id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC4846783 | core_pubmed_pmc | Edoxaban Exposure‐Response Analysis and Clinical Utility Index Assessment in Patients With Symptomatic Deep‐Vein Thrombosis or Pulmonary Embolism | Edoxaban Exposure‐Response Analysis and Clinical Utility Index Assessment in Patients With Symptomatic Deep‐Vein Thrombosis or Pulmonary Embolism Abstract Abstract Edoxaban exposure‐response relationships from the phase III study evaluating edoxaban for prevention and treatment of venous thromboembolism (VTE) in patien... |
PMC6538963 | core_pubmed_pmc | Effects of Tokishakuyakusan on Regeneration of Murine Olfactory Neurons In Vivo and In Vitro | Effects of Tokishakuyakusan on Regeneration of Murine Olfactory Neurons In Vivo and In Vitro Abstract Abstract Post-upper respiratory tract infection related olfactory dysfunction typically occurs due to neural damage after an upper respiratory tract infection associated with a common cold or influenza. At present, Tok... |
PMC8411703 | core_pubmed_pmc | Population Pharmacokinetics of Vancomycin and Meropenem in Pediatric Extracorporeal Membrane Oxygenation Support | Population Pharmacokinetics of Vancomycin and Meropenem in Pediatric Extracorporeal Membrane Oxygenation Support Abstract Objective: Describe primary pharmacokinetic/pharmacodynamic (PK/PD) parameters of vancomycin and meropenem in pediatric patients undergoing ECMO and analyze utilized dosing to reach PK/PD target. De... |
PMC7844923 | core_pubmed_pmc | Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist | Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist Abstract Abstract Background Interleukin-17A (IL17A) is a proinflammatory cytokine critically involved in autoimmune diseases, and monoclonal antibodies of IL17A have been approved for clinical treatment of psoriasis. Howev... |
PMC8563921 | core_pubmed_pmc | External qualification of the Web‐Accessible Population Pharmacokinetic Service–Hemophilia (WAPPS‐Hemo) models for octocog alfa using real patient data | External qualification of the Web‐Accessible Population Pharmacokinetic Service–Hemophilia (WAPPS‐Hemo) models for octocog alfa using real patient data Abstract Abstract Background Existing adult patient pharmacokinetic (PK) data from the published Advate vs Kovaltry PK crossover study were used for this validation stu... |
PMC12046389 | core_pubmed_pmc | Population pharmacokinetic model of oral minocycline in critically ill adult patients with ventilator-associated pneumonia | Population pharmacokinetic model of oral minocycline in critically ill adult patients with ventilator-associated pneumonia Abstract Abstract Objectives Multidrug-resistant Acinetobacter baumannii (MDR- A. baumannii ) has become an emerging pathogen, causing ventilator-associated pneumonia (VAP), with limited treatment ... |
PMC6751510 | core_pubmed_pmc | Generics in transplantation medicine: Randomized comparison of innovator and substitution products containing mycophenolate mofetil | Generics in transplantation medicine: Randomized comparison of innovator and substitution products containing mycophenolate mofetil Abstract Abstract Objective: Mycophenolate mofetil (MMF) is widely used as an immunosuppressant for the prophylaxis of acute organ rejection in recipients of solid organ transplants. Mater... |
PMC10275280 | core_pubmed_pmc | Systemic administration of the antisense oligonucleotide NS ‐089/ NCNP ‐02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/ II clinical trial | Systemic administration of the antisense oligonucleotide NS ‐089/ NCNP ‐02 for skipping of exon 44 in patients with Duchenne muscular dystrophy: Study protocol for a phase I/ II clinical trial Abstract Abstract Aim The purpose of this study is to evaluate the safety and pharmacokinetics of the novel morpholino oligomer... |
PMC7241499 | core_pubmed_pmc | Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism | Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism Abstract Abstract Sinomenine (SIN) is an anti-inflammatory alkaloid derived from Sinomenium acutum , and the products sinomenine hydrochloride (SH) tablets... |
PMC6084080 | core_pubmed_pmc | Praziquantel–lipid nanocapsules: an oral nanotherapeutic with potential Schistosoma mansoni tegumental targeting | Praziquantel–lipid nanocapsules: an oral nanotherapeutic with potential Schistosoma mansoni tegumental targeting Abstract Purpose Lipid nanocapsules (LNCs) have shown potential to increase the bioavailability and efficacy of orally administered drugs. However, their intestinal translocation to distal target sites and t... |
