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PMC7766849 | core_pubmed_pmc | Pharmacokinetic Characterization and External Evaluation of a Quantitative Framework of Sublingual Buprenorphine in Patients with an Opioid Disorder in Puerto Rico | Pharmacokinetic Characterization and External Evaluation of a Quantitative Framework of Sublingual Buprenorphine in Patients with an Opioid Disorder in Puerto Rico Abstract Background: The aim of this analysis was to characterize the pharmacokinetics (PK) of sublingual buprenorphine (BUP) and its metabolites (buprenorp... |
PMC5683787 | core_pubmed_pmc | Role of 3-monthly long-acting injectable paliperidone in the maintenance of schizophrenia | Role of 3-monthly long-acting injectable paliperidone in the maintenance of schizophrenia Abstract Aims Paliperidone palmitate 3-month (PP3M) represents a new long-acting injectable antipsychotic therapeutic option. This review aims: 1) to summarize available data relating to efficacy, safety, tolerability and costs of... |
PMC11452728 | core_pubmed_pmc | Pharmacokinetics of pulmonary indacaterol in rat lung using molecular imprinting solid-phase extraction coupled with RP-UPLC | Pharmacokinetics of pulmonary indacaterol in rat lung using molecular imprinting solid-phase extraction coupled with RP-UPLC Abstract Abstract Indacaterol, a β 2 agonist prescribed for long-term management of patients with chronic obstructive pulmonary disease and asthma. In this study the first MISPE cartridges was de... |
PMC6817585 | core_pubmed_pmc | Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract | Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract Abstract Abstract An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuci... |
PMC8290316 | core_pubmed_pmc | A Promising Anticancer Agent Dimethoxycurcumin: Aspects of Pharmacokinetics, Efficacy, Mechanism, and Nanoformulation for Drug Delivery | A Promising Anticancer Agent Dimethoxycurcumin: Aspects of Pharmacokinetics, Efficacy, Mechanism, and Nanoformulation for Drug Delivery Abstract Abstract Curcumin is a well-known anticancer natural product with various significant bioactivities that has been well documented, but its widespread use is mainly hindered by... |
PMC11646931 | core_pubmed_pmc | Application of physiologically‐based pharmacokinetic modeling to inform dosing decisions for geriatric patients | Application of physiologically‐based pharmacokinetic modeling to inform dosing decisions for geriatric patients Modeling HOW CAN PBPK MODELS BE EXTRAPOLATED TO GERIATRIC PATIENTS WITH MULTIPLE COMORBIDITIES? Aging is often accompanied by changes in the anatomy and physiology of multiple tissues and organs. Consideratio... |
PMC4559582 | core_pubmed_pmc | Jejunal Infusion of Levodopa–Carbidopa Intestinal Gel Versus Oral Administration of Levodopa–Carbidopa Tablets in Japanese Subjects with Advanced Parkinson’s Disease: Pharmacokinetics and Pilot Efficacy and Safety | Jejunal Infusion of Levodopa–Carbidopa Intestinal Gel Versus Oral Administration of Levodopa–Carbidopa Tablets in Japanese Subjects with Advanced Parkinson’s Disease: Pharmacokinetics and Pilot Efficacy and Safety Abstract Background and Objective Oral levodopa-carbidopa (LC-oral) treatment in advanced Parkinson’s dise... |
PMC11040043 | core_pubmed_pmc | Petroselinum crispum L ., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities : In vitro and in silico predictions | Petroselinum crispum L ., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities : In vitro and in silico predictions Abstract Abstract This exploratory study aims to identify the volatile compounds in PC-Eo ( Petroselinum crispum L. essential oil) and evaluate its antioxidant a... |
PMC6369847 | core_pubmed_pmc | Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy | Combined administration of PTX and S-HM-3 in TPGS/Solutol micelle system for oncotarget therapy Abstract Background S-HM-3 is a tumor angiogenesis inhibitor with short half-life (25 min). In this present, TPGS/Solutol polymeric micelles was prepared to load together insoluble paclitaxel (PTX) and soluble S-HM-3, expect... |
PMC5484109 | core_pubmed_pmc | A Study of 11-[ 3 H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats | A Study of 11-[ 3 H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats Abstract Tetrodotoxin (TTX) is a powerful sodium channel blocker that in low doses can safely relieve severe pain. Studying the absorption, distribution, metabolism and excretion (ADME) of TTX is cha... |
PMC11434395 | core_pubmed_pmc | A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin | A Multi-Spectroscopic and Molecular Docking Analysis of the Biophysical Interaction between Food Polyphenols, Urolithins, and Human Serum Albumin Abstract Secondary polyphenol metabolites, urolithins (UROs), have anti-oxidative, anti-inflammatory, and antidiabetic properties. Therefore, their biological activity relies... |
