id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
244,688,673
O=C(O)C[C@@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
COC(=O)c1cccc(N)n1
COC(=O)c1cccc(Nc2nc(NCc3ccnc(C(N)=O)c3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(C(F)(F)F)cc3)n2)n1
BRD4
0
139,655,644
O=C(Nc1c(C(=O)O)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(C)(CN)C1CC1
Nc1nc(F)nc2nc[nH]c12
COC(C)(CNc1nc(Nc2c(C(=O)O)cccc2C(=O)N[Dy])nc(Nc2nc(F)nc3nc[nH]c23)n1)C1CC1
HSA
0
140,383,927
O=C(Nc1c(C(=O)O)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(O)cn1
Nc1ncnc2[nH]ncc12
O=C(O)c1cccc(C(=O)N[Dy])c1Nc1nc(Nc2ccc(O)cn2)nc(Nc2ncnc3[nH]ncc23)n1
HSA
0
266,637,220
O=C(O)C[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCc1ccc2[nH]ccc2c1
Nc1cn2nc(Cl)ccc2n1
O=C(C[C@H](Cc1ccc(C(F)(F)F)cc1)Nc1nc(NCc2ccc3[nH]ccc3c2)nc(Nc2cn3nc(Cl)ccc3n2)n1)N[Dy]
HSA
0
88,011,039
O=C(N[C@@H](C/C=C/c1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)nc(Cl)n1
Nc1cc(C2CC2)[nH]n1
O=C(N[Dy])[C@H](C/C=C/c1ccccc1)Nc1nc(Nc2cc(C3CC3)[nH]n2)nc(Nc2cc(Cl)nc(Cl)n2)n1
BRD4
0
190,309,716
O=C(Nc1ccc(C(=O)O)cc1Cl)OCC1c2ccccc2-c2ccccc21
NCC1(N2CCOCC2)CC1
Nc1ccc(N2CCOCC2)c(F)c1
O=C(N[Dy])c1ccc(Nc2nc(NCC3(N4CCOCC4)CC3)nc(Nc3ccc(N4CCOCC4)c(F)c3)n2)c(Cl)c1
BRD4
0
174,289,030
O=C(Nc1cc(F)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ncc([N+](=O)[O-])s1
CCn1nccc1CN
CCn1nccc1CNc1nc(Nc2ncc([N+](=O)[O-])s2)nc(Nc2cc(F)c(F)cc2C(=O)N[Dy])n1
HSA
0
93,874,149
O=C(N[C@@H](Cc1ccc(C(F)(F)F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1O
NCC1(c2ccc3c(c2)OCO3)CCCCC1
COC(=O)c1ccc(Nc2nc(NCC3(c4ccc5c(c4)OCO5)CCCCC3)nc(N[C@@H](Cc3ccc(C(F)(F)F)cc3)C(=O)N[Dy])n2)cc1O
BRD4
0
62,727,941
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Cl.NCCc1cc(Br)c(Br)s1
NCc1cnc(-c2ccccc2)s1
Cn1cc(C[C@@H](Nc2nc(NCCc3cc(Br)c(Br)s3)nc(NCc3cnc(-c4ccccc4)s3)n2)C(=O)N[Dy])c2ccccc21
sEH
0
115,254,304
O=C(N[C@H](C(=O)O)c1ccsc1)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)c(F)cc1[N+](=O)[O-]
CN1CCN(c2ccc(N)cc2F)CC1
CN1CCN(c2ccc(Nc3nc(Nc4cc(F)c(F)cc4[N+](=O)[O-])nc(N[C@H](C(=O)N[Dy])c4ccsc4)n3)cc2F)CC1
HSA
0
453,586
C#CC[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1sc(CCN)nc1-c1ccccc1.Cl.Cl
CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1
C#CC[C@@H](CC(=O)N[Dy])Nc1nc(NCCc2nc(-c3ccccc3)c(C)s2)nc(Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)n1
