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https://openalex.org/W2756060471
https://www.nature.com/articles/s41598-017-11969-5.pdf
English
null
Bacteriological diagnosis of childhood TB: a prospective observational study
Scientific reports
2,017
cc-by
7,125
Bacteriological diagnosis of childhood TB: a prospective observational study y Andrew J. Brent   1,2,3,4, Daisy Mugo1, Robert Musyimi1, Agnes Mutiso1, Susan C. Morpeth1 Michael Levin3 & J. Anthony G. Scott   1,2,5 Received: 16 June 2017 Accepted: 1 September 2017 Published: xx xx xxxx Received: 16 June 2017 Accepted:...
https://openalex.org/W4285337868
https://www.thieme-connect.de/products/ejournals/pdf/10.5999/aps.2021.01578.pdf
English
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Archives of plastic surgery
2,021
cc-by
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Kun Hwang Ethics Editor, Archives of Plastic Surgery Department of Plastic Surgery, Inha University College of Medicine, Incheon, Korea “In the morning, my hair was black like silk bundles. In the eve­ ning, it became white like snow ( ).”–Li Bai ( , 701–762 AD, a Chinese poet) case now. The only difference relates to...
https://openalex.org/W4361961528
https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_S1_from_Dual_targeting_of_Raf_and_VEGF_receptor_2_reduces_growth_and_metastasis_of_pancreatic_cancer_through_direct_effects_on_tumor_cells_endothelial_cells_and_pericytes/22483097/1/files/39934631.pdf
English
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Supplementary Fig. S1 from Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes
null
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250.0 300.0 24h 48h D. 150.0 200.0 48h change in O.D * * * 0 0 50.0 100.0 %-c * * 0.0 Control 0.25µM 0.5µM 1µM 2µM 5µM Suppl. Figure 1: Effect of NVP-AAL881 on endothelial cell proliferation. Antiproliferative effects were evaluated by MTT analysis, demonstrating that NVP- AAL881 significantly reduced cell proliferatio...
https://openalex.org/W2003525528
https://europepmc.org/articles/pmc2979596?pdf=render
English
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5-Methyl-3,6,7,8a-tetrahydro-2<i>H</i>-diimidazo[1,2-<i>c</i>:1′,2′-<i>e</i>]pyrido[1,2-<i>a</i>][1,3,5]triazin-5-ium iodide
Acta crystallographica. Section E
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organic compounds Experimental Crystal data C12H16N5 +I Mr = 357.20 Monoclinic, P21=n a = 7.6299 (2) A˚ b = 15.3939 (4) A˚ c = 11.4503 (3) A˚  = 92.204 (2) V = 1343.89 (6) A˚ 3 Z = 4 Mo K radiation  = 2.37 mm1 T = 100 K 0.2  0.2  0.1 mm Data collection Oxford Diffraction Xcalibur-E CCD diffractometer Absorptio...
https://openalex.org/W2586351092
https://sciendo.com/pdf/10.1515/sho-2016-0009
English
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Professional Negligence, Mismanagement and Malpractice. Polish Companies in the Light of Supreme Audit Office Materials in the Years 1976-1980
Studia Historiae Oeconomicae
2,016
cc-by-sa
7,170
Krzysztof L es iako w s ki (The University of Łódź, Łódź) Krzysztof L es iako w s ki (The University of Łódź, Łódź) Krzysztof L es iako w s ki (The University of Łódź, Łódź) PROFESSIONAL NEGLIGENCE, MISMANAGEMENT AND MALPRACTICE. POLISH COMPANIES IN THE LIGHT OF SUPREME AUDIT OFFICE MATERIALS IN THE YEARS 1976-1...
https://openalex.org/W3110626367
https://sajs.co.za/article/download/7688/10642
English
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Accomplishments in wheat rust research in South Africa
South African journal of science
2,020
cc-by
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FUNDING: FUNDING: Biotechnology and Biological Sciences Research Council / Department for International Development (BBSRC-DfID; BB/ F004125/1); Sustainable Crop Production Research for International Development, Biotechnology and Biological Sciences Research Council (BBSRC-SCPRID; BB/J011525/1) The objective o...
W2323523459.txt
https://zenodo.org/records/2030262/files/article.pdf
de
Kolloidchemische Studien über die Keimwirkung
Colloid and polymer science/Colloid & polymer science
1,921
public-domain
3,319
254 war durch die konstatierte Beziehung zwischen der Stiirke der Siiuren und ihren • inbezug auf Wolle der Beweis erbracht, d a fi A dsorptionen fiberhaupt durch chemische Affinitiiten bedingt werden. Dieser ScbluB hat soweit ailgemeii~e Gfiltigkeit, insolange nicht etwa gefunden werden sollte, dab die SOrption von Si...
https://openalex.org/W4299883331
https://zenodo.org/records/5180173/files/source.pdf
English
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to the classification and identification of Weinmannia (Cunoniaceae) in Madagascar and the Comoro Islands
Zenodo (CERN European Organization for Nuclear Research)
2,001
cc-by
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MOTS CLÉS Weinmannia, Cunoniaceae, cladistique, classification, clés taxonomiques, inflorescence, Madagascar, Comores. KEY WORDS Weinmannia, Cunoniaceae, cladistics, classification, taxonomic keys, inflorescence, Madagascar, Comoro Islands. RÉSUMÉ Application d’une analyse cladistique à la classificatio...
https://openalex.org/W4391153151
http://journals.alptkptm.org/index.php/jikm/article/download/44/24
Indonesian
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Peningkatan Literasi Menulis Siswa SMA Prawira Marta Melalui Pendampingan Mata Pelajaran Bahasa Indonesia
Jurnal Ilmiah Kampus Mengajar
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cc-by
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Peningkatan Literasi Menulis Siswa SMA Prawira Marta Melalui Pendampingan Mata… 80 Peningkatan Literasi Menulis Siswa SMA Prawira Marta Melalui Pendampingan Mata Pelajaran Bahasa Indonesia Bunga Lidinta Putri1*, Windi Dian Safitri2, Imfrianti Augtiah3, Romi Iriandi Putra4 1,2Fakultas Keguruan dan Ilmu ...
https://openalex.org/W4361814456
https://figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_A_Fully_Human_Insulin-Like_Growth_Factor-I_Receptor_Antibody_SCH_717454_Robatumumab_Has_Antitumor_Activity_as_a_Single_Agent_and_in_Combination_with_Cytotoxics_in_Pediatric_Tumor_Xenografts/22485270/1/files/39936825.pdf
unk
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Supplementary Figure 3 from A Fully Human Insulin-Like Growth Factor-I Receptor Antibody SCH 717454 (Robatumumab) Has Antitumor Activity as a Single Agent and in Combination with Cytotoxics in Pediatric Tumor Xenografts
null
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S2
https://openalex.org/W4205845434
https://www.cambridge.org/engage/api-gateway/coe/assets/orp/resource/item/61134722abc9e20d306ae1d0/original/robin-criterion-on-divisibility.pdf
English
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Robin Criterion on Divisibility
null
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Mathematics Subject Classification (2010) MSC 11M26 · MSC 11A41 · MSC 11A25 Mathematics Subject Classification (2010) MSC 11M26 · MSC 11A41 · MSC 11A25 Noname manuscript No. (will be inserted by the editor) Noname manuscript No. (will be inserted by the editor) Noname manuscript No. (will be inserted by the editor) F. Ve...
https://openalex.org/W2041839138
https://www.scielo.br/j/rlae/a/CJLqkVFpqjFvGXFSdSk99Xw/?lang=en&format=pdf
English
null
Nursing care time and quality indicators for adult intensive care: correlation analysis
Revista latino-americana de enfermagem
2,012
cc-by
5,310
Corresponding Author: Paulo Carlos Garcia Universidade de São Paulo. Hospital Universitário Av. Professor Lineu Prestes, 2565 Bairro: Butantã CEP: 05508-000, São Paulo, SP, Brasil E-mail: paulogarcia@usp.br 1 Paper extracted from Master’s Thesis “Tempo de assistência de enfermagem em UTI e indicadores de qualidade ass...
https://openalex.org/W3140257988
https://pub.epsilon.slu.se/26230/1/schwochow_d_et_al_211129.pdf
English
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The feather pattern <i>autosomal barring</i> in chicken is strongly associated with segregation at the <i>MC1R</i> locus
Pigment cell & melanoma research
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j INTERNATIONAL FEDERATION OF PIGMENT CELL SOCIETIES · SOCIETY FOR MELANOMA RESEARCH PIGMENT CELL & MELANOMA Research The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus Doreen Schwochow | Susanne Bornelöv | Tingxing Jiang | Jingyi Li | David Gourichon | Bertrand ...
https://openalex.org/W2141715488
https://zenodo.org/record/7715/files/Maryam_Farhadis_Paper_in_JATIT.pdf
English
null
Contribution of Information and Communication Technology (ICT) in Country'S H-Index
arXiv (Cornell University)
2,013
cc-by
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1MARYAM FARHADI1*, HADI SALEHI2,3, MOHAMED AMIN EMBI2, MASOOD FOOLADI1, HADI FARHADI4, AREZOO AGHAEI CHADEGANI1, and NADER ALE EBRAHIM5 *Corresponding author: Maryam Farhadi, Email: farhadim58@gmail.com *Corresponding author: Maryam Farhadi, Email: farhadim58@gmail.com Journal of Theoretical and Applied Information Te...
https://openalex.org/W3208432556
https://www.researchsquare.com/article/rs-1016632/latest.pdf
English
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High Prevalence of Urinary Schistosomiasis in a Desert Population: Results from an Exploratory Study Around the Ounianga Lakes in Chad
Research Square (Research Square)
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High Prevalence of Urinary Schistosomiasis in a Desert Population: Results from an Exploratory Study Around the Ounianga Lakes in Chad High Prevalence of Urinary Schistosomiasis in a Desert Population: Results from an Exploratory Study Around the Ounianga Lakes in Chad Wendelin Moser  Swiss Tropical and Public Health I...
https://openalex.org/W1821556543
https://eprint.ncl.ac.uk/fulltext.aspx?url=220220/C9BF4578-C4DC-4A23-B067-B3B519EC089F.pdf&pub_id=220220
English
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New vessels detected on wide-field imaging compared to two-field and seven-field imaging: implications for diabetic retinopathy screening image analysis
British journal of ophthalmology
2,015
cc-by
3,884
Copyright: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/lice...
https://openalex.org/W3126586119
https://biblio.ugent.be/publication/8701492/file/8701495.pdf
English
null
Endophytic Bacteria From the Roots of the Medicinal Plant Alkanna tinctoria Tausch (Boraginaceae): Exploration of Plant Growth Promoting Properties and Potential Role in the Production of Plant Secondary Metabolites
Frontiers in microbiology
2,021
cc-by
12,360
ORIGINAL RESEARCH published: 03 February 2021 doi: 10.3389/fmicb.2021.633488 Edited by: Aleksa Obradovi ´c, University of Belgrade, Serbia A selection of bacteria was then tested for the ability to induce A/S Specialty section: This article was submitted to Microbe and Virus Interactions with Plants, a section of the j...
https://openalex.org/W3083932219
https://obsesi.or.id/index.php/obsesi/article/download/734/pdf
Indonesian
null
Bermain Vegetable Eating Motivation (Vem) terhadap Perilaku Makan Sayuran pada Anak Prasekolah
Jurnal obsesi
2,020
cc-by-sa
6,178
Volume 5 Issue 1 (2021) Pages 879-890 Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini ISSN: 2549-8959 (Online) 2356-1327 (Print) Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh pemberian bermain vegetable eating motivation (VEM) terhadap perilaku makan sayur pada anak prasekolah di TK Asma Jaya Kecamat...
W4387130878.txt
https://www.researchsquare.com/article/rs-3376770/latest.pdf
en
Knockout of a PLD gene in Schizochytrium limacinum SR21 enhances docosahexaenoic acid accumulation by modulation of the phospholipid profile
Research Square (Research Square)
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Knockout of a PLD gene in Schizochytrium limacinum SR21 enhances docosahexaenoic acid accumulation by modulation of the phospholipid profile Yiting Zhang Xiamen University Xiaowen Cui Xiamen University Shuizhi Lin Xiamen University Tao Lu Xiamen University Hao Li Xiamen University Yinghua Lu Xiamen University Mingfeng ...
https://openalex.org/W4283786673
https://nottingham-repository.worktribe.com/preview/12892630/s42234-022-00099-7.pdf
English
null
Electric Field Responsive Nanotransducers for Glioblastoma
bioRxiv (Cold Spring Harbor Laboratory)
2,022
cc-by
7,708
Abstract Background:  Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treat- ment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTFields rely on alternating current (AC) electric fields (EF) leading to the disruption of d...
https://openalex.org/W4306944148
https://tckh.daihoctantrao.edu.vn/index.php/sjttu/article/download/797/767
Vietnamese
null
ĐIỀU TRA, ĐÁNH GIÁ VAI TRÒ CỦA CỘNG ĐỒNG TRONG VIỆC BẢO TỒN MỘT SỐ LOÀI CÂY THUỐC QUÝ HIẾM TẠI KHU BẢO TỒN LOÀI HẠT TRẦN QUÝ HIẾM NAM ĐỘNG, TỈNH THANH HÓA
Khoa học
2,022
cc-by-sa
3,912
Abstract: This paper introduces the research results about the role of the community in the conservation of some rare medicinal plant species in the Nam Dong Valuable Gymnosperm Conservation Area, Thanh Hoa province. As a result, we recorded 21 species belonging to the Vietnam Red Data Book (2007) as Endangered (fi...
https://openalex.org/W2044068963
https://europepmc.org/articles/pmc4117416?pdf=render
English
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Correlated Inter-Domain Motions in Adenylate Kinase
PLOS computational biology/PLoS computational biology
2,014
cc-by
7,524
Introduction DPQ~- m0cPcQh 8p3rPQ3 X ij SijcoswPQ i coswPQ j ð1Þ ð1Þ Conformational heterogeneity as a consequence of dynamics is an intrinsic feature of proteins linked to biological function.[1] An important aspect for our understanding of protein dynamics is a molecular characterization of the structural states that...
https://openalex.org/W791046914
https://www.econstor.eu/bitstream/10419/122198/1/839989199.pdf
English
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Imported Inputs and Egyptian Exports: Exploring the Links
Economics. Journal articles
2,015
cc-by
11,276
Provided in Cooperation with: Suggested Citation: Parra, María Dolores; Martínez-Zarzoso, Inmaculada (2015) : Imported inputs and Egyptian exports: Exploring the links, Economics: The Open-Access, Open-Assessment E- Journal, ISSN 1864-6042, Kiel Institute for the World Economy (IfW), Kiel, Vol. 9, Iss. 2015-38, pp. 1-3...
https://openalex.org/W3113268512
https://hal.science/hal-02889487/file/dl4dh.pdf
English
null
Data lakes for digital humanities
null
2,020
cc-by
3,143
To cite this version: Jérôme Darmont, Cécile Favre, Sabine Loudcher, Camille Noûs. Data Lakes for Digital Humanities. 2nd International Digital Tools & Uses Congress (DTUC 2020), Oct 2020, Hammamet, Tunisia. pp.38- 41, ￿10.1145/3423603.3424004￿. ￿hal-02889487￿ Distributed under a Creative Commons Attribution 4.0 Intern...
https://openalex.org/W2114278866
https://europepmc.org/articles/pmc4599747?pdf=render
English
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Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature
Diagnostic pathology
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cc-by
6,274
* Correspondence: dertoy@hacettepe.edu.tr 1Department of Pathology, Hacettepe University Hospital, Ankara, Turkey Full list of author information is available at the end of the article Ertoy Baydar et al. Diagnostic Pathology (2015) 10:186 DOI 10.1186/s13000-015-0420-z © 2015 Ertoy Baydar et al. Open Access This arti...
https://openalex.org/W2021777081
https://publications.goettingen-research-online.de/bitstream/2/61421/1/Journal_Chemical_Sciences_Mukherjee.pdf
English
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Phenalenyl-based ligand for transition metal chemistry: Application in Henry reaction
Journal of chemical sciences/Proceedings of the Indian Academy of Sciences. Chemical sciences
2,011
cc-by
3,904
J. Chem. Sci. Vol. 123, No. 2, March 2011, pp. 139–144. c⃝Indian Academy of Sciences. J. Chem. Sci. Vol. 123, No. 2, March 2011, pp. 139–144. c⃝Indian Academy of Sciences. ARUP MUKHERJEEa, TAMAL K SENa, SWADHIN K MANDALa,∗, DANIEL KRATZERTb, DIETMAR STALKEb, ALEXANDER DÖRINGb and CAROLA SCHULZKEc aDepartment of Chemica...
https://openalex.org/W3197399723
https://hal.inrae.fr/hal-03594776/document
English
null
Improved bacterial leaf blight disease resistance in the major elite Vietnamese rice cultivar TBR225 via editing of the OsSWEET14 promoter
PloS one
2,021
cc-by
9,703
PLOS ONE PLOS ONE RESEARCH ARTICLE OPEN ACCESS Citation: Duy PN, Lan DT, Pham Thu H, Thi Thu HP, Nguyen Thanh H, Pham NP, et al. (2021) Improved bacterial leaf blight disease resistance in the major elite Vietnamese rice cultivar TBR225 via editing of the OsSWEET14 promoter. PLoS ONE 16(9): e0255470. https://doi.org/10...
