anchor_id stringlengths 8 8 | anchor_title stringlengths 5 839 | anchor_abstract stringlengths 2 61.6k | positive_pool listlengths 1 1 | negative_pool listlengths 1 1 |
|---|---|---|---|---|
28759998 | Pharmacist Participation in Acute Ischemic Stroke Decreases Door-to-Needle Time to Recombinant Tissue Plasminogen Activator. | Pharmacists are an important member of the stroke team and aid in obtaining medication and medical history, providing education, managing blood pressure, reviewing exclusion criteria for recombinant tissue plasminogen activator (rtPA), and facilitating reconstitution and administration of rtPA.</AbstractText To determi... | [
[
"27110714",
"Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors.",
"Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that... | [
[
"28285191",
"Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS/NF-κB signaling via downregulation of HNF1b.",
"Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, w... |
35993408 | A Novel Dynamin 2 Mutation Causing Dominant Intermediate Charcot-Marie-Tooth Neuropathy: Case Report. | Dynamin 2 mutations are associated with Charcot-Marie-Tooth neuropathy. We report two siblings with a novel missense heterozygous point mutation (c.1609 G>A) in the highly conserved pleckstrin homology domain in exon 15 of Dynamin 2 presenting with progressive length-dependent sensorimotor polyneuropathy with mixed ... | [
[
"31069783",
"A novel WARS mutation (p.Asp314Gly) identified in a Chinese distal hereditary motor neuropathy family.",
"Distal hereditary motor neuropathy (dHMN) is a clinically and genetically heterogeneous group of inherited neuropathies characterized by distal limb muscle wasting and weakness with n... | [
[
"34686764",
"Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.",
"Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differe... |
40269690 | Prediction model and scoring system for the risk of atrial fibrillation recurrence in patients with atrial fibrillation and obstructive sleep apnoea syndrome: a retrospective case-control study. | The high prevalence of atrial fibrillation (AF) and obstructive sleep apnea syndrome (OSAS) imposes a substantial disease burden on public healthcare, making it a significant health concern in the current era. However, there is currently a lack of risk assessment tools for AF recurrence in patients with AF and OSAS. Th... | [
[
"20725915",
"Blood oxygenation level-dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease.",
"To aid the development of symptomatic and disease modifying therapies in Parkinson's disease (PD), there is a strong need to identify noninvasive measures o... | [
[
"40515391",
"Gene Swin transformer: new deep learning method for colorectal cancer prognosis using transcriptomic data.",
"Transcriptome sequencing has become essential in clinical tumor research, providing in-depth insights into the biology and functionality of tumor cells. However, the vast amount o... |
22890939 | SNR-optimized phase-sensitive dual-acquisition turbo spin echo imaging: a fast alternative to FLAIR. | Phase-sensitive dual-acquisition single-slab three-dimensional turbo spin echo imaging was recently introduced, producing high-resolution isotropic cerebrospinal fluid attenuated brain images without long inversion recovery preparation. Despite the advantages, the weighted-averaging-based technique suffers from noise a... | [
[
"16155898",
"New insights into the mechanisms of signal formation in RF-spoiled gradient echo sequences.",
"RF spoiling is a well established method to produce T(1)-weighted images with short repetition-time gradient-echo sequences, by eliminating coherent transverse magnetization with appropriate RF ... | [
[
"23992544",
"Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice.",
"G-protein coupled receptor (GPR)55 is a novel lipid sensing receptor activated by both cannabinoid endogenous ligands (endocannabi... |
40772448 | Wishes, conflicts, and support needs of informal caregivers of patients in the palliative phase: A qualitative study. | This study explored wishes, conflicts, beneficial, and wished support of informal caregivers (ICGs) providing care to a palliative ill close other. We interviewed five current and 15 bereaved ICGs (25-75 years), and used thematic analyses. ICGs wished to continue life as normal as possible, spend time together a... | [
[
"38845595",
"Staying in control: Characterizing the mechanisms underlying cognitive control in high and low arousal states.",
"Throughout the day, humans show natural fluctuations in arousal that impact cognitive function. To study the behavioural dynamics of cognitive control during high and low arou... | [
[
"40132153",
"Neuroimaging in Children With Inherited Metabolic Epilepsies.",
"Inherited metabolic epilepsies (IMEs) represent inherited metabolic disorders in which seizures, various in types and typically intractable, are one of the predominant manifestations and primary determinants of the overall o... |
