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10.1002/adfm.201807173 | 104,352,701 | Abstract Current in vitro antitumor drug screening strategies insufficiently mimic biological systems. They tend to lack true perfusion and draining microcirculation systems, which may post significant limitations in explicitly reproducing the transport kinetics of cancer therapeutics. Herein, the fabrication of an imp... | 10.1038/s41568-022-00514-w | This study describes 3D bioprinted models containing combinations of various blood and lymphatic vessel pairs with different diffusion profiles for biomolecules and anticancer therapies |
10.1002/art.40807 | 62,587,186 | Objective To estimate the current prevalence rates and decadal trends of gout and hyperuricemia in the US, as well as the prevalence of urate‐lowering therapy (ULT) among gout patients, using 2007–2016 data from a nationally representative survey of American men and women (the National Health and Nutrition Examination ... | 10.1038/s41572-019-0115-y | This article describes the contemporary epidemiology of gout and hyperuricaemia in the USA |
10.1002/acr.22585 | 20,113,588 | Objective To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non‐gout. Methods We performed a cross‐sectional study of consecutive rheumatology clinic patients with ≥1 swollen joint or subcutaneous tophus. Gout was defined by synovial fluid or tophus aspirate microscop... | 10.1038/s41572-019-0115-y | This study describes the major clinical features of gout in a large multicentre study, using monosodium urate crystal identification as the gold standard |
10.1136/annrheumdis-2017-211574 | 41,261,352 | Objectives To determine whether febuxostat with stepwise dose increase is as useful as colchicine prophylaxis in reducing gout flares during the initial introduction of urate-lowering therapy in patients with gout in comparison with febuxostat with no dose titration. Methods In this prospective, multicentre, randomised... | 10.1038/s41572-019-0115-y | This clinical trial showed that gradual escalation of the febuxostat dose reduces the risk of gout flares compared with full-dose febuxostat when starting urate-lowering therapy; this study also demonstrated the efficacy of low-dose colchicine (0.5 mg daily) in reducing gout flares when initiating urate-lowering therap... |
10.1136/annrheumdis-2016-210872 | 101,287,769 | Objectives To determine the efficacy and safety of allopurinol dose escalation using a treat-to-target serum urate (SU) approach. Methods A randomised, controlled, parallel-group, comparative clinical trial was undertaken. People with gout receiving at least creatinine clearance (CrCL)-based allopurinol dose for ≥1 mon... | 10.1038/s41572-019-0115-y | This randomized controlled trial showed that allopurinol dose escalation can be used to attain a target serum urate concentration in most patients with gout |
10.1073/pnas.0409500102 | 83,390,626 | Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and... | 10.1038/s41572-019-0115-y | This was the original description of HLA-B*5801 as a genetic marker for allopurinol-induced SCAR |
10.1083/jcb.200809125 | 83,513,758 | Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron maintenance is unknown, recent work has linked Parkin to the regulation of mitochondria. Its loss is associated with swollen mitochondri... | 10.1038/s41580-022-00542-2 | The authors demonstrate the novel role of Parkin in mitophagy. Parkin is selectively recruited to damaged mitochondria and is critical for their autophagic degradation |
10.1083/jcb.201607039 | 41,471,319 | Members of the Atg8 family of proteins are conjugated to autophagosomal membranes, where they have been proposed to drive autophagosome formation and selective sequestration of cargo. In mammals, the Atg8 family consists of six members divided into the LC3 and GABARAP subfamilies. To define Atg8 function, we used genom... | 10.1038/s41580-022-00542-2 | Using CRISPR-gene editing to knockout genes encoding the LC3/GABARAP family proteins, this work shows that these proteins are dispensable for autophagosome formation but are instead essential for the acidification of autophagosomes through their role in autophagosome–lysosome fusion |
10.1083/jcb.201912144 | 81,270,019 | Damaged mitochondria are selectively eliminated in a process called mitophagy. Parkin and PINK1, proteins mutated in Parkinson’s disease, amplify ubiquitin signals on damaged mitochondria with the subsequent activation of autophagic machinery. Autophagy adaptors are thought to link ubiquitinated mitochondria and autoph... | 10.1038/s41580-022-00542-2 | This study reveals that the association between OPTN and ATG9A is important for mitophagy, suggesting that OPTN localizes ATG9A vesicles to provide membranes for mitophagy |
10.1083/jcb.200507002 | 41,664,928 | Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic machinery recognizes such aggregates. In this study, we report that polymerization of the polyubiquitin-binding protein p62/SQSTM1 yields protein bodies that either reside free in the cytoso... | 10.1038/s41580-022-00542-2 | This paper initially identifie the LIR domain and highlighted, for the first time, the role of p62 in aggrephagy |
10.1083/jcb.201304188 | 82,713,771 | Although ubiquitin is thought to be important for the autophagic sequestration of invading bacteria (also called xenophagy), its precise role remains largely enigmatic. Here we determined how ubiquitin is involved in this process. After invasion, ubiquitin is conjugated to host cellular proteins in endosomes that conta... | 10.1038/s41580-022-00542-2 | This study shows that a damaged endosomal membrane causes ubiquitin-coating and autophagosomal membrane formation on the targets for selective autophagy using the artificial polystyrene beads coated with transfection reagent, which damages the membrane |
10.4049/jimmunol.0900441 | 83,087,618 | Abstract Autophagy, a cellular degradative pathway, plays a key role in protecting the cytosol from bacterial colonization, but the mechanisms of bacterial recognition by this pathway are unclear. Autophagy is also known to degrade cargo tagged by ubiquitinated proteins, including aggregates of misfolded proteins, and ... | 10.1038/s41580-022-00542-2 | This is a classic study that establishes that receptor protein p62 is recruited to invading Salmonella and facilitate their autophagic degradation |