https://openalex.org/W4200039588
https://bmccardiovascdisord.biomedcentral.com/track/pdf/10.1186/s12872-022-02527-7
English
null
Relationship Between Epicardial Fat volume on Cardiac CT and Atherosclerosis Severity in Three-Vessel Coronary Artery Disease: A Single-Center Cross-Sectional Study
Research Square (Research Square)
2,021
cc-by
7,423
Sun et al. BMC Cardiovascular Disorders (2022) 22:76 https://doi.org/10.1186/s12872-022-02527-7 Sun et al. BMC Cardiovascular Disorders (2022) 22:76 https://doi.org/10.1186/s12872-022-02527-7 Open Access Relationship between epicardial fat volume on cardiac CT and atherosclerosis severity in ...
https://openalex.org/W3012964330
https://uu.diva-portal.org/smash/get/diva2:1443715/FULLTEXT01
English
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Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper
Biomedicines
2,020
cc-by
13,038
Received: 29 February 2020; Accepted: 21 March 2020; Published: 26 March 2020 Abstract: Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composi...
https://openalex.org/W2804317271
https://hal.umontpellier.fr/hal-01850345/document
English
null
Naturally occurring variations in the nod-independent model legume Aeschynomene evenia and relatives: a resource for nodulation genetics
BMC plant biology
2,018
cc-by
12,283
To cite this version: Clémence Chaintreuil, Xavier Perrier, Guillaume Martin, Joël Fardoux, Gwilym Lewis, et al.. Natu- rally occurring variations in the nod-independent model legume Aeschynomene evenia and relatives: a resource for nodulation genetics. BMC Plant Biology, 2018, 18 (1), pp.54 (1-15). ￿10.1186/s12870- 01...
https://openalex.org/W2943526845
https://europepmc.org/articles/pmc6502861?pdf=render
English
null
The Effect of Freezing on Non-invasive Prenatal Testing
Scientific reports
2,019
cc-by
4,995
Xiaolei Xie1,2, Fuguang Li1, Weihe Tan1, Weiguo Yin2, Feiyan Chen3 & Xiaoyan Guo1 Xiaolei Xie1,2, Fuguang Li1, Weihe Tan1, Weiguo Yin2, Feiyan Chen3 & Xiaoyan Guo1 Plasma cryopreservation is unavoidable in China, due to technical specifications requiring storage of additional plasma at −80 degrees for three years. How...
https://openalex.org/W2148564836
https://discovery.ucl.ac.uk/1433074/1/journal.pgen.1000534.pdf
English
null
Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions
PLOS genetics
2,009
cc-by
15,598
Abstract Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here we describe a statistical method, Gene Relationships Among Implicated Loci (GRAIL), that t...
https://openalex.org/W1982691950
https://zenodo.org/records/2270450/files/article.pdf
Italian
null
Sugli spazii che ammettono un gruppo continuo di movimenti
Annali di matematica pura ed applicata
1,903
public-domain
17,221
(*) Memorie della Soeiet~ Italiana delle Seienze, 1897: Sugli syazii a trc dbnznsioni, che ammettonQ, ece. Ques~a Memoria sara in seguito indieata con (A). Avverto pure ehe la elassiea Theorie der Trans/ormationsgruppen del LIF~-ENGI,:L sar£ indicata in seguito soltanto col home di Lm. Sugli spazii che un gruppo c...
https://openalex.org/W2801734876
https://www.pure.ed.ac.uk/ws/files/58553714/1_s2.0_S0034425718301421_main.pdf
English
null
Heterogeneous and rapid ice loss over the Patagonian Ice Fields revealed by CryoSat-2 swath radar altimetry
Remote sensing of environment
2,018
cc-by
14,199
General rights C i h f h General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rig...
https://openalex.org/W4214736206
https://head-face-med.biomedcentral.com/track/pdf/10.1186/s13005-022-00311-8
English
null
Frequency of osteoradionecrosis of the lower jaw after radiotherapy of oral cancer patients correlated with dosimetric parameters and other risk factors
Head & face medicine
2,022
cc-by
5,562
RESEARCH Open Access Lang et al. Head & Face Medicine (2022) 18:7 https://doi.org/10.1186/s13005-022-00311-8 Lang et al. Head & Face Medicine (2022) 18:7 https://doi.org/10.1186/s13005-022-00311-8 * Correspondence: kristin.lang@med.uni-heidelberg.de Co espo de ce: st . a g@ ed.u e de be g.de 1De...
https://openalex.org/W2808614043
https://europepmc.org/articles/pmc6020487?pdf=render
English
null
Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers
Mediators of inflammation
2,018
cc-by
4,885
Rochette Emmanuelle ,1,2,3,4 Duché Pascale,3,4 Hourdé Christophe,5 Evrard Bertrand,6,7 Pereira Bruno,8 Echaubard Stéphane,1 and Merlin Etienne1,2,6 1Pédiatrie Générale Multidisciplinaire, Hôpital Estaing, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France 2Université Clermont Auvergne, INSERM, CIC 1405, Unité CRECHE,...
https://openalex.org/W2913654792
https://www.frontiersin.org/articles/10.3389/fpsyg.2019.00035/pdf
English
null
Spanish Version of the Flourishing Scale (FS) on the Parents of Children With Cancer: A Validation Through Rasch Analysis
Frontiers in psychology
2,019
cc-by
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Spanish Version of the Flourishing Scale (FS) on the Parents of Children With Cancer: A Validation Through Rasch Analysis Carmen Pozo Muñoz 1* and Blanca Bretones Nieto 2 1 Department of Psychology, University of Almería, Almería, Spain, 2 Psychosocial Intervention and Health (HUM-792) Research Group, University of Alm...
https://openalex.org/W2766508720
https://europepmc.org/articles/pmc5669490?pdf=render
English
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Archigregarines of the English Channel revisited: New molecular data on Selenidium species including early described and new species and the uncertainties of phylogenetic relationships
PloS one
2,017
cc-by
16,254
RESEARCH ARTICLE Editor: Ross Frederick Waller, University of Cambridge, UNITED KINGDOM Editor: Ross Frederick Waller, University of Cambridge, UNITED KINGDOM Received: May 30, 2017 Accepted: October 19, 2017 Published: November 3, 2017 Copyright: © 2017 Rueckert, Hora´k. This is an open access article distributed unde...
https://openalex.org/W2956080616
https://dergipark.org.tr/tr/download/article-file/751643
Turkish
null
Determination of the Performance of Some Apple Cultivars Matured in Different Periods in the Mediterranean Transitional Zone
Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi/Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi
2,019
cc-by
6,043
Determination of the Performance of Some Apple Cultivars Matured in Different Periods in the Mediterranean Transitional Zone Determination of the Performance of Some Apple Cultivars Matured in Different Periods in the Mediterranean Transitional Zone Abstract: Apple is a temperate climate fruit grown in different ecol...
https://openalex.org/W4360608510
https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010537&type=printable
English
null
In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model
PLOS computational biology/PLoS computational biology
2,023
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PLOS COMPUTATIONAL BIOLOGY PLOS COMPUTATIONAL BIOLOGY RESEARCH ARTICLE In vitro–in silico correlation of three- dimensional turbulent flows in an idealized mouth-throat model Eliram NofID1¤a, Saurabh Bhardwaj1¤b, Pantelis Koullapis2, Ron Bessler1, Stavros Kassinos2, Josue´ SznitmanID1* Eliram NofID1¤a, Saurabh Bhardwaj...
https://openalex.org/W2626932481
https://www.nature.com/articles/oncsis201749.pdf
English
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TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
Oncogenesis
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1PLA General Hospital Cancer Center Key Lab, PLA Postgraduate School of Medicine, Beijing, China; 2Molecular Pathology Laboratory, College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China; 3Department of Orthopedics, PLA General Hospital, Beijing, China; 4International Joint Cancer Institute, The Sec...
https://openalex.org/W4225794751
https://zenodo.org/record/6411219/files/1203-Wei.pdf
English
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Use of English Phrasal Verbs of Chinese Students Across Proficiency Levels: A Corpus-Based Analysis
Zenodo (CERN European Organization for Nuclear Research)
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English phrasal verbs, Chinese learner corpus, proficiency level, single-word synonyms English phrasal verbs, Chinese learner corpus, proficiency level, single-word synonyms Use of English Phrasal Verbs of Chinese Students Across Proficiency Levels: A Corpus-Based Analysis Yuanyuan Wei Renmin University of China, Chin...
https://openalex.org/W2032991613
https://bmcearnosethroatdisord.biomedcentral.com/counter/pdf/10.1186/1472-6815-12-7
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Translation and validation of the vertigo symptom scale into German: A cultural adaption to a wider German-speaking population
BMC ear, nose and throat disorders
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© 2012 Gloor-Juzi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly...
https://openalex.org/W3178207702
https://ajlmonline.org/index.php/ajlm/article/download/1363/1991
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Molecular characterisation of NPM1 and FLT3-ITD mutations in a central South African adult de novo acute myeloid leukaemia cohort
African journal of laboratory medicine
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African Journal of Laboratory Medicine ISSN: (Online) 2225-2010, (Print) 2225-2002 Page 1 of 6 Original Research Page 1 of 6 Original Research Page 1 of 6 Page 1 of 6 Dates: Keywords: acute myeloid leukaemia; AML; NPM1; FLT3-ITD; frequency; South Africa. Keywords: acute myeloid leukaemia; AML; NPM1; FLT3-ITD; frequenc...
https://openalex.org/W3155935105
https://pure.eur.nl/ws/files/55041714/bmjopen_2020_044544.pdf
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Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey
BMJ open
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To cite: Hermelijn S, Kersten C, Mullassery D, et al. Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey. BMJ Open 2021;11:e044544. doi:10.1136/ bmjopen-2020-044544 Protocol Protocol Open access Development of a core outcome set for...
https://openalex.org/W2289740595
https://europepmc.org/articles/pmc4774145?pdf=render
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Phospholipid analysis in sera of horses with allergic dermatitis and in matched healthy controls
Lipids in health and disease
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* Correspondence: raija.hallamaa@elisanet.fi 1Veterinary Clinic, Nummela, Finland 2University of Helsinki, Faculty of Veterinary Medicine, Helsinki, Finland Full list of author information is available at the end of the article © 2016 Hallamaa and Batchu. Open Access This article is distributed under the terms of the C...
https://openalex.org/W4396657622
https://wjbphs.com/sites/default/files/WJBPHS-2024-0235.pdf
English
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Analysis of biological organic extract of plants in suppressing aphid (Myzus persicae) infestations
World Journal of Biology Pharmacy and Health Sciences
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Abstract Myzus persicae commonly known as the peach-potato aphid, poses a significant threat to agricultural productivity, particularly in potato cultivation, where infestations lead to substantial yield losses and quality degradation. In this study, we investigated the potential of botanical extracts from neem (Azad...
https://openalex.org/W2594240068
https://journal.rniito.org/jour/article/download/95/93
Russian
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Results of the proximal humerus endoprosthetic reconstruction after tumour resection
Travmatologiâ i ortopediâ Rossii
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И.М. Микайлов, П.В. Григорьев, Д.А. Пташников, С.В. Майков ФГБУ «Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена» Минздрава России Санкт-Петербург, Россия Цель исследования – оценить результаты эндопротезирования плечевого сустава после радикальной резекции опу- холи проксималь...
https://openalex.org/W2346613878
https://revistas.ufg.br/sig/article/download/35551/19774
Portuguese
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Paradigma indiciário: contribuições para a investigação da construção das identidades de futuros professores de línguas
Signótica
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10.5216/sig.v27i2.35551 10.5216/sig.v27i2.35551 10.5216/sig.v27i2.35551 * Professora Associada do Instituto de Letras da Universidade Federal da Bahia (UFBA). E-mail: liviarad@yahoo.com. Resumo Este trabalho trata das contribuições do paradigma indiciário para o estudo das identidades docentes e, particularmente, as...
https://openalex.org/W4386556418
https://zenodo.org/records/8329611/files/14.pdf
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Psychoanalytic Reading of Decadence and Crisis in Ted Hughes' "Relic" and T.S. Eliot's "The Hollow Men"
Zenodo (CERN European Organization for Nuclear Research)
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INTRODUCTION Literature often serves as a mirror reflecting the complexities of human experience, unraveling the intricate layers of emotion, thought, and societal context. In twentieth century poetry, T.S. Eliot and Ted Hughes emerge as witnesses to the two consecutive turbulent eras. Hughes’ “Relic” and Eliot’s “Th...
https://openalex.org/W3121741768
https://journals.ums.ac.id/index.php/dayasaing/article/download/12507/6336
Indonesian
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DAMPAK WABAH COVID-19 TERHADAP PENJUALAN JAHE MERAH DI SURAKARTA
Jurnal Manajemen Dayasaing/Jurnal manajemen dayasaing
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DAYA SAING Jurnal Ekonomi Manajemen Sumber Daya Vol. 22, No. 2, Desember 2020 DAYA SAING Jurnal Ekonomi Manajemen Sumber Daya Vol. 22, No. 2, Desember 2020 DAMPAK WABAH COVID-19 TERHADAP PENJUALAN JAHE MERAH Hendi Yudhanto Adinugroho1, Liana Mangifera2, Rizcho Louistama Setyana Putra3, Fida Nur Rahma4, Calista Amel...
https://openalex.org/W4391073096
https://ejtas.com/index.php/journal/article/download/574/452
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The Influence of Technology on Accounting Practices in India: A Survey of Accounting Software Utilization by Micro Enterprises in Delhi
European journal of theoretical and applied sciences
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Abstract: significant in urban areas like Delhi, where micro enterprises form a vital component of the local economy. The advent of various accounting software solutions has enabled these businesses to manage their financial transactions more Abstract: Suggested Citation Gupta, R. (2023). The Influence of Technol...
https://openalex.org/W4328094146
https://bcpublication.org/index.php/BM/article/download/3685/3605
English
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ESG Index Construction and China's ESG System
BCP business & management
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ESG Index Construction and China's ESG System Lanyi Duan* Lanyi Duan* School of Economics, University College Dublin, Dublin, Ireland *Corresponding author: lanyi.duan@ucdconnect.com Abstract. The Environmental, Social, and Governance (ESG) system has gained popularity recently as concerns over issues like corporat...
https://openalex.org/W4389257226
https://www.scielo.br/j/cm/a/DNvVPwH4sHbMFBgZpWmNyGC/?lang=en&format=pdf
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“Leisure” spaces within work environments in the “Performance society”
Cadernos Metrópole
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“Leisure” spaces within work environments in the “Performance society” Espaços de “lazer” em ambientes de trabalho na “Sociedade de desempenho” Simone Jubert [I] Lúcia Leitão [II] Cad. Metrop., São Paulo, v. 26, n. 59, pp. 191-208, jan/abr 2024 http://dx.doi.org/10.1590/2236-9996.2024-5909.e Introduction Richard Sennet...
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https://periodicos.pucpr.br/dialogoeducacional/article/download/25454/24111
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A perspectiva dialógica na formação de professores
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http://doi.org/10.7213/1981-416X.20.064.AO08 ISSN 1981-416X A perspectiva dialógica na formação de professores The dialogical perspective in teacher training La perspectiva dialógica en la formación de profesores LUCICLEIDE ARAÚJO DE SOUSA ALVES a LUIZ SÍVERES b Resumo Apresenta caminhos metodológicos na formação...
https://openalex.org/W2006843710
https://ccforum.biomedcentral.com/track/pdf/10.1186/cc8093
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T-cell-specific peroxisome proliferator-activated receptor gamma depletion inhibits T-cell apoptosis and improves survival of septic mice via an IL-2-dependent mechanism
Critical care
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P2 Methods Pneumonia was induced by intranasal instillation of bacteria (104 CFU) while sepsis was developed by placing the fibrin–thrombin clot containing a known amount of bacteria (102 CFU) into the peritoneal cavity of animals. Various cytokine (TNFα and IL-1α) levels were estimated using ELISA and the degree of lu...
https://openalex.org/W3217631785
http://eprints.lse.ac.uk/115191/1/93_1266_1_PB.pdf
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Colombia, the Drug Wars and the Politics of Drug Policy Displacement – from La Violencia to UNGASS 2016
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Collins, J and Alarcón, KT. 2021. Colombia, the Drug Wars and the Politics of Drug Policy Displacement – from La Violencia to UNGASS 2016. Journal of Illicit Economies and Development, 3(2), pp. 190–205. DOI: https://doi.org/10.31389/jied.93 Collins, J and Alarcón, KT. 2021. Colombia, the Drug Wars and the Politics...
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https://europepmc.org/articles/pmc6702493?pdf=render
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Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells
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Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells Huahong Yang 1, Yun Gao 1, Xiaoye Fan 2, Xingkai Liu 3, Liping Peng 1* and Xinxin Ci 2* 1 Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China, 2 Institute of Tran...
W3141647081.txt
https://www.scilook.eu/index.php/slif/article/download/slif13-02-008/pdf13-02-008
uk
АГРОЭКОЛОГИЧЕСКОЕ ОБОСНОВАНИЕ ВНЕСЕНИЯ УДОБРЕНИЙ ПОД ОЗИМУЮ ПШЕНИЦУ СОРТА «МИРОНОВСКАЯ 61»
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WWW.SCILOOK.EU Совместно с: Институт морехозяйства и предпринимательства При научной поддержке: Экономическая академия им.Д.А.Ценова (Болгария) Московский государственный университет путей сообщения (МИИТ) Украи инская госуд дарств вен нна ая ака адем мия я железзнод дорож жного тра ансп портта Нау учно о-иссле едо...
