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32,459,655
J Med Internet Res
Improvements in Patient Monitoring in the Intensive Care Unit: Survey Study.
BACKGROUND: Due to demographic change and, more recently, coronavirus disease (COVID-19), the importance of modern intensive care units (ICU) is becoming apparent. One of the key components of an ICU is the continuous monitoring of patients' vital parameters. However, existing advances in informatics, signal processing...
redcap;digital health;email;intensive care medicine;intensive care unit;monitoring;online survey;patient monitoring;technological innovation;transdisciplinary;usability;user-centered
Journal Article
Poncette, Akira-Sebastian;Mosch, Lina;Spies, Claudia;Schmieding, Malte;Schiefenhovel, Fridtjof;Krampe, Henning;Balzer, Felix
10.2196/19091
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Improvements in Patient Monitoring in the Intensive Care Unit: Survey Study. [Abstract]: BACKGROUND: Due to demographic change and, more recently, coronavirus disease (COVID-19), the importance of modern intensive care units (ICU) is becoming apparent. One of the key components of an ICU is the continuous moni...
32,600,099
Otolaryngol Head Neck Surg
Reverse-Surge Planning During the COVID-19 Pandemic: A Cautionary Ramp-up for the Otolaryngologist.
As the coronavirus disease 2019 (COVID-19) pandemic continues to evolve through the United States and other countries, differing rates of progression and decline are occurring based on varied population densities. While some health systems are reaching a steady state of new patient cases, others are seeing a leveling o...
covid-19;aerosol generating procedures;pandemic;personal protective equipment;reverse-surge;telehealth
Journal Article
Shipchandler, Taha Z;Nesemeier, B Ryan;Barnes, Kaitlyn J;Kelly, Leah R;Schmalbach, Cecelia E;Ting, Jonathan Y
10.1177/0194599820938045
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Reverse-Surge Planning During the COVID-19 Pandemic: A Cautionary Ramp-up for the Otolaryngologist. [Abstract]: As the coronavirus disease 2019 (COVID-19) pandemic continues to evolve through the United States and other countries, differing rates of progression and decline are occurring based on varied populat...
32,425,710
J Am Coll Radiol
Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Imaging Case Volumes.
OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has had significant economic impact on radiology with markedly decreased imaging case volumes. The purpose of this study was to quantify the imaging volumes during the COVID-19 pandemic across patient service locations and imaging modality types. METHODS: Imag...
covid-19;imaging volume;modality types;patient service locations
Journal Article
Naidich, Jason J;Boltyenkov, Artem;Wang, Jason J;Chusid, Jesse;Hughes, Danny;Sanelli, Pina C
10.1016/j.jacr.2020.05.004
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Imaging Case Volumes. [Abstract]: OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has had significant economic impact on radiology with markedly decreased imaging case volumes. The purpose of this study was to quantify the imaging volume...
32,651,894
J Endocrinol Invest
Pituitary surgery during Covid-19: a first hand experience and evaluation.
PURPOSE: During the Covid-19 pandemic every hospital has had to change its internal organization. Different institutions have highlighted the risks connected with endoscopic endonasal surgery. The goal of this paper is to illustrate the feasibility of pituitary region surgery during the SARS-CoV-2 pandemic. METHODS: Af...
covid-19 pandemic;endoscopic endonasal surgery;pituitary surgery
Journal Article
Penner, F;Grottoli, S;Lanotte, M M R;Garbossa, D;Zenga, F
10.1007/s40618-020-01354-x
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Pituitary surgery during Covid-19: a first hand experience and evaluation. [Abstract]: PURPOSE: During the Covid-19 pandemic every hospital has had to change its internal organization. Different institutions have highlighted the risks connected with endoscopic endonasal surgery. The goal of this paper is to il...
32,587,179
Indian J Ophthalmol
Glycerol-preserved corneal tissue in emergency corneal transplantation: An alternative for fresh corneal tissue in COVID-19 crisis.
Purpose: Due to the COVID-19 pandemic, most of the eye banks have limited/stopped corneal collection, as this is a highly contagious disease. This has led to shortage of donor corneas worldwide. Glycerol preservation of tissue remains a viable option in this scenario. The objective is to compare fresh corneal tissue (F...
corneal transplant;fresh corneal tissue;glycerol-preserved cornea;keratitis;therapeutic keratoplasty
Journal Article
Gupta, Neeti;Dhasmana, Renu;Maitreya, Amit;Badahur, Harsh
10.4103/ijo.IJO_1198_20
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Glycerol-preserved corneal tissue in emergency corneal transplantation: An alternative for fresh corneal tissue in COVID-19 crisis. [Abstract]: Purpose: Due to the COVID-19 pandemic, most of the eye banks have limited/stopped corneal collection, as this is a highly contagious disease. This has led to shortage ...
32,640,414
Diabetes Metab Syndr
Vitamin D deficiency in patients with diabetes and COVID- 19 infection.
BACKGROUND AND AIMS: Data show that vitamin D deficiency may play a role in patients with diabetes mellitus and COVID-19 infection. In this article, we review evidence of vitamin D deficiency and COVID-19 infection in context of diabetes mellitus. METHODS: A literature search was carried out by using the key term 'COVI...
covid-19;diabetes mellitus;vitamin d
Journal Article;Review
Singh, S K;Jain, Rujul;Singh, Shipra
10.1016/j.dsx.2020.06.071
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Vitamin D deficiency in patients with diabetes and COVID- 19 infection. [Abstract]: BACKGROUND AND AIMS: Data show that vitamin D deficiency may play a role in patients with diabetes mellitus and COVID-19 infection. In this article, we review evidence of vitamin D deficiency and COVID-19 infection in context o...
32,680,715
Rev Med Interne
[Nasopharyngeal carriage of SARS-CoV-2 among health personnel with symptoms suggestive of COVID-19 in a University Hospital in the Paris suburbs].
INTRODUCTION: A consultation dedicated to symptomatic health professionals was opened at the beginning of the COVID-19 epidemic in order to meet the specific needs of this population. The objective of this work was to estimate the frequency of SARS-Cov-2 nasopharyngeal carriage in symptomatic healthcare workers suspect...
covid-19;clinical symptoms;healthcare workers;personnels de sante;rt-pcr screening;sars-cov-2;symptomes cliniques;test rt-pcr
Journal Article
Greffe, S;Espinasse, F;Duran, C;Labrune, S;Sirol, M;Mantalvan, B;Gramer, M C;Babulle, C;Do Rosario, G;Vauvillier, Q;Huet, A;Van der Heidjen, A;Tysebaert, J;Kramarz, L F;Rabes, J-P;Pellissier, G;Chinet, T;Moreau, F;Rouveix, E
10.1016/j.revmed.2020.06.017
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: [Nasopharyngeal carriage of SARS-CoV-2 among health personnel with symptoms suggestive of COVID-19 in a University Hospital in the Paris suburbs]. [Abstract]: INTRODUCTION: A consultation dedicated to symptomatic health professionals was opened at the beginning of the COVID-19 epidemic in order to meet the spe...
32,436,355
Andrology
Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients.
BACKGROUND: The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. Epidemiological data showing a differential impact of SARS-CoV-2 infection on women and men ...
covid-19;inflammatory markers;mortality;prognosis;sex hormones
Journal Article
Rastrelli, Giulia;Di Stasi, Vincenza;Inglese, Francesco;Beccaria, Massimiliano;Garuti, Martina;Di Costanzo, Domenica;Spreafico, Fabio;Greco, Graziana Francesca;Cervi, Giulia;Pecoriello, Antonietta;Magini, Angela;Todisco, Tommaso;Cipriani, Sarah;Maseroli, Elisa;Corona, Giovanni;Salonia, Andrea;Lenzi, Andrea;Maggi, Mario...
10.1111/andr.12821
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. [Abstract]: BACKGROUND: The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical wors...
32,894,772
J Am Med Inform Assoc
Racial and Ethnic Differences in Self-Reported Telehealth Use during the COVID-19 Pandemic: A Secondary Analysis of a U.S. Survey of Internet Users from Late March.
OBJECTIVE: Widespread technological changes, like the rapid uptake of telehealth in the U.S. during the COVID-19 pandemic, risk creating or widening racial/ethnic disparities. We conducted a secondary analysis of a cross-sectional, nationally representative survey of Internet users to evaluate whether there were racial...
Journal Article
Campos-Castillo, Celeste;Anthony, Denise
10.1093/jamia/ocaa221
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Racial and Ethnic Differences in Self-Reported Telehealth Use during the COVID-19 Pandemic: A Secondary Analysis of a U.S. Survey of Internet Users from Late March. [Abstract]: OBJECTIVE: Widespread technological changes, like the rapid uptake of telehealth in the U.S. during the COVID-19 pandemic, risk creati...
32,880,262
S Afr Med J
Preparing healthcare facilities to operate safely and effectively during the COVID-19 pandemic: The missing piece in the puzzle.
The stated objective of the COVID-19 lockdown was to allow time to prepare healthcare facilities. Preparation must include administrative and environmental measures, which when combined with personal protective equipment, minimise the risk of the spread of infection to patients and healthcare workers (HCWs) in faciliti...
Journal Article
Wilkinson, L S;Moosa, S;Cooke, R;Muller, A M;Boyles, T H
10.7196/SAMJ.2020.v110i9.150
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Preparing healthcare facilities to operate safely and effectively during the COVID-19 pandemic: The missing piece in the puzzle. [Abstract]: The stated objective of the COVID-19 lockdown was to allow time to prepare healthcare facilities. Preparation must include administrative and environmental measures, whic...
32,265,365
Anesth Analg
Obstetric Anesthesia During the COVID-19 Pandemic.
With increasing numbers of coronavirus disease 2019 (COVID-19) cases due to efficient human-to-human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States, preparation for the unpredictable setting of labor and delivery is paramount. The priorities are 2-fold in the managemen...
Journal Article;Review
Bauer, Melissa E;Bernstein, Kyra;Dinges, Emily;Delgado, Carlos;El-Sharawi, Nadir;Sultan, Pervez;Mhyre, Jill M;Landau, Ruth
10.1213/ANE.0000000000004856
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: Obstetric Anesthesia During the COVID-19 Pandemic. [Abstract]: With increasing numbers of coronavirus disease 2019 (COVID-19) cases due to efficient human-to-human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States, preparation for the unpredictable setting of lab...
33,066,917
J Stroke Cerebrovasc Dis
COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center.
BACKGROUND: An increased rate of thrombotic events has been associated to Coronavirus Disease 19 (COVID-19) with a variable rate of acute stroke. Our aim is to uncover the rate of acute stroke in COVID-19 patients and identify those cases in which a possible causative relationship could exist. METHODS: We performed a s...
acute stroke;covid-19;critical care;pandemic
Journal Article
Requena, Manuel;Olive-Gadea, Marta;Muchada, Marian;Garcia-Tornel, Alvaro;Deck, Matias;Juega, Jesus;Boned, Sandra;Rodriguez-Villatoro, Noelia;Pinana, Carlos;Pagola, Jorge;Rodriguez-Luna, David;Hernandez, David;Rubiera, Marta;Tomasello, Alejandro;Molina, Carlos A;Ribo, Marc
10.1016/j.jstrokecerebrovasdis.2020.105225
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: COVID-19 and Stroke: Incidence and Etiological Description in a High-Volume Center. [Abstract]: BACKGROUND: An increased rate of thrombotic events has been associated to Coronavirus Disease 19 (COVID-19) with a variable rate of acute stroke. Our aim is to uncover the rate of acute stroke in COVID-19 patients a...
