Biological Process
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Cellular Component
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Molecular Function
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871
Organism
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Keywords
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Sequence 10
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10
Sequence
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1.02k
Combined
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136
3.91k
methionyl-tRNA aminoacylation
cytosol; membrane
ATP binding methionine-tRNA ligase activity protein homodimerization activity tRNA binding zinc ion binding
Escherichia coli
3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Metal-binding Nucleotide-binding Protein biosynthesis Reference proteome RNA-binding tRNA-binding Zinc
MTQVAKKILV
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPSN...
methionyl-tRNA aminoacylation cytosol; membrane ATP binding methionine-tRNA ligase activity protein homodimerization activity tRNA binding zinc ion binding Escherichia coli 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Metal-binding Nucleotide-binding Protein biosynthesis...
glutaminyl-tRNA aminoacylation glutamyl-tRNA aminoacylation
cytosol
ATP binding glutamine-tRNA ligase activity
Escherichia coli
3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Protein biosynthesis Reference proteome
MSEAEARPTN
MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYKGQCNLRFDDTNPVKEDIEYVESIKNDVEWLGFHWSGNVRYSSDYFDQLHAYAIELINKGLAYVDELTPEQIREYRGTLTQPGKNSPYRDRSVEENLALFEKMRAGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQD...
glutaminyl-tRNA aminoacylation glutamyl-tRNA aminoacylation cytosol ATP binding glutamine-tRNA ligase activity Escherichia coli 3D-structure Aminoacyl-tRNA synthetase ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Protein biosynthesis Reference proteome MSEAEARPTN MSEAEARPTNFIRQIIDEDLASGKHTTV...
asparagine biosynthetic process DNA damage response L-asparagine biosynthetic process
cytosol
aspartate-ammonia ligase activity ATP binding identical protein binding protein homodimerization activity
Escherichia coli
3D-structure Amino-acid biosynthesis Asparagine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Ligase Nucleotide-binding Reference proteome
MKTAYIAKQR
MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPA...
asparagine biosynthetic process DNA damage response L-asparagine biosynthetic process cytosol aspartate-ammonia ligase activity ATP binding identical protein binding protein homodimerization activity Escherichia coli 3D-structure Amino-acid biosynthesis Asparagine biosynthesis ATP-binding Cytoplasm Direct protein seque...
acute-phase response arginine biosynthetic process argininosuccinate metabolic process aspartate metabolic process cellular response to amine stimulus cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to dexamethasone stimulus cellular response to glu...
cell body fiber; cytoplasm; cytosol; extracellular exosome; mitochondrial outer membrane; nucleoplasm; perikaryon
amino acid binding argininosuccinate synthase activity ATP binding identical protein binding RNA binding toxic substance binding
Homo sapiens
3D-structure Acetylation Amino-acid biosynthesis Arginine biosynthesis ATP-binding Cytoplasm Direct protein sequencing Disease variant Ligase Nucleotide-binding Phosphoprotein Reference proteome Urea cycle
MSSKGSVVLA
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAEL...
acute-phase response arginine biosynthetic process argininosuccinate metabolic process aspartate metabolic process cellular response to amine stimulus cellular response to amino acid stimulus cellular response to ammonium ion cellular response to cAMP cellular response to dexamethasone stimulus cellular response to glu...
antiviral innate immune response cellular response to interferon-alpha cellular response to interferon-beta cellular response to virus defense response to bacterium defense response to virus glucose homeostasis glucose metabolic process interleukin-27-mediated signaling pathway negative regulation of chemokine (C-X-C m...
cytoplasm; cytosol; endoplasmic reticulum; extracellular region; membrane; mitochondrion; nucleoplasm; nucleus; ribosome
2'-5'-oligoadenylate synthetase activity ATP binding double-stranded RNA binding metal ion binding
Homo sapiens
3D-structure Alternative splicing Antiviral defense ATP-binding Cytoplasm Disease variant Endoplasmic reticulum Host-virus interaction Immunity Innate immunity Lipoprotein Magnesium Metal-binding Microsome Mitochondrion Nucleotide-binding Nucleotidyltransferase Nucleus Prenylation Reference proteome RNA-binding Secrete...
MMDLRNTPAK
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVLPAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILDPADPTGNLGGGDPKGWRQLA...
antiviral innate immune response cellular response to interferon-alpha cellular response to interferon-beta cellular response to virus defense response to bacterium defense response to virus glucose homeostasis glucose metabolic process interleukin-27-mediated signaling pathway negative regulation of chemokine (C-X-C m...
negative regulation of platelet aggregation negative regulation of serine-type endopeptidase activity negative regulation of thrombin-activated receptor signaling pathway trypsinogen activation
extracellular space; serine protease inhibitor complex
calcium ion binding molecular function inhibitor activity potassium channel inhibitor activity protease binding serine-type endopeptidase inhibitor activity sulfate binding zymogen binding
Bos taurus
3D-structure Direct protein sequencing Disulfide bond Pharmaceutical Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal
MKMSRLCLSV
MKMSRLCLSVALLVLLGTLAASTPGCDTSNQAKAQRPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGAIGPWENL
negative regulation of platelet aggregation negative regulation of serine-type endopeptidase activity negative regulation of thrombin-activated receptor signaling pathway trypsinogen activation extracellular space; serine protease inhibitor complex calcium ion binding molecular function inhibitor activity potassium cha...
cellular response to peptide hormone stimulus negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction positive regulation of cytosolic calcium ion concentration positive ...
extracellular exosome
endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity
Homo sapiens
3D-structure Direct protein sequencing Disease variant Disulfide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal
MKVTGIFLLS
MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC
cellular response to peptide hormone stimulus negative regulation of calcium ion import negative regulation of nitric oxide mediated signal transduction negative regulation of peptidyl-tyrosine phosphorylation nitric oxide mediated signal transduction positive regulation of cytosolic calcium ion concentration positive ...
response to steroid hormone
endoplasmic reticulum; extracellular space; protein-containing complex
carbohydrate binding IgE binding IgG binding serine-type endopeptidase inhibitor activity
Gallus gallus
Allergen Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Reference proteome Repeat Secreted Serine protease inhibitor Signal
MAMAGVFVLF
MAMAGVFVLFSFVLCGFLPDAAFGAEVDCSRFPNATDKEGKDVLVCNKDLRPICGTDGVTYTNDCLLCAYSIEFGTNISKEHDGECKETVPMNCSSYANTTSEDGKVMVLCNRAFNPVCGTDGVTYDNECLLCAHKVEQGASVDKRHDGGCRKELAAVSVDCSEYPKPDCTAEDRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC
response to steroid hormone endoplasmic reticulum; extracellular space; protein-containing complex carbohydrate binding IgE binding IgG binding serine-type endopeptidase inhibitor activity Gallus gallus Allergen Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Reference proteome Repeat Secreted ...
blood coagulation regulation of blood coagulation
blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane
heparin binding identical protein binding protease binding serine-type endopeptidase inhibitor activity
Homo sapiens
3D-structure Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Heparin-binding Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal Thrombophilia
MYSNVIGTVT
MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKP...
blood coagulation regulation of blood coagulation blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane heparin binding identical protein binding protease binding serine-type endopeptidase inhibitor a...
acute-phase response blood coagulation
collagen-containing extracellular matrix; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; intrac...
identical protein binding protease binding serine-type endopeptidase inhibitor activity
Homo sapiens
3D-structure Acute phase Alternative splicing Blood coagulation Direct protein sequencing Endoplasmic reticulum Extracellular matrix Glycoprotein Hemostasis Phosphoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal
MPSSVSWGIL
MPSSVSWGILLLAGLCCLVPVSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGT...
acute-phase response blood coagulation collagen-containing extracellular matrix; COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich...
acute-phase response inflammatory response maintenance of gastrointestinal epithelium regulation of lipid metabolic process
azurophil granule lumen; blood microparticle; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; nucleus; platelet alpha granule lumen; secretory granule lumen
DNA binding serine-type endopeptidase inhibitor activity
Homo sapiens
3D-structure Acute phase Alternative splicing Direct protein sequencing Disease variant Glycoprotein Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal
MERMLPLLAL
MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISR...
acute-phase response inflammatory response maintenance of gastrointestinal epithelium regulation of lipid metabolic process azurophil granule lumen; blood microparticle; collagen-containing extracellular matrix; extracellular exosome; extracellular region; extracellular space; nucleus; platelet alpha granule lumen; sec...
embryo development ending in birth or egg hatching intracellular amino acid homeostasis monoatomic ion homeostasis monoatomic ion transport response to corticosterone response to estrogen response to progesterone response to steroid hormone
cytosol; early endosome lumen; endoplasmic reticulum; extracellular region; extracellular space; intracellular membrane-bounded organelle; phagocytic vesicle; phagolysosome; vesicle
calcium ion binding protease binding
Gallus gallus
3D-structure Acetylation Allergen Calcium Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Phosphoprotein Reference proteome Secreted Signal
MGSIGAASME
MGSIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAE...