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https://differentvisions.org/wp-content/uploads/sites/1356/2023/04/Issue-5-Salih.pdf
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The Trouble with “Female Sexuality”
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The Trouble with “Female Sexuality” Sarah Salih • King’s College London Recommended citation: Sarah Salih, “The Trouble with ‘Female Sexuality,’” Different Visions: New Perspectives on Medieval Art 5 (2016). https://doi.org/10.61302/IRRS2726. Using medieval western art to speak of female sexuality is difficult. Karma L...
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https://europepmc.org/articles/pmc3927567?pdf=render
English
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Toxicological Study of<i>Ocimum sanctum</i>Linn Leaves: Hematological, Biochemical, and Histopathological Studies
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Hindawi Publishing Corporation Journal of Toxicology Volume 2014, Article ID 135654, 9 pages http://dx.doi.org/10.1155/2014/135654 Hindawi Publishing Corporation Journal of Toxicology Volume 2014, Article ID 135654, 9 pages http://dx.doi.org/10.1155/2014/135654 Hindawi Publishing Corporation Journal of Toxicology Volum...
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https://www.frontiersin.org/articles/10.3389/fpls.2017.01925/pdf
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State of the Art: trxG Factor Regulation of Post-embryonic Plant Development
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Keywords: trxG, PcG, development, chromatin, histone methylation, transcription, epigenetics, Arabidopsis Keywords: trxG, PcG, development, chromatin, histone methylation, transcription, epigenetics, Arabidopsis Reviewed by: Isabel Bäurle, University of Potsdam, Germany Keqiang Wu, National Taiwan University, Taiwan Re...
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http://www.scielo.br/pdf/bdj/v28n6/1806-4760-bdj-28-06-726.pdf
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Influence of Different Concentration and Ratio of a Photoinitiator System on the Properties of Experimental Resin Composites
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ISSN 0103-6440 ISSN 0103-6440 Brazilian Dental Journal (2017) 28(6): 726-730 http://dx.doi.org/10.1590/0103-6440201701372 1Department of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, UNICAMP - Universidade Estadual de Campinas, Piracicaba, SP, Brazil 2Department of Prosthodontics, UNI...
https://openalex.org/W4283264301
https://www.researchsquare.com/article/rs-141892/latest.pdf
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Effects of Psychological Capital, Coping Style and Emotional Intelligence on Self-Rated Health Status of College Students in China During COVID-19 Pandemic
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Associations of psychological capital, coping style and emotional intelligence with self-rated health status of college students in China during COVID-19 pandemic Xiangzhi Jing  Xinyang Vocational and Technical college Hongling Meng  Zhengzhou Normal University Yuping Li  Zhengzhou Normal University Lingeng Lu  Yale Un...
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https://europepmc.org/articles/pmc4440664?pdf=render
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A Unifying Model for Capture–Recapture and Distance Sampling Surveys of Wildlife Populations
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1. INTRODUCTION tion is not certain, effective area sampled is obtained by in- tegrating under an estimated detection probability surface. DS methods estimate the detection probability surface by using ob- served distances to detections to estimate detection probability as a function of distance from detector. CR metho...
https://openalex.org/W2993411573
https://hal.archives-ouvertes.fr/hal-03370736/document
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Short-term availability of adult-born neurons for memory encoding
Nature communications
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To cite this version: Jérémy Forest, Mélissa Moreno, Matthias Cavelius, Laura Chalençon, Anne Ziessel, et al.. Short- term availability of adult-born neurons for memory encoding. Nature Communications, 2019, 10 (1), ￿10.1038/s41467-019-13521-7￿. ￿hal-03370736￿ Distributed under a Creative Commons Attribution 4.0 Intern...
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https://www.qeios.com/read/3TS65E/pdf
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Serine/Threonine Kinase Inhibitor XL418
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Serine/Threonine Kinase Inhibitor XL418 National Cancer Institute National Cancer Institute Qeios ID: 3TS65E · https://doi.org/10.32388/3TS65E Qeios · Definition, February 7, 2020 Open Peer Review on Qeios Source National Cancer Institute. Serine/Threonine Kinase Inhibitor XL418. NCI Thesaurus. Code C68963. A s...
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Topography evolution of germanium thin films synthesized by pulsed laser deposition
AIP advances
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RESEARCH ARTICLE | APRIL 17 2017 Topography evolution of germanium thin films synthesized by pulsed laser deposition RESEARCH ARTICLE | APRIL 17 2017 P. Schumacher; S. G. Mayr; B. Rauschenbach AIP Advances 7, 045115 (2017) https://doi.org/10.1063/1.4981800 Articles You May Be Interested In Initial perturbation matter...
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Agile logistics challenges of petroleum product distribution in Nigeria
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Agile logistics challenges of petroleum product distribution in Nigeria national Journal of Science and Research Archive, 2024, 11(02), 531–542 Publication history: Received on 04 February 2024; revised on 12 March 2024; accepted on 15 March 2024 Article DOI: https://doi.org/10.30574/ijsra.2024.11.2.0436 Abstract Agile...
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biomedicines Review Clinical Activity and Tolerability of SL-401 (Tagraxofusp): Recombinant Diphtheria Toxin and Interleukin-3 in Hematologic Malignancies Omar Alkharabsheh * and Arthur E. Frankel Division of Medical Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA; afrankel@he...
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Inhibition of HIV Virus by Neutralizing Vhh Attached to Dual Functional Liposomes Encapsulating Dapivirine
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© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original au...
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Walks, Partitions, and Normal Ordering
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Abstract We describe the relation between graph decompositions into walks and the nor- mal ordering of differential operators in the n-th Weyl algebra. Under several spec- ifications, we study new types of restricted set partitions, and a generalization of Stirling numbers, which we call the λ-Stirling numbers. Keywords:...
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Shape of Testosterone
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Shape of Testosterone Article Recommendations * Supporting Information * sı * ABSTRACT: We have successfully characterized the structure of testosterone, one of the essential steroids, through high-resolution rotational spectroscopy. A single conformer has been detected, and a total of 404 transitions have been fitted, ...
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ECDSA White-Box Implementations: Attacks and Designs from CHES 2021 Challenge
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Document status and date: Published: 31/08/2022 Document status and date: Published: 31/08/2022 Document Version: Publisher’s PDF, also known as Version of Record (includes final page, issue and volume numbers) Document Version: Publisher’s PDF, also known as Version of Record (includes final page, issue and volume num...
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Qeios, CC-BY 4.0 · Review, July 11, 2023 Review of: "Factors Influencing Access to Credit for Rural People in Ethiopia" Enyang Besong Susan Potential competing interests: No potential competing interests to declare. Thank you for inviting me to review the manuscrip 'Factors Influencing Access to Credit For Rural Peop...
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Progress in the R ecosystem for representing and handling spatial data
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ERROR: type should be string, got "https://doi.org/10.1007/s10109-020-00336-0\nJournal of Geographical Systems (2021) 23:515–546 https://doi.org/10.1007/s10109-020-00336-0\nJournal of Geographical Systems (2021) 23:515–546 ORIGINAL ARTICLE Abstract Twenty years have passed since Bivand and Gebhardt (J Geogr Syst 2(3):307–317, \n2000. https​://doi.org/10.1007/PL000​11460​) indicated that there was a good match \nbetween the then nascent open-source R programming language and environment \nand the needs of researchers analysing spatial data. Recalling the development of \nclasses for spatial data presented in book form in Bivand et al. (Applied spatial data \nanalysis with R. Springer, New York, 2008, Applied spatial data analysis with R, \n2nd edn. Springer, New York, 2013), it is important to present the progress now \noccurring in representation of spatial data, and possible consequences for spatial \ndata handling and the statistical analysis of spatial data. Beyond this, it is imperative \nto discuss the relationships between R-spatial software and the larger open-source \ngeospatial software community on whose work R packages crucially depend. Keywords  Spatial data analysis · Open-source software · R programming language JEL Classification  C00 · C88 · R15 JEL Classification  C00 · C88 · R15 JEL Classification  C00 · C88 · R15 Progress in the R ecosystem for representing and handling \nspatial data Roger S. Bivand1 Received: 9 October 2019 / Accepted: 8 September 2020 \n© The Author(s) 2020\n/ Published online: 16 October 2020 1\t\nDepartment of Economics, Norwegian School of Economics, Helleveien 30, 5045 Bergen, \nNorway *\t Roger S. Bivand \n\t\nroger.bivand@nhh.no *\t Roger S. Bivand \n\t\nroger.bivand@nhh.no\n1\t\nDepartment of Economics, Norwegian School of Economics, Helleveien 30, 5045 Bergen, \nNorway 1  Introduction While Bivand and Gebhardt (2000) did provide an introduction to R as a statistical \nprogramming language and to why one might choose to use a scripted language like \nR (or Python), this article is both retrospective and prospective. It is possible that \nthose approaching the choice of tools for spatial analysis and for handling spatial \ndata will find the following less than inviting; in that case, perusal of early chapters \nof Lovelace et al. (2019) will provide useful context. Two further pointers include \nthe fact that R and most R add-on packages are open-source software and so with-\nout licence fees or other such restrictions. The second pointer is that all scripting 012341 456789)\n3 012341 456789)\n3 516 R. S. Bivand languages provide the structures needed for reproducible research, and open-source \nsoftware gives the interested researcher the means to run the scripts needed to repli-\ncate results without cost, given access to adequate hardware. Hence, an overview of \nthe development of the use of R for handling spatial data can cast light on how and \nwhy steps fashioning today’s software were taken. Of course, an overview of the use \nof R for analysing spatial data would also be tempting, but, with about 900 R pack-\nages using spatial data handling classes and objects, would far exceed the bounds of \na single article. The R statistical programming language and environment has been used for han-\ndling and analysing spatial data since its inception, partly building on its heritage \nfrom S and S-Plus. When the conceptualization of spatial data was introduced in \nthe sp package (Pebesma and Bivand 2005, 2020, on the Comprehensive R Archive \nNetwork (CRAN) since 2005), it was expected that some packages would adopt its \nclasses. Some years later, adoption rates had picked up strongly, as had use of the \nsp-based packages rgdal (Bivand et al. 2020, on CRAN since 2003) for input/output \nand rgeos (Bivand and Rundel 2020, on CRAN since 2011) for geometric manipula-\ntion of vector data. Packages depending on sp classes continue to require support as more mod-\nern data representations have been introduced in the sf (Pebesma 2018, 2020a, on \nCRAN since 2016) and stars (Pebesma 2020c, on CRAN since 2018) packages. 1 3 1  Introduction The sf package provides the data reading and writing, and geometry manipulation \nfunctionalities found in rgdal and rgeos, and an alternative class representation \nfor vector data based on the Simple Features standard (Herring 2011; ISO 2004). The stars package adds facilities for handling spatial and spatio-temporal raster and \nvector data, building in part on work with the spacetime package (Pebesma 2012, \n2020b, on CRAN since 2010) and on raster handling in the raster package (Hij-\nmans 2020a, on CRAN since 2010). The raster package will not be discussed in this \nreview, mostly because information in the Github “rspatial” organization (https​://\ngithu​b.com/rspat​ial) repositories suggests that development is in flux and that raster \nis becoming a new package called terra (Hijmans 2020b). Discussion here will con-\ncentrate on packages developed and maintained by the Github “r-spatial” organiza-\ntion (https​://githu​b.com/r-spati​al) of which I am a member. Newer visualization packages, such as tmap (Tennekes 2018, 2020, on CRAN \nsince 2014), mapview (Appelhans et al. 2020, on CRAN since 2015) and cartog-\nraphy (Giraud and Lambert 2016, 2017, 2020, on CRAN since 2015), give broader \nscope for data exploration and communication. Modelling and analysis packages \ndemonstrate the considerable range of implementations now available and are often \nsupported with additional code provided as supplementary material to journal arti-\ncles, for example in the Journal of Statistical Software spatial statistics special issue \n(Pebesma et al. 2015). The availability of software and scripts provides a helpful \nmechanism supporting reproducible research and hands-on reviewing in which \nreaders can read the code and scripts used in calculating the results presented in \npublished work (see, for example, Sawicka et al. 2018; Lovelace and Ellison 2018; \nEvangelista and Beskow 2018, in one issue of the R Journal). Some packages are used by others in turn forming dependency trees; because of \nthese dependencies, we can speak of an ecosystem. Class representations of data 1 3 Progress in the R ecosystem for representing and handling spatial… 517 are central, with the data frame conceptualization shaping much of the whole R \necosystem. For the modelling infrastructure to perform correctly, the relationships \nbetween objects containing data and the formula representations of models are cru-\ncial. Because both sp and sf provide similar interfaces for the data= arguments for \nmodel fitting functions by behaving as data.frame objects, transition from sp \nto sf representations is convenient by design. 1  Introduction The spdep package (Bivand 2020b, \non CRAN since 2002) for exploratory spatial data analysis and the new spatialreg \npackage (Bivand and Piras 2019, on CRAN since 2019) for spatial regression (split \nout of spdep) have been adapted to accommodate geometries held in sf classes, so \nboth approaches are viable. Other packages, such as mapview, tmap or stplanr \n(Lovelace et al. 2020) have been revised to permit use with both sp and sf objects. In \norder to retain backward compatibility, other central packages may choose to handle \nthe coexistence of sp and sf classes in the same way. Developers of new packages should choose to use sf and stars rather than sp, \nrgdal and rgeos (and terra rather than raster), but existing packages are free to \nadapt, or indeed to stay with sp, rgdal and rgeos, hoping that they may continue to \nbe maintained. Naturally, contributions to maintenance and development from those \nusing software on which one’s work depends are among the “prices” to be “paid” for \nopen-source software, so “hope” may involve commitment to take responsibility for \nmaintenance. If a maintainer is unable to continue in service, software like R add-on \npackages is termed “orphaned”, but may be adopted. This occurred very recently \nwith an R linear programming package lpSolve, which has been adopted by Gábor \nCsárdi to widespread relief and gratitude. Because there is no corporation tasked \nwith maintaining most R add-on packages, their future use has to depend on the user \ncommunity. One key reason why sf is much easier to maintain is that it was written using the \nRcpp package (Eddelbuettel et al. 2011, 2020; Eddelbuettel 2013; Eddelbuettel and \nBalamuta 2018, on CRAN since 2008) to interface C++ code in GDAL and now \nPROJ (both C++11), and GEOS code through the C API, whereas rgdal and rgeos \nhave more fragile handcrafted interfaces originally written for C99 and C++98. Maintaining Rcpp/C++11 interfaces is very much easier than older adaptations not \nas well understood by younger developers. However, the choice of C++ interfaces is \nnot necessarily robust (Kalibera 2019). Since there is a viable alternative to rgdal and rgeos, a fallback in the future for \nsp-dependent packages will be to use sf for reading and writing data, and geometry \nmanipulation, and to coerce to sp classes before passing to existing modelling code \nif sp classes are needed. 