Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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kidney development negative regulation of retinoic acid receptor signaling pathway response to retinoic acid response to vitamin A retinoic acid catabolic process retinoic acid metabolic process sterol metabolic process vitamin metabolic process xenobiotic metabolic process | endoplasmic reticulum membrane | all-trans retinoic acid 18-hydroxylase activity all-trans retinoic acid 4-hydrolase activity heme binding iron ion binding monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxygen bi... | Homo sapiens | Alternative splicing Endoplasmic reticulum Heme Iron Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Oxidoreductase Reference proteome | MGLPALLASA | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYP... | kidney development negative regulation of retinoic acid receptor signaling pathway response to retinoic acid response to vitamin A retinoic acid catabolic process retinoic acid metabolic process sterol metabolic process vitamin metabolic process xenobiotic metabolic process endoplasmic reticulum membrane all-trans reti... |
brain development G1 to G0 transition gamma-aminobutyric acid metabolic process glial cell development glutamine metabolic process glycine metabolic process L-serine biosynthetic process neural tube development neuron projection development regulation of gene expression spinal cord development taurine metabolic process... | cytosol; extracellular exosome | electron transfer activity L-malate dehydrogenase activity NAD binding phosphoglycerate dehydrogenase activity | Homo sapiens | 3D-structure Acetylation Amino-acid biosynthesis Direct protein sequencing Disease variant Isopeptide bond NAD Oxidoreductase Phosphoprotein Reference proteome Serine biosynthesis Ubl conjugation | MAFANLRKVL | MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQA... | brain development G1 to G0 transition gamma-aminobutyric acid metabolic process glial cell development glutamine metabolic process glycine metabolic process L-serine biosynthetic process neural tube development neuron projection development regulation of gene expression spinal cord development taurine metabolic process... |
actin filament polymerization activation of phospholipase C activity focal adhesion assembly negative regulation of focal adhesion assembly negative regulation of stress fiber assembly positive regulation of phospholipase activity regulation of small GTPase mediated signal transduction Rho protein signal transduction | actin cytoskeleton; actin filament; cytoplasm; cytosol | GTPase activator activity phospholipase activator activity phospholipase binding SH3 domain binding | Homo sapiens | Alternative splicing Cytoplasm GTPase activation Phosphoprotein Reference proteome SH3-binding | MSAQSLLHSV | MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGATAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHFDYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQSPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCDLSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDLQRDEQKDASDFVASLLPFGN... | actin filament polymerization activation of phospholipase C activity focal adhesion assembly negative regulation of focal adhesion assembly negative regulation of stress fiber assembly positive regulation of phospholipase activity regulation of small GTPase mediated signal transduction Rho protein signal transduction a... |
cell adhesion myoblast fusion positive regulation of angiogenesis proteolysis | extracellular region; nucleoplasm; plasma membrane | metal ion binding metalloendopeptidase activity metallopeptidase activity SH3 domain binding | Homo sapiens | Alternative splicing Cell adhesion Cell membrane Cleavage on pair of basic residues Disulfide bond EGF-like domain Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Phosphoprotein Protease Reference proteome Secreted SH3-binding Signal Transmembrane Transmembrane helix Zinc Zymogen | MAARPLPVSP | MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAP... | cell adhesion myoblast fusion positive regulation of angiogenesis proteolysis extracellular region; nucleoplasm; plasma membrane metal ion binding metalloendopeptidase activity metallopeptidase activity SH3 domain binding Homo sapiens Alternative splicing Cell adhesion Cell membrane Cleavage on pair of basic residues D... |
animal organ morphogenesis cell differentiation nervous system development positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II response to stimulus visual perception | chromatin; nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription activator activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific leucine zipper domain binding nuclear receptor binding RNA polymerase II cis-regulatory re... | Homo sapiens | Activator Cone-rod dystrophy Developmental protein Differentiation Disease variant DNA-binding Homeobox Leber congenital amaurosis Neurogenesis Nucleus Reference proteome Retinitis pigmentosa Sensory transduction Transcription Transcription regulation Vision | MMAYMNPGPH | MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL | animal organ morphogenesis cell differentiation nervous system development positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II response to stimulus visual perception chromatin; nucleus; RNA polymerase II transcription regul... |
canonical NF-kappaB signal transduction cellular response to lipopolysaccharide inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction lipopolysaccharide-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway negative regulation of NF-kappaB transcripti... | cytoplasm; cytosol; endosome membrane; nucleus; plasma membrane | ATP binding molecular adaptor activity protein heterodimerization activity protein homodimerization activity protein kinase activity signaling adaptor activity | Homo sapiens | 3D-structure ATP-binding Nucleotide-binding Phosphoprotein Reference proteome | MACYIYQLPS | MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLL... | canonical NF-kappaB signal transduction cellular response to lipopolysaccharide inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction lipopolysaccharide-mediated signaling pathway MyD88-dependent toll-like receptor signaling pathway negative regulation of NF-kappaB transcripti... |
chromatin organization DNA repair-dependent chromatin remodeling regulation of DNA-templated transcription | centrosome; cytosol; nucleoplasm; nucleus; site of double-strand break | chromatin binding DNA binding histone methyltransferase binding identical protein binding metal ion binding methylated histone binding transcription corepressor binding | Homo sapiens | 3D-structure Alternative splicing Chromatin regulator Chromosomal rearrangement Cytoplasm Cytoskeleton DNA damage Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Zinc Zinc-finger | MAQPPRLSRS | MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGR... | chromatin organization DNA repair-dependent chromatin remodeling regulation of DNA-templated transcription centrosome; cytosol; nucleoplasm; nucleus; site of double-strand break chromatin binding DNA binding histone methyltransferase binding identical protein binding metal ion binding methylated histone binding transcr... |
G protein-coupled receptor signaling pathway | cytosol; plasma membrane | G protein-coupled peptide receptor activity hormone binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MGSPWNGSDG | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRII... | G protein-coupled receptor signaling pathway cytosol; plasma membrane G protein-coupled peptide receptor activity hormone binding Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembran... |
G protein-coupled receptor signaling pathway | plasma membrane | G protein-coupled receptor activity metal ion binding | Homo sapiens | Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Metal-binding Phosphoprotein Receptor Reference proteome Transducer Transmembrane Transmembrane helix Zinc | MASPSLPGSD | MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFR... | G protein-coupled receptor signaling pathway plasma membrane G protein-coupled receptor activity metal ion binding Homo sapiens Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Metal-binding Phosphoprotein Receptor Reference proteome Transducer Transmembrane Transmembrane helix Zinc MASPSLP... |
chiasma assembly mismatch repair | nucleus | ATP binding ATP-dependent DNA damage sensor activity double-stranded DNA binding mismatched DNA binding | Homo sapiens | Alternative splicing ATP-binding Disease variant DNA damage DNA repair DNA-binding Meiosis Nucleotide-binding Premature ovarian failure Reference proteome | MASLGANPRR | MASLGANPRRTPQGPRPGAASSGFPSPAPVPGPREAEEEEVEEEEELAEIHLCVLWNSGYLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDCLLTVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLIL... | chiasma assembly mismatch repair nucleus ATP binding ATP-dependent DNA damage sensor activity double-stranded DNA binding mismatched DNA binding Homo sapiens Alternative splicing ATP-binding Disease variant DNA damage DNA repair DNA-binding Meiosis Nucleotide-binding Premature ovarian failure Reference proteome MASLGAN... |
apoptotic process cytoskeleton-dependent cytokinesis flagellated sperm motility hematopoietic stem cell homeostasis neuron migration positive regulation of apoptotic process positive regulation of intrinsic apoptotic signaling pathway positive regulation of protein ubiquitination regulation of apoptotic process regulat... | axon; cell division site; cytosol; dendrite; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; perikaryon; septin complex; septin ring; sperm annulus; synaptic vesicle | GTP binding GTPase activity identical protein binding magnesium ion binding molecular adaptor activity structural molecule activity | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Cell projection Cilium Coiled coil Cytoplasm Cytoplasmic vesicle Differentiation Direct protein sequencing Flagellum GTP-binding Mitochondrion Nucleotide-binding Nucleus Phosphoprotein Reference proteome Spermatogenesis Synapse Ubl conjugation | MDRSLGWQGN | MDRSLGWQGNSVPEDRTEAGIKRFLEDTTDDGELSKFVKDFSGNASCHPPEAKTWASRPQVPEPRPQAPDLYDDDLEFRPPSRPQSSDNQQYFCAPAPLSPSARPRSPWGKLDPYDSSEDDKEYVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGAEERIMQTVEITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNRKNIQDNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDHKKRKIREEIEHFGIKIYQF... | apoptotic process cytoskeleton-dependent cytokinesis flagellated sperm motility hematopoietic stem cell homeostasis neuron migration positive regulation of apoptotic process positive regulation of intrinsic apoptotic signaling pathway positive regulation of protein ubiquitination regulation of apoptotic process regulat... |
cellular response to nerve growth factor stimulus centrosome localization microtubule cytoskeleton organization microtubule-based movement | centrosome; cytoplasmic dynein complex; cytosol; dynein complex; kinetochore; late endosome; membrane; microtubule | ATP binding dynein heavy chain binding identical protein binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cytoplasm Cytoskeleton Dynein Methylation Microtubule Motor protein Nucleotide-binding Phosphoprotein Reference proteome Transport | MAPVGVEKKL | MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKI... | cellular response to nerve growth factor stimulus centrosome localization microtubule cytoskeleton organization microtubule-based movement centrosome; cytoplasmic dynein complex; cytosol; dynein complex; kinetochore; late endosome; membrane; microtubule ATP binding dynein heavy chain binding identical protein binding H... |
cell cycle proteolysis | extracellular region; secretory granule | serine-type endopeptidase activity serine-type peptidase activity | Homo sapiens | 3D-structure Cell cycle Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Tumor suppressor | MRAPHLHLSA | MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN | cell cycle proteolysis extracellular region; secretory granule serine-type endopeptidase activity serine-type peptidase activity Homo sapiens 3D-structure Cell cycle Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Tumor suppressor MRAPHLHLSA MRAPHLHLSAASGARALAKLLPLLMAQL... |
proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process ubiquitin-dependent protein catabolic process | cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, lid subcomplex; secretory granule lumen | enzyme regulator activity | Homo sapiens | 3D-structure Alternative splicing Isopeptide bond Phosphoprotein Proteasome Reference proteome Ubl conjugation | MKQEGSARRR | MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAAEHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGFFTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKRYKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATLRHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQLEYSEARRTMTNALRKAPQHT... | proteasome-mediated ubiquitin-dependent protein catabolic process regulation of protein catabolic process ubiquitin-dependent protein catabolic process cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; pr... |
anatomical structure development anterior/posterior pattern specification embryonic digit morphogenesis embryonic skeletal joint morphogenesis endoderm development metanephros development organ induction positive regulation of transcription by RNA polymerase II proximal/distal pattern formation regulation of transcript... | chromatin; cytosol; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Isopeptide bond Nucleus Reference proteome Transcription Transcription regulation Ubl conjugation | MFNSVNLGNF | MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL | anatomical structure development anterior/posterior pattern specification embryonic digit morphogenesis embryonic skeletal joint morphogenesis endoderm development metanephros development organ induction positive regulation of transcription by RNA polymerase II proximal/distal pattern formation regulation of transcript... |
intracellular estrogen receptor signaling pathway mRNA processing negative regulation of DNA-templated transcription nervous system development regulation of alternative mRNA splicing, via spliceosome regulation of cell population proliferation RNA metabolic process RNA splicing | cytoplasm; nucleoplasm; nucleus | DNA-binding transcription factor binding mRNA binding RNA binding transcription corepressor activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome RNA-binding | MQNEPLTPGY | MQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGAD... | intracellular estrogen receptor signaling pathway mRNA processing negative regulation of DNA-templated transcription nervous system development regulation of alternative mRNA splicing, via spliceosome regulation of cell population proliferation RNA metabolic process RNA splicing cytoplasm; nucleoplasm; nucleus DNA-bind... |
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process phosphorylation skeletal system development sulfate assimilation | cytosol | adenylylsulfate kinase activity ATP binding nucleotidyltransferase activity protein homodimerization activity sulfate adenylyltransferase (ATP) activity | Homo sapiens | 3D-structure Acetylation ATP-binding Kinase Multifunctional enzyme Nucleotide-binding Nucleotidyltransferase Reference proteome Transferase | MEIPGSLCKK | MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERL... | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process phosphorylation skeletal system development sulfate assimilation cytosol adenylylsulfate kinase activity ATP binding nucleotidyltransferase activity protein homodimerization activity sulfate adenylyltransferase (ATP) activity Homo sapiens 3D-structure Acetylati... |
amyloid fibril formation apoptotic process canonical Wnt signaling pathway cell cycle negative regulation of apoptotic process negative regulation of canonical Wnt signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of extrinsic apoptotic signa... | cytoplasm; cytosol; early endosome; intracellular membrane-bounded organelle; neuronal cell body; nucleoplasm | transcription corepressor activity ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding | Homo sapiens | 3D-structure Apoptosis Biological rhythms Cell cycle Cytoplasm Metal-binding Nucleus Phosphoprotein Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger | MSRPSSTGPS | MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTIS... | amyloid fibril formation apoptotic process canonical Wnt signaling pathway cell cycle negative regulation of apoptotic process negative regulation of canonical Wnt signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of extrinsic apoptotic signa... |
calcium ion homeostasis chromatin remodeling heart process intestinal stem cell homeostasis muscle cell differentiation positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of lymphoid progenitor cell differentiation p... | nucleoplasm; nucleosome; nucleus; Swr1 complex | histone binding metal ion binding nucleosome binding | Homo sapiens | Chromatin regulator Coiled coil Metal-binding Nucleus Phosphoprotein Reference proteome Zinc Zinc-finger | MVEKKTSVRS | MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV | calcium ion homeostasis chromatin remodeling heart process intestinal stem cell homeostasis muscle cell differentiation positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of lymphoid progenitor cell differentiation p... |
cell division endoplasmic reticulum to Golgi vesicle-mediated transport establishment of mitotic spindle orientation Golgi organization meiotic cell cycle mitotic metaphase chromosome alignment mitotic sister chromatid segregation mitotic spindle assembly checkpoint signaling protein localization to kinetochore protein... | cytosol; Dsl1/NZR complex; endoplasmic reticulum; endoplasmic reticulum membrane; kinetochore; kinetochore microtubule; lipid droplet; membrane; nucleus; RZZ complex; spindle pole | centromeric DNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Centromere Chromosome Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Endoplasmic reticulum ER-Golgi transport Kinetochore Lipid droplet Membrane Mitosis Phosphoprotein Protein transport Reference proteome Transport | MASFVTEVLA | MASFVTEVLAHSGRLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPSMQSAQGLITQVDKLSEDIDLLKSRIESEVRRDLHVSTGEFTDLKQQLERDSVVLSLLKQLQEFSTAIEEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLKILKSLSMELTIQKQNILYHLGEEWQKLIVWKFPPSKDTSSLESYLQTELHLYTEQSHKEEKTPMPPISSVLLAFSVLGELHSKLKSFGQMLLKYILRPLASCPSLHAVIESQPNIVIIRFESIMTNLEYPSPSEVFTKIRLVLEVLQKQLLDLPLDTDLENEK... | cell division endoplasmic reticulum to Golgi vesicle-mediated transport establishment of mitotic spindle orientation Golgi organization meiotic cell cycle mitotic metaphase chromosome alignment mitotic sister chromatid segregation mitotic spindle assembly checkpoint signaling protein localization to kinetochore protein... |
4-hydroxyproline catabolic process intrinsic apoptotic signaling pathway in response to oxidative stress proline catabolic process proline catabolic process to glutamate proline metabolic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | intracellular membrane-bounded organelle; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; nucleoplasm | FAD binding proline dehydrogenase activity | Homo sapiens | Acetylation Alternative splicing Disease variant FAD Flavoprotein Mitochondrion Oxidoreductase Proline metabolism Reference proteome Schizophrenia Transit peptide | MALRRALPAL | MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQEAYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSL... | 4-hydroxyproline catabolic process intrinsic apoptotic signaling pathway in response to oxidative stress proline catabolic process proline catabolic process to glutamate proline metabolic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intracellular membrane-bounded organelle... |
branching involved in labyrinthine layer morphogenesis cellular response to BMP stimulus epidermis development epithelium development extracellular matrix organization negative regulation of neural precursor cell proliferation neural tube closure placenta blood vessel development positive regulation of glial cell diffe... | cytoplasm; extracellular exosome; extracellular region; extracellular space; membrane; plasma membrane | serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Disulfide bond Glycoprotein Membrane Protease inhibitor Reference proteome Repeat Secreted Serine protease inhibitor Signal | MAPARTMARA | MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQ... | branching involved in labyrinthine layer morphogenesis cellular response to BMP stimulus epidermis development epithelium development extracellular matrix organization negative regulation of neural precursor cell proliferation neural tube closure placenta blood vessel development positive regulation of glial cell diffe... |
animal organ morphogenesis trehalose catabolic process trehalose metabolic process | extracellular exosome; membrane; plasma membrane; side of membrane | alpha,alpha-trehalase activity | Homo sapiens | Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Glycosidase GPI-anchor Hydrolase Lipoprotein Membrane Reference proteome Signal | MPGRTWELCL | MPGRTWELCLLLLLGLGLGSQEALPPPCESEIYCHGELLNQVQMAKLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPREQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLSHPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNGGRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRYYVPYGGPRPESYSKDVELADTLPEGDREALWAELKAGAESGW... | animal organ morphogenesis trehalose catabolic process trehalose metabolic process extracellular exosome; membrane; plasma membrane; side of membrane alpha,alpha-trehalase activity Homo sapiens Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Glycosidase GPI-anchor Hydrolase Lipo... |
cell adhesion cell migration intracellular signal transduction transmembrane receptor protein tyrosine kinase signaling pathway | cytoplasm; focal adhesion | protein domain specific binding SH3 domain binding | Homo sapiens | Alternative splicing Cell adhesion Phosphoprotein Reference proteome SH3 domain SH3-binding | MAIATSTQLA | MAIATSTQLARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPAGPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVPPPARPCPTSGPPAGPCPPSPDLIYKIPRASGTQLAAPRDALEVYDVPPTALRVPSSGPYDCPASFSHPLTRVAPQPPGEDDAPYDVPLTPKPPAELEPDLEWEGGREPGPPIYAAPSNLKRASALLNLYEAPEELLADGEGGGTDEGIYDVPLLGPEAPPSPEPPGALASHDQDTLAQLLARSPPPPHRPRLPSAESLSRRPLPALPVPEAPSPSP... | cell adhesion cell migration intracellular signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cytoplasm; focal adhesion protein domain specific binding SH3 domain binding Homo sapiens Alternative splicing Cell adhesion Phosphoprotein Reference proteome SH3 domain SH3-binding MAIATSTQLA... |
JNK cascade peptidyl-serine phosphorylation positive regulation of axon extension positive regulation of branching morphogenesis of a nerve positive regulation of JUN kinase activity positive regulation of neuron maturation positive regulation of neuron projection arborization positive regulation of NF-kappaB transcrip... | cytoplasm; membrane | ATP binding enzyme binding identical protein binding IkappaB kinase complex binding JUN kinase kinase kinase activity MAP kinase kinase kinase activity metal ion binding protein homodimerization activity protein kinase binding protein serine kinase activity protein serine/threonine kinase activator activity protein ser... | Homo sapiens | Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Transferase | MANFQEHLSC | MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWM... | JNK cascade peptidyl-serine phosphorylation positive regulation of axon extension positive regulation of branching morphogenesis of a nerve positive regulation of JUN kinase activity positive regulation of neuron maturation positive regulation of neuron projection arborization positive regulation of NF-kappaB transcrip... |