embryo development ending in birth or egg hatching intracellular amino acid homeostasis monoatomic ion homeostasis monoatomic ion transport response to corticosterone response to estrogen response to progesterone response to steroid hormone cytosol; early endosome lumen; endoplasmic reticulum; extracellular region; ext...
regulation of blood pressure vasodilation
extracellular region
hormone activity metalloendopeptidase inhibitor activity toxin activity
Gloydius blomhoffii
3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hypotensive agent Metalloenzyme inhibitor Metalloprotease inhibitor Protease inhibitor Pyrrolidone carboxylic acid Repeat Secreted Signal Toxin Vasoactive Vasodilator
MFVSRLAASG
MFVSRLAASGLLLLALMALSLDGKPVQQWSQGRPPGPPIPRLVVQQWSQGLPPGPPIPRLVVQQWSQGLPPGPPIPPLVVQQWSQGLPPRPKIPPLVVQQWSQGLPPRPKIPPLVVQKWDPPPVSPPLLLQPHESPAGGTTALREELSLGPEAASGPAAAGADGGRSGSKAPAALHRLSKSKGASATSASASRPMRDLRTDGKQARQNWARMVNPDHHAVGGCCCGGGGGGARRLKGLVKKGVAKGCFGLKLDRIGTMSGLGC
regulation of blood pressure vasodilation extracellular region hormone activity metalloendopeptidase inhibitor activity toxin activity Gloydius blomhoffii 3D-structure Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hypotensive agent Metalloenzyme inhibitor Metalloprotease inhibitor Proteas...
cartilage development cellular response to UV-A connective tissue replacement involved in inflammatory response wound healing negative regulation of apoptotic process negative regulation of catalytic activity negative regulation of endopeptidase activity negative regulation of membrane protein ectodomain proteolysis ne...
basement membrane; endoplasmic reticulum lumen; extracellular exosome; extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen
cytokine activity growth factor activity metalloendopeptidase inhibitor activity peptidase inhibitor activity protease binding zinc ion binding
Homo sapiens
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Growth factor Metal-binding Metalloenzyme inhibitor Metalloprotease inhibitor Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Zinc
MAPFEPLASG
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
cartilage development cellular response to UV-A connective tissue replacement involved in inflammatory response wound healing negative regulation of apoptotic process negative regulation of catalytic activity negative regulation of endopeptidase activity negative regulation of membrane protein ectodomain proteolysis ne...
defense response negative regulation of blood vessel remodeling negative regulation of collagen catabolic process negative regulation of elastin catabolic process negative regulation of extracellular matrix disassembly negative regulation of peptidase activity negative regulation of proteolysis regulation of tissue rem...
cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; Golgi apparatus; plasma membrane; tertiary granule lumen; vesicle
amyloid-beta binding cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity identical protein binding peptidase inhibitor activity protease binding
Homo sapiens
3D-structure Age-related macular degeneration Amyloid Amyloidosis Direct protein sequencing Disease variant Disulfide bond Glycoprotein Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor
MAGPLRAPLL
MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA
defense response negative regulation of blood vessel remodeling negative regulation of collagen catabolic process negative regulation of elastin catabolic process negative regulation of extracellular matrix disassembly negative regulation of peptidase activity negative regulation of proteolysis regulation of tissue rem...
detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of proteolysis
cytoplasm; extracellular exosome; extracellular space; vesicle
cysteine-type endopeptidase inhibitor activity
Homo sapiens
Direct protein sequencing Disulfide bond Phosphoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor
MARPLCTLLL
MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWEDRMSLVNSRCQEA
detection of chemical stimulus involved in sensory perception of bitter taste negative regulation of proteolysis cytoplasm; extracellular exosome; extracellular space; vesicle cysteine-type endopeptidase inhibitor activity Homo sapiens Direct protein sequencing Disulfide bond Phosphoprotein Protease inhibitor Reference...
detection of chemical stimulus involved in sensory perception of bitter taste
cytoplasm; extracellular space; vesicle
cysteine-type endopeptidase inhibitor activity
Homo sapiens
Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor
MAQYLSTLLL
MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES
detection of chemical stimulus involved in sensory perception of bitter taste cytoplasm; extracellular space; vesicle cysteine-type endopeptidase inhibitor activity Homo sapiens Direct protein sequencing Disulfide bond Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor MAQYLSTLLL MAQYLSTLLLL...
cell-cell adhesion keratinocyte differentiation negative regulation of peptidase activity negative regulation of proteolysis peptide cross-linking
cornified envelope; cytoplasm; cytosol; extracellular space; nucleoplasm; peptidase inhibitor complex
cysteine-type endopeptidase inhibitor activity protease binding
Homo sapiens
3D-structure Acetylation Cell adhesion Cytoplasm Direct protein sequencing Ichthyosis Protease inhibitor Reference proteome Thiol protease inhibitor
MIPGGLSEAK
MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF
cell-cell adhesion keratinocyte differentiation negative regulation of peptidase activity negative regulation of proteolysis peptide cross-linking cornified envelope; cytoplasm; cytosol; extracellular space; nucleoplasm; peptidase inhibitor complex cysteine-type endopeptidase inhibitor activity protease binding Homo sa...
blood coagulation inflammatory response negative regulation of blood coagulation negative regulation of cell adhesion negative regulation of proteolysis positive regulation of apoptotic process positive regulation of cytosolic calcium ion concentration vasodilation
blood microparticle; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; plasma membrane; platelet alpha granule lumen
cysteine-type endopeptidase inhibitor activity heparin binding hormone activity signaling receptor binding zinc ion binding
Homo sapiens
3D-structure Alternative splicing Blood coagulation Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Phosphoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator
MKLITILFLC
MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFRITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVAGKKYFID...
blood coagulation inflammatory response negative regulation of blood coagulation negative regulation of cell adhesion negative regulation of proteolysis positive regulation of apoptotic process positive regulation of cytosolic calcium ion concentration vasodilation blood microparticle; collagen-containing extracellular...
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation
extracellular region
cysteine-type endopeptidase inhibitor activity
Bos taurus
Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Inflammatory response Phosphoprotein Protease inhibitor Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator
MKLITILFLC
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGECTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQRQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPVKDFVQPPTRLCAGCPKPIPVDSPDLEEPLSHSIAKLNAEHDGAFYFKIDTVKKATVQVVAGLKYSIVF...
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Bos taurus Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycopro...
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation
extracellular region
cysteine-type endopeptidase inhibitor activity
Bos taurus
Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycoprotein Hemostasis Hydroxylation Inflammatory response Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator
MKLITILFLC
MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDTVKKATVQVVGGLKYSIVFIA...
blood coagulation inflammatory response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Bos taurus Alternative splicing Blood coagulation Direct protein sequencing Disulfide bond Glycopro...
acute-phase response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation
extracellular region
cysteine-type endopeptidase inhibitor activity
Rattus norvegicus
Acute phase Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Thiol protease inhibitor Vasoactive Vasodilator
MKLITILLLC
MKLITILLLCSRLLPSLAQEEGAQELNCNDETVFQAVDTALKKYNAELESGNQFVLYRVTEGTKKDGAETLYSFKYQIKEGNCSVQSGLTWQDCDFKDAEEAATGECTTTLGKKENKFSVATQICNITPGKGPKKTEEDLCVGCFQPIPMDSSDLKPVLKHAVEHFNNNTKHTHLFALREVKSAHSQVVAGMNYKIIYSIVQTNCSKEDFPSLREDCVPLPYGDHGECTGHTHVDIHNTIAGFSQSCDLYPGDDLFELLPKNCRGCPREIPVDSPELKEALGHSIAQLNAQHNHIFYFKIDTVKKATSQVVAGVIYVIEF...
acute-phase response negative regulation of blood coagulation positive regulation of cytosolic calcium ion concentration vasodilation extracellular region cysteine-type endopeptidase inhibitor activity Rattus norvegicus Acute phase Direct protein sequencing Disulfide bond Glycoprotein Protease inhibitor Pyrrolidone car...
negative regulation of serine-type peptidase activity
extracellular space
serine-type endopeptidase inhibitor activity
Hirudo medicinalis
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Pharmaceutical Protease inhibitor Secreted Serine protease inhibitor Sulfation
VVYTDCTESG
VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
negative regulation of serine-type peptidase activity extracellular space serine-type endopeptidase inhibitor activity Hirudo medicinalis 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Pharmaceutical Protease inhibitor Secreted Serine protease inhibitor Sulfation VVYTDCTESG VVYTDCTESGQNLCLCEGSNVCGQG...
negative regulation of endopeptidase activity protein catabolic process in the vacuole
cytoplasm; nucleus; protein-containing complex; vacuole
aspartic-type endopeptidase inhibitor activity endopeptidase inhibitor activity protease binding
Saccharomyces cerevisiae
3D-structure Acetylation Aspartic protease inhibitor Direct protein sequencing Protease inhibitor Reference proteome
MNTDQQKVSE
MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE
negative regulation of endopeptidase activity protein catabolic process in the vacuole cytoplasm; nucleus; protein-containing complex; vacuole aspartic-type endopeptidase inhibitor activity endopeptidase inhibitor activity protease binding Saccharomyces cerevisiae 3D-structure Acetylation Aspartic protease inhibitor D...