10.1002/hep.28572 | 125,121,652 | There is evidence that nonalcoholic fatty liver disease (NAFLD) is affected by gut microbiota. Therefore, we investigated its modifications in pediatric NAFLD patients using targeted metagenomics and metabolomics. Stools were collected from 61 consecutive patients diagnosed with nonalcoholic fatty liver (NAFL), nonalco... | 10.1038/s41575-020-0269-9 | This work provides a microbial signature of NAFLD–NASH in children and uses several control groups (one of individuals with obesity without NAFLD and one of healthy individuals) |
10.1073/pnas.0812819106 | 45,375,655 | A mouse neurological mutant, lister , was identified through a genome-wide N -ethyl- N -nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger protein, LISTERIN, which functions as an E3 ubiquitin ligase ... | 10.1038/s41580-019-0118-2 | This study establishes a first link between listerin–RQC and neurodegeneration |
10.1073/pnas.1221724110 | 20,680,579 | Ribosome stalling on eukaryotic mRNAs triggers cotranslational RNA and protein degradation through conserved mechanisms. For example, mRNAs lacking a stop codon are degraded by the exosome in association with its cofactor, the SKI complex, whereas the corresponding aberrant nascent polypeptides are ubiquitinated by the... | 10.1038/s41580-019-0118-2 | This study and that of Brandman et al. (2012) report the results of a powerful combination of genetic and proteomic analyses, uncovering that Ltn1 functions together with cofactors in an RQC complex |
10.1073/pnas.1413882111 | 103,994,422 | Significance All organisms have systems in place to ensure that aberrant nascent polypeptide chains are promptly dealt with before being released from ribosomes and posing harm to the cell. The ribosome-associated quality control complex (RQC), composed of the Ltn1 E3 ubiquitin ligase catalytic subunit and cofactors, h... | 10.1038/s41580-019-0118-2 | This study reports the first cryo-EM structure of the RQC complex, identifying Rqc2 as the subunit that senses obstructed 60S subunits and setting forth novel principles of substrate recognition and selectivity in protein quality control |
10.1038/s41467-018-04564-3 | 45,522,031 | Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to stall. The RQC comprises the E3 ubiquitin ligase Ltn1p, the ATPase Cdc48p, Rqc1p, and Rqc2p. Upon ribosome stalling and splitting, the RQC assembles on the 60S species c... | 10.1038/s41580-019-0118-2 | Together with Verma et al. (2018), this study reports that Vms1 acts in releasing the nascent chain from tRNA in an obstructed 60S–peptidyl-tRNA complex |
10.5194/tc-7-375-2013 | 122,990,044 | Abstract. We present Bedmap2, a new suite of gridded products describing surface elevation, ice-thickness and the seafloor and subglacial bed elevation of the Antarctic south of 60° S. We derived these products using data from a variety of sources, including many substantial surveys completed since the original Bedmap ... | 10.1038/s41586-018-0171-6 | This paper presents models of the Antarctic ice sheet and ice shelf thickness, determined from a compilation of airborne and satellite remote sensing, that are widely used across the glaciological community and beyond. |
10.1126/science.220.4601.1005 | 79,683,536 | A definitive long-term decrease in the extent of antarctic sea ice is not detectable from 9 years (1973 to 1981) of year-round satellite observations and limited prior data. Regional interannual variability is large, with sea ice decreasing in some regions while increasing in others. A significant decrease in overall i... | 10.1038/s41586-018-0171-6 | As an early application of satellite radar imagery for tracking trends in the extent of sea ice in the Southern Hemisphere, this paper is a seminal study. |
10.1126/science.aaa0940 | 20,759,744 | Disappearing faster around the edges The floating ice shelves around Antarctica, which buttress ice streams from the continent and slow their discharge into the sea, are thinning at faster rates. Paolo et al. present satellite data showing that ice shelves in many regions around the edge of the continent are losing mas... | 10.1038/s41586-018-0171-6 | A multi-mission record (1994 to 2012) of ice-shelf surface height from satellite radar altimetry showed accelerated loss of volume of Antarctica’s ice shelves, with early increases in East Antarctica, probably due to accumulation, and substantial losses in West Antarctica, where some ice shelves thinned by up to 18% ov... |
10.1126/science.1089768 | 82,899,614 | The retreat and collapse of Antarctic Peninsula ice shelves in tandem with a regional atmospheric warming has fueled speculation as to how these events may be related. Satellite radar altimeter measurements show that between 1992 and 2001 the Larsen Ice Shelf lowered by up to 0.27 ± 0.11 meters per year. The lowering i... | 10.1038/s41586-018-0171-6 | This paper describes the first application of satellite measurements for detecting trends in the thickness of Antarctic ice shelves, providing direct observations of contemporary imbalance and evidence that ocean-driven melting is a destabilizing force. |
10.1126/science.287.5456.1248 | 41,385,057 | It has been suggested that as much as 90% of the discharge from the Antarctic Ice Sheet is drained through a small number of fast-moving ice streams and outlet glaciers fed by relatively stable and inactive catchment areas. Here, evidence obtained from balance velocity estimates suggests that each major drainage basin ... | 10.1038/s41586-018-0171-6 | This study was the first to apply the balance-velocity technique to map the continental pattern of ice flow, revealing the intricate nature of the ice sheet glaciers. |
10.1126/science.262.5139.1525 | 83,493,849 | Satellite radar interferometry (SRI) provides a sensitive means of monitoring the flow velocities and grounding-line positions of ice streams, which are indicators of response of the ice sheets to climatic change or internal instability. The detection limit is about 1.5 millimeters for vertical motions and about 4 mill... | 10.1038/s41586-018-0171-6 | This ground-breaking study was the first to explain how the innovative technique of satellite radar interferometry could be applied to glaciology, introducing methods for tracking glacier topography and motion, and the location of ice stream grounding lines. |
10.1029/2004gl021387 | 19,012,534 | RADARSAT data from the 1997 Antarctic Mapping Mission are used interferometrically to solve for the 3‐dimensional surface ice motion in the interior of the West Antarctic Ice Sheet (WAIS). An area of ∼125 km 2 in a tributary of the Kamb Ice Stream slumped vertically downwards by up to ∼50 cm between September 26 and Oc... | 10.1038/s41586-018-0171-6 | This study was the first to detect the surface expression of water transport beneath the Antarctic ice sheet, a new approach for studying the hydrology of the continent’s subglacial lakes |
