surfac associ gene regul involv nanoscal mediat osteoinduct pathway util osterix direct adher cell osteoinduct | D015921;D016348 | T074;T042 |
34,672,414 | histamin murin narcolepsi genet immun model tell us increas number histaminerg neuron identifi label histidin decarboxylas hdc synthesi enzym unexpect found patient narcolepsi type nt quest enlighten evalu whether increas hdc cell number express level would detect mous model diseas order provid proof concept revel possibl mechan compens loss orexin neuron andor induc express consequ local neuroinflamm state like accompani nt explor compensatori hypothesi also studi noradrenerg wake promot system immunohistochemistri hdc orexin melanin concentr hormon mch use count neuron quantit pcr hdc orexin mch tyrosin hydroxylas perform evalu level mrna express hypothalamus dorsal pon quantif achiev genet neuroinflammatori model narcolepsi major orexin impair name orexin defici orex ko orexin hemagglutinin orex ha mice respect number hdc neuron mrna express level unchang orex ko mice compar control similar found chang tyrosin hydroxylas mrna express dorsal pon group despit presenc protract local neuroinflamm wit presenc reactiv microglia found chang number neuron express hdc orex ha mice compar control import correl found condit hdc orexin find indic mice express histamin noradrenalin two wake promot system modul orexin level whether lack orexin constitut induc adult age show thus compens also show recruit histamin local neuroinflamm studi need defin role histamin pathophysiolog nt | D006632;D009290 | T047;T121;T109;T123 |
34,672,413 | cidea express sat adolesc girl obes unfavor pattern abdomin fat distribut studi investig whether variat cell death induc dna fragment factor alpha subunit like effector cidea mrna express protein level modul pattern abdomin fat distribut adolesc girl obes | D051017;D009765;D050151 | T116;T047;T024;T123 |
34,672,410 | engin plant isoprenyl diphosph synthas develop irregular coupl activ perform mutagenesi regular isoprenyl diphosph synthas id neryl diphosph synthas solanum lycopersicum slnpps structur relat analogu perform non head tail coupl two dimethylallyl diphosph dmapp unit lavandulyl diphosph synthas lavandula x intermedia lilpp wild type slnpps catalys regular coupl isopentenyl diphosph ipp dmapp cis orient result format neryl diphosph howev enzym fed dmapp abl catalys coupl two dmapp unit synthes two irregular monoterpen diphosph structur elucid nmr analysi dephosphoryl product one alcohol lavandulol second compound tran isom planococcol first exampl irregular cyclobutan monoterpen stereochem configur irregular activ slnpps constitut regular activ reveal enzym suppli dmapp absenc ipp exchang asparagin histidin consider enhanc non head tail coupl still observ absenc ipp irregular activ mutant reach regular activ obtain result prove regular id promis start point protein engin aim develop irregular activ lead novel monoterpen structur | D015202 | T063 |
34,672,409 | role flower gene toler arabidopsi thaliana cucumb mosaic virus genet basi plant toler parasit poor understood previous shown toler arabidopsi thaliana pathogen cucumb mosaic virus achiev chang host life histori trait infect result delay flower realloc resourc veget growth reproduct system analys genet determin toler use recombin inbr line famili deriv cross two access extrem phenotyp three major quantit trait loci toler identifi co locat three flower repressor gene flc fri hua role gene toler examin genotyp carri function nonfunct allel function allel flc togeth fri andor hua requir toler resourc realloc growth reproduct analys flc allel wild access differenti modul flower time show rank differ effect toler flower result pinpoint role flc thaliana toler cucmber mosaic virus novel major find flc recogn previous involv plant defenc although toler associ delay flower allow resourc realloc result indic flc regul toler flower initi differ mechan thus open new avenu research interplay defenc develop plant | D017360;D029681;D017799 | T116;T002;T005 |
34,672,408 | strength genet counselor patient relationship associ extent increas empower patient arrhythmogen cardiomyopathi genet test genet counsel gc increas recommend cardiovascular set multipl guidelin recommend gc patient risk inherit cardiovascular condit scant data howev describ patient outcom guid evid base care studi quantifi influenc strength genet counselor patient relationship outcom individu refer first time gc john hopkin arrhythmogen cardiomyopathi acm center survey prior visit immedi genet test result order session return outcom measur select base reciproc engag model gc includ empower assess genet counsel outcom scale gcos anxieti assess cardiac anxieti questionnair caq genet counselor patient therapeut allianc assess work allianc inventori wai sr respons rate patient genet test order prior gc visit signific increas gcos score mean point within week post gc session p signific differ gcos chang patient genet test order previous attend pre test counsel versus p averag caq score high baselin signific invers relationship pre gc caq score extent increas gcos score p post gc control baselin anxieti strong posit relationship wai sr score gcos chang b ci p result demonstr signific increas empower gc acm patient outcom reliant order genet test instead sensit qualiti genet counselor patient relationship genet counselor strive improv empower focus reduc pre visit anxieti allianc build patient | D009202;D000072117 | T097;T047 |
34,672,407 | cross section survey australian new zealand clinic staff explor attitud regard medic prescript administr neonat emerg survey australasian neonat medic nurs staff determin confid regard medic use prior experi medic error common resourc utilis neonat emerg | D011307;D004630 | T058;T170;T046 |
34,672,405 | effect modifi levonorgestrel releas intrauterin system human adenomyosi heavi menstrual bleed levonorgestrel releas intrauterin lng ius system effect primari treatment adenomyosi howev high expuls rate aim modifi system allow affixion myometrium evalu expuls rate effect side effect patient adenomyosi heavi menstrual bleed | D062788;D007436;D008595 | T074;T047;T046 |
34,672,404 | interplay environment constraint bioturb matground develop along marin deposit profil ordovician radiat studi document distribut matground wide varieti environ record ordovician lashkerak ghelli format alborz mountain northern iran order evalu control distribut along marin deposit profil detail faci analysi allow differenti three group faci associ lower upper ordovician deposit lashkerak format estuarin system ii wave domin shorefac offshor complex iii mix river wave influenc deltaic system middl upper ordovician deposit ghelli format divid two group faci associ tide influenc deltaic success ii deep water fan system microbi induc sedimentari structur miss present deposit form central estuarin basin lashkerak format proxim lobe lobe fring deep water turbidit fan ghelli format contrari miss absent deposit wave domin shorefac offshor complex river tide domin delta various subenviron incis wave domin estuari ie bayhead delta estuari mouth deep marin turbidit fan system ie turbidit channel slope outer lobe lack evid mat build microorgan deltaic system may result two factor high physico chemic stressor caus river induc process increas degre sediment disturb biodiffus bioirrig burrow organ format microbi mat wave domin shorefac offshor complex inhibit activ abund divers infauna capabl rework sediment analysi show spatial distribut microbi mat control interplay environment factor innov anim substrat interact most express secular chang bioturb studi support notion agronom revolut diachron margin marin deep sea ecosystem lag behind shallow marin set | D017753;D019015 | T070;T082;T068 |