carbohydrate metabolic process central nervous system myelination central nervous system neuron axonogenesis ganglioside biosynthetic process via lactosylceramide glycoprotein biosynthetic process glycosylation neuron maturation O-glycan processing poly-N-acetyllactosamine biosynthetic process positive regulation of em... | Golgi apparatus; Golgi cisterna membrane; Golgi membrane | galactosyltransferase activity metal ion binding N-acetyllactosamine synthase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Homo sapiens | Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Lipid biosynthesis Lipid metabolism Manganese Membrane Metal-binding Reference proteome Signal-anchor Sphingolipid metabolism Transferase Transmembrane Transmembrane helix | MRARRGLLRL | MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGD... | carbohydrate metabolic process central nervous system myelination central nervous system neuron axonogenesis ganglioside biosynthetic process via lactosylceramide glycoprotein biosynthetic process glycosylation neuron maturation O-glycan processing poly-N-acetyllactosamine biosynthetic process positive regulation of em... |
maturation of 5S rRNA mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome positive regulation of cytotoxic T cell differentiation spliceosomal snRNP assembly | Cajal body; catalytic step 2 spliceosome; cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex | RNA binding | Homo sapiens | 3D-structure Allergen Alternative splicing Coiled coil Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Spliceosome Ubl conjugation | MGSSKKHRGE | MGSSKKHRGEKEAAGTTAAAGTGGATEQPPRHREHKKHKHRSGGSGGSGGERRKRSRERGGERGSGRRGAEAEARSSTHGRERSQAEPSERRVKREKRDDGYEAAASSKTSSGDASSLSIEETNKLRAKLGLKPLEVNAIKKEAGTKEEPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAEKRAKLLEEMDQEFGVSTLVEEEFGQRRQDLYSARDLQGLTVEHAIDSFREGETMILTLKDKGVLQEEEDVLVNVNLVDKERAEKNVELRKKKPDYLPYAEDE... | maturation of 5S rRNA mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome positive regulation of cytotoxic T cell differentiation spliceosomal snRNP assembly Cajal body; catalytic step 2 spliceosome; cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus; U2-type precatalytic spliceosome... |
basement membrane organization cellular response to BMP stimulus epithelial cell morphogenesis involved in placental branching establishment or maintenance of cell polarity negative regulation of cell motility negative regulation of cell-cell adhesion negative regulation of neural precursor cell proliferation neural tu... | cytoplasm; extracellular region; membrane; plasma membrane | endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cytoplasm Direct protein sequencing Disease variant Disulfide bond Glycoprotein Membrane Protease inhibitor Reference proteome Repeat Serine protease inhibitor Signal Transmembrane Transmembrane helix | MAQLCGLRRS | MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL | basement membrane organization cellular response to BMP stimulus epithelial cell morphogenesis involved in placental branching establishment or maintenance of cell polarity negative regulation of cell motility negative regulation of cell-cell adhesion negative regulation of neural precursor cell proliferation neural tu... |
attachment of GPI anchor to protein protein retention in ER lumen protein-containing complex assembly | centrosome; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; GPI-anchor transamidase complex; membrane; mitochondrion | tubulin binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disease variant Endoplasmic reticulum Glycoprotein GPI-anchor biosynthesis Membrane Reference proteome Transmembrane Transmembrane helix | MGLLSDPVRR | MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMVEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLR... | attachment of GPI anchor to protein protein retention in ER lumen protein-containing complex assembly centrosome; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; GPI-anchor transamidase complex; membrane; mitochondrion tubulin binding Homo sapiens 3D-structure Alternative splicing Direct protein sequenc... |
apoptotic process apoptotic signaling pathway cellular response to type II interferon chromatin organization intracellular signal transduction negative regulation of translation positive regulation of apoptotic process positive regulation of canonical Wnt signaling pathway positive regulation of cell migration protein ... | cytoplasm; cytosol; nucleoplasm; nucleus; PML body | ATP binding cAMP response element binding protein binding identical protein binding leucine zipper domain binding protein homodimerization activity protein serine kinase activity protein serine/threonine kinase activity small GTPase binding | Homo sapiens | 3D-structure Activator Alternative splicing Apoptosis ATP-binding Chromatin regulator Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transcription Transcription regulation Transferase Translation regulation Tumor suppressor | MSTFRQEDVE | MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYA... | apoptotic process apoptotic signaling pathway cellular response to type II interferon chromatin organization intracellular signal transduction negative regulation of translation positive regulation of apoptotic process positive regulation of canonical Wnt signaling pathway positive regulation of cell migration protein ... |
cell adhesion cell fate commitment epithelial cell differentiation fat cell differentiation morphogenesis of embryonic epithelium negative regulation of cell population proliferation negative regulation of fat cell differentiation positive regulation of DNA-templated transcription positive regulation of epithelial to m... | cytoskeleton; cytosol; focal adhesion; intracellular membrane-bounded organelle; nuclear matrix | I-SMAD binding metal ion binding nuclear androgen receptor binding Roundabout binding transcription coactivator activity | Homo sapiens | Acetylation Activator Alternative splicing Cell junction Cytoplasm Cytoskeleton Differentiation LIM domain Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Wnt signaling pathway Zinc | MEDLDALLSD | MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF... | cell adhesion cell fate commitment epithelial cell differentiation fat cell differentiation morphogenesis of embryonic epithelium negative regulation of cell population proliferation negative regulation of fat cell differentiation positive regulation of DNA-templated transcription positive regulation of epithelial to m... |
regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MAAAVLTDRA | MAAAVLTDRAQVSVTFDDVAVTFTKEEWGQLDLAQRTLYQEVMLENCGLLVSLGCPVPKAELICHLEHGQEPWTRKEDLSQDTCPGDKGKPKTTEPTTCEPALSEGISLQGQVTQGNSVDSQLGQAEDQDGLSEMQEGHFRPGIDPQEKSPGKMSPECDGLGTADGVCSRIGQEQVSPGDRVRSHNSCESGKDPMIQEEENNFKCSECGKVFNKKHLLAGHEKIHSGVKPYECTECGKTFIKSTHLLQHHMIHTGERPYECMECGKAFNRKSYLTQHQRIHSGEKPYKCNECGKAFTHRSNFVLHNRRHTGEKSFVCTEC... | regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat T... |
regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase III general transcription initiation factor binding sequence-specific double-stranded DNA binding | Homo sapiens | 3D-structure Acetylation DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MEPGTNSFRV | MEPGTNSFRVEFPDFSSTILQKLNQQRQQGQLCDVSIVVQGHIFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSSYTGRLVMPAPEIVSYLTAASFLQMWHVVDKCTEVLEGNPTVLCQKLNHGSDHQSPSSSSYNGLVESFELGSGGHTDFPKAQELRDGENEEESTKDELSSQLTEHEYLPSNSSTEHDRLSTEMASQDGEEGASDSAEFHYTRPMYSKPSIMAHKRWIHVKPERLEQACEGMDVHATYDEHQVTESINTVQTEHTVQPSGVEEDFHIGEKKVEAEFDEQADESNYDEQVDFYGS... | regulation of transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase III general transcription initiation factor binding sequence-specific double-st... |
long-term synaptic potentiation negative regulation of receptor internalization positive regulation of synapse assembly regulation of postsynaptic density assembly synapse organization | excitatory synapse; extracellular space; GABA-ergic synapse; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; postsynaptic specialization membrane; Schaffer collateral - CA1 synapse | neurexin family protein binding | Homo sapiens | 3D-structure Cell membrane Glycoprotein Leucine-rich repeat Membrane Postsynaptic cell membrane Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix | MGLHFKWPLG | MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARIC... | long-term synaptic potentiation negative regulation of receptor internalization positive regulation of synapse assembly regulation of postsynaptic density assembly synapse organization excitatory synapse; extracellular space; GABA-ergic synapse; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; postsynapti... |
regulation of postsynaptic specialization assembly regulation of small GTPase mediated signal transduction | cytosol; GABA-ergic synapse; postsynaptic density; postsynaptic specialization | guanyl-nucleotide exchange factor activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Epilepsy Guanine-nucleotide releasing factor Phosphoprotein Reference proteome SH3 domain Synapse | MTLLITGDSI | MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELI... | regulation of postsynaptic specialization assembly regulation of small GTPase mediated signal transduction cytosol; GABA-ergic synapse; postsynaptic density; postsynaptic specialization guanyl-nucleotide exchange factor activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Disease variant Epilepsy Guanine-n... |
regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MASTWAIQAH | MASTWAIQAHMDQDEPLEVKIEEEKYTTRQDWDLRKNNTHSREVFRQYFRQFCYQETSGPREALSRLRELCHQWLRPETHTKEQILELLVLEQFLTILPEELQAWVQEQHPESGEEVVTVLEDLERELDEPGEQVSVHTGEQEMFLQETVRLRKEGEPSMSLQSMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEVSEEMEPHGKTSSKFENDMSKSARCGETREPEEITEEPSACSREDKQPTCDENGVSLTENSDHTEHQRICPGEESYGCDDCGKAFSQHSHLIEHQRIHTGDRPYKCEECGKAFRGRTVLIRH... | regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteome Re... |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translational initiation | cytosol; perinuclear region of cytoplasm | RNA binding translation activator activity | Homo sapiens | Acetylation Alternative splicing Cytoplasm Nonsense-mediated mRNA decay Phosphoprotein Reference proteome Translation regulation | MENSSAASAS | MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDNSLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPE... | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of translational initiation cytosol; perinuclear region of cytoplasm RNA binding translation activator activity Homo sapiens Acetylation Alternative splicing Cytoplasm Nonsense-mediated mRNA decay Phosphoprotein Reference proteome Translatio... |
actin cytoskeleton organization adherens junction maintenance cell adhesion cellular response to fluid shear stress epithelial cell proliferation involved in renal tubule morphogenesis glomerulus morphogenesis microspike assembly negative regulation of epithelial cell proliferation nephron tubule epithelial cell differ... | actin cytoskeleton; cytoplasm; endocytic vesicle; ruffle | actin binding actin monomer binding identical protein binding phospholipid binding signaling receptor binding | Homo sapiens | 3D-structure Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoskeleton Phosphoprotein Reference proteome Tumor suppressor | MEAVIEKECS | MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSH... | actin cytoskeleton organization adherens junction maintenance cell adhesion cellular response to fluid shear stress epithelial cell proliferation involved in renal tubule morphogenesis glomerulus morphogenesis microspike assembly negative regulation of epithelial cell proliferation nephron tubule epithelial cell differ... |
DNA damage response motile cilium assembly positive regulation of DNA-templated transcription positive regulation of gene expression positive regulation of non-motile cilium assembly positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | nuclear body; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific dynein complex binding metal ion binding transcription cis-regulatory region binding | Homo sapiens | Activator Alternative splicing DNA damage Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MAASEAAAAA | MAASEAAAAAGSAALAAGARAVPAATTGAAAAASGPWVPPGPRLRGSRPRPAGATQQPAVPAPPAGELIQPSVSELSRAVRTNILCTVRGCGKILPNSPALNMHLVKSHRLQDGIVNPTIRKDLKTGPKFYCCPIEGCPRGPERPFSQFSLVKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPT... | DNA damage response motile cilium assembly positive regulation of DNA-templated transcription positive regulation of gene expression positive regulation of non-motile cilium assembly positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II nuclear body; nucleus DNA-bind... |
