Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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methionyl-tRNA aminoacylation | cytosol; membrane | ATP binding methionine-tRNA ligase activity protein homodimerization activity tRNA binding zinc ion binding | Escherichia coli | 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Metal-binding Nucleotide-binding Protein biosynthesis Reference proteome RNA-binding tRNA-binding Zinc | MTQVAKKILV | MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK | methionyl-tRNA aminoacylation cytosol; membrane ATP binding methionine-tRNA ligase activity protein homodimerization activity tRNA binding zinc ion binding Escherichia coli 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Metal-binding Nucleotide-binding Protein biosynthesis Reference proteome RNA-binding tRNA-binding Zinc MTQVAKKILV MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK |
glutaminyl-tRNA aminoacylation glutamyl-tRNA aminoacylation | cytosol | ATP binding glutamine-tRNA ligase activity | Escherichia coli | 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Protein biosynthesis Reference proteome | MSEAEARPTN | MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE | glutaminyl-tRNA aminoacylation glutamyl-tRNA aminoacylation cytosol ATP binding glutamine-tRNA ligase activity Escherichia coli 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Protein biosynthesis Reference proteome MSEAEARPTN MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYQGEGEMVTMPNHPNKPEMGSRQVPFSGEIWIDRADFREEANKQYKRLVLGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPVEIRLYDRLFSVPNPGAADDFLSVINPESLVIKQGFAEPSLKDAVAGKAFQFEREGYFCLDSRHSTAEKPVFNRTVGLRDTWAKVGE |
asparagine biosynthetic process DNA damage response L-asparagine biosynthetic process | cytosol | aspartate-ammonia ligase activity ATP binding identical protein binding protein homodimerization activity | Escherichia coli | 3D-structure Amino-acid biosynthesis Asparagine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Reference proteome | MKTAYIAKQR | MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL | asparagine biosynthetic process DNA damage response L-asparagine biosynthetic process cytosol aspartate-ammonia ligase activity ATP binding identical protein binding protein homodimerization activity Escherichia coli 3D-structure Amino-acid biosynthesis Asparagine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Reference proteome MKTAYIAKQR MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL |
acute-phase response arginine biosynthetic process argininosuccinate metabolic process aspartate metabolic process cellular response to amine stimulus cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to dexamethasone stimulus cellular response to glucagon stimulus cellular response to laminar fluid shear stress cellular response to lipopolysaccharide cellular response to oleic acid cellular response to tumor necrosis factor cellular response to type II interferon circadian rhythm citrulline metabolic process diaphragm development kidney development liver development midgut development negative regulation of leukocyte cell-cell adhesion positive regulation of nitric oxide biosynthetic process response to estradiol response to growth hormone response to mycotoxin response to nutrient response to xenobiotic stimulus response to zinc ion urea cycle | cell body fiber; cytoplasm; cytosol; extracellular exosome; mitochondrial outer membrane; nucleoplasm; perikaryon | amino acid binding argininosuccinate synthase activity ATP binding identical protein binding RNA binding toxic substance binding | Homo sapiens | 3D-structure Acetylation Amino-acid biosynthesis Arginine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Disease variant Ligase Nucleotide-binding Phosphoprotein Reference proteome Urea cycle | MSSKGSVVLA | MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK | acute-phase response arginine biosynthetic process argininosuccinate metabolic process aspartate metabolic process cellular response to amine stimulus cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to dexamethasone stimulus cellular response to glucagon stimulus cellular response to laminar fluid shear stress cellular response to lipopolysaccharide cellular response to oleic acid cellular response to tumor necrosis factor cellular response to type II interferon circadian rhythm citrulline metabolic process diaphragm development kidney development liver development midgut development negative regulation of leukocyte cell-cell adhesion positive regulation of nitric oxide biosynthetic process response to estradiol response to growth hormone response to mycotoxin response to nutrient response to xenobiotic stimulus response to zinc ion urea cycle cell body fiber; cytoplasm; cytosol; extracellular exosome; mitochondrial outer membrane; nucleoplasm; perikaryon amino acid binding argininosuccinate synthase activity ATP binding identical protein binding RNA binding toxic substance binding Homo sapiens 3D-structure Acetylation Amino-acid biosynthesis Arginine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Disease variant Ligase Nucleotide-binding Phosphoprotein Reference proteome Urea cycle MSSKGSVVLA MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK |
antiviral innate immune response cellular response to interferon-alpha cellular response to interferon-beta cellular response to virus defense response to bacterium defense response to virus glucose homeostasis glucose metabolic process interleukin-27-mediated signaling pathway negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of IP-10 production negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication positive regulation of cellular respiration positive regulation of interferon-beta production positive regulation of monocyte chemotactic protein-1 production positive regulation of tumor necrosis factor production protein complex oligomerization regulation of ribonuclease activity response to virus surfactant homeostasis toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway type I interferon-mediated signaling pathway | cytoplasm; cytosol; endoplasmic reticulum; extracellular region; membrane; mitochondrion; nucleoplasm; nucleus; ribosome | 2'-5'-oligoadenylate synthetase activity ATP binding double-stranded RNA binding metal ion binding | Homo sapiens | 3D-structure Alternative splicing Antiviral defense ATP-binding Cytoplasm Disease variant Endoplasmic reticulum Host-virus interaction Immunity Innate immunity Lipoprotein Magnesium Metal-binding Microsome Mitochondrion Nucleotide-binding Nucleotidyltransferase Nucleus Prenylation Reference proteome RNA-binding Secreted Transferase | MMDLRNTPAK | MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL | antiviral innate immune response cellular response to interferon-alpha cellular response to interferon-beta cellular response to virus defense response to bacterium defense response to virus glucose homeostasis glucose metabolic process interleukin-27-mediated signaling pathway negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of IP-10 production negative regulation of type I interferon-mediated signaling pathway negative regulation of viral genome replication positive regulation of cellular respiration positive regulation of interferon-beta production positive regulation of monocyte chemotactic protein-1 production positive regulation of tumor necrosis factor production protein complex oligomerization regulation of ribonuclease activity response to virus surfactant homeostasis toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway type I interferon-mediated signaling pathway cytoplasm; cytosol; endoplasmic reticulum; extracellular region; membrane; mitochondrion; nucleoplasm; nucleus; ribosome 2'-5'-oligoadenylate synthetase activity ATP binding double-stranded RNA binding metal ion binding Homo sapiens 3D-structure Alternative splicing Antiviral defense ATP-binding Cytoplasm Disease variant Endoplasmic reticulum Host-virus interaction Immunity Innate immunity Lipoprotein Magnesium Metal-binding Microsome Mitochondrion Nucleotide-binding Nucleotidyltransferase Nucleus Prenylation Reference proteome RNA-binding Secreted Transferase MMDLRNTPAK MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL |
negative regulation of platelet aggregation negative regulation of serine-type endopeptidase activity negative regulation of thrombin-activated receptor signaling pathway trypsinogen activation | extracellular space; serine protease inhibitor complex | calcium ion binding molecular function inhibitor activity potassium channel inhibitor activity protease binding serine-type endopeptidase inhibitor activity sulfate binding zymogen binding | Bos taurus | 3D-structure Direct protein sequencing Disulfide bond Pharmaceutical Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MKMSRLCLSV | MKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGAIGPWENL | negative regulation of platelet aggregation negative regulation of serine-type endopeptidase activity negative regulation of thrombin-activated receptor signaling pathway trypsinogen activation extracellular space; serine protease inhibitor complex calcium ion binding molecular function inhibitor activity potassium channel inhibitor activity protease binding serine-type endopeptidase inhibitor activity sulfate binding zymogen binding Bos taurus 3D-structure Direct protein sequencing Disulfide bond Pharmaceutical Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal MKMSRLCLSV MKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGAIGPWENL |
cellular response to peptide hormone stimulus negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction positive regulation of cytosolic calcium ion concentration positive regulation of epithelial cell proliferation positive regulation of pancreatic juice secretion positive regulation of peptide hormone secretion regulation of acrosome reaction regulation of store-operated calcium entry response to ethanol response to nutrient levels sperm capacitation | extracellular exosome | endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Direct protein sequencing Disease variant Disulfide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MKVTGIFLLS | MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC | cellular response to peptide hormone stimulus negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction positive regulation of cytosolic calcium ion concentration positive regulation of epithelial cell proliferation positive regulation of pancreatic juice secretion positive regulation of peptide hormone secretion regulation of acrosome reaction regulation of store-operated calcium entry response to ethanol response to nutrient levels sperm capacitation extracellular exosome endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Homo sapiens 3D-structure Direct protein sequencing Disease variant Disulfide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal MKVTGIFLLS MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC |
response to steroid hormone | endoplasmic reticulum; extracellular space; protein-containing complex | carbohydrate binding IgE binding IgG binding serine-type endopeptidase inhibitor activity | Gallus gallus | Allergen Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Reference proteome Repeat Secreted Serine protease inhibitor Signal | MAMAGVFVLF | MAMAGVFVLFSFVLCGFLPDAAFGAEVDCSRFPNATDKEGKDVLVCNKDLRPICGTDGVTYTNDCLLCAYSIEFGTNISKEHDGECKETVPMNCSSYANTTSEDGKVMVLCNRAFNPVCGTDGVTYDNECLLCAHKVEQGASVDKRHDGGCRKELAAVSVDCSEYPKPDCTAEDRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC | response to steroid hormone endoplasmic reticulum; extracellular space; protein-containing complex carbohydrate binding IgE binding IgG binding serine-type endopeptidase inhibitor activity Gallus gallus Allergen Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Reference proteome Repeat Secreted Serine protease inhibitor Signal MAMAGVFVLF MAMAGVFVLFSFVLCGFLPDAAFGAEVDCSRFPNATDKEGKDVLVCNKDLRPICGTDGVTYTNDCLLCAYSIEFGTNISKEHDGECKETVPMNCSSYANTTSEDGKVMVLCNRAFNPVCGTDGVTYDNECLLCAHKVEQGASVDKRHDGGCRKELAAVSVDCSEYPKPDCTAEDRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC |
blood coagulation regulation of blood coagulation | blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane | heparin binding identical protein binding protease binding serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Heparin-binding Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal Thrombophilia | MYSNVIGTVT | MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK | blood coagulation regulation of blood coagulation blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane heparin binding identical protein binding protease binding serine-type endopeptidase inhibitor activity Homo sapiens 3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Heparin-binding Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal Thrombophilia MYSNVIGTVT MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK |
acute-phase response blood coagulation | collagen-containing extracellular matrix; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; intracellular membrane-bounded organelle; platelet alpha granule lumen | identical protein binding protease binding serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Acute phase Alternative splicing Blood coagulation Direct protein sequencing Endoplasmic reticulum Extracellular matrix Glycoprotein Hemostasis Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MPSSVSWGIL | MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK | acute-phase response blood coagulation collagen-containing extracellular matrix; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; intracellular membrane-bounded organelle; platelet alpha granule lumen identical protein binding protease binding serine-type endopeptidase inhibitor activity Homo sapiens 3D-structure Acute phase Alternative splicing Blood coagulation Direct protein sequencing Endoplasmic reticulum Extracellular matrix Glycoprotein Hemostasis Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal MPSSVSWGIL MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK |
acute-phase response inflammatory response maintenance of gastrointestinal epithelium regulation of lipid metabolic process | azurophil granule lumen; blood microparticle; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; nucleus; platelet alpha granule lumen; secretory granule lumen | DNA binding serine-type endopeptidase inhibitor activity | Homo sapiens | 3D-structure Acute phase Alternative splicing Direct protein sequencing Disease variant Glycoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MERMLPLLAL | MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA | acute-phase response inflammatory response maintenance of gastrointestinal epithelium regulation of lipid metabolic process azurophil granule lumen; blood microparticle; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; nucleus; platelet alpha granule lumen; secretory granule lumen DNA binding serine-type endopeptidase inhibitor activity Homo sapiens 3D-structure Acute phase Alternative splicing Direct protein sequencing Disease variant Glycoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal MERMLPLLAL MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA |
embryo development ending in birth or egg hatching intracellular amino acid homeostasis monoatomic ion homeostasis monoatomic ion transport response to corticosterone response to estrogen response to progesterone response to steroid hormone | cytosol; early endosome lumen; endoplasmic reticulum; extracellular region; extracellular space; intracellular membrane-bounded organelle; phagocytic vesicle; phagolysosome; vesicle | calcium ion binding protease binding | Gallus gallus | 3D-structure Acetylation Allergen Calcium Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Phosphoprotein Reference proteome Secreted Signal | MGSIGAASME | MGSIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFLFCIKHIATNAVLFFGRCVSP | embryo development ending in birth or egg hatching intracellular amino acid homeostasis monoatomic ion homeostasis monoatomic ion transport response to corticosterone response to estrogen response to progesterone response to steroid hormone cytosol; early endosome lumen; endoplasmic reticulum; extracellular region; extracellular space; intracellular membrane-bounded organelle; phagocytic vesicle; phagolysosome; vesicle calcium ion binding protease binding Gallus gallus 3D-structure Acetylation Allergen Calcium Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Phosphoprotein Reference proteome Secreted Signal MGSIGAASME MGSIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFLFCIKHIATNAVLFFGRCVSP |
regulation of blood pressure vasodilation | extracellular region | hormone activity metalloendopeptidase inhibitor activity toxin activity | Gloydius blomhoffii | 3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hypotensive agent Metalloenzyme inhibitor Metalloprotease inhibitor Protease inhibitor Pyrrolidone carboxylic acid Repeat Secreted Signal Toxin Vasoactive Vasodilator | MFVSRLAASG | MFVSRLAASGLLLLALMALSLDGKPVQQWSQGRPPGPPIPRLVVQQWSQGLPPGPPIPRLVVQQWSQGLPPGPPIPPLVVQQWSQGLPPRPKIPPLVVQQWSQGLPPRPKIPPLVVQKWDPPPVSPPLLLQPHESPAGGTTALREELSLGPEAASGPAAAGADGGRSGSKAPAALHRLSKSKGASATSASASRPMRDLRTDGKQARQNWARMVNPDHHAVGGCCCGGGGGGARRLKGLVKKGVAKGCFGLKLDRIGTMSGLGC | regulation of blood pressure vasodilation extracellular region hormone activity metalloendopeptidase inhibitor activity toxin activity Gloydius blomhoffii 3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hypotensive agent Metalloenzyme inhibitor Metalloprotease inhibitor Protease inhibitor Pyrrolidone carboxylic acid Repeat Secreted Signal Toxin Vasoactive Vasodilator MFVSRLAASG MFVSRLAASGLLLLALMALSLDGKPVQQWSQGRPPGPPIPRLVVQQWSQGLPPGPPIPRLVVQQWSQGLPPGPPIPPLVVQQWSQGLPPRPKIPPLVVQQWSQGLPPRPKIPPLVVQKWDPPPVSPPLLLQPHESPAGGTTALREELSLGPEAASGPAAAGADGGRSGSKAPAALHRLSKSKGASATSASASRPMRDLRTDGKQARQNWARMVNPDHHAVGGCCCGGGGGGARRLKGLVKKGVAKGCFGLKLDRIGTMSGLGC |
cartilage development cellular response to UV-A connective tissue replacement involved in inflammatory response wound healing negative regulation of apoptotic process negative regulation of catalytic activity negative regulation of endopeptidase activity negative regulation of membrane protein ectodomain proteolysis negative regulation of metallopeptidase activity negative regulation of trophoblast cell migration positive regulation of cell population proliferation regulation of integrin-mediated signaling pathway response to cytokine response to hormone response to peptide hormone | basement membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen | cytokine activity growth factor activity metalloendopeptidase inhibitor activity peptidase inhibitor activity protease binding zinc ion binding | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Growth factor Metal-binding Metalloenzyme inhibitor Metalloprotease inhibitor Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Zinc | MAPFEPLASG | MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA | cartilage development cellular response to UV-A connective tissue replacement involved in inflammatory response wound healing negative regulation of apoptotic process negative regulation of catalytic activity negative regulation of endopeptidase activity negative regulation of membrane protein ectodomain proteolysis negative regulation of metallopeptidase activity negative regulation of trophoblast cell migration positive regulation of cell population proliferation regulation of integrin-mediated signaling pathway response to cytokine response to hormone response to peptide hormone basement membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen cytokine activity growth factor activity metalloendopeptidase inhibitor activity peptidase inhibitor activity protease binding zinc ion binding Homo sapiens 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Growth factor Metal-binding Metalloenzyme inhibitor Metalloprotease inhibitor Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Zinc MAPFEPLASG MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA |
defense response negative regulation of blood vessel remodeling negative regulation of collagen catabolic process negative regulation of elastin catabolic process negative regulation of extracellular matrix disassembly negative regulation of peptidase activity negative regulation of proteolysis regulation of tissue remodeling supramolecular fiber organization | cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; plasma membrane; tertiary granule lumen; vesicle | amyloid-beta binding cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity identical protein binding peptidase inhibitor activity protease binding | Homo sapiens | 3D-structure Age-related macular degeneration Amyloid Amyloidosis Direct protein sequencing Disease variant Disulfide bond Glycoprotein Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor | MAGPLRAPLL | MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA | defense response negative regulation of blood vessel remodeling negative regulation of collagen catabolic process negative regulation of elastin catabolic process negative regulation of extracellular matrix disassembly negative regulation of peptidase activity negative regulation of proteolysis regulation of tissue remodeling supramolecular fiber organization cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; plasma membrane; tertiary granule lumen; vesicle amyloid-beta binding cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity identical protein binding peptidase inhibitor activity protease binding Homo sapiens 3D-structure Age-related macular degeneration Amyloid Amyloidosis Direct protein sequencing Disease variant Disulfide bond Glycoprotein Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor MAGPLRAPLL MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of proteolysis | cytoplasm; extracellular exosome; extracellular space; vesicle | cysteine-type endopeptidase inhibitor activity | Homo sapiens | Direct protein sequencing Disulfide bond Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor | MARPLCTLLL | MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA | detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of proteolysis cytoplasm; extracellular exosome; extracellular space; vesicle cysteine-type endopeptidase inhibitor activity Homo sapiens Direct protein sequencing Disulfide bond Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor MARPLCTLLL MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA |
detection of chemical stimulus involved in sensory perception of bitter taste | cytoplasm; extracellular space; vesicle | cysteine-type endopeptidase inhibitor activity | Homo sapiens | Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor | MAQYLSTLLL | MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES | detection of chemical stimulus involved in sensory perception of bitter taste cytoplasm; extracellular space; vesicle cysteine-type endopeptidase inhibitor activity Homo sapiens Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor MAQYLSTLLL MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES |
cell-cell adhesion keratinocyte differentiation negative regulation of peptidase activity negative regulation of proteolysis peptide cross-linking | cornified envelope; cytoplasm; cytosol; extracellular space; nucleoplasm; peptidase inhibitor complex | cysteine-type endopeptidase inhibitor activity protease binding | Homo sapiens | 3D-structure Acetylation Cell adhesion Cytoplasm Direct protein sequencing Ichthyosis Protease inhibitor Reference proteome Thiol protease inhibitor | MIPGGLSEAK | MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF | cell-cell adhesion keratinocyte differentiation negative regulation of peptidase activity negative regulation of proteolysis peptide cross-linking cornified envelope; cytoplasm; cytosol; extracellular space; nucleoplasm; peptidase inhibitor complex cysteine-type endopeptidase inhibitor activity protease binding Homo sapiens 3D-structure Acetylation Cell adhesion Cytoplasm Direct protein sequencing Ichthyosis Protease inhibitor Reference proteome Thiol protease inhibitor MIPGGLSEAK MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF |
blood coagulation inflammatory response negative regulation of blood coagulation negative regulation of cell adhesion negative regulation of proteolysis positive regulation of apoptotic process positive regulation of cytosolic calcium ion concentration vasodilation | blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane; platelet alpha granule lumen | cysteine-type endopeptidase inhibitor activity heparin binding hormone activity signaling receptor binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Phosphoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator | MKLITILFLC | MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS | blood coagulation inflammatory response negative regulation of blood coagulation negative regulation of cell adhesion negative regulation of proteolysis positive regulation of apoptotic process positive regulation of cytosolic calcium ion concentration vasodilation blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane; platelet alpha granule lumen cysteine-type endopeptidase inhibitor activity heparin binding hormone activity signaling receptor binding zinc ion binding Homo sapiens 3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Phosphoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator MKLITILFLC MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSSRIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHDWGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQHGLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKNKGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTPIPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDDWIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEINPTTQMKESYYFDLTDGLS |
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation | extracellular region | cysteine-type endopeptidase inhibitor activity | Bos taurus | Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Inflammatory response Phosphoprotein Protease inhibitor Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator | MKLITILFLC | MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKIDTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL | blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Bos taurus Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Inflammatory response Phosphoprotein Protease inhibitor Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator MKLITILFLC MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKIDTVKKATVQVVAGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHGSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL |
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation | extracellular region | cysteine-type endopeptidase inhibitor activity | Bos taurus | Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator | MKLITILFLC | MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDTVKKATVQVVGGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHRSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL | blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Bos taurus Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator MKLITILFLC MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDTVKKATVQVVGGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHRSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL |
acute-phase response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation | extracellular region | cysteine-type endopeptidase inhibitor activity | Rattus norvegicus | Acute phase Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator | MKLITILLLC | MKLITILLLCSRLLPSLAQEEGAQELNCNDETVFQAVDTALKKYNAELESGNQFVLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALREVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPSLREDCVPLPYGDHGECTGHTHVDIHNTIAGFSQSCDLYPGDDLFELLPKNCRGCPREIPVDSPELKEALGHSIAQLNAQHNHIFYFKIDTVKKATSQVVAGVIYVIEFIARETNCSKQSKTELTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVRVQETKEGTTRLLNSCEYKGRLSKARAGPAPDHQAEASTVTP | acute-phase response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Rattus norvegicus Acute phase Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator MKLITILLLC MKLITILLLCSRLLPSLAQEEGAQELNCNDETVFQAVDTALKKYNAELESGNQFVLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALREVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPSLREDCVPLPYGDHGECTGHTHVDIHNTIAGFSQSCDLYPGDDLFELLPKNCRGCPREIPVDSPELKEALGHSIAQLNAQHNHIFYFKIDTVKKATSQVVAGVIYVIEFIARETNCSKQSKTELTADCETKHLGQSLNCNANVYMRPWENKVVPTVRCQALDMMISRPPGFSPFRLVRVQETKEGTTRLLNSCEYKGRLSKARAGPAPDHQAEASTVTP |
negative regulation of serine-type peptidase activity | extracellular space | serine-type endopeptidase inhibitor activity | Hirudo medicinalis | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Pharmaceutical Protease inhibitor Secreted Serine protease inhibitor Sulfation | VVYTDCTESG | VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ | negative regulation of serine-type peptidase activity extracellular space serine-type endopeptidase inhibitor activity Hirudo medicinalis 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Pharmaceutical Protease inhibitor Secreted Serine protease inhibitor Sulfation VVYTDCTESG VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ |
negative regulation of endopeptidase activity protein catabolic process in the vacuole | cytoplasm; nucleus; protein-containing complex; vacuole | aspartic-type endopeptidase inhibitor activity endopeptidase inhibitor activity protease binding | Saccharomyces cerevisiae | 3D-structure Acetylation Aspartic protease inhibitor Direct protein sequencing Protease inhibitor Reference proteome | MNTDQQKVSE | MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE | negative regulation of endopeptidase activity protein catabolic process in the vacuole cytoplasm; nucleus; protein-containing complex; vacuole aspartic-type endopeptidase inhibitor activity endopeptidase inhibitor activity protease binding Saccharomyces cerevisiae 3D-structure Acetylation Aspartic protease inhibitor Direct protein sequencing Protease inhibitor Reference proteome MNTDQQKVSE MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE |
erythrocyte differentiation heme biosynthetic process negative regulation of endothelial cell proliferation negative regulation of hydrolase activity protein homotetramerization | cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion; protein-containing complex | angiostatin binding ATPase binding ATPase inhibitor activity calmodulin binding identical protein binding protein homodimerization activity structural molecule activity | Bos taurus | 3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide | MAATALAART | MAATALAARTRQAVWSVWAMQGRGFGSESGDNVRSSAGAVRDAGGAFGKREQAEEERYFRARAKEQLAALKKHHENEISHHAKEIERLQKEIERHKQSIKKLKQSEDDD | erythrocyte differentiation heme biosynthetic process negative regulation of endothelial cell proliferation negative regulation of hydrolase activity protein homotetramerization cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion; protein-containing complex angiostatin binding ATPase binding ATPase inhibitor activity calmodulin binding identical protein binding protein homodimerization activity structural molecule activity Bos taurus 3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide MAATALAART MAATALAARTRQAVWSVWAMQGRGFGSESGDNVRSSAGAVRDAGGAFGKREQAEEERYFRARAKEQLAALKKHHENEISHHAKEIERLQKEIERHKQSIKKLKQSEDDD |