1  Introduction Maintainers of actively developed packages using sp vec-\ntor classes intensively and that are also impacted by changes in coordinate reference \nsystems (Sect. 4) are advised to consider transitioning to sf, as substantial revisions \nwill be needed anyway. In this review and prospect, the progress seen over the last 20  years will be \ndescribed, together with the unexpected consequences it engendered. The emer-\ngence of new technologies and standards has also led to the desirability of re-imple-\nmentation of data representations and analysis functionality, some of which is now \nin place and which will be described. Changes also impact the open-source librar-\nies on which core spatial functionality is built, leading to challenges in ensuring 1 3 3 3 518 R. S. Bivand backward compatibility. This will be shown using the example of coordinate refer-\nence systems. In terms of positionality, much of what follows will be presented from \nthe point of view of the author, documented as far as possible from email exchanges \nand similar sources. It is more than likely that other participants in the development \nof the R-spatial community may recall things differently, and of course, I acknowl-\nedge that this description is bound to be partial. 1  Typically plastic boxes containing static software licences attached to a computer port, often the paral-\nlel port otherwise used for printers in the pre-USB era. 2  \u0007Spatial data classes in the sp package CRAN listings show tripack (Renka and Geb-\nhardt 2020) and akima (Akima and Gebhardt 2020)—both with non-open-source 1 3 Progress in the R ecosystem for representing and handling spatial… 519 licences—available from August 1998 ported by Albrecht Gebhardt; ash and sgeo-\nstat (Majure and Gebhardt 2016) followed in April 1999. The spatial package was \navailable as part of MASS (the software supporting the four editions of Venables \nand Ripley 2002), also ported in part by Albrecht Gebhardt. In the earliest period, \nCRAN administrators helped practically with porting and publication. Albrecht and \nI presented an overview of possibilities of using R for research and teaching in spa-\ntial analysis and statistics in August 1998, subsequently published in this journal as \nBivand and Gebhardt (2000). Rowlingson and Diggle (1993) describe the S-PLUS version of splancs (Rowl-\ningson and Diggle 2017) for point pattern analysis. I had contacted Barry Rowl-\ningson in 1997, but only moved forward with porting as R’s package mechanism \nmatured. In September 1998, I wrote to him: “It wasn’t at all difficult to get things \nrunning, which I think is a result of your coding, thank you!” However, I added this \nspeculation: “An issue I have thought about a little is whether at some stage Albrecht \nand I wouldn’t integrate or harmonize the points and pairs objects in splancs, spa-\ntial and sgeostat—they aren’t the same, but for users maybe they ought to appear to \nbe so”. This concern with class representations for geographical data turned out to \nbe fruitful. A further step was to link GRASS and R, described in Bivand (2000), and fol-\nlowed up at several meetings and working closely with Markus Neteler. The inter-\nface has evolved, and its current status is presented by Lovelace et al. (2019, chap-\nter 9). A consequence of this work was that the CRAN team suggested that I attend a \nmeeting in Vienna in early 2001 to talk about the GRASS GIS interface. The meet-\ning gave unique insights into the dynamics of R development, and very valuable \ncontacts. Later the same year Luc Anselin and Serge Rey asked me to take part in a \nworkshop in Santa Barbara, which again led to many fruitful new contacts; my talk \neventually appeared as Bivand (2006), but the contacts made at the workshop were \nvery useful. 2  \u0007Spatial data classes in the sp package In the early and mid-1990s, those of us who were teaching courses in spatial analysis \nbeyond the direct application of geographical information systems (GIS) found the \npaucity of software limiting. In institutions with funding for site licences for GIS, it \nwas possible to write or share scripts for Arc/Info (in AML), ArcView (in Avenue) \nor later in Visual Basic for ArcGIS. If site licences and associated dongles1 used \nin the field were a problem (including problems for students involved in fieldwork \nin research projects), there were few alternatives, but opportunities were discussed \non mailing lists. One of these was the AI-Geostats listserve/mailing list started by \nGregoire Dubois in 1995; AI meant Arc/Info. Another community gathered around \nGRASS GIS and its transition to open-source development; it hosted, among other \nthings, src.contrib and src.garden directory trees with analysis tools (see \ncode stored in the https​://githu​b.com/OSGeo​/grass​-legac​y repository). From late 1996, the R programming language and environment began to be seen \nas an alternative for teaching and research involving spatial analysis by a few people \nincluding the author and Albrecht Gebhardt. R uses much of the syntax of S, then \navailable commercially as S-Plus, but was and remains free to install, use and extend \nunder the GNU General Public License (GPL). In addition, it could be installed \nportably across multiple operating systems, including Windows and Apple Mac OS. At about the same time, the S-Plus SpatialStats module was published (Kaluzny \net al. 1998), and a meeting occurred in Leicester in which many of those looking \nfor solutions took part. (My contribution was published in the meeting special issue \nBivand 1998.) Much of the porting of S code to R for spatial statistics was begun by Albrecht \nGebhardt as soon as the R package mechanism matured. The library() func-\ntion was upgraded in R 0.60 published in December 1997, and the Comprehensive \nR Archive Network was operating in January 1998. An exchange between Albre-\ncht Gebhardt and Thomas Lumley on the R-beta mailing list (https​://stat.ethz.ch/\npiper​mail/r-help/1997-Novem​ber/00188​2.html) shows that the package mecha-\nnism was not yet working predictably before 0.60 for contributed packages. Since \nteachers moving courses from S to R needed access to the S libraries previously \nused, porting was a crucial step. 2  \u0007Spatial data classes in the sp package Further progress during the intervening 4 years in the use of R in spa-\ntial econometrics was reported in Bivand (2002), building on Bivand and Gebhardt \n(2000), but preceding the release of the spdep package. During the second half of 2002, it seemed relevant to propose a spatial statis-\ntics paper session at the next Vienna meeting to be held in March 2003 (known as \nDistributed Statistical Computing (DSC) and led to useR! meetings), together with \na workshop to discuss classes for spatial data. I had reached out to Edzer Pebesma \nas an author of the stand-alone open-source program gstat (Pebesma and Wes-\nseling 1998); it turned out that he had just been approached to wrap the program for \nS-Plus. He saw the potential of the workshop immediately, and in November 2002 \nwrote in an email: “I wonder whether I should start writing S classes. I’m afraid \nI should”. Virgilio Gómez-Rubio had been developing two spatial packages, RAr-\ncInfo (Gómez-Rubio and López-Quílez 2005; Gómez-Rubio 2011) and DCluster \n(Gómez-Rubio et al. 2005, 2015), and was committed to participating. Although he \ncould not get to the workshop, Nicholas Lewin-Koh wrote in March 2003 that: “I \nwas looking over all the DSC material, especially the spatial stuff. I did notice, after \nlooking through peoples’ packages that there is a lot of duplication of effort. My \nsuggestion is that we set up a repository for spatial packages similar to the Biocon-\nductor mode, where we have a base spatial package that has S-4-based methods and 1 3 3 520 R. S. Bivand classes that are efficient and general.” Straight after the workshop, a collaborative \nrepository for the development of software using SourceForge was established, and \nthe R-sig-geo mailing list (still with over 3600 subscribers) was created to facilitate \ninteraction. classes that are efficient and general.” Straight after the workshop, a collaborative \nrepository for the development of software using SourceForge was established, and \nthe R-sig-geo mailing list (still with over 3600 subscribers) was created to facilitate \ninteraction. So the mandate for the development of the sp package emerged in discussions \nbetween interested contributors before, during and especially following the 2003 \nVienna workshop; most of us met at Pörtschach am Wörthersee in October 2003 \nat a meeting organized by Albrecht Gebhardt. 2  \u0007Spatial data classes in the sp package Coding meetings were organized by \nBarry Rowlingson in Lancaster in November 2004 and by Virgilio Gómez-Rubio \nin Valencia in May 2005, at both of which the class definitions and implementa-\ntions were stress-tested and often changed radically; the package was first published \non CRAN in April 2005. The underlying model adopted was for S4 (new style) \nclasses to be used, for \"Spatial\" objects, whether raster or vector, to behave like \n\"data.frame\" objects, and for visualization methods to make it easy to show the \nobjects. Package developers could choose whether they would use sp classes and \nmethods directly, or rather use those classes for functionality that they did not pro-\nvide themselves. The spatstat package (Baddeley and Turner 2005; Baddeley et al. 2015, 2020) was an early example of such object conversion (known as coercion in \nS and R) to and from sp classes and classes, with the coercion methods published in \nthe maptools package (Bivand and Lewin-Koh 2020).i Reading and writing ESRI Shapefiles had been possible using the maptools \npackage (Bivand and Lewin-Koh 2020) available from CRAN since August 2003, \nbut rgdal, on CRAN from November 2003, interfacing the external GDAL library \n(Warmerdam 2008) and first written by Tim Keitt, initially only supported accessing \nand reading raster data. Further code contributions by Barry Rowlingson for han-\ndling projections using the external PROJ.4 library and the vector drivers in the then \nOGR part of GDAL were folded into rgdal, permitting reading vector and raster \ndata into sp-objects and writing from sp-objects. For vector data, it became possible \nto project coordinates, and in addition to transform them where datum specifications \nwere available. Until 2019, the interfaces to GDAL and PROJ had been relatively \nstable, and upstream changes had not led to breaking changes for users of pack-\nages using sp classes or rgdal functionalities, although they have involved signifi-\ncant maintenance effort. The final part of the framework for spatial vector data han-\ndling was the addition of the rgeos package interfacing the external GEOS library \nin 2011, thanks to Colin Rundell’s 2010 Google Summer of Coding project. The \nrgeos package provided vector topological predicates and operations typically found \nin GIS such as intersection; note that by this time, both GDAL and GEOS used the \nSimple Features vector representation internally. By the publication of Bivand et al. 1 3 readxl\nwithr\nleaflet\ntidyr\nglue\nhtmlwidgets\nrjson\nstringi\nshiny\nrlang\ncrayon\nrvest\ncovr\nDT\ntibble\ndplyr\ntidyverse\nbroom\ntidyselect\nmaps\nhttr\nxml2\nassertthat\nhtmltools\nknitr\nrmarkdown\ndigest\nR6\nspelling\npurrr\nmagrittr\ncurl\nlubridate\nRCurl\nreadr\nsf\ntestthat\ndata.table\nXML\ndevtools\nrstudioapi\nkableExtra\nforeign\ntinytest\nroxygen2\nstringr\nyaml\njsonlite\nvdiffr\nshinyjs readxl\nwithr\nleaflet\ntidyr\nglue\nhtmlwidgets\nrjson\nstringi\nshiny\nrlang\ncrayon\nrvest\ncovr\nDT\ntibble\ndplyr\ntidyverse\nbroom\ntidyselect\nmaps\nhttr\nxml2\nassertthat\nhtmltools\nknitr\nrmarkdown\ndigest\nR6\nspelling\npurrr\nmagrittr\ncurl\nlubridate\nRCurl\nreadr\nsf\ntestthat\ndata.table\nXML\ndevtools\nrstudioapi\nkableExtra\nforeign\ntinytest\nroxygen2\nstringr\nyaml\njsonlite\nvdiffr\nshinyjs geosphere\npedometrics\ndeldir\nstabs\nakima\nspacetime\nmaptools\nspData\nFRK\nspam\nRStoolbox\nbiomod2graph4lg\nRandomFields\nspatialreg\ndismo\nINLA\nspatstat\nSSDM\nsp\ngeoR\nENMTools\nCARBayes\nGSIF\ngstat\nmuHVT\nBiodiversityR\nrnaturalearth\necospat\nfields\nspdep\nagricolae\nrgeos\nsplancs\nadehabitatLT\nrdwd\nrasterVis\ntree\nrgdal\ntrajectories\nspatialEco\ninlabru\nraster\nrworldmap\ngdistance\nmapdata\nRgoogleMaps\nCSTools\nplotKML\nsnowfall Fig. 1   Wordclouds of CRAN and BioConductor package dependencies, August 2020, left panel: cluster \n6 (pagerank range 0.002196–0.000070), right panel: cluster 2 (pagerank range 0.022419–0.000390, sf = \n0.000972) Fig. 1   Wordclouds of CRAN and BioConductor package dependencies, August 2020, left panel: cluster \n6 (pagerank range 0.002196–0.000070), right panel: cluster 2 (pagerank range 0.022419–0.000390, sf = \n0.000972) among the cumulated packages held on CRAN and those published by the Biocon-\nductor project. The left panel shows cluster 6, the spatial cluster with sp having a \npagerank of 0.002196, while the right panel shows cluster 2, which is dominated by \npackages developed by RStudio, a commercial company. The sf package is in cluster \n2, with a pagerank score of 0.000972, most likely in that cluster because it itself uses \nmany of the functionalities of RStudio packages. The two word clouds are scaled by \nthe largest pagerank of included packages, so the scales differ by almost an order of \nmagnitude. 2  https​://githu​b.com/rwinl​ib/gdal2​, https​://githu​b.com/rwinl​ib/gdal3​. 2  \u0007Spatial data classes in the sp package (2008), a few packages not written or main-\ntained by the book authors and their nearest collaborators had begun to use sp \nclasses. By the publication of the second edition (Bivand et al. 2013), we had seen \nthat the number of packages depending on sp, importing from and suggesting it (in \nCRAN terminology for levels of dependency) had grown strongly. In late 2014, de \nVries (2014) looked at CRAN package clusters from a page rank graph and found a \nclear spatial cluster that we had not expected. Figure 1 shows word clouds with char-\nacter sizes proportional to pagerank scores for two clusters found in August 2020 1 3 Progress in the R ecosystem for representing and handling spatial… 521 3  \u0007Spatial data classes in the sf and stars packages The raster package complemented sp for handling raster objects and their inter-\nactions with vector objects. It added to input/output using GDAL through rgdal, \nand better access to NetCDF files. It may be mentioned in passing that thanks to \nhelp from CRAN administrators and especially Brian Ripley, CRAN binary builds \nof rgdal for Windows and Apple Mac OSX became available from 2006, but with \na limited set of vector and raster drivers. Support from CRAN adminstrators and \nthe maintainers of the Github rwinlib/gdal2 and rwinlib/gdal3 repositories2 remains \ncentral to making packages available to users who are not able to install R source \npackages themselves, particularly linking to external libraries. Initially, raster was \nwritten in R using functionalities in sp and rgdal with rgeos coming later. It used a \nfeature of GDAL raster drivers permitting the successive reading of subsets of ras-\nters by row and column, allowing the processing of much larger objects than could \nbe held in memory. In addition, the concepts of bricks and stacks of rasters were \nintroduced, diverging somewhat from the sp treatment of raster bands as stacked \ncolumn vectors in a data frame. 1 3 522 R. S. Bivand As raster evolved, two other packages emerged raising issues with the ways in \nwhich spatial objects had been conceptualized in sp. The rgeos package used the C \napplication programming interface (API) to the C++ GEOS library, which is itself a \ntranslation of the Java Topology Suite (JTS). While the GDAL vector drivers did use \nthe standard Simple Features representation of vector geometries, it was not strongly \nenforced. This laxity now seems most closely associated with the use of ESRI Shape \nfiles as a de facto file standard for representation, in which some Simple Features \nare not consistently representable.3 Both JTS and GEOS required a Simple Features \ncompliant representation and led to the need for curious and fragile adaptations. For \nexample, these affected the representation of sp \"Polygons\" objects, which were \noriginally conceptualized after the Shapefile specification: ring direction determined \nwhether a ring was exterior or interior (a hole), but no guidance was given to show \nwhich exterior ring holes might belong to. As R provides a way to add a character \nstring comment to any object, such comments were added to each \"Polygons\" \nobject encoding the necessary information. 