10.1126/science.1070942 | 29,101,983 | As continental ice from Antarctica reaches the grounding line and begins to float, its underside melts into the ocean. Results obtained with satellite radar interferometry reveal that bottom melt rates experienced by large outlet glaciers near their grounding lines are far higher than generally assumed. The melting rat... | 10.1038/s41586-018-0171-6 | In reporting satellite-derived estimates of ice shelf basal melting, this study was among the first to assess ice–ocean interactions and to highlight regional variations in ocean forcing. |
10.1126/science.1077987 | 103,897,277 | The possibility that the West Antarctic Ice Sheet will collapse as a consequence of ice shelf disintegration has been debated for many years. This matter is of concern because such an event would imply a sudden increase in sea level. Evidence is presented here showing drastic dynamic perturbations on former tributary g... | 10.1038/s41586-018-0171-6 | Although qualitative in nature, this paper was the first to confirm that the disintegration of the Larsen ice shelf triggered increase flow of the grounded ice upstream, by tracking glacial geomorphological features in airborne and satellite imagery. |
10.1126/science.281.5376.549 | 103,905,753 | Satellite radar interferometry observations of Pine Island Glacier, West Antarctica, reveal that the glacier hinge-line position retreated 1.2 ± 0.3 kilometers per year between 1992 and 1996, which in turn implies that the ice thinned by 3.5 ± 0.9 meters per year. The fast recession of Pine Island Glacier, predicted to... | 10.1038/s41586-018-0171-6 | As the first study to discover unstable retreat of a West Antarctic glacier in satellite data, this is a landmark paper in glaciology that has triggered widespread scientific interest in the Amundsen Sea sector. |
10.1126/science.1226481 | 102,249,320 | Warming and Melting Mass loss from the ice sheets of Greenland and Antarctica account for a large fraction of global sea-level rise. Part of this loss is because of the effects of warmer air temperatures, and another because of the rising ocean temperatures to which they are being exposed. Joughin et al. (p. 1172 ) rev... | 10.1038/s41586-018-0171-6 | This review provides a great introduction to ice–ocean interactions, and how satellite observations have informed our understanding of key processes. |
10.1029/2007jc004284 | 124,473,886 | Sea ice freeboard heights in the Weddell Sea of Antarctica are derived from the Ice, Cloud, and Land Elevation Satellite (ICESat) laser altimeter measurements, which have a unique range precision to flat surfaces of 2 cm within 70 m footprints spaced at 172 m along track. Although elevations of flat surfaces can be obt... | 10.1038/s41586-018-0171-6 | This study was the first to attempt an extensive assessment of Antarctic sea ice thickness based on satellite altimeter measurements of floe freeboard. |
10.1073/pnas.1203849109 | 123,172,170 | The global geographic distribution of subseafloor sedimentary microbes and the cause(s) of that distribution are largely unexplored. Here, we show that total microbial cell abundance in subseafloor sediment varies between sites by ca. five orders of magnitude. This variation is strongly correlated with mean sedimentati... | 10.1038/s41579-018-0046-8 | This work establishes the relationship between sedimentation rate, distance from shore and microbial biomass in subseafloor sediments and estimates that the subseafloor contains 2.9 × 10 29 cells |
10.1126/science.aaa6882 | 107,183,417 | A deep sleep in coal beds Deep below the ocean floor, microorganisms from forest soils continue to thrive. Inagaki et al. analyzed the microbial communities in several drill cores off the coast of Japan, some sampling more than 2 km below the seafloor (see the Perspective by Huber). Although cell counts decreased with ... | 10.1038/s41579-018-0046-8 | This study finds that the detection limit of living cells in anoxic subseafloor sediment is likely at depths of ~2.5 km below the seafloor |
10.1038/ismej.2013.245 | 20,041,954 | Abstract Marine sediments cover two-thirds of our planet and harbor huge numbers of living prokaryotes. Long-term survival of indigenous microorganisms within the deep subsurface is still enigmatic, as sources of organic carbon are vanishingly small. To better understand controlling factors of microbial life, we have a... | 10.1038/s41579-018-0046-8 | This study makes the discovery that exceptionally high ratios of viruses to cells exist in subseafloor sediments, which are increased in oxic sediment |
10.1073/pnas.1707525114 | 107,185,611 | The past decade of scientific ocean drilling has revealed seemingly ubiquitous, slow-growing microbial life within a range of deep biosphere habitats. Integrated Ocean Drilling Program Expedition 337 expanded these studies by successfully coring Miocene-aged coal beds 2 km below the seafloor hypothesized to be “hot spo... | 10.1038/s41579-018-0046-8 | This study performs a 2.5 year long stable isotope probing experiment from coal and shale beds 2 km below the seafloor, demonstrating that deep biosphere cells have highly variable growth rates, ranging from months to centuries |
10.1073/pnas.1614190114 | 125,317,019 | Bacterial and archaeal communities inhabiting the subsurface seabed live under strong energy limitation and have growth rates that are orders of magnitude slower than laboratory-grown cultures. It is not understood how subsurface microbial communities are assembled and whether populations undergo adaptive evolution or ... | 10.1038/s41579-018-0046-8 | This study uses SNP analysis to show that mutation rates in anoxic subseafloor sediments are extremely low |
10.1038/ismej.2015.97 | 82,893,414 | Abstract The ‘Atribacteria’ is a candidate phylum in the Bacteria recently proposed to include members of the OP9 and JS1 lineages. OP9 and JS1 are globally distributed, and in some cases abundant, in anaerobic marine sediments, geothermal environments, anaerobic digesters and reactors and petroleum reservoirs. However... | 10.1038/s41579-018-0046-8 | This genomic analysis characterizes the detailed fermentative metabolism of the ‘ Ca . Atribacteria’, showing that they ferment propionate and can synthesize and store carbohydrates in bacterial microcompartment shell proteins |