40492610 | MDMA-assisted psychotherapy for AUD: Bayesian analysis of WHO drinking risk level and exploratory analysis of drinking behavior and psychosocial functioning at 3 months follow-up. | Safety and tolerability data from the first open-label feasibility study of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for alcohol use disorder was recently published. This paper presents a Bayesian analysis of the impact of MDMA-assisted psychotherapy on treatment success, defined as 2-level reduc... | [
[
"38619933",
"Suggesting a holistic framework for understanding healthcare services leadership competence - a critical interpretive synthesis.",
"Healthcare providers are under pressure due to increasing and more complex demands for services. Increased pressure on budgets and human resources adds to an... | [
[
"39955842",
"Hormones, brain and behavior in birds: The Lehrman legacy.",
"This short essay is based on the presentation I gave at the meeting of the Society of Behavioral Neuroendocrinology held in Tours, France in June 2023 when I received the Lehrman award for career achievement. I conducted my PhD... |
38412004 | Characteristics of Hepatitis B Virus, Hepatitis C Virus, and Syphilis Coinfection in People With HIV/AIDS Contracted Through Different Sources: Retrospective Study. | The burden of hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis coinfections remains disproportionately high among people living with HIV/AIDS. Hubei province is located in central China, where there are distinct regional characteristics of the distribution of people living with HIV/AIDS acquired via diver... | [
[
"37795953",
"Diagnostic value of cerebrospinal fluid chemokine c-x-c motif ligand 13 for neurosyphilis: A systematic review and meta-analysis.",
"The diagnostic value of cerebrospinal fluid chemokine c-x-c motif ligand 13 (CSF CXCL13) for neurosyphilis was assessed by meta-analysis in this study. PubM... | [
[
"39391051",
"Deciphering Proteomic Expression in Inflammatory Disorders: A Mass Spectrometry Exploration Comparing Infectious, Noninfectious, and Traumatic Brain Injuries in Human Cerebrospinal Fluid.",
"The central nervous system (CNS) evokes a complex inflammatory response to injury. Inflammatory ca... |
40102551 | Hair cortisol as a marker of stress in mild traumatic brain injury: a challenging measure. | Cortisol is released through activation of the hypothalamic-pituitary-adrenal axis by physiological and psychological stressors, such as mild traumatic brain injury (mTBI). This hormone is accumulated in hair over longer periods of time, reflecting both acute and chronic forms of stress, allowing for retrospective anal... | [
[
"34054681",
"Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions.",
"We aimed to detect the possible accelerating role of previous traumatic brain injury (TBI) exposures on the onset of later cognitive decline assessed across different brain diseases. We analyze... | [
[
"39333695",
"Exploring the structure and dynamics of soft and hard cuticle of Bombyx mori using solid-state NMR techniques.",
"This study conducts a comprehensive analysis and comparison of Bombyx mori cuticles across different developmental stages, ranging from larval to adult, utilizing advanced sol... |
20883353 | Identification of red-green colour deficiency: sensitivity of the Ishihara and American Optical Company (Hard, Rand and Rittler) pseudo-isochromatic plates to identify slight anomalous trichromatism. | Screening sensitivity, based on a specific number of errors, of the Ishihara plates and of the American Optical Company (Hardy, Rand and Rittler) plates (HRR plates) was determined by reviewing data obtained for 486 male anomalous trichromats identified and classified with the Nagel anomaloscope. Data were obtained for... | [
[
"15252758",
"Signatures of selection and gene conversion associated with human color vision variation.",
"Trichromatic color vision in humans results from the combination of red, green, and blue photopigment opsins. Although color vision genes have been the targets of active molecular and psychophysic... | [
[
"20428887",
"The role of anterior insular cortex in social emotions.",
"Functional neuroimaging investigations in the fields of social neuroscience and neuroeconomics indicate that the anterior insular cortex (AI) is consistently involved in empathy, compassion, and interpersonal phenomena such as fai... |
28774650 | Rapid anatomical brain imaging using spiral acquisition and an expanded signal model. | We report the deployment of spiral acquisition for high-resolution structural imaging at 7T. Long spiral readouts are rendered manageable by an expanded signal model including static off-resonance and B<sub | [
[
"11810678",
"Elimination of Nyquist ghosting caused by read-out to phase-encode gradient cross-terms in EPI.",
"Echo-planar imaging (EPI) commonly suffers from ghosting artifacts caused by zero- or first-order phase differences between the odd and even echoes that constitute an EPI dataset. Small-bore... | [
