Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions
Paper • 2402.18060 • Published • 2
question stringclasses 10
values | choicesA stringclasses 10
values | choicesB stringclasses 10
values | choicesC stringclasses 10
values | choicesD stringclasses 10
values | choicesE stringclasses 10
values | answer_idx stringclasses 5
values | answer stringclasses 10
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A 25-year-old man presents to his primary care physician for trouble with focus and concentration. He states that he lives at home with his parents his entire life and recently was able to get a job at a local factory. Ever since the patient started working, he has had trouble focusing on his job. He is unable to stay ... | Bright light therapy and decreased light at night | Ethosuximide | Modafinil | Polysomnography | Zolpidem | A | Bright light therapy and decreased light at night | This patient is presenting with fatigue and an inability to fall asleep until late in the morning suggesting a diagnosis of delayed sleep phase syndrome. The most appropriate initial therapy is light therapy, behavioral therapy, and sleep hygiene practices in addition to decreasing exposure to light at night.
Delayed ... | https://step2.medbullets.com/testview?qid=109002 |
A 68-year-old man presents for evaluation by a neurologist for an involuntary hand tremor that started approximately 3 months ago. The shaking improves when he reaches for objects but returns when he is not using his hand. His temperature is 98.6°F (37.0°C), blood pressure is 115/70 mmHg, pulse is 70/min, and respirati... | Cerebellar stroke | Essential tremor | Huntington disease | Lacunar stroke | Parkinson disease | E | Parkinson disease | This patient who presents with a low amplitude, 4-6 Hz resting tremor that resolves with voluntary movement and associated rigidity most likely has Parkinson disease.
Parkinson disease is caused by degeneration of dopaminergic neurons in the substantia nigra pars compacta of the basal ganglia. This neurodegenerative p... | https://step2.medbullets.com/testview?qid=215182 |
A newborn boy is assessed in the newborn nursery due to central cyanosis that does not respond to oxygen therapy. The patient was born to a G1P1 mother at 39 weeks gestation. The mother had diabetes that was managed with exercise and insulin during the pregnancy. The mother has never been vaccinated and did not follow ... | Tetralogy of Fallot | Total anomalous pulmonary venous return | Transposition of the great vessels | Tricuspid valve atresia | Truncus arteriosus | C | Transposition of the great vessels | This patient is presenting with right axis deviation on ECG and an "egg on a string" heart on chest radiograph suggesting a diagnosis of transposition of the great vessels.
Transposition of the great vessels occurs when the spiral septum that divides the truncus arteriosus into the aorta and pulmonary artery fails to ... | https://bit.ly/3Qq9vcA |
A 55-year-old man presents to the emergency department with nausea and vomiting for the past week. He decided to come in when his symptoms worsened. He feels that his symptoms are exacerbated with large fatty meals and when he drinks alcohol. His wife recently returned from a cruise with symptoms of vomiting and diarrh... | Adhesions | Enteric nervous system damage | Impacted stool | Norovirus | Twisting of the bowel | A | Adhesions | This patient is presenting with abdominal pain and a tympanitic abdomen, which are symptoms suggestive of a small bowel obstruction. In developed countries, these typically occur secondary to adhesions.
Small bowel obstructions (SBO) typically present with an absence of bowel sounds, bowel movements, and flatus, as we... | https://bit.ly/3MoRM2B |
A 52-year-old G3P3 woman presents to clinic with a 2-year history of urinary incontinence. She has had frequent, involuntary loss of urine over the last 2 years but presented today because of 10 days of dysuria. She has been treated for 2 urinary tract infections over the past 6 months. She does not endorse any loss of... | Overflow incontinence | Pelvic organ prolapse | Stress urinary incontinence | Urethral diverticulum | Vesicovaginal fistula | D | Urethral diverticulum | This patient is presenting with a history of dysuria, incontinence, and recurrent lower urinary tract infections in conjunction with a tender anterior vaginal wall mass. The most likely diagnosis is a urethral diverticulum.