erythrocyte differentiation heme biosynthetic process negative regulation of endothelial cell proliferation negative regulation of hydrolase activity protein homotetramerization
cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion; protein-containing complex
angiostatin binding ATPase binding ATPase inhibitor activity calmodulin binding identical protein binding protein homodimerization activity structural molecule activity
Bos taurus
3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide
MAATALAART
MAATALAARTRQAVWSVWAMQGRGFGSESGDNVRSSAGAVRDAGGAFGKREQAEEERYFRARAKEQLAALKKHHENEISHHAKEIERLQKEIERHKQSIKKLKQSEDDD
erythrocyte differentiation heme biosynthetic process negative regulation of endothelial cell proliferation negative regulation of hydrolase activity protein homotetramerization cell surface; mitochondrial proton-transporting ATP synthase complex; mitochondrion; protein-containing complex angiostatin binding ATPase bin...
negative regulation of ATP-dependent activity
mitochondrion
ATPase inhibitor activity enzyme inhibitor activity molecular function inhibitor activity
Saccharomyces cerevisiae
3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide
MLPRSALARS
MLPRSALARSLQLQRGVAARFYSEGSTGTPRGSGSEDSFVKRERATEDFFVRQREKEQLRHLKEQLEKQRKKIDSLENKIDSMTK
negative regulation of ATP-dependent activity mitochondrion ATPase inhibitor activity enzyme inhibitor activity molecular function inhibitor activity Saccharomyces cerevisiae 3D-structure Coiled coil Direct protein sequencing Mitochondrion Reference proteome Transit peptide MLPRSALARS MLPRSALARSLQLQRGVAARFYSEGSTGTPRGS...
MAPK cascade myoblast differentiation positive regulation of endothelial cell proliferation Ras protein signal transduction
cytosol; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; Golgi membrane; membrane; plasma membrane; tertiary granule membrane
G protein activity GDP binding GTP binding GTPase activity protein-containing complex binding
Homo sapiens
3D-structure Acetylation Cell membrane Disease variant Glycoprotein Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Proto-oncogene Reference proteome Ubl conjugation
MTEYKLVVVG
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
MAPK cascade myoblast differentiation positive regulation of endothelial cell proliferation Ras protein signal transduction cytosol; endoplasmic reticulum membrane; extracellular exosome; Golgi apparatus; Golgi membrane; membrane; plasma membrane; tertiary granule membrane G protein activity GDP binding GTP binding GTP...
actin cytoskeleton organization epithelial tube branching involved in lung morphogenesis forebrain astrocyte development gene expression glial cell proliferation homeostasis of number of cells within a tissue MAPK cascade negative regulation of epithelial cell differentiation negative regulation of neuron apoptotic pro...
cytoplasm; cytoplasmic side of plasma membrane; cytosol; endoplasmic reticulum membrane; focal adhesion; Golgi membrane; membrane; mitochondrial outer membrane; plasma membrane
G protein activity GDP binding GTP binding GTPase activity identical protein binding protein-containing complex binding protein-membrane adaptor activity
Homo sapiens
3D-structure Acetylation Alternative splicing Cardiomyopathy Cell membrane Cytoplasm Deafness Direct protein sequencing Disease variant Ectodermal dysplasia Glycoprotein GTP-binding Hydrolase Intellectual disability Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Proto-oncogene...
MTEYKLVVVG
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
actin cytoskeleton organization epithelial tube branching involved in lung morphogenesis forebrain astrocyte development gene expression glial cell proliferation homeostasis of number of cells within a tissue MAPK cascade negative regulation of epithelial cell differentiation negative regulation of neuron apoptotic pro...
adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase activity protein localization to bud neck
cell periphery; cytoplasm; nucleus; plasma membrane
G protein activity GDP binding GTP binding GTPase activity
Saccharomyces cerevisiae
Cell membrane GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Prenylation Reference proteome
MQGNKSTIRE
MQGNKSTIREYKIVVVGGGGVGKSALTIQFIQSYFVDEYDPTIEDSYRKQVVIDDKVSILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRNSFDELLSYYQQIQRVKDSDYIPVVVVGNKLDLENERQVSYEDGLRLAKQLNAPFLETSAKQAINVDEAFYSLIRLVRDDGGKYNSMNRQLDNTNEIRDSELTSSATADREKKNNGSYVLDNSLTNAGTGSSSKSAVNHNGETTKRTDEKNYVNQNNNNEGNTKYSSNGNGNRSDISRGNQNNALNSRSKQSAEPQKNSSANARKESSGGCCIIC
adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of adenylate cyclase activity protein localization to bud neck cell periphery; cytoplasm; nucleus; plasma membrane G protein activity GDP binding GTP binding GTPase activity Saccharomyces cerevisiae Cell membrane GTP-binding ...
ascospore formation cytoplasm to vacuole transport by the Cvt pathway macroautophagy positive regulation of pseudohyphal growth positive regulation of transcription by galactose protein localization to bud neck regulation of cytoplasmic mRNA processing body assembly regulation of protein localization signal transductio...
cell periphery; endoplasmic reticulum membrane; mitochondrion; nucleus; plasma membrane
G protein activity GDP binding GTP binding GTPase activity
Saccharomyces cerevisiae
Cell membrane Direct protein sequencing GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Reference proteome Ubl conjugation
MPLNKSNIRE
MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVVVGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNKTLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKTGLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQAAPGGNTSEASKSGSGGCCI...
ascospore formation cytoplasm to vacuole transport by the Cvt pathway macroautophagy positive regulation of pseudohyphal growth positive regulation of transcription by galactose protein localization to bud neck regulation of cytoplasmic mRNA processing body assembly regulation of protein localization signal transductio...
autophagosome assembly COPII-coated vesicle budding cytoplasm to vacuole transport by the Cvt pathway early endosome to Golgi transport endocytic recycling endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle budding Golgi vesicle docking intracellular protein transport macroautophagy pre-mRNA catabo...
cis-Golgi network; cytoplasmic vesicle; cytosol; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; Golgi stack; mitochondrion; phagophore assembly site; phagophore assembly site membrane
GTP binding GTPase activity SNARE binding
Saccharomyces cerevisiae
3D-structure Acetylation Autophagy Cytoplasm Direct protein sequencing Endoplasmic reticulum ER-Golgi transport Golgi apparatus GTP-binding Isopeptide bond Lipoprotein Membrane Nucleotide-binding Palmitate Phosphoprotein Prenylation Protein transport Reference proteome Transport Ubl conjugation
MNSEYDYLFK
MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQEIDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVEDAFLTMARQIKESMSQQNLNETTQKKEDKGNVNLKGQSLTNTGGGCC
autophagosome assembly COPII-coated vesicle budding cytoplasm to vacuole transport by the Cvt pathway early endosome to Golgi transport endocytic recycling endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle budding Golgi vesicle docking intracellular protein transport macroautophagy pre-mRNA catabo...
cell division G1/S transition of mitotic cell cycle negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II rRNA transcription
chromatin; cytoplasm; MBF transcription complex; nucleus; SBF transcription complex
DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding
Schizosaccharomyces pombe
ANK repeat Cell cycle Cell division Mitosis Nucleus Phosphoprotein Reference proteome Repeat
MASANFIRQF
MASANFIRQFELGNDSFSYQKRPEDEPSQPLSNRNINKLNDSSTLKDSSSRIFINSQVLRDGRPVELYAVECSGMKYMELSCGDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQPLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSPLRNHNFSNPSKSSKNGVHTINNMQSSPSPSSSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDLHPSSQLNDNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTS...
cell division G1/S transition of mitotic cell cycle negative regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II rRNA transcription chromatin; cytoplasm; MBF transcription ...
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation mammary gland alveolus development negative regulation of apoptotic process positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial ce...
basolateral plasma membrane; cell surface; cytoplasmic vesicle; extracellular space; perinuclear region of cytoplasm
epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity
Rattus norvegicus
Cell membrane Direct protein sequencing Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix
MVPAAGQLAL
MVPAAGQLALLALGILVAVCQALENSTSPLSDSPVAAAVVSHFNKCPDSHTQYCFHGTCRFLVQEEKPACVCHSGYVGVRCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTACCHSETVV
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation mammary gland alveolus development negative regulation of apoptotic process positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial ce...