32,705,079
Forensic Sci Int
Collection and disinfection of forensic biological specimens in five cases concerning COVID-19 in Guangzhou, China.
There have been many cases of pneumonia caused by novel coronavirus infections in China and around the world. This will inevitably lead to a rise in the number of patients. At the present time, clinical and forensic autopsies have given guidance and explanations in relation to the problem of COVID-19 transmission and d...
biological specimens;biosecurity;covid-19;forensic biology
Journal Article
Yang, Xingyi;Xu, Quyi;Liu, Hong;Xu, Jichao;Yang, Dian;Xiao, Cheng;Hu, Huiying;Liu, Yunyun;Liu, Chao
10.1016/j.fsisyn.2020.06.002
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Collection and disinfection of forensic biological specimens in five cases concerning COVID-19 in Guangzhou, China. [Abstract]: There have been many cases of pneumonia caused by novel coronavirus infections in China and around the world. This will inevitably lead to a rise in the number of patients. At the pre...
32,233,642
Ann Palliat Med
Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus.
BACKGROUND: The emerging infection of the 2019 novel coronavirus (2019-nCoV) in late December, 2019 in Wuhan, China, has caused an extreme health concern, with many patients having progressed to acute respiratory disease or other complications in a short period. Meanwhile, the risk factors associated with the disease p...
2019 novel coronavirus (2019-ncov);aggravation;disease progression;immune response;risk factors
Journal Article
Zhou, Yulong;Zhang, Zhicheng;Tian, Jie;Xiong, Shaoyun
10.21037/apm.2020.03.26
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus. [Abstract]: BACKGROUND: The emerging infection of the 2019 novel coronavirus (2019-nCoV) in late December, 2019 in Wuhan, China, has caused an extreme health concern, with many patients having pro...
32,864,545
J Endocr Soc
The Resilient Child: Sex-Steroid Hormones and COVID-19 Incidence in Pediatric Patients.
Coronavirus disease-2019 (COVID-19), a disease caused by Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has become an unprecedented global health emergency, with fatal outcomes among adults of all ages in the United States, and the highest incidence and mortality in adult men. As the pandemic evolves...
androgens;children;estrogens;immune system;puberty
Journal Article;Review
Mihalopoulos, Meredith;Levine, Alice C;Marayati, Naoum Fares;Chubak, Barbara M;Archer, Maddison;Badani, Ketan K;Tewari, Ashutosh K;Mohamed, Nihal;Ferrer, Fernando;Kyprianou, Natasha
10.1210/jendso/bvaa106
[ 1, 0, 1, 1, 0, 0, 0 ]
[Title]: The Resilient Child: Sex-Steroid Hormones and COVID-19 Incidence in Pediatric Patients. [Abstract]: Coronavirus disease-2019 (COVID-19), a disease caused by Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has become an unprecedented global health emergency, with fatal outcomes among adults of...
33,046,113
Crit Care
Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study.
BACKGROUND: Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification therapies (EBP) might support renal function, attenuate systemic inflammation, and prevent or mitigat...
acute renal injury;il-6;multiorgan dysfunction;sofa score
Journal Article;Observational Study;Research Support, Non-U.S. Gov't
Villa, Gianluca;Romagnoli, Stefano;De Rosa, Silvia;Greco, Massimiliano;Resta, Marco;Pomare Montin, Diego;Prato, Federico;Patera, Francesco;Ferrari, Fiorenza;Rotondo, Giuseppe;Ronco, Claudio
10.1186/s13054-020-03322-6
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study. [Abstract]: BACKGROUND: Systemic inflammation in COVID-19 often leads to multiple organ failure, including acute kidney injury (AKI). Renal replacement t...
32,388,129
Sci Total Environ
The nexus between COVID-19, temperature and exchange rate in Wuhan city: New findings from partial and multiple wavelet coherence.
This study attempts to document the nexus between weather, COVID-19 outbreak in Wuhan and the Chinese economy. We used daily average temperature (hourly data), daily new confirmed cases of COVID-19 in Wuhan, and RMB (Chinese currency) exchange rate to represent the weather, COVID-19 outbreak and the Chinese economy, re...
covid-19;partial and multiple wavelet coherence;rmb exchange rate;temperature;wuhan
Journal Article
Iqbal, Najaf;Fareed, Zeeshan;Shahzad, Farrukh;He, Xin;Shahzad, Umer;Lina, Ma
10.1016/j.scitotenv.2020.138916
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: The nexus between COVID-19, temperature and exchange rate in Wuhan city: New findings from partial and multiple wavelet coherence. [Abstract]: This study attempts to document the nexus between weather, COVID-19 outbreak in Wuhan and the Chinese economy. We used daily average temperature (hourly data), daily ne...
33,039,922
Int J Hyg Environ Health
SARS-CoV-2 in wastewater: Challenges for developing countries.
The COVID-19 pandemic that has engulfed the world, has affected the human lives in several aspects. The detection of SARS-CoV-2 in faeces and urine of the infected person, even after viral clearance in the respiratory tract, and its presence in untreated wastewater raises the possibility of fecal-oral transmission in f...
covid-19;developing nations;fecal-oral transmission;sars-cov-2;sanitation;wastewater
Journal Article;Review
Pandey, Deepshikha;Verma, Shelly;Verma, Priyanka;Mahanty, Biswanath;Dutta, Kasturi;Daverey, Achlesh;Arunachalam, Kusum
10.1016/j.ijheh.2020.113634
[ 0, 0, 1, 0, 1, 0, 0 ]
[Title]: SARS-CoV-2 in wastewater: Challenges for developing countries. [Abstract]: The COVID-19 pandemic that has engulfed the world, has affected the human lives in several aspects. The detection of SARS-CoV-2 in faeces and urine of the infected person, even after viral clearance in the respiratory tract, and its pre...
32,761,270
Arch Virol
Detection of SARS-CoV-2 by RNAscope((R)) in situ hybridization and immunohistochemistry techniques.
In situ hybridization (ISH) and immunohistochemistry (IHC) are essential tools to characterize SARS-CoV-2 infection and tropism in naturally and experimentally infected animals and also for diagnostic purposes. Here, we describe three RNAscope((R))-based ISH assays targeting the ORF1ab, spike, and nucleocapsid genes an...
Journal Article
Carossino, Mariano;Ip, Hon S;Richt, Juergen A;Shultz, Kendra;Harper, Kimberly;Loynachan, Alan T;Del Piero, Fabio;Balasuriya, Udeni B R
10.1007/s00705-020-04737-w
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Detection of SARS-CoV-2 by RNAscope((R)) in situ hybridization and immunohistochemistry techniques. [Abstract]: In situ hybridization (ISH) and immunohistochemistry (IHC) are essential tools to characterize SARS-CoV-2 infection and tropism in naturally and experimentally infected animals and also for diagnosti...
32,926,211
Abdom Radiol (NY)
Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review.
PURPOSE: This scoping review evaluated the currently available data related to abdominal imaging in the SARS-CoV-2 infection. METHOD: A systematic review of MEDLINE, EMBASE, SCOPUS, and Web of Science was performed from inception to July 15, 2020 using PRISMA-ScR guidelines. The review included case reports and series ...
2019-ncov;abdomen;covid-19;gastrointestinal;imaging;sars-cov-2
Journal Article;Research Support, Non-U.S. Gov't;Systematic Review
Lui, Kevin;Wilson, Mitchell P;Low, Gavin
10.1007/s00261-020-02739-5
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review. [Abstract]: PURPOSE: This scoping review evaluated the currently available data related to abdominal imaging in the SARS-CoV-2 infection. METHOD: A systematic review of MEDLINE, EMBASE, SCOPUS, and Web of Science was performed ...
32,674,650
J Int Med Res
How to prevent in-hospital COVID-19 infection and reassure women about the safety of pregnancy: Experience from an obstetric center in China.
OBJECTIVE: This study aimed to describe the emergency responses to coronavirus disease 2019 (COVID-19) for pregnant patients at our hospital and their effect on hospital operations and patients' outcomes. METHODS: We developed strategies to prevent hospital-associated transmission of COVID-19 in obstetric care. Infrast...
coronavirus disease 2019;depression;hospital-acquired infection;pregnancy outcome;psychological stability;telemedicine
Journal Article
Gu, Xiao-Xia;Chen, Kai;Yu, Hong;Liang, Ge-Yu;Chen, Hui;Shen, Yang
10.1177/0300060520939337
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: How to prevent in-hospital COVID-19 infection and reassure women about the safety of pregnancy: Experience from an obstetric center in China. [Abstract]: OBJECTIVE: This study aimed to describe the emergency responses to coronavirus disease 2019 (COVID-19) for pregnant patients at our hospital and their effect...
32,274,773
Anasthesiol Intensivmed Notfallmed Schmerzther
[SARS CoV-2/COVID-19: Evidence-Based Recommendation on Diagnosis and Therapy].
COVID-19, a new viral disease affecting primarily the respiratory system and the lung, has caused a pandemic with serious challenges to health systems around the world. In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. Morbidity is ...
Journal Article;Review
Bein, Berthold;Bachmann, Martin;Huggett, Susanne;Wegermann, Petra
10.1055/a-1146-8674
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: [SARS CoV-2/COVID-19: Evidence-Based Recommendation on Diagnosis and Therapy]. [Abstract]: COVID-19, a new viral disease affecting primarily the respiratory system and the lung, has caused a pandemic with serious challenges to health systems around the world. In about 20% of patients, severe symptoms occur aft...
32,737,472
Nat Hum Behav
Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil.
The first case of COVID-19 was detected in Brazil on 25 February 2020. We report and contextualize epidemiological, demographic and clinical findings for COVID-19 cases during the first 3 months of the epidemic. By 31 May 2020, 514,200 COVID-19 cases, including 29,314 deaths, had been reported in 75.3% (4,196 of 5,570)...
Journal Article;Research Support, Non-U.S. Gov't
de Souza, William Marciel;Buss, Lewis Fletcher;Candido, Darlan da Silva;Carrera, Jean-Paul;Li, Sabrina;Zarebski, Alexander E;Pereira, Rafael Henrique Moraes;Prete, Carlos A Jr;de Souza-Santos, Andreza Aruska;Parag, Kris V;Belotti, Maria Carolina T D;Vincenti-Gonzalez, Maria F;Messina, Janey;da Silva Sales, Flavia Crist...
10.1038/s41562-020-0928-4
[ 0, 1, 1, 0, 0, 1, 0 ]
[Title]: Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. [Abstract]: The first case of COVID-19 was detected in Brazil on 25 February 2020. We report and contextualize epidemiological, demographic and clinical findings for COVID-19 cases during the first 3 months of the epidemic. By 31 ...
32,846,157
Cell
Emerging Pandemic Diseases: How We Got to COVID-19.
Infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established infections, new infectious diseases periodically emerge. In extreme cases they may cause pandemics such as COVID-19; in other cases, dead-end infections or smaller epid...
covid-19;one health;disease ecology;epidemic;epizootic;infection;medical history;pandemic;virology;zoonosis
Journal Article;Review
Morens, David M;Fauci, Anthony S
10.1016/j.cell.2020.08.021
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Emerging Pandemic Diseases: How We Got to COVID-19. [Abstract]: Infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established infections, new infectious diseases periodically emerge. In extreme cases they may cause pandem...
32,604,825
Biology (Basel)
Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future.