A urethral diverticulum is an abnormal, localized outpouching of the urethral mucosa often due ... | https://step2.medbullets.com/testview?qid=216247 |
A 7-year-old boy is brought to the emergency department by his parents for worsening symptoms of previously diagnosed acute sinusitis. Initially, the pediatrician prescribed decongestants and sent the patient home. Since then, the patient has developed a nasal discharge with worsening pain. The patient has a medical hi... | Bleeding and infected vessel of Kiesselbach plexus | Foreign body obstruction | Nasopharyngeal carcinoma | Septal perforation | Sinusitis with bacterial superinfection | B | Foreign body obstruction | This patient presents with unilateral bloody/purulent discharge from the nose suggesting a diagnosis of a nasal foreign body.
The most common cause of unilateral nasal symptoms in a pediatric patient is a nasal foreign body. Nasal foreign bodies tend to be unilateral (though bilateral symptoms are plausible) and prese... | https://bit.ly/3sn97S5 |
A 23-year-old man presents to the emergency department. He was brought in by police for shouting on a subway. The patient claims that little people were trying to kill him and he was acting within his rights to defend himself. The patient has a medical history of marijuana and IV drug use as well as multiple suicide at... | Chlorpromazine | Clozapine | Fluphenazine | Olanzapine | Thioridazine | B | Clozapine | This patient is presenting with symptoms of schizophrenia that are refractory to treatment with both typical and atypical antipsychotics. The most appropriate next step in management is treatment with clozapine.
Schizophrenia presents with auditory and/or visual hallucinations among many other findings. The most appro... | https://step2.medbullets.com/testview?qid=108999 |
A 37-year-old machinist presents to his primary care physician with eye problems. He has felt a mass in his eye that has persisted for the past month. The patient has a medical history of blepharitis treated with eye cleansing and squamous cell carcinoma of the skin treated with Mohs surgery. His temperature is 99.5°F ... | Chalazion | Foreign body | Hordeolum | Ingrown eyelash follicle | Meibomian cell carcinoma | A | Chalazion | This patient presenting with a painless firm and rubbery nodule has symptoms that are suggestive of a chalazion.
Chalazion presents with a hard and painless eyelid nodule. This pathology occurs secondary to granulomatous inflammation of the Meibomian gland. The lesion can be treated with simple excision; however, recu... | https://bit.ly/483O4Um |
A 67-year-old man presents to the emergency department 1 hour after sudden-onset weakness and double vision. His medical history is significant for hyperlipidemia and poorly controlled hypertension. His current medications include atorvastatin and amlodipine. His temperature is 98.6°F (37.0°C), blood pressure is 175/95... | Lateral medulla | Lateral pons | Medial pons | Midbrain | Posterior limb of internal capsule | D | Midbrain | This patient with a history of poorly controlled hypertension, acute onset of left-sided oculomotor nerve palsy (mydriasis, ptosis, and “down and out” pupil), right-sided paresis, and right-sided dysdiadochokinesia most likely has a lacunar stroke of the left midbrain.
Important structures in the midbrain often affect... | https://bit.ly/3FwRzGJ |
A 55-year-old man with a history of polysubstance abuse is found down in his home acutely obtunded. Emergency medical services administered naloxone which immediately woke the patient up and improved his oxygen saturation from 40% to 90%. However, they noted subsequently that the patient demonstrated increased work of ... | Atypical pneumonia | Chronic obstructive pulmonary disease | Community acquired pneumonia | Medication administration | Poor cardiac function | D | Medication administration | This patient is presenting after administration of naloxone with respiratory distress, wheezing, crackles, and pulmonary edema on chest radiography, suggesting acute pulmonary edema. Given the presence of symptoms immediately following naloxone administration, the cause of the pulmonary edema is likely the naloxone (me... | https://step2.medbullets.com/testview?qid=216360 |
This dataset was created based on the format specified in the paper Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions by Hanjie Chen, Zhouxiang Fang, Yash Singla, and Mark Dredze.
If you use this dataset format, please consider citing the original paper as follows:
@misc{chen2024benchmarkinglargelanguagemodels,
title={Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions},
author={Hanjie Chen and Zhouxiang Fang and Yash Singla and Mark Dredze},
year={2024},
eprint={2402.18060},
archivePrefix={arXiv},
primaryClass={cs.CL},
url={https://arxiv.org/abs/2402.18060},
}