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation intracellular signal transduction mammary gland alveolus development positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell prol...
basolateral plasma membrane; cell surface; clathrin-coated endocytic vesicle membrane; cytoplasmic vesicle; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; extracellular region; extracellular space; perinuclear region of cytoplasm; p...
epidermal growth factor receptor binding growth factor activity receptor ligand activity transmembrane receptor protein tyrosine kinase activator activity
Homo sapiens
3D-structure Alternative splicing Cell membrane Disulfide bond EGF-like domain Glycoprotein Growth factor Lipoprotein Membrane Mitogen Palmitate Reference proteome Secreted Signal Transmembrane Transmembrane helix
MVPSAGQLAL
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
angiogenesis epidermal growth factor receptor signaling pathway ERBB2-EGFR signaling pathway hepatocyte proliferation intracellular signal transduction mammary gland alveolus development positive regulation of cell division positive regulation of cell population proliferation positive regulation of epithelial cell prol...
extrinsic apoptotic signaling pathway via death domain receptors memory modulation of chemical synaptic transmission negative regulation of cell population proliferation negative regulation of neuron apoptotic process nerve development nerve growth factor signaling pathway neuron projection morphogenesis peripheral ner...
axon; cytosol; dendrite; endosome lumen; extracellular region; extracellular space; Golgi lumen; synaptic vesicle
growth factor activity lipid binding metalloendopeptidase inhibitor activity nerve growth factor receptor binding
Homo sapiens
3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endosome Glycoprotein Growth factor Lipid-binding Metalloenzyme inhibitor Metalloprotease inhibitor Neurodegeneration Neuropathy Protease inhibitor Reference proteome Secreted Signal
MSMLFYTLIT
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA
extrinsic apoptotic signaling pathway via death domain receptors memory modulation of chemical synaptic transmission negative regulation of cell population proliferation negative regulation of neuron apoptotic process nerve development nerve growth factor signaling pathway neuron projection morphogenesis peripheral ner...
cell-cell signaling negative regulation of neuron migration regulation of gene expression regulation of ovarian follicle development reproduction response to ethanol response to steroid hormone signal transduction
extracellular region; extracellular space
gonadotropin hormone-releasing hormone activity gonadotropin-releasing hormone receptor binding hormone activity
Homo sapiens
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disease variant Hormone Hypogonadotropic hypogonadism Kallmann syndrome Pharmaceutical Pyrrolidone carboxylic acid Reference proteome Secreted Signal
MKPIQKLLAG
MKPIQKLLAGLILLTWCVEGCSSQHWSYGLRPGGKRDAENLIDSFQEIVKEVGQLAETQRFECTTHQPRSPLRDLKGALESLIEEETGQKKI
cell-cell signaling negative regulation of neuron migration regulation of gene expression regulation of ovarian follicle development reproduction response to ethanol response to steroid hormone signal transduction extracellular region; extracellular space gonadotropin hormone-releasing hormone activity gonadotropin-rel...
adult walking behavior eating behavior histamine metabolic process hormone-mediated signaling pathway negative regulation of feeding behavior negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion positive regulation of insulin secretion response to corticosterone response t...
extracellular region; secretory granule
thyrotropin-releasing hormone activity
Rattus norvegicus
Amidation Cleavage on pair of basic residues Hormone Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal
MPGPWLLLAL
MPGPWLLLALALIFTLTGIPESCALPEAAQEEGAVTPDLPGLENVQVRPERRFLWKDLQRVRGDLGAALDSWITKRQHPGKREEEEKDIEAEERGDLGEGGAWRLHKRQHPGRRANQDKYSWADEEDSDWMPRSWLPDFFLDSWFSDVPQVKRQHPGRRSFPWMESDVTKRQHPGRRFIDPELQRSWEEKEGEGVLMPEKRQHPGKRALGHPCGPQGTCGQTGLLQLLGDLSRGQETLVKQSPQVEPWDKEPLEE
adult walking behavior eating behavior histamine metabolic process hormone-mediated signaling pathway negative regulation of feeding behavior negative regulation of glutamate secretion positive regulation of gamma-aminobutyric acid secretion positive regulation of insulin secretion response to corticosterone response t...
aortic valve morphogenesis cardiac conduction system development cardiac muscle hypertrophy in response to stress cGMP biosynthetic process cGMP-mediated signaling female pregnancy negative regulation of JUN kinase activity negative regulation of systemic arterial blood pressure neuropeptide signaling pathway positive ...
cell projection; collagen-containing extracellular matrix; cytoplasm; extracellular region; extracellular space; perikaryon; protein-containing complex
hormone activity hormone receptor binding neuropeptide hormone activity neuropeptide receptor binding signaling receptor binding
Homo sapiens
3D-structure Atrial fibrillation Cardiomyopathy Cell projection Direct protein sequencing Disease variant Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal Vasoactive Vasodilator
MSSFSTTTVS
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY
aortic valve morphogenesis cardiac conduction system development cardiac muscle hypertrophy in response to stress cGMP biosynthetic process cGMP-mediated signaling female pregnancy negative regulation of JUN kinase activity negative regulation of systemic arterial blood pressure neuropeptide signaling pathway positive ...
intracellular protein transport neuropeptide signaling pathway peptide hormone processing regulation of hormone secretion
extracellular region; secretory granule
enzyme inhibitor activity enzyme regulator activity unfolded protein binding
Sus scrofa
Chaperone Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Neuropeptide Phosphoprotein Reference proteome Secreted Signal Sulfation Transport
MVSTMLSGLV
MVSTMLSGLVLWLTFGWTPALAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNTPKDFSEDQGYPDPPNPCPIGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE
intracellular protein transport neuropeptide signaling pathway peptide hormone processing regulation of hormone secretion extracellular region; secretory granule enzyme inhibitor activity enzyme regulator activity unfolded protein binding Sus scrofa Chaperone Cleavage on pair of basic residues Direct protein sequencing...
positive regulation of cold-induced thermogenesis response to estrogen
extracellular space; secretory granule
neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding
Bos taurus
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal
MAGSSLACCL
MAGSSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDVRTCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSPDGCHEDPACDPEAAFSQH
positive regulation of cold-induced thermogenesis response to estrogen extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding Bos taurus 3D-structure Amidation Cleavage on pair of basic residues Direct protein seq...
positive regulation of cold-induced thermogenesis signal transduction
extracellular region; extracellular space; secretory granule
neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding
Homo sapiens
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pharmaceutical Reference proteome Secreted Signal
MAGPSLACCL
MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPCGPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLGLCCSPDGCHADPACDAEATFSQR
positive regulation of cold-induced thermogenesis signal transduction extracellular region; extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity oxytocin receptor binding V1A vasopressin receptor binding Homo sapiens 3D-structure Amidation Cleavage on pair of basic resi...
vasoconstriction
extracellular space; secretory granule
neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding
Bos taurus
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor
MPDATLPACF
MPDATLPACFLSLLAFTSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGVGFPRRVRANDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY
vasoconstriction extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding Bos taurus 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal V...
vasoconstriction
extracellular space; secretory granule
neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding
Sus scrofa
Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor
MPDATLPACF
MPDATLPACFLGLLALTSACYFQNCPKGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGASFLRRARASDRSNATLLDGPSGALLLRLVQLAGAPEPAEPAQPGVY
vasoconstriction extracellular space; secretory granule neurohypophyseal hormone activity neuropeptide hormone activity V1A vasopressin receptor binding Sus scrofa Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vas...
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
cytoplasm; extracellular region; extracellular space; secretory granule; secretory granule lumen
G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding
Homo sapiens
3D-structure Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Obesity Phosphoprotein Reference proteome Secreted Signal
MPRSCCSRSG
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPMFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGGPEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
extracellular space; secretory granule
G protein-coupled receptor binding hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding
Bos taurus
Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation
MPRLCSSRSG
MPRLCSSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSSGVGGAAQKREEEVAVGEGPGPRGDDAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
extracellular space; secretory granule
hormone activity type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding
Ovis aries
Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Glycoprotein Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation
MPRLCSSRSG
MPRLCSSRSGALLLVLLLQASMEVRGWCLESSQCQDLTTESNLLACIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNGSSSFGAGGAAQKREEEVAVGEGPGPRGDGAETGPREDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAQAFPLEFKRELTGERLEQARGPEAQAESAAARAELEYGLVAEAEAAEKKDSGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin production positiv...
neuropeptide signaling pathway regulation of corticosterone secretion
extracellular space; secretory granule
G protein-coupled receptor binding hormone activity
Sus scrofa
Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Reference proteome Secreted Signal
MPRLCGSRSG
MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ
neuropeptide signaling pathway regulation of corticosterone secretion extracellular space; secretory granule G protein-coupled receptor binding hormone activity Sus scrofa Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Reference proteome Secreted Signal...
antimicrobial humoral immune response mediated by antimicrobial peptide calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis killing of cells of another organism modulation of process of another organism negative regulation of tumor necr...
cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule
G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding
Mus musculus
Acetylation Amidation Cleavage on pair of basic residues Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal
MPRFCYSRSG
MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACKLDLSLETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGSAAQRRAEEEAVWGDGSPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGERPLGLEQVLESDAEKDDGPYRVEHFRWSNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAHKKGQ
antimicrobial humoral immune response mediated by antimicrobial peptide calcium-mediated signaling cell-cell signaling cellular pigmentation generation of precursor metabolites and energy glucose homeostasis killing of cells of another organism modulation of process of another organism negative regulation of tumor necr...
calcium-mediated signaling cell-cell signaling cellular pigmentation feeding behavior generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin p...