10.1111/j.1758-2229.2010.00163.x | 83,445,944 | Summary Although oligotrophic, abyssal marine sediments cover most of the sea bottom, previous investigations of microbial diversity have primarily focused on organic‐rich, anoxic sediments of continental margins. In contrast, abyssal open‐ocean sediments are oxidized and contain limiting organic substrate concentratio... | 10.1038/s41579-018-0046-8 | This paper reports the discovery that novel benthic clades of Thaumarchaeota dominate the archaeal community in oxic sediments and subsist deep below the seafloor |
10.1128/aem.01023-16 | 41,172,555 | ABSTRACT The South Pacific Gyre (SPG) possesses the lowest rates of sedimentation, surface chlorophyll concentration, and primary productivity in the global oceans. As a direct result, deep-sea sediments are thin and contain small amounts of labile organic carbon. It was recently shown that the entire SPG sediment colu... | 10.1038/s41579-018-0046-8 | This metagenomic analysis in oxic sediments suggested that remineralization of ammonia from necromass via secreted extracellular proteases supports a syntrophic relationship between ammonia oxidizing Thaumarchaeota and heterotrophic Proteobacteria |
10.1002/gbc.20030 | 122,531,629 | Previous studies have provided evidence that dark inorganic carbon fixation is an important process for the functioning of the ocean interior. However, its quantitative relevance and ecological significance in benthic deep‐sea ecosystems remain unknown. We investigated the rates of inorganic carbon fixation together wi... | 10.1038/s41579-018-0046-8 | This study provides the first experimental evidence that Thaumarchaeota perform autotrophy and mixotrophy in abyssal deep-sea oxic sediments |
10.1126/science.aad7154 | 83,494,062 | Long-term partners uncoupled Methane-munching archaea in marine sediments live closely coupled to sulfate-reducing bacteria in a syntrophic relationship. Surprisingly, however, these archaea do not necessarily need their bacterial partners to survive or grow. Scheller et al. performed stable isotope incubation experime... | 10.1038/s41579-018-0046-8 | This study provides strong experimental data showing that anaerobic methane-oxidizing archaea can use ferric iron and humic acids as TEAs, independently of syntrophy with sulfate-reducing bacteria |
10.1073/pnas.1422234112 | 42,581,188 | Viruses are key biological agents of prokaryotic mortality in the world oceans, particularly in deep-sea ecosystems where nearly all of the prokaryotic C production is transformed into organic detritus. However, the extent to which the decomposition of viral particles (i.e., organic material of viral origin) influences... | 10.1038/s41579-018-0046-8 | This study tests a large number of samples to show that extracellular enzymes hydrolyse viral capsid proteins that are released after cell lysis. Living microorganisms then use these proteins as a carbon and energy source in abyssal marine sediments |
10.1101/gad.11.3.334 | 102,939,281 | ASF/SF2 is a member of a conserved family of splicing factors known as SR proteins. These proteins, which are necessary for splicing in vitro, contain one or two amino-terminal RNP-type RNA-binding domains and an extensively phosphorylated carboxy-terminal region enriched in repeating Arg-Ser dipeptides (RS domains). P... | 10.1038/s41576-022-00550-0 | This paper provides early evidence that RBP–effector interactions can be regulated by PTMs; it demonstrates that phosphorylation of RS domains strengthens the interactions between SR proteins and U1 snRNP with relevance to pre-mRNA splicing |
10.1038/s41467-020-20191-3 | 107,316,624 | Abstract Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central RNA targets of FUS and their implications for disease remain elusive. Here, we use a unique blend of crosslinking and immunoprecipitation (CLIP) and NM... | 10.1038/s41576-022-00550-0 | This study demonstrates that the splicing activity of FUS relies on an interaction with spliceosomal RNA rather than a protein subunit, providing a rare case of protein–RNA interactions that connect an RBP and an effector |
10.1038/s41467-019-11094-z | 62,282,853 | Abstract CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene expression principally via shortening of poly(A) tails of messenger RNA or deadenylation. Here, we reconstitute a complete, recombinant human CCR4-NOT complex. Our reconstitution strategy permits strict compositional control to test m... | 10.1038/s41576-022-00550-0 | This study proposes that RBPs might, through competition with non-specifically bound mRNAs, divert the deadenylating activity of CCR4–NOT from bulk mRNA to specific mRNA targets |
10.1101/2021.08.23.457426 | 132,026,972 | SUMMARY Biomolecular condensation underlies the biogenesis of an expanding array of membraneless assemblies, including stress granules (SGs) which form under a variety of cellular stresses. Advances have been made in understanding the molecular grammar that dictates the behavior of a few key scaffold proteins that make... | 10.1038/s41576-022-00550-0 | This report documents the moonlighting activity of PABPC as a chaperone that prevents spontaneous condensation of the intrinsically disordered RBP ATXN2 |
10.1101/gad.1597707 | 40,509,834 | In eukaryotes, shortening of the 3′-poly(A) tail is the rate-limiting step in the degradation of most mRNAs, and two major mRNA deadenylase complexes—Caf1–Ccr4 and Pan2–Pan3—play central roles in this process, referred to as deadenylation. However, the molecular mechanism triggering deadenylation remains elusive. Previ... | 10.1038/s41576-022-00550-0 | Together with Gong et al. (2009), this report provides experimental support for in vivo competition between RBPs and non-RBPs for a common binding site on an effector |
10.1038/s41467-021-24705-5 | 135,269,320 | Abstract Approximately half of genetic disease-associated mutations cause aberrant splicing. However, a widely applicable therapeutic strategy to splicing diseases is yet to be developed. Here, we analyze the mechanism whereby IKBKAP- familial dysautonomia (FD) exon 20 inclusion is specifically promoted by a small mole... | 10.1038/s41576-022-00550-0 | This study provides a mechanistic insight into how RBP–effector interactions can be modulated by small synthetic molecules that affect phosphorylation with potential therapeutic effects |