34,672,401 | tetrametal copper complex nanoscal copper select switchabl dehydrogen hydrogen light discret photoact ultrafin copper nanoclust fewer hundr atom stimuli respons switchabl redox activ state high desir control two differ antagonist reaction herein mix valent tetrametal copper complex c n n schiff base ligand disclos five differ cu cu interact use generat photoact nanoscal copper lcu n reduct coordin imin amin c presenc ligand provid stabil help homogen materi organ solvent cluster show stimuli light respons switch reduc oxid lcu n cuo state allow serv high poor activ bistat relat rate fold catalyst dehydrogen alcohol aldehyd hydrogen nitroaromat amino aromat light | D000438;D003300 | T196;T121;T109;T123 |
34,672,400 | format stabl ni iii n confus porphyrin aid ethoxi group report synthesi character reactiv two stabl ni iii n confus porphyrin ncp complex metal oet ncp nicl h chcl etoh gave oet ni ii ncp initi easili oxid air form ni iii complex ncp inner c oxid bis ethoxi modifi ni iii complex synthes oxid pifa ethanol chcl structur determin singl crystal x ray diffract analysi unusu long ni iii c bond observ g factor g observ epr spectra confirm paramagnet ni iii complex compar experi show ethoxi group play import role format reduct nabh regener complex | D009532;D011166 | T109;T196;T123 |
34,672,396 | advanc qualiti control fenugreek seed use chromatograph spectroscop dna base techniqu comprehens review fenugreek use tradit remedi sinc ancient time long histori use medic ailment antidiabet anticarcinogen hypocholesterolem antioxid antibacteri hypoglycem gastric stimul anti anorexia agent major activ constitu includ alkaloid fibr saponin protein amino acid | D029910 | T002 |
34,672,395 | luteal phase length endometri edema behavior differenti post ovulatori event giant panda ailuropoda melanoleuca despit decad reproduct research giant panda ailuropoda melanoleuca post ovulatori phase continu confound zoologist conserv breed center around world often result signific invest time resourc without reproduct success purpos project document compar post ovulatori characterist non product product breed individu consecut year multidisciplinari approach use monitor visit femal giant panda toronto zoo luteal phase first two full reproduct cycl monitor occur via urin endocrin analysi week ultrasound examin continu behavior observ reproduct cycl consist pseudopregn character extend luteal phase day identif endometri edema fold ultrasound examin lack strong associ behavior pattern urinari progestagen secret reproduct cycl includ increas feed time primari progestagen rise compar previous year follow simultan decreas appetit increas inact rest sit upright pre partum associ behavior chang began day birth twin day post ovul fetus detect via ultrasound day pre partum result suggest absenc pre partum behavior ultrasound evid endometri edema without fetus extend luteal phase may indic pseudopregn giant panda simultan monitor morpholog behavior urinari endocrin profil show clear differ success unsuccess reproduct year | D001503 | T015 |
34,672,394 | valu right ventricular function assess acut pulmonari embol pulmonari embol pe common life threaten diseas mortal relat right ventricular rv dysfunct | D011655;D018497 | T047;T046 |
34,672,392 | clinician patient attitud toward use organ hepat c virem donor impact accept contemporari review use hepat c hcv nat posit allograft remain unusu cluster center conduct contemporari literatur review assess whether patient clinician attitud toward virem organ impact accept | D000998;D006526 | T047;T121 |
34,672,391 | robust estim herit coronari diseas risk individu type diabet type diabet td import herit risk factor coronari arteri diseas cad risk diseas increas metabol syndrom ms avail larg scale genom wide associ data aim elucid genet burden cad risk td predispos individu within context ms share genet architectur mendelian random mr analys support causal relationship td cad odd ratio per log odd unit confid interv ci p simultan adjust mr analys effect td instrument includ blood pressur dyslipidaemia obes attenu associ td cad ci bayesian locus overlap analysi identifi region causal variant under td cad genet signal fdr five mhc lpl abo rai mcr region contain genom wide signific p associ trait given small effect size observ genom wide associ studi complex diseas even potenti target region implic like magnitud cad risk reduct might achiev pure td therapi | D003324;D003924 | T047 |
34,672,390 | mendelian random multivari general linear model framework mendelian random mr applic instrument variabl iv method observ data iv genet variant mr method applic general exponenti famili distribut current well character adapt general linear model framework iv set propos general mr method applic full rank distribut exponenti famili empir bias coverag estim via simul propos method compar sever exist mr method real data analys perform use data regard studi estim potenti causal effect smoke frequenc stroke risk african american simul binari variat weak instrument propos method lowest median q q bias compar sps wald method low bias observ throughout simul scenario well coverag propos method simul count variat propos method perform compar sps wald method maintain consist low bias sri bias toward null real data analys find evid causal effect smoke frequenc stroke risk propos mr method low bias accept coverag across wide rang distribut scenario instrument strength provid parsimoni framework asymptot hypothesi test compar exist two stage procedur | D057182;D012907 | T062;T055 |
34,672,389 | preval predictor left atrial appendag inact patient rheumat mitral stenosi sinus rhythm observ studi system thromboembol known complic rheumat mitral stenosi rms sinus rhythm sr left atrial appendag laa commonest site thrombus format usual hypocontractil inact patient aim studi preval laa inact laai sever rms assess independ predictor | D020517;D001281;D008946 | T047;T023;T046 |
34,672,387 | compar analysi phasic left atrial strain left ventricular posterolater strain pattern discrimin fabri cardiomyopathi form left ventricular hypertrophi classic echocardiograph sign fabri cardiomyopathi fc left ventricular hypertrophi lvh posterolater strain impair plsi papillari muscl hypertrophi may limit diagnost accuraci clinic practic aim evalu diagnost valu left atrial la strain impair compar classic echocardiograph find discrimin fc | D002312;D017379 | T047 |
