anchor_id stringlengths 8 8 | anchor_title stringlengths 9 621 | anchor_abstract stringlengths 2 32.3k | positive_pool listlengths 5 5 | negative_pool listlengths 5 5 |
|---|---|---|---|---|
40498790 | Upper Limb Apraxia Is Related to Role Participation Among Patients With Mild to Moderate Stroke. | Poststroke, patients often experience decreased role participation, partially because of cognitive impairment. However, the potential relationship between upper limb apraxia (ULA), a cognitive dysfunction, and role participation remains unclear.</AbstractText To evaluate whether ULA is related to role participation among patients with mild to moderate stroke.</AbstractText Cross-sectional study.</AbstractText Randomly selected Spanish public primary care centers.</AbstractText One hundred fifty-three patients with mild to moderate poststroke.</AbstractText Role participation was assessed with the Role Checklist; ULA, with the TULIA Apraxia test and the ADL Observations scale. ULA construct included the components of nonsymbolic imitation, intransitive imitation, transitive imitation, nonsymbolic pantomime, intransitive pantomime, transitive pantomime, and praxis function in daily life activities. Regression analyses were conducted to assess the potential relationship between ULA and role participation.</AbstractText Transitive pantomime explained 20.5% of the variance of the current level of role participation, R2 = .205, F(3, 152) = 12.795, p < .001. Nonsymbolic imitation and transitive imitation explained 15.8% of the variance in changes in role participation after stroke, R2 = .158, F(4, 152) = 6.957, p < .001. Intransitive pantomime accounted for 17.8% of the variance in expectations for future role participation, R2 = .178, F(3, 152) = 10.776, p < .001. Nonsymbolic imitation and intransitive pantomime explained 16.2% of the variance of the assigned value to role participation, R2 = .162, F(4, 152) = 7.170, p < .01.</AbstractText ULA is related to role participation after mild to moderate stroke. These findings serve as the foundation for designing and developing novel clinical interventions in occupational therapy. Plain-Language Summary: After a stroke, patients often experience difficulties participating in roles that provide a sense of purpose in daily activities. This decrease in participation is partly because of cognitive factors. Upper limb apraxia (ULA) is a cognitive sequela of stroke that hinders the ability to perform deliberate and essential movements. ULA can affect daily life by posing challenges in the execution of daily tasks and activities, which can affect a person's independence, participation, and community reintegration. Because ULA is a cognitive dysfunction that affects intentional movements, this study investigated the potential relationship between ULA and role participation. Based on the evaluation of 153 patients with mild to moderate poststroke, the results revealed that ULA is associated with role participation after a stroke. These findings serve as the foundation for occupational therapists to design and develop novel clinical interventions.</AbstractText | [
[
"34104033",
"Blue-Light Therapy Strengthens Resting-State Effective Connectivity within Default-Mode Network after Mild TBI.",
"Emerging evidence suggests that post concussive symptoms, including mood changes, may be improved through morning blue-wavelength light therapy (BLT). However, the neurobiolo... | [
[
"40710562",
"Understanding the Metabolic Effects of Surgically Induced Renal Ischemia in Humans: A Temporal Approach.",
"<b"
],
[
"40480414",
"Flexible beam-based microelectrode arrays integrated with oriented nanofiber scaffolds for electrophysiological monitoring of cardiac tissue.",
... |
40509179 | Towards Cytotoxic Derivatives of Cafestol. | This study focuses on the extraction, characterization, and biological evaluation of diterpenes from green coffee beans, specifically, cafestol and kahweol. These compounds, known for their potential health benefits, were isolated via optimized extraction and saponification processes. Separation was achieved using silver nitrate-impregnated silica gel, and structural elucidation was performed through advanced 1D and 2D NMR techniques, including HSQC, HMBC, and (IN)ADEQUATE. Due to kahweol's instability, the research prioritized cafestol for the synthesis of rhodamine B conjugates. Initial ester-linked conjugates proved unstable, prompting the development of more robust derivatives through amide linkage strategies and further functionalization via acetylation and oxidation reactions. Some oxidation methods led to furan ring cleavage, impacting structural integrity. Selected compounds were tested for cytotoxicity using SRB assays on human tumor cell lines (MCF7, A2780) and non-malignant fibroblasts (NIH 3T3). While the parent diterpenes and many derivatives showed minimal activity, several cafestol-rhodamine B conjugates demonstrated notable cytotoxic effects. Compound <b | [