negative regulation of ATP-dependent activity | mitochondrion | ATPase inhibitor activity enzyme inhibitor activity molecular function inhibitor activity | Saccharomyces cerevisiae | 3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide | MLPRSALARS | MLPRSALARSLQLQRGVAARFYSEGSTGTPRGSGSEDSFVKRERATEDFFVRQREKEQLRHLKEQLEKQRKKIDSLENKIDSMTK | negative regulation of ATP-dependent activity mitochondrion ATPase inhibitor activity enzyme inhibitor activity molecular function inhibitor activity Saccharomyces cerevisiae 3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide MLPRSALARS MLPRSALARSLQLQRGVAARFYSEGSTGTPRGSGSEDSFVKRERATEDFFVRQREKEQLRHLKEQLEKQRKKIDSLENKIDSMTK |
MAPK cascade myoblast differentiation positive regulation of endothelial cell proliferation Ras protein signal transduction | cytosol; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; Golgi membrane; membrane; plasma membrane; tertiary granule membrane | G protein activity GDP binding GTP binding GTPase activity protein-containing complex binding | Homo sapiens | 3D-structure Acetylation Cell membrane Disease variant Glycoprotein Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Proto-oncogene Reference proteome Ubl conjugation | MTEYKLVVVG | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM | MAPK cascade myoblast differentiation positive regulation of endothelial cell proliferation Ras protein signal transduction cytosol; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; Golgi membrane; membrane; plasma membrane; tertiary granule membrane G protein activity GDP binding GTP binding GTPase activity protein-containing complex binding Homo sapiens 3D-structure Acetylation Cell membrane Disease variant Glycoprotein Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Proto-oncogene Reference proteome Ubl conjugation MTEYKLVVVG MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM |
actin cytoskeleton organization epithelial tube branching involved in lung morphogenesis forebrain astrocyte development gene expression glial cell proliferation homeostasis of number of cells within a tissue MAPK cascade negative regulation of epithelial cell differentiation negative regulation of neuron apoptotic process neuron apoptotic process positive regulation of gene expression positive regulation of glial cell proliferation positive regulation of protein phosphorylation positive regulation of Rac protein signal transduction Rac protein signal transduction Ras protein signal transduction regulation of long-term neuronal synaptic plasticity regulation of synaptic transmission, GABAergic skeletal muscle cell differentiation striated muscle cell differentiation type I pneumocyte differentiation visual learning | cytoplasm; cytoplasmic side of plasma membrane; cytosol; endoplasmic reticulum membrane; focal adhesion; Golgi membrane; membrane; mitochondrial outer membrane; plasma membrane | G protein activity GDP binding GTP binding GTPase activity identical protein binding protein-containing complex binding protein-membrane adaptor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cardiomyopathy Cell membrane Cytoplasm Deafness Direct protein sequencing Disease variant Ectodermal dysplasia Glycoprotein GTP-binding Hydrolase Intellectual disability Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Proto-oncogene Reference proteome Ubl conjugation | MTEYKLVVVG | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM | actin cytoskeleton organization epithelial tube branching involved in lung morphogenesis forebrain astrocyte development gene expression glial cell proliferation homeostasis of number of cells within a tissue MAPK cascade negative regulation of epithelial cell differentiation negative regulation of neuron apoptotic process neuron apoptotic process positive regulation of gene expression positive regulation of glial cell proliferation positive regulation of protein phosphorylation positive regulation of Rac protein signal transduction Rac protein signal transduction Ras protein signal transduction regulation of long-term neuronal synaptic plasticity regulation of synaptic transmission, GABAergic skeletal muscle cell differentiation striated muscle cell differentiation type I pneumocyte differentiation visual learning cytoplasm; cytoplasmic side of plasma membrane; cytosol; endoplasmic reticulum membrane; focal adhesion; Golgi membrane; membrane; mitochondrial outer membrane; plasma membrane G protein activity GDP binding GTP binding GTPase activity identical protein binding protein-containing complex binding protein-membrane adaptor activity Homo sapiens 3D-structure Acetylation Alternative splicing Cardiomyopathy Cell membrane Cytoplasm Deafness Direct protein sequencing Disease variant Ectodermal dysplasia Glycoprotein GTP-binding Hydrolase Intellectual disability Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Proto-oncogene Reference proteome Ubl conjugation MTEYKLVVVG MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM |
adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase activity protein localization to bud neck | cell periphery; cytoplasm; nucleus; plasma membrane | G protein activity GDP binding GTP binding GTPase activity | Saccharomyces cerevisiae | Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Reference proteome | MQGNKSTIRE | MQGNKSTIREYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEIRDSELTSSATADREKKNNGSYVLDNSLTNAGTGSSSKSAVNHNGETTKRTDEKNYVNQNNNNEGNTKYSSNGNGNRSDISRGNQNNALNSRSKQSAEPQKNSSANARKESSGGCCIIC | adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase activity protein localization to bud neck cell periphery; cytoplasm; nucleus; plasma membrane G protein activity GDP binding GTP binding GTPase activity Saccharomyces cerevisiae Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Reference proteome MQGNKSTIRE MQGNKSTIREYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEIRDSELTSSATADREKKNNGSYVLDNSLTNAGTGSSSKSAVNHNGETTKRTDEKNYVNQNNNNEGNTKYSSNGNGNRSDISRGNQNNALNSRSKQSAEPQKNSSANARKESSGGCCIIC |
ascospore formation cytoplasm to vacuole transport by the Cvt pathway macroautophagy positive regulation of pseudohyphal growth positive regulation of transcription by galactose protein localization to bud neck regulation of cytoplasmic mRNA processing body assembly regulation of protein localization signal transduction | cell periphery; endoplasmic reticulum membrane; mitochondrion; nucleus; plasma membrane | G protein activity GDP binding GTP binding GTPase activity | Saccharomyces cerevisiae | Cell membrane Direct protein sequencing GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Reference proteome Ubl conjugation | MPLNKSNIRE | MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS | ascospore formation cytoplasm to vacuole transport by the Cvt pathway macroautophagy positive regulation of pseudohyphal growth positive regulation of transcription by galactose protein localization to bud neck regulation of cytoplasmic mRNA processing body assembly regulation of protein localization signal transduction cell periphery; endoplasmic reticulum membrane; mitochondrion; nucleus; plasma membrane G protein activity GDP binding GTP binding GTPase activity Saccharomyces cerevisiae Cell membrane Direct protein sequencing GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Reference proteome Ubl conjugation MPLNKSNIRE MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCIIS |
autophagosome assembly COPII-coated vesicle budding cytoplasm to vacuole transport by the Cvt pathway early endosome to Golgi transport endocytic recycling endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle budding Golgi vesicle docking intracellular protein transport macroautophagy pre-mRNA catabolic process protein localization to phagophore assembly site regulation of endoplasmic reticulum unfolded protein response reticulophagy retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum SNARE complex assembly SNARE complex disassembly | cis-Golgi network; cytoplasmic vesicle; cytosol; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; Golgi stack; mitochondrion; phagophore assembly site; phagophore assembly site membrane | GTP binding GTPase activity SNARE binding | Saccharomyces cerevisiae | 3D-structure Acetylation Autophagy Cytoplasm Direct protein sequencing Endoplasmic reticulum ER-Golgi transport Golgi apparatus GTP-binding Isopeptide bond Lipoprotein Membrane Nucleotide-binding Palmitate Phosphoprotein Prenylation Protein transport Reference proteome Transport Ubl conjugation | MNSEYDYLFK | MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQEIDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKKEDKGNVNLKGQSLTNTGGGCC | autophagosome assembly COPII-coated vesicle budding cytoplasm to vacuole transport by the Cvt pathway early endosome to Golgi transport endocytic recycling endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle budding Golgi vesicle docking intracellular protein transport macroautophagy pre-mRNA catabolic process protein localization to phagophore assembly site regulation of endoplasmic reticulum unfolded protein response reticulophagy retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum SNARE complex assembly SNARE complex disassembly cis-Golgi network; cytoplasmic vesicle; cytosol; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; Golgi stack; mitochondrion; phagophore assembly site; phagophore assembly site membrane GTP binding GTPase activity SNARE binding Saccharomyces cerevisiae 3D-structure Acetylation Autophagy Cytoplasm Direct protein sequencing Endoplasmic reticulum ER-Golgi transport Golgi apparatus GTP-binding Isopeptide bond Lipoprotein Membrane Nucleotide-binding Palmitate Phosphoprotein Prenylation Protein transport Reference proteome Transport Ubl conjugation MNSEYDYLFK MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQEIDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKKEDKGNVNLKGQSLTNTGGGCC |
cell division G1/S transition of mitotic cell cycle negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II rRNA transcription | chromatin; cytoplasm; MBF transcription complex; nucleus; SBF transcription complex | DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Schizosaccharomyces pombe | ANK repeat Cell cycle Cell division Mitosis Nucleus Phosphoprotein Reference proteome Repeat | MASANFIRQF | MASANFIRQFELGNDSFSYQKRPEDEPSQPLSNRNINKLNDSSTLKDSSSRIFINSQVLRDGRPVELYAVECSGMKYMELSCGDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQPLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSPLRNHNFSNPSKSSKNGVHTINNMQSSPSPSSSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDLHPSSQLNDNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTSKDILTSIFLDVNFADSSALEAKLSDSLDLDVPIDELGHAALHWAAAVAKMPLLQALIHKGANPLRGNLTGETALMRSVLVTNHLNQNSFGDLLDLLYASLPCTDRAGRTVVHHICLTAGIKGRGSASRYYLETLLNWAKKHASGNNGYMLKDFINYLNHQDKNGDTALNIAARIGNKNIVEVLMQAGASAYIPNRAGLSVANFGIFVENALKQPEDSKQTKVSLMSENLSSKEKTAVPPRQKSRDIIASVTDVISSLDKDFQDEMAAKQSMIDSAYTQLRESTKKLSDLREQLHVSETQRTLFLELRQRCKNLMTSIEEQKSELSNLYESFDPNGIHDSLSLDADAPFTVNENNNKNLSIAELKFQVAAYERNEARLNELANKLWQRNSNIKSKCRRVVSLCTGVDESRVDSLLESLLQAVESDGQQGEVDMGRVAGFLRVVKEHQA | cell division G1/S transition of mitotic cell cycle negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II rRNA transcription chromatin; cytoplasm; MBF transcription complex; nucleus; SBF transcription complex DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Schizosaccharomyces pombe ANK repeat Cell cycle Cell division Mitosis Nucleus Phosphoprotein Reference proteome Repeat MASANFIRQF MASANFIRQFELGNDSFSYQKRPEDEPSQPLSNRNINKLNDSSTLKDSSSRIFINSQVLRDGRPVELYAVECSGMKYMELSCGDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQPLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSPLRNHNFSNPSKSSKNGVHTINNMQSSPSPSSSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDLHPSSQLNDNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTSKDILTSIFLDVNFADSSALEAKLSDSLDLDVPIDELGHAALHWAAAVAKMPLLQALIHKGANPLRGNLTGETALMRSVLVTNHLNQNSFGDLLDLLYASLPCTDRAGRTVVHHICLTAGIKGRGSASRYYLETLLNWAKKHASGNNGYMLKDFINYLNHQDKNGDTALNIAARIGNKNIVEVLMQAGASAYIPNRAGLSVANFGIFVENALKQPEDSKQTKVSLMSENLSSKEKTAVPPRQKSRDIIASVTDVISSLDKDFQDEMAAKQSMIDSAYTQLRESTKKLSDLREQLHVSETQRTLFLELRQRCKNLMTSIEEQKSELSNLYESFDPNGIHDSLSLDADAPFTVNENNNKNLSIAELKFQVAAYERNEARLNELANKLWQRNSNIKSKCRRVVSLCTGVDESRVDSLLESLLQAVESDGQQGEVDMGRVAGFLRVVKEHQA |
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation mammary gland alveolus development negative regulation of apoptotic process positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of MAPK cascade positive regulation of mitotic nuclear division positive regulation of peptidyl-tyrosine phosphorylation response to xenobiotic stimulus | basolateral plasma membrane; cell surface; cytoplasmic vesicle; extracellular space; perinuclear region of cytoplasm | epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity | Rattus norvegicus | Cell membrane Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix | MVPAAGQLAL | MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV | angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation mammary gland alveolus development negative regulation of apoptotic process positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of MAPK cascade positive regulation of mitotic nuclear division positive regulation of peptidyl-tyrosine phosphorylation response to xenobiotic stimulus basolateral plasma membrane; cell surface; cytoplasmic vesicle; extracellular space; perinuclear region of cytoplasm epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity Rattus norvegicus Cell membrane Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix MVPAAGQLAL MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV |
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation intracellular signal transduction mammary gland alveolus development positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of MAPK cascade positive regulation of mitotic nuclear division positive regulation of peptidyl-tyrosine phosphorylation | basolateral plasma membrane; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasmic vesicle; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; extracellular region; extracellular space; perinuclear region of cytoplasm; plasma membrane | epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix | MVPSAGQLAL | MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV | angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation intracellular signal transduction mammary gland alveolus development positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of MAPK cascade positive regulation of mitotic nuclear division positive regulation of peptidyl-tyrosine phosphorylation basolateral plasma membrane; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasmic vesicle; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; extracellular region; extracellular space; perinuclear region of cytoplasm; plasma membrane epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix MVPSAGQLAL MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV |
extrinsic apoptotic signaling pathway via death domain receptors memory modulation of chemical synaptic transmission negative regulation of cell population proliferation negative regulation of neuron apoptotic process nerve development nerve growth factor signaling pathway neuron projection morphogenesis peripheral nervous system development positive regulation of collateral sprouting positive regulation of DNA binding positive regulation of gene expression positive regulation of neuron differentiation positive regulation of peptidyl-serine phosphorylation positive regulation of Ras protein signal transduction regulation of neuron differentiation transmembrane receptor protein tyrosine kinase signaling pathway | axon; cytosol; dendrite; endosome lumen; extracellular region; extracellular space; Golgi lumen; synaptic vesicle | growth factor activity lipid binding metalloendopeptidase inhibitor activity nerve growth factor receptor binding | Homo sapiens | 3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endosome Glycoprotein Growth factor Lipid-binding Metalloenzyme inhibitor Metalloprotease inhibitor Neurodegeneration Neuropathy Protease inhibitor Reference proteome Secreted Signal | MSMLFYTLIT | MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA | extrinsic apoptotic signaling pathway via death domain receptors memory modulation of chemical synaptic transmission negative regulation of cell population proliferation negative regulation of neuron apoptotic process nerve development nerve growth factor signaling pathway neuron projection morphogenesis peripheral nervous system development positive regulation of collateral sprouting positive regulation of DNA binding positive regulation of gene expression positive regulation of neuron differentiation positive regulation of peptidyl-serine phosphorylation positive regulation of Ras protein signal transduction regulation of neuron differentiation transmembrane receptor protein tyrosine kinase signaling pathway axon; cytosol; dendrite; endosome lumen; extracellular region; extracellular space; Golgi lumen; synaptic vesicle growth factor activity lipid binding metalloendopeptidase inhibitor activity nerve growth factor receptor binding Homo sapiens 3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endosome Glycoprotein Growth factor Lipid-binding Metalloenzyme inhibitor Metalloprotease inhibitor Neurodegeneration Neuropathy Protease inhibitor Reference proteome Secreted Signal MSMLFYTLIT MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA |
cell-cell signaling negative regulation of neuron migration regulation of gene expression regulation of ovarian follicle development reproduction response to ethanol response to steroid hormone signal transduction | extracellular region; extracellular space | gonadotropin hormone-releasing hormone activity gonadotropin-releasing hormone receptor binding hormone activity | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disease variant Hormone Hypogonadotropic hypogonadism Kallmann syndrome Pharmaceutical Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MKPIQKLLAG | MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI | cell-cell signaling negative regulation of neuron migration regulation of gene expression regulation of ovarian follicle development reproduction response to ethanol response to steroid hormone signal transduction extracellular region; extracellular space gonadotropin hormone-releasing hormone activity gonadotropin-releasing hormone receptor binding hormone activity Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disease variant Hormone Hypogonadotropic hypogonadism Kallmann syndrome Pharmaceutical Pyrrolidone carboxylic acid Reference proteome Secreted Signal MKPIQKLLAG MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI |
adult walking behavior eating behavior histamine metabolic process hormone-mediated signaling pathway negative regulation of feeding behavior negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion positive regulation of insulin secretion response to corticosterone response to ethanol response to glucose response to hypoxia response to organic cyclic compound | extracellular region; secretory granule | thyrotropin-releasing hormone activity | Rattus norvegicus | Amidation Cleavage on pair of basic residues Hormone Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal | MPGPWLLLAL | MPGPWLLLALALIFTLTGIPESCALPEAAQEEGAVTPDLPGLENVQVRPERRFLWKDLQRVRGDLGAALDSWITKRQHPGKREEEEKDIEAEERGDLGEGGAWRLHKRQHPGRRANQDKYSWADEEDSDWMPRSWLPDFFLDSWFSDVPQVKRQHPGRRSFPWMESDVTKRQHPGRRFIDPELQRSWEEKEGEGVLMPEKRQHPGKRALGHPCGPQGTCGQTGLLQLLGDLSRGQETLVKQSPQVEPWDKEPLEE | adult walking behavior eating behavior histamine metabolic process hormone-mediated signaling pathway negative regulation of feeding behavior negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion positive regulation of insulin secretion response to corticosterone response to ethanol response to glucose response to hypoxia response to organic cyclic compound extracellular region; secretory granule thyrotropin-releasing hormone activity Rattus norvegicus Amidation Cleavage on pair of basic residues Hormone Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal MPGPWLLLAL MPGPWLLLALALIFTLTGIPESCALPEAAQEEGAVTPDLPGLENVQVRPERRFLWKDLQRVRGDLGAALDSWITKRQHPGKREEEEKDIEAEERGDLGEGGAWRLHKRQHPGRRANQDKYSWADEEDSDWMPRSWLPDFFLDSWFSDVPQVKRQHPGRRSFPWMESDVTKRQHPGRRFIDPELQRSWEEKEGEGVLMPEKRQHPGKRALGHPCGPQGTCGQTGLLQLLGDLSRGQETLVKQSPQVEPWDKEPLEE |
aortic valve morphogenesis cardiac conduction system development cardiac muscle hypertrophy in response to stress cGMP biosynthetic process cGMP-mediated signaling female pregnancy negative regulation of JUN kinase activity negative regulation of systemic arterial blood pressure neuropeptide signaling pathway positive regulation of cardiac muscle contraction positive regulation of delayed rectifier potassium channel activity positive regulation of heart rate positive regulation of potassium ion export across plasma membrane protein folding receptor guanylyl cyclase signaling pathway regulation of atrial cardiac muscle cell membrane repolarization regulation of blood pressure regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of high voltage-gated calcium channel activity response to muscle stretch sodium ion export across plasma membrane vasodilation | cell projection; collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; perikaryon; protein-containing complex | hormone activity hormone receptor binding neuropeptide hormone activity neuropeptide receptor binding signaling receptor binding | Homo sapiens | 3D-structure Atrial fibrillation Cardiomyopathy Cell projection Direct protein sequencing Disease variant Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal Vasoactive Vasodilator | MSSFSTTTVS | MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY | aortic valve morphogenesis cardiac conduction system development cardiac muscle hypertrophy in response to stress cGMP biosynthetic process cGMP-mediated signaling female pregnancy negative regulation of JUN kinase activity negative regulation of systemic arterial blood pressure neuropeptide signaling pathway positive regulation of cardiac muscle contraction positive regulation of delayed rectifier potassium channel activity positive regulation of heart rate positive regulation of potassium ion export across plasma membrane protein folding receptor guanylyl cyclase signaling pathway regulation of atrial cardiac muscle cell membrane repolarization regulation of blood pressure regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of high voltage-gated calcium channel activity response to muscle stretch sodium ion export across plasma membrane vasodilation cell projection; collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; perikaryon; protein-containing complex hormone activity hormone receptor binding neuropeptide hormone activity neuropeptide receptor binding signaling receptor binding Homo sapiens 3D-structure Atrial fibrillation Cardiomyopathy Cell projection Direct protein sequencing Disease variant Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal Vasoactive Vasodilator MSSFSTTTVS MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY |
intracellular protein transport neuropeptide signaling pathway peptide hormone processing regulation of hormone secretion | extracellular region; secretory granule | enzyme inhibitor activity enzyme regulator activity unfolded protein binding | Sus scrofa | Chaperone Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neuropeptide Phosphoprotein Reference proteome Secreted Signal Sulfation Transport | MVSTMLSGLV | MVSTMLSGLVLWLTFGWTPALAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNTPKDFSEDQGYPDPPNPCPIGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE | intracellular protein transport neuropeptide signaling pathway peptide hormone processing regulation of hormone secretion extracellular region; secretory granule enzyme inhibitor activity enzyme regulator activity unfolded protein binding Sus scrofa Chaperone Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neuropeptide Phosphoprotein Reference proteome Secreted Signal Sulfation Transport MVSTMLSGLV MVSTMLSGLVLWLTFGWTPALAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNTPKDFSEDQGYPDPPNPCPIGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE |
positive regulation of cold-induced thermogenesis response to estrogen | extracellular space; secretory granule | neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding | Bos taurus | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal | MAGSSLACCL | MAGSSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDVRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDPEAAFSQH | positive regulation of cold-induced thermogenesis response to estrogen extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding Bos taurus 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal MAGSSLACCL MAGSSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDVRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDPEAAFSQH |
positive regulation of cold-induced thermogenesis signal transduction | extracellular region; extracellular space; secretory granule | neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pharmaceutical Reference proteome Secreted Signal | MAGPSLACCL | MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR | positive regulation of cold-induced thermogenesis signal transduction extracellular region; extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pharmaceutical Reference proteome Secreted Signal MAGPSLACCL MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR |
vasoconstriction | extracellular space; secretory granule | neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding | Bos taurus | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor | MPDATLPACF | MPDATLPACFLSLLAFTSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGVGFPRRVRANDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY | vasoconstriction extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding Bos taurus 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor MPDATLPACF MPDATLPACFLSLLAFTSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGVGFPRRVRANDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY |
vasoconstriction | extracellular space; secretory granule | neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding | Sus scrofa | Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor | MPDATLPACF | MPDATLPACFLGLLALTSACYFQNCPKGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGASFLRRARASDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY | vasoconstriction extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding Sus scrofa Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor MPDATLPACF MPDATLPACFLGLLALTSACYFQNCPKGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGASFLRRARASDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY |
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction | cytoplasm; extracellular region; extracellular space; secretory granule; secretory granule lumen | G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding | Homo sapiens | 3D-structure Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Obesity Phosphoprotein Reference proteome Secreted Signal | MPRSCCSRSG | MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE | calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction cytoplasm; extracellular region; extracellular space; secretory granule; secretory granule lumen G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding Homo sapiens 3D-structure Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Obesity Phosphoprotein Reference proteome Secreted Signal MPRSCCSRSG MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE |
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone | extracellular space; secretory granule | G protein-coupled receptor binding hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding | Bos taurus | Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation | MPRLCSSRSG | MPRLCSSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSSGVGGAAQKREEEVAVGEGPGPRGDDAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone extracellular space; secretory granule G protein-coupled receptor binding hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding Bos taurus Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation MPRLCSSRSG MPRLCSSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSSGVGGAAQKREEEVAVGEGPGPRGDDAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ |
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone | extracellular space; secretory granule | hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding | Ovis aries | Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation | MPRLCSSRSG | MPRLCSSRSGALLLVLLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSFGAGGAAQKREEEVAVGEGPGPRGDGAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone extracellular space; secretory granule hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding Ovis aries Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation MPRLCSSRSG MPRLCSSRSGALLLVLLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSFGAGGAAQKREEEVAVGEGPGPRGDGAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ |
neuropeptide signaling pathway regulation of corticosterone secretion | extracellular space; secretory granule | G protein-coupled receptor binding hormone activity | Sus scrofa | Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Reference proteome Secreted Signal | MPRLCGSRSG | MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ | neuropeptide signaling pathway regulation of corticosterone secretion extracellular space; secretory granule G protein-coupled receptor binding hormone activity Sus scrofa Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Reference proteome Secreted Signal MPRLCGSRSG MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ |
antimicrobial humoral immune response mediated by antimicrobial peptide calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis killing of cells of another organism modulation of process of another organism negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of neutrophil mediated killing of fungus positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction | cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule | G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding | Mus musculus | Acetylation Amidation Cleavage on pair of basic residues Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MPRFCYSRSG | MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ | antimicrobial humoral immune response mediated by antimicrobial peptide calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis killing of cells of another organism modulation of process of another organism negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of neutrophil mediated killing of fungus positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding Mus musculus Acetylation Amidation Cleavage on pair of basic residues Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MPRFCYSRSG MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ |
calcium-mediated signaling cell-cell signaling cellular pigmentation feeding behavior generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction | cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule | G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding | Rattus norvegicus | Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MPRFCNSRSG | MPRFCNSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNVHKKGQ | calcium-mediated signaling cell-cell signaling cellular pigmentation feeding behavior generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positive regulation of transcription by RNA polymerase II regulation of appetite regulation of blood pressure regulation of corticosterone secretion regulation of glycogen metabolic process response to melanocyte-stimulating hormone signal transduction cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding Rattus norvegicus Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MPRFCNSRSG MPRFCNSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNVHKKGQ |
neuropeptide signaling pathway | extracellular region | hormone activity | Macaca nemestrina | Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MPRSCCSRSG | MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSGSAHQKREDVAAGEDRGLLPEGGPEPRGDGAGPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRPRAGDGPDGPADDGAGPRADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGQ | neuropeptide signaling pathway extracellular region hormone activity Macaca nemestrina Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MPRSCCSRSG MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSGSAHQKREDVAAGEDRGLLPEGGPEPRGDGAGPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRPRAGDGPDGPADDGAGPRADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGQ |
aggressive behavior behavioral fear response cellular response to cAMP cellular response to oxidative stress cellular response to transforming growth factor beta stimulus cellular response to virus cellular response to vitamin D chemical synaptic transmission G protein-coupled opioid receptor signaling pathway general adaptation syndrome, behavioral process glial cell proliferation locomotory exploration behavior neuropeptide signaling pathway osteoblast differentiation positive regulation of behavioral fear response response to calcium ion response to epinephrine response to estradiol response to ethanol response to hypoxia response to lipopolysaccharide response to nicotine response to toxic substance sensory perception sensory perception of pain signal transduction startle response synaptic signaling via neuropeptide transmission of nerve impulse | axon terminus; cell body fiber; chromaffin granule lumen; dendrite; endoplasmic reticulum lumen; extracellular region; neuronal cell body; neuronal dense core vesicle lumen; perikaryon; plasma membrane; symmetric synapse; synaptic vesicle lumen | neuropeptide hormone activity opioid peptide activity opioid receptor binding | Homo sapiens | 3D-structure Cleavage on pair of basic residues Cytoplasmic vesicle Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal | MARFLTLCTW | MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF | aggressive behavior behavioral fear response cellular response to cAMP cellular response to oxidative stress cellular response to transforming growth factor beta stimulus cellular response to virus cellular response to vitamin D chemical synaptic transmission G protein-coupled opioid receptor signaling pathway general adaptation syndrome, behavioral process glial cell proliferation locomotory exploration behavior neuropeptide signaling pathway osteoblast differentiation positive regulation of behavioral fear response response to calcium ion response to epinephrine response to estradiol response to ethanol response to hypoxia response to lipopolysaccharide response to nicotine response to toxic substance sensory perception sensory perception of pain signal transduction startle response synaptic signaling via neuropeptide transmission of nerve impulse axon terminus; cell body fiber; chromaffin granule lumen; dendrite; endoplasmic reticulum lumen; extracellular region; neuronal cell body; neuronal dense core vesicle lumen; perikaryon; plasma membrane; symmetric synapse; synaptic vesicle lumen neuropeptide hormone activity opioid peptide activity opioid receptor binding Homo sapiens 3D-structure Cleavage on pair of basic residues Cytoplasmic vesicle Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal MARFLTLCTW MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF |
aggressive behavior behavioral fear response chemical synaptic transmission defense response to bacterium G protein-coupled opioid receptor signaling pathway locomotory behavior neuropeptide signaling pathway sensory perception sensory perception of pain startle response transmission of nerve impulse | axon terminus; chromaffin granule lumen; dendrite; extracellular region; neuronal cell body; plasma membrane | opioid peptide activity opioid receptor binding | Bos taurus | 3D-structure Antibiotic Antimicrobial Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal | MARFLGLCTW | MARFLGLCTWLLALGPGLLATVRAECSQDCATCSYRLARPTDLNPLACTLECEGKLPSLKTWETCKELLQLTKLELPPDATSALSKQEESHLLAKKYGGFMKRYGGFMKKMDELYPLEVEEEANGGEVLGKRYGGFMKKDAEEDDGLGNSSNLLKELLGAGDQREGSLHQEGSDAEDVSKRYGGFMRGLKRSPHLEDETKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEPLPSEEEGESYSKEVPEMEKRYGGFMRF | aggressive behavior behavioral fear response chemical synaptic transmission defense response to bacterium G protein-coupled opioid receptor signaling pathway locomotory behavior neuropeptide signaling pathway sensory perception sensory perception of pain startle response transmission of nerve impulse axon terminus; chromaffin granule lumen; dendrite; extracellular region; neuronal cell body; plasma membrane opioid peptide activity opioid receptor binding Bos taurus 3D-structure Antibiotic Antimicrobial Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal MARFLGLCTW MARFLGLCTWLLALGPGLLATVRAECSQDCATCSYRLARPTDLNPLACTLECEGKLPSLKTWETCKELLQLTKLELPPDATSALSKQEESHLLAKKYGGFMKRYGGFMKKMDELYPLEVEEEANGGEVLGKRYGGFMKKDAEEDDGLGNSSNLLKELLGAGDQREGSLHQEGSDAEDVSKRYGGFMRGLKRSPHLEDETKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEPLPSEEEGESYSKEVPEMEKRYGGFMRF |
chemical synaptic transmission neuropeptide signaling pathway sensory perception | axon terminus; dendrite; extracellular region; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; plasma membrane | opioid peptide activity opioid receptor binding | Homo sapiens | 3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endorphin Neurodegeneration Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal Spinocerebellar ataxia | MAWQGLVLAA | MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA | chemical synaptic transmission neuropeptide signaling pathway sensory perception axon terminus; dendrite; extracellular region; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; plasma membrane opioid peptide activity opioid receptor binding Homo sapiens 3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endorphin Neurodegeneration Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal Spinocerebellar ataxia MAWQGLVLAA MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA |
chemical synaptic transmission neuropeptide signaling pathway sensory perception | axon terminus; dendrite; extracellular region; neuronal cell body; plasma membrane | opioid peptide activity opioid receptor binding | Sus scrofa | Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal | MAWQGLLLAA | MAWQGLLLAACLLVLPSTMADCLSGCSLCAVKTQDGPKPINPLICSLECQAALQPAEEWERCQGLLSFLAPLSLGLEGKEDLESKAALEEPSSELVKYMGPFLKELEKNRFLLSTPAEETSLSRSLVEKLRSLPGRLGEETESELMGDAQQNDGAMEAAALDSSVEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDRDKVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYYEELFDV | chemical synaptic transmission neuropeptide signaling pathway sensory perception axon terminus; dendrite; extracellular region; neuronal cell body; plasma membrane opioid peptide activity opioid receptor binding Sus scrofa Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal MAWQGLLLAA MAWQGLLLAACLLVLPSTMADCLSGCSLCAVKTQDGPKPINPLICSLECQAALQPAEEWERCQGLLSFLAPLSLGLEGKEDLESKAALEEPSSELVKYMGPFLKELEKNRFLLSTPAEETSLSRSLVEKLRSLPGRLGEETESELMGDAQQNDGAMEAAALDSSVEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDRDKVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYYEELFDV |
follicle-stimulating hormone secretion follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway hormone-mediated signaling pathway luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of cell migration positive regulation of cell population proliferation positive regulation of steroid biosynthetic process positive regulation of transcription by RNA polymerase II regulation of signaling receptor activity thyroid gland development thyroid hormone generation | extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen; pituitary gonadotropin complex | follicle-stimulating hormone activity hormone activity | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal | MDYYRKYAAI | MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS | follicle-stimulating hormone secretion follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway hormone-mediated signaling pathway luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of cell migration positive regulation of cell population proliferation positive regulation of steroid biosynthetic process positive regulation of transcription by RNA polymerase II regulation of signaling receptor activity thyroid gland development thyroid hormone generation extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen; pituitary gonadotropin complex follicle-stimulating hormone activity hormone activity Homo sapiens 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MDYYRKYAAI MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS |
cellular response to hormone stimulus developmental growth follicle-stimulating hormone secretion G protein-coupled receptor signaling pathway gonad development luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of steroid biosynthetic process regulation of signaling receptor activity thyroid gland development thyroid hormone generation | extracellular space; follicle-stimulating hormone complex; pituitary gonadotropin complex | follicle-stimulating hormone activity hormone activity | Mus musculus | Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal | MDYYRKYAAV | MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS | cellular response to hormone stimulus developmental growth follicle-stimulating hormone secretion G protein-coupled receptor signaling pathway gonad development luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of steroid biosynthetic process regulation of signaling receptor activity thyroid gland development thyroid hormone generation extracellular space; follicle-stimulating hormone complex; pituitary gonadotropin complex follicle-stimulating hormone activity hormone activity Mus musculus Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MDYYRKYAAV MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS |
anatomical structure morphogenesis cell-cell signaling G protein-coupled receptor signaling pathway response to calcium ion response to estrogen response to vitamin A | cytoplasm; extracellular region; extracellular space | hormone activity | Homo sapiens | 3D-structure Alternative splicing Congenital hypothyroidism Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Pharmaceutical Reference proteome Secreted Signal | MTALFLMSML | MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV | anatomical structure morphogenesis cell-cell signaling G protein-coupled receptor signaling pathway response to calcium ion response to estrogen response to vitamin A cytoplasm; extracellular region; extracellular space hormone activity Homo sapiens 3D-structure Alternative splicing Congenital hypothyroidism Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Pharmaceutical Reference proteome Secreted Signal MTALFLMSML MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV |
G protein-coupled receptor signaling pathway | cytoplasm; extracellular space | hormone activity | Bos taurus | Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal | MTATFLMSMI | MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI | G protein-coupled receptor signaling pathway cytoplasm; extracellular space hormone activity Bos taurus Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MTATFLMSMI MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI |
female gamete generation female pregnancy follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway positive regulation of bone resorption positive regulation of cell migration positive regulation of cell population proliferation positive regulation of gene expression positive regulation of steroid biosynthetic process positive regulation of transcription by RNA polymerase II progesterone biosynthetic process regulation of osteoclast differentiation regulation of signaling receptor activity Sertoli cell proliferation spermatogenesis transforming growth factor beta receptor signaling pathway | cytoplasm; extracellular region; extracellular space; follicle-stimulating hormone complex | follicle-stimulating hormone activity | Homo sapiens | 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Pharmaceutical Reference proteome Secreted Signal | MKTLQFFFLF | MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE | female gamete generation female pregnancy follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway positive regulation of bone resorption positive regulation of cell migration positive regulation of cell population proliferation positive regulation of gene expression positive regulation of steroid biosynthetic process positive regulation of transcription by RNA polymerase II progesterone biosynthetic process regulation of osteoclast differentiation regulation of signaling receptor activity Sertoli cell proliferation spermatogenesis transforming growth factor beta receptor signaling pathway cytoplasm; extracellular region; extracellular space; follicle-stimulating hormone complex follicle-stimulating hormone activity Homo sapiens 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Pharmaceutical Reference proteome Secreted Signal MKTLQFFFLF MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE |
cell-cell signaling G protein-coupled receptor signaling pathway hormone-mediated signaling pathway male gonad development progesterone biosynthetic process signal transduction | cytoplasm; extracellular region; extracellular space; Golgi lumen; pituitary gonadotropin complex | hormone activity signaling receptor binding | Homo sapiens | Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Reference proteome Secreted Signal | MEMLQGLLLL | MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL | cell-cell signaling G protein-coupled receptor signaling pathway hormone-mediated signaling pathway male gonad development progesterone biosynthetic process signal transduction cytoplasm; extracellular region; extracellular space; Golgi lumen; pituitary gonadotropin complex hormone activity signaling receptor binding Homo sapiens Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Reference proteome Secreted Signal MEMLQGLLLL MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL |
estradiol secretion | extracellular region | hormone activity | Ovis aries | Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal | MEMLQGLLLW | MEMLQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCLSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL | estradiol secretion extracellular region hormone activity Ovis aries Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MEMLQGLLLW MEMLQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCLSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL |
cell surface receptor signaling pathway female pregnancy lactation mammary gland development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of lactation positive regulation of miRNA transcription positive regulation of receptor signaling pathway via JAK-STAT prolactin signaling pathway response to nutrient levels | endosome lumen; extracellular region; extracellular space | hormone activity prolactin receptor binding | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal | MNIKGSPWKG | MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC | cell surface receptor signaling pathway female pregnancy lactation mammary gland development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of lactation positive regulation of miRNA transcription positive regulation of receptor signaling pathway via JAK-STAT prolactin signaling pathway response to nutrient levels endosome lumen; extracellular region; extracellular space hormone activity prolactin receptor binding Homo sapiens 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal MNIKGSPWKG MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC |
cell population proliferation cellular response to hormone stimulus circadian rhythm epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior multicellular organismal response to stress negative regulation of endothelial cell proliferation ovulation cycle parturition positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of lactation positive regulation of miRNA transcription positive regulation of receptor signaling pathway via JAK-STAT prolactin signaling pathway regulation of ossification regulation of receptor signaling pathway via JAK-STAT response to estradiol response to ethanol response to lipopolysaccharide response to macrophage colony-stimulating factor response to nutrient response to nutrient levels response to organic cyclic compound response to xenobiotic stimulus | extracellular region; extracellular space; secretory granule | hormone activity prolactin receptor binding | Rattus norvegicus | Direct protein sequencing Disulfide bond Hormone Lactation Phosphoprotein Reference proteome Secreted Signal | MNSQVSARKA | MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPELFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKVPPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKIISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRCQIVHKNNC | cell population proliferation cellular response to hormone stimulus circadian rhythm epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior multicellular organismal response to stress negative regulation of endothelial cell proliferation ovulation cycle parturition positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of epithelial cell proliferation positive regulation of lactation positive regulation of miRNA transcription positive regulation of receptor signaling pathway via JAK-STAT prolactin signaling pathway regulation of ossification regulation of receptor signaling pathway via JAK-STAT response to estradiol response to ethanol response to lipopolysaccharide response to macrophage colony-stimulating factor response to nutrient response to nutrient levels response to organic cyclic compound response to xenobiotic stimulus extracellular region; extracellular space; secretory granule hormone activity prolactin receptor binding Rattus norvegicus Direct protein sequencing Disulfide bond Hormone Lactation Phosphoprotein Reference proteome Secreted Signal MNSQVSARKA MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPELFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKVPPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKIISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRCQIVHKNNC |
cellular response to hypoxia female pregnancy lactation mammary gland development negative regulation of estrogen biosynthetic process negative regulation of hydrogen peroxide biosynthetic process negative regulation of nitric oxide biosynthetic process negative regulation of progesterone biosynthetic process positive regulation of cell population proliferation positive regulation of endothelial cell proliferation positive regulation of lactation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of vascular endothelial growth factor production response to nutrient levels | extracellular space | hormone activity prolactin receptor binding | Sus scrofa | Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal | MDNRGSSQKG | MDNRGSSQKGSLLLLLLLVSNLFLCKSVASLPICPSGAVNCQVSLRDLFDRAVILSHYIHNLSSEMFNEFDKRYAQGRGFITKAINSCHTSSLSTPEDKEQAQQIHHEVLLNLILRVLRSWNDPLYHLVTEVRGMQEAPDAILSRAIEIEEQNKRLLEGMEKIVGQVHPGIKENEVYSVWSGLPSLQMADEDTRLFAFYNLLHCLRRDSHKIDNYLKLLKCRIIYDSNC | cellular response to hypoxia female pregnancy lactation mammary gland development negative regulation of estrogen biosynthetic process negative regulation of hydrogen peroxide biosynthetic process negative regulation of nitric oxide biosynthetic process negative regulation of progesterone biosynthetic process positive regulation of cell population proliferation positive regulation of endothelial cell proliferation positive regulation of lactation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of vascular endothelial growth factor production response to nutrient levels extracellular space hormone activity prolactin receptor binding Sus scrofa Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal MDNRGSSQKG MDNRGSSQKGSLLLLLLLVSNLFLCKSVASLPICPSGAVNCQVSLRDLFDRAVILSHYIHNLSSEMFNEFDKRYAQGRGFITKAINSCHTSSLSTPEDKEQAQQIHHEVLLNLILRVLRSWNDPLYHLVTEVRGMQEAPDAILSRAIEIEEQNKRLLEGMEKIVGQVHPGIKENEVYSVWSGLPSLQMADEDTRLFAFYNLLHCLRRDSHKIDNYLKLLKCRIIYDSNC |
biosynthetic process blastocyst formation lactation negative regulation of apoptotic process negative regulation of luteinizing hormone secretion negative regulation of nitric oxide mediated signal transduction negative regulation of peptide hormone secretion peptide hormone secretion positive regulation of fatty acid biosynthetic process positive regulation of gene expression positive regulation of lactation | extracellular space | hormone activity prolactin receptor binding | Ovis aries | Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal | MDSKGSAQKG | MDSKGSAQKGSRLLLLLVVSNLLLCQGVVSTPVCPNGPGNCQVSLRDLFDRAVMVSHYIHNLSSEMFNEFDKRYAQGKGFITMALNSCHTSSLPTPEDKEQAQQTHHEVLMSLILGLLRSWNDPLYHLVTEVRGMKGVPDAILSRAIEIEEENKRLLEGMEMIFGQVIPGAKETEPYPVWSGLPSLQTKDEDARHSAFYNLLHCLRRDSSKIDTYLKLLNCRIIYNNNC | biosynthetic process blastocyst formation lactation negative regulation of apoptotic process negative regulation of luteinizing hormone secretion negative regulation of nitric oxide mediated signal transduction negative regulation of peptide hormone secretion peptide hormone secretion positive regulation of fatty acid biosynthetic process positive regulation of gene expression positive regulation of lactation extracellular space hormone activity prolactin receptor binding Ovis aries Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal MDSKGSAQKG MDSKGSAQKGSRLLLLLVVSNLLLCQGVVSTPVCPNGPGNCQVSLRDLFDRAVMVSHYIHNLSSEMFNEFDKRYAQGKGFITMALNSCHTSSLPTPEDKEQAQQTHHEVLMSLILGLLRSWNDPLYHLVTEVRGMKGVPDAILSRAIEIEEENKRLLEGMEMIFGQVIPGAKETEPYPVWSGLPSLQTKDEDARHSAFYNLLHCLRRDSSKIDTYLKLLNCRIIYNNNC |
animal organ development bone maturation cytokine-mediated signaling pathway growth hormone receptor signaling pathway positive regulation of activation of Janus kinase activity positive regulation of glucose transmembrane transport positive regulation of growth positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of MAP kinase activity positive regulation of multicellular organism growth positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein receptor signaling pathway via JAK-STAT response to estradiol response to nutrient levels | endosome lumen; extracellular region; extracellular space; growth hormone receptor complex | cytokine activity growth factor activity growth hormone receptor binding hormone activity metal ion binding prolactin receptor binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Dwarfism Hormone Metal-binding Pharmaceutical Phosphoprotein Reference proteome Secreted Signal Zinc | MATGSRTSLL | MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF | animal organ development bone maturation cytokine-mediated signaling pathway growth hormone receptor signaling pathway positive regulation of activation of Janus kinase activity positive regulation of glucose transmembrane transport positive regulation of growth positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of MAP kinase activity positive regulation of multicellular organism growth positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein receptor signaling pathway via JAK-STAT response to estradiol response to nutrient levels endosome lumen; extracellular region; extracellular space; growth hormone receptor complex cytokine activity growth factor activity growth hormone receptor binding hormone activity metal ion binding prolactin receptor binding Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Dwarfism Hormone Metal-binding Pharmaceutical Phosphoprotein Reference proteome Secreted Signal Zinc MATGSRTSLL MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels | endosome lumen; extracellular region; extracellular space | growth factor activity growth hormone receptor binding hormone activity | Homo sapiens | Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MAAGSRTSLL | MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF | animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels endosome lumen; extracellular region; extracellular space growth factor activity growth hormone receptor binding hormone activity Homo sapiens Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MAAGSRTSLL MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF |
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels | extracellular space | growth factor activity growth hormone receptor binding hormone activity metal ion binding | Sus scrofa | Direct protein sequencing Disulfide bond Hormone Metal-binding Phosphoprotein Reference proteome Secreted Signal Zinc | MAAGPRTSAL | MAAGPRTSALLAFALLCLPWTREVGAFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF | animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels extracellular space growth factor activity growth hormone receptor binding hormone activity metal ion binding Sus scrofa Direct protein sequencing Disulfide bond Hormone Metal-binding Phosphoprotein Reference proteome Secreted Signal Zinc MAAGPRTSAL MAAGPRTSALLAFALLCLPWTREVGAFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF |
activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure cellular response to nerve growth factor stimulus cellular response to tumor necrosis factor detection of temperature stimulus involved in sensory perception of pain embryo implantation feeding behavior inflammatory response monocyte chemotaxis negative regulation of bone resorption negative regulation of DNA-templated transcription negative regulation of ossification negative regulation of smooth muscle contraction neuropeptide signaling pathway ossification positive regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration response to heat response to pain smooth muscle contraction | extracellular region; extracellular space; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; terminal bouton | calcitonin receptor binding hormone activity identical protein binding | Homo sapiens | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal | MGFQKFSPFL | MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN | activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure cellular response to nerve growth factor stimulus cellular response to tumor necrosis factor detection of temperature stimulus involved in sensory perception of pain embryo implantation feeding behavior inflammatory response monocyte chemotaxis negative regulation of bone resorption negative regulation of DNA-templated transcription negative regulation of ossification negative regulation of smooth muscle contraction neuropeptide signaling pathway ossification positive regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration response to heat response to pain smooth muscle contraction extracellular region; extracellular space; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; terminal bouton calcitonin receptor binding hormone activity identical protein binding Homo sapiens 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal MGFQKFSPFL MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN |
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expression phosphate ion homeostasis positive regulation of bone mineralization positive regulation of cell proliferation in bone marrow positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of inositol phosphate biosynthetic process positive regulation of osteoclast proliferation positive regulation of signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II | extracellular space | hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding | Bos taurus | 3D-structure Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal | MMSAKDMVKV | MMSAKDMVKVMIVMLAICFLARSDGKSVKKRAVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNFVALGASIAYRDGSSQRPRKKEDNVLVESHQKSLGEADKADVDVLIKAKPQ | adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expression phosphate ion homeostasis positive regulation of bone mineralization positive regulation of cell proliferation in bone marrow positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of inositol phosphate biosynthetic process positive regulation of osteoclast proliferation positive regulation of signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II extracellular space hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding Bos taurus 3D-structure Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal MMSAKDMVKV MMSAKDMVKVMIVMLAICFLARSDGKSVKKRAVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNFVALGASIAYRDGSSQRPRKKEDNVLVESHQKSLGEADKADVDVLIKAKPQ |
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expression phosphate ion homeostasis positive regulation of bone mineralization positive regulation of cell proliferation in bone marrow positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of inositol phosphate biosynthetic process positive regulation of osteoclast proliferation positive regulation of signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II | extracellular space | hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding | Sus scrofa | Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal | MMSAKDTVKV | MMSAKDTVKVMVVMLAICFLARSDGKPIKKRSVSEIQLMHNLGKHLSSLERVEWLRKKLQDVHNFVALGASIVHRDGGSQRPRKKEDNVLVESHQKSLGEADKAAVDVLIKAKPQ | adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expression phosphate ion homeostasis positive regulation of bone mineralization positive regulation of cell proliferation in bone marrow positive regulation of glucose import positive regulation of glycogen biosynthetic process positive regulation of inositol phosphate biosynthetic process positive regulation of osteoclast proliferation positive regulation of signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II extracellular space hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding Sus scrofa Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal MMSAKDTVKV MMSAKDTVKVMVVMLAICFLARSDGKPIKKRSVSEIQLMHNLGKHLSSLERVEWLRKKLQDVHNFVALGASIVHRDGGSQRPRKKEDNVLVESHQKSLGEADKAAVDVLIKAKPQ |