34,672,386 | case variant parachut mitral valv associ mitral annular disjunct arrhythm syndrom parachut mitral valv pmv rare congenit cardiac valvular anomali often associ congenit cardiac defect particular shone complex may infrequ occur isol pmv variant predomin associ mitral stenosi ms rare mitral regurgit mr present case middl age femal evalu syncop episod found atyp variant pmv disproportion long anterior mitral leaflet bileaflet mitral valv prolaps mitral annular disjunct without associ ms mr first case report highlight particular constel find | D008944;D008945;D008946 | T047 |
34,672,385 | postop oral energi protein intak enhanc recoveri surgeri program incorpor earli enter nutrit pancreaticoduodenectomi retrospect studi although postop earli oral feed enhanc recoveri surgeri era program pancreaticoduodenectomi pd deem safe assess oral intak insuffici studi aim investig postop oral intak effect era program incorpor earli enter nutrit en | D000080482;D016577 | T061 |
34,672,384 | longitudin pattern urinari incontin associ predictor women type diabet urinari incontin ui women dynam condit numer risk factor yet studi focus examin preval singl time object studi describ long term time cours ui women type diabet td | D003922;D014549 | T047;T046 |
34,672,383 | larg paradox embolus patent foramen oval follow arterioven graft thrombectomi year old man end stage renal diseas hemodialysi arterioven fistula left upper extrem present hemodialysi session thrombosi arterioven fistula patient underw surgic thrombectomi patient later show evid peripher embol livedo reticulari transthorac transesophag echocardiogram reveal larg thrombus cm right atrium prolaps left atrium via patent foramen oval anoth thrombus adher apic wall right ventricl thrombus left atrium intermitt cross mitral valv enter left ventricl | D004617;D019320;D054092;D011655;D013927 | T019;T033;T046;T047 |
34,672,382 | comorbid poverti social vulner risk factor mortal pregnant women confirm sar cov infect analysi posit pregnanc includ matern death mexico mortal pregnanc due coronavirus diseas covid current health prioriti develop countri identif clinic sociodemograph risk factor relat mortal pregnant women covid could guid public polici encourag women accept vaccin aim evalu associ comorbid socioeconom determin covid relat mortal sever diseas pregnant women mexico | D000091482 | T033 |
34,672,379 | androgen receptor negat regul mitot checkpoint signal induc docetaxel resist castrat resist prostat cancer despit multipl treatment advanc castrat resist prostat cancer crpc current curat therapi patient ultim succumb diseas docetaxel dtx standard first line chemotherapi patient metastat crpc howev drug resist inevit often develop rapid lead diseas progress near patient contrast dtx deploy androgen depriv therapi castrat sensit diseas durabl respons improv outcom observ suggest aberr androgen receptor ar signal acceler dtx resist crpc studi demonstr ar dysregul mitot checkpoint critic pathway involv anticanc action dtx | D059447;D064129 | T043;T191 |
34,672,378 | outcom adjunct radiat therapi treatment mast cell tumor dog assess toxic multicent observ studi dog radiat therapi common use adjunct incomplet surgic excis dog mast cell tumor mct optim dose fraction regimen yet determin | D004283;D009369 | T191;T047 |
34,672,377 | long covid syndrom associ brain fog investig frequenc brain fog larg cohort patient document coronavirus diseas covid surviv ill also scrutin potenti risk factor associ develop brain fog adult patient year age refer healthcar facil anywher far provinc februari novemb includ patient confirm covid diagnosi phone call least month discharg hospit obtain current inform questionnair specif design data collect total patient inclus criteria peopl report long covid syndrom lcs lcs associ brain fog report patient femal sex odd ratio respiratori problem onset intens care unit icu admiss signific associ report chronic post covid brain fog patient larg popul base studi report chronic post covid brain fog signific associ sex femal respiratori symptom onset sever ill icu admiss | D000086382 | T047;T067 |
34,672,376 | role toll like receptor modul cytokin storm signal sar cov induc covid balanc immun regul crucial recogn invad pathogen kill elimin toll like receptor tlrs key regul innat immun system help identifi self nonself molecul eventu elimin nonself endosom tlr main tlr tlr tlr membran bound tlr role induct cytokin storm tlr recogn ssrna sar cov replic dsrna recogn tlr drive trif mediat inflammatori signal like nf b mapk signal lead signific transcript translat pro inflammatori gene releas inflammatori molecul system circul caus imbal system whenev imbal occur surg pro inflammatori mediat observ blood includ cytokin like interleukin il il il il il interferon ifn tumor necrosi factor tnf il il one drive factor bring cytokin storm system circul migrat organ caus multipl organ failur lead death individu sever ill | D000086382;D000086402 | T047;T005;T067 |
34,672,374 | natur spring water gargl sampl altern nasopharyng swab sar cov detect use laboratori develop test object studi valid use spring water gargl swg altern oral nasopharyng swab onp sar cov detect laboratori develop test healthcar worker adult general popul present one two covid screen clinic montral qubec citi prospect recruit provid gargl sampl addit standard onp pair specimen analyz use thermal lysi follow laboratori develop nucleic acid amplif test ld naat detect sar cov compar perform analysi perform individu consid infect posit result obtain either sampl total adult particip recruit invalid result n exclud analysi sar cov detect particip sampl onp swg overal sensit ci onp ci p swg mean onp cycl threshold c valu signific lower concord pair sampl compar discord one vs p conclus use ld naat thermal lysi swg less sensit sampl method onp howev higher accept swg might enabl higher rate detect popul base perspect nonetheless patient high clinic suspicion covid repeat analysi onp consid sensit swg use naat preced chemic extract evalu | D000086382;D060985 | T070;T047;T067 |
34,672,373 | concern multipl nomenclatur system sar cov multipl nomenclatur system sar cov confus sever issu emerg variant concern variant interest pose increas risk global health assist public discuss communic nonscientif audienc signific mutat ultim inform ongo respons covid pandem scientist need develop easi pronounc nonstigmat label signific mutat | D000086382;D000086402 | T047;T005;T067 |
34,672,372 | sentinel lymph node biopsi thin melanoma transit ajcc th edit increas posit rate danish popul base studi patient evalu outcom sentinel lymph node biopsi slnb patient thin melanoma implement ajcc th edit ajcc identifi predictor posit sentinel lymph node sln | D021701 | T060 |
34,672,371 | histolog benign pi rad lesion contain cancer associ epigenet alter detect rate clinic signific prostat cancer improv use multiparametr magnet reson imag mpmri yet even mri guid biopsi high risk lesion prostat imag report data system pi rad histolog benign unclear fals posit due diagnosticsampl error pathophysiolog alter better understand test histolog benign pi rad lesion common malign epigenet alter | D019175;D061705;D011467;D011471 | T044;T191;T023;T060 |