[
"29872302",
"Valium without dependence? Individual GABA(A) receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects.",
"Benzodiazepines are one of the most prescribed medications as first-line treatment of anxiety, insomnia, and epilepsy around the world. Over ... |
24711394 | Homeostasis of functional maps in active dendrites emerges in the absence of individual channelostasis. | The maintenance of ion channel homeostasis, or channelostasis, is a complex puzzle in neurons with extensive dendritic arborization, encompassing a combinatorial diversity of proteins that encode these channels and their auxiliary subunits, their localization profiles, and associated signaling machinery. Despite this, ... | [
[
"12417672",
"Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task.",
"Decisions about the visual world can take time to form, especially when information is unreliable. We studied the neural correlate of gradual decision formation by recordin... | [
[
"23893323",
"An atypical case of SCN9A mutation presenting with global motor delay and a severe pain disorder.",
"Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness o... |
40056182 | Review of 7T MRI imaging of pituitary microadenomas: are we there yet? | 7T MRI imaging of the pituitary gland is an emerging technique. The purpose of this article is to review the current status of the 7T MRI of the pituitary gland, particularly in the context of pituitary microadenoma pathology. We will discuss technical challenges and parallel transmission opportunities.</AbstractText F... | [
[
"19449383",
"A transmit/receive system for magnetic field monitoring of in vivo MRI.",
"Magnetic field monitoring with NMR probes has recently been introduced as a means of measuring the actual spatiotemporal magnetic field evolution during individual MR scans. Receive-only NMR probes as used thus far... | [
[
"40503482",
"Magnetic resonance defecography assessment of obstructed defecation syndrome in patients with chronic constipation in a tertiary care hospital.",
"Obstructed defecation syndrome (ODS) is a subtype of constipation that is considered one of the major pelvic floor dysfunctions affecting the ... |
40166768 | Crossing the chasm: engaging Black men survivors of gun violence in mental health services. | Despite being high risk for post-traumatic stress disorder, Black men survivors of gun violence, and particularly young men aged 18-24, seldom participate in mental health services after injury. The aim of this study was to identify barriers to participation in mental health services for this population.</AbstractText ... | [
[
"25863813",
"Cerebellar Contribution to Context Processing in Extinction Learning and Recall.",
"Whereas acquisition of new associations is considered largely independent of the context, context dependency is a hallmark of extinction of the learned associations. The hippocampus and the prefrontal cort... | [
[
"40412529",
"Surgical Nerve Decompression at Lower Extremity for Diabetic Neuropathy: A Systematic Review and Meta-Analysis of Time-Dependent Pain, Sensory Recovery, Amputation, Ulcer Recurrence, and Balance.",
"This systematic review and meta-analysis evaluated the efficacy of surgical nerve decompre... |
39570907 | Functional near-infrared spectrometry for auditory speech stimuli in cochlear implant users: a systematic literature review. | This study aims to identify the acquisition features of functional near-infrared spectroscopy (fNIRS) in cochlear implant users.</AbstractText A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, LILACS, Web of... | [
[
"25151264",
"Dimensionality reduction for large-scale neural recordings.",
"Most sensory, cognitive and motor functions depend on the interactions of many neurons. In recent years, there has been rapid development and increasing use of technologies for recording from large numbers of neurons, either s... | [
[
"38159612",
"Association Between Quality of Life and Neurogenic Bowel Symptoms by Bowel Management Program in Spina Bifida.",
"To compare differences in bowel-specific quality of life (QOL), overall qQOL, and neurogenic bowel dysfunction (NBD) severity by bowel management program in patients with spin... |
40715419 | Inter- and intra-bacterial strain diversity remains the "elephant in the (living) room". | Acinetobacter baumannii is an opportunistic Gram-negative bacterial pathogen responsible for severe nosocomial infections worldwide. Resistance to last-resort antibiotics causes A. baumannii to be ranked as a top priority for the research and development of new antibiotics by the WHO and an urgent threat to public heal... | [
[
"33495315",
"Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer.",
"Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations. PDAC CAFs are... | [
[
"40413347",
"Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.",