[
"27401805",
"Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner.",
"Positron emission tomography (PET) with <sup"
],
[
"30292731",
"Sleep Disorders.",
"Sleep disorders are frequent and can have serious consequences on patients' ... | [
[
"40647442",
"The Role of ENHO in Pancreatic Adenocarcinoma: A Bioinformatics Approach.",
"Pancreatic adenocarcinoma (PAAD) is an aggressive subtype of pancreatic cancer that is estimated to have a 5-year overall survival rate of only 13%. Most patients present with advanced disease with unpredictable ... |
34519480 | Antioxidative and Angiogenic Hyaluronic Acid-Based Hydrogel for the Treatment of Peripheral Artery Disease. | Peripheral arterial disease (PAD) is a progressive atherosclerotic disorder characterized by blockages of the arteries supplying the lower extremities. Ischemia initiates oxidative damage and mitochondrial dysfunction in the legs of PAD patients, causing injury to the tissues of the leg, significant decline in walking performance, leg pain while walking, and in the most severe cases, nonhealing ulcers and gangrene. Current clinical trials based on cells/stem cells, the trophic factor, or gene therapy systems have shown some promising results for the treatment of PAD. Biomaterial matrices have been explored in animal models of PAD to enhance these therapies. However, current biomaterial approaches have not fully met the essential requirements for minimally invasive intramuscular delivery to the leg. Ideally, a biomaterial should present properties to ameliorate oxidative stress/damage and failure of angiogenesis. Recently, we have created a thermosensitive hyaluronic acid (HA) hydrogel with antioxidant capacity and skeletal muscle-matching stiffness. Here, we further optimized HA hydrogels with the cell adhesion peptide RGD to facilitate the development of vascular-like structures <i | [
[
"26282581",
"GABAB receptor-mediated feed-forward circuit dysfunction in the mouse model of fragile X syndrome.",
"Cortico-hippocampal feed-forward circuits formed by the temporoammonic (TA) pathway exhibit a marked increase in excitation/inhibition ratio and abnormal spike modulation functions in Fmr... | [
[
"33430634",
"Stroke Imaging Selection Modality and Endovascular Therapy Outcomes in the Early and Extended Time Windows.",
"Advanced imaging has been increasingly used for patient selection in endovascular stroke therapy. The impact of imaging selection modality on endovascular stroke therapy clinical... |
29340183 | Action observation training to improve motor function recovery: a systematic review. | Following the discovery of Mirror Neuron System (MNS), Action Observation Training (AOT) has become an emerging rehabilitation tool to improve motor functions both in neurologic and orthopedic pathologies. The aim of this study is to present the state of the art on the use of AOT in experimental studies to improve motor function recovery in any disease. The research was performed in PubMed, PEDro, Embase, CINAHL and Cochrane Central Register of Controlled Trials (last search July 2015). Randomized controlled trials (RCTs) that analyse efficacy of AOT for recovery of motor functions, regardless of the kind of disease, were retrieved. The validity of the included studies was assessed using the Cochrane Collaboration tool for evaluating risk of bias. Twenty RCTs were eligible. Four studies showed AOT efficacy in improving upper limb functional recovery in participants with chronic stroke, two studies in sub-acute ones and one in acute ones. Six articles suggested its effectiveness on walking performance in chronic stroke individuals, and three of them also suggested an efficacy in improving balance. The use of AOT was also recommended in individuals with Parkinson's disease to improve autonomy in activities of daily living, to improve spontaneous movement rate of self-paced finger movements and to reduce freezing of gait. Other two studies also indicated that AOT improves upper limb motor function in children with cerebral palsy. The last two studies, showed the efficacy of AOT in improving motor recovery in postsurgical orthopedic participants. Overall methodological quality of the considered studies was medium. The majority of analyzed studies suggest the efficacy of AOT, in addition to conventional physiotherapy, to improve motor function recovery in individuals with neurological and orthopedic diseases. However, the application of AOT is very heterogeneous in terms of diseases and outcome measures assessed, which makes it difficult to reach, to date, any conclusion that might influence clinical practice.</AbstractText | [