cytoplasm; extracellular region; extracellular space; peroxisomal matrix; secretory granule
G protein-coupled receptor binding hormone activity signaling receptor binding type 1 melanocortin receptor binding type 3 melanocortin receptor binding type 4 melanocortin receptor binding
Rattus norvegicus
Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal
MPRFCNSRSG
MPRFCNSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLLACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRRAEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPLEFKRELEGEQPDGLEQVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNVHKKGQ
calcium-mediated signaling cell-cell signaling cellular pigmentation feeding behavior generation of precursor metabolites and energy glucose homeostasis negative regulation of tumor necrosis factor production neuropeptide signaling pathway positive regulation of cAMP-mediated signaling positive regulation of oxytocin p...
neuropeptide signaling pathway
extracellular region
hormone activity
Macaca nemestrina
Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal
MPRSCCSRSG
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSGSAHQKREDVAAGEDRGLLPEGGPEPRGDGAGPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKRELTGQRPRAGDGPDGPADDGAGPRADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIIKNAYKKGQ
neuropeptide signaling pathway extracellular region hormone activity Macaca nemestrina Acetylation Amidation Cleavage on pair of basic residues Direct protein sequencing Endorphin Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal MPRSCCSRSG MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAET...
aggressive behavior behavioral fear response cellular response to cAMP cellular response to oxidative stress cellular response to transforming growth factor beta stimulus cellular response to virus cellular response to vitamin D chemical synaptic transmission G protein-coupled opioid receptor signaling pathway general ...
axon terminus; cell body fiber; chromaffin granule lumen; dendrite; endoplasmic reticulum lumen; extracellular region; neuronal cell body; neuronal dense core vesicle lumen; perikaryon; plasma membrane; symmetric synapse; synaptic vesicle lumen
neuropeptide hormone activity opioid peptide activity opioid receptor binding
Homo sapiens
3D-structure Cleavage on pair of basic residues Cytoplasmic vesicle Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal
MARFLTLCTW
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF
aggressive behavior behavioral fear response cellular response to cAMP cellular response to oxidative stress cellular response to transforming growth factor beta stimulus cellular response to virus cellular response to vitamin D chemical synaptic transmission G protein-coupled opioid receptor signaling pathway general ...
aggressive behavior behavioral fear response chemical synaptic transmission defense response to bacterium G protein-coupled opioid receptor signaling pathway locomotory behavior neuropeptide signaling pathway sensory perception sensory perception of pain startle response transmission of nerve impulse
axon terminus; chromaffin granule lumen; dendrite; extracellular region; neuronal cell body; plasma membrane
opioid peptide activity opioid receptor binding
Bos taurus
3D-structure Antibiotic Antimicrobial Cleavage on pair of basic residues Cytoplasmic vesicle Direct protein sequencing Disulfide bond Endorphin Neuropeptide Opioid peptide Phosphoprotein Reference proteome Secreted Signal
MARFLGLCTW
MARFLGLCTWLLALGPGLLATVRAECSQDCATCSYRLARPTDLNPLACTLECEGKLPSLKTWETCKELLQLTKLELPPDATSALSKQEESHLLAKKYGGFMKRYGGFMKKMDELYPLEVEEEANGGEVLGKRYGGFMKKDAEEDDGLGNSSNLLKELLGAGDQREGSLHQEGSDAEDVSKRYGGFMRGLKRSPHLEDETKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEPLPSEEEGESYSKEVPEMEKRYGGFMRF
aggressive behavior behavioral fear response chemical synaptic transmission defense response to bacterium G protein-coupled opioid receptor signaling pathway locomotory behavior neuropeptide signaling pathway sensory perception sensory perception of pain startle response transmission of nerve impulse axon terminus; chr...
chemical synaptic transmission neuropeptide signaling pathway sensory perception
axon terminus; dendrite; extracellular region; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; plasma membrane
opioid peptide activity opioid receptor binding
Homo sapiens
3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endorphin Neurodegeneration Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal Spinocerebellar ataxia
MAWQGLVLAA
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
chemical synaptic transmission neuropeptide signaling pathway sensory perception axon terminus; dendrite; extracellular region; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; plasma membrane opioid peptide activity opioid receptor binding Homo sapiens 3D-structure Cleavage on p...
chemical synaptic transmission neuropeptide signaling pathway sensory perception
axon terminus; dendrite; extracellular region; neuronal cell body; plasma membrane
opioid peptide activity opioid receptor binding
Sus scrofa
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Neuropeptide Neurotransmitter Opioid peptide Reference proteome Secreted Signal
MAWQGLLLAA
MAWQGLLLAACLLVLPSTMADCLSGCSLCAVKTQDGPKPINPLICSLECQAALQPAEEWERCQGLLSFLAPLSLGLEGKEDLESKAALEEPSSELVKYMGPFLKELEKNRFLLSTPAEETSLSRSLVEKLRSLPGRLGEETESELMGDAQQNDGAMEAAALDSSVEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDRDKVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYYEELFDV
chemical synaptic transmission neuropeptide signaling pathway sensory perception axon terminus; dendrite; extracellular region; neuronal cell body; plasma membrane opioid peptide activity opioid receptor binding Sus scrofa Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Endorphin Neuropeptid...
follicle-stimulating hormone secretion follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway hormone-mediated signaling pathway luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of cell migration positive regulation of cell populatio...
extracellular region; extracellular space; follicle-stimulating hormone complex; Golgi lumen; pituitary gonadotropin complex
follicle-stimulating hormone activity hormone activity
Homo sapiens
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal
MDYYRKYAAI
MDYYRKYAAIFLVTLSVFLHVLHSAPDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS
follicle-stimulating hormone secretion follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway hormone-mediated signaling pathway luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of cell migration positive regulation of cell populatio...
cellular response to hormone stimulus developmental growth follicle-stimulating hormone secretion G protein-coupled receptor signaling pathway gonad development luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of steroid biosynthetic process regulation of signaling rece...
extracellular space; follicle-stimulating hormone complex; pituitary gonadotropin complex
follicle-stimulating hormone activity hormone activity
Mus musculus
Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal
MDYYRKYAAV
MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS
cellular response to hormone stimulus developmental growth follicle-stimulating hormone secretion G protein-coupled receptor signaling pathway gonad development luteinizing hormone secretion negative regulation of organ growth organ growth positive regulation of steroid biosynthetic process regulation of signaling rece...
anatomical structure morphogenesis cell-cell signaling G protein-coupled receptor signaling pathway response to calcium ion response to estrogen response to vitamin A
cytoplasm; extracellular region; extracellular space
hormone activity
Homo sapiens
3D-structure Alternative splicing Congenital hypothyroidism Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Pharmaceutical Reference proteome Secreted Signal
MTALFLMSML
MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV
anatomical structure morphogenesis cell-cell signaling G protein-coupled receptor signaling pathway response to calcium ion response to estrogen response to vitamin A cytoplasm; extracellular region; extracellular space hormone activity Homo sapiens 3D-structure Alternative splicing Congenital hypothyroidism Direct pro...
G protein-coupled receptor signaling pathway
cytoplasm; extracellular space
hormone activity
Bos taurus
Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal
MTATFLMSMI
MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYMVGFSI
G protein-coupled receptor signaling pathway cytoplasm; extracellular space hormone activity Bos taurus Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MTATFLMSMI MTATFLMSMIFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTVCAGYCMTRDVNGKLFLPKYALSQDVCTYRDFMYKTAEIPGCPRHVTPYFSYPVAISCKCGKC...
female gamete generation female pregnancy follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway positive regulation of bone resorption positive regulation of cell migration positive regulation of cell population proliferation positive regulation of gene expression positive regulati...
cytoplasm; extracellular region; extracellular space; follicle-stimulating hormone complex
follicle-stimulating hormone activity
Homo sapiens
3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Pharmaceutical Reference proteome Secreted Signal
MKTLQFFFLF
MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
female gamete generation female pregnancy follicle-stimulating hormone signaling pathway G protein-coupled receptor signaling pathway positive regulation of bone resorption positive regulation of cell migration positive regulation of cell population proliferation positive regulation of gene expression positive regulati...
cell-cell signaling G protein-coupled receptor signaling pathway hormone-mediated signaling pathway male gonad development progesterone biosynthetic process signal transduction
cytoplasm; extracellular region; extracellular space; Golgi lumen; pituitary gonadotropin complex
hormone activity signaling receptor binding
Homo sapiens
Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Hypogonadotropic hypogonadism Reference proteome Secreted Signal
MEMLQGLLLL
MEMLQGLLLLLLLSMGGAWASREPLRPWCHPINAILAVEKEGCPVCITVNTTICAGYCPTMMRVLQAVLPPLPQVVCTYRDVRFESIRLPGCPRGVDPVVSFPVALSCRCGPCRRSTSDCGGPKDHPLTCDHPQLSGLLFL
cell-cell signaling G protein-coupled receptor signaling pathway hormone-mediated signaling pathway male gonad development progesterone biosynthetic process signal transduction cytoplasm; extracellular region; extracellular space; Golgi lumen; pituitary gonadotropin complex hormone activity signaling receptor binding H...