34,672,370 | generic icd program outcom generic icd program shock reduct program extrapol trial one manufactur anoth may reduc non essenti icd therapi beyond seen random trial howev benefit risk unknown purpos retrospect cohort studi evalu impact standard program protocol base generic program across manufactur | D000465;D011474 | T058;T170 |
34,672,368 | languag acquisit multilingu societi english vocabulari norm predictor singaporean children studi infant vocabulari develop track multilingu societi singapor within socioeconom divers sampl sampl compris infant month femal male chines race malay indian mix race declin provid race inform children vari english languag exposur socioeconom status analys focus identifi demograph predictor english vocabulari size multilingu expos infant adapt macarthur bate communic develop inventori english mandarin malay provid well english vocabulari norm account variat english exposur manuscript report first set english languag norm calibr english exposur multilingu infant non western set | D019303;D014825 | T171;T170 |
34,672,366 | influenc sex tic sever psychiatr comorbid profil patient pediatr tic disord investig sex relat differ tic sever tic relat impair psychiatr comorbid childhood | D001289;D003865;D013981;D020323;D005879 | T048;T047;T184;T037 |
34,672,364 | tonsillectomi obstruct sleep disord breath stay could go children requir oxygen beyond hour surgeri pass sleep room air challeng srac safe discharg regardless polysomnogram psg result comorbid | D001249;D020181;D014068 | T047;T061 |
34,672,363 | tangenti flow filtrat facilit fraction pegyl low high molecular weight polymer hemoglobin biophys properti various type hemoglobin hb base oxygen carrier hboc develop red blood cell substitut treat blood loss blood avail among hboc glutaraldehyd polymer hbs attract signific attent due facil synthet rout abil expand blood volum deliv oxygen hemopur oxyglobin polyhem well known commerci develop glutaraldehyd polymer hbs unfortun oxyglobin approv fda veterinari use unit state hemopur polyhem fail phase iii clinic trial due abil extravas blood volum tissu space facilit nitric oxid scaveng tissu deposit iron elicit vasoconstrict hypertens oxid tissu injuri fortun conjug poli ethylen glycol peg surfac hb capabl reduc vasoact hb creat hydrat layer surround hb molecul increas hydrodynam diamet reduc tissu extravas sever commerci pegyl hbs mp sanguin euro peg hb develop clinic use longer circulatori half life improv safeti compar hb howev commerci product exhibit relat high oxygen affin compar hb limit clinic use dualli address limit prior generat polymer pegyl hbs current studi describ pegyl polymer bovin hb peg polybhb tens relax r quaternari state via thiol maleimid chemistri produc hboc low high oxygen affin biophys properti peg polybhb measur compar commerci polymer pegyl hboc state peg polybhb possess higher hydrodynam volum p previous generat commerci pegyl hbs r state peg polybhb exhibit signific lower haptoglobin bind rate precursor polybhb indic potenti reduc clearanc cd monocyt macrophag thus state peg polybhb expect function promis hboc due low oxygen affin enhanc stealth properti afford peg hydrat shell | D001802;D006454;D011092 | T116;T121;T109;T123;T130 |
34,672,362 | carotid intima media thick risk mild cognit impair systemat review meta analysi mild cognit impair mci earli phase cognit declin signal begin sever neurolog diseas carotid intima media thick cimt shown correl mci develop studi conduct investig impact elev cimt risk mci adult literatur search conduct pubm embas cochran librari scopus googl scholar cinahl databas till juli keyword carotid intima media thick cimt imt cognit impair cognit cognit declin mild cognit impair mci pool standard mean differ smd odd ratio confid interv ci determin factor diseas associ use either fix model eight studi involv mci case normal subject includ meta analysi show signific associ increas cimt risk mci smd ci howev sensit analysi reveal outlier studi signific affect effect size omit outlier studi evalu meta analysi reveal signific associ cimt risk mci smd ci signific associ also observ subgroup analysi caucasian popul smd ci asian popul smd ci elev cimt pose potenti risk mci howev popul base studi requir corrobor find | D059168;D060825 | T048;T201 |
34,672,361 | associ asthma menier diseas nest case control studi studi aim investig associ menier diseas prior histori asthma | D001249;D008575 | T047 |
34,672,360 | overview immobil enzym synthet polymer nanofib fabric electrospin arrang type support signific impact effici immobil enzym dimension fibrous materi one desir support enzym immobil due high surfac area volum ratio intern poros eas handl high mechan stabil allow higher enzym load releas final lead better catalyt effici fortun enzym resid insid individu nanofib remain encapsul retain three dimension structur properti protect enzym toler harsh condit ph variat high temperatur probabl enhanc enzym stabil review articl discuss immobil enzym synthet polym fabric nanofib electrospin techniqu rapid gain popular one practic way fibric polym metal oxid composit micro nanofib result interest use nanofib immobil enzym furthermor present research electrospun nanofib enzym immobil primarili limit lab scale industri scale still challang primari futur research object paper investig use electrospun nanofib enzym immobil includ increas yield transfer biolog product commerci applic | D055162;D004800;D011108 | T116;T130;T104;T122;T070;T126 |
34,672,359 | current osteomyel mous model systemat review osteomyel inflammatori bone diseas caus infect microorgan lead gradual bone loss due difficulti studi osteomyel direct patient anim model allow research investig pathogenesi infect develop novel prophylact anti inflammatori antimicrobi treatment strategi review specif focus vivo mous osteomyel studi avail literatur thus systemat search web scienc pubm conduct use queri infect mice mous murin model model arthroplasti fractur intern fixat intern fixat prosthesi implant osteomyel critic assess studi accord inclus exclus criteria studi includ detail analysi base model characterist studi classifi five subject group haematogen osteomyel post traumat osteomyel bone implant relat infect peri prosthet joint infect fractur relat infect addit characterist mice use inbr strain age gender characterist pathogen use inocul method type anaesthesia analgesia use surgeri procedur evalu pathogen infect micro organ describ overal mous excel first step vivo model studi pathogenesi inflamm heal process osteomyel evalu novel prophylaxi treatment strategi | D010019;D013203 | T047 |
34,672,357 | treatment low dose isotretinoin effect patient moder inflammatori acn recommend isotretinon dose sever nodulocyst acn almost year mgkgday reach cumul dose mgkg moder sever acn treat long term system antibiot carri risk microbi resist skin och intestin flora swedish medic product agenc approv patient acn recur oral antibiot given two month period consid isotretinoin treatment dose regimen chang patient moder inflammatori acn papulopustular studi recent year shown treatment low dose isotretinoin mgkgday acn recoveri independ cumul dose effect less frequent less sever mucocutan side effect reduc risk acn flare consider less expens tradit dose durat treatment howev prolong pregnanc prevent program must follow | D000152;D003879;D015474 | T047;T121;T109 |