"Type 1 Diabetes Mellitus (T1DM) progression has a direct impact on brain microstructural integrity and typical functional organization from the early stages of neurodevelo... |
40461172 | Medical management of ADHD in adults: part 2. | Methylphenidate and lisdexamfetamine are recommended as first-line pharmacological treatment options for adults with attention deficit hyperactivity disorder (ADHD). Formulations of methylphenidate can generally be classified into three groups according to their duration of action: one group lasts 12 hours, another gro... | [
[
"39376970",
"Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study.",
"In previous observational studies and meta-analyses, childhood attention deficit hyperactivity disorder (ADHD) is found to have a significant association with scre... | [
[
"40737393",
"The β(2)-adrenergic receptor (Adrb2) entrains circadian gene oscillation and CD8(+) T cell differentiation in response to virus infection.",
"Adaptive immune cells are regulated by circadian rhythms both under steady state conditions and during responses to infection. Cytolytic CD8<sup"
... |
39853319 | Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis. | Behavioral addictions (BAs) represent complex and multifaceted disorders often associated with maladaptive neural alteration. To deepen our understanding of the essence of BAs, this study focuses on the neural mechanisms underlying its three stages: reward seeking, self-control, and decision-making. The aim of the curr... | [
[
"26802508",
"A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play.",
"Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with de... | [
[
"39804020",
"Step Width Haptic Feedback for Gait Stability in Spinocerebellar Ataxia: Preliminary Results.",
"Wider step width and lower step-to-step variability are linked to improved gait stability and reduced fall risk. It is unclear if patients with spinocerebellar ataxia (SCA) can learn to adjust... |
29471227 | The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study. | Abuse of methamphetamine (MA) is a global health concern. Previous <sup Adults with chronic MA dependence (n = 31) and healthy controls (n = 22) were recruited. Two-dimensional chemical shift <sup Acute MAA showed lower n-acetyl-aspartate (NAA) and n-acetyl-aspartate with n-acetyl-aspartyl-g... | [
[
"24897622",
"μHigh resolution-magic-angle spinning NMR spectroscopy for metabolic phenotyping of Caenorhabditis elegans.",
"Analysis of model organisms, such as the submillimeter-size Caenorhabditis elegans, plays a central role in understanding biological functions across species and in characterizin... | [
[
"29905724",
"Energy density and energy flux in the focus of an optical vortex: reverse flux of light energy.",
"Using the Richards-Wolf formulas for an arbitrary circularly polarized optical vortex with an integer topological charge m, we obtain explicit expressions for all components of the electric ... |
40385881 | Post-thalamotomy Changes Mimicking Cavernous Malformations on MRI: A Case Report of a Historical Surgical Treatment. | The patient was a 65-year-old man with cervical dystonia onset at age six who had been treated at Chiba University Hospital. He was diagnosed and followed up with cavernous malformations and chronic cerebral infarctions based on an MRI. However, during the re-evaluation of MRI, lesions with low signal intensity (SI) co... | [
[
"21666131",
"Abnormal structure-function relationship in spasmodic dysphonia.",
"Spasmodic dysphonia (SD) is a primary focal dystonia characterized by involuntary spasms in the laryngeal muscles during speech production. Although recent studies have found abnormal brain function and white matter organ... | [
[
"40446445",
"Optimizing mesenchymal stromal cells priming strategies for tailored effects on the secretome.",
"Mesenchymal stromal cells (MSCs) have emerged as a promising tool in regenerative medicine, with recent focus shifting towards their secretome as a cell-free therapeutic approach. This study ... |
35317746 | Comparative study of vestibular projection pathway connectivity in cerebellar injury patients and healthy adults. | Cerebellar injury can not only cause gait and postural instability, nystagmus, and vertigo but also affect the vestibular system. However, changes in connectivity regarding the vestibular projection pathway after cerebellar injury have not yet been reported. Therefore, in the current study, we investigated differences ... | [
[
"29129392",
"Targeting Obesity and Cachexia: Identification of the GFRAL Receptor-MIC-1/GDF15 Pathway.",
"Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFβ) superfamily cytokine implicated in biological and disease pro... | [
[
"34449006",
"Exploring the Concept of Spiritual Sensitivity from the Perspectives of Healthcare Providers in Iran.",
"Spiritual sensitivity (SS) is defined as attention to the available spiritual values in a conflicting situation and awareness of one's roles and responsibilities in that situation. It ... |