HSA
0
109,635,565
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1ncc2cc(N)ccc21
Nc1cccc(OCc2ccccc2)c1
Cn1ncc2cc(Nc3nc(Nc4cccc(OCc5ccccc5)c4)nc(N[C@@H](Cc4cscn4)C(=O)N[Dy])n3)ccc21
HSA
0
284,533,207
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1F
Nc1ccc(C(=O)N2CCOCC2)cc1
COC(=O)c1cc(Nc2nc(Nc3ccc(C(=O)N4CCOCC4)cc3)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)ccc1F
HSA
0
108,553,976
O=C(N[C@@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1cc(F)ccc1N
Cl.NCc1cnc(Cl)s1
N#Cc1cc(F)ccc1Nc1nc(NCc2cnc(Cl)s2)nc(N[C@@H](Cc2csc3ccccc23)C(=O)N[Dy])n1
sEH
0
971,212
C#CC[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cnccc2c1
COc1ccc(N)nc1
C#CC[C@@H](CC(=O)N[Dy])Nc1nc(Nc2ccc3cnccc3c2)nc(Nc2ccc(OC)cn2)n1
HSA
0
76,306,764
O=C(NC1(C(=O)O)CCC1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
Cl.NCc1cscc1C(F)(F)F
CC(C)(CCC#N)CNc1nc(NCc2cscc2C(F)(F)F)nc(NC2(C(=O)N[Dy])CCC2)n1
BRD4
0
61,866,823
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)ccc1F
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1ccccc1[C@@H](CC(=O)N[Dy])Nc1nc(NCc2ccc(O)c3ncccc23)nc(Nc2cc(Cl)ccc2F)n1
HSA
0
246,604,674
O=C(O)C[C@@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(-c2cc(C(F)(F)F)nc(OCCN)n2)cc1
Cl.Nc1ncns1
Cc1ccc(-c2cc(C(F)(F)F)nc(OCCNc3nc(Nc4ncns4)nc(N[C@@H](CC(=O)N[Dy])Cc4ccc(Cl)cc4)n3)n2)cc1
BRD4
0
26,959,633
COC(=O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cccc(N2CCOCC2)c1
Cc1nc(Cl)c(N)c(Cl)n1
COC(=O)CC(Nc1nc(NCc2cccc(N3CCOCC3)c2)nc(Nc2c(Cl)nc(C)nc2Cl)n1)C(=O)N[Dy]
HSA
0
191,155,530
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(-n2cncn2)cc1
Cl.NCc1nc2cc(F)ccc2o1
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(-n4cncn4)cc3)nc(NCc3nc4cc(F)ccc4o3)n2)c(F)c1
BRD4
0
19,558,834
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1nc(C2CC2)cs1
NCc1nc2c(s1)CCCC2
CC(OC(C)(C)C)C(Nc1nc(NCc2nc3c(s2)CCCC3)nc(Nc2nc(C3CC3)cs2)n1)C(=O)N[Dy]
HSA
0
22,842,669
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
Nc1ncc(Cl)cc1F
Cl.NCCC1CN(c2ncnc3[nH]ncc23)c2ccccc21
CCOc1cc(Nc2nc(NCCC3CN(c4ncnc5[nH]ncc45)c4ccccc43)nc(Nc3ncc(Cl)cc3F)n2)c(Cl)cc1C(=O)N[Dy]
BRD4
0
187,035,620
O=C(Nc1ccc(C(=O)O)c([N+](=O)[O-])c1)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC=CC1
Cn1ncc(C#N)c1N