34,672,356 | effect behaviour medic rehabilit real life condit germani propens score match analysi germani behaviour medic rehabilit programm implement patient musculoskelet disord addit mental health comorbid aim cohort studi assess relat effect behaviour medic rehabilit real life condit | D009140;D012050 | T047;T061 |
34,672,348 | air pollut determin undernutrit preval among five children india exploratori studi associ air pollut preval undernutrit indic name anaemia stunt wast underweight among five children india investig | D000397;D044342 | T080;T069;T047 |
34,672,347 | subleth effect abamectin develop reproduct detoxif enzym activ relat gene express orient fruit moth lepidoptera tortricida grapholita molesta one import fruit pest worldwid abamectin biolog pesticid frequent use control fruit borer like g molesta part owe translaminar properti studi character toxic abamectin g molesta larva use diet incorpor method subleth effect abamectin develop reproduct detoxif enzym activ relat gene express g molesta assess result show lc lc valu insecticid g molesta h post treatment mg l mg l wherea lc lc valu h post treatment mg l mg l compar control subleth concentr abamectin signific increas mortal larva prepupa pupa g molesta prolong durat rd th instar larva prepup pupal period shorten longev adult reduc femal fecund enzymat activ glutathion transferas gst vari signific exposur subleth concentr abamectin cytochrom p monooxygenas carboxylesteras activ signific affect thirteen gst gene signific upregul differ subleth concentr abamectin combin find increas understand effect abamectin g molesta potenti role gsts metabol interact abamectin pest applic ration effect use abamectin control g molesta | D009036 | T204 |
34,672,345 | role tender swollen joint assess inflamm psa use ultrasound evalu tender joint tj swollen joint sj assess ultrasound us defin inflamm psa | D013585 | T047 |
34,672,343 | impact nutrit status bodi composit postop outcom pelvic exenter local advanc local recurr rectal cancer pelvic exenter local advanc rectal cancer larc local recurr lrrc rectal cancer provid radic resect local control associ consider morbid aim studi determin risk factor includ nutrit status bodi composit postop morbid surviv pelvic exenter patient larc lrrc | D010385;D012004 | T191;T061 |
34,672,342 | treatment long term outcom breast cancer young women nationwid popul base studi studi aim assess correl long term surviv treatment young women breast cancer | D001943 | T191 |
34,672,335 | adopt advanc chemometr method determin pyridoxin hcl cyclizin hcl meclizin hcl presenc relat impur compar studi nois undesir phenomenon accompani develop wide use chemometr model partial least squar regress plsr support vector regress svr | D003501;D008468 | T121;T109 |
34,672,331 | post pericardiotomi syndrom insight neglect postop issu pericardi effus common complic cardiac surgeri isol post pericardiotomi syndrom pps condit pleuropericardi damag trigger local system inflammatoryimmun respons goal review present complet pictur pps pericardi complic cardiac surgeri highlight avail evid gap knowledg | D006348;D010492 | T061 |
34,672,330 | three organell complex made wrapper contact peroxisom mitochondria respond liver lipid flux chang hepat lipid homeostasi depend intracellular pathway respir fatti acid peroxisom mitochondria system pathway secret fatti acid bloodstream either free condens low densiti lipoprotein vldl triglycerid system intracellular pathway interdepend unclear whether integr singl cellular circuit report mous liver wrapper distinct endoplasm reticulum er compart appar fatti acid vldl secret function connect peroxisom mitochondria correl light electron microscopi quantit serial section electron tomographi three dimension organell reconstruct analysi show number peroxisom wrapper mitochondria complex chang throughout fast feed transit doubl vldl synthesi stop follow acut genet ablat mttp liver quantit proteom analysi peroxisom wrapper mitochondria complex enrich fraction indic loss mttp upregul global fatti acid oxid therebi integr dynam three organell associ hepat fatti acid flux respons therefor liver lipid homeostasi occur converg system intracellular fatti acid elimin pathway peroxisom wrapper mitochondria complex | D020675;D040901 | T091;T026 |
34,672,328 | genom wide identif character fur bind site cyanobacteria synechocysti sp pcc pcc ferric uptak regul fur crucial pathogen non pathogen bacteria mainten iron homeostasi well defenc reactiv oxygen speci base dataset genom wide map transcript start site transcriptom data identifi high confid regulon control fur model cyanobacterium synechocysti sp pcc close relat strain base conserv strong iron starvat respons fur bind site occurr regulon compris protein code gene srna isar control individu promot strain respect associ gene function most restrict transport enzym involv uptak storag iron ion except unknown function relev within isiabc operon identifi previous neglect gene encod small cystein rich protein suggest call isi regul iron uptak storag util ultim result interplay fur regulon sever transcript factor ftsh proteas srna isar | D046939 | T007 |
34,672,323 | dynam social correct peer share covid misinform whatsapp brazil onlin covid misinform serious concern brazil home second largest whatsapp user base second highest number covid death examin extent whatsapp user might will correct peer might share covid misinform | D000086382;D061108 | T047;T170;T067 |
34,672,321 | dnam promot inflamm driven tumor develop via enhanc ifn product dnam activ immunoreceptor cell natur killer nk cell express level ligand cd cd regul tumor cell interact dnam cd cell nk cell ligand tumor cell play import role tumor immun previous report mice defici dnam show acceler growth tumor induc chemic carcinogen dimethylbenz anthracen dmba contrari result show tumor develop induc tetradecanoylphorbol acet tpa togeth dmba suppress dnam defici mice model dnam enhanc ifn secret convent cd cell promot inflamm relat tumor develop find suggest inflammatori condit dnam contribut tumor develop via convent cd cell | D000945;D009369 | T129;T191;T116 |
34,672,315 | recent advanc materi hemostat manag traumat hemorrhag fatal event particular larg quantiti blood lost short period time therefor hemostasi becom crucial part emerg treatment small wound hemostasi achiev intrins depend bodi blood coagul mechan howev larg area wound particular battlefield complex wound materi deliv rapid effect hemostasi requir parallel constant progress scienc technolog societi advanc hemostat materi also undergon various iter integr new idea old concept various natur synthet hemostat materi includ hemostat powder adhes hydrogel tourniquet treatment sever extern trauma review cover differ among current avail hemostat materi comprehens describ hemostat effect differ materi base under mechan final solut current issu relat trauma bleed discuss prospect hemostat materi propos | D006490 | T121 |