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis lactate biosynthetic process lipid biosynthetic process negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity | cytoplasm; extracellular space; plasma membrane | glucagon receptor binding hormone activity identical protein binding | Bos taurus | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal | MKSLYFVAGL | MKSLYFVAGLFVMLVQGSWQRSLQNTEEKSSSFPAPQTDPLGDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVNIVEELRRRHADGSFSDEMNTVLDSLATRDFINWLLQTKITDRK | adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis lactate biosynthetic process lipid biosynthetic process negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity cytoplasm; extracellular space; plasma membrane glucagon receptor binding hormone activity identical protein binding Bos taurus 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal MKSLYFVAGL MKSLYFVAGLFVMLVQGSWQRSLQNTEEKSSSFPAPQTDPLGDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVNIVEELRRRHADGSFSDEMNTVLDSLATRDFINWLLQTKITDRK |
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity | cytoplasm; extracellular space; plasma membrane | glucagon receptor binding hormone activity identical protein binding | Sus scrofa | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal | MKTIYFVAGL | MKTIYFVAGLFVMLVQGSWQRSLQNTEEKSRSFPAPQTDPLDDPDQMTEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVTIVEELRRRHADGSFSDEMNTVLDNLATRDFINWLLHTKITDSL | adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity cytoplasm; extracellular space; plasma membrane glucagon receptor binding hormone activity identical protein binding Sus scrofa 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal MKTIYFVAGL MKTIYFVAGLFVMLVQGSWQRSLQNTEEKSRSFPAPQTDPLDDPDQMTEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVTIVEELRRRHADGSFSDEMNTVLDNLATRDFINWLLHTKITDSL |
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus feeding behavior G protein-coupled receptor signaling pathway gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity | endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane; secretory granule lumen | glucagon receptor binding hormone activity identical protein binding signaling receptor binding | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Phosphoprotein Reference proteome Secreted Signal | MKSIYFVAGL | MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK | adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus feeding behavior G protein-coupled receptor signaling pathway gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis positive regulation of calcium ion import positive regulation of ERK1 and ERK2 cascade positive regulation of gluconeogenesis positive regulation of histone H3-K4 methylation positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of peptidyl-serine phosphorylation positive regulation of peptidyl-threonine phosphorylation protein kinase A signaling regulation of insulin secretion response to activity endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane; secretory granule lumen glucagon receptor binding hormone activity identical protein binding signaling receptor binding Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Phosphoprotein Reference proteome Secreted Signal MKSIYFVAGL MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK |
adenylate cyclase-activating G protein-coupled receptor signaling pathway body fluid secretion epinephrine secretion G protein-coupled receptor signaling pathway learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cell population proliferation positive regulation of endothelial cell proliferation positive regulation of epinephrine secretion positive regulation of penile erection positive regulation of protein catabolic process prolactin secretion regulation of protein localization | extracellular region; neuron projection | hormone activity neuropeptide hormone activity peptide hormone receptor binding | Homo sapiens | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal | MDTRNKAQLL | MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK | adenylate cyclase-activating G protein-coupled receptor signaling pathway body fluid secretion epinephrine secretion G protein-coupled receptor signaling pathway learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of cell population proliferation positive regulation of endothelial cell proliferation positive regulation of epinephrine secretion positive regulation of penile erection positive regulation of protein catabolic process prolactin secretion regulation of protein localization extracellular region; neuron projection hormone activity neuropeptide hormone activity peptide hormone receptor binding Homo sapiens 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal MDTRNKAQLL MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK |
adenylate cyclase-activating G protein-coupled receptor signaling pathway epinephrine secretion learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of endothelial cell proliferation positive regulation of epinephrine secretion positive regulation of penile erection positive regulation of protein catabolic process prolactin secretion regulation of protein localization regulation of signal transduction | extracellular region; neuron projection; neuronal cell body | hormone activity neuropeptide hormone activity peptide hormone receptor binding signaling receptor binding | Rattus norvegicus | Amidation Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MESRSKPQFL | MESRSKPQFLAILTLFSVLFSQSLAWPLYGPPSSVRLDDRLQFEGAGDPDQVSLKADSDILQNALAENDTPYYDVSRNARHADGVFTSDYSRLLGQISAKKYLESLIGKRISSSISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGDSPDFLEELEK | adenylate cyclase-activating G protein-coupled receptor signaling pathway epinephrine secretion learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of endothelial cell proliferation positive regulation of epinephrine secretion positive regulation of penile erection positive regulation of protein catabolic process prolactin secretion regulation of protein localization regulation of signal transduction extracellular region; neuron projection; neuronal cell body hormone activity neuropeptide hormone activity peptide hormone receptor binding signaling receptor binding Rattus norvegicus Amidation Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MESRSKPQFL MESRSKPQFLAILTLFSVLFSQSLAWPLYGPPSSVRLDDRLQFEGAGDPDQVSLKADSDILQNALAENDTPYYDVSRNARHADGVFTSDYSRLLGQISAKKYLESLIGKRISSSISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGDSPDFLEELEK |
adenohypophysis development adenylate cyclase-activating G protein-coupled receptor signaling pathway cell-cell signaling growth hormone secretion multicellular organism growth positive regulation of cell population proliferation positive regulation of circadian sleep/wake cycle, REM sleep positive regulation of growth hormone secretion positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of multicellular organism growth response to food | extracellular region; extracellular space; perikaryon; terminal bouton | growth hormone-releasing hormone activity growth hormone-releasing hormone receptor binding neuropeptide hormone activity peptide hormone receptor binding | Homo sapiens | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Pharmaceutical Reference proteome Secreted Signal | MPLWVFFFVI | MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARLGRQVDSMWAEQKQMELESILVALLQKHSRNSQG | adenohypophysis development adenylate cyclase-activating G protein-coupled receptor signaling pathway cell-cell signaling growth hormone secretion multicellular organism growth positive regulation of cell population proliferation positive regulation of circadian sleep/wake cycle, REM sleep positive regulation of growth hormone secretion positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of multicellular organism growth response to food extracellular region; extracellular space; perikaryon; terminal bouton growth hormone-releasing hormone activity growth hormone-releasing hormone receptor binding neuropeptide hormone activity peptide hormone receptor binding Homo sapiens 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Pharmaceutical Reference proteome Secreted Signal MPLWVFFFVI MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARLGRQVDSMWAEQKQMELESILVALLQKHSRNSQG |
chemical synaptic transmission inflammatory response neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration response to pain sensory perception of pain tachykinin receptor signaling pathway | axon; extracellular region; extracellular space; neuronal cell body; synapse | substance P receptor binding | Bos taurus | Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Neuropeptide Neurotransmitter Reference proteome Secreted Signal | MKILVAVAVI | MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK | chemical synaptic transmission inflammatory response neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration response to pain sensory perception of pain tachykinin receptor signaling pathway axon; extracellular region; extracellular space; neuronal cell body; synapse substance P receptor binding Bos taurus Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Neuropeptide Neurotransmitter Reference proteome Secreted Signal MKILVAVAVI MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK |
feeding behavior neuropeptide signaling pathway protein secretion | cytoplasm; extracellular region; extracellular space | G protein-coupled receptor binding hormone activity neuropeptide hormone activity neuropeptide Y receptor binding | Homo sapiens | 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Reference proteome Secreted Signal | MAAARLCLSL | MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL | feeding behavior neuropeptide signaling pathway protein secretion cytoplasm; extracellular region; extracellular space G protein-coupled receptor binding hormone activity neuropeptide hormone activity neuropeptide Y receptor binding Homo sapiens 3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Reference proteome Secreted Signal MAAARLCLSL MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL |
adult feeding behavior central nervous system neuron development cerebral cortex development chemical synaptic transmission feeding behavior G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger intestinal epithelial cell differentiation neuron projection development neuropeptide signaling pathway positive regulation of appetite regulation of blood pressure synaptic signaling via neuropeptide | extracellular region; extracellular space; GABA-ergic synapse; Golgi apparatus; neuronal dense core vesicle | calcium channel regulator activity G protein-coupled receptor activity neuropeptide hormone activity neuropeptide Y receptor binding signaling receptor binding | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Neuropeptide Phosphoprotein Reference proteome Secreted Signal | MLGNKRLGLS | MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW | adult feeding behavior central nervous system neuron development cerebral cortex development chemical synaptic transmission feeding behavior G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger intestinal epithelial cell differentiation neuron projection development neuropeptide signaling pathway positive regulation of appetite regulation of blood pressure synaptic signaling via neuropeptide extracellular region; extracellular space; GABA-ergic synapse; Golgi apparatus; neuronal dense core vesicle calcium channel regulator activity G protein-coupled receptor activity neuropeptide hormone activity neuropeptide Y receptor binding signaling receptor binding Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Neuropeptide Phosphoprotein Reference proteome Secreted Signal MLGNKRLGLS MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW |
estradiol secretion feeding behavior glucose homeostasis glucose import in response to insulin stimulus glucose metabolic process negative regulation of apoptotic process negative regulation of appetite negative regulation of lactation negative regulation of lipid catabolic process positive regulation of blood circulation positive regulation of cell maturation positive regulation of gene expression positive regulation of insulin secretion positive regulation of lactation positive regulation of mammary gland epithelial cell proliferation positive regulation of peptide hormone secretion positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein secretion positive regulation of Rho protein signal transduction protein secretion response to butyrate response to food response to glucose response to growth hormone response to heat response to L-arginine response to nutrient levels | extracellular space | hormone activity identical protein binding insulin receptor binding | Bos taurus | 3D-structure Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal | MALWTRLRPL | MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN | estradiol secretion feeding behavior glucose homeostasis glucose import in response to insulin stimulus glucose metabolic process negative regulation of apoptotic process negative regulation of appetite negative regulation of lactation negative regulation of lipid catabolic process positive regulation of blood circulation positive regulation of cell maturation positive regulation of gene expression positive regulation of insulin secretion positive regulation of lactation positive regulation of mammary gland epithelial cell proliferation positive regulation of peptide hormone secretion positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of protein secretion positive regulation of Rho protein signal transduction protein secretion response to butyrate response to food response to glucose response to growth hormone response to heat response to L-arginine response to nutrient levels extracellular space hormone activity identical protein binding insulin receptor binding Bos taurus 3D-structure Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal MALWTRLRPL MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN |
cellular response to glucose stimulus cellular response to oxygen-containing compound glucose homeostasis glucose metabolic process insulin receptor signaling pathway positive regulation of protein secretion receptor internalization response to cAMP response to cytokine response to organic substance response to peptide hormone | cytosol; extracellular space | hormone activity insulin receptor binding | Rattus norvegicus | Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal | MALWMRFLPL | MALWMRFLPLLALLVLWEPKPAQAFVKQHLCGPHLVEALYLVCGERGFFYTPKSRREVEDPQVPQLELGGGPEAGDLQTLALEVARQKRGIVDQCCTSICSLYQLENYCN | cellular response to glucose stimulus cellular response to oxygen-containing compound glucose homeostasis glucose metabolic process insulin receptor signaling pathway positive regulation of protein secretion receptor internalization response to cAMP response to cytokine response to organic substance response to peptide hormone cytosol; extracellular space hormone activity insulin receptor binding Rattus norvegicus Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal MALWMRFLPL MALWMRFLPLLALLVLWEPKPAQAFVKQHLCGPHLVEALYLVCGERGFFYTPKSRREVEDPQVPQLELGGGPEAGDLQTLALEVARQKRGIVDQCCTSICSLYQLENYCN |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway developmental growth mammary gland morphogenesis negative regulation of apoptotic process nipple development prostate gland growth regulation of apoptotic process regulation of body fluid levels regulation of cell population proliferation regulation of nitric oxide mediated signal transduction spermatogenesis | extracellular region | hormone activity signaling receptor binding | Rattus norvegicus | Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MSSRLLLQLL | MSSRLLLQLLGFWLFLSQPCRARVSEEWMDQVIQVCGRGYARAWIEVCGASVGRLALSQEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSDAQSRKKRQSGALLSEQCCHIGCTRRSIAKLC | adenylate cyclase-modulating G protein-coupled receptor signaling pathway developmental growth mammary gland morphogenesis negative regulation of apoptotic process nipple development prostate gland growth regulation of apoptotic process regulation of body fluid levels regulation of cell population proliferation regulation of nitric oxide mediated signal transduction spermatogenesis extracellular region hormone activity signaling receptor binding Rattus norvegicus Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal MSSRLLLQLL MSSRLLLQLLGFWLFLSQPCRARVSEEWMDQVIQVCGRGYARAWIEVCGASVGRLALSQEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSDAQSRKKRQSGALLSEQCCHIGCTRRSIAKLC |