Cn1ncc(C#N)c1Nc1nc(NCC2(CO)CC=CC2)nc(Nc2ccc(C(=O)N[Dy])c([N+](=O)[O-])c2)n1
sEH
0
232,358,432
O=C(O)C1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
COc1ncc(N)cn1
Cn1ncc(C#N)c1N
COc1ncc(Nc2nc(Nc3c(C#N)cnn3C)nc(N3CCCC3C(=O)N[Dy])n2)cn1
sEH
0
25,150,231
CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC1CCCCC1)C(=O)O
CCC(CN)Oc1ccccc1C.Cl
Cc1ccc(F)c(N)c1
CCC(CNc1nc(Nc2cc(C)ccc2F)nc(N(C)[C@@H](CC2CCCCC2)C(=O)N[Dy])n1)Oc1ccccc1C
HSA
0
228,703,746
O=C(Nc1nc2ncc(CNc3ccc(C(=O)O)cc3)nc2c(=O)[nH]1)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1[N+](=O)[O-]
NCC(O)COc1cccc(Cl)c1Cl
O=C(N[Dy])c1ccc(NCc2cnc3nc(Nc4nc(NCC(O)COc5cccc(Cl)c5Cl)nc(Nc5cccnc5[N+](=O)[O-])n4)[nH]c(=O)c3n2)cc1
BRD4
0
274,004,763
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Cl.NCC(F)(F)C1CC1
Nc1ncnc(Cl)c1Cl
O=C(C[C@H](Nc1nc(NCC(F)(F)C2CC2)nc(Nc2ncnc(Cl)c2Cl)n1)c1ccc(F)cc1)N[Dy]
BRD4
0
195,352,106
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Cc1c(N)cccc1Br
Nc1nnc(S)s1
Cc1c(Br)cccc1Nc1nc(Nc2ccc(C(=O)N[Dy])nc2)nc(Nc2nnc(S)s2)n1
sEH
0
182,537,645
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCCCCN1C(=O)c2ccccc2C1=O
NCc1cnn(Cc2ccccc2)c1
O=C(O)c1cc(Nc2nc(NCCCCN3C(=O)c4ccccc4C3=O)nc(NCc3cnn(Cc4ccccc4)c3)n2)ccc1C(=O)N[Dy]
sEH
0
281,905,899
O=C(O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
NCc1ccccn1
Cl.Cl.NCC1(c2ccncc2)CC1
O=C(N[Dy])[C@@H]1CCCN1C(=O)[C@@H]1CCCN1c1nc(NCc2ccccn2)nc(NCC2(c3ccncc3)CC2)n1
BRD4
0
165,539,249
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1nc(-c2ccc(F)cc2)cs1
NCc1c(Br)cncc1Br
O=C(N[Dy])c1ccc(C(=O)O)c(Nc2nc(NCc3c(Br)cncc3Br)nc(Nc3nc(-c4ccc(F)cc4)cs3)n2)c1
sEH
0
181,307,334
O=C(Nc1ccc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1sc(N)c(C#N)c1C
Cl.NCC1CCCC2(CCC2)C1O
Cc1sc(Nc2nc(NCC3CCCC4(CCC4)C3O)nc(Nc3ccc(Br)cc3C(=O)N[Dy])n2)c(C#N)c1C
BRD4
0
207,970,415
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cn[nH]c2c1
Nc1nc2c(s1)CN(C(=O)OCc1ccccc1)CC2
O=C(N[Dy])c1cccc(-c2cccc(Nc3nc(Nc4ccc5cn[nH]c5c4)nc(Nc4nc5c(s4)CN(C(=O)OCc4ccccc4)CC5)n3)c2O)c1
sEH
0
10,535,097
C=CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC1(C2CC2)CCCO1
NCC1(c2ccc(Cl)cc2Cl)CCCC1
C=CC[C@H](Nc1nc(NCC2(c3ccc(Cl)cc3Cl)CCCC2)nc(NCC2(C3CC3)CCCO2)n1)C(=O)N[Dy]
BRD4
0
110,763,471
O=C(N[C@@H]1CC[C@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC2C=CC1C2