3  \u0007Spatial data classes in the sf and stars packages In this way, GEOS functionality could \nbe used, but the fragility of vector representation in sp was made obvious.f Another package affecting thinking about representation was spacetime, stacking \ncolumns for regular spatio-temporal objects with space varying faster than time. So \na single earth observation band observed repeatedly would be stored in a single col-\numn in a data frame, rather than in the arguably more robust form of a four-dimen-\nsional array, with the band taking one position on the final dimension. The second \nedition of Bivand et al. (2013) took up all of these issues in one way or another, but \nafter completing a spatial statistics special issue of the Journal of Statistical Soft-\nware (Pebesma et al. 2015), it was time to begin fresh implementations of classes for \nspatial data. 3  For recent examples see https​://githu​b.com/OSGeo​/gdal/issue​s/1787 and https​://githu​b.com/r-spati​al/\nsf/issue​s/1121. Progress in the R ecosystem for representing and handling spatial… 523 > df <- data.frame(a=letters[1:3], b=1:3)\n> df$c <- list(d=1, e=\"1\", f=TRUE)\n> str(df)\n’data.frame’: 3 obs. of\n3 variables:\n$ a: chr\n\"a\" \"b\" \"c\"\n$ b: int\n1 2 3\n$ c:List of 3\n..$ d: num 1\n..$ e: chr \"1\"\n..$ f: logi TRUE > df <- data.frame(a=letters[1:3], b=1:3)\n> df$c <- list(d=1, e=\"1\", f=TRUE)\n> str(df)\n’data.frame’: 3 obs. of\n3 variables:\n$ a: chr\n\"a\" \"b\" \"c\"\n$ b: int\n1 2 3\n$ c:List of 3\n..$ d: num 1\n..$ e: chr \"1\"\n..$ f: logi TRUE ’data.frame’: 3 obs. of\n3 variables: $ a: chr\n\"a\" \"b\" \"c\" $ b: int\n1 2 3 $ c:List of 3 ..$ d: num 1 ..$ e: chr \"1\" ..$ f: logi TRUE ..$ f: logi TRUE At useR! in 2016, list columns were declared “tidy”, using examples including \nthe difficulty of encoding polygon interior rings in non-list columns. The decision \nto accommodate “tidy” workflows as well as base-R workflows had already been \nmade, as at least some users only know how to use “tidy” workflows. Pebesma \n(2018) showed the status of the sf towards the end of 2017, with a geometry list \ncolumn containing R wrappers around objects adhering to Simple Features speci-\nfication definitions. Note also that from R 4.0.0, data.frame() does not con-\nvert character columns to factor as it did previously (Hornik 2020); column \n\"a\" is character in R 4 or later, and factor before R 4. 3.1  \u0007Simple Features in R It was clear that vector representations needed urgent attention, so the sf package \nwas begun, aiming to implement the most frequently used parts of the specification \n(ISO 2004; Kralidis 2008; Herring 2011). Development was supported by a grant \nfrom the then newly started R Consortium, which brings together R developers and \nindustry members. A key breakthrough came at the useR! 2016 conference, follow-\ning an earlier decision to re-base vector objects on data frames, rather than as in sp \nto embed a data frame inside a spatial object. Although data frame objects in S and \nR have always been able to take list columns as valid columns, such list columns \nwere not seen as “tidy” (Wickham 2014): 3 Progress in the R ecosystem for representing and handling spatial… > library(sf) The feature geometries are stored in numeric vectors, matrices or lists of \nmatrices and may also be subject to arithmetic operations. Features are held in \nthe \"XY\" class if two-dimensional, or \"XYZ\", \"XYM\" or \"XYZM\" if such coor-\ndinates are available (\"Z\" is usually treated as height and \"M\" as some meas-\nure, perhaps accuracy; both need to have specified units); all single features are \n\"sfg\" (Simple Features geometry) objects, with arithmetic and other operators: > pt1 <- st_point(c(1,3))\n> pt2 <- pt1 + 1\n> pt3 <- pt2 + 1\n> str(pt3)\n’XY’ num [1:2] 3 5 > pt1 <- st_point(c(1,3))\n> pt2 <- pt1 + 1\n> pt3 <- pt2 + 1\n> str(pt3)\n’XY’ num [1:2] 3 5 Geometries may be represented as “Well-Known Text” (WKT): > st_as_text(pt3)\n[1] \"POINT (3 5)\" > st_as_text(pt3)\n[1] \"POINT (3 5)\" > st_as_text(pt3)\n[1] \"POINT (3 5)\" > st_as_text(pt3)\n[1] \"POINT (3 5)\" or as “Well-Known Binary” (WKB) as in database “binary large objects” \n(BLOBs), resolving the problem of representation when working with GDAL vector \ndrivers and functions, and with GEOS predicates and topological operations: 1 3 3 524 R. S. Bivand _\n_\ny(p\n)\n[1] 01 01 00 00 00 00 00 00 00 00 00 08 40 00 00 00 00 00 00 14 40 A column of Simple Features geometries (\"sfc\") is constructed as a list of \"sfg\" \nobjects, which do not have to belong to the same Simple Features category; here, we \nassign the Web Mercator CRS to indicate that the points are projected to the plane, with \nposition measured in metres: > pt_sfc <- st_as_sfc(list(pt1, pt2, pt3), crs=3857)\n> str(pt_sfc)\nsfc_POINT of length 3; first list element:\n’XY’ num [1:2] 1 3 When sf was written, the units package was available (Pebesma et al. > library(sf) 2016, 2020) \nand could utilize the metric of the coordinates given in the declared CRS, so here inter-\npoint distances are measured in metres: > st_distance(pt_sfc)\nUnits: [m]\n[,1]\n[,2]\n[,3]\n[1,] 0.000000 1.414214 2.828427\n[2,] 1.414214 0.000000 1.414214\n[3,] 2.828427 1.414214 0.000000 [3,] 2.828427 1.414214 0.000000 If we re-specify the points as geographical coordinates in decimal degrees on the \nWGS84 ellipsoid, the distances will be given as metres, but measured over the ellipsoid: > pt_sfc1 <- st_as_sfc(list(pt1, pt2, pt3), crs=4326)\n> st_distance(pt_sfc1)\nUnits: [m]\n[,1]\n[,2]\n[,3]\n[1,]\n0.0 156759.1 313424.7\n[2,] 156759.1\n0.0 156665.6\n[3,] 313424.7 156665.6\n0.0 The most recent R Consortium grant covers the extension of analysis and data handling \nto global data representation; Pebesma and Dunnington (2020) present a roadmap for the \nuse of the s2 library for operations on geographical coordinates and its integration in sf. > mat <- matrix(0, 3, 3)\n> mat[1,2] <- mat[2,1] <- s2::s2_distance(st_as_text(pt1), st_as_text(pt2))\n> mat[1,3] <- mat[3,1] <- s2::s2_distance(st_as_text(pt1), st_as_text(pt3))\n> mat[2,3] <- mat[3,2] <- s2::s2_distance(st_as_text(pt2), st_as_text(pt3))\n> mat\n[,1]\n[,2]\n[,3]\n[1,]\n0.0 157106.0 314116.3\n[2,] 157106.0\n0.0 157010.4\n[3,] 314116.3 157010.4\n0.0 1 3 1 3 Progress in the R ecosystem for representing and handling spatial… 525 Finally, an \"sfc\" object, a geometry column, can be added to a data.frame \nobject using st_geometry(), which sets a number of attributes on the object and \ndefines it as also being an \"sf\" object (the \"agr\" attribute if populated shows \nhow observations on non-geometry columns should be understood): > st_geometry(df) <- pt_sfc\n> str(df)\nClasses ‘sf’ and ’data.frame’: 3 obs. of\n4 variables:\n$ a\n: chr\n\"a\" \"b\" \"c\"\n$ b\n: int\n1 2 3\n$ c\n:List of 3\n..$ d: num 1\n..$ e: chr \"1\"\n..$ f: logi TRUE\n$ geometry:sfc_POINT of length 3; first list element:\n’XY’ num\n1 3\n- attr(*, \"sf_column\")= chr \"geometry\"\n- attr(*, \"agr\")= Factor w/ 3 levels \"constant\",\"aggregate\",..: NA NA NA\n..- attr(*, \"names\")= chr [1:3] \"a\" \"b\" \"c\" Classes ‘sf’ and ’data.frame’: 3 obs. 4  util=\"ogr2ogr\", options=\"-nlt CONVERT_TO_LINEAR\".\n5  https​://www.ogc.org/stand​ards/geopa​ckage​. > library(sf) of\n4 variables: $ a\n: chr\n\"a\" \"b\" \"c\" :List of 3 c\n:List of 3 ..$ d: num 1 ..$ e: chr \"1\" ..$ f: logi TRUE - attr(*, \"agr\")= Factor w/ 3 levels \"constant\",\"aggregate\",..: NA NA NA\n..- attr(*, \"names\")= chr [1:3] \"a\" \"b\" \"c\" The sf package implements all of the Simple Features geometry categories, but \nsome geometries need be converted to be used inside R, with, for example, the gdal_\nutils() function to convert curve geometries in an input file to linear geometries.4 \nMany of the functions in the sf package begin with st_ as a reference to the same \nusage in PostGIS, where the letters were intended to symbolize “spatial type”.i The vector file creation and reading functionality found in rgdal is also avail-\nable in sf, with substantial improvements with regard to creating spatial database \ntables and reading from databases. Writing a GeoPackage5 is as easy or easier than \nin rgdal, as the layer= and driver= arguments can be inferred from the given \nfile name. List columns cannot be written, because R list columns are not bound to \nbe consistently of the same type. > tf <- tempfile(fileext=\".gpkg\")\n> st_write(df, dsn=tf, quiet=TRUE)\nWarning message:\nIn clean_columns(as.data.frame(obj), factorsAsCharacter) :\nDropping column(s) c of class(es) list > tf <- tempfile(fileext=\".gpkg\")\n> st_write(df, dsn=tf, quiet=TRUE)\nWarning message:\nIn clean_columns(as.data.frame(obj), factorsAsCharacter) :\nDropping column(s) c of class(es) list > tf <- tempfile(fileext=\".gpkg\")\n> st_write(df, dsn=tf, quiet=TRUE)\nWarning message:\nIn clean_columns(as.data.frame(obj), factorsAsCharacter) :\nDropping column(s) c of class(es) list The standard reading method is st_read, providing a similar functionality to \nthat in rgdal, with a number of differences related to character string encoding that \nwill cease to matter when users migrate to modern formats such as GeoPackage. 3 R. S. > library(sf) Bivand 526 > df1 <- st_read(dsn=tf, quiet=TRUE)\n> df1\nSimple feature collection with 3 features and 2 fields\ngeometry type:\nPOINT\ndimension:\nXY\nbbox:\nxmin: 1 ymin: 3 xmax: 3 ymax: 5\nprojected CRS:\nWGS 84 / Pseudo-Mercator\na b\ngeom\n1 a 1 POINT (1 3)\n2 b 2 POINT (2 4)\n3 c 3 POINT (3 5) In a “tidy” workflow, read_sf() can be used, returning a \"tibble-sf\" \ninheriting from a \"tbl_df\" object rather than from a data frame, and not con-\nverting character string columns into \"factor\" categorical variables by default \n(before R 4.0.0): > read_sf(dsn=tf) %>% dplyr::filter(a == \"c\")\nSimple feature collection with 1 feature and 2 fields\ngeometry type:\nPOINT\ndimension:\nXY\nbbox:\nxmin: 3 ymin: 5 xmax: 3 ymax: 5\nprojected CRS:\nWGS 84 / Pseudo-Mercator\n# A tibble: 1 x 3\na\nb\ngeom\n* <chr> <int> <POINT [m]>\n1 c\n3\n(3 5) sf also integrates GEOS topological predicates and operations into the same \nframework, replacing the rgeos package for access to GEOS functionality. The pre-\ncision and scale defaults differ between sf and rgeos slightly; both remain fragile \nwith respect to invalid geometries, of which there are many in circulation. From \nGEOS 3.8, both rgeos and sf offer functions to create valid geometries from invalid \nones; prior to GEOS 3.8, a function in lwgeom was used. Most recently, measure-\nments and operations on non-planar geometries have been moved from lwgeom to s2 \n(Dunnington et al. 2020; Pebesma and Dunnington 2020). Native support for units \nin sf objects carries through to measurements on outputs of topological operations: > buf_df1 <- st_buffer(df1, dist=0.3)\n> st_area(buf_df1)\nUnits: [m^2]\n[1] 0.2826142 0.2826142 0.2826142\n> plot(st_geometry(buf_df1))\n> plot(st_geometry(df1), add=TRUE, pch=4) 1 3 1 3 3 Progress in the R ecosystem for representing and handling spatial… 527 Fig. 2   Three points and three buffers plotted with geometry-specific plot methods for \"sfc\" objects Fig. 2   Three points and three buffers plotted with geometry-specific plot methods for \"sfc\" objects The sf package provides simple base graphics plotting methods. Those for just \nthe \"sfc\" column retrieved by st_geometry() do not take over the layout of \nthe graphics device, but for the \"sf\" object, they do, showing multiple non-geom-\netry columns in separate displays. Figure 2 shows a simple plot of the three buffer \npolygons overplotted with the three points. 3.2  \u0007Raster representations Like sf, the stars package for scalable, spatio-temporal tidy arrays was supported \nby an R Consortium grant. Spatio-temporal arrays were seen as an alternative way \nof representing multivariate spatio-temporal data from the choices made in the spa-\ncetime package, where a two-dimensional data frame contained stacked observation \npositions in space within stacked time points or intervals. The proposed arrays might \ncollapse to a raster layer if only one variable was chosen for one time point or inter-\nval. More important, the development of the package was extended to accommodate \na backend for earth data processing in which the data are retrieved and re-sampled \nas needed from servers, most often cloud-based servers. In most cases, these would \nbe raster geometries, but the array representation also handles irregular geometries \nthrough time. The R Consortium support was chiefly used to let contributors meet to \nmake progress on concepts and implementation. This example only covers a multiband raster taken from a Landsat 7 view of a small \npart of the Brazilian coast. In the first part, a GeoTIFF file is read into memory, using \nthree array dimensions, two in planar space, the third across six bands: 1 3 1 3 R. S. Bivand 528 > library(stars)\n> fn <- system.file(\"tif/L7_ETMs.tif\", package = \"stars\")\n> L7 <- read_stars(fn)\n> L7\nstars object with 3 dimensions and 1 attribute\nattribute(s): stars object with 3 dimensions and 1 attribute\nattribute(s): L7_ETMs.tif\nMin. :\n1.00\n1st Qu.: 54.00\nMedian : 69.00\nMean\n: 68.91\n3rd Qu.: 86.00\nMax. :255.00\ndimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb L7_ETMs.tif\nMin. :\n1.00\n1st Qu.: 54.00\nMedian : 69.00\nMean\n: 68.91\n3rd Qu.: 86.00\nMax. :255.00\n( ) dimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... 3.2  \u0007Raster representations FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb The bands can be operated on arithmetically, for example to generate a new object \ncontaining values of the normalized difference vegetation index through a function \napplied across the x and y spatial dimensions, using the st_apply abstraction: > ndvi <- function(x) (x[4] - x[3])/(x[4] + x[3])\n> (s2.ndvi <- st_apply(L7, c(\"x\", \"y\"), ndvi))\nstars object with 2 dimensions and 1 attribute\nattribute(s): > (s2.ndvi <- st_apply(L7, c(\"x\", \"y\"), ndvi))\nstars object with 2 dimensions and 1 attribute\nattribute(s):\nndvi\nMin. :-0.75342\n1st Qu.:-0.20301\nMedian :-0.06870\nMean\n:-0.06432\n3rd Qu.: 0.18667\nMax. : 0.58667\ndimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y] ( )\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y] The same file can also be accessed using the proxy mechanism, which creates a link \nto the external entity, here a file: > L7p <- read_stars(fn, proxy=TRUE)\n> L7p\nstars_proxy object with 1 attribute in file:\n$L7_ETMs.tif\n[1] \"[...]/L7_ETMs.tif\"\ndimension(s): > L7p <- read_stars(fn, proxy=TRUE)\n> L7p\nstars_proxy object with 1 attribute in file:\n$L7_ETMs.tif\n[1] \"[...]/L7_ETMs.tif\" [1] \"[...]/L7_ETMs.tif\" dimension(s): ( )\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... 3.2  \u0007Raster representations FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb s\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\n1 352 9120761\n28 5 UTM Z\n25\nS\nh\nH\nFALSE\nNULL [ ] a\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf s\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x] x\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb 3 Progress in the R ecosystem for representing and handling spatial… 529 The same function can also be applied across the same two spatial dimensions \nof the array, but no calculation is carried out until the data are needed and the out-\nput resolution known, with the command needed to create the output stored in the \nobject: > (L7p.ndvi = st_apply(L7p, c(\"x\", \"y\"), ndvi))\nstars_proxy object with 1 attribute in file:\n$L7_ETMs.tif\n[1] \"[...]/L7_ETMs.tif\" > (L7p.ndvi = st_apply(L7p, c(\"x\", \"y\"), ndvi)) > (L7p.ndvi = st_apply(L7p, c(\"x\", \"y\"), ndvi)\nstars_proxy object with 1 attribute in file:\n$L7 ETMs tif p\npp y\np,\n,\ny\n,\nstars_proxy object with 1 attribute in file:\n$L7_ETMs.tif [1] \"[...]/L7_ETMs.tif\" dimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... 3.2  \u0007Raster representations FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb\ncall list:\n[[1]]\nst_apply(X = X, MARGIN = c(\"x\", \"y\"), FUN = ndvi) dimension(s): dimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y]\nL\nL\nU\nN\nA\nN\nA\nN\nA\nN\nA\nN\n6\n1\nd\nn\na\nb\ncall list:\n[[1]]\nst_apply(X = X, MARGIN = c(\"x\", \"y\"), FUN = ndvi) a\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf 1]]\n_apply(X = X, MARGIN = c(\"x\", \"y\"), FUN = ndvi) The array object can also be split, here on the band dimension, to yield a repre-\nsentation as six rasters in list form: > (x6 <- split(L7, \"band\"))\nstars object with 2 dimensions and 6 attributes\nattribute(s): stars object with 2 dimensions and 6 attributes\nattribute(s):\nX1\nX2\nX3\nX4\nMin. : 47.00\nMin. : 32.00\nMin. : 21.00\nMin. :\n9.00\n1st Qu.: 67.00\n1st Qu.: 55.00\n1st Qu.: 49.00\n1st Qu.: 52.00\nMedian : 78.00\nMedian : 66.00\nMedian : 63.00\nMedian : 63.00\nMean\n: 79.15\nMean\n: 67.57\nMean\n: 64.36\nMean\n: 59.24\n3rd Qu.: 89.00\n3rd Qu.: 79.00\n3rd Qu.: 77.00\n3rd Qu.: 75.00\nMax. :255.00\nMax. :255.00\nMax. :255.00\nMax. :255.00\nX5\nX6\nMin. :\n1.00\nMin. :\n1.00\n1st Qu.: 63.00\n1st Qu.: 32.00\nMedian : 89.00\nMedian : 60.00\nMean\n: 83.18\nMean\n: 59.98\n3rd Qu.:112.00\n3rd Qu.: 88.00\nMax. :255.00\nMax. :255.00\ndimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y] X1\nX2\nX3\nX4\nMin. : 47.00\nMin. : 32.00\nMin. : 21.00\nMin. 3.2  \u0007Raster representations :\n9.00\n1st Qu.: 67.00\n1st Qu.: 55.00\n1st Qu.: 49.00\n1st Qu.: 52.00\nMedian : 78.00\nMedian : 66.00\nMedian : 63.00\nMedian : 63.00\nMean\n: 79.15\nMean\n: 67.57\nMean\n: 64.36\nMean\n: 59.24\n3rd Qu.: 89.00\n3rd Qu.: 79.00\n3rd Qu.: 77.00\n3rd Qu.: 75.00\nMax. :255.00\nMax. :255.00\nMax. :255.00\nMax. :255.00\nX5\nX6\nMin. :\n1.00\nMin. :\n1.00\n1st Qu.: 63.00\n1st Qu.: 32.00\nMedian : 89.00\nMedian : 60.00\nMean\n: 83.18\nMean\n: 59.98\n3rd Qu.:112.00\n3rd Qu.: 88.00\nMax. :255.00\nMax. :255.00\ndimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf dimension(s):\ns\ne\nu\nl\na\nv\nt\nn\ni\no\np\ns\ny\ns\nf\ne\nr\na\nt\nl\ne\nd\nt\ne\ns\nf\nf\no\no\nt\nm\no\nr\nf\nx\n1 349\n288776\n28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [x]\ny\n1 352 9120761 -28.5 UTM Zone 25, Southern Hem... FALSE\nNULL [y] These rasters may also be subjected to arithmetical operations, and as may be \nseen, explicit arithmetic on the six rasters has the same outcome as applying the \nsame calculation to the three-dimensional array: 1 3 530 R. S. Bivand > x6$mean <- (x6[[1]] + x6[[2]] + x6[[3]] + x6[[4]] + x6[[5]] + x6[[6]])/6\n> xm <- st_apply(L7, c(\"x\", \"y\"), mean)\n> all.equal(xm[[1]], x6$mean)\n[1] TRUE > x6$mean <- (x6[[1]] + x6[[2]] + x6[[3]] + x6[[4]] + x6[[5]] + x6[[6]])/6\n> xm <- st_apply(L7, c(\"x\", \"y\"), mean)\n> all.equal(xm[[1]], x6$mean)\n[1] TRUE The extension to a gridded temporal dimension or to irregular spatial and tem-\nporal entities is not particularly difficult, but it remains to document the possibili-\nties of the package more fully. 