PMC12327012 | core_pubmed_pmc | Distribution of acyclovir in central nervous system compartments: a porcine pharmacokinetic model | Distribution of acyclovir in central nervous system compartments: a porcine pharmacokinetic model Abstract ABSTRACT Herpes simplex virus (HSV) encephalitis is a severe infection with high mortality and neurological sequelae if untreated. Intravenous acyclovir (ACV) is the standard treatment, but its central nervous sys... |
PMC12209695 | core_pubmed_pmc | Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses | Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses Abstract ABSTRACT Ethanol, a central nervous system depressant and banned substance in horseracing, has reportedly been administered to horses prior to competi... |
PMC11008023 | core_pubmed_pmc | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis | Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis Abstract Abstract Background Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, t... |
PMC10310785 | core_pubmed_pmc | Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics | Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics Abstract Abstract The addition of protonating acids to e-cigarette liquid formulations (e-liquids) enhances nicotine bioavailability in e-cigarette use. However, little is known about... |
PMC10336191 | core_pubmed_pmc | The right time to measure anti-Xa activity in critical illness: pharmacokinetics of therapeutic dose nadroparin | The right time to measure anti-Xa activity in critical illness: pharmacokinetics of therapeutic dose nadroparin Abstract Background Peak anti-Xa activity of low-molecular-weight heparin nadroparin is measured 3 to 5 hours after subcutaneous injection. In critically ill patients, physiological changes and medical therap... |
PMC4881294 | core_pubmed_pmc | Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson’s disease | Motor fluctuations due to interaction between dietary protein and levodopa in Parkinson’s disease Abstract Abstract Background The modulation of levodopa transport across the blood brain barrier by large neutral amino acids is well documented. Protein limitation and protein redistribution diets may improve motor fluctu... |
PMC7076450 | core_pubmed_pmc | Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging | Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging Abstract Many tools for studying the pharmacokinetics of biologics lack single-cell resolution to quantify the heterogeneous tissue distribution and subsequent therapeuti... |
PMC10945527 | core_pubmed_pmc | Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers | Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers Abstract Background: Primaquine is an 8-aminoquinoline antimalarial. It is the only widely available treatment to prevent relapses of Plasmodium vivax malaria. The 8-aminoqu... |
PMC6542380 | core_pubmed_pmc | A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation | A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation Abstract Abstract Objective Prescription opioid abuse continues to be a public health concern. Oxycodone ARIR is an immediate-release (IR) oxyco... |
PMC8854719 | core_pubmed_pmc | Phase 1A/1B dose-escalation and -expansion study to evaluate the safety, pharmacokinetics, food effects and antitumor activity of pamiparib in advanced solid tumours | Phase 1A/1B dose-escalation and -expansion study to evaluate the safety, pharmacokinetics, food effects and antitumor activity of pamiparib in advanced solid tumours Abstract Background Pamiparib, a PARP1/2 inhibitor, demonstrated antitumor activity in preclinical models. Methods This Phase 1A/1B dose-escalation/dose-e... |
PMC8148615 | core_pubmed_pmc | Accommodating receptor flexibility and free energy calculation to reduce false positive binders in the discovery of natural products blockers of SARS-COV-2 spike RBD-ACE2 interface | Accommodating receptor flexibility and free energy calculation to reduce false positive binders in the discovery of natural products blockers of SARS-COV-2 spike RBD-ACE2 interface Abstract Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which causes coronavirus disease-19 (COVID... |