Cl.Cl.NCC(=O)Nc1nccs1
O=C(CNc1nc(NCC2(CO)CC3C=CC2C3)nc(N[C@@H]2CC[C@H](C(=O)N[Dy])C2)n1)Nc1nccs1
BRD4
0
165,753,567
O=C(Nc1cc(C(=O)O)ccc1C(F)(F)F)OCC1c2ccccc2-c2ccccc21
CN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1
COC(=O)c1cc(N)ccc1Cl
COC(=O)c1cc(Nc2nc(Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)nc(Nc3cc(C(=O)N[Dy])ccc3C(F)(F)F)n2)ccc1Cl
BRD4
0
276,481,696
O=C(O)C[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(Br)ccn1
Cc1nc(Cl)c(N)c(Cl)n1
Cc1nc(Cl)c(Nc2nc(Nc3cc(Br)ccn3)nc(N3CCC[C@@H]3CC(=O)N[Dy])n2)c(Cl)n1
HSA
0
123,267,625
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CNC(=O)C(O)CN.Cl
Cc1ccc(CN)c(Cl)n1
CNC(=O)C(O)CNc1nc(NCc2ccc(C)nc2Cl)nc(N[C@H](Cc2ccc(F)c(F)c2)C(=O)N[Dy])n1
HSA
0
144,807,448
O=C(Nc1c(Cl)c(Cl)nc(C(=O)O)c1Cl)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1Cl
Nc1nc2cccc(Br)n2n1
O=C(N[Dy])c1nc(Cl)c(Cl)c(Nc2nc(Nc3nc4cccc(Br)n4n3)nc(Nc3cccnc3Cl)n2)c1Cl
HSA
0
111,220,964
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
CCN1CCN(Cc2ccc(N)nc2)CC1
CC(CN)c1c(Cl)cccc1Cl
CCN1CCN(Cc2ccc(Nc3nc(NCC(C)c4c(Cl)cccc4Cl)nc(N[C@H](C(=O)N[Dy])C4CC4)n3)nc2)CC1
sEH
0
139,612,178
O=C(Nc1c(C(=O)O)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CNC(=O)C(O)CN.Cl
Cc1nc(N)ccc1Cl
CNC(=O)C(O)CNc1nc(Nc2ccc(Cl)c(C)n2)nc(Nc2c(C(=O)O)cccc2C(=O)N[Dy])n1
sEH
0
246,448,335
O=C(O)C[C@@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1c(F)cc(N)cc1F
Cl.Cl.NCC#Cc1cccnc1
COc1c(F)cc(Nc2nc(NCC#Cc3cccnc3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(Cl)cc3)n2)cc1F
BRD4
0
210,959,110
O=C(Nc1cccc(C(=O)O)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1ccc2cc(N)ccc21
Cn1cc(-c2ccccc2CN)cn1
Cn1cc(-c2ccccc2CNc2nc(Nc3ccc4c(ccn4C)c3)nc(Nc3cccc(C(=O)N[Dy])c3C(=O)O)n2)cn1
HSA
0
182,536,527
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.NCCCCN1C(=O)c2ccccc2C1=O
CC(C)NC(=O)NCCN.Cl.Cl
CC(C)NC(=O)NCCNc1nc(NCCCCN2C(=O)c3ccccc3C2=O)nc(Nc2ccc(C(=O)N[Dy])c(C(=O)O)c2)n1
BRD4
0
72,676,639
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1SCCS1
Cl.NCC1CNC(=O)C1
O=C1CC(CNc2nc(NCCC3SCCS3)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)CN1
HSA
0
155,949,875
O=C(Nc1cc(-n2cccn2)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1CCN(Cc2cccc(N)c2)CC1
Nc1nc2ccccc2o1