The COVID-19 pandemic is rising at an unprecedented rate. The surging number of deaths every day, global lockdown and travel restrictions have resulted in huge losses to society. The impact is massive and will leave a historical footprint. The Spanish Flu of 1918, which was the last pandemic that had a similar impact, ...
covid-19;sars-cov-2;pandemic
Journal Article;Review
Pandey, Saurabh;Yadav, Bharat;Pandey, Arvind;Tripathi, Takshashila;Khawary, Masuma;Kant, Sashi;Tripathi, Deeksha
10.3390/biology9060141
[ 1, 1, 0, 1, 1, 0, 0 ]
[Title]: Lessons from SARS-CoV-2 Pandemic: Evolution, Disease Dynamics and Future. [Abstract]: The COVID-19 pandemic is rising at an unprecedented rate. The surging number of deaths every day, global lockdown and travel restrictions have resulted in huge losses to society. The impact is massive and will leave a histori...
32,835,245
Lancet Rheumatol
Anakinra for severe forms of COVID-19: a cohort study.
Background: Coronaviruses can induce the production of interleukin (IL)-1beta, IL-6, tumour necrosis factor, and other cytokines implicated in autoinflammatory disorders. It has been postulated that anakinra, a recombinant IL-1 receptor antagonist, might help to neutralise the severe acute respiratory syndrome coronavi...
Journal Article
Huet, Thomas;Beaussier, Helene;Voisin, Olivier;Jouveshomme, Stephane;Dauriat, Gaelle;Lazareth, Isabelle;Sacco, Emmanuelle;Naccache, Jean-Marc;Bezie, Yvonnick;Laplanche, Sophie;Le Berre, Alice;Le Pavec, Jerome;Salmeron, Sergio;Emmerich, Joseph;Mourad, Jean-Jacques;Chatellier, Gilles;Hayem, Gilles
10.1016/S2665-9913(20)30164-8
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Anakinra for severe forms of COVID-19: a cohort study. [Abstract]: Background: Coronaviruses can induce the production of interleukin (IL)-1beta, IL-6, tumour necrosis factor, and other cytokines implicated in autoinflammatory disorders. It has been postulated that anakinra, a recombinant IL-1 receptor antagon...
32,916,218
Food Chem Toxicol
Cardiac arrest and drug-related cardiac toxicity in the Covid-19 era. Epidemiology, pathophysiology and management.
SARS-CoV-2 (Covid-19) infection has recently become a worldwide challenge with dramatic global economic and health consequences. As the pandemic is still spreading, new data concerning Covid-19 complications and related mechanisms become increasingly available. Accumulating data suggest that the incidence of cardiac ar...
cardiac arrest;cardiopulmonary resuscitation;covid-19;covid-19 transmission;drug toxicity;heart complications
Journal Article;Review
Mavraganis, Georgios;Aivalioti, Evmorfia;Chatzidou, Sofia;Patras, Raphael;Paraskevaidis, Ioannis;Kanakakis, Ioannis;Stamatelopoulos, Kimon;Dimopoulos, Meletios-Athanasios
10.1016/j.fct.2020.111742
[ 1, 0, 1, 1, 0, 0, 0 ]
[Title]: Cardiac arrest and drug-related cardiac toxicity in the Covid-19 era. Epidemiology, pathophysiology and management. [Abstract]: SARS-CoV-2 (Covid-19) infection has recently become a worldwide challenge with dramatic global economic and health consequences. As the pandemic is still spreading, new data concernin...
32,636,075
J Infect Public Health
An unusual case of coronavirus disease 2019: Delayed chest CT evidence.
Asymptomatic patients and infected patients with normal chest CT imaging are considered carriers of SARS-CoV-2. Before a diagnosis of coronavirus disease 2019 (COVID-19) is made, these patients with negative chest CT findings may be ignored, causing the possibility of virus transmission. For patients with suspected inf...
covid-19;chest ct
Case Reports;Journal Article
Shi, Xiudong;Ma, Qiong;Lu, Yang;Shi, Yuxin
10.1016/j.jiph.2020.06.022
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: An unusual case of coronavirus disease 2019: Delayed chest CT evidence. [Abstract]: Asymptomatic patients and infected patients with normal chest CT imaging are considered carriers of SARS-CoV-2. Before a diagnosis of coronavirus disease 2019 (COVID-19) is made, these patients with negative chest CT findings m...
32,205,138
J Infect
The index case of SARS-CoV-2 in Scotland.
Since its identification in December 2019, SARS-CoV-2 has infected 125,048 persons globally with cases identified in 118 countries across all continents. We report on the Scottish index case of SARS-CoV-2 infection, the virus causing COVID-19.
communicable diseases, emerging;coronavirus;respiratory tract infections
Letter;Comment
Hill, Katherine J;Russell, Clark D;Clifford, Sarah;Templeton, Kate;Mackintosh, Claire L;Koch, Oliver;Sutherland, Rebecca K
10.1016/j.jinf.2020.03.022
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: The index case of SARS-CoV-2 in Scotland. [Abstract]: Since its identification in December 2019, SARS-CoV-2 has infected 125,048 persons globally with cases identified in 118 countries across all continents. We report on the Scottish index case of SARS-CoV-2 infection, the virus causing COVID-19. [Keywords]: c...
32,415,893
Head Neck
Coronavirus (COVID-19): Patient experience-Administrative services on the frontline during crisis.
The COVID-19 pandemic has had a dramatic impact on care delivery among health care institutions and providers in the United States. As a categorical cancer center, MD Anderson has prioritized care for our patients based on acuity of their disease. We continue to implement measures to protect patients and employees from...
cancer patients;coronavirus;exemptions;no visitor policy;patient experience
Journal Article
Overton, Judy;Denton, Kathy;Frumovitz, Michael;Lewis, Carol;Christensen, Sarah;Bezerra, Jaymesson;Hernandez, Chris;Walker, Michele S;Finder, Janice P;Proske, Ashlyn A;Jain, Sanchita;Whipple, Julai;Martinez, Wendi L;Eska, Jarrod S;Sutherland, Elizabeth W;Triche, Lisa L;Garcia, Elizabeth A;Weber, Randal S
10.1002/hed.26259
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Coronavirus (COVID-19): Patient experience-Administrative services on the frontline during crisis. [Abstract]: The COVID-19 pandemic has had a dramatic impact on care delivery among health care institutions and providers in the United States. As a categorical cancer center, MD Anderson has prioritized care for...
32,706,411
J Med Virol
Coinfection of other respiratory pathogens and HIV in COVID-19 patients: Is there a pattern?
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has led to the elaboration of multiple studies to increase knowledge and understanding, hence, having the ability to accomplish an adequate and timely diagnosis and give an optimal treatment according to the patient's condition. The cli...
sars coronavirus;coronavirus;human immunodeficiency virus;influenza virus;virus classification
Journal Article
Barrera-Lopez, Pedro;Perez-Riveros, Erika D;Moreno-Montoya, Jose;Ballesteros, Silvia Marcela;Valencia, Sergio A;De la Hoz-Valle, Jose A
10.1002/jmv.26331
[ 1, 1, 0, 1, 0, 0, 0 ]
[Title]: Coinfection of other respiratory pathogens and HIV in COVID-19 patients: Is there a pattern? [Abstract]: The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has led to the elaboration of multiple studies to increase knowledge and understanding, hence, having the ability to accom...
32,868,960
GeoJournal
The urban penalty of COVID-19 lockdowns across the globe: manifestations and lessons for Anglophone sub-Saharan Africa.
The paper contributes towards deciphering and decoding the misery of the urban poor in light of the COVID-19 scourge. The paper unpacks urban poverty in light of the corona virus. The emergence of the COVID-19 and the lack of any vaccines requires physical distancing as preventative measures to contain and reduce the s...
covid-19;informality;lockdown;management;pandemic;poverty;urban policy;urbanity
Journal Article
Chirisa, Innocent;Mutambisi, Tafadzwa;Chivenge, Marcyline;Mabaso, Elias;Matamanda, Abraham R;Ncube, Roselin
10.1007/s10708-020-10281-6
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: The urban penalty of COVID-19 lockdowns across the globe: manifestations and lessons for Anglophone sub-Saharan Africa. [Abstract]: The paper contributes towards deciphering and decoding the misery of the urban poor in light of the COVID-19 scourge. The paper unpacks urban poverty in light of the corona virus....
32,319,218
Am J Transplant
A case of SARS-CoV-2 pneumonia with successful antiviral therapy in a 77-year-old man with a heart transplant.
The SARS-CoV-2 infection can be seen as a single disease, but it also affects patients with relevant comorbidities who may have an increased risk of a severe course of infection. In this report, we present a 77-year-old patient with a heart transplant receiving relevant immunosuppressive therapy who tested positive for...
antibiotic: antiviral;clinical research/practice;heart transplantation/cardiology;immunosuppressant - calcineurin inhibitor: tacrolimus;immunosuppression/immune modulation;infection and infectious agents - viral;infectious disease;lung disease: infectious;off-label drug use
Case Reports;Journal Article
Mathies, Daniel;Rauschning, Dominic;Wagner, Ulrike;Mueller, Frank;Maibaum, Maja;Binnemann, Christin;Waldeck, Stephan;Thinnes, Katrin;Braun, Michael;Schmidbauer, Willi;Hagen, Ralf M;Bickel, Christoph
10.1111/ajt.15932
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: A case of SARS-CoV-2 pneumonia with successful antiviral therapy in a 77-year-old man with a heart transplant. [Abstract]: The SARS-CoV-2 infection can be seen as a single disease, but it also affects patients with relevant comorbidities who may have an increased risk of a severe course of infection. In this r...
32,894,811
Int J Clin Pract
Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients.
BACKGROUND: The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease. OBJECTIVE: In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigat...
Journal Article
Kutluhan, Musab Ali;Tas, Ahmet;Sahin, Aytac;Urkmez, Ahmet;Topaktas, Ramazan;Atac, Omer;Verit, Ayhan
10.1111/ijcp.13636
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients. [Abstract]: BACKGROUND: The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in C...
32,617,989
J Med Virol
Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
We conducted this systemic review and meta-analysis in an attempt to evaluate the efficacy and safety of umifenovir in coronavirus disease 2019 (COVID-19). We searched PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and medRxiv database. We included both retrospective and pros...
covid-19;efficacy;meta-analysis;safety;umifenovir
Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Systematic Review
Huang, Dong;Yu, He;Wang, Ting;Yang, Huan;Yao, Rong;Liang, Zongan
10.1002/jmv.26256
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. [Abstract]: We conducted this systemic review and meta-analysis in an attempt to evaluate the efficacy and safety of umifenovir in coronavirus disease 2019 (COVID-19). We searched PubMed, Web of Sc...
32,834,715
Curr Treat Options Neurol
Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic.
Background: The COVID-19 pandemic has affected healthcare systems, professionals and patients around the world. At the same time, the burden of cerebrovascular events is considerable. Worldwide, more than one million deaths per year are due to cerebrovascular events, which are the second most frequent cause of death an...
secondary cerebrovascular prevention - covid-19
Journal Article;Review
Padlina, G;Bellwald, S;Maurer, A;Heldner, M R
10.1007/s11940-020-00634-4
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic. [Abstract]: Background: The COVID-19 pandemic has affected healthcare systems, professionals and patients around the world. At the same time, the burden of cerebrovascular events is considerable. Worldwide, more than one million deaths per...
32,327,229
Clin Radiol
CT characteristics of patients infected with 2019 novel coronavirus: association with clinical type.