PMC10671567 | core_pubmed_pmc | Evaluation of Biological Equivalence for Generic Tulathromycin Injections in Cattle | Evaluation of Biological Equivalence for Generic Tulathromycin Injections in Cattle Abstract Abstract The recent expiration of patents for the antibiotic tulathromycin has led to a significant increase in the number of generic tulathromycin products (GTPs) available. This study aims to evaluate the bioequivalence of fo... |
PMC10417861 | core_pubmed_pmc | Alternate Antimicrobial Therapies and Their Companion Tests | Alternate Antimicrobial Therapies and Their Companion Tests Abstract Abstract New antimicrobial approaches are essential to counter antimicrobial resistance. The drug development pipeline is exhausted with the emergence of resistance, resulting in unsuccessful trials. The lack of an effective drug developed from the co... |
PMC9706311 | core_pubmed_pmc | Prediction of total and renal clearance of renally secreted drugs in neonates and infants (≤3 months of age) | Prediction of total and renal clearance of renally secreted drugs in neonates and infants (≤3 months of age) Abstract Abstract Background: Renal excretion is a major route of elimination for many drugs. Renal clearance is the sum of three processes: glomerular filtration, tubular secretion, and tubular re-absorption. T... |
PMC5062546 | core_pubmed_pmc | Nicotinamide riboside is uniquely and orally bioavailable in mice and humans | Nicotinamide riboside is uniquely and orally bioavailable in mice and humans Abstract Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood NAD + metabolism in humans. We report that human blood NAD + can rise as much as 2.... |
PMC5048094 | core_pubmed_pmc | Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model | Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model Abstract Abstract The purpose of the present study was to evaluate the neuroprotective efficacy of optimized thymoquinone loaded PLGA-chitosan nanoparticles delivered via nose to brain route in the rod... |
PMC7406636 | core_pubmed_pmc | In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study | In vivo and in silico characterization of apocynin in reducing organ oxidative stress: A pharmacokinetic and pharmacodynamic study Abstract Abstract Apocynin has been widely used in vivo as a Nox2‐contaninig nicotinamide adenine dinucleotide phosphate oxidase inhibitor. However, its time‐dependent tissue distribution a... |
PMC5601395 | core_pubmed_pmc | Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach | Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach Abstract Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase,... |
PMC3620775 | core_pubmed_pmc | Invasive Fungal Infections in Infants—Focus on Anidulafungin | Invasive Fungal Infections in Infants—Focus on Anidulafungin Abstract Introduction: Invasive fungal infection in pediatric intensive care units (PICU) is a rising challenge. Candida species are the most common microorganisms in these infections. Due to growing resistance against fluconazole, echinocandins are being use... |
PMC9952805 | core_pubmed_pmc | Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age | Adequacy of the 10 mg/kg Daily Dose of Antituberculosis Drug Isoniazid in Infants under 6 Months of Age Abstract In 2010, the WHO recommended an increase in the daily doses of first-line anti-tuberculosis medicines in children. We aim to characterize the pharmacokinetics of the once-daily isoniazid (INH) dose at 10 mg/... |
PMC6875705 | core_pubmed_pmc | Enhancing the Quality of Rivaroxaban Exposure Estimates Using Prothrombin Time in the Absence of Pharmacokinetic Sampling | Enhancing the Quality of Rivaroxaban Exposure Estimates Using Prothrombin Time in the Absence of Pharmacokinetic Sampling Abstract Prothrombin time ( PT ) is a measure of coagulation status and was assessed in the majority of patients in the rivaroxaban phase II and III clinical trials as a pharmacodynamic marker. In t... |
PMC10180615 | core_pubmed_pmc | Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors | Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors Abstract Abstract Background Report of a Phase 1 dose-escalation study of OBI-3424 monotherapy in patients with advanced solid tumors ( NCT03592264 ). Methods A c... |
PMC12011786 | core_pubmed_pmc | Pharmacokinetics and stability of methoxyflavones from Kaempferia parviflora in Thai native roosters | Pharmacokinetics and stability of methoxyflavones from Kaempferia parviflora in Thai native roosters Abstract Abstract Introduction The present study aimed to characterize the pharmacokinetics and stability of methoxyflavones derived from Kaempferia parviflora (KP) in Thai native roosters after oral administration of a... |
PMC9969340 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants | Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants Abstract Abstract The aim of this study was to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GSK3772847, compared with placebo administered subcutaneously (SC... |