[
"29361441",
"Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review.",
"Electrical stimulation of the auricular branch of the vagus nerve (ABVN) via transcutaneous auricular vagus nerve sti... | [
[
"26033541",
"Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling.",
"Embryonic stem cells (ESCs) possess pluripotency, which is the capacity of cells to differentiate into all lineages of the mature organism. Increasing evidence suggests that the pluri... |
39560584 | Mitochondrial related Mendelian randomization identifies causal associations between metabolic disorders and childhood neurodevelopmental disorders. | Childhood neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder, and Tourette syndrome, are a predominant cause of health-related disabilities in children and adolescents. Nevertheless, disease biomarkers are still limited. The aim of this study was to evaluate the potential, causal relationship between mitochondrial DNA copy number (mtDNA-CN), metabolic disorders, and childhood NDDs using the two-sample Mendelian randomization (MR) method. Genetic associations with mtDNA-CN, disorders of lipoprotein metabolism, and disorders of iron metabolism were selected as exposures, and genome-wide association data from ASD, attention-deficit hyperactivity disorder, and Tourette syndrome were utilized as outcomes. Results of the study suggested that a high degree of disordered lipoprotein metabolism related increases in ASD risk result from a decrease in mtDNA-CN (disordered lipoprotein metabolism-mtDNA: inverse variance weighting β: -0.03, 95% confidence interval: -0.05 to -0.02, P = 2.08 × 10-5; mtDNA-CN-ASD: inverse variance weighting odds ratio: 0.83, 95% confidence interval: 0.69-0.99, P = .034). The research findings implied that mtDNA-CN can mediate disorders of lipoprotein metabolism, potentially influencing the development of ASD. The potential impact of the results of this study for the prevention and treatment of childhood NDDs warrants validation in robust randomized clinical trials.</AbstractText | [
[
"36447010",
"Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids.",
"Tourette Syndrome (TS) is a neuropsychiatric disorder thought to involve a reduction of basal ganglia (BG) interneurons and malfunctioning of the BG circuitry. However, whether interneurons fail to deve... | [
[
"37882378",
"The efficacy of oral corticoids in treating complex regional pain syndrome: A retrospective cohort study.",
"There is growing evidence supporting the role of inflammatory mechanisms in complex regional pain syndrome (CRPS). Corticoids, as most effective anti-inflammatory drugs, are widely... |
39999454 | Comorbid Guillain-Barré Syndrome and Tuberculosis: A Case Study and Global Perspective. | A 27-year-old man presented with a cough and progressive limb weakness. Initially diagnosed with pulmonary tuberculosis, he showed improvement in his cough after antituberculosis treatment (ATT). However, he subsequently developed worsening weakness and numbness in his lower limbs, leading to mobility loss and difficulty swallowing. A comprehensive diagnostic evaluation, including computed tomography of the lung, cranial magnetic resonance imaging, cerebrospinal fluid analysis, and electromyography, confirmed concurrent diagnoses of tuberculosis (TB) and Guillain-Barré syndrome (GBS). Treatment included immunoglobulin and corticosteroid therapy; however, his symptoms persisted, progressing to respiratory failure that required endotracheal intubation and plasma exchange therapy. After these interventions, his condition gradually improved, and he continued ATT, achieving a favorable recovery. A literature review identified 15 countries reporting cases of GBS associated with TB, with the highest incidence in India. Although most cases showed a positive prognosis, mortality rates were elevated in patients with comorbid TB and GBS compared to those with GBS alone.</AbstractText | [
[
"30310069",