AIM: To summarise the features of chest computed tomography (CT) of a series of patients infected with 2019 novel coronavirus (2019-nCov) to speed up recognition and have a better understanding of COVID-19 disease. MATERIALS AND METHODS: The clinical information and chest CT images of 93 patients infected with 2019-nCo...
Journal Article
Wang, J;Xu, Z;Wang, J;Feng, R;An, Y;Ao, W;Gao, Y;Wang, X;Xie, Z
10.1016/j.crad.2020.04.001
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: CT characteristics of patients infected with 2019 novel coronavirus: association with clinical type. [Abstract]: AIM: To summarise the features of chest computed tomography (CT) of a series of patients infected with 2019 novel coronavirus (2019-nCov) to speed up recognition and have a better understanding of C...
32,602,404
Prog Transplant
New York Transplant Teams Versus COVID-19.
New York State, and especially New York City, were hit hard by the coronavirus disease 2019 (COVID-19) virus. While we followed its course in other parts of the world, and began preparations, there was no way we could have been prepared for the volume and severity of illness that began to overflow in our emergency depa...
covid-19;new york state;collaboration;communication;organ donation;transplantation;virus
Letter
Blackstock, Daryle;Butler, Laura;Delair, Samantha;Dokus, Katherine;Eileen, Farrington;Carolyn, Forman;Helen, Irving;Carrie, Lindower;Tania, Lyons;Nancy, Metzler;Janine, Morris;Brigitte, Sullivan;Demetra, Tsapepas;Ohler, Linda
10.1177/1526924820938346
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: New York Transplant Teams Versus COVID-19. [Abstract]: New York State, and especially New York City, were hit hard by the coronavirus disease 2019 (COVID-19) virus. While we followed its course in other parts of the world, and began preparations, there was no way we could have been prepared for the volume and ...
32,380,337
World Neurosurg
Neurosurgical Practice During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic: A Worldwide Survey.
BACKGROUND AND OBJECTIVE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has consistently changed medical practice throughout specialties, regardless of their contribution in facing the disease itself. We surveyed neurosurgeons worldwide to investigate the situation they are experiencing. MET...
covid-19;neurosurgery;survey
Journal Article
Fontanella, Marco M;De Maria, Lucio;Zanin, Luca;Saraceno, Giorgio;Terzi di Bergamo, Lodovico;Servadei, Franco;Chaurasia, Bipin;Olivi, Alessandro;Vajkoczy, Peter;Schaller, Karl;Cappabianca, Paolo;Doglietto, Francesco
10.1016/j.wneu.2020.04.204
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Neurosurgical Practice During the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic: A Worldwide Survey. [Abstract]: BACKGROUND AND OBJECTIVE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has consistently changed medical practice throughout specialties, regardle...
32,267,081
ACR Open Rheumatol
Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome.
OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin-1 receptor antagonist) infusions in treating severely ill adult patients with secondary hemophagocytic lymphohistiocytosis or macrophage activation...
Journal Article
Monteagudo, Luke Adam;Boothby, Aaron;Gertner, Elie
10.1002/acr2.11135
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome. [Abstract]: OBJECTIVE: The objective of this study was to report the benefit of a therapeutic approach consisting of intravenous (IV) continuous anakinra (recombinant human interleukin-1 receptor antagonist) ...
32,843,849
Process Biochem
A systematic review on recent trends in transmission, diagnosis, prevention and imaging features of COVID-19.
As the new cases of COVID-19 are growing every daysince January 2020, the major way to control the spread wasthrough early diagnosis. Prevention and early diagnosis are the key strategies followed by most countries. This study presents the perspective of different modes of transmission of coronavirus,especially during ...
covid-19;coronaviruses;pathogenesis;reproduction number;sars-cov-2;transmission
Journal Article;Review
Manigandan, S;Wu, Ming-Tsang;Ponnusamy, Vinoth Kumar;Raghavendra, Vinay B;Pugazhendhi, Arivalagan;Brindhadevi, Kathirvel
10.1016/j.procbio.2020.08.016
[ 0, 1, 1, 0, 1, 0, 0 ]
[Title]: A systematic review on recent trends in transmission, diagnosis, prevention and imaging features of COVID-19. [Abstract]: As the new cases of COVID-19 are growing every daysince January 2020, the major way to control the spread wasthrough early diagnosis. Prevention and early diagnosis are the key strategies f...
32,428,085
Braz Oral Res
Immunocompromised patients and coronavirus disease 2019: a review and recommendations for dental health care.
In less than four months, an unprecedented pandemic changed the world scenario, closing institutions and commerce, paralyzing sports championships, blocking frontiers, and putting almost all populations in a house quarantine regimen. Immunocompromised patients are within the high-risk group to severe outcomes from COVI...
Journal Article;Review
Martins-Chaves, Roberta Rayra;Gomes, Carolina Cavalieri;Gomez, Ricardo Santiago
10.1590/1807-3107bor-2020.vol34.0048
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Immunocompromised patients and coronavirus disease 2019: a review and recommendations for dental health care. [Abstract]: In less than four months, an unprecedented pandemic changed the world scenario, closing institutions and commerce, paralyzing sports championships, blocking frontiers, and putting almost al...
32,354,030
Int J Mol Sci
Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work.
BACKGROUND: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a ...
covid-19;il-6;adiponectin;diet therapies;lung infections;omega-3 pufas
Journal Article;Review
Messina, Giovanni;Polito, Rita;Monda, Vincenzo;Cipolloni, Luigi;Di Nunno, Nunzio;Di Mizio, Giulio;Murabito, Paolo;Carotenuto, Marco;Messina, Antonietta;Pisanelli, Daniela;Valenzano, Anna;Cibelli, Giuseppe;Scarinci, Alessia;Monda, Marcellino;Sessa, Francesco
10.3390/ijms21093104
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work. [Abstract]: BACKGROUND: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection s...
32,839,634
J Mol Liq
Investigating the potential antiviral activity drugs against SARS-CoV-2 by molecular docking simulation.
Recently, scary viral pneumonia is known as (COVID-19) has swept the whole world. The new virus strain designated as SARS-CoV-2 belonging to the coronavirus family. Although the current medical research directed towards the development of a novel therapeutic agent, no anti-viral drug approved until now. On the medical ...
covid-19;coronavirus;homology modeling;molecular docking;sars-cov-2
Journal Article
El-Hoshoudy, A N
10.1016/j.molliq.2020.113968
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Investigating the potential antiviral activity drugs against SARS-CoV-2 by molecular docking simulation. [Abstract]: Recently, scary viral pneumonia is known as (COVID-19) has swept the whole world. The new virus strain designated as SARS-CoV-2 belonging to the coronavirus family. Although the current medical ...
32,895,375
Nat Commun
Developing a COVID-19 mortality risk prediction model when individual-level data are not available.
At the COVID-19 pandemic onset, when individual-level data of COVID-19 patients were not yet available, there was already a need for risk predictors to support prevention and treatment decisions. Here, we report a hybrid strategy to create such a predictor, combining the development of a baseline severe respiratory inf...
Journal Article;Research Support, Non-U.S. Gov't
Barda, Noam;Riesel, Dan;Akriv, Amichay;Levy, Joseph;Finkel, Uriah;Yona, Gal;Greenfeld, Daniel;Sheiba, Shimon;Somer, Jonathan;Bachmat, Eitan;Rothblum, Guy N;Shalit, Uri;Netzer, Doron;Balicer, Ran;Dagan, Noa
10.1038/s41467-020-18297-9
[ 0, 1, 1, 0, 0, 0, 0 ]
[Title]: Developing a COVID-19 mortality risk prediction model when individual-level data are not available. [Abstract]: At the COVID-19 pandemic onset, when individual-level data of COVID-19 patients were not yet available, there was already a need for risk predictors to support prevention and treatment decisions. Her...
33,029,758
Inflammation
Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications.
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein of SARS-CoV-2 binds with angiotensin-converting enzyme 2 (ACE2) as a functional "receptor" and then enters into host cells to replicate and damage h...
covid-19;sars-cov-2;angiotensin-converting enzyme 2;cytokine storm;multiple organ failure;renin-angiotensin system
Journal Article;Review
Iwasaki, Masae;Saito, Junichi;Zhao, Hailin;Sakamoto, Atsuhiro;Hirota, Kazuyoshi;Ma, Daqing
10.1007/s10753-020-01337-3
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications. [Abstract]: The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The ...
32,476,080
J Thromb Thrombolysis
The association between treatment with heparin and survival in patients with Covid-19.
This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were u...
coronavirus infections;covid-19;heparin;mortality;pulmonary embolism;thrombosis
Journal Article;Multicenter Study
Ayerbe, Luis;Risco, Carlos;Ayis, Salma
10.1007/s11239-020-02162-z
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: The association between treatment with heparin and survival in patients with Covid-19. [Abstract]: This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients...
32,281,329
Zhongguo Zhong Yao Za Zhi
[Study on treatment of "cytokine storm" by anti-2019-nCoV prescriptions based on arachidonic acid metabolic pathway].
Since the outbreak of 2019-nCoV, the epidemic has developed rapidly and the situation is grim. LANCET figured out that the 2019-nCoV is closely related to "cytokine storm". "Cytokine storm" is an excessive immune response of the body to external stimuli such as viruses and bacteria. As the virus att...
cytokine storm;2019-ncov;arachidonic acid metabolic pathway;traditional chinese medicine;virtual screening
Journal Article
Ren, Yue;Yao, Mei-Cun;Huo, Xiao-Qian;Gu, Yu;Zhu, Wei-Xing;Qiao, Yan-Jiang;Zhang, Yan-Ling
10.19540/j.cnki.cjcmm.20200224.405
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: [Study on treatment of "cytokine storm" by anti-2019-nCoV prescriptions based on arachidonic acid metabolic pathway]. [Abstract]: Since the outbreak of 2019-nCoV, the epidemic has developed rapidly and the situation is grim. LANCET figured out that the 2019-nCoV is closely related to "cytokine storm"...
32,863,487
Physica D
New approximations, and policy implications, from a delayed dynamic model of a fast pandemic.
We study an SEIQR (Susceptible-Exposed-Infectious-Quarantined-Recovered) model due to Young et al. (2019) for an infectious disease, with time delays for latency and an asymptomatic phase. For fast pandemics where nobody has prior immunity and everyone has immunity after recovery, the SEIQR model decouples into two non...
covid-19;epidemic;long-wave solution;multiple scales;social distancing
Journal Article
Vyasarayani, C P;Chatterjee, Anindya
10.1016/j.physd.2020.132701
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: New approximations, and policy implications, from a delayed dynamic model of a fast pandemic. [Abstract]: We study an SEIQR (Susceptible-Exposed-Infectious-Quarantined-Recovered) model due to Young et al. (2019) for an infectious disease, with time delays for latency and an asymptomatic phase. For fast pandemi...
32,581,461
J Curr Glaucoma Pract
Current Glaucoma Practice: The Covid-19 Impact.
How to cite this article: Bhartiya S. Current Glaucoma Practice: The Covid-19 Impact. J Curr Glaucoma Pract 2020;14(1):1-2.
Editorial
Bhartiya, Shibal
10.5005/jp-journals-10078-1275
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Current Glaucoma Practice: The Covid-19 Impact. [Abstract]: How to cite this article: Bhartiya S. Current Glaucoma Practice: The Covid-19 Impact. J Curr Glaucoma Pract 2020;14(1):1-2. [Keywords]:
32,550,095
Cureus
Humidifier Use and Prone Positioning in a Patient with Severe COVID-19 Pneumonia and Endotracheal Tube Impaction Due to Highly Viscous Sputum.