PMC11109453 | core_pubmed_pmc | Current status, challenges and prospects of antifouling materials for oncology applications | Current status, challenges and prospects of antifouling materials for oncology applications Abstract Targeted therapy has become crucial to modern translational science, offering a remedy to conventional drug delivery challenges. Conventional drug delivery systems encountered challenges related to solubility, prolonged... |
PMC8802112 | core_pubmed_pmc | Secondhand Smoking and Sudden Infant Death Syndrome: How can in Silico Pharmacokinetics and Circulation Models Contribute? | Secondhand Smoking and Sudden Infant Death Syndrome: How can in Silico Pharmacokinetics and Circulation Models Contribute? Modeling Paediatric Pharmacokinetic Models The purpose of pharmacokinetic models is to quantify the absorption, distribution, metabolism, and excretion (ADME) of a drug/compound in the body. PBPK m... |
PMC11494824 | core_pubmed_pmc | Population pharmacokinetic modeling of sufentanil in adult Korean patients undergoing cardiopulmonary bypass surgery | Population pharmacokinetic modeling of sufentanil in adult Korean patients undergoing cardiopulmonary bypass surgery Abstract Abstract Sufentanil is frequently used as an anesthetic agent in cardiac surgery owing to its cardiovascular safety and favorable pharmacokinetics. However, the pharmacokinetics profiles of sufe... |
PMC12256671 | core_pubmed_pmc | Tutorial for Modeling Delays in Biological Systems in the NONMEM Software | Tutorial for Modeling Delays in Biological Systems in the NONMEM Software Abstract ABSTRACT Delays in biological systems are a common phenomenon. The models for delays require specialized mathematical and numerical techniques such as transit compartments, delay differential equations (DDEs), and distributed DDEs (DDDEs... |
PMC12427341 | core_pubmed_pmc | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination | Phytochemical-Mediated Modulation of Doramectin Pharmacology in Sheep: Exploring the Cinnamaldehyde–Pink Grapefruit Combination Abstract Simple Summary In the context of increasing anthelmintic resistance, the search for novel strategies to control gastrointestinal nematodes in ruminants is urgent. Various plant-derive... |
PMC12655601 | core_pubmed_pmc | The Association Between Genetic Polymorphisms of UGT1A1 , ABCG2 , and NR1I2 and Dolutegravir Pharmacokinetic Parameters in Thai People Living with HIV | The Association Between Genetic Polymorphisms of UGT1A1 , ABCG2 , and NR1I2 and Dolutegravir Pharmacokinetic Parameters in Thai People Living with HIV Abstract Abstract Background/Objectives : Dolutegravir (DTG) is recommended as first-line treatment for Thai people living with HIV (PLWH). Real-world studies show high ... |
PMC8864998 | core_pubmed_pmc | Flomoxef for neonates: extending options for treatment of neonatal sepsis caused by ESBL-producing Enterobacterales | Flomoxef for neonates: extending options for treatment of neonatal sepsis caused by ESBL-producing Enterobacterales Abstract Abstract Background Neonatal sepsis is a serious and frequently lethal infection, often complicated by antimicrobial resistance (including ESBLs) in low- and middle-income countries (LMICs). Flom... |
PMC10256639 | core_pubmed_pmc | Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children | Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug–Drug Interactions in Children Abstract Abstract Background and Objective Spinal muscular atrophy (SMA) is a progressive neuromuscular disease caused by insufficient levels of survival motor neuron (SMN) p... |
PMC11215403 | core_pubmed_pmc | Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors | Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity from a Phase I Study of Simlukafusp Alfa (FAP-IL2v) in Advanced/Metastatic Solid Tumors Abstract Purpose: Simlukafusp alfa [fibroblast activation protein α–targeted IL2 variant (FAP-IL2v)], a tumor-targeted immunocytokine, comprising an IL2 variant moie... |
PMC7711656 | core_pubmed_pmc | Rezafungin—Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins | Rezafungin—Mechanisms of Action, Susceptibility and Resistance: Similarities and Differences with the Other Echinocandins Abstract Abstract Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-ac... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.