37437821 | LPS priming before plaque deposition impedes microglial activation and restrains Aβ pathology in the 5xFAD mouse model of Alzheimer's disease. | Microglia have an innate immunity memory (IIM) with divergent functions in different animal models of neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by chronic neuroinflammation, neurodegeneration, tau tangles and β-amyloid (Aβ) deposition. Systemic inflammation has been... | [
[
"27766433",
"Midbrain Synchrony to Envelope Structure Supports Behavioral Sensitivity to Single-Formant Vowel-Like Sounds in Noise.",
"Vowels make a strong contribution to speech perception under natural conditions. Vowels are encoded in the auditory nerve primarily through neural synchrony to tempora... | [
[
"36808307",
"Neurobiological correlates and attenuated positive social intention attribution during laughter perception associated with degree of autistic traits.",
"Laughter plays an important role in group formation, signaling social belongingness by indicating a positive or negative social intentio... |
36770411 | Towards the Standardization of Photothermal Measurements of Iron Oxide Nanoparticles in Two Biological Windows. | A systematic study on laser-induced heating carried out in two biological windows (800 nm and 1053 nm) for Fe<sub | [
[
"34411327",
"The Coax Dipole: A fully flexible coaxial cable dipole antenna with flattened current distribution for body imaging at 7 Tesla.",
"The coax dipole antenna, a flexible antenna for body imaging at 7T is presented. Similar to the high impedance coil, this coaxial cable antenna is fed on the ... | [
[
"37738741",
"Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes.",
"Intracortical microelectrodes that can record and stimulate brain activity have become a valuable technique for basic science research and clinical applications. However, long-term... |
37954642 | Case series: Intraoperative neuromonitoring and angiography in the surgical treatment of vascular malformations. | In the surgical treatment of cerebral vascular malformations, e.g., aneurysms and arteriovenous malformations, the risk of ischemic complications is 6.7%, and a residual aneurysm is possible in 5.2% of these cases. Ischemic lesions can result in permanent neurological deficits, and a residual aneurysm can lead to the r... | [
[
"25624933",
"Scalp arteriovenous malformations in young.",
"Scalp arteriovenous malformations are an exceptional group of vascular lesions with curious presentations and an elusive natural history. Their detection in the pediatric population is a rarer occurrence. We discuss our experience with five c... | [
[
"36427671",
"The functional connectivity between left insula and left medial superior frontal gyrus underlying the relationship between rumination and procrastination.",
"Procrastination is regarded as a prevalent problematic behavior that impairs people's physical and mental health. Although previous... |
40396767 | Case series of CT-fusion and real-time US-guidance in percutaneous RF thermocoagulation for trigeminal rhizotomy. | This case series evaluates the feasibility, safety, and efficacy of real-time computed tomography fusion with ultrasound guidance (CTF-USG) in percutaneous radiofrequency thermocoagulation (RFT) for trigeminal rhizotomy. Traditional imaging modalities such as CT and fluoroscopy lack real-time visualization, increasing ... | [
[
"17274022",
"Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI.",
"We examined the neural substrate of motor response inhibition and performance monitoring in the stop signal task (SST) using event-related functional magnetic resonance imag... | [
[
"39810626",
"Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations.",
"Temporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a me... |
38152804 | Evaluation of 'Normal' Cognitive Functions and Correlation With MRI Volumetry: Towards a Definition of Vascular Cognitive Impairment. | Introduction It is important to establish criteria to define vascular cognitive impairment (VCI) in India as VCI is an image-based diagnosis and magnetic resonance imaging (MRI) changes resulting from age with prevalent vascular risk factors may confound MRI interpretation. The objective of this study was to establish ... | [
[
"30962628",
"Working memory revived in older adults by synchronizing rhythmic brain circuits.",
"Understanding normal brain aging and developing methods to maintain or improve cognition in older adults are major goals of fundamental and translational neuroscience. Here we show a core feature of cognit... | [
[
"36748121",
"Detecting and treating the protean manifestations of diabetic autonomic neuropathy.",
"The manifestations of diabetic autonomic neuropathy (DAN) are protean and clinically involve multiple systems, including the cardiovascular system, the gastrointestinal system, the genitourinary system ... |