10.1111/cen.14264 | 19,188,261 | Abstract Objective Severe neonatal growth hormone deficiency (GHD) can cause recurrent hypoglycaemia. Early diagnosis is warranted. The aim of the study was to analyse the GH content in screening cards of 25 affected and 281 healthy newborns. Patients and Measurements A total of 110 screening cards from ill newborns we... | 10.1038/s41574-021-00539-5 | A comprehensive and updated review of the pituitary stalk interruption syndrome for further reading |
10.1210/clinem/dgz184 | 103,016,603 | Abstract Context Congenital hypopituitarism (CH) is characterized by the presence of deficiencies in one or more of the 6 anterior pituitary (AP) hormones secreted from the 5 different specialized cell types of the AP. During human embryogenesis, hypothalamo–pituitary (HP) development is controlled by a complex spatio-... | 10.1038/s41574-021-00539-5 | A recent and up-to-date review of the molecular causes of congenital hypopituitarism |
10.1073/pnas.80.24.7496 | 83,363,142 | Salmonella typhimurium LT2 induces a set of heat-shock proteins analogous to those found previously in Escherichia coli. These are virtually the only proteins synthesized after a temperature shift from 28 degrees C to 50 degrees C. Using a two-dimensional thin-layer chromatographic system developed to resolve adenylyla... | 10.1038/s41564-022-01194-w | A classic review article describing the early discovery of Ap4A as a potential alarmone. |
10.1038/s41467-020-19166-1 | 103,301,811 | Abstract The alarmone nucleotides guanosine tetraphosphate and pentaphosphate, commonly referred to as (p)ppGpp, regulate bacterial responses to nutritional and other stresses. There is evidence for potential existence of a third alarmone, guanosine-5′-monophosphate-3′-diphosphate (pGpp), with less-clear functions. Her... | 10.1038/s41564-022-01194-w | This paper reports the Bacillus anthracis open reading frame overexpression library used in this systematic screen, and the DRaCALA method that identified IMPDH as an Ap4A target. |
10.1126/science.1225829 | 20,844,166 | Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated adaptive immune system called CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated (Cas). Jinek et al. (p. 816 , published online 28 June; see the Perspective by Brou... | 10.1038/s41586-021-03191-1 | This paper, together with reference 9, established the RNA-guided DNA cleavage activity of the Cas9 protein, providing the biochemical basis for CRISPR genome editing |
10.1126/science.1232033 | 125,274,783 | Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and plasmid DNA is targeted for cleavage by complementary CRISPR RNAs (crRNAs) bound to a CRISPR-associated endonuclease (see the Perspective by van d... | 10.1038/s41586-021-03191-1 | This paper, together with references 11–14, established the genome editing of eukaryotic cells by CRISPR–Cas9 |
10.1126/science.aad5143 | 45,358,107 | Editing can help build stronger muscles Much of the controversy surrounding the gene-editing technology called CRISPR/Cas9 centers on the ethics of germline editing of human embryos to correct disease-causing mutations. For certain disorders such as muscular dystrophy, it may be possible to achieve therapeutic benefit ... | 10.1038/s41586-021-03191-1 | This study, along with reference 50, demonstrated the feasibility of achieving therapeutically meaningful levels of genome editing in affected tissues in a mouse model of muscular dystrophy |
10.1111/j.1474-9726.2007.00281.x | 82,738,956 | Summary It is generally believed that the first organisms did not age, and that aging thus evolved at some point in the history of life. When and why this transition occurred is a fundamental question in evolutionary biology. Recent reports of aging in bacteria suggest that aging predates the emergence of eukaryotes an... | 10.1038/s41579-019-0253-y | This article presents one of the first theoretical and quantitative models for the evolution of ageing and asymmetrical reproduction in single-celled organisms |
10.1073/pnas.0708931105 | 19,188,946 | Aging, defined as a decrease in reproduction rate with age, is a fundamental characteristic of all living organisms down to bacteria. Yet we know little about the causal molecular mechanisms of aging within the in vivo context of a wild-type organism. One of the prominent markers of aging is protein aggregation, associ... | 10.1038/s41579-019-0253-y | This work shows that damaged protein aggregates are associated with reproductive senescence in E. coli |
10.1146/annurev-marine-010814-015535 | 62,597,720 | Global microbial cell numbers in the seabed exceed those in the overlying water column, yet these organisms receive less than 1% of the energy fixed as organic matter in the ocean. The microorganisms of this marine deep biosphere subsist as stable and diverse communities with extremely low energy availability. Growth i... | 10.1038/s41579-019-0253-y | This review examines patterns of microbial ageing and longevity in the deep biosphere environment |
10.1073/pnas.1614190114 | 125,317,019 | Bacterial and archaeal communities inhabiting the subsurface seabed live under strong energy limitation and have growth rates that are orders of magnitude slower than laboratory-grown cultures. It is not understood how subsurface microbial communities are assembled and whether populations undergo adaptive evolution or ... | 10.1038/s41579-019-0253-y | This study uses metagenomics and single-cell genomics to show that population genetic patterns among deep biosphere microorganisms are consistent with preadaptation to the low-energy environment, rather than ongoing adaptive evolution |
10.1126/science.aac9868 | 41,476,223 | Youthful damage limitation in stem cells Every day brings more risk of damage to stem cells, which could have consequences for the whole organism. Moore et al. observed that dividing neural stem cells in rodents establish a diffusion barrier that restricts damaged proteins to one daughter cell, leaving the other with i... | 10.1038/s41579-019-0253-y | This study demonstrates that asymmetrical allocation of damage can promote the proliferation of stem cells in the brain of a mammal |
10.1002/anie.200601872 | 82,928,314 | Abstract The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the result... | 10.1038/s41570-017-0077 | A comprehensive review of cascade reactions that showcases how different classes of cascade reaction can be used effectively to build molecular complexity. |