"Immune-mediated neuropathies.",
"Since the discovery of an acute monophasic paralysis, later coined Guillain-Barré syndrome, almost 100 years ago, and the discovery of chronic, steroid-responsive polyneuropathy 50 years ago, the spectrum of immune-mediated polyneuropathies has broade... | [
[
"40436348",
"Gene therapy and nanomedicine for meningioma treatment.",
"Meningioma, a prevalent central nervous system (CNS) tumor, exhibits a broad spectrum of clinical behavior, ranging from benign to aggressive. Although surgical resection remains a viable treatment option for most cases, higher-gr... |
30401642 | Denervated mouse dentate granule cells adjust their excitatory but not inhibitory synapses following in vitro entorhinal cortex lesion. | Neurons adjust their synaptic strength in a homeostatic manner following changes in network activity and connectivity. While this form of plasticity has been studied in detail for excitatory synapses, homeostatic plasticity of inhibitory synapses remains not well-understood. In the present study, we employed entorhinal cortex lesion (ECL) of organotypic entorhino-hippocampal tissue cultures to test for homeostatic changes in GABAergic neurotransmission onto partially denervated dentate granule cells. Using single and paired whole-cell patch-clamp recordings, as well as immunostainings for synaptic markers, we find that excitatory synaptic strength is robustly increased 3 days post lesion (dpl), whereas GABAergic neurotransmission is not changed after denervation. Even under conditions of pharmacological inhibition of glutamatergic neurotransmission, which prevents neurons to compensate for the loss of input via excitatory synaptic scaling, down-scaling of GABAergic synapses does not emerge 3 days after denervation. We conclude that granule cells maintain structural and functional properties of GABAergic synapses even in the face of substantial changes in network connectivity. Hence, alterations in inhibitory neurotransmission, as seen in pathological brain states, may not simply reflect a homeostatic response to disconnection.</AbstractText | [
[
"11031127",
"The genomic action potential.",
"Neurons compute in part by integrating, on a time scale of milliseconds, many synaptic inputs and generating a digital output-the \"action potential\" of classic electrophysiology. Recent discoveries indicate that neurons also perform a second, much slower... | [
[
"30312809",
"Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging.",
"Intracortical myelin is a key determinant of neuronal synchrony and plasticity that underpin optimal brain function. Magnetic resonance imaging... |
37257216 | Prednisolone 20 mg vs 40 mg in complex regional pain syndrome type I: A randomized controlled trial. | High dose of corticosteroid has been found beneficial in complex regional pain syndrome type I (CRPS-I). We report the efficacy and safety of prednisolone 20 mg versus 40 mg in CRPS-I in an open label randomized controlled trial.</AbstractText The patients with CRPS-I of the shoulder joint with a CRPS score of ≥8 were included. Their demographic details, comorbidities, and underlying etiology were noted. The severity of CRPS was assessed using a 0-14 CRPS scale, the pain using a 0-10 Visual Analogue Scale (VAS), and sleep quality using a 0-10. Daily Sleep Interference Scale (DSIS). Patients were randomized to prednisolone 40 mg/day (group I) or 20 mg/day (group II) for 14 days, then tapered to 10 mg in group I and to 5 mg in group II by 1 month. Thereafter both groups received prednisolone 5 mg/day for 2 months. The primary outcome was a >50% reduction in VAS score, and secondary outcomes were a reduction in CRPS score, DSIS score, and adverse events.</AbstractText Fifty patients were included, and their baseline characteristics were comparable. At one month, all the patients had >50% reduction in the VAS score. The effect size was 0.38 (95% CI 0.93-0.20; p = 0.20). On the Kaplan-Mayer analysis, the improvement in the VAS score (Hazard ratio-1.43, 95 % CI-0.80-2.56, p = 0.22) and the CRPS score (HR-0.79,95 % CI-0.45-1.39; p = 0.41) was insignificant between the two groups. The DSIS score improved in group II (HR-1.85,95 % Cl-1.04-3.31,p = 0.04). Group I patients needed frequent adjustment of antidiabetic drugs (14 vs 6; p = 0.04).</AbstractText The efficacy of prednisolone 20 mg is not inferior to 40 mg in CRPS-I, and is safe in diabetic patients.</AbstractText This is an open label randomized controlled trial with small sample size without a placebo arm.</AbstractText | [