40776133 | Stroke Cohort Construction Using an Automated Clinical Data Collection System: An Experience of a Single Cerebrovascular Specialty Hospital in South Korea. | The growing volume of clinical data necessitates efficient management of Electronic Health Records (EHR) data. Traditional labor-intensive EHR management methods have led to significant risks, including high error rates and data omissions. This study modified and developed EHR templates focusing on key cohort-specific ... | [
[
"24345399",
"Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study.",
"The global burden of atrial fibrillation (AF) is unknown.</AbstractText We systematically reviewed population-based studies of AF published from 1980 to 2010 from the 21 Global Burden of Disease regio... | [
[
"39481376",
"Combinatorial transcription factor binding encodes cis-regulatory wiring of mouse forebrain GABAergic neurogenesis.",
"Transcription factors (TFs) bind combinatorially to cis-regulatory elements, orchestrating transcriptional programs. Although studies of chromatin state and chromosomal i... |
40783178 | Live-attenuated Toxoplasma gondii PruΔpp2a-c mutant elicits protective immunity against toxoplasmosis in mice and cats. | Toxoplasma gondii is a zoonotic protozoan pathogen capable of infecting humans and nearly all warm-blooded animals, and causing substantial economic losses to the livestock industry. Developing an effective vaccine against T. gondii remains an urgent priority for controlling the spread of this zoonotic parasite. In thi... | [
[
"27432990",
"Dynamic neural activity during stress signals resilient coping.",
"Active coping underlies a healthy stress response, but neural processes supporting such resilient coping are not well-known. Using a brief, sustained exposure paradigm contrasting highly stressful, threatening, and violent... | [
[
"40037512",
"A novel ferroptosis inhibitor phenothiazine derivative reduces cell death and alleviates neurological impairments after cerebral hemorrhage.",
"The precise etiology of brain injury induced by intracerebral hemorrhage (ICH) remains unclear. Currently, there are no effective therapeutic opt... |
38195249 | Treatment outcomes for ARUBA-eligible brain arteriovenous malformations: a comparison of real-world data from the NVQI-QOD AVM registry with the ARUBA trial. | Significant controversy exists about the management of unruptured cerebral arteriovenous malformations (AVMs). Results from A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) suggested that intervention increases the risk of stroke/death compared with medical management. However, numerous study ... | [
[
"26156615",
"Management of a solitary pulmonary arteriovenous malformation by video-assisted thoracoscopic surgery and anatomic lingula resection: video and review.",
"Pulmonary arteriovenous malformations are abnormal communications between the pulmonary arterial and venous vasculature leading to a r... | [
[
"39595016",
"The Impact of Virtual Reality as a Rehabilitation Method Using TRAVEE System on Functional Outcomes and Disability in Stroke Patients: A Pilot Study.",
"Stroke is the third leading cause of disability. Virtual reality (VR) has shown promising results in post-stroke rehabilitation. The VR ... |
40371132 | Neural mechanisms of CALM intervention to improve CRCI in breast cancer survivors: an fMRI-based study. | Managing Cancer and Living Meaningfully (CALM) intervention's impact on chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCs) was investigated through resting-state functional magnetic resonance imaging (rs-fMRI) to elucidate the underlying neural mechanisms involved.</AbstractText 68 BCs we... | [
[
"33308061",
"Why do imagery and perception look and feel so different?",
"Despite the past few decades of research providing convincing evidence of the similarities in function and neural mechanisms between imagery and perception, for most of us, the experience of the two are undeniably different, why... | [
[
"39707024",
"Mechanical signaling through membrane tension induces somal translocation during neuronal migration.",
"Neurons migrate in a saltatory manner by repeating two distinct steps: extension of the leading process and translocation of the cell body. The former step is critical for determining t... |
37160674 | Antitrust as a Guardrail for Socially Responsible Neurotechnology Design. | The neurotechnology sector is likely to develop under pressure towards commercialized, nonmedical products and may also undergo market consolidation. This possibility raises ethical, social, and policy concerns about the future responsibility of neurotechnology innovators and companies for high-consequence design decis... | [
[
"24904404",
"Decoding spectrotemporal features of overt and covert speech from the human cortex.",
"Auditory perception and auditory imagery have been shown to activate overlapping brain regions. We hypothesized that these phenomena also share a common underlying neural representation. To assess this,... | [
[
"36889873",
"Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring.",
"Although implantable cardioverter-defibrillator (ICD) therapies are associated with increased morbidity and mortality, the prediction of malignant ventricular arrhythmias has remained elusive.</AbstractText... |
37756592 | Attention-based generative adversarial networks improve prognostic outcome prediction of cancer from multimodal data. | The prediction of prognostic outcome is critical for the development of efficient cancer therapeutics and potential personalized medicine. However, due to the heterogeneity and diversity of multimodal data of cancer, data integration and feature selection remain a challenge for prognostic outcome prediction. We propose... | [
[
"32300047",
"Categorical Signaling of the Strongest Stimulus by an Inhibitory Midbrain Nucleus.",
"The nucleus isthmi pars magnocellularis (Imc), a group of inhibitory neurons in the midbrain tegmentum, is a critical component of the spatial selection network in the vertebrate midbrain. It delivers lo... | [
[
"37043357",
"Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone.",
"The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSC... |
39387957 | Advanced imaging reveals enhanced malignancy in glioblastomas involving the subventricular zone: evidence of increased infiltrative growth and perfusion. | Glioblastoma's infiltrative growth and heterogeneity are influenced by neural, molecular, genetic, and immunological factors, with the precise origin of these tumors remaining elusive. Neurogenic zones might serve as the tumor stem cells' nest, with tumors in contact with these zones exhibiting worse outcomes and more ... | [
[
"26798224",
"Pre-Operative Perfusion Skewness and Kurtosis Are Potential Predictors of Progression-Free Survival after Partial Resection of Newly Diagnosed Glioblastoma.",
"To determine whether pre-operative perfusion skewness and kurtosis derived from normalized cerebral blood volume (nCBV) histogram... | [
[
"40726664",
"A retrospective observational study of clinical and electrophysiological types of Guillain-Barre syndrome from Delhi.",
"To understand the demographic characteristics (age, sex and comorbidities), distribution of electrodiagnostic subtypes, and severity and prognosis of Guillain-Barre syn... |
39163384 | Childhood family socioeconomic status is linked to adult brain electrophysiology. | A large body of research has linked childhood family socioeconomic status (SES) to neurodevelopment in childhood and adolescence. However, it remains unclear to what extent childhood family SES relates to brain functioning in adulthood. To address this gap, the present study investigated the associations between retros... | [
[
"15131523",
"The role of GABA in the pathophysiology and treatment of anxiety disorders.",
"Mechanisms underlying the pathological characteristics of the various anxiety disorders have yet to be fully elucidated. One of the most widely accepted mediators known to play a central role in the pathophysio... | [
[
"38472551",
"Ocrelizumab use in multiple sclerosis: a real-world experience in a changing therapeutic scenario.",
"CD20-depleting therapies are a real milestone in the treatment of multiple sclerosis (MS). This study examined the ocrelizumab (OCR) use in patients with primary progressive (PP) and... |
40011296 | Pyrrolidine Dithiocarbamate Ameliorates Sepsis-Associated Encephalopathy by Inhibiting Autophagy and Inflammation in the Brain. | Sepsis-associated encephalopathy (SAE) is common and has poor clinical outcome. Sepsis increases autophagy in the brain. This study was designed to determine the role of autophagy on SAE including the brain structures related to learning and memory and the effects of pyrrolidine dithiocarbamate (PDTC), an anti-inflamma... | [
[
"37331262",
"Treatment outcomes of Veteran men in a comprehensive dialectical behavior therapy program: Characterizing sex differences in symptom trajectories.",
"Dialectical Behavior Therapy (DBT) is one of the primary psychosocial treatments for reducing suicidal behaviors and improving psychosocial... | [
[
"40543407",
"Exploring gastrocnemius medialis behavior during gait in children with cerebral palsy across different gait patterns.",
"Children with spastic cerebral palsy show varied gait patterns and muscle morphological alterations. We explored gastrocnemius medialis behavior during gait in typicall... |
35065321 | Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways. | Mercuric chloride (HgCl<sub | [
[
"3025747",
"A new mechanism for induced vitamin D deficiency in calcium deprivation.",
"Synthesis of vitamin D in the skin in response to ultraviolet light is the main determinant of vitamin D status in man and it is therefore surprising that rickets and osteomalacia, clinical signs of vitamin D defic... | [
[
"36685218",
"Sources of residual autocorrelation in multiband task fMRI and strategies for effective mitigation.",