10.1126/science.aaf6742 | 103,836,432 | A radical route to ophiobolin rings Chemical ring-closing cascades resemble molecular yoga. One reactive site on a linear precursor can pull the whole molecule into a remarkably complex polycyclic arrangement. Cyclase enzymes rely on substantial internal scaffolding to guide this process during the biosynthesis of the ... | 10.1038/s41570-017-0077 | A study in which several radical cyclization approaches were investigated to deliver the desired cascade product. |
10.1126/science.1255677 | 29,175,597 | Cycloaddition is an essential tool in chemical synthesis. Instead of using light or heat as a driving force, marine sponges promote cycloaddition with a more versatile but poorly understood mechanism in producing pyrrole–imidazole alkaloids sceptrin, massadine, and ageliferin. Through de novo synthesis of sceptrin and ... | 10.1038/s41570-017-0077 | This paper describes efficient approaches for total synthesis inspired by biosynthetic pathways and using photoredox catalysis. |
10.1126/science.1251511 | 104,410,545 | A Dual Approach to 2 + 2 Asymmetric catalysis generally accelerates the pathway to one specific product geometry that can be manipulated by reducing the temperature to slow down competing reactions. It is more difficult to be selective in photochemical reactions, but in the [2 + 2] coupling of olefins to make four-memb... | 10.1038/s41570-017-0077 | This paper describes enantioselective photoredox [2+2] cycloadditions in which a simple ligand modification allows the diastereoselectivity of the processes to be switched. |
10.1126/scitranslmed.abe1923 | 130,276,135 | Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs. | 10.1038/s41582-022-00653-6 | This study was the first to elucidate a mechanism of NPC injury in sporadic ALS, identify a cause of loss of nuclear TDP43 function in human neurons, and identify a candidate therapeutic strategy to repair NPC injury and subsequent TDP43 dysfunction |
10.1126/science.aad2033 | 102,290,336 | Location, location, location Aggregates of certain disease-associated proteins are involved in neurodegeneration. Woerner et al. now show that the exact location of these aggregates in the cell may be the key to their pathology (see the Perspective by Da Cruz and Cleveland). An artificial aggregate-prone protein caused... | 10.1038/s41582-022-00653-6 | This study provides evidence that cytoplasmic aggregation can impair nucleocytoplasmic transport |
10.1126/science.1217421 | 20,371,249 | Individual components of rat brain nuclear pores can be almost as old as the animal itself. | 10.1038/s41582-022-00653-6 | This study identified a subset of nucleoporins as some of the longest-lived proteins |
10.1159/000446581 | 6,513,764 | <b><i>Objective:</i></b> Gene scores are often used to model the combined effects of genetic variants. When variants are in linkage disequilibrium, it is common to prune all variants except the most strongly associated. This avoids duplicating information but discards information when variants h... | 10.1038/s41576-020-0224-1 | This study shows that the accuracy of a PRS is affected by the modelling of linkage disequilibrium between SNPs |
10.1093/jamia/ocv202 | 41,540,630 | Abstract Objective Health care generated data have become an important source for clinical and genomic research. Often, investigators create and iteratively refine phenotype algorithms to achieve high positive predictive values (PPVs) or sensitivity, thereby identifying valid cases and controls. These algorithms achiev... | 10.1038/s41576-020-0224-1 | This paper discusses PheKB, which contains a wide range of phenotyping algorithms that can automatically extract phenotypes from EHR data |
10.1002/gepi.22083 | 107,254,000 | ABSTRACT Methods for genetic risk prediction have been widely investigated in recent years. However, most available training data involves European samples, and it is currently unclear how to accurately predict disease risk in other populations. Previous studies have used either training data from European samples in l... | 10.1038/s41576-020-0224-1 | This study uses data from multiple populations to derive a more generalizable PRS for T2DM |
10.1126/science.1070884 | 41,679,441 | Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mi... | 10.1038/s41577-019-0225-5 | This study (and also reference 164) reports the first direct interaction between a viral ligand and an activating NK cell receptor |
10.1126/science.287.5455.1031 | 123,838,104 | The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived from MHC class I molecules. The same peptide is present in the leader seq... | 10.1038/s41577-019-0225-5 | This study finds that the leader sequence of gpUL40 binds HLA-E and upregulates its surface expression, thereby protecting infected cells from NK cell attack |
10.1084/jem.20022059 | 109,133,218 | The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I–related ligands, including the MIC and ULBP proteins. Infection, stress, or transformation can induce NKG2D ligand expression, resulting in effector cell... | 10.1038/s41577-019-0225-5 | Collectively, this study and references 120 and 123 highlight that both HCMV and MCMV have evolved molecules that interfere with surface expression of NKG2D ligands |
10.1084/jem.20042558 | 109,116,344 | Expression of killer cell Ig-like receptors (KIRs) diversifies human natural killer cell populations and T cell subpopulations. Whereas the major histocompatibility complex class I binding functions of inhibitory KIR are known, specificities for the activating receptors have resisted analysis. To understand better acti... | 10.1038/s41577-019-0225-5 | This study investigates the evolutionary history of KIRs and Ly49 receptors and proposes a model in which the activating receptors evolved more recently from their inhibitory counterparts in response to selective pressure induced by pathogens |
10.1084/jem.20080954 | 41,679,429 | Natural killer (NK) cells are crucial in resistance to certain viral infections, but the mechanisms used to recognize infected cells remain largely unknown. Here, we show that the activating Ly49P receptor recognizes cells infected with mouse cytomegalovirus (MCMV) by a process that requires the presence of H2-Dk and t... | 10.1038/s41577-019-0225-5 | This study and references 165 and 166 show that activating Ly49 receptors can recognize infected cells via a novel mechanism that is dependent on certain MHC-I allotypes |