3.3  \u0007Visualization The classInt package (Bivand 2020a) for finding thematic mapping class inter-\nvals is used directly in plot methods in sf and stars, and in the tmap (Tennekes \n2018, 2020) and cartography (Giraud and Lambert 2016, 2017, 2020) packages. Lapa et al. (2001) (Leprosy surveillance in Olinda, Brazil, using spatial analysis \ntechniques) made available the underlying data set of Olinda census tracts (setor) \nin the Corrego Alegre 1970-72 / UTM zone 25S projection (EPSG:22525); we \nwill use the data set and the deprivation variable to point to visualization alterna-\ntives now available. > olinda <- st_read(\"olinda.gpkg\", quiet=TRUE) The style= argument gives the choice of method used for finding the number \nof classes specified, with \"fisher\" being a natural breaks method, and \"bclust\" \nbagged clustering from the e1071 package (Meyer et al. 2019): > library(classInt) > library(classInt)\n> cI_fisher <- classIntervals(olinda$\"DEPRIV\", n=7, style=\"fisher\")\n> set.seed(1)\n> cI_bclust <- classIntervals(olinda$\"DEPRIV\", n=7, style=\"bclust\")\nCommittee Member: 1(1) 2(1) 3(1) 4(1) 5(1) 6(1) 7(1) 8(1) 9(1) 10(1)\nComputing Hierarchical Clustering > cI_bclust <- classIntervals(olinda$\"DEPRIV\", n=7, style=\"bclust\")\nCommittee Member: 1(1) 2(1) 3(1) 4(1) 5(1) 6(1) 7(1) 8(1) 9(1) 10(1)\nComputing Hierarchical Clustering > cI_bclust <- classIntervals(olinda$\"DEPRIV\", n=7, style=\"bclust\")\nCommittee Member: 1(1) 2(1) 3(1) 4(1) 5(1) 6(1) 7(1) 8(1) 9(1) 10(1) Committee Member: 1(1) 2(1) 3(1) 4(1) 5(1) 6(1) 7(1) 8(1) 9(1) 10(1)\nComputing Hierarchical Clustering For a long time, the RColorBrewer package (Neuwirth 2014) colour palettes \nwere the obvious choice for thematic cartography, but more recently other packages, \nsuch as rcartocolor (Nowosad 2019), have become available, often as supersets of \nthe RColorBrewer palettes: > pal <- rcartocolor::carto_pal(7, \"SunsetDark\")\n> plot(cI_fisher, pal, xlab=\"DEPRIV\", ylab=\"\")\n> plot(cI_bclust, pal, xlab=\"DEPRIV\", ylab=\"\") > pal <- rcartocolor::carto_pal(7, \"SunsetDark\") > plot(cI_fisher, pal, xlab=\"DEPRIV\", ylab=\"\")\n> plot(cI_bclust, pal, xlab=\"DEPRIV\", ylab=\"\") Figure 3 shows plots of the two class interval schemes, with obvious differences \nbetween the two styles. Both styles are attempting to balance low within-class vari-\nance and high between-class variance. 1 3 1 3 Progress in the R ecosystem for representing and handling spatial… 531 0.0\n0.2\n0.4\n0.6\n0.8\n1.0\n0.0\n0.2\n0.4\n0.6\n0.8\n1.0\nfisher\n0.0\n0.2\n0.4\n0.6\n0.8\n1.0\n0.0\n0.2\n0.4\n0.6\n0.8\n1.0\nbclust\nFig. 3   Deprivation by census tract in Olinda, Brazil; empirical cumulative distribution function and class \nintervals for two class intervals: left panel: natural breaks; right panel: bagged clustering Fig. 3   Deprivation by census tract in Olinda, Brazil; empirical cumulative distribution function and class \nintervals for two class intervals: left panel: natural breaks; right panel: bagged clustering Figure 4 shows maps of the same variable with the same class intervals chosen \ninternally using classInt functionality, with the same palette. The syntax is a little \ndifferent, and here, the sf plot method default key has been turned off to permit \nside-by-side display. This method is really best at providing glimpses of the data, \nrather than at creating complete figures, in contrast to the richer functions in cartog-\nraphy; both use base graphics. Fig. > plot(olinda[,\"DEPRIV\"], nbreaks=7, breaks=\"fisher\", pal=pal, key.pos=NULL,\n+\nmain=\"\")\n> library(cartography)\n> choroLayer(olinda, var=\"DEPRIV\", method=\"fisher-jenks\", nclass=7, col=pal,\n+\nlegend.values.rnd=3) > olinda <- st_read(\"olinda.gpkg\", quiet=TRUE) 6   Thematic maps with ggplot2: left panel: default map of a continuous variable; right panel: grati-\ncule removed and palette modified Fig. 7   Thematic maps with ggplot2, natural breaks class intervals: left panel: natural breaks class inter-\nvals; right panel: bagged clustering class intervals Fig. 7   Thematic maps with ggplot2, natural breaks class intervals: left panel: natural breaks class inter-\nvals; right panel: bagged clustering class intervals We can also display the bagged clustering class intervals beside the natural \nbreaks map, again using ggplot2; Figure 7 shows the maps, but because a con-\ntinuous scale is still enforced, all that changes is the position of the breaks on \nthe key. > g3 <- g1 + theme_void() + scale_fill_gradientn(colours=pal,\n+\nbreaks=round(cI_bclust$brks, 3)) > g3 <- g1 + theme_void() + scale_fill_gradientn(colours=pal,\n+\nbreaks=round(cI_bclust$brks, 3)) > olinda <- st_read(\"olinda.gpkg\", quiet=TRUE) 4   Deprivation by census tract in Olinda, Brazil, natural breaks class intervals; left panel: sf plot \nmethod; right panel: cartography choropleth map Fig. 4   Deprivation by census tract in Olinda, Brazil, natural breaks class intervals; left panel: sf plot \nmethod; right panel: cartography choropleth map 3 532 R. S. Bivand Fig. 5   tmap output, natural breaks class intervals; left panel: object o1 without boundaries; right panel: \nobject o2 with boundaries Fig. 5   tmap output, natural breaks class intervals; left panel: object o1 without boundaries; right panel: \nobject o2 with boundaries Figure 5 shows how tmap functions use grid graphics to permit graphics objects to \nbe updated and then plotted using tmap_arrange(). Once again, the same class \nintervals are chosen internally using classInt, with the same palette. The left panel is \nupdated on the right to add thin boundaries between census tracts. tmap also offers \nsmall multiples of facets, for example thematic maps of the same variable observed at \nsuccessive time periods using the same class intervals. An extensive discussion of the \nuse of tmap is provided by Lovelace et al. (2019). > library(tmap)\n> o1 <- tm_shape(olinda) + tm_fill(\"DEPRIV\", style=\"fisher\", n=7, palette=pal)\n> o2 <- o1 + tm_borders(lwd=0.8) > library(tmap)\n> o1 <- tm_shape(olinda) + tm_fill(\"DEPRIV\", style=\"fisher\", n=7, palette=pal)\n> o2 <- o1 + tm_borders(lwd=0.8) > library(tmap) The ggplot2 package (Wickham et al. 2020) provides the geom_sf() facil-\nity for mapping sf objects: > library(ggplot2)\n> g1 <- ggplot(olinda) + geom_sf(aes(fill=DEPRIV))\n> g2 <- g1 + theme_void() + scale_fill_gradientn(colours=pal,\n+\nbreaks=round(cI_fisher$brks, 3)) This approach also builds on grid graphics. It is possible to set a theme that \ndrops the arguably unnecessary graticule, but there is a lot of intervention \nrequired to get a simple map. To get proper class intervals involves even more \nwork, because the package takes specific, not general, positions on how graphics \nare observed. ColorBrewer, for example, eschews continuous colour scales based \non cognitive research, but ggplot2 enforces them by default for continuous vari-\nables. Figure 6 shows the default choice of palette, updated to remove the unnec-\nessary graticule and to use the user-specified palette and class intervals: 1 3 1 3 3 Progress in the R ecosystem for representing and handling spatial… 533 Fig. 6   Thematic maps with ggplot2: left panel: default map of a continuous variable; right panel: grati-\ncule removed and palette modified Fig. 3.4  \u0007Reverse dependencies of the sp and sf packages R packages can possess forward or reverse dependencies. Forward or upstream \ndependencies are typically on R itself, a small number of packages whose func-\ntionalities are used in the package in question (by loading and attaching the pack-\nage (dependencies) or just loading the namespace of the package (imports)), and \npossibly external software libraries. Reverse or downstream dependencies are \npackages that themselves use the package in question by loading and attaching \nit, only loading its namespace or using it on demand (suggests). sp and sf were \nwritten carefully to minimize forward dependencies, with sp only depending on \nand importing packages included in every R distribution by default and sf adding \nCRAN contributed packages Rcpp and units required to build the package and 1 3 3 534 R. S. Bivand classInt for class intervals, DBI for interfacing spatial databases and magrittr \nfor piped operations, where none of these extra forward dependencies draws in \nmany other packages. classInt for class intervals, DBI for interfacing spatial databases and magrittr \nfor piped operations, where none of these extra forward dependencies draws in \nmany other packages. In sp, the compiled code (written in C) is self-contained and is made available to \nother packages, chiefly rgdal and rgeos, to link to their compiled code. rgdal links \nto sp and to the external libraries PROJ and GDAL. GDAL itself links to PROJ and \ncan link to GEOS and many other libraries needed for specific drivers. The external \nsoftware versions used may be reported using *_extSoftVersion, here using \nthe :: operator to avoid attaching the packages being queried: > rgdal::rgdal_extSoftVersion()\nGDAL GDAL_with_GEOS\nPROJ\nsp\n\"3.1.2\"\n\"TRUE\"\n\"7.1.0\"\n\"1.4-4\" The versions vary between platforms and by the installation method used; as \npackage maintainer, I often run with pre-release or latest versions of external soft-\nware to attempt to detect and mitigate changes before they impact users’ workflows. For rgdal, the versions of GDAL, PROJ and sp are reported, together with a test \nshowing whether GDAL was built linking to GEOS, something that affects the \nbehaviour of some drivers. The report for rgeos is simpler, only listing the versions \nof GEOS itself and sp. 3.4  \u0007Reverse dependencies of the sp and sf packages > rgeos::rgeos_extSoftVersion()\nGEOS\nsp\n\"3.8.1\" \"1.4-4\" In the case of sf, and because it brings together access to the GDAL and GEOS \nexternal libraries through Simple Features representation for vector objects, the \nexternal software versions supported are the union of those seen above, omitting \nlinkage to a separate package defining classes for objects. In addition, it reports \nwhich API is used for PROJ, either proj.h or not (the earlier proj_api.h). > sf_extSoftVersion()\nGEOS\nGDAL\nproj.4 GDAL_with_GEOS\nUSE_PROJ_H\n\"3.8.1\"\n\"3.1.2\"\n\"7.1.0\"\n\"true\"\n\"true\" Table 1 shows the structure of reverse dependency counts for sp and sf. Recursive \ndependencies traverse through the whole CRAN dependency tree; the first column \nof the table shows counts of “depends” and “imports” dependencies counted across \nthe whole tree. These split into 1285 only involving sp, 232 involving both pack-\nages and 65 only involving sf. If we additionally include “suggests” dependencies, \nboth packages may be used at least indirectly by all CRAN packages. The two right \ncolumns show the same counts, but only for packages’ first-order dependencies on \nsp, sf or both. We can note that of these for “depends” and “imports” dependencies, \n459 only involve sp, 63 involve both packages and 121 only involve sf. In the first 1 3 Progress in the R ecosystem for representing and handling spatial… Progress in the R ecosystem for representing and handling spatial…\nTable 1   Reverse dependency \ncounts for sp and sf, August \n2020, for recursive and non-\nrecursive reverse dependencies \ntaken as “Depends” and \n“Imports” only, and with \n“Suggests”\nRecursive\nRecursive \nw/suggests\nNot recursive\nNot recursive \nw/suggests\nSum sp\n1517\n16,619\n522\n629\nSum sf\n297\n16,619\n184\n277\nOnly sp\n1285\n0\n459\n513\nOnly sf\n65\n0\n121\n161\nBoth\n232\n16,619\n63\n116\n535 535 column, the number of packages only depending on sf is less than when we ignore \nrecursive dependencies in the third column, which is packages using sf that also use \nsp. The number of packages only using sf is encouraging, given that it first entered \nCRAN in October 2016. It is also encouraging that a fair number of these packages use both sp and sf, \nshowing existing packages are preserving legacy workflows, but also opening up for \nmore modern object representations. It takes time and effort to communicate the \ndesirability of migrating from sp representations to sf and probably stars. 3.4  \u0007Reverse dependencies of the sp and sf packages Although \nkeeping the R code running is feasible, including compiled code not using external \nsoftware, migration to sf is advisable. 4  \u0007Upstream software dependencies of the R‑spatial ecosystem When changes occur in upstream external software, R packages using these libraries \noften need to adapt, but package maintainers try very hard to shield users from any \nnegative consequences, so that legacy workflows continue to provide the same or \nat least similar results from the same data. The code shown in Bivand et al. (2008, \n(2013) is almost all run nightly on a platform with updated R packages and external \nsoftware. This does not necessarily trap all differences (figures are not compared), \nbut is helpful in detecting impacts of changes in packages or external software. It is \nalso very helpful that CRAN servers using the released and development versions of \nR, and with different versions of external software, also run nightly checks. Again, \nsometimes changes are only noticed by users, but quite often checks run by main-\ntainers and by CRAN alert us to impending challenges. Tracking the development \nmailing lists of the external software communities, all open source, can also show \nhow thinking is evolving. However, sometimes code tidying in external software \ncan have unexpected consequences, breaking not sf or sp with rgdal or rgeos, but a \npackage further downstream. Bivand (2014) discusses open-source geospatial soft-\nware stacks more generally, but here we will consider ongoing changes in PROJ and \nlinked changes in GDAL. We will use the example of the location of the Broad Street pump in Soho, London, \nrelated to the 1854 Cholera epidemic and Dr John Snow’s intervention Brody et al. 1 3 536 R. S. Bivand (2000), distributed with sf (from version 0.8–1). Although it was known that changes in \nupstream software would impact workflows, the extent of those impacts became clear \nusing a standard example following upgrading to PROJ 6 and GDAL 3 in 2019: (2000), distributed with sf (from version 0.8–1). Although it was known that changes in \nupstream software would impact workflows, the extent of those impacts became clear \nusing a standard example following upgrading to PROJ 6 and GDAL 3 in 2019: > bp_file <- system.file(\"gpkg/b_pump.gpkg\", package=\"sf\")\n> b_pump_sf <- st_read(bp_file, quiet=TRUE) > bp_file <- system.file(\"gpkg/b_pump.gpkg\", package=\"sf\")\n> b_pump_sf <- st_read(bp_file, quiet=TRUE) Before R packages upgraded the way coordinate reference systems were represented \nin early 2020, our Proj4 string representation suffered degradation. Taking the Proj4 \nstring defined in PROJ 5 for the British National Grid, we can see a +datum=OSGB36 \nkey–value pair. 4  \u0007Upstream software dependencies of the R‑spatial ecosystem But when processing this input with PROJ 6 and GDAL 3, this key is \nremoved. Checking, we can see that reading the input string appears to work, but the \noutput for the Proj4 string drops the +datum=OSGB36 key–value pair, introducing \ninstead the ellipse implied by that datum: > proj5 <- paste0(\"+proj=tmerc +lat_0=49 +lon_0=-2 +k=0.9996012717\",\n+\n\" +x_0=400000 +y_0=-100000 +datum=OSGB36 +units=m +no_defs\")\n> legacy <- st_crs(proj5)\n> proj6 <- legacy$proj4string\n> proj5_parts <- unlist(strsplit(proj5, \" \"))\n> proj6_parts <- unlist(strsplit(proj6, \" \"))\n> proj5_parts[!is.element(proj5_parts, proj6_parts)]\n[1] \"+datum=OSGB36\"\n> proj6_parts[!is.element(proj6_parts, proj5_parts)]\n[1] \"+ellps=airy\" > proj5 <- paste0(\"+proj=tmerc +lat_0=49 +lon_0=-2 +k=0.9996012717\n+\n\" +x_0=400000 +y_0=-100000 +datum=OSGB36 +units=m +no_defs\")\n> legacy <- st_crs(proj5)\n> proj6 <- legacy$proj4string\n> proj5_parts <- unlist(strsplit(proj5, \" \"))\n> proj6_parts <- unlist(strsplit(proj6, \" \"))\n> proj5_parts[!is.element(proj5_parts, proj6_parts)]\n[1] \"+datum=OSGB36\"\n> proj6_parts[!is.element(proj6_parts, proj5_parts)]\n[1] \"+ellps=airy\" We can emulate the problem seen following the release in May 2019 of GDAL 3.0.0 \nusing PROJ 6, by inserting the degraded Proj4 string into the Broad Street pump object. The coordinate reference system representation is now ignorant of the proper datum \nspecification: > b_pump_sf1 <- b_pump_sf > b_pump_sf1 <- b_pump_sf _p\np_\n_p\np_\n> st_crs(b_pump_sf1) <- st_crs(st_crs(b_pump_sf1)$proj4string) p\np\np\np\n> st_crs(b_pump_sf1) <- st_crs(st_crs(b_pump_sf1)$proj4string) > st_crs(b_pump_sf1) <- st_crs(st_crs(b_pump_sf1)$proj4string) Why does this matter? For visualization on a web map, for example using the \nmapview package, the projected geometries are transformed to the same WGS84 \nellipse and datum (EPSG:4326) that were used in PROJ 4 as a transformation hub. In leaflet, these are projected to Web Mercator (EPSG:3857). In mapview(), the \nsf::st_transform() function is used, so we will emulate this step before hand-\ning on the geometries for display. 