COVID-19 can lead to severe pneumonia, requiring mechanical ventilation. While increased sputum secretion could cause airway obstruction during mechanical ventilation, there are few reported cases in the literature. We report a case of a 65-year-old man with diabetes and severe COVID-19 pneumonia requiring mechanical v...
coronavirus 2019 (covid-19);coronavirus disease 2019;covid-19 respiratory failure high altitude pulmonary edema high flow nasal cannula acute respiratory distress syndrome;invasive mechanical ventilation;key words corona;sars cov-2;sars-cov-2 (severe acute respiratory syndrome coronavirus -2);tube impaction
Case Reports
Sugimoto, Ryu;Kenzaka, Tsuneaki;Fujikawa, Moemi;Kawasaki, Satoru;Nishisaki, Hogara
10.7759/cureus.8626
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Humidifier Use and Prone Positioning in a Patient with Severe COVID-19 Pneumonia and Endotracheal Tube Impaction Due to Highly Viscous Sputum. [Abstract]: COVID-19 can lead to severe pneumonia, requiring mechanical ventilation. While increased sputum secretion could cause airway obstruction during mechanical v...
32,328,533
Glob Health Res Policy
Canada's role in strengthening global health security during the COVID-19 pandemic.
The world is confronted by the current pandemic of Corona Virus Disease (COVID-19), which is a wake-up call for all nations irrespective of their development status or geographical location. Since the start of the century we have seen five big infectious outbreaks which proved that epidemics are no more regarded as his...
covid-19;canada;coronavirus outbreak;epidemic;epidemic curve;global health security;pandemic;public health;public health emergency of international concern
Journal Article
Chattu, Vijay Kumar;Adisesh, Anil;Yaya, Sanni
10.1186/s41256-020-00146-3
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Canada's role in strengthening global health security during the COVID-19 pandemic. [Abstract]: The world is confronted by the current pandemic of Corona Virus Disease (COVID-19), which is a wake-up call for all nations irrespective of their development status or geographical location. Since the start of the c...
32,397,847
Immunotherapy
Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens.
Aim: There is a critical need for effective therapies that are immediately available to control the spread of COVID-19 disease. Material & methods: Gamunex((R))-C and Flebogamma((R)) DIF (Grifols) intravenous immunoglobulin (IVIG) products were tested using ELISA techniques for antibodies against several antigens of hu...
covid-19;sars-cov-2;antibody content;intravenous immunoglobulin
Journal Article
Diez, Jose-Maria;Romero, Carolina;Gajardo, Rodrigo
10.2217/imt-2020-0095
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens. [Abstract]: Aim: There is a critical need for effective therapies that are immediately available to control the spread of COVID-19 disease. Material & methods: Gamunex((...
32,740,678
J Med Syst
Utility of Artificial Intelligence Amidst the COVID 19 Pandemic: A Review.
The term machine learning refers to a collection of tools used for identifying patterns in data. As opposed to traditional methods of pattern identification, machine learning tools relies on artificial intelligence to map out patters from large amounts of data, can self-improve as and when new data becomes available an...
artificial intelligence;covid 19;machine learning;outcome prediction
Journal Article;Review
Bansal, Agam;Padappayil, Rana Prathap;Garg, Chandan;Singal, Anjali;Gupta, Mohak;Klein, Allan
10.1007/s10916-020-01617-3
[ 1, 1, 1, 0, 0, 1, 0 ]
[Title]: Utility of Artificial Intelligence Amidst the COVID 19 Pandemic: A Review. [Abstract]: The term machine learning refers to a collection of tools used for identifying patterns in data. As opposed to traditional methods of pattern identification, machine learning tools relies on artificial intelligence to map ou...
32,834,701
Commun Nonlinear Sci Numer Simul
On the uncertainty of real-time predictions of epidemic growths: A COVID-19 case study for China and Italy.
While COVID-19 is rapidly propagating around the globe, the need for providing real-time forecasts of the epidemics pushes fits of dynamical and statistical models to available data beyond their capabilities. Here we focus on statistical predictions of COVID-19 infections performed by fitting asymptotic distributions t...
covid-19;epidemic model;logistic model;national vs. regional diffusion
Journal Article
Alberti, Tommaso;Faranda, Davide
10.1016/j.cnsns.2020.105372
[ 0, 0, 0, 0, 0, 1, 0 ]
[Title]: On the uncertainty of real-time predictions of epidemic growths: A COVID-19 case study for China and Italy. [Abstract]: While COVID-19 is rapidly propagating around the globe, the need for providing real-time forecasts of the epidemics pushes fits of dynamical and statistical models to available data beyond th...
32,677,734
Med J Aust
Clinical presentation and management of COVID-19.
The rapid spread of severe acute respiratory syndrome coronavirus 2 led to the declaration of a global pandemic within 3 months of its emergence. The majority of patients presenting with coronavirus disease 2019 (COVID-19) experience a mild illness that can usually be managed in the community. Patients require careful ...
covid-19;clinical decision-making;epidemics;respiratory tract infections
Journal Article;Review
Thevarajan, Irani;Buising, Kirsty L;Cowie, Benjamin C
10.5694/mja2.50698
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Clinical presentation and management of COVID-19. [Abstract]: The rapid spread of severe acute respiratory syndrome coronavirus 2 led to the declaration of a global pandemic within 3 months of its emergence. The majority of patients presenting with coronavirus disease 2019 (COVID-19) experience a mild illness ...
32,791,492
J Med Internet Res
Excess Patient Visits for Cough and Pulmonary Disease at a Large US Health System in the Months Prior to the COVID-19 Pandemic: Time-Series Analysis.
BACKGROUND: Accurately assessing the regional activity of diseases such as COVID-19 is important in guiding public health interventions. Leveraging electronic health records (EHRs) to monitor outpatient clinical encounters may lead to the identification of emerging outbreaks. OBJECTIVE: The aim of this study is to inve...
covid-19;electronic health record;forecast;pandemic;prediction;time-series analysis
Journal Article;Observational Study
Elmore, Joann G;Wang, Pin-Chieh;Kerr, Kathleen F;Schriger, David L;Morrison, Douglas E;Brookmeyer, Ron;Pfeffer, Michael A;Payne, Thomas H;Currier, Judith S
10.2196/21562
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Excess Patient Visits for Cough and Pulmonary Disease at a Large US Health System in the Months Prior to the COVID-19 Pandemic: Time-Series Analysis. [Abstract]: BACKGROUND: Accurately assessing the regional activity of diseases such as COVID-19 is important in guiding public health interventions. Leveraging e...
32,799,796
BMC Gastroenterol
The aggressive surgical treatment and outcome of a colon cancer patient with COVID-19 in Wuhan, China.
BACKGROUND: Cancer patients are at increased risk of novel coronavirus disease 2019 (COVID-19). Currently, surgeries for cancer patients with COVID-19 are generally suggested to be properly delayed. CASE PRESENTATION: We presented a 69-year-old Chinese female colon cancer patient with COVID-19, the first case accepted ...
covid-19;case report;colon cancer;pathology;sars-cov-2
Case Reports;Journal Article
Gao, Jinbo;Yang, Ming;Liu, Lian;Guo, Shuang;Li, Yongfeng;Cheng, Chao
10.1186/s12876-020-01411-y
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: The aggressive surgical treatment and outcome of a colon cancer patient with COVID-19 in Wuhan, China. [Abstract]: BACKGROUND: Cancer patients are at increased risk of novel coronavirus disease 2019 (COVID-19). Currently, surgeries for cancer patients with COVID-19 are generally suggested to be properly delaye...
33,057,389
PLoS One
A bivariate prediction approach for adapting the health care system response to the spread of COVID-19.
The spread of COVID-19 implied a large and fast increase of demand for intensive care services. To face this increase in demand, health care systems need to adapt their response by increasing hospital beds, intensive care unit (ICU) capacity and by (re-)deploying doctors and other personnel. This paper proposes a forec...
Journal Article;Research Support, Non-U.S. Gov't
Berta, Paolo;Paruolo, Paolo;Verzillo, Stefano;Lovaglio, Pietro Giorgio
10.1371/journal.pone.0240150
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: A bivariate prediction approach for adapting the health care system response to the spread of COVID-19. [Abstract]: The spread of COVID-19 implied a large and fast increase of demand for intensive care services. To face this increase in demand, health care systems need to adapt their response by increasing hos...
32,567,480
New Solut
Hazard Pay for COVID-19? Yes, But It's Not a Substitute for a Living Wage and Enforceable Worker Protections.
The COVID-19 pandemic is exposing critical failures in public and occupational health in the United States. So-called hazard pay for essential workers is a necessary but insufficient response to the lack of workplace protections. The roots of these failures in the weakening of the Occupational Safety and Health Adminis...
covid-19;osha enforcement;essential workers;fissured workplace;hazard pay
Journal Article
Hecker, Steven
10.1177/1048291120933814
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Hazard Pay for COVID-19? Yes, But It's Not a Substitute for a Living Wage and Enforceable Worker Protections. [Abstract]: The COVID-19 pandemic is exposing critical failures in public and occupational health in the United States. So-called hazard pay for essential workers is a necessary but insufficient respon...
32,886,755
J Exp Med
Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients.
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways...
Journal Article;Research Support, Non-U.S. Gov't
Jouan, Youenn;Guillon, Antoine;Gonzalez, Loic;Perez, Yonatan;Boisseau, Chloe;Ehrmann, Stephan;Ferreira, Marion;Daix, Thomas;Jeannet, Robin;Francois, Bruno;Dequin, Pierre-Francois;Si-Tahar, Mustapha;Baranek, Thomas;Paget, Christophe
10.1084/jem.20200872
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. [Abstract]: COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophys...
32,453,656
JCO Oncol Pract
Management of Lung Cancer During the COVID-19 Pandemic.
Coronavirus disease 2019 (COVID-19) has had a devastating impact around the world. With high rates of transmission and no curative therapies or vaccine yet available, the current cornerstone of management focuses on prevention by social distancing. This includes decreased health care contact for patients. Patients with...
Journal Article
Singh, Aditi P;Berman, Abigail T;Marmarelis, Melina E;Haas, Andrew R;Feigenberg, Steven J;Braun, Jennifer;Ciunci, Christine A;Bauml, Joshua M;Cohen, Roger B;Kucharczuk, John C;Shulman, Lawrence N;Langer, Corey J;Aggarwal, Charu
10.1200/OP.20.00286
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: Management of Lung Cancer During the COVID-19 Pandemic. [Abstract]: Coronavirus disease 2019 (COVID-19) has had a devastating impact around the world. With high rates of transmission and no curative therapies or vaccine yet available, the current cornerstone of management focuses on prevention by social distan...
32,655,654
Drugs Context
Coronavirus disease 2019 (COVID-19): latest developments in potential treatments.
Many viral respiratory infections can cause severe acute respiratory symptoms leading to mortality and morbidity. In the spring of 2003, the severe acute respiratory syndrome (SARS) outbreak caused by SARS-CoV spread globally. In the summer of 2012, the Middle East respiratory syndrome (MERS) outbreak caused by MERS-Co...
covid-19;sars-cov-2;coronavirus;review;therapeutics;vaccines
Journal Article;Review
Hon, Kam Lun;Leung, Karen Ka Yan;Leung, Alexander Kc;Qian, Su Yun;Chan, Vivian Py;Ip, Patrick;Wong, Ian Ck
10.7573/dic.2020-4-15
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Coronavirus disease 2019 (COVID-19): latest developments in potential treatments. [Abstract]: Many viral respiratory infections can cause severe acute respiratory symptoms leading to mortality and morbidity. In the spring of 2003, the severe acute respiratory syndrome (SARS) outbreak caused by SARS-CoV spread ...