[
"40149508",
"Cannabinoids in Chronic Pain Management: A Review of the History, Efficacy, Applications, and Risks.",
"<b"
],
[
"40280127",
"The gut microbiota promotes pain in fibromyalgia.",
"Fibromyalgia is a prevalent syndrome characterized by widespread pain in the absence of eviden... | [
[
"36347341",
"The neural mechanism of non-phase-locked EEG activity in task switching.",
"Flexible switching between different tasks is an important cognitive ability for humans and it is often studied using the task-switching paradigm. Although the neural mechanisms of task switching have been extensi... |
40748959 | Orexin effect on physiological pulsations of the human brain. | Sleep promotes cerebrospinal fluid (CSF) to interstitial fluid (ISF) exchange in the brain facilitated by brain pulsations. Especially brain vasomotion and arterial pulsations modulated by noradrenaline drive the intracranial fluid dynamics. Narcolepsy type 1 (NT1) entails lessened orexinergic output to wake-promoting systems including the noradrenergic locus coeruleus. As arousal state and noradrenergic signaling affect CSF-ISF clearance, we chose patients with NT1 as a human orexin-targeted model of sleep-related pathology bridging the gap between healthy awake and sleep with respect to CSF flow pulsations. We also investigated the sensitivity of magnetic resonance encephalography to detect flow with a phantom model and sought to replicate earlier pulsation findings in sleep. In this case-control study, we used fast functional MRI to map brain pulsations in groups of healthy sleeping controls (n = 13), healthy awake controls (n = 79), and awake NT1 (n = 21) patients. We measured the very low frequency (0.008 to 0.1) and cardiorespiratory frequencies and calculated in each frequency band the coefficient of variation, spectral power, and full band spectral entropy to obtain brain pulsation maps. We uncovered a brain pulsation profile from healthy waking to sleep to a sleep-related pathology NT1 prominently affected in the vascular-related vasomotor and brain arterial pulsations. Our results established how drivers of brain hydrodynamics are affected by a specific loss of key neurotransmitter governing arousal compared to healthy sleep. We also showed with a phantom model that MREG is sensitive to flow-related signal changes and solidified evidence of brain pulsations in the healthy states of sleep and wakefulness.</AbstractText | [
[
"40111737",
"Narcolepsy: Beyond the Classic Pentad.",
"Narcolepsy is a rare, disabling, chronic neurologic disorder that requires lifelong management of symptoms with pharmacologic and nonpharmacologic methods. The pentad symptoms of narcolepsy include excessive daytime sleepiness, cataplexy, disrupte... | [
[
"40455869",
"Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice.",
"Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a preCGG repeat expansion in the FMR1 gene. Individuals with the FMR1 premutatio... |
40653907 | Integrin β4-Enriched Small Extracellular Vesicle as Drug Delivery Vehicle for Targeting Pulmonary Metastasis of Hepatocellular Carcinoma. | Small extracellular vesicles (sEVs) hold significant promise for targeted drug delivery, owing to their unique ability to target and accumulate in specific tissues. The organotropism of sEVs is primarily determined by the presence of integrins on their surface. In this study, sEV with enriched integrin β4, designated as XP-ITGβ4-sEV, are engineered to enhance lung-targeting capabilities. The therapeutic efficacy of doxorubicin-loaded XP-ITGβ4-sEV (XP-ITGβ4-sEV/Dox) is evaluated in targeting pulmonary metastasis of advanced hepatocellular carcinoma (HCC) using a murine lung metastasis model. Remarkably, treatment with XP-ITGβ4-sEV/Dox effectively suppresses tumor cell colonization in the lungs compared to an equivalent dose of free doxorubicin. Histological analyses reveal a reduction in lung metastatic foci, inhibition of proliferation, and an increase in apoptosis of HCC cells. Notably, XP-ITGβ4-sEV/Dox exhibits a superior therapeutic efficacy with an improved safety profile compared to a higher dose of free doxorubicin that demonstrates similar efficacy. These findings collectively underscore the potential of integrin β4-enriched sEVs as a targeted drug delivery system for addressing pulmonary metastasis of HCC.</AbstractText | [
[
"32772213",
"Splice variants of RAS-translational significance.",