CN1CCN(Cc2cccc(Nc3nc(Nc4nc5ccccc5o4)nc(Nc4cc(-n5cccn5)ccc4C(=O)N[Dy])n3)c2)CC1
sEH
0
217,365,447
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1C=CCC1
Nc1cc[nH]c(=O)c1
O=C(N[Dy])c1ncccc1Nc1nc(NCC2C=CCC2)nc(Nc2cc[nH]c(=O)c2)n1
BRD4
0
70,514,645
N#Cc1cccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)c1
NCCc1coc2ccccc12
COC(=O)c1cc(OC)c(OC)cc1N
COC(=O)c1cc(OC)c(OC)cc1Nc1nc(NCCc2coc3ccccc23)nc(N[C@@H](CC(=O)N[Dy])Cc2cccc(C#N)c2)n1
sEH
0
53,980,238
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cl.NCCCN1C(=O)CCC1=O
CN(Cc1ccco1)Cc1ccccc1CN
Cc1ccc(C(=O)N[Dy])c(Nc2nc(NCCCN3C(=O)CCC3=O)nc(NCc3ccccc3CN(C)Cc3ccco3)n2)c1C
sEH
0
92,698,377
O=C(N[C@@H](Cc1ccc(Br)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCN1C(=O)C[C@H](CN)[C@H]1c1ccncc1
Nc1ccncc1[N+](=O)[O-]
CCN1C(=O)C[C@H](CNc2nc(Nc3ccncc3[N+](=O)[O-])nc(N[C@@H](Cc3ccc(Br)cc3)C(=O)N[Dy])n2)[C@H]1c1ccncc1
BRD4
0
4,267,318
C#CC[C@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ocnc12
Nc1cc(=O)[nH]c(=S)[nH]1
C#CC[C@H](CC(=O)N[Dy])Nc1nc(Nc2cc(=O)[nH]c(=S)[nH]2)nc(Nc2cccc3ocnc23)n1
HSA
0
267,436,214
O=C(O)C[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ncc[nH]1
NCc1ccsc1
O=C(C[C@H](Cc1ccc(Cl)c(Cl)c1)Nc1nc(NCc2ccsc2)nc(NCc2ncc[nH]2)n1)N[Dy]
sEH
0
24,268,671
CCc1cccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C(=O)O
COc1ncc(N)cn1
Nc1cc(Cl)c(O)c(Cl)c1
CCc1cccc(Nc2nc(Nc3cnc(OC)nc3)nc(Nc3cc(Cl)c(O)c(Cl)c3)n2)c1C(=O)N[Dy]
BRD4
0
197,181,461
O=C(Nc1ccc(C(F)(F)F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1F
Nc1nccc(=O)[nH]1
O=C(N[Dy])c1cc(C(F)(F)F)ccc1Nc1nc(Nc2nccc(=O)[nH]2)nc(Nc2ncccc2F)n1
sEH
0
155,697,220
O=C(Nc1c(OC(F)(F)F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ncccc12
Cc1nc(Cl)c(N)c(Cl)n1
Cc1nc(Cl)c(Nc2nc(Nc3c(OC(F)(F)F)cccc3C(=O)N[Dy])nc(Nc3cccc4ncccc34)n2)c(Cl)n1
HSA
0
177,284,553
O=C(Nc1cc(I)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NC[C@@H]1CCC(=O)N1
NCCc1ccc(N2CCOCC2)c(F)c1
O=C1CC[C@@H](CNc2nc(NCCc3ccc(N4CCOCC4)c(F)c3)nc(Nc3cc(I)ccc3C(=O)N[Dy])n2)N1
BRD4
0
72,138,845
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1c(F)cc(N)cc1F
Nc1ccc(-c2ccccc2)cn1
COc1c(F)cc(Nc2nc(Nc3ccc(-c4ccccc4)cn3)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)cc1F
sEH
0
194,972,763
O=C(Nc1ccc(C(=O)O)cn1)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ncc1Cl
CCSc1ccc(CN)cc1