"Analysis of task fMRI studies is typically based on using ordinary least squares within a voxel- or vertex-wise linear regression framework known as the general linear model. This use pr... |
34324976 | Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T. | Mapping mesoscopic cortical functional units such as columns or laminae is increasingly pursued by ultra-high field (UHF) functional magnetic resonance imaging (fMRI). The most popular approach for high-resolution fMRI is currently gradient-echo (GE) blood oxygenation level-dependent (BOLD) fMRI. However, its spatial a... | [
[
"32936488",
"Segmented K-space blipped-controlled aliasing in parallel imaging for high spatiotemporal resolution EPI.",
"A segmented k-space blipped-controlled aliasing in parallel imaging (skipped-CAIPI) sampling strategy for EPI is proposed, which allows for a flexible choice of EPI factor and phas... | [
[
"23103517",
"Towards a neural circuit model of verbal humor processing: an fMRI study of the neural substrates of incongruity detection and resolution.",
"The present study builds on our previous study within the framework of Wyer and Collin's comprehension-elaboration theory of humor processing. In t... |
30605083 | Adaptive Matching Transmitter With Dual-Band Antenna for Intraoral Tongue Drive System. | The intraoral Tongue Drive System (iTDS) is a wireless assistive technology that detects users' voluntary tongue gestures, and converts them to user-defined commands, enabling them to access computers and navigate powered wheelchairs. In this paper, we presented a transmitter (Tx) with adaptive matching and three bands... | [
[
"23556919",
"A prototype MR insertable brain PET using tileable GAPD arrays.",
"The aim of this study was to develop a prototype magnetic resonance (MR)-compatible positron emission tomography (PET) that can be inserted into a MR imager and that allows simultaneous PET and MR imaging of the human brai... | [
[
"29446125",
"Feasibility of high spatiotemporal resolution for an abbreviated 3D radial breast MRI protocol.",
"To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam.</Abs... |
39730017 | Forsythoside B ameliorates neuroinflammation via inhibiting NLRP3 inflammasome of glial cells in experimental autoimmune encephalomyelitis mice. | Neuroinflammation mediated by glial cells plays a crucial role in demyelination in experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS) model. Forsythoside B (FTS·B), a natural phenylethanoid glycoside isolated from the dried fruits and leaves of Forsythia suspensa (Thunb.) Vahl, has been fou... | [
[
"31740269",
"Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration.",
"Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of... | [
[
"39934999",
"MacaqueNet: Advancing comparative behavioural research through large-scale collaboration.",
"There is a vast and ever-accumulating amount of behavioural data on individually recognised animals, an incredible resource to shed light on the ecological and evolutionary drivers of variation in... |
16196033 | Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. | Chemokines and their receptors are well described in the immune system, where they promote cell migration and activation. In the central nervous system, chemokine has been implicated in neuroinflammatory processes. However, an increasing number of evidence suggests that they have regulatory functions in the normal nerv... | [
[
"36857176",
"Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.",
"Kainate receptors (KARs) are a subtype of ionotropic glutamate receptors that control synaptic transmission in the central nervous system and are implicated in neurological, ... | [
[
"38010204",
"Associations between white matter integrity of the cingulum bundle, surrounding gray matter regions, and cognition across the dementia continuum.",
"Previous Alzheimer's disease and related dementias (AD/ADRD) research studies have illustrated the significance of studying alterations in w... |
34132175 | Creutzfeldt-Jakob disease in pregnancy: the use of modified RT-QuIC to determine infectivity in placental tissues. | Sporadic Creutzfeldt-Jakob Disease (sCJD) rarely affects women of childbearing age. There is currently no evidence of vertical transmission. Given the biosafety implications of performing Caesarean sections (C-section) in these patients, we used sensitive real-time quaking-induced conversion (RT-QuIC) assays to test fo... | [
[
"29186501",
"The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.",
"Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins. Misfolding of 1 protein in aged brains often is accompanied by the misfolding of other p... | [
[
"33143627",
"Diabetes and Its Complications: Therapies Available, Anticipated and Aspired.",
"Worldwide, diabetes ranks among the ten leading causes of mortality. Prevalence of diabetes is growing rapidly in low and middle income countries. It is a progressive disease leading to serious co-morbidities... |
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