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the biogenesis of biological membranes that delineate the cell surface or act as intracellular space partition is a fundamental biological process and a remarkable evolutionary achievement .
the hydrophobic barrier of membranes is comprised of fatty acid ( fa)-derived acyl - chains , typically 16 or 18 carbon atoms in ... | summarymembrane phospholipids typically contain fatty acids ( fas ) of 16 and 18 carbon atoms .
this particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues . here
, we sho... | Introduction
Results
Discussion
Experimental Procedures | the hydrophobic barrier of membranes is comprised of fatty acid ( fa)-derived acyl - chains , typically 16 or 18 carbon atoms in length ; these fas are synthesized in a cyclic series of reactions by the multifunctional fa synthase ( fas ) complex by the addition of c2 units that are derived from malonyl - coenzyme a ( ... | [
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the online version of this article ( doi:10.1007/s10822 - 011 - 9519 - 9 ) contains supplementary material , which is available to authorized users .
life expectancy of man , and especially man in the western world , increased by more than 2 days per week for the whole previous century . much of this dramatic increase... | in its first 25 years jcamd has been disseminating a large number of techniques aimed at finding better medicines faster .
these include genetic algorithms , comfa , qsar , structure based techniques , homology modelling , high throughput screening , combichem , and dozens more that were a hype in their time and th... | Electronic supplementary material
Introduction
A brief history of tools
Where do we stand today?
Dealing with data, information, and knowledge: from hype to hope?
Electronic supplementary material | the online version of this article ( doi:10.1007/s10822 - 011 - 9519 - 9 ) contains supplementary material , which is available to authorized users . life expectancy of man , and especially man in the western world , increased by more than 2 days per week for the whole previous century . much of this dramatic increase... | [
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our current picture of cell nuclear function is shifting from the idea of fully assembled molecular complexes towards molecules freely roaming in nuclear space ( pombo and cook 1996 ; phair and misteli 2000 ; bentley 2002 ) . here , transient interactions ( protein protein , protein dna , and protein rna ) result ... | cellular life can be described as a dynamic equilibrium of a highly complex network of interacting molecules .
for this reason , it is no longer sufficient to only know the identity of the participants in a cellular process , but questions such as where , when , and for how long also have to be addressed to unders... | Introduction
Observing single molecules in the nucleus, a possibility?
Nuclear mobility as seen by fluorescence correlation spectroscopy
Single RNA tracking in the nucleus
Single protein tracking in the nucleus
Imaging HIV in the living cella perspective
The life cycle of HIV | here , transient interactions ( protein protein , protein dna , and protein rna ) result in a stochastic but directional progression of multi - scale and multi - player processes ( elf et al . while this change in paradigm challenges our view of the composition of multi - protein complexes , it also raises questions... | [
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"liver cancer is a significant worldwide health problem and is the sixth most frequently diagnosed c(...TRUNCATED) | " objectivethe aim of this study was to assess serum levels of presurgical -fetoprotein ( afp ) and (...TRUNCATED) | "Introduction\nPatients and methods\nStudy population and data collections\nLiver transplantation su(...TRUNCATED) | "to date\n, the milan criteria have been adopted by the united network of organ sharing ( unos ) as (...TRUNCATED) | [0,0,0,0,0,1,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0(...TRUNCATED) |
"biddi making is a skilled job in which tobacco is rolled in a processed kendu leaf and tied with a (...TRUNCATED) | " intorduction : the tobacco dusts get air borne during biddi making and it is inhaled by the biddi (...TRUNCATED) | "INTRODUCTION\nMATERIALS AND METHODS\nMedical study\nRESULTS AND DISCUSSION\nMedical study\nPulmonar(...TRUNCATED) | "the tobacco and the leaves were kept on the lap of the biddi binders and it is very much close to t(...TRUNCATED) | [0,0,0,0,0,0,0,1,0,0,1,1,1,1,1,0,1,1,0,0,1,0,0,1,1,1,1,0,1,1,0,0,1,0,0,1,1,1,1,1,1,1,1,0,1,1,1,0,0,1(...TRUNCATED) |
"techniques \n have been prevalently employed for the identification and relative / absolute \n quan(...TRUNCATED) | " the \n rapidly expanding availability of high - resolution mass spectrometry \n has substantially (...TRUNCATED) | Introduction
Materials and Methods
Results and Discussion
Conclusions
Data Sharing | "lc ms - based quantification approaches \n can be roughly divided into two main categories : ( i )(...TRUNCATED) | [0,1,1,1,1,0,1,0,0,1,0,0,1,0,1,0,1,1,1,0,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,1,1,1,0,1,1,0,0,0(...TRUNCATED) |
"inflammatory bowel disease ( ibd ) is a chronic inflammation of the gastrointestinal tract thought (...TRUNCATED) | " transforming growth factor ( tgf- ) is a multifunctional cytokine recognized as an important regu(...TRUNCATED) | 1. Introduction
2. Materials and Methods
3. Results
4. Discussion and Conclusions | "inflammatory bowel disease ( ibd ) is a chronic inflammation of the gastrointestinal tract thought (...TRUNCATED) | [1,0,0,0,0,0,0,1,0,1,1,1,0,0,1,1,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,0,1,1,1,0,0,0,0,0,1,1,0,0,0,1(...TRUNCATED) |
"enzymatic proteins can exhibit abnormal \n activity in a wide variety \n of diseases such as cancer(...TRUNCATED) | " many diseases can be characterized \n by the abnormal activity exhibited \n by various biomolecule(...TRUNCATED) | "Introduction\nProtease-responsive nanomaterial systems\nfor therapeutics\nProtease-responsive nanom(...TRUNCATED) | "enzymatic proteins can exhibit abnormal \n activity in a wide variety \n of diseases such as cancer(...TRUNCATED) | [1,0,0,0,1,0,0,0,1,0,0,1,0,0,0,1,0,0,0,0,1,0,1,0,1,0,1,1,1,1,0,0,0,1,0,1,0,0,0,1,0,0,0,0,0,1,1,0,0,1(...TRUNCATED) |
"one of the major problems that humans face as we enter the twenty - first century is how to feed an(...TRUNCATED) | " the completion of the arabidopsis thaliana ( mustard weed ) genome sequence constitutes a major br(...TRUNCATED) | "Historical perspective\nThe \nThe sequencing strategy\nThe DNA molecules\nThe proteome\nThe future\(...TRUNCATED) | "one of the major problems that humans face as we enter the twenty - first century is how to feed an(...TRUNCATED) | [1,1,1,1,1,0,1,1,1,0,1,0,1,1,1,1,1,1,1,0,1,1,1,1,0,1,1,1,1,1,0,1,0,1,0,1,0,1,1,1,1,1,1,1,0,1,1,1,0,1(...TRUNCATED) |
"haruta \n et al . discovered some 20 years ago that gold known \n for its inert nature in the bulk(...TRUNCATED) | " adsorption and coadsorption of carbon \n monoxide and oxygen on different \n types of au clusters (...TRUNCATED) | "Introduction\nExperiment\nAdsorption of CO on Clean and Carburized W(110)\nAdsorption\nof CO on Au-(...TRUNCATED) | "in the present work we study the adsorption of carbon monoxide \n and oxygen and their potential re(...TRUNCATED) | [0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,1,0,0,1,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0(...TRUNCATED) |
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