4  \u0007Upstream software dependencies of the R‑spatial ecosystem The projected British National Grid point location is \nunchanged: 1 3 1 3 Progress in the R ecosystem for rep\n> all.equal(st_coordinate\n+\nst_coordinate\n[1] TRUE\nHowever, because the \nresentation of its coordin\nformed identically to WG\nFigure 8:\n> b_pump_sf_ll <- st_tran\n> b_pump_sf1_ll <- st_tra\n> st_distance(b_pump_sf_l\nUnits: [m]\n[,1]\n[1,] 125.0578 Progress in the R ecosystem for representing and handling spatial… 537 > all.equal(st_coordinates(st_geometry(b_pump_sf)),\n+\nst_coordinates(st_geometry(b_pump_sf1)))\n[1] TRUE However, because the one of the objects now has a degraded Proj4 string rep-\nresentation of its coordinate reference system, the output points, apparently trans-\nformed identically to WGS84, are now some distance apart, as is also shown in \nFigure 8: > b_pump_sf_ll <- st_transform(b_pump_sf, 4326)\n> b_pump_sf1_ll <- st_transform(b_pump_sf1, 4326)\n> st_distance(b_pump_sf_ll, b_pump_sf1_ll)\nUnits: [m]\n[,1]\n[1,] 125.0578 > b_pump_sf_ll <- st_transform(b_pump_sf, 4326) [,1]\n[1,] 125.0578 Once PROJ 6 and GDAL 3 had stabilized in the summer of 2019, we iden-\ntified the underlying threat as lying in the advertised degradation of GDAL’s \nexportToProj4() function. When reading raster and vector files, the coordinate ref-\nerence system representation using Proj4 strings would often be degraded, so that fur-\nther transformation within R (also using GDAL/PROJ functionality) would be at risk of \nmuch greater inaccuracy than with PROJ 5 and GDAL 2. Since then, sf, sp with rgdal Fig. 8   Displays made using mapview displays of the Broad Street pump, with the green point within 2 m \nof the pump location, and the red point in Ingestre Place because of the loss of the datum specification Fig. 8   Displays made using mapview displays of the Broad Street pump, with the green point within 2 m \nof the pump location, and the red point in Ingestre Place because of the loss of the datum specification Fig. 8   Displays made using mapview displays of the Broad Street pump, with the green point within 2 m \nof the pump location, and the red point in Ingestre Place because of the loss of the datum specification 1 3 3 538 R. S. 7  https​://cran.r-proje​ct.org/web/packa​ges/rgdal​/vigne​ttes/CRS_proje​ction​s_trans​forma​tions​.html. 6  https​://www.r-spati​al.org/r/2020/03/17/wkt.html.\n7 8  State of https​://githu​b.com/rsbiv​and/sp of 18 August 2020 or later. 4  \u0007Upstream software dependencies of the R‑spatial ecosystem Bivand and raster have adopted the 2019 version of the “Well-Known Text” coordinate refer-\nence system representation WKT2-2019 (ISO 2019) instead of Proj4 strings to contain \ncoordinate reference system definitions.6 Accommodations have also been provided so \nthat the S3 class \"crs\" objects used in objects defined in sf, and the formal S4 class \n\"CRS\" objects used objects defined in sp and raster, can continue to attempt to support \nProj4 strings in addition, while other package maintainers and workflow users catch up.7 l\nFollowing an extended campaign of checking about 900 reverse dependencies \n(packages depending on sp, rgdal and others) and dozens of github issues, most of \nthe consequences of the switch to WKT2 among packages have now been addressed. Most recently (late August 2020), 115 packages have been offered rebuilt stored \nobjects that had included \"CRS\" objects without WKT2 definitions. i\nThis approach has ensured that spatial objects, whether created within R, read in from \nexternal data sources or read as stored objects, all have WKT2 string representations of \ntheir coordinate reference systems, and for backward compatibility can represent these in \naddition as Proj4 strings. Operations on objects should carry forward the new represen-\ntations, which should be written out to external data formats correctly. There is a minor \ndivergence between sf and sp (and thus rgdal): In sf, the axis order of the CRS is pre-\nserved as instantiated, but objects do not have their axes swapped to accord with authori-\nties unless sf::st_axis_order() is set TRUE. This can appear odd, because \nalthough the representation records a northings–eastings axis order, data are treated as \neastings–northings in plotting, variogram construction and so on: > st_crs(\"EPSG:4326\")\nCoordinate Reference System:\nUser input: EPSG:4326\nwkt:\nGEOGCRS[\"WGS 84\",\nDATUM[\"World Geodetic System 1984\",\nELLIPSOID[\"WGS 84\",6378137,298.257223563,\nLENGTHUNIT[\"metre\",1]]],\nPRIMEM[\"Greenwich\",0,\nANGLEUNIT[\"degree\",0.0174532925199433]],\nCS[ellipsoidal,2],\nAXIS[\"geodetic latitude (Lat)\",north,\nORDER[1],\nANGLEUNIT[\"degree\",0.0174532925199433]],\nAXIS[\"geodetic longitude (Lon)\",east,\nORDER[2],\nANGLEUNIT[\"degree\",0.0174532925199433]], ANGLEUNIT[\"degree\",0.0174532925199433]], ANGLEUNIT[\"degree\",0.0174532925199433]] g\nUSAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]],\nID[\"EPSG\",4326]] g\nUSAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]],\nID[\"EPSG\",4326]] USAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]],\nID[\"EPSG\",4326]] USAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]],\nID[\"EPSG\",4326]] ID[\"EPSG\",4326]] In sp/rgdal, attempts are made to ensure that axis order is in the form termed \nGIS, traditional or visualization that is always eastings–northings: 1 3 Progress in the R ecosystem for representing and handling spatial… > library(sp)\n> cat(wkt(CRS(\"EPSG:4326\")))\nGEOGCRS[\"WGS 84\",\nDATUM[\"World Geodetic System 1984\",\nELLIPSOID[\"WGS 84\",6378137,298.257223563,\nLENGTHUNIT[\"metre\",1]],\nID[\"EPSG\",6326]],\nPRIMEM[\"Greenwich\",0,\nANGLEUNIT[\"degree\",0.0174532925199433],\nID[\"EPSG\",8901]],\nCS[ellipsoidal,2],\nAXIS[\"longitude\",east,\nORDER[1],\nANGLEUNIT[\"degree\",0.0174532925199433,\nID[\"EPSG\",9122]]],\nAXIS[\"latitude\",north,\nORDER[2],\nANGLEUNIT[\"degree\",0.0174532925199433,\nID[\"EPSG\",9122]]],\nUSAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]]] > library(sp)\n> cat(wkt(CRS(\"EPSG:4326\")))\nGEOGCRS[\"WGS 84\",\nDATUM[\"World Geodetic System 1984\",\nELLIPSOID[\"WGS 84\",6378137,298.257223563,\nLENGTHUNIT[\"metre\",1]],\nID[\"EPSG\",6326]],\nPRIMEM[\"Greenwich\",0,\nANGLEUNIT[\"degree\",0.0174532925199433],\nID[\"EPSG\",8901]],\nCS[ellipsoidal,2],\nAXIS[\"longitude\",east,\nORDER[1],\nANGLEUNIT[\"degree\",0.0174532925199433,\nID[\"EPSG\",9122]]],\nAXIS[\"latitude\",north,\nORDER[2],\nANGLEUNIT[\"degree\",0.0174532925199433,\nID[\"EPSG\",9122]]],\nUSAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]]] Progress in the R ecosystem for representing and handling spatial… 539 9  nl is used to represent the verbatim new line character in the processed article. USAGE[ USAGE[\nSCOPE[\"unknown\"],\nAREA[\"World\"],\nBBOX[-90,-180,90,180]]] The probability of confusion increases when coercing from sf to sp and vice \nversa, with the representations most often remaining unchanged.8 > sf_from_sp <- st_crs(CRS(\"EPSG:4326\"))\n> o <- strsplit(sf_from_sp$wkt, nl)[[1]]\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl))\nCS[ellipsoidal,2],\nAXIS[\"longitude\",east,\nORDER[1],\nAXIS[\"latitude\",north,\nORDER[2], > sf_from_sp <- st_crs(CRS(\"EPSG:4326\"))\n> o <- strsplit(sf_from_sp$wkt, nl)[[1]]\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl))\nCS[ellipsoidal,2],\nAXIS[\"longitude\",east,\nORDER[1],\nAXIS[\"latitude\",north,\nORDER[2], > sf_from_sp <- st_crs(CRS(\"EPSG:4326\")) o <- strsplit(sf_from_sp$wkt, nl)[[1]] p\np\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl)) (p\n( [g\np(\n|\n|\nCS[ellipsoidal,2],\nAXIS[\"longitude\",east,\nORDER[1],\nAXIS[\"latitude\",north,\nORDER[2], > sp_from_sf <- as(st_crs(\"EPSG:4326\"), \"CRS\")\n> o <- strsplit(wkt(sp_from_sf), nl)[[1]]\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl))\nCS[ellipsoidal,2],\nAXIS[\"geodetic latitude (Lat)\",north,\nORDER[1],\nAXIS[\"geodetic longitude (Lon)\",east,\nORDER[2], > sp_from_sf <- as(st_crs(\"EPSG:4326\"), \"CRS\") > sp_from_sf <- as(st_crs(\"EPSG:4326\"), \"CRS\")\n> o <- strsplit(wkt(sp_from_sf), nl)[[1]]\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl)\nCS[ellipsoidal,2],\nAXIS[\"geodetic latitude (Lat)\",north,\nORDER[1],\nAXIS[\"geodetic longitude (Lon)\",east,\nORDER[2], > o <- strsplit(wkt(sp_from_sf), nl)[[1]] p\np\n> cat(paste(o[grep(\"CS|AXIS|ORDER\", o)], collapse=nl)) Both of these coercions are using the same underlying PROJ and GDAL versions, \nand the same PROJ metadata. Once work in progress is completed, coercions should \nrespect the setting of sf::st_axis_order(). 1 3 540 R. S. Bivand It may useful for users to know of other differences between sf and sp/rgdal. Transformation in sf uses code in GDAL, which in turn uses functions in PROJ; in \nsp/rgdal, PROJ is used directly for transformation. In order to demonstrate more of \nwhat is happening, let us coerce these sf objects to sp (they are both planar with an \nx–y axis order): > b_pump_sp <- as(b_pump_sf, \"Spatial\")\n> b_pump_sp1 <- as(b_pump_sf1, \"Spatial\") > b_pump_sp <- as(b_pump_sf, \"Spatial\")\n> b_pump_sp1 <- as(b_pump_sf1, \"Spatial\") We will also set up a temporary directory for use with the on-demand grid down-\nload functionality in PROJ 7; this must be done before rgdal is loaded: > td <- tempfile()\n> dir.create(td)\n> Sys.setenv(\"PROJ_USER_WRITABLE_DIRECTORY\"=td)\n> library(rgdal) > td <- tempfile()\n> dir.create(td)\n> Sys.setenv(\"PROJ_USER_WRITABLE_DIRECTORY\"=td)\n> library(rgdal) > td <- tempfile()\n> dir.create(td)\n> Sys.setenv(\"PROJ_USER_WRITABLE_DIRECTORY\"=td)\n> library(rgdal) > td <- tempfile() > td <- tempfile()\n> dir.create(td)\n( > dir.create(td) > library(rgdal) In sf, areas of interest need to be given by the users, while in transformation and \nprojection in rgdal, these are calculated from the object being projected or trans-\nformed. The provision of areas of interest is intended to reduce the number of candi-\ndate coordinate operations found by PROJ. USAGE[ > WKT <- wkt(b_pump_sp)\n> o <- list_coordOps(WKT, \"EPSG:4326\")\n> c(nrow(o), nrow(o[o$instantiable,]), sum(o$number_grids))\n[1] 8 7 1\n> aoi0 <- project(t(unclass(bbox(b_pump_sp))), WKT, inv=TRUE)\n> aoi <- c(t(aoi0 + c(-0.1, +0.1)))\n> o_aoi <- list_coordOps(WKT, \"EPSG:4326\", area_of_interest=aoi)\n> c(nrow(o_aoi), nrow(o_aoi[o_aoi$instantiable,]), sum(o_aoi$number_grids))\n[1] 5 4 1 rgdal::list_coordOps() accesses the PROJ metadata database to \nsearch through candidate coordinate operations, ranking them by accuracy, \nreturning a data frame of operations. When an area of interest is provided, candi-\ndates falling outside it are dropped. Coordinate operations that cannot be instanti-\nated because of missing grids are also listed. We can see here that when an area \nof interest is not given, 8 candidate operations are found when the WKT string \ncontains datum information. Of these, 7 may be instantiated, with 1 needing a \ngrid (here, the operation that cannot be instantiated). Three operations cease to be \ncandidates if we use an area of interest. In sp/rgdal, the coordinate operation last used is returned and can be retrieved \nusing rgdal::get_last_coordOp(); coordinate operations are repre-\nsented as pipelines (Knudsen and Evers 2017; Evers and Knudsen 2017), intro-\nduced in PROJ 5 and using the PROJ key–value pair notation:9 1 3 1 3 Progress in the R ecosystem for representing and handling spatial… 541 > b_pump_sp_ll <- spTransform(b_pump_sp, \"EPSG:4326\")\n> cat(strwrap(get_last_coordOp()), sep=nl)\n+proj=pipeline +step +inv +proj=tmerc +lat_0=49 +lon_0=-2 +k=0.999601\n+x_0=400000 +y_0=-100000 +ellps=airy +step +proj=push +v_3 +step +proj=cart\n+ellps=airy +step +proj=helmert +x=446.448 +y=-125.157 +z=542.06 +rx=0.15\n+ry=0.247 +rz=0.842 +s=-20.489 +convention=position_vector +step +inv\n+proj=cart +ellps=WGS84 +step +proj=pop +v_3 +step +proj=unitconvert\n+xy_in=rad +xy_out=deg > b_pump_sp_ll <- spTransform(b_pump_sp, \"EPSG:4326\")\n> cat(strwrap(get_last_coordOp()), sep=nl)\n+proj=pipeline +step +inv +proj=tmerc +lat_0=49 +lon_0=-2 +k=0.999601\n+x_0=400000 +y_0=-100000 +ellps=airy +step +proj=push +v_3 +step +proj=cart\n+ellps=airy +step +proj=helmert +x=446.448 +y=-125.157 +z=542.06 +rx=0.15\n+ry=0.247 +rz=0.842 +s=-20.489 +convention=position_vector +step +inv\n+proj=cart +ellps=WGS84 +step +proj=pop +v_3 +step +proj=unitconvert\n+xy_in=rad +xy_out=deg > b_pump_sp_ll <- spTransform(b_pump_sp, \"EPSG:4326\") > b_pump_sp_ll <- spTransform(b_pump_sp, \"EPSG:4326\") > b_pump_sp_ll <- spTransform(b_pump_sp, \"EP\n> cat(strwrap(get_last_coordOp()), sep=nl) p\np\np\np\np\np\np\n> cat(strwrap(get_last_coordOp()), sep=nl) +proj=pipeline +step +inv +proj=tmerc +lat_0=49 +lon_0=-2 +k=0.999601\n+x_0=400000 +y_0=-100000 +ellps=airy +step +proj=push +v_3 +step +proj=cart\n+ellps=airy +step +proj=helmert +x=446.448 +y=-125.157 +z=542.06 +rx=0.15\n+ry=0.247 +rz=0.842 +s=-20.489 +convention=position_vector +step +inv\n+proj=cart +ellps=WGS84 +step +proj=pop +v_3 +step +proj=unitconvert\n+xy_in=rad +xy_out=deg Here, we can see that an inverse projection from the specified Transverse Mer-\ncator projection is made to geographical coordinates, followed by a seven-param-\neter Helmert transformation to WGS84 ellipsoid and datum. 10  https​://cdn.proj.org. > enable_proj_CDN()\n[1] \"Using: /tmp/Rtmp5keMtw/file1c4592b3b37c2\"\n> list.files(td)\ncharacter(0) > o <- list_coordOps(WKT, \"EPSG:4326\", area_of_interest=aoi)\n> c(nrow(o), nrow(o[o$instantiable,]), sum(o$number_grids))\n[1] 5 5 1 > o <- list_coordOps(WKT, \"EPSG:4326\", area_of_interest=aoi)\n> c(nrow(o), nrow(o[o$instantiable,]), sum(o$number_grids))\n[1] 5 5 1 > o <- list_coordOps(WKT, \"EPSG:4326\", area_of_interest=aoi)\n> c(nrow(o), nrow(o[o$instantiable,]), sum(o$number_grids))\n[1] 5 5 1 > b_pump_sp_llg <- spTransform(b_pump_sp, \"EPSG:4326\") > cat(strwrap(get_last_coordOp()), sep=nl) +proj=pipeline +step +inv +proj=tmerc +lat_0=49 +lon_0=-2 +k=0.999601 +x_0=400000 +y_0=-100000 +ellps=airy +step +proj=hgridshift +grids=uk_os_OSTN15_NTv2_OSGBtoETRS.tif +step +proj=unitconvert +xy_in=rad\n+xy_out=deg Now the downloaded grid is cached in the database in the designated CDN direc-\ntory and may be used for other transformations using the same operation. > list.files(td)\n[1] \"cache.db\"\n> file.size(file.path(td, list.files(td)[1]))\n[1] 319488\n> disable_proj_CDN() > list.files(td)\n[1] \"cache.db\"\n> file.size(file.path(td, list.files(td)[1]))\n[1] 319488\n> disable_proj_CDN() Once again, the distance between the point transformed from the sf object as read \nfrom file and the point with the degraded coordinate reference system emulating the \neffect of the change in behaviour of GDAL’s exportToProj4() in GDAL 6 and \nlater is about 125 m. Using the CDN shifts the output point by 1.7 m. For confirma-\ntion, the output transformed coordinates for the sp and sf objects using the Helmert \ntransformation are the same. > c(spDists(b_pump_sp1_ll, b_pump_sp_ll),\n+\nspDists(b_pump_sp_llg, b_pump_sp_ll))*1000\n[1] 125.057683\n1.751474\n> all.equal(unname(coordinates(b_pump_sp_ll)),\n+\nunname(st_coordinates(st_geometry(b_pump_sf_ll))))\n[1] TRUE > c(spDists(b_pump_sp1_ll, b_pump_sp_ll),\n+\nspDists(b_pump_sp_llg, b_pump_sp_ll))*1000\n[1] 125.057683\n1.751474\n> all.equal(unname(coordinates(b_pump_sp_ll)),\n+\nunname(st_coordinates(st_geometry(b_pump_sf_ll))))\n[1] TRUE > c(spDists(b_pump_sp1_ll, b_pump_sp_ll),\n+\nspDists(b_pump_sp_llg, b_pump_sp_ll))*1000\n[1] 125.057683\n1.751474\n> all.equal(unname(coordinates(b_pump_sp_ll)),\n+\nunname(st_coordinates(st_geometry(b_pump_sf_ll))))\n[1] TRUE Although it appears that most of the consequences of the change in representa-\ntion of coordinate reference systems from Proj4 to WKT2 strings have now been \naddressed, we still see signs on the mailing list and on Twitter that users, natu-\nrally directing their attention to their analytical or visualization work, may still \nbe confused. The extent of the spatial cluster of R packages is so great that it will \nundoubtedly take time before the dust settles. However, we trust that the operation \nof upgrading representations is now largely complete. Multiple warnings issued in \nsp workflows, now noisily drawing attention to possible degradations in workflows, \nwill by default be muted when sp 1.5 and rgdal 1.6 are released. USAGE[ The parameters are \ncontained in the best instantiable coordinate operation retrieved from the PROJ \ndatabase. > o <- list_coordOps(wkt(b_pump_sp1), \"EPSG:4326\", area_of_interest=aoi)\n> cat(nrow(o), o$ballpark, nl)\n1 TRUE > b_pump_sp1_ll <- spTransform(b_pump_sp1, \"EPSG:4326\") > cat(strwrap(get_last_coordOp()), sep=nl) Going on to the case of the degraded representation, only 1 operation is found, \nwith only ballpark accuracy. With our emulation of the dropping of +datum= sup-\nport in GDAL’s exportToProj4(), we see that the coordinate operation pipe-\nline only contains the inverse projection step, accounting for the observed shift of \nthe Broad Street pump to Ingestre Place. Finally, sp/rgdal may use the provision of on-demand downloading of transfor-\nmation grids to provide more accuracy (CDN, from PROJ 7).10 Before finding and \nchoosing to use a coordinate operation using an on-demand downloaded grid, the \ndesignated directory is empty: > enable_proj_CDN()\n[1] \"Using: /tmp/Rtmp5keMtw/file1c4592b3b37c2\"\n> list.files(td)\ncharacter(0) Using the CDN, all the candidate operations are instantiable, and the pipeline \nnow shows a horizontal grid transformation rather than a Helmert transformation. 