amine transport canalicular bile acid transport cellular response to cAMP glycerol transmembrane transport purine nucleobase transport pyrimidine nucleobase transport response to pain urea transmembrane transport water transport | basolateral plasma membrane; intracellular membrane-bounded organelle; plasma membrane | glycerol channel activity purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity urea channel activity urea transmembrane transporter activity water channel activity | Homo sapiens | Cell membrane Membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport | MQPEGAEKGK | MQPEGAEKGKSFKQRLVLKSSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLLIIVIASSLGLNSGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVGAVIGGLIYVLVIEIHHPEPDSVFKTEQSEDKPEKYELSVIM | amine transport canalicular bile acid transport cellular response to cAMP glycerol transmembrane transport purine nucleobase transport pyrimidine nucleobase transport response to pain urea transmembrane transport water transport basolateral plasma membrane; intracellular membrane-bounded organelle; plasma membrane glyc... |
anatomical structure development animal organ morphogenesis cell differentiation regulation of transcription by RNA polymerase II | chromatin; nucleoplasm | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Alternative splicing Developmental protein Diabetes mellitus Differentiation Disease variant DNA-binding Homeobox Nucleus Paired box Reference proteome Repressor Transcription Transcription regulation | MHQDGISSMN | MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWDCGSFLLPVIAPSCVD... | anatomical structure development animal organ morphogenesis cell differentiation regulation of transcription by RNA polymerase II chromatin; nucleoplasm DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specif... |
animal organ morphogenesis cell differentiation cell-cell signaling fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of gene expression positive regulation of protei... | cytoplasm; extracellular region; extracellular space | fibroblast growth factor receptor binding growth factor activity | Homo sapiens | Disease variant Glycoprotein Growth factor Phosphoprotein Reference proteome Secreted | MAEVGGVFAS | MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR | animal organ morphogenesis cell differentiation cell-cell signaling fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of gene expression positive regulation of protei... |
cell fate specification cell-cell signaling Leydig cell differentiation male sex determination myelination osteoblast differentiation positive regulation of smoothened signaling pathway protein autoprocessing regulation of gene expression regulation of steroid biosynthetic process response to estradiol response to estr... | endoplasmic reticulum membrane; extracellular space; Golgi membrane; plasma membrane | calcium ion binding cholesterol-protein transferase activity patched binding peptidase activity zinc ion binding | Homo sapiens | 3D-structure Autocatalytic cleavage Calcium Cell membrane Developmental protein Disease variant Endoplasmic reticulum Golgi apparatus Hydrolase Lipoprotein Membrane Metal-binding Palmitate Protease Reference proteome Secreted Signal Transferase Zinc | MALLTNLLPL | MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREE... | cell fate specification cell-cell signaling Leydig cell differentiation male sex determination myelination osteoblast differentiation positive regulation of smoothened signaling pathway protein autoprocessing regulation of gene expression regulation of steroid biosynthetic process response to estradiol response to estr... |
anterior/posterior pattern specification brain segmentation cell fate determination cellular response to retinoic acid dorsal/ventral pattern formation embryonic viscerocranium morphogenesis middle ear morphogenesis motor neuron axon guidance muscle structure development negative regulation of neuron differentiation ne... | chromatin; intracellular membrane-bounded organelle; nucleoplasm | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein Disease variant DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MNYEFEREIG | MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLNPGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAAATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFEQALSVSGALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLSTMGQNCGAGLNNDSPEALEVP... | anterior/posterior pattern specification brain segmentation cell fate determination cellular response to retinoic acid dorsal/ventral pattern formation embryonic viscerocranium morphogenesis middle ear morphogenesis motor neuron axon guidance muscle structure development negative regulation of neuron differentiation ne... |
angiogenesis animal organ formation anterior/posterior pattern specification blood vessel remodeling cartilage development embryonic skeletal system morphogenesis gene expression glossopharyngeal nerve morphogenesis parathyroid gland development positive regulation of stem cell proliferation regulation of transcription... | chromatin; nucleoplasm; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific HMG box domain binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MQKATYYDSS | MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCA... | angiogenesis animal organ formation anterior/posterior pattern specification blood vessel remodeling cartilage development embryonic skeletal system morphogenesis gene expression glossopharyngeal nerve morphogenesis parathyroid gland development positive regulation of stem cell proliferation regulation of transcription... |
cellular response to calcium ion intracellular signal transduction negative regulation of GTPase activity negative regulation of Ras protein signal transduction | cytosol; plasma membrane | GTPase activator activity metal ion binding phospholipid binding | Homo sapiens | Alternative splicing Calcium Cell membrane Cytoplasm GTPase activation Membrane Metal-binding Reference proteome Repeat Zinc Zinc-finger | MAKRSSLYIR | MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA... | cellular response to calcium ion intracellular signal transduction negative regulation of GTPase activity negative regulation of Ras protein signal transduction cytosol; plasma membrane GTPase activator activity metal ion binding phospholipid binding Homo sapiens Alternative splicing Calcium Cell membrane Cytoplasm GTP... |
mRNA processing mRNA splicing, via spliceosome | catalytic step 2 spliceosome; endoplasmic reticulum; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex | mRNA binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Endoplasmic reticulum Intellectual disability Isopeptide bond Microsome mRNA processing mRNA splicing Nucleus Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Ubl conjugation | MANQVNGNAV | MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNV... | mRNA processing mRNA splicing, via spliceosome catalytic step 2 spliceosome; endoplasmic reticulum; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex mRNA binding RNA binding Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Endoplasmic re... |
mRNA processing mRNA splicing, via spliceosome RNA splicing RNA splicing, via transesterification reactions spliceosomal tri-snRNP complex assembly | Cajal body; cytosol; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex | identical protein binding RNA binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disease variant Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Retinitis pigmentosa Spliceosome Ubl conjugation | MALSKRELDE | MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPS... | mRNA processing mRNA splicing, via spliceosome RNA splicing RNA splicing, via transesterification reactions spliceosomal tri-snRNP complex assembly Cajal body; cytosol; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex identical protein binding RNA... |
carbohydrate metabolic process regulation of cell population proliferation | cytoplasm; perinuclear region of cytoplasm | protein homodimerization activity RNA binding | Homo sapiens | Acetylation Alternative splicing Coiled coil Phosphoprotein Reference proteome | MDSAGQDINL | MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAARTPAVEGLTEAEEEELRAELTKVEEEIVTLRQVLAAKERHCGELKRRLGLSTLGELKQNLSRSWHDVQVSSAYVKTSEKLGEWNEKVTQSDLYKKTQETLSQAGQKTSAALSTVGSAISRKLGDMRNSATFKSFEDRVGTIKSKVVGDRENGSDNLPSSAGSGDKPLSDPAPF | carbohydrate metabolic process regulation of cell population proliferation cytoplasm; perinuclear region of cytoplasm protein homodimerization activity RNA binding Homo sapiens Acetylation Alternative splicing Coiled coil Phosphoprotein Reference proteome MDSAGQDINL MDSAGQDINLNSPNKGLLSDSMTDVPVDTGVAARTPAVEGLTEAEEEELRAEL... |
regulation of cell shape sensory perception of sound | collagen-containing extracellular matrix; extracellular region | collagen binding | Homo sapiens | 3D-structure Alternative splicing Deafness Disease variant Disulfide bond Extracellular matrix Glycoprotein Hearing Non-syndromic deafness Reference proteome Repeat Secreted Signal | MSAAWIPALG | MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDK... | regulation of cell shape sensory perception of sound collagen-containing extracellular matrix; extracellular region collagen binding Homo sapiens 3D-structure Alternative splicing Deafness Disease variant Disulfide bond Extracellular matrix Glycoprotein Hearing Non-syndromic deafness Reference proteome Repeat Secreted ... |
cerebellar granule cell differentiation excitatory postsynaptic potential excitatory synapse assembly glutamate receptor signaling pathway heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules modulation of chemical synaptic transmission positive regulation of long-term synaptic depression positiv... | dendritic spine; glutamatergic synapse; ionotropic glutamate receptor complex; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density membrane; synapse | glutamate receptor activity identical protein binding PDZ domain binding scaffold protein binding transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Neurodegeneration Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MEVFPFLLVL | MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNM... | cerebellar granule cell differentiation excitatory postsynaptic potential excitatory synapse assembly glutamate receptor signaling pathway heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules modulation of chemical synaptic transmission positive regulation of long-term synaptic depression positiv... |
fibroblast growth factor receptor signaling pathway platelet aggregation | endomembrane system; membrane; mitochondrion; nuclear speck; nucleus | fibroblast growth factor binding | Homo sapiens | Acetylation Alternative splicing Disease variant Membrane Nucleus Reference proteome | MTSELDIFVG | MTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALRVRSGILEQTGATAAVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVGEAPTDPDSQMDDMDMDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLSRGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWP... | fibroblast growth factor receptor signaling pathway platelet aggregation endomembrane system; membrane; mitochondrion; nuclear speck; nucleus fibroblast growth factor binding Homo sapiens Acetylation Alternative splicing Disease variant Membrane Nucleus Reference proteome MTSELDIFVG MTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALR... |
DNA-templated transcription intestinal epithelial cell differentiation negative regulation of DNA-templated transcription negative regulation of neuron projection development negative regulation of Notch signaling pathway negative regulation of transcription by RNA polymerase II positive regulation of neuron projection... | nucleoplasm; nucleus | metal ion binding transcription corepressor activity | Homo sapiens | Alternative splicing Coiled coil Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MAKESGISLK | MAKESGISLKEIQVLARQWKVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDR... | DNA-templated transcription intestinal epithelial cell differentiation negative regulation of DNA-templated transcription negative regulation of neuron projection development negative regulation of Notch signaling pathway negative regulation of transcription by RNA polymerase II positive regulation of neuron projection... |