PMC9860417 | core_pubmed_pmc | Bioequivalence studies of cetirizine tablets using the urine excretion data of healthy Ghanaian male volunteers | Bioequivalence studies of cetirizine tablets using the urine excretion data of healthy Ghanaian male volunteers Abstract Abstract Background In the wake of economic challenges, the role of generic medicines has become crucial in meeting the healthcare needs of people. Their use, however, can only be guaranteed if estab... |
PMC4804608 | core_pubmed_pmc | Male patients require higher optimal effect-site concentrations of propofol during i-gel insertion with dexmedetomidine 0.5 μg/kg | Male patients require higher optimal effect-site concentrations of propofol during i-gel insertion with dexmedetomidine 0.5 μg/kg Abstract Abstract Background The pharmacokinetics and pharmacodynamics of an anesthetic drug may be influenced by gender. The purpose of this study was to compare effect-site half maximal ef... |
PMC11700851 | core_pubmed_pmc | A specific and adaptable approach to track CD206 + macrophages by molecular MRI and fluorescence imaging | A specific and adaptable approach to track CD206 + macrophages by molecular MRI and fluorescence imaging Abstract Rationale: The mannose receptor (CD206, expressed by the gene Mrc1 ) is a surface marker overexpressed by anti-inflammatory and pro-tumoral macrophages. As such, CD206 + macrophages play key roles in the im... |
PMC6804443 | core_pubmed_pmc | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care Abstract Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding XueBiJing, a five-herb medicine, t... |
PMC3230567 | core_pubmed_pmc | Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process | Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process Abstract Abstract Background The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion o... |
PMC8055359 | core_pubmed_pmc | Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats | Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats Abstract Abstract Background A method for the determination of selinexor by UPLC-MS/MS was established to study the effect of posaconazole on the pharmacokinetics of selinexor in rats... |
PMC11652457 | core_pubmed_pmc | Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Pegcetacoplan in Patients with Paroxysmal Nocturnal Hemoglobinuria | Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Pegcetacoplan in Patients with Paroxysmal Nocturnal Hemoglobinuria Abstract Background and Objective Paroxysmal nocturnal hemoglobinuria is a rare blood disorder characterized by life-threatening hemolysis and thrombosis. Complement C5 inhibitor... |
PMC12064609 | core_pubmed_pmc | Population Pharmacokinetics and Pharmacodynamics of Fepixnebart (LY3016859) and Epiregulin in Patients with Chronic Pain | Population Pharmacokinetics and Pharmacodynamics of Fepixnebart (LY3016859) and Epiregulin in Patients with Chronic Pain Abstract Abstract Background and Objective Fepixnebart (LY3016859), a humanized immunoglobulin G4 monoclonal antibody with high binding affinity to epiregulin and tumor growth factor-α, is being deve... |
PMC6796206 | core_pubmed_pmc | A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis | A randomized, phase IIa study to assess the systemic exposure of triamcinolone acetonide following injection of extended-release triamcinolone acetonide or traditional triamcinolone acetonide into both knees of patients with bilateral knee osteoarthritis Abstract Background: Intra-articular corticosteroids are commonly... |
PMC6800884 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid–aspirin complex: results of a randomized, crossover, bioequivalence study | Pharmacokinetic/pharmacodynamic assessment of a novel, pharmaceutical lipid–aspirin complex: results of a randomized, crossover, bioequivalence study Abstract Aspirin (acetylsalicylic acid, ASA) can lead to gastrointestinal mucosal injury through disruption of its protective phospholipid bilayer. A liquid formulation o... |
PMC9326877 | core_pubmed_pmc | Excipient-drug pharmacokinetic interactions: Effect of disintegrants on efflux across excised pig intestinal tissues | Excipient-drug pharmacokinetic interactions: Effect of disintegrants on efflux across excised pig intestinal tissues Abstract Abstract Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmac... |
PMC12473659 | core_pubmed_pmc | Formulation, Optimization, and Evaluation of Transferosomes Co-Loaded with Methotrexate and Sorafenib for Anti-Arthritic Activity | Formulation, Optimization, and Evaluation of Transferosomes Co-Loaded with Methotrexate and Sorafenib for Anti-Arthritic Activity Abstract Abstract Purpose: This study was designed to develop a nanoparticle-based methotrexate (MTX) and sorafenib (SRF)-loaded transferosome (MTX-SRF-TFS) for effective management of arthr... |
PMC10477830 | core_pubmed_pmc | AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors | AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors Abstract Abstract HER3 is a unique member of the EGFR family of tyrosine kinases, which is broadly expressed in several cancers, including breast, lung, pancreatic, colorecta... |