10.1111/j.1472-4642.2010.00645.x | 124,981,295 | Abstract Aim The study of biological invasions has long considered species invasiveness and community invasibility as separate questions. Only recently, there is an increasing recognition that integrating these two questions offers new insights into the mechanisms of biological invasions. This recognition has renewed t... | 10.1038/s41477-022-01215-w | A Review article that presents inconsistent outcomes of Darwin’s naturalization conundrum tests. |
10.1046/j.1472-4642.2000.00083.x | 125,216,733 | Abstract. Much confusion exists in the English‐language literature on plant invasions concerning the terms ‘naturalized’ and ‘invasive’ and their associated concepts. Several authors have used these terms in proposing schemes for conceptualizing the sequence of events from introduction to invasion, but often imprecisel... | 10.1038/s41477-022-01215-w | A Review article that conceptualizes the naturalization and invasion process. |
10.1111/ecog.05669 | 134,342,464 | Biological invasions are one of the most defining features of the Anthropocene. Most studies on biological invasions focus on the later stages of the invasion process, that is after species have already become naturalized. It is frequently overlooked, however, that patterns in origin, phylogeny and traits of naturalize... | 10.1038/s41477-022-01215-w | This paper reports on the implications of ignoring alien species’ introduction bias. |
10.5194/tc-12-521-2018 | 20,346,660 | Abstract. Ice discharge from large ice sheets plays a direct role in determining rates of sea-level rise. We map present-day Antarctic-wide surface velocities using Landsat 7 and 8 imagery spanning 2013–2015 and compare to earlier estimates derived from synthetic aperture radar, revealing heterogeneous changes in ice f... | 10.1038/s41586-022-04946-0 | Uses ice-surface-velocity datasets and a SMB model to suggest that, overall, ice discharge from glaciers draining the EAIS was remarkably stable between around 2008 and 2013/2015, whereas those in West Antarctica increased |
10.1073/pnas.1812883116 | 83,375,171 | We use updated drainage inventory, ice thickness, and ice velocity data to calculate the grounding line ice discharge of 176 basins draining the Antarctic Ice Sheet from 1979 to 2017. We compare the results with a surface mass balance model to deduce the ice sheet mass balance. The total mass loss increased from 40 ± 9... | 10.1038/s41586-022-04946-0 | Uses revised drainage inventory, ice thickness and ice-velocity data, together with a SMB model, to calculate Antarctic Ice Sheet mass balance (1979–2017) and suggest that East Antarctica was an important participant in mass loss |
10.1029/2020gl090961 | 97,304,326 | Abstract The Antarctic Ice Sheet (AIS) is a major contributor to current global sea‐level change and the largest potential source of future sea‐level change. Variability in AIS mass balance on a wide range of spatiotemporal scales obscures secular trends, increasing the uncertainty of projections. We introduce a novel ... | 10.1038/s41586-022-04946-0 | Introduces a new approach for analysing satellite gravimetry observations to estimate time-varying mass-change rates in Antarctica and finds a continuously accelerating trend of mass loss in Wilkes Land, East Antarctica, over the past two decades |
10.1126/science.1110662 | 27,511,714 | Satellite radar altimetry measurements indicate that the East Antarctic ice-sheet interior north of 81.6°S increased in mass by 45 ± 7 billion metric tons per year from 1992 to 2003. Comparisons with contemporaneous meteorological model snowfall estimates suggest that the gain in mass was associated with increased prec... | 10.1038/s41586-022-04946-0 | One of the earliest studies to use satellite radar altimetry to show that sea-level rise was mitigated by snowfall-driven growth of the EAIS (1992–2003) |
10.1126/sciadv.1601610 | 103,897,809 | Mass loss from the West Antarctic ice shelves and glaciers has been linked to basal melt by ocean heat flux. The Totten Ice Shelf in East Antarctica, which buttresses a marine-based ice sheet with a volume equivalent to at least 3.5 m of global sea-level rise, also experiences rapid basal melt, but the role of ocean fo... | 10.1038/s41586-022-04946-0 | Presents observations from the calving front of Totten Glacier, East Antarctica, that confirm that warm water enters the ice-shelf cavity through a deep channel, driving high basal-melt rates |
10.5194/tc-14-3033-2020 | 122,969,992 | Abstract. Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in response to different climate scenarios and assess the mass loss that would contribute to future sea level rise. However, there is currently no consensus on estimates of the future mass balance of the ice sheet, p... | 10.1038/s41586-022-04946-0 | Presents an intercomparison of ice-flow simulations from 13 international groups and finds that East Antarctic mass change (2015–2100) varies from −6.1 cm to +8.3 cm in the simulations, with a marked increase in SMB outweighing the increased ice discharge under most RCP8.5 projections |
10.1083/jcb.201605110 | 29,203,254 | In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by d... | 10.1038/s41580-020-00324-8 | This paper represents the first report of a ferroptosis-like cell death process in plants |
10.1101/gad.334219.119 | 41,550,618 | MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less information available about p53-independent roles of MDMX or the MDM2–... | 10.1038/s41580-020-00324-8 | This paper reports that the MDM2–MDMX complex facilitates ferroptosis by suppressing PPARα-mediated induction of FSP1 and subsequent reduction in ubiquinone levels |
10.1161/circresaha.113.279984 | 20,453,064 | Rationale: Growing evidence indicates that oxidative stress contributes markedly to endothelial dysfunction. The selenoenzyme glutathione peroxidase 4 (Gpx4) is an intracellular antioxidant enzyme important for the protection of membranes by its unique activity to reduce complex hydroperoxides in membrane bilayers and ... | 10.1038/s41580-020-00324-8 | This paper reports that phenotypes induced by the loss of the key ferroptosis regulator GPX4 can be masked by dietary vitamin E in certain tissues in mice |
10.1126/science.1126100 | 2,694,818 | Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with genealogy data, we identified germline mutations in the aryl hydrocarbon receptor interacting protein ( AIP ) gene in individuals with pituitary adenoma predispos... | 10.1038/s41574-018-0114-1 | This study describes the discovery of AIP mutations as an inherited cause of pituitary adenomas. |