"One of the mechanisms potentially explaining the discrepancy between the number of human genes and the functional complexity of organisms is generating alternative splice variants, an attribute of the vast majority of multi-exon genes.... | [
[
"40796324",
"Exploring the Diagnostic Potential of Core Targets of 6PPD and Its Metabolite 6PPD-Q in Cardiovascular Diseases: An Integrated Analysis Based on Network Toxicology, Molecular Docking, and In Vitro Validation.",
"6PPD (N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine) and its oxidized fo... |
38447117 | Disparities in Genetic Testing for Neurologic Disorders. | Genetic testing is now the standard of care for many neurologic conditions. Health care disparities are unfortunately widespread in the US health care system, but disparities in the utilization of genetic testing for neurologic conditions have not been studied. We tested the hypothesis that access to and results of genetic testing vary according to race, ethnicity, sex, socioeconomic status, and insurance status for adults with neurologic conditions.</AbstractText We analyzed retrospective data from patients who underwent genetic evaluation and testing through our institution's neurogenetics program. We tested for differences between demographic groups in 3 steps of a genetic evaluation pathway: (1) attending a neurogenetic evaluation, (2) completing genetic testing, and (3) receiving a diagnostic result. We compared patients on this genetic evaluation pathway with the population of all neurology outpatients at our institution, using univariate and multivariable logistic regression analyses.</AbstractText Between 2015 and 2022, a total of 128,440 patients were seen in our outpatient neurology clinics and 2,540 patients underwent genetic evaluation. Black patients were less than half as likely as White patients to be evaluated (odds ratio [OR] 0.49, <i We observed unequal utilization of our clinical neurogenetics program for patients from marginalized and minoritized demographic groups, especially Black patients. Among patients who do undergo evaluation, all groups benefit similarly from genetic testing when it is indicated. Understanding and removing barriers to accessing genetic testing will be essential to health care equity and optimal care for all patients with neurologic disorders.</AbstractText | [
[
"36685225",
"A functional network of highly pure enteric neurons in a dish.",
"The enteric nervous system (ENS) is the intrinsic nervous system that innervates the entire digestive tract and regulates major digestive functions. Recent evidence has shown that functions of the ENS critically rely on ent... | [
[
"39556800",
"Middle fossa approach for a petrous apex bony spur causing trigeminal neuralgia: illustrative case.",
"Trigeminal neuralgia (TN) can arise from trigeminal nerve compression at the root entry zone due to neurovascular conflict, which most often presents in the 6th decade of life. The autho... |
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YAML Metadata Warning: empty or missing yaml metadata in repo card (https://huggingface.co/docs/hub/datasets-cards)
Jerjes/neuro-specter2-triplets-multi-pool
This dataset contains anchor papers with their top-K most similar (positive) and most dissimilar (negative) papers based on SPECTER2 embeddings.
Dataset Structure
Each row contains:
anchor_id: Unique identifier for the anchor paperanchor_title: Title of the anchor paperanchor_abstract: Abstract of the anchor paperpositive_pool: List of 5 most similar papers, each as [id, title, abstract]negative_pool: List of 5 most dissimilar papers, each as [id, title, abstract]
Dataset Statistics
- Total anchors: 100,000
- Positives per anchor: 5
- Negatives per anchor: 5
- Embedding model: allenai/specter2_base
Usage
from datasets import load_dataset
dataset = load_dataset("Jerjes/neuro-specter2-triplets-multi-pool")
# Access a sample
sample = dataset["train"][0]
print(f"Anchor: {sample['anchor_title']}")
print(f"Top positive: {sample['positive_pool'][0][1]}") # title of most similar paper
print(f"Top negative: {sample['negative_pool'][0][1]}") # title of most dissimilar paper
Citation
If you use this dataset, please cite the original SPECTER2 paper:
@inproceedings{specter2,
title={SPECTER2: Better Scientific Paper Representations Through Augmented Word Embeddings},
author={Pradeep Dasigi and Kyle Lo and Iz Beltagy and Arman Cohan and Noah A. Smith and Matt Gardner},
booktitle={Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing},
year={2021}
}
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