PMC11270968 | core_pubmed_pmc | Antiplasmodial potential of isolated xanthones from Mesua ferrea Linn. roots: an in vitro and in silico molecular docking and pharmacokinetics study | Antiplasmodial potential of isolated xanthones from Mesua ferrea Linn. roots: an in vitro and in silico molecular docking and pharmacokinetics study Abstract Background Malaria is a major global health concern, particularly in tropical and subtropical countries. With growing resistance to first-line treatment with arte... |
PMC11597828 | core_pubmed_pmc | FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes | FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes Abstract Background: It has been demonstrated that the concept of infinite absorption time, associated with the absorption rate constant, which drives... |
PMC9656319 | core_pubmed_pmc | Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model | Pharmacokinetics and Tissue Distribution of Coumarins from Tagetes lucida in an LPS-Induced Neuroinflammation Model Abstract Tagetes lucida has been widely used as a folk remedy in illnesses associated with the central nervous system and inflammatory ailments. Among the chemical compounds that stand out in the plant ag... |
PMC8979760 | core_pubmed_pmc | Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19 | Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19 Abstract Pediatric patients with coronavirus disease 2019 (COVID-19) are increasing, and severe cases such as multisystem inflammatory syndrome are being reported. Nafamostat, a repur... |
PMC8115178 | core_pubmed_pmc | The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study | The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study Abstract JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of fatty acid a... |
PMC8415660 | core_pubmed_pmc | Safe and appropriate use of diclofenac in chronic kidney disease: An Indian perspective | Safe and appropriate use of diclofenac in chronic kidney disease: An Indian perspective Abstract Abstract Pain is most common symptom associated with progressive disorder, chronic kidney disease (CKD), and is usually undertreated during the early stages of CKD. So, present review was conducted to evaluate the challenge... |
PMC12753254 | core_pubmed_pmc | Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline | Glycyrrhizic acid-loaded biomimetic hybrid liposomes targeting inflammatory cascades and PD-1/PD-L1 pathway to reverse neuroinflammation-driven cognitive decline Abstract Neuroinflammation is a key pathogenic process in multiple central nervous system (CNS) disorders. It can lead to neuronal injury and cognitive declin... |
PMC7982780 | core_pubmed_pmc | Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients | Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients Abstract Abstract Aim The study was aimed to understand the underlying causes for the differences in propranolol pharmacokinetics (PK) between healthy ... |
PMC12828649 | core_pubmed_pmc | Engineering combination nanomedicines to overcome cancer resistance | Engineering combination nanomedicines to overcome cancer resistance Abstract Combination nanomedicine enables the coordinated delivery of multiple therapeutic agents using engineered nanosystems to address tumor heterogeneity, multidrug resistance, and systemic toxicity. Despite extensive preclinical progress, many com... |
PMC5010551 | core_pubmed_pmc | JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers | JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers Abstract Abstract Background Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that JN... |
PMC12670405 | core_pubmed_pmc | Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma | Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma Abstract Aurora kinase A (AURKA) is an established oncogenic factor and therapeutic target in neuroblastoma due to its roles in mitosis and stability of the MYCN protein. We previously identified SK2188 as a h... |
PMC12307862 | core_pubmed_pmc | LC-MS/MS quantification of omadacycline in human plasma for therapeutic drug monitoring: method development and clinical application | LC-MS/MS quantification of omadacycline in human plasma for therapeutic drug monitoring: method development and clinical application Abstract Omadacycline, a third-generation tetracycline antibiotic, exhibits time-dependent pharmacokinetics. The ratio of the 24-hour area under the concentration-time curve to minimum in... |
PMC8948694 | core_pubmed_pmc | Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing | Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing Abstract We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling ... |