mRNA splicing, via spliceosome positive regulation of viral genome replication protein folding protein peptidyl-prolyl isomerization protein-containing complex assembly | cytoplasm; cytosol; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; spliceosomal complex; U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex | cyclosporin A binding peptidyl-prolyl cis-trans isomerase activity ribonucleoprotein complex binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Direct protein sequencing Isomerase mRNA processing mRNA splicing Nucleus Reference proteome Rotamase Spliceosome | MAVANSSPVN | MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM | mRNA splicing, via spliceosome positive regulation of viral genome replication protein folding protein peptidyl-prolyl isomerization protein-containing complex assembly cytoplasm; cytosol; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; spliceosomal complex; U4/U6 snRNP; U4/U6 x U5 tri-snRNP compl... |
potassium ion transport regulation of potassium ion transmembrane transport | cytoplasm; plasma membrane; voltage-gated potassium channel complex | aldo-keto reductase (NADP) activity potassium channel regulator activity transmembrane transporter binding voltage-gated potassium channel activity | Homo sapiens | Cytoplasm Ion channel Ion transport NADP Oxidoreductase Potassium Potassium transport Reference proteome Transport Voltage-gated channel | MQVSIACTEQ | MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPAGGGHGNPPGGGGSGPKARAALVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRVPDTCRASIKGYQWLKDKVQS... | potassium ion transport regulation of potassium ion transmembrane transport cytoplasm; plasma membrane; voltage-gated potassium channel complex aldo-keto reductase (NADP) activity potassium channel regulator activity transmembrane transporter binding voltage-gated potassium channel activity Homo sapiens Cytoplasm Ion c... |
ATF6-mediated unfolded protein response bone maturation cholesterol metabolic process endoplasmic reticulum unfolded protein response membrane protein intracellular domain proteolysis mitotic G2 DNA damage checkpoint signaling positive regulation of transcription by RNA polymerase II protein maturation regulation of ch... | cytoplasm; Golgi membrane; membrane | metal ion binding metalloendopeptidase activity transcription regulator activator activity | Homo sapiens | Cholesterol metabolism Cytoplasm Disease variant Glycoprotein Golgi apparatus Hydrolase Ichthyosis Lipid metabolism Membrane Metal-binding Metalloprotease Osteogenesis imperfecta Palmoplantar keratoderma Protease Reference proteome Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix Zinc | MIPVSLVVVV | MIPVSLVVVVVGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSSYSSSSSSSSSSSSSSSSSSSSSSSLHNEQVLQVVVPGINLPVNQLTYFFTAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSF... | ATF6-mediated unfolded protein response bone maturation cholesterol metabolic process endoplasmic reticulum unfolded protein response membrane protein intracellular domain proteolysis mitotic G2 DNA damage checkpoint signaling positive regulation of transcription by RNA polymerase II protein maturation regulation of ch... |
cell cycle cell differentiation cellular response to glucose starvation cellular response to hypoxia chromatin organization circadian rhythm DNA damage response energy homeostasis epigenetic programming in the zygotic pronuclei methylation negative regulation of cell cycle negative regulation of DNA-templated transcrip... | chromatin silencing complex; chromosome, centromeric region; condensed nuclear chromosome; cytoplasmic vesicle; eNoSc complex; heterochromatin; nuclear lamina; nucleolus; nucleoplasm; nucleus; plasma membrane; rDNA heterochromatin | chromatin binding histone H3 methyltransferase activity histone H3K9 methyltransferase activity histone H3K9 trimethyltransferase activity histone methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity transcription cis-regulatory region binding zinc ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Biological rhythms Cell cycle Cell membrane Centromere Chromatin regulator Chromosome Cytoplasmic vesicle Differentiation Host-virus interaction Membrane Metal-binding Methyltransferase Nucleus Phosphoprotein Reference proteome Repressor rRNA processing S-adenosyl-L-methion... | MAENLKGCSV | MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISH... | cell cycle cell differentiation cellular response to glucose starvation cellular response to hypoxia chromatin organization circadian rhythm DNA damage response energy homeostasis epigenetic programming in the zygotic pronuclei methylation negative regulation of cell cycle negative regulation of DNA-templated transcrip... |
cell communication cell division CENP-A containing chromatin assembly chromosome segregation | Cajal body; chromatin; chromocenter; chromosome, centromeric region; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus | identical protein binding metal ion binding | Homo sapiens | 3D-structure Cell cycle Cell division Centromere Chromosome Metal-binding Mitosis Nucleus Phosphoprotein Reference proteome Zinc | MAAQPLRHRS | MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN | cell communication cell division CENP-A containing chromatin assembly chromosome segregation Cajal body; chromatin; chromocenter; chromosome, centromeric region; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus identical protein binding metal ion binding Homo sapiens 3D-structure Cell cycle... |
carbohydrate metabolic process cellular aldehyde metabolic process daunorubicin metabolic process doxorubicin metabolic process lipid metabolic process | cytoplasm; cytosol; extracellular exosome; Golgi apparatus; mitochondrion | alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity electron transfer activity phenanthrene-9,10-epoxide hydrolase activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Golgi apparatus Lipid metabolism Mitochondrion NADP Oxidoreductase Phosphoprotein Reference proteome Transit peptide | MLSAASRVVS | MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSL... | carbohydrate metabolic process cellular aldehyde metabolic process daunorubicin metabolic process doxorubicin metabolic process lipid metabolic process cytoplasm; cytosol; extracellular exosome; Golgi apparatus; mitochondrion alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity electron transfer ... |
camera-type eye photoreceptor cell differentiation glomerular parietal epithelial cell differentiation photoreceptor cell maintenance podocyte differentiation positive regulation of nephron tubule epithelial cell differentiation retina layer formation retina morphogenesis in camera-type eye | apical plasma membrane; cell surface; cilium; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; extracellular space; microvillus; microvillus membrane; photoreceptor outer segment; photoreceptor outer segment membrane; plasma membrane; prominosome; vesicle | actinin binding cadherin binding cholesterol binding | Homo sapiens | Acetylation Alternative splicing Cell membrane Cell projection Cilium Cone-rod dystrophy Direct protein sequencing Disease variant Endoplasmic reticulum Glycoprotein Membrane Phosphoprotein Reference proteome Retinitis pigmentosa Signal Stargardt disease Transmembrane Transmembrane helix | MALVLGSLLL | MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIR... | camera-type eye photoreceptor cell differentiation glomerular parietal epithelial cell differentiation photoreceptor cell maintenance podocyte differentiation positive regulation of nephron tubule epithelial cell differentiation retina layer formation retina morphogenesis in camera-type eye apical plasma membrane; cell... |
actomyosin structure organization cell cycle cell division cortical actin cytoskeleton organization positive regulation of protein localization to cell cortex | cell cortex; cell junction; cytoskeleton; cytosol; extracellular exosome; focal adhesion; nucleoplasm; plasma membrane; spectrin | actin binding PH domain binding spectrin binding structural molecule activity | Homo sapiens | Acetylation Actin-binding Alternative splicing Cell cycle Cell division Cell membrane Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Membrane Mitosis Phosphoprotein Reference proteome Transport Ubl conjugation | MTTEVGSVSE | MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQD... | actomyosin structure organization cell cycle cell division cortical actin cytoskeleton organization positive regulation of protein localization to cell cortex cell cortex; cell junction; cytoskeleton; cytosol; extracellular exosome; focal adhesion; nucleoplasm; plasma membrane; spectrin actin binding PH domain binding ... |
DNA recombination DNA repair double-strand break repair via homologous recombination female meiosis sister chromatid cohesion male meiosis I meiotic DNA recombinase assembly positive regulation of G2/M transition of mitotic cell cycle reciprocal meiotic recombination sister chromatid cohesion spermatogenesis telomere m... | cell junction; cytoplasm; cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; Rad51B-Rad51C-Rad51D-XRCC2 complex; Rad51C-XRCC3 complex; replication fork | ATP binding ATP-dependent DNA damage sensor activity crossover junction DNA endonuclease activity DNA binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cytoplasm Disease variant DNA damage DNA recombination DNA repair DNA-binding Fanconi anemia Mitochondrion Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MRGKTFRFEM | MRGKTFRFEMQRDLVSFPLSPAVRVKLVSAGFQTAEELLEVKPSELSKEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRK... | DNA recombination DNA repair double-strand break repair via homologous recombination female meiosis sister chromatid cohesion male meiosis I meiotic DNA recombinase assembly positive regulation of G2/M transition of mitotic cell cycle reciprocal meiotic recombination sister chromatid cohesion spermatogenesis telomere m... |
axon guidance keratan sulfate biosynthetic process protein O-linked mannosylation | extracellular exosome; Golgi apparatus; Golgi membrane | glucuronosyltransferase activity metal ion binding N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity | Homo sapiens | Congenital muscular dystrophy Disease variant Dystroglycanopathy Glycoprotein Glycosyltransferase Golgi apparatus Lissencephaly Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MQMSYAIRCA | MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVKAQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPLSVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLRSCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGLREMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTNYSRWVNLPEESLLRPAYVVP... | axon guidance keratan sulfate biosynthetic process protein O-linked mannosylation extracellular exosome; Golgi apparatus; Golgi membrane glucuronosyltransferase activity metal ion binding N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Homo sapiens Congenital muscular dystrophy Disease variant D... |
male gonad development proteolysis single fertilization | external side of plasma membrane; plasma membrane; sperm head plasma membrane | metal ion binding metalloendopeptidase activity metallopeptidase activity | Homo sapiens | Disulfide bond EGF-like domain Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protease Reference proteome Signal Transmembrane Transmembrane helix Zinc Zymogen | MAVGEPLVHI | MAVGEPLVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYVKGICQNP... | male gonad development proteolysis single fertilization external side of plasma membrane; plasma membrane; sperm head plasma membrane metal ion binding metalloendopeptidase activity metallopeptidase activity Homo sapiens Disulfide bond EGF-like domain Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protea... |