33,068,310
Int J Clin Pract
Clinical differences in chest CT characteristics between the progression and remission stages of patients with COVID-19 pneumonia.
INTRODUCTION: Computed tomography (CT) can be effective for the early screening and diagnosis of COVID-19. This study aimed to investigate the distinctive CT characteristics of two stages of the disease (progression and remission). METHODS: We included all COVID-19 patients admitted to Wenzhou Central Hospital from Jan...
Journal Article
Liao, Jie-Lan;Chen, Yu;Huang, Chong-Quan;He, Gui-Qing;Du, Ji-Cheng;Chen, Que-Lu
10.1111/ijcp.13760
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Clinical differences in chest CT characteristics between the progression and remission stages of patients with COVID-19 pneumonia. [Abstract]: INTRODUCTION: Computed tomography (CT) can be effective for the early screening and diagnosis of COVID-19. This study aimed to investigate the distinctive CT characteri...
32,898,882
Am J Perinatol
Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations.
OBJECTIVE: We aimed at reviewing the currently available guidelines and scientific recommendations regarding the neonatal in-hospital management and feeding in the light of the coronavirus disease 2019 (COVID-19) pandemic. STUDY DESIGN: We systematically searched the guideline databases, Medline, Embase, and nationale/...
Journal Article;Review
Genoni, Giulia;Conio, Alessandra;Binotti, Marco;Manzoni, Paolo;Castagno, Matteo;Rabbone, Ivana;Monzani, Alice
10.1055/s-0040-1714675
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations. [Abstract]: OBJECTIVE: We aimed at reviewing the currently available guidelines and scientific recommendations regarding the neonatal in-hospital management and feeding in the light of th...
32,971,756
Int J Environ Res Public Health
Chest CT Computerized Aided Quantification of PNEUMONIA Lesions in COVID-19 Infection: A Comparison among Three Commercial Software.
PURPOSE: To compare different commercial software in the quantification of Pneumonia Lesions in COVID-19 infection and to stratify the patients based on the disease severity using on chest computed tomography (CT) images. MATERIALS AND METHODS: We retrospectively examined 162 patients with confirmed COVID-19 infection ...
covid-19;computed tomography;computer-aided quantification
Comparative Study;Journal Article
Grassi, Roberto;Cappabianca, Salvatore;Urraro, Fabrizio;Feragalli, Beatrice;Montanelli, Alessandro;Patelli, Gianluigi;Granata, Vincenza;Giacobbe, Giuliana;Russo, Gaetano Maria;Grillo, Assunta;De Lisio, Angela;Paura, Cesare;Clemente, Alfredo;Gagliardi, Giuliano;Magliocchetti, Simona;Cozzi, Diletta;Fusco, Roberta;Belfior...
10.3390/ijerph17186914
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Chest CT Computerized Aided Quantification of PNEUMONIA Lesions in COVID-19 Infection: A Comparison among Three Commercial Software. [Abstract]: PURPOSE: To compare different commercial software in the quantification of Pneumonia Lesions in COVID-19 infection and to stratify the patients based on the disease s...
32,387,014
Encephale
[Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study].
OBJECTIVES: The ongoing COVID-19 pandemic comprises a total of more than 2,350,000 cases and 160,000 deaths. The interest in anti-coronavirus drug development has been limited so far and effective methods to prevent or treat coronavirus infections in humans are still lacking. Urgent action is needed to fight this fatal...
covid-19;chlorpromazine;clinical trial;essai clinique;repositionnement de molecules;repurposing of drugs;sars-cov-2
Journal Article
Plaze, M;Attali, D;Petit, A-C;Blatzer, M;Simon-Loriere, E;Vinckier, F;Cachia, A;Chretien, F;Gaillard, R
10.1016/j.encep.2020.04.010
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: [Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study]. [Abstract]: OBJECTIVES: The ongoing COVID-19 pandemic comprises a total of more than 2,350,000 cases and 160,000 deaths. The interest in anti-coronavirus drug development has been limited so far and effective methods to prevent or treat...
32,555,723
PLoS One
Involuntary ambulatory triage during the COVID-19 pandemic - A neurosurgical perspective.
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge to health-care systems around the world. As approximately one-third of the world s population is living under "lockdown" conditions, medical resources are being reallocated and hospital admissions are limited to emergencies. W...
Journal Article
Krenzlin, Harald;Bettag, Christoph;Rohde, Veit;Ringel, Florian;Keric, Naureen
10.1371/journal.pone.0234956
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Involuntary ambulatory triage during the COVID-19 pandemic - A neurosurgical perspective. [Abstract]: BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge to health-care systems around the world. As approximately one-third of the world s population is living under "lock...
33,050,924
Trials
Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65...
OBJECTIVES: To assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged 65 or more with recent symptomatic SARS-CoV-2 infection (COVID-19) and no criteria for hospitalisation. TRIAL DESIGN: Phase III, multi-arm (5) and multi-stage (MAMS), randomized, open-label controlled sup...
Clinical Trial, Phase III;Letter;Randomized Controlled Trial
Duvignaud, Alexandre;Lhomme, Edouard;Pistone, Thierry;Onaisi, Racha;Sitta, Remi;Journot, Valerie;Nguyen, Duc;Peiffer-Smadja, Nathan;Cremer, Antoine;Bouchet, Stephane;Darnaud, Thomas;Poitrenaud, Delphine;Piroth, Lionel;Binquet, Christine;Michel, Jean-Francois;Lefevre, Benjamin;Lebeaux, David;Lebel, Josselin;Dupouy, Juli...
10.1186/s13063-020-04619-1
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatient...
32,719,731
J Pharm Policy Pract
COVID-19 therapeutics: how to sow confusion and break public trust during international public health emergencies.
Since SARS-CoV2 was declared a Public Health Emergency of International Concern, those tasked with the stewardship of public health at a global, regional, and local level-policymakers, politicians, scientists, drug regulators, health officials, professional associations, journal editors, publishers, and clinicians-have...
Journal Article
Singh, Jerome Amir;Ravinetto, Rafaella
10.1186/s40545-020-00244-0
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: COVID-19 therapeutics: how to sow confusion and break public trust during international public health emergencies. [Abstract]: Since SARS-CoV2 was declared a Public Health Emergency of International Concern, those tasked with the stewardship of public health at a global, regional, and local level-policymakers,...
32,754,113
Front Neurol
Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series.
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily causes respiratory illness. However, neurological sequelae from novel coronavirus disease 2019 (COVID-19) can occur. Patients with neurological conditions may be at higher risk of developing worsening of their underlying problem. Here we ...
covid-19;inpatient consults;neurology;novel coronavirus;severe acute respiratory syndrome coronavirus 2
Journal Article
Radmard, Sara;Epstein, Samantha E;Roeder, Hannah J;Michalak, Andrew J;Shapiro, Steven D;Boehme, Amelia;Wilson, Tommy J;Duran, Juan C;Bain, Jennifer M;Willey, Joshua Z;Thakur, Kiran T
10.3389/fneur.2020.00805
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series. [Abstract]: Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily causes respiratory illness. However, neurological sequelae from novel coronavirus disease 2019 ...
32,592,406
Eur J Immunol
Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults.
Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1beta in adults with COVID-19, but not in children. In addition, pla...
ccl5/rantes;covid-19;cxcl9/mig;sars-cov-2;t-cell activation
Letter;Research Support, Non-U.S. Gov't
Moratto, Daniele;Giacomelli, Mauro;Chiarini, Marco;Savare, Lucia;Saccani, Barbara;Motta, Mario;Timpano, Silviana;Poli, Piercarlo;Paghera, Simone;Imberti, Luisa;Cannizzo, Stefania;Quiros-Roldan, Eugenia;Marchetti, Giulia;Badolato, Raffaele
10.1002/eji.202048724
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults. [Abstract]: Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 a...
32,821,783
J Patient Exp
Medical Abortion Care During a Pandemic.
In keeping with federal policy, our state's laws do not permit medical abortion via telemedicine, not even during the coronavirus disease 2019 (COVID-19) outbreak, a decision that endangers the lives of women, clinical staff, nurses, and doctors. It also ties dedicated professionals to the clinic instead of being avail...
covid-19;medical abortion;telehealth;telemedicine;women's health
Journal Article
Baill, I Cori
10.1177/2374373520929923
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Medical Abortion Care During a Pandemic. [Abstract]: In keeping with federal policy, our state's laws do not permit medical abortion via telemedicine, not even during the coronavirus disease 2019 (COVID-19) outbreak, a decision that endangers the lives of women, clinical staff, nurses, and doctors. It also tie...
32,571,606
Arch Med Res
Amantadine Treatment for People with COVID-19.
SARS-Cov-2, whose symptoms include difficulty swallowing, coughing, diarrhea, and breathing failure, has caused the loss of many lives around the world. In the absence of a vaccine or medication to help prevent or decrease the effects of the disease, we suggest that amantadine may reduce the effects of COVID-19.
amantadine;covid-19;drugs
Journal Article
Araujo, Ramiro;Aranda-Martinez, Jose Dolores;Aranda-Abreu, Gonzalo Emiliano
10.1016/j.arcmed.2020.06.009
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Amantadine Treatment for People with COVID-19. [Abstract]: SARS-Cov-2, whose symptoms include difficulty swallowing, coughing, diarrhea, and breathing failure, has caused the loss of many lives around the world. In the absence of a vaccine or medication to help prevent or decrease the effects of the disease, w...
32,519,165
J Thromb Thrombolysis
Incidence and consequences of systemic arterial thrombotic events in COVID-19 patients.
A high incidence of thrombotic events, particularly deep vein thrombosis and pulmonary embolism, has been clearly documented in COVID-19 patients. In addition, small series of patients with coronary, cerebrovascular and peripheral arterial thrombotic events have also been reported, but their true incidence and conseque...
acute coronary syndrome;covid-19;peripheral arterial disease;stroke;thrombosis
Journal Article
Cantador, Estefania;Nunez, Alberto;Sobrino, Pilar;Espejo, Victoria;Fabia, Lucia;Vela, Lydia;de Benito, Luis;Botas, Javier
10.1007/s11239-020-02176-7
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Incidence and consequences of systemic arterial thrombotic events in COVID-19 patients. [Abstract]: A high incidence of thrombotic events, particularly deep vein thrombosis and pulmonary embolism, has been clearly documented in COVID-19 patients. In addition, small series of patients with coronary, cerebrovasc...
32,956,615
Lancet Child Adolesc Health
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process.
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children with PIMS-TS. A three-phase online Delphi ...
Journal Article;Research Support, Non-U.S. Gov't;Review
Harwood, Rachel;Allin, Benjamin;Jones, Christine E;Whittaker, Elizabeth;Ramnarayan, Padmanabhan;Ramanan, Athimalaipet V;Kaleem, Musa;Tulloh, Robert;Peters, Mark J;Almond, Sarah;Davis, Peter J;Levin, Michael;Tometzki, Andrew;Faust, Saul N;Knight, Marian;Kenny, Simon
10.1016/S2352-4642(20)30304-7
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. [Abstract]: Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was firs...
32,286,947
Curr Cancer Drug Targets
COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide.