34,672,314 | develop new high sensit serotonin sensor base green synthes silver nanoparticl decor reduc graphen oxid electrochem detect serotonin hydroxytryptamin ht propos first time use cost effect eco friend nanocomposit agnp rgo synthes situ green reduct process use rosemari leaf extract synthes nanocomposit elabor thin layer character use uv vis ftir tem ei sensit develop sensor evalu differenti puls voltammetri peak current measur voltag mv vs agagcl increas linear nm concentr rang low limit detect pm compar recent studi report literatur obtain innov approach success appli determin serotonin spike artifici urin sampl | D006108;D053768 | T073;T196;T109 |
34,672,311 | colorimetr assay base arginin function gold nanoparticl detect dibutyl phthalat baijiu sampl paper simpl innov colorimetr method establish base dbp induc aggreg arginin function gold nanoparticl arg aunp use sensit determin dibutyl phthalat dbp baijiu sampl morpholog characterist color chang arg aunp caus aggreg show good sensit observ ultraviolet visibl spectroscopi fourier transform infrar ft ir spectroscopi transmiss electron microscopi tem dynam light scatter dls zeta potenti technolog color chang arg aunp red blue due strong non coval interact dbp arg aunp electrostat van der waal forc hydrogen bond lead reduct electrostat repuls nanoparticl aggreg two stage linear equat establish absorpt ratio dbp concentr mg l correl coeffici r detect limit lod estim mg l design arg aunp act depend sensor detect baijiu sampl equal acquir satisfactori recoveri concentr dbp solut mg l color chang clear observ nake eye need sampl prepar techniqu tedious oper quick semi quantit detect dbp success applic propos method baijiu sampl indic potenti detect dbp complex environ sampl | D006046;D053768 | T121;T073;T196 |
34,672,310 | wearabl chem biosens devic basic research commerci market wearabl chem biosensor garner tremend interest due signific potenti tailor healthcar diagnost therapeut develop medic diagnost revolut wearabl chem biosensor rapid emerg wave allow individu perform demand detect obtain requir depth inform contrast commerci wearabl tend miniatur measur physic activ recent progress wearabl chem biosens devic main focus non invas minim invas monitor biomark molecular level wearabl multidisciplinari subject chem biosens one signific technolog review current basic academ research wearabl chem biosens devic commerci transform summar highlight moreov repres wearabl product market individu health manag present strategi identif sens biomark discuss promot develop wearabl chem biosens devic also share limit breakthrough next generat chemo biosensor wearabl home use clinic diagnosi | D015374;D000076251 | T059;T073;T075 |
34,672,309 | util preclin model genet divers improv translat phytochem activ rodent human inform person nutrit mous model essenti tool differ area research includ nutrit phytochem research tradit inbr mous model allow discoveri therapeut target mechan action expand knowledg health diseas howev model lack genet variabl typic found human popul hinder translat result found mice human develop genet divers mous model collabor cross cc divers outbr model use tool overcom obstacl mani field cancer immunolog toxicolog howev tool yet wide adopt field phytochem research demonstr disciplin use cc model potenti provid invalu insight translat phytochem rodent human desper need given challeng numer fail clinic trial field model may prove inform person use phytochem human includ predict interindividu variabl phytochem bioavail efficaci identifi genet loci gene govern respons phytochem identifi phytochem mechan action therapeut target understand impact genet variabl individu respons phytochem insight would prove invalu person implement phytochem human review focus current work perform genet divers mous popul research opportun advantag model offer phytochem research | D004195;D009747;D064209 | T109;T123;T039;T042;T050 |
34,672,308 | anthraquinon fuse enediyn discoveri biosynthesi develop cover end juli anthraquinon fuse enediyn afe subfamili enediyn natur product dynemicin dyn first member afe famili discov thirti year ago subsequ extens studi report mode action interact afe dna use dyn model howev progress discoveri biosynthesi clinic develop afe limit long time past five year four new afe discov signific progress made biosynthesi afe especi biogenesi anthraquinon moieti tailor step moreov streamlin total synthesi afe analogu boost prepar afe base linker drug thus enabl develop afe base antibodi drug conjug adc review summar discoveri mechan action biosynthesi total synthesi preclin studi afe | D001688;D053281 | T121;T109;T123 |
34,672,304 | neochlorogen acid anchor mcu base calcium overload cancer therapi cancer major threat human health worldwid yet clinic therapi remain unsatisfactori studi found tetrastigma hemsleyanum leav flavon tlf intervent could achiev tumor inhibit besid neochlorogen acid na highest absorb peak hplc profil tlf show superior anti prolifer abil tlf could effect trigger apoptosi restrain migrat facilit cytoskeleton collaps suggest key role tlf anticanc properti molecular dock analysi suggest na capabl bind mitochondri ca uniport mcu experi confirm na upregul mcu level permit excess calcium ion influx lead mitochondri calcium imbal dysfunct structur alter ros elev moreov tumor bear mice appli confirm excel tumor inhibit abil na ca abund condit therefor studi uncov na could effect trigger robust mcu mediat calcium overload cancer therapi could util novel strategi futur cancer treatment | D000970;D002118;D015220 | T116;T121;T109;T123;T196 |
34,672,300 | effect cerebr hypoperfus cerebr white matter metaanalysi decreas cerebr blood flow cbf age known induc agingrel cerebr deterior neuron degener white matter wm alter vascular deform howev effect cerebr hypoperfus wm alter remain unclear studi investig relationship cerebr hypoperfus wm total volum chang assess trend cbf wm chang metaanalysi metaanalysi differ cbf compar accord cerebr hypoperfus type effect cerebr hypoperfus total volum wm chang rodent use subgroup analysi studi evalu compar cbf accord type cerebr hypoperfus studi evalu compar effect cerebr hypoperfus total volum wm chang metaanalysi show total volum wm decreas decreas cbf howev reduct inrnth total volum wm greater normal age mice cerebr hypoperfus model mice result suggest reduct cerebr wm volum age process affect factor addit decreas cbf | D066127 | T023;T024 |
34,672,299 | estrogen receptor agonist induc antiedema effect alter estrogen receptor gene express present studi aim examin whether attenu estrogen receptor express prevent propyl pyrazol triol ppt agonist estrogen receptor er diarypropiolnitril dpn agonist estrogen receptor er traumat brain injuri tbi test perform ovariectom femal wistar rat includ sham group vehicl group treat group ppt dpn pptdpn minut tbi bloodbrain barrier bbb disrupt brain water content estim rtpcr andrnwestern blot util evalu esr esr gene protein express data indic ppt dpn pptdpn attenu tbiinduc brain edema also bbb disrupt tbi prevent ppt dpn pptdpntreat tbi anim estrogen agonisttr anim show signific elev esr mrna protein express level brain tissu tbi rat addit data indic signific elev esr mrna protein express level brain tissu estrogen agonisttr tbi rat data show esr esr agonist enhanc er mrna protein level tbi anim brain appear effect contribut neuroprotect function er agonist | D004967;D011960 | T116;T121;T109;T125;T192;T033 |