estradiol secretion
extracellular region
hormone activity
Ovis aries
Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal
MEMLQGLLLW
MEMLQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCLSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL
estradiol secretion extracellular region hormone activity Ovis aries Direct protein sequencing Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal MEMLQGLLLW MEMLQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCLSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL
cell surface receptor signaling pathway female pregnancy lactation mammary gland development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation o...
endosome lumen; extracellular region; extracellular space
hormone activity prolactin receptor binding
Homo sapiens
3D-structure Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal
MNIKGSPWKG
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNLSSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWNEPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSGLPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC
cell surface receptor signaling pathway female pregnancy lactation mammary gland development negative regulation of angiogenesis negative regulation of endothelial cell proliferation positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation o...
cell population proliferation cellular response to hormone stimulus circadian rhythm epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior multicellular organismal response to stress negative regulation of endothelial cell proliferation ovulation cycle parturition positive...
extracellular region; extracellular space; secretory granule
hormone activity prolactin receptor binding
Rattus norvegicus
Direct protein sequencing Disulfide bond Hormone Lactation Phosphoprotein Reference proteome Secreted Signal
MNSQVSARKA
MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPELFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKVPPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKIISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRCQIVHKNNC
cell population proliferation cellular response to hormone stimulus circadian rhythm epithelial cell proliferation female pregnancy lactation mammary gland development maternal behavior multicellular organismal response to stress negative regulation of endothelial cell proliferation ovulation cycle parturition positive...
cellular response to hypoxia female pregnancy lactation mammary gland development negative regulation of estrogen biosynthetic process negative regulation of hydrogen peroxide biosynthetic process negative regulation of nitric oxide biosynthetic process negative regulation of progesterone biosynthetic process positive ...
extracellular space
hormone activity prolactin receptor binding
Sus scrofa
Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal
MDNRGSSQKG
MDNRGSSQKGSLLLLLLLVSNLFLCKSVASLPICPSGAVNCQVSLRDLFDRAVILSHYIHNLSSEMFNEFDKRYAQGRGFITKAINSCHTSSLSTPEDKEQAQQIHHEVLLNLILRVLRSWNDPLYHLVTEVRGMQEAPDAILSRAIEIEEQNKRLLEGMEKIVGQVHPGIKENEVYSVWSGLPSLQMADEDTRLFAFYNLLHCLRRDSHKIDNYLKLLKCRIIYDSNC
cellular response to hypoxia female pregnancy lactation mammary gland development negative regulation of estrogen biosynthetic process negative regulation of hydrogen peroxide biosynthetic process negative regulation of nitric oxide biosynthetic process negative regulation of progesterone biosynthetic process positive ...
biosynthetic process blastocyst formation lactation negative regulation of apoptotic process negative regulation of luteinizing hormone secretion negative regulation of nitric oxide mediated signal transduction negative regulation of peptide hormone secretion peptide hormone secretion positive regulation of fatty acid ...
extracellular space
hormone activity prolactin receptor binding
Ovis aries
Direct protein sequencing Disulfide bond Glycoprotein Hormone Lactation Phosphoprotein Reference proteome Secreted Signal
MDSKGSAQKG
MDSKGSAQKGSRLLLLLVVSNLLLCQGVVSTPVCPNGPGNCQVSLRDLFDRAVMVSHYIHNLSSEMFNEFDKRYAQGKGFITMALNSCHTSSLPTPEDKEQAQQTHHEVLMSLILGLLRSWNDPLYHLVTEVRGMKGVPDAILSRAIEIEEENKRLLEGMEMIFGQVIPGAKETEPYPVWSGLPSLQTKDEDARHSAFYNLLHCLRRDSSKIDTYLKLLNCRIIYNNNC
biosynthetic process blastocyst formation lactation negative regulation of apoptotic process negative regulation of luteinizing hormone secretion negative regulation of nitric oxide mediated signal transduction negative regulation of peptide hormone secretion peptide hormone secretion positive regulation of fatty acid ...
animal organ development bone maturation cytokine-mediated signaling pathway growth hormone receptor signaling pathway positive regulation of activation of Janus kinase activity positive regulation of glucose transmembrane transport positive regulation of growth positive regulation of insulin-like growth factor recepto...
endosome lumen; extracellular region; extracellular space; growth hormone receptor complex
cytokine activity growth factor activity growth hormone receptor binding hormone activity metal ion binding prolactin receptor binding
Homo sapiens
3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Dwarfism Hormone Metal-binding Pharmaceutical Phosphoprotein Reference proteome Secreted Signal Zinc
MATGSRTSLL
MATGSRTSLLLAFGLLCLPWLQEGSAFPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
animal organ development bone maturation cytokine-mediated signaling pathway growth hormone receptor signaling pathway positive regulation of activation of Janus kinase activity positive regulation of glucose transmembrane transport positive regulation of growth positive regulation of insulin-like growth factor recepto...
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels
endosome lumen; extracellular region; extracellular space
growth factor activity growth hormone receptor binding hormone activity
Homo sapiens
Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal
MAAGSRTSLL
MAAGSRTSLLLAFGLLCLSWLQEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLEPVQLLRSVFANSLVYGASDSNVYRHLKDLEEGIQTLMWRLEDGSPRTGQIFNQSYSKFDTKSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels endosome lumen; extracellular region; extracellular space growth fac...
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels
extracellular space
growth factor activity growth hormone receptor binding hormone activity metal ion binding
Sus scrofa
Direct protein sequencing Disulfide bond Hormone Metal-binding Phosphoprotein Reference proteome Secreted Signal Zinc
MAAGPRTSAL
MAAGPRTSALLAFALLCLPWTREVGAFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
animal organ development growth hormone receptor signaling pathway positive regulation of growth positive regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of tyrosine phosphorylation of STAT protein response to nutrient levels extracellular space g...
activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure cellular response to nerve growth factor stimulus cellular response to tumor necrosis factor detection of te...
extracellular region; extracellular space; hippocampal mossy fiber to CA3 synapse; neuronal cell body; neuronal dense core vesicle; terminal bouton
calcitonin receptor binding hormone activity identical protein binding
Homo sapiens
3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Phosphoprotein Reference proteome Secreted Signal
MGFQKFSPFL
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN
activation of protein kinase activity adenylate cyclase-activating G protein-coupled receptor signaling pathway artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure cellular response to nerve growth factor stimulus cellular response to tumor necrosis factor detection of te...
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expres...
extracellular space
hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding
Bos taurus
3D-structure Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal
MMSAKDMVKV
MMSAKDMVKVMIVMLAICFLARSDGKSVKKRAVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNFVALGASIAYRDGSSQRPRKKEDNVLVESHQKSLGEADKADVDVLIKAKPQ
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expres...
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expres...
extracellular space
hormone activity parathyroid hormone receptor binding peptide hormone receptor binding type 1 parathyroid hormone receptor binding
Sus scrofa
Cleavage on pair of basic residues Direct protein sequencing Hormone Reference proteome Secreted Signal
MMSAKDTVKV
MMSAKDTVKVMVVMLAICFLARSDGKPIKKRSVSEIQLMHNLGKHLSSLERVEWLRKKLQDVHNFVALGASIVHRDGGSQRPRKKEDNVLVESHQKSLGEADKAAVDVLIKAKPQ
adenylate cyclase-activating G protein-coupled receptor signaling pathway bone mineralization cell-cell signaling homeostasis of number of cells within a tissue intracellular calcium ion homeostasis magnesium ion homeostasis negative regulation of apoptotic process in bone marrow cell negative regulation of gene expres...
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis lactate biosynthetic process lipid biosynthetic process negative regulation of apoptotic process ...
cytoplasm; extracellular space; plasma membrane
glucagon receptor binding hormone activity identical protein binding
Bos taurus
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal
MKSLYFVAGL
MKSLYFVAGLFVMLVQGSWQRSLQNTEEKSSSFPAPQTDPLGDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVNIVEELRRRHADGSFSDEMNTVLDSLATRDFINWLLQTKITDRK
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis lactate biosynthetic process lipid biosynthetic process negative regulation of apoptotic process ...
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis posi...
cytoplasm; extracellular space; plasma membrane
glucagon receptor binding hormone activity identical protein binding
Sus scrofa
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal
MKTIYFVAGL
MKTIYFVAGLFVMLVQGSWQRSLQNTEEKSRSFPAPQTDPLDDPDQMTEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVTIVEELRRRHADGSFSDEMNTVLDNLATRDFINWLLHTKITDSL
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus gluconeogenesis glucose homeostasis negative regulation of apoptotic process negative regulation of execution phase of apoptosis posi...