angiogenesis apoptotic process cell differentiation endothelial cell migration extrinsic apoptotic signaling pathway immune response positive regulation of angiogenesis positive regulation of endothelial cell proliferation positive regulation of extrinsic apoptotic signaling pathway positive regulation of protein catab... | extracellular region; extracellular space; perinuclear region of cytoplasm; plasma membrane | cytokine activity receptor ligand activity signaling receptor binding tumor necrosis factor receptor binding | Homo sapiens | 3D-structure Alternative splicing Angiogenesis Apoptosis Cell membrane Cleavage on pair of basic residues Cytokine Developmental protein Differentiation Disulfide bond Glycoprotein Membrane Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix | MAARRSQRRR | MAARRSQRRRGRRGEPGTALLVPLALGLGLALACLGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH | angiogenesis apoptotic process cell differentiation endothelial cell migration extrinsic apoptotic signaling pathway immune response positive regulation of angiogenesis positive regulation of endothelial cell proliferation positive regulation of extrinsic apoptotic signaling pathway positive regulation of protein catab... |
inorganic anion transport iodide transport monoatomic ion transport regulation of pH regulation of protein localization sensory perception of sound sulfate transport | apical plasma membrane; brush border membrane; extracellular exosome; membrane; plasma membrane | bicarbonate transmembrane transporter activity chloride transmembrane transporter activity chloride:bicarbonate antiporter activity iodide transmembrane transporter activity oxalate transmembrane transporter activity secondary active sulfate transmembrane transporter activity sulfate transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Chloride Deafness Disease variant Membrane Non-syndromic deafness Reference proteome Transmembrane Transmembrane helix Transport | MAAPGGRSEP | MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLE... | inorganic anion transport iodide transport monoatomic ion transport regulation of pH regulation of protein localization sensory perception of sound sulfate transport apical plasma membrane; brush border membrane; extracellular exosome; membrane; plasma membrane bicarbonate transmembrane transporter activity chloride tr... |
positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II protein ubiquitination regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly somatic stem cell population maintenance transcription initia... | core mediator complex; mediator complex; nuclear body; nucleoplasm; nucleus; transcription regulator complex; ubiquitin ligase complex | transcription coactivator activity ubiquitin protein ligase activity | Homo sapiens | 3D-structure Activator Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MGEPQQVSAL | MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP | positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II protein ubiquitination regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly somatic stem cell population maintenance transcription initia... |
actin filament-based movement actin polymerization or depolymerization protein-containing complex assembly response to other organism | actin cytoskeleton; actin filament; cytoplasmic vesicle; cytosol; ruffle | actin binding profilin binding protein folding chaperone SH3 domain binding | Homo sapiens | 3D-structure Actin-binding Alternative splicing Cell projection Cytoplasm Cytoplasmic vesicle Cytoskeleton Methylation Phosphoprotein Reference proteome Repeat | MPVPPPPAPP | MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPP... | actin filament-based movement actin polymerization or depolymerization protein-containing complex assembly response to other organism actin cytoskeleton; actin filament; cytoplasmic vesicle; cytosol; ruffle actin binding profilin binding protein folding chaperone SH3 domain binding Homo sapiens 3D-structure Actin-bindi... |
action potential initiation apoptosome assembly cellular response to calcium ion cellular response to xenobiotic stimulus chemical synaptic transmission endocytosis excitatory chemical synaptic transmission exocytosis gene expression inhibitory chemical synaptic transmission membrane hyperpolarization mitochondrial dep... | axon initial segment; cell surface; mitochondrion; node of Ranvier; plasma membrane; synapse; voltage-gated potassium channel complex | calmodulin binding voltage-gated potassium channel activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disease variant Epilepsy Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation Voltage-gated channel | MGLKARRAAG | MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEFETYADALWWGLITLATIGYG... | action potential initiation apoptosome assembly cellular response to calcium ion cellular response to xenobiotic stimulus chemical synaptic transmission endocytosis excitatory chemical synaptic transmission exocytosis gene expression inhibitory chemical synaptic transmission membrane hyperpolarization mitochondrial dep... |
chemical synaptic transmission nervous system development potassium ion transmembrane transport | axon initial segment; node of Ranvier; plasma membrane; synapse; voltage-gated potassium channel complex | ankyrin binding calmodulin binding voltage-gated potassium channel activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disease variant Epilepsy Intellectual disability Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Ubl conjugation Voltage-gated channel | MVQKSRNGGV | MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKV... | chemical synaptic transmission nervous system development potassium ion transmembrane transport axon initial segment; node of Ranvier; plasma membrane; synapse; voltage-gated potassium channel complex ankyrin binding calmodulin binding voltage-gated potassium channel activity Homo sapiens 3D-structure Alternative splic... |
androgen metabolic process carbohydrate biosynthetic process cell adhesion estrogen metabolic process learning long-term memory proteoglycan biosynthetic process | Golgi apparatus; Golgi membrane; membrane | HNK-1 sulfotransferase activity sulfotransferase activity | Homo sapiens | Carbohydrate metabolism Glycoprotein Golgi apparatus Lipid metabolism Membrane Reference proteome Signal-anchor Steroid metabolism Transferase Transmembrane Transmembrane helix | MHHQWLLLAA | MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIPEELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKV... | androgen metabolic process carbohydrate biosynthetic process cell adhesion estrogen metabolic process learning long-term memory proteoglycan biosynthetic process Golgi apparatus; Golgi membrane; membrane HNK-1 sulfotransferase activity sulfotransferase activity Homo sapiens Carbohydrate metabolism Glycoprotein Golgi ap... |
DNA damage response DNA recombination DNA repair double-strand break repair via homologous recombination double-strand break repair via synthesis-dependent strand annealing interstrand cross-link repair positive regulation of mitotic cell cycle spindle assembly checkpoint regulation of centrosome duplication resolution... | chromosome, telomeric region; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; Rad51C-XRCC3 complex; replication fork | ATP binding ATP-dependent DNA damage sensor activity DNA binding | Homo sapiens | Acetylation ATP-binding Cytoplasm Disease variant DNA damage DNA recombination DNA repair DNA-binding Mitochondrion Nucleotide-binding Nucleus Reference proteome | MDLDLLDLNP | MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSA... | DNA damage response DNA recombination DNA repair double-strand break repair via homologous recombination double-strand break repair via synthesis-dependent strand annealing interstrand cross-link repair positive regulation of mitotic cell cycle spindle assembly checkpoint regulation of centrosome duplication resolution... |
centrosome cycle DNA repair DNA strand invasion double-strand break repair via homologous recombination in utero embryonic development meiotic cell cycle mitotic cell cycle multicellular organism growth negative regulation of neuron apoptotic process neurogenesis positive regulation of neurogenesis regulation of fibrob... | centrosome; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; Rad51B-Rad51C-Rad51D-XRCC2 complex; replication fork | ATP binding ATP-dependent DNA damage sensor activity DNA binding | Homo sapiens | 3D-structure Cytoplasm Cytoskeleton Disease variant DNA damage DNA recombination DNA repair DNA-binding Fanconi anemia Nucleus Phosphoprotein Premature ovarian failure Reference proteome | MCSAFHRAES | MCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDILEFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQSSEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRVNGGESVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCDVDIDYRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLVSRCLKSNSLKKHFFIIGESGVEFC | centrosome cycle DNA repair DNA strand invasion double-strand break repair via homologous recombination in utero embryonic development meiotic cell cycle mitotic cell cycle multicellular organism growth negative regulation of neuron apoptotic process neurogenesis positive regulation of neurogenesis regulation of fibrob... |
epidermis development protein modification process | cytoplasm; plasma membrane | metal ion binding protein-glutamine gamma-glutamyltransferase activity | Homo sapiens | Acetylation Acyltransferase Alternative splicing Calcium Cytoplasm Direct protein sequencing Disease variant Metal-binding Reference proteome Transferase | MAQGLEVALT | MAQGLEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETGPLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSFQGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDN... | epidermis development protein modification process cytoplasm; plasma membrane metal ion binding protein-glutamine gamma-glutamyltransferase activity Homo sapiens Acetylation Acyltransferase Alternative splicing Calcium Cytoplasm Direct protein sequencing Disease variant Metal-binding Reference proteome Transferase MAQG... |
apoptotic process cellular response to mechanical stimulus immune response positive regulation of myoblast differentiation positive regulation of myoblast fusion positive regulation of non-canonical NF-kappaB signal transduction positive regulation of T cell chemotaxis signal transduction T cell activation T cell chemo... | cytoplasm; extracellular space; plasma membrane | cysteine-type endopeptidase inhibitor activity involved in apoptotic process cytokine activity identical protein binding signaling receptor binding tumor necrosis factor receptor binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cytokine Cytoplasm Disulfide bond Glycoprotein Membrane Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix | MEESVVRPSV | MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGLAFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV | apoptotic process cellular response to mechanical stimulus immune response positive regulation of myoblast differentiation positive regulation of myoblast fusion positive regulation of non-canonical NF-kappaB signal transduction positive regulation of T cell chemotaxis signal transduction T cell activation T cell chemo... |
fibroblast growth factor receptor signaling pathway signal transduction | cytoplasm; plasma membrane | fibroblast growth factor receptor binding identical protein binding transmembrane receptor protein tyrosine kinase adaptor activity | Homo sapiens | 3D-structure Lipoprotein Membrane Myristate Phosphoprotein Reference proteome | MGSCCSCLNR | MGSCCSCLNRDSVPDNHPTKFKVTNVDDEGVELGSGVMELTQSELVLHLHRREAVRWPYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCSRAEEIFNLLQDLMQCNSINVMEEPVIITRNSHPAELDLPRAPQPPNALGYTVSSFSNGCPGEGPRFSAPRRLSTSSLRHPSLGEESTHALIAPDEQSHTYVNTPASEDDHRRGRHCLQPLPEGQAPFLPQARGPDQRDPQVFLQPGQVKFVLGPTPARRHMVKCQGLCPSLHDPPHHNNNNEAPSECPAQPKCTYENVTGGLWRGAGWRLSPEEPGWNGLAHRRAALL... | fibroblast growth factor receptor signaling pathway signal transduction cytoplasm; plasma membrane fibroblast growth factor receptor binding identical protein binding transmembrane receptor protein tyrosine kinase adaptor activity Homo sapiens 3D-structure Lipoprotein Membrane Myristate Phosphoprotein Reference proteom... |