34,672,298 | level happi depress parent children autism spectrum disord poland numer factor determin sens happi level depress caregiv children autism spectrum disord asd aim paper evalu happi depress inamong famili asd child compar famili neurotyp children studi includ particip particip answer question two questionnair beck depress inventori oxford happi questionnair outcom studi identifi signific differ sens happi level depress among parent children asd compar parent neurotyp children shown parent children asd report lower sens happi higher level depress compar parent neurotyp children also show signific higher level depress relat decreas level happi moreov parent univers educ degre child asd show higher sens happi lower level depress parent secondari educ degre studi group | D000067877 | T048 |
34,672,297 | role nrberk signal neuroprotect effect dexmedetomidin sevofluran induc neurolog dysfunct develop rat brain dexmedetomidin dex potent adrenerg receptor agonist wide appli clinic present studi explor protect effect dex sevofluraneinduc learn cognit impair examin under mechan spraguedawley rat pup expos sevofluran h inject dex differ dose morri water maze test perform evalu learn memori function rat western blot use measur protein level water maze result indic sevofluran treatment increas escap latenc reduc time spent origin quadrant rat protein level nrb phosphoryl erk signific influenc sevofluran ifenprodil administr allevi sevofluraneinduc neurolog impair dex treatment revers effect sevofluran escap latenc time origin quadrant dose manner pretreat dex dramat effect dex regul nrberk signal sevofluran treat rat nrberk signal involv sevofluran induc neurolog impair dex may protect sevofluran induc neurolog dysfunct develop rat brain via regul nrberk signal | D020927;D018696 | T169;T121;T109 |
34,672,296 | effect scopolamin treatment consequ convuls develop cfos express fed fast refe mice fast anticholinerg seizur affect cfos activ brain addit antimuscarin treat fast anim develop convuls soon refeed therefor assess whether cfos express chang fed fast refe anim scopolamin treatment affect chang assess whether chang cfos express convuls purpos balbc mice fast h period use anim treat salin scopolamin halfrnof anim treat salin scopolamin given food min inject anim observ develop convuls min end period brain anim remov percentag cfos activ cell hypothalamus determin immunohistochem convuls occur within h fast scopolamin treatment refeed compar fed anim cfos express signific chang undergo differ fast period signific decreas h fast anim allow eat cfos activ signific increas refedsalin group decreas refedsalin group scopolamin treatment h fast anim increas cfos express decreas h fast anim wherea convuls develop scopolaminetr h refe anim suppress cfos express result demonstr refeed scopolamin treatment induc neuron activ hypothalamus scopolamin induc convuls food intak suppress cfos activ | D005215;D012601 | T033;T121;T109;T055 |
34,672,295 | immun system autism spectrum disord associ therapeut challeng autism spectrum disord asd neurodevelopment disord affect communic behavior histor asd describ pure psychiatr disord genet factor play critic role recent grow bodi literatur emphas import environment immunolog factor pathogenesi autoimmun process attract attent studi provid review autoimmun involv pathogenesi asd thernmicrobiom repres innat immun system central nervous system cns play critic role trigger inflamm besid bidirect communic pathway cns intestin call gutbrainaxi link develop asd moreov higher plasma level proinflammatori cytokin asd patient higher preval autoimmun disord firstdegre famili member affect person clue immun system involv inrnth pathogenesi asd furthermor antiinflammatori drug includ resveratrol palmitoylethanolamid shown promis effect reliev manifest asd although consider advanc made elucid role autoimmun asd pathogenesi studi stronger methodolog need appli knowledg definit treatment asd | D000067877 | T048 |
34,672,294 | inhibit ionotrop glur signal preserv oligodendrocyt lineag myelin ex vivo rat model white matter ischem injuri preterm infant high risk neonat white matter injuri wmi wmi lead reduc myelin inflamm clinic neurodevelopment deficit effect treatment ionotrop glutam receptor iglur induc excitotox contribut oligodendrocyt ol lineag cell loss demyelin brain model neonat adult wmi hypothes simul ischemia oxygenglucos depriv damag white matter via activ iglur signal iglur inhibit short wmi could mitig ol loss enhanc myelin suppress inflamm ex vivo cerebellar slice model develop wmi inhibit iglur signal combin block ampa nmda receptor short simul ischemia restor myelin reduc apoptot ol enhanc ol precursor cell prolifer matur well upregul express transcript factor regul ol develop remyelin find demonstr iglur inhibit postinjuri allevi ol lineag cell loss inflamm promot myelin upon develop wmi find may help develop therapeut intervent wmi treatment | D066127 | T023;T024 |
34,672,293 | brainderiv neurotroph factor nitric oxid contribut protect effect rosiglitazon learn memori hypothyroid rat effect wellknown peroxisom proliferatoractiv receptor gamma ppar agonist rosiglitazon rosi brainderiv neurotroph factor bdnf nitric oxid learn memori investig hypothyroid rat hypothyroid induc immatur wistar rat administr propylthiouracil drink water rat divid four group control hypothyroid hypothyroid treat rosi dose mgkg mgkg memori assess morri water maze mwm passiv avoid pa test follow anesthet brain sampl collect biochem measur hypothyroid increas escap latenc travel path learn trial mwm decreas time spent distanc travel target quadrant probe day hypothyroid also impair avoid behavior rat pa test rosi improv perform rat mwm pa task hypothyroid also decreas hippocamp bdnf level increas metabolit induc oxid damag brain treatment hypothyroid rat dose rosi increas bdnf level decreas metabolit malondialdehyd concentr addit thiol content superoxid dismutas catalas activ increas brain region hypothyroid rat receiv rosi administr mgkg rosi also signific increas serum thyroxin level result present studi show bdnf play role protect effect rosi learn memori impair hypothyroid rat | D019208;D007037 | T116;T047;T123 |
34,672,292 | aklh vaccin decreas plaqu astrocyt microglia activ brain appp transgen mice studi aim investig amyloid peptid plaqu chang astroglia microglia mice alzheim diseas ad studi transgen mice amyloid precursor protein app presenilin ps random aklh vaccin vaccin phosphatebuff salin pbs group mice inject differ time point morri water maze test use identifi spatial learn memori abil mice immunohistochemistri done examin glial fibrillari acid protein transmembran protein tmem correspond enzymelink immunosorb assay elisa done measur interleukin il tumor necrosi factor tnf brain transgen mice morri water maze result show aklh vaccin peptid vaccin could improv cognit function appp transgen mice signific aklh inocul reduc load suppress astrocyt microglia prolifer cortex compar pbs group signific differ two group aklh vaccin decreas brain level il tnf compar pbs group without differ two vaccin conclus earli immunotherapi vaccin reduc activ glial cell deposit plaqu brain transgen mice | D000544;D014612 | T116;T047;T121;T129;T048 |