1 3 R. S. Bivand 542 5  \u0007Outlook As has already been mentioned, either most sp-based workflows continue to func-\ntion using sf objects or changes have been made in packages like spdep and its mod-\nelling counterpart spatialreg to permit scripts and packages using these packages \nto continue to function. Some workflows require more attention than others, but 1 3 Progress in the R ecosystem for representing and handling spatial… 543 the transition to sf from sp, rgdal and rgeos should be unproblematic. Shifting to \nnew visualization packages like tmap, cartography and mapview should also be \nrelatively easy, and use of sf and the new visualization packages should certainly \nbecome standard for new research and teaching. It may take a little longer for stars \nto find its place, but work here is continuing, and will stabilize before long. Similar \nremarks apply to transition from raster to terra. The key challenges for handling spatial data using R concern the upstream \nsoftware libraries in the open-source geospatial software stack, not just PROJ as \ndescribed above or changes in validity requirements in GEOS and other libraries, \nbut also the opportunities opened up by access to cloud-based earth observation data \nstreams. Because incoming data may take forms as yet not provided for, even where \nGDAL drivers become available, changes in object representations may become \nnecessary. In particular, this relates to spatio-temporal data, where trajectory data \nare especially demanding. These data representation challenges are actually oppor-\ntunities for users and developers to continue cooperating to contribute to making the \nR ecosystem for handling and analysing spatial and spatio-temporal data even more \ncapable and performant. Finally, please note that a CODECHECK certificate for this \npaper is available at https​://doi.org/10.5281/zenod​o.40038​48. CODECHECK is an \nopen-science initiative to facilitate sharing of computer programs and results pre-\nsented in scientific publications (see https​://codec​heck.org.uk/) Funding  Open Access funding provided by Norwegian School of Economics. Funding  Open Access funding provided by Norwegian School of Economics. Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, \nwhich permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as \nyou give appropriate credit to the original author(s) and the source, provide a link to the Creative Com-\nmons licence, and indicate if changes were made. The images or other third party material in this article \nare included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the \nmaterial. 5  \u0007Outlook If material is not included in the article’s Creative Commons licence and your intended use is \nnot permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission \ndirectly from the copyright holder. To view a copy of this licence, visit http://creat​iveco​mmons​.org/licen​\nses/by/4.0/. nding  Open Access funding provided by Norwegian School of Economics. References https\nCRAN.R-proje​ct.org/packa​ge=rgeos​, R package version 0.5-3 Bivand R, Pebesma E, Gomez-Rubio V (2008) Applied spatial data analysis with R. Springer, New Y Bivand R, Pebesma E, Gomez-Rubio V (2008) Applied spatial data analysis with R. Springer, New Yor\nBivand R, Pebesma E, Gomez-Rubio V (2013) Applied spatial data analysis with R, 2nd edn. 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https://openalex.org/W2338185363
https://publikationen.bibliothek.kit.edu/1000055744/4284342
English
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Infrared Spectroscopy of Bilberry Extract Water-in-Oil Emulsions: Sensing the Water-Oil Interface
Biosensors
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Infrared Spectroscopy of Bilberry Extract Water-in-Oil Emulsions: Sensing the Water-Oil Interface 2 Erlangen Graduate School in Advanced Optical Technologies, University of Erlangen-Nuremberg, Erlangen 91052, Germany 3 School of Engineering, University of Aberdeen, Aberdeen AB24 3UE, UK 4 Section I: Food Process Engine...
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https://media.fupress.com/files/pdf/24/7257/19362
Italian
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Introduzione
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Mauro Lombardi, University of Florence, Italy, mauro.lombardi@unifi.it, 0000-0002-3234-7039 FUP Best Practice in Scholarly Publishing (DOI 10.36253/fup_best_practice) Mauro Lombardi, Introduzione, pp. 9-13, © 2021 Author(s), CC BY 4.0 International, DOI 10.36253/978-88- 5518-310-9.02, in Mauro Lombardi, Transizione eco...
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https://europepmc.org/articles/pmc3790907?pdf=render
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Production of schizophyllan from distiller’s dried grains with solubles by diverse strains of Schizophyllum commune
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© 2013 Sutivisedsak et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ...
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https://www.repository.cam.ac.uk/bitstreams/78f182a1-31c3-4775-ae56-88cddbcf7b2a/download
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A chiral phosphazane reagent strategy for the determination of enantiomeric excess of amines
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aYusuf Hamied Department of Chemistry, Cambridge University, Lenseld Road, Cambridge, CB2 1EW, UK. E-mail: dsw1000@cam.ac.uk bThe Faraday Institution Quad One, Harwell Science and Innovation Campus, Didcot, UK † Electronic supplementary information (ESI) available: synthetic procedures and analytical data, NMR and X-r...
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https://discovery.ucl.ac.uk/id/eprint/1378611/1/1378611.pdf
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A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
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ABSTRACT Motivation: The Illumina Infinium 450 k DNA Methylation Beadchip is a prime candidate technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterized by widely differ- ent DNA methylation distributions ...
https://openalex.org/W1998627129
https://www.nature.com/articles/ncomms7539.pdf
English
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Aqueous proton transfer across single-layer graphene
Nature communications
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ARTICLE Received 5 Nov 2014 | Accepted 6 Feb 2015 | Published 17 Mar 2015 & 2015 Macmillan Publishers Limited. All rights reserved. Aqueous proton transfer across single-layer graphene B r n s charge density, in the duration of the jumps or in the rates of the jumps when single-layer graphene is present. These findings ...
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https://www.scienceopen.com/document_file/c88897fc-480b-4467-a0a8-f921dd840c2c/ScienceOpen/420_Goldman.pdf
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Poetry Inspired, Physics Driven, Experimental Animation
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DOI: http://dx.doi.org/10.14236/ewic/EVA2017.83 DOI: http://dx.doi.org/10.14236/ewic/EVA2017.83 1. INTRODUCTION work. For example, our visualisation “Sky Pacers” was partially inspired by an ancient Chinese star catalogue in the form of a poem specifying the names of stars, “The Song of the Sky Pacers”. The ancient...
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https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-024-03319-3
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The management of uterine tumor resembling an ovarian sex cord tumor (UTROSCT): case series and literature review
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Open Access Open Access Abstract Aims  To present a case series of 11 rare uterine tumors resembling ovarian sex cord tumors (UTROSCTs), and review the literature on this topic to offer up-to-date treatment management for UTROSCTs. Method  Eight cases from Fujian Cancer Hospital between January 2017 and May 2023 and t...
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http://ejournal2.litbang.kemkes.go.id/index.php/hsji/article/download/3150/1705
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Risk factors associated with Dengue incidence in Bandung, Indonesia: a household based case-control study
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Risk factors associated with Dengue incidence in Bandung, Indonesia Risk factors associated with Dengue incidence in Bandung, Indonesia 45 Vol. 11, No. 1, June 2020 Unit of Health Research and Development of Pangandaran District, West Java Province, Ministry of Health of Republic of Indonesia Unit of Health Research a...
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https://annals-csis.org/proceedings/2020/drp/pdf/197.pdf
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Feasibility of computerized adaptive testing evaluated by Monte-Carlo and post-hoc simulations
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Proceedings of the Federated Conference on Proceedings of the Federated Conference on Computer Science and Information Systems pp. 359–367 DOI: 10.15439/2020F197 ISSN 2300-5963 ACSIS, Vol. 21 Feasibility of computerized adaptive testing evaluated by Monte-Carlo and post-hoc simulations Patrícia Martinková Institute of ...
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http://www.nomos-elibrary.de/10.5771/1611-5821-2012-5-52.pdf
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Analyse der Mitgliederentwicklung sowie weiterer Kennzahlen der bundesunmittelbaren Krankenkassen ohne und mit Zusatzbeitrag bzw. Prämie
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THEMA THEMA 1 Dieser Beitrag gibt die persönlichen Auffas- sungen der Verfasser wieder. Maximilian GaSSner, Frank Otto, Eva Ludwig Dr. Maximilian Gaßner ist Präsident des Bundesversiche- rungsamts (BVA) in Bonn Dr. Maximilian Gaßner ist Präsident des Bundesversiche- rungsamts (BVA) in Bonn Frank Otto ist Referatsle...
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https://europepmc.org/articles/pmc3125199?pdf=render
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A novel method to prepare L-Arabinose from xylose mother liquor by yeast-mediated biopurification
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* Correspondence: mzxyjiang@163.com; zxdeng@sjtu.edu.cn 1Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800# Dongchuan Road, Shanghai, China 2School of Chemistry and Ecology Engineering, Guangxi University for Nationalities, Nanning, China Full list of a...
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https://pure.mpg.de/pubman/item/item_2376926_4/component/file_2394932/journal.pbio.1002563.PDF
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Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release
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OPEN ACCESS * stephan.sigrist@fu-berlin.de Citation: Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, et al. (2016) Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release. PLoS Biol 14(9): e1002563. doi:10.1371/journal.pbio.1002563...
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https://pure.mpg.de/pubman/item/item_2525905_1/component/file_2525904/JCI94509.pdf
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STAT5BN642H is a driver mutation for T cell neoplasia
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Downloaded from http://www.jci.org on January 18, 2018. https://doi.org/10.1172/JCI94509 Downloaded from http://www.jci.org on January 18, 2018. https://doi.org/10.1172/JCI94509 Downloaded from http://www.jci.org on January 18, 2018. https://doi.org/10.1172/JCI94509 R E S E A R C H A R T I C L E Conflict of interest...
https://openalex.org/W4388265398
https://etrr.springeropen.com/counter/pdf/10.1186/s12544-023-00606-0
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Modelling public attitude towards drone delivery in Germany
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© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to ...
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https://zenodo.org/records/3818215/files/16B8509%20Multiple%20case%20studies.pdf
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16B8509 Multiple Case Studies
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BB 4312 ORGANIZATIONAL DEVELOPMENT AND CHANGE INDIVIDUAL REPORT “Multiple Case Studies” Prepared By: Nurul Azzimatul Adawiyah Hj Omar Student ID: 16B8509 Prepared For: Pg Dr Siti Rozaidah Pg Hj Idris Submission Date: 5 May 2020 (Tuesday) Table of Contents Abstract .............................................
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https://zenodo.org/record/6414976/files/050422en.pdf
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PUBLIC COMMUNICATION ON SOCIAL MEDIA: CONNECTING GOVERNMENTS AND CITIZENS ONLINE
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PUBLIC COMMUNICATION ON SOCIAL MEDIA: CONNECTING GOVERNMENTS AND CITIZENS ONLINE Author: Priscila Minussii PUBLIC COMMUNICATION ON SOCIAL MEDIA: CONNECTING GOVERNMENTS AND CITIZENS ONLINE Author: Priscila Minussii PUBLIC COMMUNICATION ON SOCIAL MEDIA: CONNECTING GOVERNMENTS AND CITIZENS ONLINE Author: Priscila...
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Commentary: From ‘sense of number’ to ‘sense of magnitude’ – The role of continuous magnitudes in numerical cognition
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GENERAL COMMENTARY published: 04 January 2017 doi: 10.3389/fpsyg.2016.02032 Peter Kramer* and Paola Bressan Keywords: sense of number, sense of magnitude, numerosity estimation, occupancy, statistical learning A commentary on From ‘sense of number’ to ‘sense of magnitude’ – The role of continuous magnitudes in numerica...
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https://researchonline.lshtm.ac.uk/id/eprint/2130250/1/pone.0119271.pdf
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Pertussis Post-Exposure Prophylaxis among Household Contacts: A Cost-Utility Analysis
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RESEARCH ARTICLE Nisha Thampi1,2*, Ipek Gurol-Urganci3, Natasha S. Crowcroft4,5, Beate Sander5,6,7,8 1 Division of Infectious Diseases, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada, 2 University of Ottawa, Ottawa, ON, Canada, 3 Department of Health Services Research and Policy, London School of Hygiene an...
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http://real.mtak.hu/174341/1/Berenyi_etal_2023_published.pdf
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Comprehensive analysis of the ionospheric response to the largest geomagnetic storms from solar cycle 24 over Europe
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TYPE Original Research PUBLISHED 24 April 2023 DOI 10.3389/fspas.2023.1092850 TYPE Original Research PUBLISHED 24 April 2023 DOI 10.3389/fspas.2023.1092850 TYPE Original Research PUBLISHED 24 April 2023 DOI 10.3389/fspas.2023.1092850 geomagnetic storms, space weather, ionosphere, ionospheric storm, midlatitude ionosphe...
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Identification of ATP binding residues of a protein from its primary sequence
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BioMed Central BioMed Central Identification of ATP binding residues of a protein from its primary sequence Address: Institute of Microbial Technology, Chandigarh, India Email: Jagat S Chauhan - jagat@imtech.res.in; Nitish K Mishra - nitish@imtech.res.in; Gajendra PS Raghava* - raghava@imtech.res.in * Corresponding au...
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https://link.springer.com/content/pdf/10.1007%2Fs00384-018-3108-5.pdf
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Meta-analysis of the prognostic value of CpG island methylator phenotype in rectal cancer
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International Journal of Colorectal Disease (2018) 33:995–1000 https://doi.org/10.1007/s00384-018-3108-5 International Journal of Colorectal Disease (2018) 33:995–1000 https://doi.org/10.1007/s00384-018-3108-5 REVIEW REVIEW REVIEW 1 ABMU Singleton Hospital, Sketty Lane, Swansea, Wales SA2 8QA, UK Abstract bst act Purpo...