CCSc1ccc(CNc2nc(Nc3ccc(C(=O)N[Dy])cn3)nc(Nc3nc(Cl)ncc3Cl)n2)cc1
BRD4
0
154,580,910
O=C(Nc1c(I)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2cn[nH]c2c1
NCCc1nccc(C2CC2)n1
O=C(N[Dy])c1cccc(I)c1Nc1nc(NCCc2nccc(C3CC3)n2)nc(Nc2ccc3cn[nH]c3c2)n1
BRD4
0
45,980,098
Cc1c(Br)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
COCCNC(=O)CN.Cl
Nc1ncc(-c2ccccc2)s1
COCCNC(=O)CNc1nc(Nc2ncc(-c3ccccc3)s2)nc(Nc2c(C(=O)N[Dy])ccc(Br)c2C)n1
HSA
0
170,107,655
O=C(Nc1cc(Cl)nc(C(=O)O)c1Cl)OCC1c2ccccc2-c2ccccc21
CN1CCN(C(=O)CN)CC1
CCOC(=O)c1sc(N)nc1C
CCOC(=O)c1sc(Nc2nc(NCC(=O)N3CCN(C)CC3)nc(Nc3cc(Cl)nc(C(=O)N[Dy])c3Cl)n2)nc1C
sEH
0
258,062,073
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Cl)cc1
Nc1ccc2[nH]ncc2c1
Cc1ccc(-c2cc(C(F)(F)F)nc(OCCN)n2)cc1
Cc1ccc(-c2cc(C(F)(F)F)nc(OCCNc3nc(Nc4ccc5[nH]ncc5c4)nc(N[C@H](CC(=O)N[Dy])c4ccc(Cl)cc4)n3)n2)cc1
BRD4
0
121,723,933
O=C(N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1c[nH]c2ccccc12
Cl.NCc1ccc(-c2c[nH]c(=O)[nH]c2=O)cc1
O=C(N[Dy])[C@@H](Cc1ccc(Cl)c(Cl)c1)Nc1nc(NCc2ccc(-c3c[nH]c(=O)[nH]c3=O)cc2)nc(NCc2c[nH]c3ccccc23)n1
HSA
0
282,326,602
O=C(O)[C@@H]1CSCN1C(=O)OCC1c2ccccc2-c2ccccc21
CN1CCN(CCN)CC1
CSCc1nnc(CN)[nH]1.Cl
CSCc1nnc(CNc2nc(NCCN3CCN(C)CC3)nc(N3CSC[C@H]3C(=O)N[Dy])n2)[nH]1
HSA
0
25,949,728
CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC1CCCCC1)C(=O)O
Nc1ccc(Cl)c(C(F)(F)F)c1
Cl.NCc1nc2cc(F)ccc2o1
CN(c1nc(NCc2nc3cc(F)ccc3o2)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1)[C@@H](CC1CCCCC1)C(=O)N[Dy]
HSA
0
175,094,612
O=C(Nc1cc(F)cc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCN1CCC2(C1)OCCO2
Nc1ccnc(Cl)c1
O=C(N[Dy])c1c(F)cc(F)cc1Nc1nc(NCCN2CCC3(C2)OCCO3)nc(Nc2ccnc(Cl)c2)n1
sEH
0
269,920,074
O=C(O)C[C@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCc1ccccn1
Cc1cc(N)on1
Cc1cc(Nc2nc(NCc3ccccn3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(F)cc3)n2)on1
BRD4
0
61,012,557
Cc1ccccc1[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
C#CCOc1cccc(CN)c1.Cl
Nc1nc(=O)[nH]cc1Br
C#CCOc1cccc(CNc2nc(Nc3nc(=O)[nH]cc3Br)nc(N[C@H](CC(=O)N[Dy])c3ccccc3C)n2)c1
BRD4
0
168,601,202
O=C(Nc1cc(Cl)cc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
NCc1ccccn1
Nc1cccc(OC(F)F)c1
O=C(N[Dy])c1cc(Cl)cc(Nc2nc(NCc3ccccn3)nc(Nc3cccc(OC(F)F)c3)n2)c1
sEH
0
57,713,271
Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1ncc(F)cn1