34,672,291 | preval anxieti relationship anxieti cope style relat factor healthcar worker covid pandem aim investig anxieti preval among healthcar worker covid pandem also relationship signific clinic anxieti cope style relat factor | D000086382;D058873 | T047;T067 |
34,672,290 | relationship covid perceiv risk attitud toward covid vaccin healthcar profession exampl eastern turkey studi aim examin relationship covid perceiv risk attitud toward covid vaccin healthcar profession | D000086382;D000086663 | T047;T200;T067 |
34,672,289 | intraperson social factor problemat internet use among student covid pandem lockdown due covid internet use may becom frequent student possibl negat consequ mental health emerg situat variabl depress anxieti extern locus control could relat problemat internet use hand self esteem intern locus control self efficaci social support play role protect factor problemat internet use present survey aim verifi impact intraperson social factor problemat internet use colleg high school student covid pandem web base cross section studi | D016739;D000086382 | T048;T047;T067 |
34,672,288 | experi reaction toward stage covid among junior doctor india covid pandem first modern pandem occur era social media ubiqu despit stage pandem low number patient various emot behavior chang observ junior doctor studi design assess experi reaction junior doctor tertiari teach hospit north india tamil nadu immedi aftermath nation wide lockdown | D000086382 | T047;T067 |
34,672,287 | weight gain lung transplant patient covid pandem croatia determin effect lockdown measur lung transplant patient covid pandem | D000086382;D016040 | T047;T061;T067 |
34,672,286 | proxim covid mental health symptom among hospit medic staff exposur patient covid signific impact mental health hospit medic staff aim studi examin influenc proxim patient covid consid occup posit gender mental health hospit staff | D000086382;D008603 | T047;T041;T067 |
34,672,285 | psycholog effect covid medic non medic univers student covid pandem signific psycholog effect univers student well segment societi aim studi examin relationship educ field medic non medic educ style onlin face face sociodemograph characterist univers student level depress anxieti stress fear covid | D000086382;D014495 | T092;T047;T073;T067 |
34,672,284 | psycholog effect doubl crisi covid pandem earthquak croatian medic student covid pandem present addit sourc stress anxieti general popul also medic student even normal circumst constant pressur due demand student duti addit experienc seri devast earthquak around zagreb region altogeth could compromis psycholog well aim review evalu psycholog effect two natur disast mental health croatian medic student | D000086382;D055866;D013337 | T097;T070;T047;T067 |
34,672,283 | impact covid pandem mental health medic student univers mostar previous studi shown medic student prone depress tire prone emot exhaust deperson burnout syndrom student term mental health vulner individu age general popul decemb wuhan china outbreak pneumonia caus new coronavirus captur worldwid attent implement strict quarantin measur kept larg number peopl self isol affect aspect life object studi determin direct impact covid pandem mental health qualiti life medic student differ impact gender year studi | D000086382;D013337 | T097;T047;T067 |
34,672,282 | flight icarus preliminari studi emot correl hubri gerontolog nurs sar cov pandem person leadership posit like manifest hubrist symptomatolog longer person exercis power greater power exercis data exist healthcar staff nurs specif gerontolog nurs exercis power colleagu well older person studi aim examin whether emot correl gerontolog nurs experienc hubri serv leadership posit investig possibl gender differ sar cov pandem littl investig period regard emot aspect healthcar profession gerontolog nurs leadership posit complet job affect scale emot labour scale emot regul questionnair general immediaci scale general index job satisfact maslach burnout inventori wong law emot intellig scale state anxieti inventori perceiv cohes scale point likert scale measur hubrist attribut statist signific differ found male femal nurs regard abovement classic administ emot scale hubri analys yield negat correl negat affect hubri research provid first time data regard gerontolog nurs leadership posit suggest various negat posit emot variabl direct relat hubrist symptom group healthcar profession hubrist behavior danger consequ found relat abovement emot variabl research hospit manag consid focus indic attempt prevent phenomena | D002055;D000086382;D009726 | T097;T048;T047;T067 |
34,672,281 | dark tetrad person covid overview psycho somat therapi manag mental health respons recent empir data repres unpreced opportun understand threat situat affect peopl adapt mal adapt behaviour divers way cope situat particular peopl exist mental health issu dark tetrad person found higher form unhealthi relationship cyber well real life covid current paper provid interest alarm pictur peopl dark tetrad person trait form relationship other covid also current paper highlight signific psycho somat therapi manag mental health respons covid | D000086382;D008603 | T047;T041;T067 |
34,672,280 | covid pandem revisit reflect well last nine month short challeng overwhelm heart ach individu collect experi probabl continu shape way live generat come paper aim provid space reflect revisit understand well implement light past month continu obstacl face endeavour offer thought uniqu time could experienc advantag even light extrem pressur stress loss opportun reflect advis guid think behaviour valu belief new hope discoveri hope provid level solac inner strength transform growth select five pillar well discuss turn aim challeng present altern understand applic pillar hope continu develop grow expos new live experi conclud invit colleagu individu quest make sens mean make challeng time | D000086382;D058873 | T047;T067 |
34,672,277 | role famili physician prevent earli detect cancer herzegovina neretva west herzegovina canton studi aim investig analyz role general practitionersfamili physician gpsfps counsel encourag earli cancer prevent percept valu system toward health diseas especi malign diseas knowledg experi nation local cancer earli detect program | D055088;D008175 | T058;T191;T060 |
34,672,276 | predict particip success concurr smoke cessat program inpati treatment alcohol depend predict particip success smoke cessat program alcohol depend patient yield heterogen result moreov find rare base prospect studi clinic routin set identifi predictor prospect studi could help tailor intervent increas particip success rate smoke cessat therapi patient high risk alcohol smoke relat morbid mortal | D000437;D016540 | T048;T055 |
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