The outbreak of COVID-19 due to SARS-CoV-2 originally emerged in Wuhan in December 2019. As of March 22, 2020, the disease spread to 186 countries, with at least 305,275 confirmed cases. Although there has been a decline in the spread of the disease in China, the prevalence of COVID-19 around the world remains serious ...
2019-ncov;covid-19;sars-cov-2;coronavirus;pneumonia outbreak
Journal Article;Review
Liu, Ning-Ning;Tan, Jing-Cong;Li, Jingquan;Li, Shenghui;Cai, Yong;Wang, Hui
10.2174/1568009620666200414151419
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: COVID-19 Pandemic: Experiences in China and Implications for its Prevention and Treatment Worldwide. [Abstract]: The outbreak of COVID-19 due to SARS-CoV-2 originally emerged in Wuhan in December 2019. As of March 22, 2020, the disease spread to 186 countries, with at least 305,275 confirmed cases. Although th...
33,062,897
J Med Educ Curric Dev
The Radiology Resident Experience at a Large Tertiary Care Hospital During the COVID-19 Pandemic.
The COVID-19 pandemic has created unprecedented challenges in healthcare including pressure to provide efficient and timely patient care while maintaining a safe environment for physicians and staff. Radiology plays a vital role as part of a multidisciplinary team in the care of these patients. We address the experienc...
covid-19;ct;radiology;radiology residency;virtual learning;workflow
Journal Article
Holten, John;Ramakrishnan, Karthika;Charlie, Abbas;Standiford, Taylor;Maresky, Hillel;Cohen, Gary;Kumaran, Maruti
10.1177/2382120520963036
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: The Radiology Resident Experience at a Large Tertiary Care Hospital During the COVID-19 Pandemic. [Abstract]: The COVID-19 pandemic has created unprecedented challenges in healthcare including pressure to provide efficient and timely patient care while maintaining a safe environment for physicians and staff. R...
32,315,079
Pediatr Dermatol
Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue?
It has been reported that the novel coronavirus disease (COVID-19) may be associated with a papulovesicular skin eruption predominantly involving the trunk. We hereby present a case of COVID-19-associated varicella-like exanthem in an 8-year-old girl with mild systemic symptoms.
covid-19;sars-cov-2;coronavirus;infection;pediatric;viral exanthem
Case Reports;Journal Article
Genovese, Giovanni;Colonna, Cristiana;Marzano, Angelo V
10.1111/pde.14201
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue? [Abstract]: It has been reported that the novel coronavirus disease (COVID-19) may be associated with a papulovesicular skin eruption predominantly involving the trunk. We hereby present a case of COVID-19-associated var...
33,039,257
Early Hum Dev
COVID-19: Mathematical estimation of delay to deaths in relation to upsurges in positive rates.
INTRODUCTION: The world continues in the grip of the COVID-19 pandemic. Widespread public health measures and travel restrictions have dampened viral spread but outbreaks are expected as restrictions are raised. This study was carried out in order to devise an approach that may help to predict deaths based on upsurges ...
coronavirus;pandemics;population health;population surveillance;prevention
Retraction of Publication
Grech, Victor;Scherb, Hagen
10.1016/j.earlhumdev.2020.105210
[ 0, 0, 1, 0, 0, 1, 0 ]
[Title]: COVID-19: Mathematical estimation of delay to deaths in relation to upsurges in positive rates. [Abstract]: INTRODUCTION: The world continues in the grip of the COVID-19 pandemic. Widespread public health measures and travel restrictions have dampened viral spread but outbreaks are expected as restrictions are...
32,696,312
Acta Neurol Belg
Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain-Barre syndrome.
In December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia from Wuhan, China, aroused worldwide concern due to an escalating outbreak in all the countries in the world. Coronavirus belongs to a family of single-stranded RNA viruses, which includes severe acute respiratory syndrome (SARS-CoV) and Middle ...
acute axonal;acute respiratory distress (ards);covid-19;demyelinating neuropathy;guillain-barre syndrome;mers-cov;sars-cov
Journal Article;Review
Galassi, Giuliana;Marchioni, Alessandro
10.1007/s13760-020-01421-3
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain-Barre syndrome. [Abstract]: In December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia from Wuhan, China, aroused worldwide concern due to an escalating outbreak in all the countries in the world. Coronavirus belong...
32,681,409
Community Ment Health J
Implementing COVID-19 Mitigation in the Community Mental Health Setting: March 2020 and Lessons Learned.
In March 2020, at the beginning of the COVID-19 pandemic, state-funded community mental health service programs (CMHSP) in Michigan, organized into 10 regions known as a "Prepaid Inpatient Health Plan" (PIHP), grappled with the task of developing a modified plan of operations, while complying with mitigation and social...
behavioral health;covid;covid-19;community mental health;community mental health and covid-19;coronavirus;mental and physical comorbidities and covid-19;mental health;psychiatry;telehealth guidelines
Journal Article
Alavi, Zakia;Haque, Raza;Felzer-Kim, Isabella Theresa;Lewicki, Todd;Haque, Ali;Mormann, Meaghan
10.1007/s10597-020-00677-6
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Implementing COVID-19 Mitigation in the Community Mental Health Setting: March 2020 and Lessons Learned. [Abstract]: In March 2020, at the beginning of the COVID-19 pandemic, state-funded community mental health service programs (CMHSP) in Michigan, organized into 10 regions known as a "Prepaid Inpatient Healt...
32,776,534
J Med Virol
Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS-CoV-2 infection: A retrospective cohort study.
As it has been shown that lopinavir (LPV) and hydroxychloroquine (HCQ) have in vitro activity against coronaviruses, they were used to treat COVID-19 during the first wave of the epidemic in Lombardy, Italy. To compare the rate of clinical improvement between those who started LPV/ritonavir (LPV/r)+HCQ within 5 days of...
covid-19;antiviral treatment;early;hydroxychloroquine;lopinavir;mortality
Journal Article
Giacomelli, Andrea;Pagani, Gabriele;Ridolfo, Anna L;Oreni, Letizia;Conti, Federico;Pezzati, Laura;Bradanini, Lucia;Casalini, Giacomo;Bassoli, Cinzia;Morena, Valentina;Passerini, Simone;Rizzardini, Giuliano;Cogliati, Chiara;Ceriani, Elisa;Colombo, Riccardo;Rusconi, Stefano;Gervasoni, Cristina;Cattaneo, Dario;Antinori, S...
10.1002/jmv.26407
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Early administration of lopinavir/ritonavir plus hydroxychloroquine does not alter the clinical course of SARS-CoV-2 infection: A retrospective cohort study. [Abstract]: As it has been shown that lopinavir (LPV) and hydroxychloroquine (HCQ) have in vitro activity against coronaviruses, they were used to treat ...
32,324,118
Emerg Infect Dis
Population-Based Estimates of Chronic Conditions Affecting Risk for Complications from Coronavirus Disease, United States.
We estimated that 45.4% of US adults are at increased risk for complications from coronavirus disease because of cardiovascular disease, diabetes, respiratory disease, hypertension, or cancer. Rates increased by age, from 19.8% for persons 18-29 years of age to 80.7% for persons >80 years of age, and varied by state, r...
covid-19;sars-cov-2;united states;chronic conditions;complications;coronavirus disease;infection;population-based estimates;respiratory infections;risk factors;severe acute respiratory syndrome coronavirus 2;viruses;zoonoses
Journal Article;Research Support, U.S. Gov't, P.H.S.
Adams, Mary L;Katz, David L;Grandpre, Joseph
10.3201/eid2608.200679
[ 0, 0, 0, 0, 0, 1, 0 ]
[Title]: Population-Based Estimates of Chronic Conditions Affecting Risk for Complications from Coronavirus Disease, United States. [Abstract]: We estimated that 45.4% of US adults are at increased risk for complications from coronavirus disease because of cardiovascular disease, diabetes, respiratory disease, hyperten...
32,953,843
World J Clin Cases
Complexities of diagnosis and management of COVID-19 in autoimmune diseases: Potential benefits and detriments of immunosuppression.
Recent advances in our understanding of coronavirus disease 2019 (COVID-19) and the associated acute respiratory distress syndrome might approximate the cytokine release syndrome of severe immune-mediated disease. Importantly, this presumption provides the rationale for utilization of therapy, until recently reserved m...
autoimmune diseases;autoimmunity;covid-19;coronavirus;cross reactions;serologic tests
Journal Article;Review
Georgiev, Tsvetoslav;Angelov, Alexander Krasimirov
10.12998/wjcc.v8.i17.3669
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Complexities of diagnosis and management of COVID-19 in autoimmune diseases: Potential benefits and detriments of immunosuppression. [Abstract]: Recent advances in our understanding of coronavirus disease 2019 (COVID-19) and the associated acute respiratory distress syndrome might approximate the cytokine rele...
33,071,142
Sci Total Environ
WITHDRAWN: Can Traditional Chinese Medicine provide insights into controlling the COVID-19 pandemic: Serpentinization-induced lithospheric long-wavelength magnetic anomalies in Proterozoic bedrocks in a weakened geomagnetic field mediate the aberrant transformation of biogenic molecules in COVID-19 via magnetic catalys...
This article has been withdrawn at the request of the authors and the editors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Retraction of Publication
Bility, Moses Turkle;Agarwal, Yash;Ho, Sara;Castronova, Isabella;Beatty, Cole;Biradar, Shivkumar;Narala, Vanshika;Periyapatna, Nivitha;Chen, Yue;Nachega, Jean
10.1016/j.scitotenv.2020.142830
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: WITHDRAWN: Can Traditional Chinese Medicine provide insights into controlling the COVID-19 pandemic: Serpentinization-induced lithospheric long-wavelength magnetic anomalies in Proterozoic bedrocks in a weakened geomagnetic field mediate the aberrant transformation of biogenic molecules in COVID-19 via magneti...
32,504,213
Int Orthop
Risk of a second wave of Covid-19 infections: using artificial intelligence to investigate stringency of physical distancing policies in North America.
PURPOSE: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy contexts has a renewed sense of urgency. Moreover, there is a need for a multidimensional county-level approach to monitor the second wave of covid-19 in the USA. METHOD: We use ...
artificial intelligence;bayesian (sir);covid-19;kalman filter;machine learning
Journal Article
Vaid, Shashank;McAdie, Aaron;Kremer, Ran;Khanduja, Vikas;Bhandari, Mohit
10.1007/s00264-020-04653-3
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Risk of a second wave of Covid-19 infections: using artificial intelligence to investigate stringency of physical distancing policies in North America. [Abstract]: PURPOSE: Accurately forecasting the occurrence of future covid-19-related cases across relaxed (Sweden) and stringent (USA and Canada) policy conte...
32,895,779
J Cell Commun Signal
Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets.
In the past two decades, two beta-coronaviruses, severe acute respiratory syndrome-related coronavirus (SARS-CoV-1) and the Middle East respiratory syndrome-related coronavirus (MERS-CoV), have infected approximately 8000 and 2500 across the globe, respectively (de Wit et al. 2016; Amanat and Krammer 2020). The current...
interferon regulator factors (irfs);sars-cov-2;tocilizumab
Journal Article
Thoutam, Akshaya;Breitzig, Mason;Lockey, Richard;Kolliputi, Narasaiah
10.1007/s12079-020-00574-3
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets. [Abstract]: In the past two decades, two beta-coronaviruses, severe acute respiratory syndrome-related coronavirus (SARS-CoV-1) and the Middle East respiratory syndrome-related coronavirus (MERS-CoV), have infected app...