PMC7765153 | core_pubmed_pmc | Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices | Analytical Methods for the Detection and Quantification of ADCs in Biological Matrices Abstract Understanding pharmacokinetics and biodistribution of antibody–drug conjugates (ADCs) is a one of the critical steps enabling their successful development and optimization. Their complex structure combining large and small m... |
PMC8370226 | core_pubmed_pmc | Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study | Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study Abstract ABSTRACT We assessed the pharmacokinetics and safety of XAV-19, a swine glyco-humanized polyclonal antibod... |
PMC10460718 | core_pubmed_pmc | Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia | Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia Abstract Population pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic (popPK/PD) relationship between bempedoic acid... |
PMC9755210 | core_pubmed_pmc | Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes | Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes Abstract Abstract Objective: This study aims to develop a combined population pharmacokinetic (PPK) model ... |
PMC9355628 | core_pubmed_pmc | Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste | Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste Abstract Abstract Hemp based cannabinoids have gained popularity in veterinary medicine due to the potential to treat pain, seizure disorders and dermatological maladies in dogs. Cat owners are also using ... |
PMC12479386 | core_pubmed_pmc | Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of ( E )‐ N ’‐Benzylidenepyrazine‐2‐Carbohydrazides and their Derivatives | Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of ( E )‐ N ’‐Benzylidenepyrazine‐2‐Carbohydrazides and their Derivatives Abstract Abstract A series of 33 ( E )‐ N ’‐benzylidenepyrazine‐2‐carbohydrazides and their derivatives were synthesized and tested for biological activity. Benzylide... |
PMC11513594 | core_pubmed_pmc | UPLC-MS/MS analysis of axitinib and pharmacokinetic application in beagle dogs | UPLC-MS/MS analysis of axitinib and pharmacokinetic application in beagle dogs Abstract Abstract Objective To develop a method for determining the concentration of axitinib in beagle dog plasma and utilize this method to investigate the pharmacokinetics of orally administered axitinib in beagle dogs. Methods Plasma sam... |
PMC12741140 | core_pubmed_pmc | Conceptual quantitative systems pharmacology framework for supporting clinical trial design in organ-specific autoimmune and rare diseases | Conceptual quantitative systems pharmacology framework for supporting clinical trial design in organ-specific autoimmune and rare diseases Abstract Organ-specific autoimmune and rare inflammatory diseases present significant challenges for clinical trial design due to profound patient heterogeneity, small population si... |
PMC11771541 | core_pubmed_pmc | Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study | Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study Abstract Abstract The novel antimalarial ganaplacide combined with lumefan... |
PMC7308650 | core_pubmed_pmc | Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice | Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice Abstract The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determi... |
PMC5225497 | core_pubmed_pmc | Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach | Herb pair Danggui-Honghua: mechanisms underlying blood stasis syndrome by system pharmacology approach Abstract Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis syndrome (BSS) in China, one of the most common clinical pathological syndromes in traditional Chinese medicine (TCM). However,... |
PMC9893898 | core_pubmed_pmc | Pharmacodynamic appraisal of wound-healing herbs of Sushruta Samhita | Pharmacodynamic appraisal of wound-healing herbs of Sushruta Samhita Abstract Abstract Background: In Sushruta Samhita , various medicinal plants as single and compound formulations having Vrana-Shodhana (wound cleansing) and Vrana-Ropana (wound healing) potential are enumerated. There are no published data available o... |
PMC11364845 | core_pubmed_pmc | Biodistribution of PET radiotracers in tumor-bearing TRAMP mice administered by retroorbital or jugular vein injections | Biodistribution of PET radiotracers in tumor-bearing TRAMP mice administered by retroorbital or jugular vein injections Abstract Abstract Nuclear medicine is an important tool for use in molecular imaging of important biological processes. Methods for intravenous delivery of radiotracers remains a challenge, with tail ... |
PMC5397408 | core_pubmed_pmc | Pharmacokinetic Properties of Three Forms of Vaginal Progesterone Administered in Either Single Or Multiple Dose Regimen in Healthy Post-menopausal Chinese Women | Pharmacokinetic Properties of Three Forms of Vaginal Progesterone Administered in Either Single Or Multiple Dose Regimen in Healthy Post-menopausal Chinese Women Abstract Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese s... |