adaptive immune response calcium-mediated signaling gene expression immune response inflammatory response integrin-mediated signaling pathway intracellular signal transduction lymphocyte homeostasis mast cell degranulation positive regulation of protein kinase activity Ras protein signal transduction regulation of T ce... | cell-cell junction; COP9 signalosome; Golgi apparatus; immunological synapse; membrane; membrane raft; plasma membrane | protein kinase binding signaling receptor complex adaptor activity | Homo sapiens | Adaptive immunity Alternative splicing Cell membrane Direct protein sequencing Immunity Lipoprotein Mast cell degranulation Membrane Palmitate Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation | MEEAILVPCV | MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN | adaptive immune response calcium-mediated signaling gene expression immune response inflammatory response integrin-mediated signaling pathway intracellular signal transduction lymphocyte homeostasis mast cell degranulation positive regulation of protein kinase activity Ras protein signal transduction regulation of T ce... |
cell division chromosome segregation G protein-coupled receptor signaling pathway learning long-term memory long-term synaptic potentiation mitotic cell cycle negative regulation of ERK1 and ERK2 cascade negative regulation of G protein-coupled receptor signaling pathway negative regulation of MAP kinase activity negat... | centrosome; cytoplasm; dendrite; dendritic spine; glutamatergic synapse; microtubule; nuclear body; nucleus; plasma membrane; PML body; postsynaptic density; spindle; spindle pole | G-protein alpha-subunit binding GDP-dissociation inhibitor activity GTPase activating protein binding GTPase activator activity GTPase activity microtubule binding protein kinase binding signaling receptor complex adaptor activity | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Cell membrane Cell projection Cytoplasm Cytoskeleton GTPase activation Membrane Microtubule Nucleus Phosphoprotein Reference proteome Repeat Signal transduction inhibitor Synapse | MPGKPKHLGV | MPGKPKHLGVPNGRMVLAVSDGELSSTTGPQGQGEGRGSSLSIHSLPSGPSSPFPTEEQPVASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDTQQLAQEARNIYQEFLSSQALSPVNIDRQAWLGEEVLAEPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYRECLLAEAEGRPLREPGSSRLGSPDATRKKPKLKPGKSLPLGVEELGQLPPVEGPGGRPLRKSFRRELGGTANAALRRESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSTEGESESRPGKYCCVYLPDGTASLALARP... | cell division chromosome segregation G protein-coupled receptor signaling pathway learning long-term memory long-term synaptic potentiation mitotic cell cycle negative regulation of ERK1 and ERK2 cascade negative regulation of G protein-coupled receptor signaling pathway negative regulation of MAP kinase activity negat... |
organelle localization positive regulation of stress-activated protein kinase signaling cascade protein autoubiquitination ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; intracellular membrane-bounded organelle; late endosome membrane; lysosomal membrane; nuclear inner membrane; nucleoplasm | JUN kinase binding metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | 3D-structure Alternative splicing Disease variant Endoplasmic reticulum Endosome Epilepsy Glycoprotein Lysosome Membrane Metal-binding Nucleus Reference proteome Signal Transferase Transmembrane Transmembrane helix Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MLLSIGMLML | MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSA... | organelle localization positive regulation of stress-activated protein kinase signaling cascade protein autoubiquitination ubiquitin-dependent protein catabolic process cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; intracellular membrane-bounded organelle; late endosome membrane; ... |
chloride ion homeostasis estrous cycle one-carbon metabolic process | apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane | carbonate dehydratase activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Lyase Membrane Metal-binding Reference proteome Signal Transmembrane Transmembrane helix Zinc | MPRRSLHAAA | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVV... | chloride ion homeostasis estrous cycle one-carbon metabolic process apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane carbonate dehydratase activity zinc ion binding Homo sapiens 3D-structure Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Lyase Membrane Metal... |
protein localization signal transduction | cytosol; mitochondrion; plasma membrane; protein-containing complex | protein kinase A binding | Homo sapiens | 3D-structure Cytoplasm Membrane Mitochondrion Phosphoprotein Reference proteome Repeat Transit peptide | MRGAGPSPRQ | MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNHALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKSSLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQSSLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVNTFTKYISPDAAKPIPITEAM... | protein localization signal transduction cytosol; mitochondrion; plasma membrane; protein-containing complex protein kinase A binding Homo sapiens 3D-structure Cytoplasm Membrane Mitochondrion Phosphoprotein Reference proteome Repeat Transit peptide MRGAGPSPRQ MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKN... |
calcium ion regulated lysosome exocytosis calcium ion-regulated exocytosis of neurotransmitter cellular response to calcium ion phagocytosis phagosome-lysosome fusion plasma membrane repair positive regulation of calcium ion-dependent exocytosis regulation of bone remodeling regulation of calcium ion-dependent exocytos... | axon; cytosol; dense core granule; early phagosome; extracellular exosome; hippocampal mossy fiber to CA3 synapse; lysosomal membrane; lysosome; peroxisomal membrane; peroxisome; phagocytic vesicle membrane; plasma membrane; presynaptic membrane; synapse; synaptic vesicle; synaptic vesicle membrane | calcium ion binding calcium-dependent phospholipid binding calmodulin binding clathrin binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding SNARE binding syntaxin binding | Homo sapiens | 3D-structure Alternative splicing Calcium Calmodulin-binding Cell membrane Cell projection Cytoplasmic vesicle Exocytosis Lipoprotein Lysosome Membrane Metal-binding Palmitate Peroxisome Phosphoprotein Reference proteome Repeat Synapse Transmembrane Transmembrane helix | MYRDPEAASP | MYRDPEAASPGAPSRDVLLVSAIITVSLSVTVVLCGLCHWCQRKLGKRYKNSLETVGTPDSGRGRSEKKAIKLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKK... | calcium ion regulated lysosome exocytosis calcium ion-regulated exocytosis of neurotransmitter cellular response to calcium ion phagocytosis phagosome-lysosome fusion plasma membrane repair positive regulation of calcium ion-dependent exocytosis regulation of bone remodeling regulation of calcium ion-dependent exocytos... |
actin filament polymerization cell adhesion endocytosis inflammatory response innate immune response signal transduction | actin filament; cleavage furrow; cytoplasm; cytosol; lamellipodium; membrane; perinuclear region of cytoplasm; plasma membrane; uropod | actin filament binding identical protein binding | Homo sapiens | 3D-structure Alternative splicing Cell adhesion Cell membrane Cell projection Coiled coil Cytoplasm Cytoskeleton Disease variant Endocytosis Immunity Inflammatory response Innate immunity Membrane Phosphoprotein Reference proteome SH3 domain | MMPQLQFKDA | MMPQLQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPK... | actin filament polymerization cell adhesion endocytosis inflammatory response innate immune response signal transduction actin filament; cleavage furrow; cytoplasm; cytosol; lamellipodium; membrane; perinuclear region of cytoplasm; plasma membrane; uropod actin filament binding identical protein binding Homo sapiens 3D... |
intracellular protein transport tRNA export from nucleus tRNA re-export from nucleus | cytoplasm; cytosol; nuclear matrix; nuclear pore; nucleoplasm | small GTPase binding tRNA binding | Homo sapiens | Acetylation Cytoplasm Direct protein sequencing Nucleus Reference proteome RNA-binding Transport tRNA-binding | MDEQALLGLN | MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQRTYSDDHVKFFCFQVLEHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIRNKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEEARRNTLIKDTMREQCIPNLVESWYQILQNYQFTNSEVTCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSIEVLREEACDCLFEVVNKGMDPVDKMKLVESLCQVLQSAGFFSIDQEEDVDFLARFSKLVNGMGQSLIVSWSKLIKNGDIKNAQE... | intracellular protein transport tRNA export from nucleus tRNA re-export from nucleus cytoplasm; cytosol; nuclear matrix; nuclear pore; nucleoplasm small GTPase binding tRNA binding Homo sapiens Acetylation Cytoplasm Direct protein sequencing Nucleus Reference proteome RNA-binding Transport tRNA-binding MDEQALLGLN MDEQA... |
deoxyribonucleoside monophosphate catabolic process epithelial cell differentiation nucleoside salvage positive regulation of cell growth purine nucleotide catabolic process | cytoplasm; cytosol; extracellular exosome; nucleus | deoxyribonucleoside 5'-monophosphate N-glycosidase activity identical protein binding protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Glycosidase Hydrolase Nucleotide metabolism Nucleus Phosphoprotein Reference proteome | MAAAMVPGRS | MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT | deoxyribonucleoside monophosphate catabolic process epithelial cell differentiation nucleoside salvage positive regulation of cell growth purine nucleotide catabolic process cytoplasm; cytosol; extracellular exosome; nucleus deoxyribonucleoside 5'-monophosphate N-glycosidase activity identical protein binding protein h... |
axoneme assembly central nervous system development intracellular signal transduction nervous system development neuron migration retina development in camera-type eye | cytoskeleton; cytosol; microtubule; microtubule associated complex; neuron projection | microtubule binding protein kinase binding | Homo sapiens | 3D-structure Alternative splicing Cell projection Chromosomal rearrangement Cytoplasm Developmental protein Differentiation Disease variant Epilepsy Lissencephaly Microtubule Neurogenesis Phosphoprotein Reference proteome Repeat Ubl conjugation | MELDFGHFDE | MELDFGHFDERDKTSRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSATAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTS... | axoneme assembly central nervous system development intracellular signal transduction nervous system development neuron migration retina development in camera-type eye cytoskeleton; cytosol; microtubule; microtubule associated complex; neuron projection microtubule binding protein kinase binding Homo sapiens 3D-structu... |
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway feeding behavior galanin-activated signaling pathway inositol phosphate metabolic process learning or memory muscle contraction neur... | cilium; membrane; plasma membrane | galanin receptor activity neuropeptide binding peptide hormone binding | Homo sapiens | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MNVSGCPGAG | MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASG... | adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway feeding behavior galanin-activated signaling pathway inositol phosphate metabolic process learning or memory muscle contraction neur... |
chemical synaptic transmission eating behavior excitatory postsynaptic potential negative regulation of DNA replication negative regulation of potassium ion transport negative regulation of transmission of nerve impulse neuropeptide signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathw... | extracellular region; perinuclear region of cytoplasm; postsynapse; rough endoplasmic reticulum; secretory granule; synaptic vesicle | neuropeptide hormone activity type 1 orexin receptor binding type 2 orexin receptor binding | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Disease variant Disulfide bond Endoplasmic reticulum Neuropeptide Pyrrolidone carboxylic acid Reference proteome Signal Synapse | MNLPSTKVSW | MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI | chemical synaptic transmission eating behavior excitatory postsynaptic potential negative regulation of DNA replication negative regulation of potassium ion transport negative regulation of transmission of nerve impulse neuropeptide signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathw... |