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus feeding behavior G protein-coupled receptor signaling pathway gluconeogenesis glucose homeostasis negative regulation of apoptotic pr...
endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane; secretory granule lumen
glucagon receptor binding hormone activity identical protein binding signaling receptor binding
Homo sapiens
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Phosphoprotein Reference proteome Secreted Signal
MKSIYFVAGL
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus feeding behavior G protein-coupled receptor signaling pathway gluconeogenesis glucose homeostasis negative regulation of apoptotic pr...
adenylate cyclase-activating G protein-coupled receptor signaling pathway body fluid secretion epinephrine secretion G protein-coupled receptor signaling pathway learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth mu...
extracellular region; neuron projection
hormone activity neuropeptide hormone activity peptide hormone receptor binding
Homo sapiens
3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Reference proteome Secreted Signal
MDTRNKAQLL
MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
adenylate cyclase-activating G protein-coupled receptor signaling pathway body fluid secretion epinephrine secretion G protein-coupled receptor signaling pathway learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth mu...
adenylate cyclase-activating G protein-coupled receptor signaling pathway epinephrine secretion learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupl...
extracellular region; neuron projection; neuronal cell body
hormone activity neuropeptide hormone activity peptide hormone receptor binding signaling receptor binding
Rattus norvegicus
Amidation Cleavage on pair of basic residues Direct protein sequencing Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal
MESRSKPQFL
MESRSKPQFLAILTLFSVLFSQSLAWPLYGPPSSVRLDDRLQFEGAGDPDQVSLKADSDILQNALAENDTPYYDVSRNARHADGVFTSDYSRLLGQISAKKYLESLIGKRISSSISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGDSPDFLEELEK
adenylate cyclase-activating G protein-coupled receptor signaling pathway epinephrine secretion learning or memory mRNA stabilization negative regulation of apoptotic process negative regulation of potassium ion transport negative regulation of smooth muscle cell proliferation phospholipase C-activating G protein-coupl...
adenohypophysis development adenylate cyclase-activating G protein-coupled receptor signaling pathway cell-cell signaling growth hormone secretion multicellular organism growth positive regulation of cell population proliferation positive regulation of circadian sleep/wake cycle, REM sleep positive regulation of growth...
extracellular region; extracellular space; perikaryon; terminal bouton
growth hormone-releasing hormone activity growth hormone-releasing hormone receptor binding neuropeptide hormone activity peptide hormone receptor binding
Homo sapiens
3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Pharmaceutical Reference proteome Secreted Signal
MPLWVFFFVI
MPLWVFFFVILTLSNSSHCSPPPPLTLRMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARLGRQVDSMWAEQKQMELESILVALLQKHSRNSQG
adenohypophysis development adenylate cyclase-activating G protein-coupled receptor signaling pathway cell-cell signaling growth hormone secretion multicellular organism growth positive regulation of cell population proliferation positive regulation of circadian sleep/wake cycle, REM sleep positive regulation of growth...
chemical synaptic transmission inflammatory response neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration response to pain sensory perception of pain tachykinin receptor signaling pathway
axon; extracellular region; extracellular space; neuronal cell body; synapse
substance P receptor binding
Bos taurus
Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Neuropeptide Neurotransmitter Reference proteome Secreted Signal
MKILVAVAVI
MKILVAVAVIFFISTQLSAEEIGANDDFNYWSDWSDSDQIKEEMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQLSHKRHKTDSFVGLMGKRALNSVAYERSVMQDYERRRK
chemical synaptic transmission inflammatory response neuropeptide signaling pathway positive regulation of cytosolic calcium ion concentration response to pain sensory perception of pain tachykinin receptor signaling pathway axon; extracellular region; extracellular space; neuronal cell body; synapse substance P recept...
feeding behavior neuropeptide signaling pathway protein secretion
cytoplasm; extracellular region; extracellular space
G protein-coupled receptor binding hormone activity neuropeptide hormone activity neuropeptide Y receptor binding
Homo sapiens
3D-structure Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Pharmaceutical Reference proteome Secreted Signal
MAAARLCLSL
MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL
feeding behavior neuropeptide signaling pathway protein secretion cytoplasm; extracellular region; extracellular space G protein-coupled receptor binding hormone activity neuropeptide hormone activity neuropeptide Y receptor binding Homo sapiens 3D-structure Alternative splicing Amidation Cleavage on pair of basic resi...
adult feeding behavior central nervous system neuron development cerebral cortex development chemical synaptic transmission feeding behavior G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger intestinal epithelial cell differentiation neuron projection development neuropeptide s...
extracellular region; extracellular space; GABA-ergic synapse; Golgi apparatus; neuronal dense core vesicle
calcium channel regulator activity G protein-coupled receptor activity neuropeptide hormone activity neuropeptide Y receptor binding signaling receptor binding
Homo sapiens
3D-structure Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Neuropeptide Phosphoprotein Reference proteome Secreted Signal
MLGNKRLGLS
MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
adult feeding behavior central nervous system neuron development cerebral cortex development chemical synaptic transmission feeding behavior G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger intestinal epithelial cell differentiation neuron projection development neuropeptide s...
estradiol secretion feeding behavior glucose homeostasis glucose import in response to insulin stimulus glucose metabolic process negative regulation of apoptotic process negative regulation of appetite negative regulation of lactation negative regulation of lipid catabolic process positive regulation of blood circulat...
extracellular space
hormone activity identical protein binding insulin receptor binding
Bos taurus
3D-structure Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal
MALWTRLRPL
MALWTRLRPLLALLALWPPPPARAFVNQHLCGSHLVEALYLVCGERGFFYTPKARREVEGPQVGALELAGGPGAGGLEGPPQKRGIVEQCCASVCSLYQLENYCN
estradiol secretion feeding behavior glucose homeostasis glucose import in response to insulin stimulus glucose metabolic process negative regulation of apoptotic process negative regulation of appetite negative regulation of lactation negative regulation of lipid catabolic process positive regulation of blood circulat...
cellular response to glucose stimulus cellular response to oxygen-containing compound glucose homeostasis glucose metabolic process insulin receptor signaling pathway positive regulation of protein secretion receptor internalization response to cAMP response to cytokine response to organic substance response to peptide...
cytosol; extracellular space
hormone activity insulin receptor binding
Rattus norvegicus
Carbohydrate metabolism Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glucose metabolism Hormone Reference proteome Secreted Signal
MALWMRFLPL
MALWMRFLPLLALLVLWEPKPAQAFVKQHLCGPHLVEALYLVCGERGFFYTPKSRREVEDPQVPQLELGGGPEAGDLQTLALEVARQKRGIVDQCCTSICSLYQLENYCN
cellular response to glucose stimulus cellular response to oxygen-containing compound glucose homeostasis glucose metabolic process insulin receptor signaling pathway positive regulation of protein secretion receptor internalization response to cAMP response to cytokine response to organic substance response to peptide...
adenylate cyclase-modulating G protein-coupled receptor signaling pathway developmental growth mammary gland morphogenesis negative regulation of apoptotic process nipple development prostate gland growth regulation of apoptotic process regulation of body fluid levels regulation of cell population proliferation regulat...
extracellular region
hormone activity signaling receptor binding
Rattus norvegicus
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal
MSSRLLLQLL
MSSRLLLQLLGFWLFLSQPCRARVSEEWMDQVIQVCGRGYARAWIEVCGASVGRLALSQEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNLSEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSDAQSRKKRQSGALLSEQCCHIGCTRRSIAKLC
adenylate cyclase-modulating G protein-coupled receptor signaling pathway developmental growth mammary gland morphogenesis negative regulation of apoptotic process nipple development prostate gland growth regulation of apoptotic process regulation of body fluid levels regulation of cell population proliferation regulat...
blastocyst growth flagellated sperm motility oocyte maturation positive regulation of acrosome reaction positive regulation of epithelial cell proliferation positive regulation of glucose import
extracellular region
hormone activity
Sus scrofa
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Pyrrolidone carboxylic acid Reference proteome Secreted Signal
MPRLFSYLLG
MPRLFSYLLGVWLLLSQLPREIPGQSTNDFIKACGRELVRLWVEICGSVSWGRTALSLEEPQLETGPPAETMPSSITKDAEILKMMLEFVPNLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLDKHSRKKRLFRMTLSEKCCQVGCIRKDIARLC
blastocyst growth flagellated sperm motility oocyte maturation positive regulation of acrosome reaction positive regulation of epithelial cell proliferation positive regulation of glucose import extracellular region hormone activity Sus scrofa Cleavage on pair of basic residues Direct protein sequencing Disulfide bond ...