PMC9316831 | core_pubmed_pmc | Evaluation of Acute and Subacute Toxicity and LC-MS/MS Compositional Alkaloid Determination of the Hydroethanolic Extract of Dysphania ambrosioides (L.) Mosyakin and Clemants Flowers | Evaluation of Acute and Subacute Toxicity and LC-MS/MS Compositional Alkaloid Determination of the Hydroethanolic Extract of Dysphania ambrosioides (L.) Mosyakin and Clemants Flowers Abstract Dysphania ambrosioides (L.) Mosyakin and Clemants is a medicinal plant that has traditionally been used to cure a range of disea... |
PMC10044628 | core_pubmed_pmc | The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review | The Use of Antibiotics and Antimicrobial Resistance in Veterinary Medicine, a Complex Phenomenon: A Narrative Review Abstract Abstract As warned by Sir Alexander Fleming in his Nobel Prize address: “the use of antimicrobials can, and will, lead to resistance” . Antimicrobial resistance (AMR) has recently increased due ... |
PMC8187753 | core_pubmed_pmc | Advances in Therapeutic Drug Monitoring in Biologic Therapies for Pediatric Inflammatory Bowel Disease | Advances in Therapeutic Drug Monitoring in Biologic Therapies for Pediatric Inflammatory Bowel Disease Abstract Abstract In the current era of treat-to-target strategies, therapeutic drug monitoring (TDM) has emerged as a potential tool in optimizing the efficacy of biologics for children diagnosed with inflammatory bo... |
PMC8236893 | core_pubmed_pmc | Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies | Immune Response to Therapeutic Staphylococcal Bacteriophages in Mammals: Kinetics of Induction, Immunogenic Structural Proteins, Natural and Induced Antibodies Abstract Bacteriophages are able to affect the human immune system. Phage-specific antibodies are considered as major factors shaping phage pharmacokinetics and... |
PMC11840199 | core_pubmed_pmc | Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials | Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials Abstract Aim Obesity is a global epidemic. The FDA has approved glucagon-like peptide-1 (GLP-1) receptor agonists such as Liraglutide, Semaglutide, and the GLP-1/gastric inhibitory p... |
PMC6972670 | core_pubmed_pmc | A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti‐ CD 40 monoclonal antibody, in kidney transplantation | A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti‐ CD 40 monoclonal antibody, in kidney transplantation Abstract This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of various doses of the anti‐ CD 40 mon... |
PMC6153689 | core_pubmed_pmc | Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine | Exploration of serum biomarkers for predicting the response to Inchinkoto (ICKT), a Japanese traditional herbal medicine Abstract Introduction In patients with obstructive jaundice, biliary drainage sometimes fails to result in improvement. A pharmaceutical-grade choleretic herbal medicine, Inchinkoto (ICKT), has been ... |
PMC6349292 | core_pubmed_pmc | Successful Outcomes with Insulin Degludec in Pregnancy: A Case Series | Successful Outcomes with Insulin Degludec in Pregnancy: A Case Series Abstract Optimal glycaemic control pre-conception and throughout pregnancy is paramount to achieve the best outcomes and to minimise the risk of complications for the mother and baby. Current long-acting insulin analogues that have been approved by t... |
PMC7067192 | core_pubmed_pmc | Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy | Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy Abstract Abstract Co-delivery nanoparticles with characteristics of intracellular precision release drug have been generally accepted as an effective therapeutic strategy for eye diseases. In this study, we desig... |
PMC8748331 | core_pubmed_pmc | Population pharmacokinetics of cefotaxime in intensive care patients | Population pharmacokinetics of cefotaxime in intensive care patients Abstract Purpose To characterise the pharmacokinetics and associated variability of cefotaxime in adult intensive care unit (ICU) patients and to assess the impact of patient covariates. Methods This work was based on data from cefotaxime-treated pati... |
PMC9727382 | core_pubmed_pmc | Mathematical modeling in the health risk assessment of air pollution-related disease burden in China: A review | Mathematical modeling in the health risk assessment of air pollution-related disease burden in China: A review Abstract This review paper covers an overview of air pollution-related disease burden in China and a literature review on the previous studies which have recently adopted a mathematical modeling approach to de... |
PMC5099556 | core_pubmed_pmc | Comparative assessment of clinical response in patients with rheumatoid arthritis between PF‐05280586, a proposed rituximab biosimilar, and rituximab | Comparative assessment of clinical response in patients with rheumatoid arthritis between PF‐05280586, a proposed rituximab biosimilar, and rituximab Abstract Aims To evaluate potential differences between PF‐05280586 and rituximab sourced from the European Union (rituximab‐EU) and USA (rituximab‐US) in clinical respon... |