cellular response to hormone stimulus chemical synaptic transmission feeding behavior neuropeptide signaling pathway positive regulation of ERK1 and ERK2 cascade regulation of cytosolic calcium ion concentration | plasma membrane; synapse | G protein-coupled receptor activity orexin receptor activity peptide binding peptide hormone binding | Homo sapiens | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MEPSATPGAQ | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVL... | cellular response to hormone stimulus chemical synaptic transmission feeding behavior neuropeptide signaling pathway positive regulation of ERK1 and ERK2 cascade regulation of cytosolic calcium ion concentration plasma membrane; synapse G protein-coupled receptor activity orexin receptor activity peptide binding peptid... |
cellular response to hormone stimulus chemical synaptic transmission circadian sleep/wake cycle process feeding behavior locomotion neuropeptide signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway regulation of circadian sleep/wake cycle, wakefulness regulation of cytosolic calcium... | plasma membrane; synapse | neuropeptide receptor activity orexin receptor activity peptide binding peptide hormone binding | Homo sapiens | 3D-structure Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MSGTKLEDSP | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPI... | cellular response to hormone stimulus chemical synaptic transmission circadian sleep/wake cycle process feeding behavior locomotion neuropeptide signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway regulation of circadian sleep/wake cycle, wakefulness regulation of cytosolic calcium... |
intracellular protein transport protein import into mitochondrial matrix protein targeting to mitochondrion | fibrillar center; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; TIM23 mitochondrial import inner membrane translocase complex | ATP binding protein-folding chaperone binding | Homo sapiens | 3D-structure ATP-binding Membrane Mitochondrion Mitochondrion inner membrane Nucleotide-binding Phosphoprotein Protein transport Reference proteome Transit peptide Translocation Transport | MAAAALRSGW | MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGELPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARRKYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSAESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKFKEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCE... | intracellular protein transport protein import into mitochondrial matrix protein targeting to mitochondrion fibrillar center; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; TIM23 mitochondrial import inner membrane translocase complex ATP binding protein-folding chaperone binding Homo sapiens 3D-str... |
autophagosome maturation autophagy endosome transport via multivesicular body sorting pathway ESCRT III complex disassembly establishment of protein localization exit from mitosis late endosome to lysosome transport late endosome to vacuole transport macroautophagy membrane fission membrane invagination midbody absciss... | amphisome membrane; autophagosome membrane; chromatin; cytosol; ESCRT III complex; extracellular exosome; kinetochore; kinetochore microtubule; lysosomal membrane; membrane; membrane coat; midbody; multivesicular body; multivesicular body membrane; nuclear envelope; nuclear pore; plasma membrane | phosphatidylcholine binding protein domain specific binding | Homo sapiens | 3D-structure Acetylation Coiled coil Direct protein sequencing Endosome Host-virus interaction Membrane Nucleus Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation | MDLLFGRRKT | MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD | autophagosome maturation autophagy endosome transport via multivesicular body sorting pathway ESCRT III complex disassembly establishment of protein localization exit from mitosis late endosome to lysosome transport late endosome to vacuole transport macroautophagy membrane fission membrane invagination midbody absciss... |
actin filament organization cell migration dendritic spine development ephrin receptor signaling pathway epidermal growth factor receptor signaling pathway immunological synapse formation lamellipodium assembly negative regulation of cell population proliferation negative regulation of endoplasmic reticulum stress-indu... | cytoplasm; cytosol; endoplasmic reticulum; postsynaptic density; vesicle membrane | cytoskeletal anchor activity phosphotyrosine residue binding protein-containing complex binding receptor tyrosine kinase binding scaffold protein binding signaling adaptor activity signaling receptor complex adaptor activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Endoplasmic reticulum Phosphoprotein Reference proteome Repeat SH2 domain SH3 domain Translation regulation | MTEEVIVIAK | MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDF... | actin filament organization cell migration dendritic spine development ephrin receptor signaling pathway epidermal growth factor receptor signaling pathway immunological synapse formation lamellipodium assembly negative regulation of cell population proliferation negative regulation of endoplasmic reticulum stress-indu... |
negative regulation of ERK1 and ERK2 cascade regulation of neurotransmitter receptor activity | extracellular exosome; extracellular region; plasma membrane; side of membrane | acetylcholine receptor binding | Homo sapiens | Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Reference proteome Signal | MAGLALQPGT | MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL | negative regulation of ERK1 and ERK2 cascade regulation of neurotransmitter receptor activity extracellular exosome; extracellular region; plasma membrane; side of membrane acetylcholine receptor binding Homo sapiens Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Ref... |
cell division microtubule cytoskeleton organization mitotic spindle elongation mitotic spindle midzone assembly positive regulation of cell population proliferation regulation of cytokinesis | chromosome; contractile ring; cytoplasm; cytosol; intercellular bridge; microtubule cytoskeleton; midbody; mitotic spindle midzone; nucleoplasm; nucleus; plasma membrane; spindle; spindle microtubule; spindle pole | identical protein binding kinesin binding microtubule binding protein kinase binding | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Chromosome Coiled coil Cytoplasm Cytoskeleton Microtubule Nucleus Oncogene Phosphoprotein Reference proteome | MRRSEVLAEE | MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEALDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAP... | cell division microtubule cytoskeleton organization mitotic spindle elongation mitotic spindle midzone assembly positive regulation of cell population proliferation regulation of cytokinesis chromosome; contractile ring; cytoplasm; cytosol; intercellular bridge; microtubule cytoskeleton; midbody; mitotic spindle midzon... |
G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway negative regulation of signal transduction positive regulation of GTPase activity regulation of G protein-coupled receptor signaling pathway | cytosol; nuclear body; nucleoplasm; nucleus; plasma membrane; synapse | G-protein alpha-subunit binding GTPase activator activity GTPase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm GTPase activation Lipoprotein Nucleus Palmitate Phosphoprotein Reference proteome Signal transduction inhibitor | MFNRAVSRLS | MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT | G protein-coupled acetylcholine receptor signaling pathway G protein-coupled receptor signaling pathway negative regulation of signal transduction positive regulation of GTPase activity regulation of G protein-coupled receptor signaling pathway cytosol; nuclear body; nucleoplasm; nucleus; plasma membrane; synapse G-pro... |
attachment of spindle microtubules to kinetochore cell division microtubule bundle formation microtubule polymerization mitotic sister chromatid segregation mitotic spindle assembly mitotic spindle assembly checkpoint signaling protein stabilization regulation of chromosome segregation | cytoplasm; kinetochore; microtubule; nucleolus; nucleoplasm; nucleus; spindle; spindle matrix | DNA binding heparin binding metal ion binding microtubule binding RNA binding | Homo sapiens | Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Cytoplasm Cytoskeleton DNA-binding Kinetochore Metal-binding Microtubule Mitosis Nucleus Reference proteome Repeat Zinc Zinc-finger | MGRKKKKQLK | MGRKKKKQLKPWCWYCNRDFDDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKETIDAVPNAIPGRTDIELEIYGMEGIPEKDMDERRRLLEQKTQESQKKKQQDDSDEYDDDDSAASTSFQPQPVQPQQGYIPPMAQPGLPPVPGAPGMPPGIPPLMPGVPPLMPGMPPVMPGMPPGMMPMGGMMPPGPGIPPLMPGMPPGMPPPVPRPGIPPMTQAQAVSAPGILNRPPAPTATVPAPQPPVTKPLFPSAGQMGTPVTSSSTASSNSESLSASSKALFPSTAQAQAAVQGPVGTDFKPLNSTPATTTEPPKP... | attachment of spindle microtubules to kinetochore cell division microtubule bundle formation microtubule polymerization mitotic sister chromatid segregation mitotic spindle assembly mitotic spindle assembly checkpoint signaling protein stabilization regulation of chromosome segregation cytoplasm; kinetochore; microtubu... |
cellular component biogenesis epithelial structure maintenance hair follicle development negative regulation of transcription by RNA polymerase II nervous system development positive regulation of cellular component biogenesis positive regulation of transcription by RNA polymerase II regulation of cell migration regula... | cell leading edge; nucleolus; nucleoplasm; nucleus; plasma membrane; transcription regulator complex | enzyme binding LIM domain binding transcription coregulator activity | Homo sapiens | Alternative splicing Nucleus Reference proteome Ubl conjugation | MSSTPHDPFY | MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLI... | cellular component biogenesis epithelial structure maintenance hair follicle development negative regulation of transcription by RNA polymerase II nervous system development positive regulation of cellular component biogenesis positive regulation of transcription by RNA polymerase II regulation of cell migration regula... |
branching involved in ureteric bud morphogenesis branchiomeric skeletal muscle development bronchiole development developmental process diaphragm development embryonic digestive tract morphogenesis epithelial cell differentiation gland development glomerulus development kidney development lung alveolus development lung... | chromatin; nucleoplasm; nucleus; transcription regulator complex | bHLH transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific E-box binding histone deacetylase binding nuclear androgen receptor bi... | Homo sapiens | DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MSTGSLSDVE | MSTGSLSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGTTAS | branching involved in ureteric bud morphogenesis branchiomeric skeletal muscle development bronchiole development developmental process diaphragm development embryonic digestive tract morphogenesis epithelial cell differentiation gland development glomerulus development kidney development lung alveolus development lung... |
post-translational protein targeting to endoplasmic reticulum membrane protein insertion into ER membrane tail-anchored membrane protein insertion into ER membrane | cytoplasm; endoplasmic reticulum membrane; extracellular exosome; GET complex; nucleolus; nucleoplasm | arsenite transmembrane transporter activity ATP binding ATP hydrolysis activity membrane insertase activity metal ion binding | Homo sapiens | 3D-structure Acetylation ATP-binding Cardiomyopathy Cytoplasm Disease variant Endoplasmic reticulum Hydrolase Metal-binding Nucleotide-binding Nucleus Reference proteome Transport Zinc | MAAGVAGWGV | MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPL... | post-translational protein targeting to endoplasmic reticulum membrane protein insertion into ER membrane tail-anchored membrane protein insertion into ER membrane cytoplasm; endoplasmic reticulum membrane; extracellular exosome; GET complex; nucleolus; nucleoplasm arsenite transmembrane transporter activity ATP bindin... |
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