32,501,801
J Med Internet Res
Internet Use, Risk Awareness, and Demographic Characteristics Associated With Engagement in Preventive Behaviors and Testing: Cross-Sectional Survey on COVID-19 in the United States.
BACKGROUND: During the coronavirus disease (COVID-19) pandemic, engagement in preventive behaviors and getting tested for the virus play a crucial role in protecting people from contracting the new coronavirus. OBJECTIVE: This study aims to examine how internet use, risk awareness, and demographic characteristics are a...
covid-19;coronavirus;online health information;preventive behaviors;risk awareness;testing
Journal Article
Li, Siyue;Feng, Bo;Liao, Wang;Pan, Wenjing
10.2196/19782
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Internet Use, Risk Awareness, and Demographic Characteristics Associated With Engagement in Preventive Behaviors and Testing: Cross-Sectional Survey on COVID-19 in the United States. [Abstract]: BACKGROUND: During the coronavirus disease (COVID-19) pandemic, engagement in preventive behaviors and getting teste...
32,335,067
Chest
Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report.
BACKGROUND: The risks from potential exposure to coronavirus disease 2019 (COVID-19), and resource reallocation that has occurred to combat the pandemic, have altered the balance of benefits and harms that informed current (pre-COVID-19) guideline recommendations for lung cancer screening and lung nodule evaluation. Co...
covid-19;consensus statement;lung cancer screening;lung nodule
Practice Guideline
Mazzone, Peter J;Gould, Michael K;Arenberg, Douglas A;Chen, Alexander C;Choi, Humberto K;Detterbeck, Frank C;Farjah, Farhood;Fong, Kwun M;Iaccarino, Jonathan M;Janes, Samuel M;Kanne, Jeffrey P;Kazerooni, Ella A;MacMahon, Heber;Naidich, David P;Powell, Charles A;Raoof, Suhail;Rivera, M Patricia;Tanner, Nichole T;Tanoue,...
10.1016/j.chest.2020.04.020
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report. [Abstract]: BACKGROUND: The risks from potential exposure to coronavirus disease 2019 (COVID-19), and resource reallocation that has occurred to combat the pandemic, have altered the balance of benefit...
32,838,101
Geohealth
The silver lining of COVID-19: estimation of short-term health impacts due to lockdown in the Yangtze River Delta region, China.
The outbreak of COVID-19 in China has led to massive lockdowns in order to reduce the spread of the epidemic and control human-to-human transmission. Subsequent reductions in various anthropogenic activities have led to improved air quality during the lockdown. In this study, we apply a widely used exposure-response fu...
covid-19;pm2.5;premature mortality;yangtze river delta
Journal Article
Huang, Ling;Liu, Ziyi;Li, Hongli;Wang, Yangjun;Li, Yumin;Zhu, Yonghui;Ooi, Maggie Chel Gee;An, Jing;Shang, Yu;Zhang, Dongping;Chan, Andy;Li, Li
10.1029/2020GH000272
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: The silver lining of COVID-19: estimation of short-term health impacts due to lockdown in the Yangtze River Delta region, China. [Abstract]: The outbreak of COVID-19 in China has led to massive lockdowns in order to reduce the spread of the epidemic and control human-to-human transmission. Subsequent reduction...
32,708,319
Genes (Basel)
Computational Analysis of the Global Effects of Ly6E in the Immune Response to Coronavirus Infection Using Gene Networks.
Gene networks have arisen as a promising tool in the comprehensive modeling and analysis of complex diseases. Particularly in viral infections, the understanding of the host-pathogen mechanisms, and the immune response to these, is considered a major goal for the rational design of appropriate therapies. For this reaso...
data mining;gene co-expression network;immune response;murine coronavirus;systems biology;viral infection
Journal Article
Delgado-Chaves, Fernando M;Gomez-Vela, Francisco;Divina, Federico;Garcia-Torres, Miguel;Rodriguez-Baena, Domingo S
10.3390/genes11070831
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Computational Analysis of the Global Effects of Ly6E in the Immune Response to Coronavirus Infection Using Gene Networks. [Abstract]: Gene networks have arisen as a promising tool in the comprehensive modeling and analysis of complex diseases. Particularly in viral infections, the understanding of the host-pat...
32,628,143
Anatol J Cardiol
Emerging mechanisms for the new coronavirus-related myocardial injury and ischemia: A review of the literature.
A history of cardiovascular comorbidity or experiencing acute cardiac injury during the coronavirus disease 2019 is accompanied by a poor prognosis. Also, it seems myocardial ischemia (or infarction) accounts for a major part of the cardiac involvement observed in this disease. Therefore, particular consideration is ne...
Journal Article;Review
Hatami, Farbod;Valizadeh, Niloufar;Ansari Ramandi, Mohammad Mostafa
10.14744/AnatolJCardiol.2020.68166
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: Emerging mechanisms for the new coronavirus-related myocardial injury and ischemia: A review of the literature. [Abstract]: A history of cardiovascular comorbidity or experiencing acute cardiac injury during the coronavirus disease 2019 is accompanied by a poor prognosis. Also, it seems myocardial ischemia (or...
32,723,229
Comb Chem High Throughput Screen
Could Targeting HMGB1 be useful for the Clinical Management of COVID-19 Infection?
Since the high mobility group box-1 (HMGB1) molecule had been recognized as a pro-inflammatory cytokine, which mediates endotoxin lethality of mice; there have been lots of papers about targeting the HMGB1 within the contexts of infection, inflammation, and cancer. The pathogenic impact of HMGB1 to the severe acute res...
covid-19;high mobility group box-1 (hmgb1);clinical trial.;drug repurposing;herbal medicinal products;infection
Journal Article
Celebier, Mustafa;Haznedaroglu, Ibrahim Celalettin
10.2174/1386207323999200728114927
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Could Targeting HMGB1 be useful for the Clinical Management of COVID-19 Infection? [Abstract]: Since the high mobility group box-1 (HMGB1) molecule had been recognized as a pro-inflammatory cytokine, which mediates endotoxin lethality of mice; there have been lots of papers about targeting the HMGB1 within the...
32,373,409
Cureus
Frequent Hand Washing for COVID-19 Prevention Can Cause Hand Dermatitis: Management Tips.
Coronavirus disease 2019 (COVID-19) continues to spread globally, outpacing the capacity and resources of health systems worldwide. A therapeutic vaccine is not yet on the rise, and preventive measures are the current approach to restraint the transmission of cases. As the virus is highly contagious via respiratory rou...
contact dermatitis;covid-19;hand dermatitis;prevention
Journal Article;Review
Beiu, Cristina;Mihai, Mara;Popa, Liliana;Cima, Luiza;Popescu, Marius N
10.7759/cureus.7506
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Frequent Hand Washing for COVID-19 Prevention Can Cause Hand Dermatitis: Management Tips. [Abstract]: Coronavirus disease 2019 (COVID-19) continues to spread globally, outpacing the capacity and resources of health systems worldwide. A therapeutic vaccine is not yet on the rise, and preventive measures are the...
32,862,493
Int J Health Plann Manage
Can management decentralisation resolve challenges faced by healthcare service delivery organisations? Findings for managers and researchers from a scoping review.
PURPOSE: Decentralisation of decision-making from central to lower level organisation has been proposed as a way to increase innovation and make services more responsive to local needs. The purpose of this study was to discover research that can contribute to understanding decentralisation as one strategy for resolving...
decentralisation;delivery of healthcare;management;organisation;primary care
Journal Article;Review
Ohrling, Mikael;Ovretveit, John;Brommels, Mats
10.1002/hpm.3058
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Can management decentralisation resolve challenges faced by healthcare service delivery organisations? Findings for managers and researchers from a scoping review. [Abstract]: PURPOSE: Decentralisation of decision-making from central to lower level organisation has been proposed as a way to increase innovation...
32,838,158
SN Compr Clin Med
Multiple Acute Ischemic Strokes in a COVID-19 Patient: a Case Report.
We describe a case of a 47-year-old Italian, immunocompromised, and obese woman infected by COVID-19 presenting with fever (39.6 degrees C) and respiratory symptoms. Neurological examination was normal. Chest CT findings consist of bilateral interstitial pneumonia (visual score extension: 30%). The patient was treated ...
antiphospholipid syndrome;covid-19;case report;obesity;stroke
Journal Article
Cerasti, Davide;Ormitti, Francesca;Pardatscher, Stefano;Malchiodi, Laura;Picetti, Edoardo;Menozzi, Roberto;Rossi, Sandra
10.1007/s42399-020-00388-9
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Multiple Acute Ischemic Strokes in a COVID-19 Patient: a Case Report. [Abstract]: We describe a case of a 47-year-old Italian, immunocompromised, and obese woman infected by COVID-19 presenting with fever (39.6 degrees C) and respiratory symptoms. Neurological examination was normal. Chest CT findings consist ...
32,604,125
Clin Nucl Med
Lung Scintigraphy Imaging Features in a Young Patient With COVID-19.
A 31-year-old man developed diarrhea, fatigue, and intermittent fever for 2 weeks. The past few days he had experienced increasing dyspnea and dry cough. Ambulatory reverse transcriptase-polymerase chain reaction testing was positive for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Because of elevated ...
Case Reports;Journal Article
Goetz, Christian;Fassbender, Thomas F;Meyer, Philipp T
10.1097/RLU.0000000000003196
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Lung Scintigraphy Imaging Features in a Young Patient With COVID-19. [Abstract]: A 31-year-old man developed diarrhea, fatigue, and intermittent fever for 2 weeks. The past few days he had experienced increasing dyspnea and dry cough. Ambulatory reverse transcriptase-polymerase chain reaction testing was posit...
32,878,480
Am J Physiol Lung Cell Mol Physiol
Elevated FiO2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium.
The severity of coronavirus disease 2019 (COVID-19) is linked to an increasing number of risk factors, including exogenous (environmental) stimuli such as air pollution, nicotine, and cigarette smoke. These three factors increase the expression of angiotensin I converting enzyme 2 (ACE2), a key receptor involved in the...
covid-19;fio2;sars-cov-2;tmprss;hyperoxia
Journal Article;Research Support, Non-U.S. Gov't
Myti, Despoina;Gunjak, Misa;Casado, Francisco;Khaghani Raziabad, Solmaz;Nardiello, Claudio;Vadasz, Istvan;Herold, Susanne;Pryhuber, Gloria;Seeger, Werner;Morty, Rory E
10.1152/ajplung.00345.2020
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Elevated FiO2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium. [Abstract]: The severity of coronavirus disease 2019 (COVID-19) is linked to an increasing number of risk factors, including exogenous (environmental) stimuli such as air pollution, nicotine, and cigarette smoke. These t...
32,253,226
Sci Transl Med
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Here, we show that the ribonucleoside analog beta-d-N(4)-hydroxycytidine (NHC; EIDD-1931) has broad-spectrum antiviral activity agains...
Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Sheahan, Timothy P;Sims, Amy C;Zhou, Shuntai;Graham, Rachel L;Pruijssers, Andrea J;Agostini, Maria L;Leist, Sarah R;Schafer, Alexandra;Dinnon, Kenneth H 3rd;Stevens, Laura J;Chappell, James D;Lu, Xiaotao;Hughes, Tia M;George, Amelia S;Hill, Collin S;Montgomery, Stephanie A;Brown, Ariane J;Bluemling, Gregory R;Natchus, ...
10.1126/scitranslmed.abb5883
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. [Abstract]: Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, t...