PMC10652811 | core_pubmed_pmc | Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor–positive Breast Cancer | Mathematical Modeling Identifies Optimum Palbociclib-fulvestrant Dose Administration Schedules for the Treatment of Patients with Estrogen Receptor–positive Breast Cancer Abstract Abstract Cyclin-dependent kinases 4/6 (CDK4/6) inhibitors such as palbociclib are approved for the treatment of metastatic estrogen receptor... |
PMC11779803 | core_pubmed_pmc | A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women | A high-fat meal significantly impacts the bioavailability and biphasic absorption of cannabidiol (CBD) from a CBD-rich extract in men and women Abstract Abstract Cannabidiol (CBD), a specialized metabolite (phytocannabinoid) abundant in Cannabis sativa , is attracting increasing attention for its alleged health-promoti... |
PMC6648052 | core_pubmed_pmc | Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors | Metabolites of Vinca Alkaloid Vinblastine: Tubulin Binding and Activation of Nausea-Associated Receptors Abstract Abstract Vinblastine (VLB) is an antimitotic drug that binds to the vinca site of tubulin. The molecule possesses a high molecular weight and a complex chemical structure with many possibilities of metaboli... |
PMC10377562 | core_pubmed_pmc | Comparison of the Pharmacokinetics, Safety, and Tolerability of Two Empagliflozin Formulations in Healthy Korean Subjects | Comparison of the Pharmacokinetics, Safety, and Tolerability of Two Empagliflozin Formulations in Healthy Korean Subjects Abstract Purpose Empagliflozin is a sodium-glucose cotransporter 2 inhibitor that is commonly used for the treatment of type 2 diabetes mellitus. As cocrystal formulation can improve the chemical pr... |
PMC7698654 | core_pubmed_pmc | Hydroxychloroquine lung pharmacokinetics in critically ill patients with COVID-19 | Hydroxychloroquine lung pharmacokinetics in critically ill patients with COVID-19 Abstract Highlights • HCQ pharmacokinetics in COVID-19 patients cannot be predicted using data from lupus or rheumatoid arthritis patients. • Bronchoalveolar lavage fluid may be a more instructive matrix than plasma on the degree of HCQ l... |
PMC5074546 | core_pubmed_pmc | Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study | Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study Abstract The complement 5a receptor has been an attractive therapeutic target for many autoimmune... |
PMC9146744 | core_pubmed_pmc | Cutaneous Ulcer Caused by Apixaban Treatment Is Resolved after Replacement with Dabigatran | Cutaneous Ulcer Caused by Apixaban Treatment Is Resolved after Replacement with Dabigatran Abstract Abstract Nowadays, novel oral anticoagulants (NOACs) have shown improved safety profile and efficacy compared to vitamin K antagonists in the prevention of thromboembolic events occurring during different pathological co... |
PMC8158435 | core_pubmed_pmc | Gender May Influence the Immunosuppressive Actions of Prednisone in Young Patients With Inflammatory Bowel Disease | Gender May Influence the Immunosuppressive Actions of Prednisone in Young Patients With Inflammatory Bowel Disease Abstract Although the use of glucocorticoids (GC) is well established, the therapeutic response to these agents often shows important interindividual differences, in particular among young patients with in... |
PMC4455846 | core_pubmed_pmc | Profile of guanfacine extended release and its potential in the treatment of attention-deficit hyperactivity disorder | Profile of guanfacine extended release and its potential in the treatment of attention-deficit hyperactivity disorder Abstract The α 2 -adrenergic receptor agonist guanfacine, in its extended-release formulation (GXR), is the most recent nonstimulant medication approved in several countries for the treatment of attenti... |
PMC9610912 | core_pubmed_pmc | Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review | Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review Abstract Abstract Ulcerative colitis (UC) is part of the inflammatory bowels diseases, and moderate to severe UC patients can be treated with anti-tumour ne... |
PMC4951586 | core_pubmed_pmc | Preparation and evaluation of a phospholipid-based injectable gel for the long term delivery of leuprolide acetaterrh | Preparation and evaluation of a phospholipid-based injectable gel for the long term delivery of leuprolide acetaterrh Abstract A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate (LA). The gel system was prepared using biocompatible materials (SPME), including soya phospha... |
PMC7851395 | core_pubmed_pmc | Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway | Acetyl-bufalin shows potent efficacy against non-small-cell lung cancer by targeting the CDK9/STAT3 signalling pathway Abstract Background Cyclin-dependent kinase 9 (CDK9) is a promising prognostic marker and therapeutic target in cancers. Bufalin is an effective anti-tumour agent; however, the clinical application of ... |