blastocyst growth flagellated sperm motility oocyte maturation positive regulation of acrosome reaction positive regulation of epithelial cell proliferation positive regulation of glucose import | extracellular region | hormone activity | Sus scrofa | Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MPRLFSYLLG | MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAETMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC | blastocyst growth flagellated sperm motility oocyte maturation positive regulation of acrosome reaction positive regulation of epithelial cell proliferation positive regulation of glucose import extracellular region hormone activity Sus scrofa Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal MPRLFSYLLG MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAETMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC |
G protein-coupled receptor signaling pathway response to food signal transduction | extracellular region; extracellular space | hormone activity | Homo sapiens | 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation | MQRLCVYVLI | MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN | G protein-coupled receptor signaling pathway response to food signal transduction extracellular region; extracellular space hormone activity Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation MQRLCVYVLI MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN |
axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regulation of cell population proliferation positive regulation of glutamate secretion positive regulation of mitochondrial depolarization positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein-containing complex assembly protein kinase C-activating G protein-coupled receptor signaling pathway release of cytochrome c from mitochondria synaptic signaling via neuropeptide visual learning | axon; axon hillock; axon initial segment; dendrite; extracellular region; extracellular space; GABA-ergic synapse; neuronal cell body; perikaryon; terminal bouton | hormone activity neuropeptide hormone activity peptide hormone receptor binding receptor ligand activity | Rattus norvegicus | Amidation Cleavage on pair of basic residues Hormone Reference proteome Secreted Signal Sulfation | MKCGVCLCVV | MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS | axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regulation of cell population proliferation positive regulation of glutamate secretion positive regulation of mitochondrial depolarization positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein-containing complex assembly protein kinase C-activating G protein-coupled receptor signaling pathway release of cytochrome c from mitochondria synaptic signaling via neuropeptide visual learning axon; axon hillock; axon initial segment; dendrite; extracellular region; extracellular space; GABA-ergic synapse; neuronal cell body; perikaryon; terminal bouton hormone activity neuropeptide hormone activity peptide hormone receptor binding receptor ligand activity Rattus norvegicus Amidation Cleavage on pair of basic residues Hormone Reference proteome Secreted Signal Sulfation MKCGVCLCVV MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS |
neuropeptide signaling pathway | extracellular region | hormone activity | Aplysia californica | Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Secreted Signal | MKRPNNRPTN | MKRPNNRPTNTMSLILCLTLSSLCVSSQSASVHGKNFATNRAVKSSSPFVVLSPDDNVVSMSGENGYRSALREAFDKSSRDYDDNGEDVFSNEKRRLRFHKRRLRFDRRDQDEGNFRRFPTNAVSMSADENSPFDLSNEDGAVYQRDLRAPRLRFYSLRKRAAGGMEQSEGQNPETESHSRRKRSVLTPSLSSLGESLESGISKRISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEKGKRSSGVSLLTSNKDEEQRELLKAISNLLD | neuropeptide signaling pathway extracellular region hormone activity Aplysia californica Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Secreted Signal MKRPNNRPTN MKRPNNRPTNTMSLILCLTLSSLCVSSQSASVHGKNFATNRAVKSSSPFVVLSPDDNVVSMSGENGYRSALREAFDKSSRDYDDNGEDVFSNEKRRLRFHKRRLRFDRRDQDEGNFRRFPTNAVSMSADENSPFDLSNEDGAVYQRDLRAPRLRFYSLRKRAAGGMEQSEGQNPETESHSRRKRSVLTPSLSSLGESLESGISKRISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEKGKRSSGVSLLTSNKDEEQRELLKAISNLLD |
apoptotic process cell-cell signaling defense response to Gram-positive bacterium humoral immune response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of glial cell proliferation positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of type II interferon production response to hypoxia response to lipopolysaccharide response to nutrient response to xenobiotic stimulus signal transduction | extracellular space; plasma membrane | cytokine activity signaling receptor binding tumor necrosis factor receptor binding | Homo sapiens | 3D-structure Cytokine Direct protein sequencing Glycoprotein Membrane Reference proteome Secreted Signal | MTPPERLFLP | MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL | apoptotic process cell-cell signaling defense response to Gram-positive bacterium humoral immune response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of glial cell proliferation positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of type II interferon production response to hypoxia response to lipopolysaccharide response to nutrient response to xenobiotic stimulus signal transduction extracellular space; plasma membrane cytokine activity signaling receptor binding tumor necrosis factor receptor binding Homo sapiens 3D-structure Cytokine Direct protein sequencing Glycoprotein Membrane Reference proteome Secreted Signal MTPPERLFLP MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL |
killing of cells of another organism | extracellular region; membrane; other organism cell membrane | toxin activity | Naja kaouthia | 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Membrane Secreted Target cell membrane Target membrane Toxin | LKCNKLIPLA | LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDVCPKNSLLVKYVCCNTDRCN | killing of cells of another organism extracellular region; membrane; other organism cell membrane toxin activity Naja kaouthia 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Membrane Secreted Target cell membrane Target membrane Toxin LKCNKLIPLA LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDVCPKNSLLVKYVCCNTDRCN |
killing of cells of another organism modulation of process of another organism | extracellular region; membrane; other organism cell membrane | toxin activity | Naja kaouthia | 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Membrane Secreted Target cell membrane Target membrane Toxin | LKCNKLIPLA | LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDACPKNSLLVKYVCCNTDRCN | killing of cells of another organism modulation of process of another organism extracellular region; membrane; other organism cell membrane toxin activity Naja kaouthia 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Membrane Secreted Target cell membrane Target membrane Toxin LKCNKLIPLA LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDACPKNSLLVKYVCCNTDRCN |
defense response | extracellular region | sodium channel inhibitor activity toxin activity | Androctonus australis | 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin | MNYLVMISLA | MNYLVMISLALLFVTGVESVKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVRTKGPGRCHGR | defense response extracellular region sodium channel inhibitor activity toxin activity Androctonus australis 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin MNYLVMISLA MNYLVMISLALLFVTGVESVKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVRTKGPGRCHGR |
defense response | extracellular region | sodium channel inhibitor activity toxin activity | Buthus occitanus tunetanus | Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin | LVMAGVESVK | LVMAGVESVKDGYIVDDRNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKVPDHVRTKGPGRCN | defense response extracellular region sodium channel inhibitor activity toxin activity Buthus occitanus tunetanus Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin LVMAGVESVK LVMAGVESVKDGYIVDDRNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKVPDHVRTKGPGRCN |
defense response | extracellular region | sodium channel inhibitor activity toxin activity | Leiurus quinquestriatus quinquestriatus | 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin | GVRDAYIADD | GVRDAYIADDKNCVYTCGSNSYCNTECTKNGAESGYCQWLGKYGNACWCIKLPDKVPIRIPGKCR | defense response extracellular region sodium channel inhibitor activity toxin activity Leiurus quinquestriatus quinquestriatus 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin GVRDAYIADD GVRDAYIADDKNCVYTCGSNSYCNTECTKNGAESGYCQWLGKYGNACWCIKLPDKVPIRIPGKCR |
defense response | extracellular region | sodium channel inhibitor activity toxin activity | Centruroides sculpturatus | 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin | MNSLLIITAC | MNSLLIITACFALVGTVWAKEGYLVKKSDGCKYDCFWLGKNEHCDTECKAKNQGGSYGYCYAFACWCEGLPESTPTYPLPNKSCGKK | defense response extracellular region sodium channel inhibitor activity toxin activity Centruroides sculpturatus 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin MNSLLIITAC MNSLLIITACFALVGTVWAKEGYLVKKSDGCKYDCFWLGKNEHCDTECKAKNQGGSYGYCYAFACWCEGLPESTPTYPLPNKSCGKK |
modulation of process of another organism negative regulation of inward rectifier potassium channel activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transporter activity | extracellular region | inward rectifier potassium channel inhibitor activity potassium channel inhibitor activity toxin activity | Apis mellifera | 3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin Voltage-gated potassium channel impairing toxin | MISMLRCIYL | MISMLRCIYLFLSVILITSYFVTPVMPCNCKAPETALCARRCQQHG | modulation of process of another organism negative regulation of inward rectifier potassium channel activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transporter activity extracellular region inward rectifier potassium channel inhibitor activity potassium channel inhibitor activity toxin activity Apis mellifera 3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin Voltage-gated potassium channel impairing toxin MISMLRCIYL MISMLRCIYLFLSVILITSYFVTPVMPCNCKAPETALCARRCQQHG |
killing of cells of another organism localization monoatomic ion transport | extracellular region; other organism cell membrane; pore complex | lipid binding molecular function inhibitor activity porin activity protein kinase inhibitor activity toxin activity | Apis mellifera | 3D-structure Allergen Amidation Antimicrobial Cytolysis Direct protein sequencing Formylation Hemolysis Ion transport Membrane Pharmaceutical Porin Reference proteome Secreted Signal Target cell membrane Target membrane Toxin Transmembrane Transport | MKFLVNVALV | MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG | killing of cells of another organism localization monoatomic ion transport extracellular region; other organism cell membrane; pore complex lipid binding molecular function inhibitor activity porin activity protein kinase inhibitor activity toxin activity Apis mellifera 3D-structure Allergen Amidation Antimicrobial Cytolysis Direct protein sequencing Formylation Hemolysis Ion transport Membrane Pharmaceutical Porin Reference proteome Secreted Signal Target cell membrane Target membrane Toxin Transmembrane Transport MKFLVNVALV MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG |
regulation of signal transduction | extracellular region; nematocyst | sodium channel regulator activity toxin activity | Anthopleura xanthogrammica | 3D-structure Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin | GVPCLCDSDG | GVPCLCDSDGPRPRGNTLSGILWFYPSGCPSGWHNCKAHGPNIGWCCKK | regulation of signal transduction extracellular region; nematocyst sodium channel regulator activity toxin activity Anthopleura xanthogrammica 3D-structure Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin GVPCLCDSDG GVPCLCDSDGPRPRGNTLSGILWFYPSGCPSGWHNCKAHGPNIGWCCKK |
localization positive regulation of tyrosine phosphorylation of STAT protein | catalytic complex; extracellular space; periplasmic space | galactose binding glycosyltransferase activity lipid binding nucleotidyltransferase activity toxin activity | Vibrio cholerae serotype O1 | 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Glycosyltransferase NAD Nucleotidyltransferase Reference proteome Signal Toxin Transferase Virulence | MVKIIFVFFI | MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL | localization positive regulation of tyrosine phosphorylation of STAT protein catalytic complex; extracellular space; periplasmic space galactose binding glycosyltransferase activity lipid binding nucleotidyltransferase activity toxin activity Vibrio cholerae serotype O1 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Glycosyltransferase NAD Nucleotidyltransferase Reference proteome Signal Toxin Transferase Virulence MVKIIFVFFI MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL |
positive regulation of tyrosine phosphorylation of STAT protein | catalytic complex; extracellular region; host cell plasma membrane; membrane; periplasmic space | galactose binding host cell surface binding toxin activity | Vibrio cholerae serotype O1 | 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Host cell membrane Host membrane Membrane Reference proteome Secreted Signal Toxin Virulence | MIKLKFGVFF | MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN | positive regulation of tyrosine phosphorylation of STAT protein catalytic complex; extracellular region; host cell plasma membrane; membrane; periplasmic space galactose binding host cell surface binding toxin activity Vibrio cholerae serotype O1 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Host cell membrane Host membrane Membrane Reference proteome Secreted Signal Toxin Virulence MIKLKFGVFF MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN |
adaptive immune response B cell differentiation B cell proliferation cellular response to virus cytokine-mediated signaling pathway defense response to virus humoral immune response natural killer cell activation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein response to exogenous dsRNA T cell activation involved in immune response type I interferon-mediated signaling pathway | extracellular region; extracellular space | cytokine activity type I interferon receptor binding | Homo sapiens | 3D-structure Antiviral defense Cytokine Direct protein sequencing Disulfide bond Reference proteome Secreted Signal | MASPFALLMV | MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE | adaptive immune response B cell differentiation B cell proliferation cellular response to virus cytokine-mediated signaling pathway defense response to virus humoral immune response natural killer cell activation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein response to exogenous dsRNA T cell activation involved in immune response type I interferon-mediated signaling pathway extracellular region; extracellular space cytokine activity type I interferon receptor binding Homo sapiens 3D-structure Antiviral defense Cytokine Direct protein sequencing Disulfide bond Reference proteome Secreted Signal MASPFALLMV MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE |
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