10.1530/erc-16-0082 | 110,034,637 | Somatic mosaicism has been implicated as a causative mechanism in a number of genetic and genomic disorders. X-linked acrogigantism (XLAG) syndrome is a recently characterized genomic form of pediatric gigantism due to aggressive pituitary tumors that is caused by submicroscopic chromosome Xq26.3 duplications that incl... | 10.1038/s41574-018-0114-1 | This study describes how X-LAG syndrome can be caused by mosaicism for chromosome Xq26.3 duplications and can be detected in the screening of patient cohorts using digital PCR. |
10.1126/science.286.5446.1946 | 82,392,050 | Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein–2 ( BMP-2 )... | 10.1038/s41577-018-0094-3 | This is a unique report that shows that statins promote bone formation by increasing BMP2 gene expression and are therefore a potential treatment for osteoporosis |
10.1084/jem.20040061 | 39,303,088 | Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft–associated receptors, a process that might be linked to Rho guanosine triphosphatase (GTPase) activation. Rho GTPase activity can be negatively regulated by statins, a family of drugs used to treat hypercholesterolem... | 10.1038/s41577-018-0094-3 | This is an important report that shows direct inhibition of HIV-1 by statins in chronically infected patients |
10.1038/srep16407 | 81,690,966 | Abstract The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in discovery of novel antibacterial agents has created a global public health crisis. Repurposing existing drugs presents an alternative strategy to potentially expedite the discovery of new antimicrobial drugs. The pre... | 10.1038/s41577-018-0094-3 | This is an important report showing that topical application of statin reduces Staphylococcus spp. biofilms and the growth of drug-resistant strains in skin lesions |
10.1161/circgenetics.113.000099 | 82,353,886 | Background— A barrier to statin therapy is myopathy associated with elevated systemic drug exposure. Our objective was to examine the association between clinical and pharmacogenetic variables and statin concentrations in patients. Methods and Results— In total, 299 patients taking atorvastatin or rosuvastatin were pro... | 10.1038/s41577-018-0094-3 | References 136, 137 and 138 identify several polymorphisms associated with the individual variability in responses to statin therapy |
10.1002/ana.20493 | 82,451,837 | Abstract Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It is being debated whether this reflects diminished demand because of advanced neurodegeneration or that cerebral hypoperfusion contributes to dementia. We examined the relation of CBF velocity as measured with transcranial ... | 10.1038/s41593-018-0234-x | This large population-based study showed that diminished cerebral blood flow precedes cognitive decline and hippocampal atrophy |
10.1073/pnas.97.17.9735 | 82,899,221 | Peptides derived from proteolytic processing of the β-amyloid precursor protein (APP), including the amyloid-β peptide (Aβ), play a critical role in the pathogenesis of Alzheimer's dementia. We report that transgenic mice overexpressing APP and Aβ have a profound attenuation in the increase in neocortical blood flow el... | 10.1038/s41593-018-0234-x | This paper was the first to demonstrate altered neurovascular coupling by amyloid-β |
10.1002/ana.24406 | 83,506,780 | Objective Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there is evidence for impairments of the cerebral vasculature as well as the bl... | 10.1038/s41593-018-0234-x | Blood–brain barrier leakage and cerebrovascular dysfunction in Huntington’s disease investigated by neuroimaging and postmortem tissue analysis in human subjects and further corroborated in a mouse model of Huntington’s disease |
10.1126/scitranslmed.aaf8020 | 83,296,497 | A method to visualize MMPs reveals penetration of the blood-brain barrier by leukocytes early in multiple sclerosis. | 10.1038/s41593-018-0234-x | The authors developed an important, novel approach to image initial leukocyte penetration of the blood–brain barrier in multiple sclerosis patients and animal models |
10.1038/s41467-017-00769-0 | 80,282,264 | Abstract During ageing, microglia acquire a phenotype that may negatively affect brain function. Here we show that ageing microglial phenotype is largely imposed by interferon type I (IFN-I) chronically present in aged brain milieu. Overexpression of IFN-β in the CNS of adult wild-type mice, but not of mice lacking IFN... | 10.1038/s41593-022-01105-6 | A research paper showing that microglia acquire a pro-inflammatory profile in aging |
10.1016/j.jalz.2016.01.012 | 38,396,742 | Abstract As the discovery of the Alzheimer's disease (AD) genes, APP , PSEN1 , and PSEN2 , in families with autosomal dominant early‐onset AD (EOAD), gene discovery in familial EOAD came more or less to a standstill. Only 5% of EOAD patients are carrying a pathogenic mutation in one of the AD genes or a apolipoprotein ... | 10.1038/s41582-020-00416-1 | This paper lays out the known mutations in APP PSEN1 and PSEN2 and their location in relation to functional domains in great detail |
10.1126/sciadv.aav7769 | 103,897,758 | Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes present an attractive synthetic dependency in cancers. However, the impact that these genetic events have on metabolic processes, which are also dependent on nutrient availability and other environmental factors, is unknown. As a pr... | 10.1038/s41568-019-0187-8 | This study quantifies the roles of MTAP status and nutrient availability in methionine metabolism |
10.1101/286054 | 32,903,556 | SUMMARY Cancer cell survival upon cytotoxic drug exposure leads to changes in cell identity, dictated by the epigenome. Several metabolites serve as substrates or co-factors to chromatin-modifying enzymes, suggesting that metabolic changes can underlie change in cell fate. Here, we show that progression of triple-negat... | 10.1038/s41568-019-0187-8 | This study defines a role for methionine metabolism in mediating chemotherapy resistance |
10.1038/s41467-018-04426-y | 102,256,445 | Abstract Nutrition and metabolism are known to influence chromatin biology and epigenetics through post-translational modifications, yet how this interaction influences genomic architecture and connects to gene expression is unknown. Here we consider, as a model, the metabolically-driven dynamics of H3K4me3, a histone ... | 10.1038/s41568-019-0187-8 | This paper investigates how methionine levels link to specific features of the genomic architecture |
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