PMC12198611 | core_pubmed_pmc | Flavonoid-mediated biofilm inhibition and toxicological evaluation of Atriplex laciniata against multidrug-resistant MRSA | Flavonoid-mediated biofilm inhibition and toxicological evaluation of Atriplex laciniata against multidrug-resistant MRSA Abstract Abstract Multidrug-resistant (MDR) superbugs threaten the efficacy of antibiotics, so new drug formulations from synthetic or natural sources are needed to combat antimicrobial-resistant (A... |
PMC8643199 | core_pubmed_pmc | Assessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits | Assessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits Abstract Introduction Fungal keratitis (FK) remains a severe sight-threatening disease, and case management is difficult due to ocular intrinsic barriers and drug shortages. Econazole (ECZ), a broad-spec... |
PMC7072526 | core_pubmed_pmc | Pharmacokinetics of Sativex ® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders | Pharmacokinetics of Sativex ® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders Abstract Abstract The phytocannabinoid-based medicine Sativex ® is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients and is being investigated for other central and peripher... |
PMC12277872 | core_pubmed_pmc | Design, Synthesis, In Vitro, and In Silico Studies of 5‐(Diethylamino)‐2‐Formylphenyl Naphthalene‐2‐Sulfonate Based Thiosemicarbazones as Potent Anti‐Alzheimer Agents | Design, Synthesis, In Vitro, and In Silico Studies of 5‐(Diethylamino)‐2‐Formylphenyl Naphthalene‐2‐Sulfonate Based Thiosemicarbazones as Potent Anti‐Alzheimer Agents Abstract ABSTRACT Alzheimer's disease (AD) is known as one of the more devastating neurodegenerative diseases diagnosed in older people. Cholinesterase i... |
PMC6201115 | core_pubmed_pmc | Can We Improve Stavudine's Safety Profile in Children? Pharmacokinetics of Intracellular Stavudine Triphosphate with Reduced Dosing | Can We Improve Stavudine's Safety Profile in Children? Pharmacokinetics of Intracellular Stavudine Triphosphate with Reduced Dosing Abstract Stavudine remains a useful replacement option for treatment for HIV + children. WHO reduced the adult dose to 30 mg twice daily, which maintains efficacy and lowers mitochondrial ... |
PMC12597936 | core_pubmed_pmc | Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction | Strategy advancements in placental pharmacokinetics: from in vitro experiments to in silico prediction Abstract Abstract Background The placental barrier is a critical interface that regulates drug transport between maternal and fetal circulation and is an important component in assessing fetal drug-exposure risk. Sinc... |
PMC7543481 | core_pubmed_pmc | A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies | A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies Abstract Abstract There are many gaps in scientific knowledge about the clinical significance of pharmacokinetic natural product–drug interactions (NPDIs) in which the natural product (NP) is ... |
PMC5811788 | core_pubmed_pmc | Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects | Effects of Rifampin on the Pharmacokinetics of a Single Dose of Istradefylline in Healthy Subjects Abstract Abstract Istradefylline, a selective adenosine A 2A inhibitor, is under development for the treatment of Parkinson's disease. The effect of oral steady‐state rifampin 600 mg/day, a potent cytochrome P450 (CYP) 3A... |
PMC12856970 | core_pubmed_pmc | Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants | Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants Abstract Abstract Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two‐treatment‐period, drug‐drug interacti... |
PMC10514545 | core_pubmed_pmc | Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications | Pharmacokinetic Interactions Between Antiseizure and Psychiatric Medications Abstract Abstract Antiseizure medications and drugs for psychiatric diseases are frequently used in combination. In this context, pharmacokinetic interactions between these drugs may occur. The vast majority of these interactions are primarily... |
PMC10284934 | core_pubmed_pmc | Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors | Mechanisms of preferential bone formation in myeloma bone lesions by proteasome inhibitors Abstract Proteasome inhibitors (PIs) can preferentially restore bone in bone-defective lesions of patients with multiple myeloma (MM) who respond favorably to these drugs. Most prior in vitro studies on PIs used continuous exposu... |
PMC7508583 | core_pubmed_pmc | Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives | Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives Abstract Giardiasis, caused by the intestinal parasite Giardia lamblia , is a severe diarrheal disease, endemic in poverty-stricken regions of the world, and also a common infection in developed countries. The available therapeutic options a... |
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