G protein-coupled receptor signaling pathway response to food signal transduction
extracellular region; extracellular space
hormone activity
Homo sapiens
3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Signal Sulfation
MQRLCVYVLI
MQRLCVYVLIFALALAAFSEASWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDFGRRSAEDEN
G protein-coupled receptor signaling pathway response to food signal transduction extracellular region; extracellular space hormone activity Homo sapiens 3D-structure Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Secreted Sig...
axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regula...
axon; axon hillock; axon initial segment; dendrite; extracellular region; extracellular space; GABA-ergic synapse; neuronal cell body; perikaryon; terminal bouton
hormone activity neuropeptide hormone activity peptide hormone receptor binding receptor ligand activity
Rattus norvegicus
Amidation Cleavage on pair of basic residues Hormone Reference proteome Secreted Signal Sulfation
MKCGVCLCVV
MKCGVCLCVVMAVLAAGALAQPVVPVEAVDPMEQRAEEAPRRQLRAVLRPDSEPRARLGALLARYIQQVRKAPSGRMSVLKNLQGLDPSHRISDRDYMGWMDFGRRSAEDYEYPS
axonogenesis cholecystokinin signaling pathway digestion eating behavior memory negative regulation of appetite negative regulation of behavioral fear response negative regulation of eating behavior neuron migration positive regulation of apoptotic process positive regulation of behavioral fear response positive regula...
neuropeptide signaling pathway
extracellular region
hormone activity
Aplysia californica
Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Secreted Signal
MKRPNNRPTN
MKRPNNRPTNTMSLILCLTLSSLCVSSQSASVHGKNFATNRAVKSSSPFVVLSPDDNVVSMSGENGYRSALREAFDKSSRDYDDNGEDVFSNEKRRLRFHKRRLRFDRRDQDEGNFRRFPTNAVSMSADENSPFDLSNEDGAVYQRDLRAPRLRFYSLRKRAAGGMEQSEGQNPETESHSRRKRSVLTPSLSSLGESLESGISKRISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEKGKRSSGVSLLTSNKDEEQRELLKAISNLLD
neuropeptide signaling pathway extracellular region hormone activity Aplysia californica Alternative splicing Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Secreted Signal MKRPNNRPTN MKRPNNRPTNTMSLILCLTLSSLCVSSQSASVHGKNFATNRAVKSSSPFVVLSPDDNVVSMSGENGYRSALREAFDKSSRDYDDNGEDVFS...
apoptotic process cell-cell signaling defense response to Gram-positive bacterium humoral immune response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of glia...
extracellular space; plasma membrane
cytokine activity signaling receptor binding tumor necrosis factor receptor binding
Homo sapiens
3D-structure Cytokine Direct protein sequencing Glycoprotein Membrane Reference proteome Secreted Signal
MTPPERLFLP
MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL
apoptotic process cell-cell signaling defense response to Gram-positive bacterium humoral immune response lymph node development negative regulation of fibroblast proliferation positive regulation of apoptotic process positive regulation of chronic inflammatory response to antigenic stimulus positive regulation of glia...
killing of cells of another organism
extracellular region; membrane; other organism cell membrane
toxin activity
Naja kaouthia
3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Membrane Secreted Target cell membrane Target membrane Toxin
LKCNKLIPLA
LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDVCPKNSLLVKYVCCNTDRCN
killing of cells of another organism extracellular region; membrane; other organism cell membrane toxin activity Naja kaouthia 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Membrane Secreted Target cell membrane Target membrane Toxin LKCNKLIPLA LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDVCPK...
killing of cells of another organism modulation of process of another organism
extracellular region; membrane; other organism cell membrane
toxin activity
Naja kaouthia
3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Membrane Secreted Target cell membrane Target membrane Toxin
LKCNKLIPLA
LKCNKLIPLAYKTCPAGKNLCYKMFMVSNKTVPVKRGCIDACPKNSLLVKYVCCNTDRCN
killing of cells of another organism modulation of process of another organism extracellular region; membrane; other organism cell membrane toxin activity Naja kaouthia 3D-structure Cardiotoxin Cytolysis Direct protein sequencing Disulfide bond Glycoprotein Membrane Secreted Target cell membrane Target membrane Toxin ...
defense response
extracellular region
sodium channel inhibitor activity toxin activity
Androctonus australis
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
MNYLVMISLA
MNYLVMISLALLFVTGVESVKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVRTKGPGRCHGR
defense response extracellular region sodium channel inhibitor activity toxin activity Androctonus australis 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin MNYLVMISLA MNYLVMISLALLFVTGVESVKDGYIVDDVN...
defense response
extracellular region
sodium channel inhibitor activity toxin activity
Buthus occitanus tunetanus
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
LVMAGVESVK
LVMAGVESVKDGYIVDDRNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKVPDHVRTKGPGRCN
defense response extracellular region sodium channel inhibitor activity toxin activity Buthus occitanus tunetanus Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin LVMAGVESVK LVMAGVESVKDGYIVDDRNCTYFCGRNAYCNEECTKL...
defense response
extracellular region
sodium channel inhibitor activity toxin activity
Leiurus quinquestriatus quinquestriatus
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
GVRDAYIADD
GVRDAYIADDKNCVYTCGSNSYCNTECTKNGAESGYCQWLGKYGNACWCIKLPDKVPIRIPGKCR
defense response extracellular region sodium channel inhibitor activity toxin activity Leiurus quinquestriatus quinquestriatus 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin GVRDAYIADD GVRDAYIADDKNCVYTCG...
defense response
extracellular region
sodium channel inhibitor activity toxin activity
Centruroides sculpturatus
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin
MNSLLIITAC
MNSLLIITACFALVGTVWAKEGYLVKKSDGCKYDCFWLGKNEHCDTECKAKNQGGSYGYCYAFACWCEGLPESTPTYPLPNKSCGKK
defense response extracellular region sodium channel inhibitor activity toxin activity Centruroides sculpturatus 3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Signal Toxin Voltage-gated sodium channel impairing toxin MNSLLIITAC MNSLLIITACFALVGTVWAKEGYLVK...
modulation of process of another organism negative regulation of inward rectifier potassium channel activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transporter activity
extracellular region
inward rectifier potassium channel inhibitor activity potassium channel inhibitor activity toxin activity
Apis mellifera
3D-structure Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Signal Toxin Voltage-gated potassium channel impairing toxin
MISMLRCIYL
MISMLRCIYLFLSVILITSYFVTPVMPCNCKAPETALCARRCQQHG
modulation of process of another organism negative regulation of inward rectifier potassium channel activity negative regulation of potassium ion transmembrane transport negative regulation of potassium ion transmembrane transporter activity extracellular region inward rectifier potassium channel inhibitor activity pot...
killing of cells of another organism localization monoatomic ion transport
extracellular region; other organism cell membrane; pore complex
lipid binding molecular function inhibitor activity porin activity protein kinase inhibitor activity toxin activity
Apis mellifera
3D-structure Allergen Amidation Antimicrobial Cytolysis Direct protein sequencing Formylation Hemolysis Ion transport Membrane Pharmaceutical Porin Reference proteome Secreted Signal Target cell membrane Target membrane Toxin Transmembrane Transport
MKFLVNVALV
MKFLVNVALVFMVVYISYIYAAPEPEPAPEPEAEADAEADPEAGIGAVLKVLTTGLPALISWIKRKRQQG
killing of cells of another organism localization monoatomic ion transport extracellular region; other organism cell membrane; pore complex lipid binding molecular function inhibitor activity porin activity protein kinase inhibitor activity toxin activity Apis mellifera 3D-structure Allergen Amidation Antimicrobial Cyt...
regulation of signal transduction
extracellular region; nematocyst
sodium channel regulator activity toxin activity
Anthopleura xanthogrammica
3D-structure Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
GVPCLCDSDG
GVPCLCDSDGPRPRGNTLSGILWFYPSGCPSGWHNCKAHGPNIGWCCKK
regulation of signal transduction extracellular region; nematocyst sodium channel regulator activity toxin activity Anthopleura xanthogrammica 3D-structure Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin ...
localization positive regulation of tyrosine phosphorylation of STAT protein
catalytic complex; extracellular space; periplasmic space
galactose binding glycosyltransferase activity lipid binding nucleotidyltransferase activity toxin activity
Vibrio cholerae serotype O1
3D-structure Direct protein sequencing Disulfide bond Enterotoxin Glycosyltransferase NAD Nucleotidyltransferase Reference proteome Signal Toxin Transferase Virulence
MVKIIFVFFI
MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL
localization positive regulation of tyrosine phosphorylation of STAT protein catalytic complex; extracellular space; periplasmic space galactose binding glycosyltransferase activity lipid binding nucleotidyltransferase activity toxin activity Vibrio cholerae serotype O1 3D-structure Direct protein sequencing Disulfide ...
positive regulation of tyrosine phosphorylation of STAT protein
catalytic complex; extracellular region; host cell plasma membrane; membrane; periplasmic space
galactose binding host cell surface binding toxin activity
Vibrio cholerae serotype O1
3D-structure Direct protein sequencing Disulfide bond Enterotoxin Host cell membrane Host membrane Membrane Reference proteome Secreted Signal Toxin Virulence
MIKLKFGVFF
MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAIITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMAN
positive regulation of tyrosine phosphorylation of STAT protein catalytic complex; extracellular region; host cell plasma membrane; membrane; periplasmic space galactose binding host cell surface binding toxin activity Vibrio cholerae serotype O1 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Host ce...
adaptive immune response B cell differentiation B cell proliferation cellular response to virus cytokine-mediated signaling pathway defense response to virus humoral immune response natural killer cell activation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein response...
extracellular region; extracellular space
cytokine activity type I interferon receptor binding
Homo sapiens
3D-structure Antiviral defense Cytokine Direct protein sequencing Disulfide bond Reference proteome Secreted Signal
MASPFALLMV
MASPFALLMVLVVLSCKSSCSLGCDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE
adaptive immune response B cell differentiation B cell proliferation cellular response to virus cytokine-mediated signaling pathway defense response to virus humoral immune response natural killer cell activation involved in immune response positive regulation of peptidyl-serine phosphorylation of STAT protein response...