Nc1nccc(-c2cccnc2)n1
Cc1ccc(C[C@H](Nc2nc(Nc3ncc(F)cn3)nc(Nc3nccc(-c4cccnc4)n3)n2)C(=O)N[Dy])cc1
BRD4
0
93,319,499
O=C(N[C@@H](Cc1ccc(Br)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1ncc(N)cc1C(F)(F)F
NCCOc1cccnc1
N#Cc1ncc(Nc2nc(NCCOc3cccnc3)nc(N[C@@H](Cc3ccc(Br)cc3)C(=O)N[Dy])n2)cc1C(F)(F)F
sEH
0
254,284,228
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ncc(N)cc1Br
NCC(c1cccs1)N1CCOCC1
Cc1ncc(Nc2nc(NCC(c3cccs3)N3CCOCC3)nc(N[C@@H](CC(=O)N[Dy])Cc3cccs3)n2)cc1Br
HSA
0
149,908,508
O=C(Nc1c(F)cc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1cc(C)c(CN)c(=O)[nH]1.Cl
Cc1cc(C)c(CNc2nc(NCc3cnc4n3CCOC4)nc(Nc3c(F)cc(C(=O)N[Dy])cc3F)n2)c(=O)[nH]1
sEH
0
78,228,095
O=C(NC1(C(=O)O)CCCC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)ccn1
Cc1cc(CN)cc(Cl)n1.Cl.Cl
Cc1cc(CNc2nc(Nc3cc(F)ccn3)nc(NC3(C(=O)N[Dy])CCCC3)n2)cc(Cl)n1
sEH
0
102,782,470
O=C(N[C@@H](Cc1ccccc1F)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ncc1[N+](=O)[O-]
Cl.Cn1cc(N)ccc1=O
Cc1cc(Nc2nc(Nc3ccc(=O)n(C)c3)nc(N[C@@H](Cc3ccccc3F)C(=O)N[Dy])n2)ncc1[N+](=O)[O-]
HSA
0
217,616,620
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1ccc2[nH]ccc2c1
Nc1nc2c(Br)cccc2s1
O=C(N[Dy])c1ncccc1Nc1nc(NCc2ccc3[nH]ccc3c2)nc(Nc2nc3c(Br)cccc3s2)n1
HSA
0
12,253,582
CC(C)(C)OC(=O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(N)cc1[N+](=O)[O-]
Nc1nc(Cl)c2cn[nH]c2n1
COc1ccc(Nc2nc(Nc3nc(Cl)c4cn[nH]c4n3)nc(NC(CC(=O)OC(C)(C)C)C(=O)N[Dy])n2)cc1[N+](=O)[O-]
HSA
0
191,909,539
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
CN1CCN(c2ccc(N)cc2F)CC1
COc1cncc(N)n1
COc1cncc(Nc2nc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc(Nc3ccc(C(=O)N[Dy])cc3O)n2)n1
HSA
0
132,101,625
O=C(N[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cccc(F)c1CN
Cl.NCCNC(=O)c1ccn[nH]1
COc1cccc(F)c1CNc1nc(NCCNC(=O)c2ccn[nH]2)nc(N[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
BRD4
0
114,908,364
O=C(N[C@H](C(=O)O)c1ccsc1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1nccn1-c1ccccc1
CN(C)c1cccnc1CN
CN(C)c1cccnc1CNc1nc(NCc2nccn2-c2ccccc2)nc(N[C@H](C(=O)N[Dy])c2ccsc2)n1
BRD4
0
243,361,431
O=C(O)C[C@@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccnc(Cl)c1N
Cc1ccc(CN)n1C
Cc1ccnc(Cl)c1Nc1nc(NCc2ccc(C)n2C)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(Br)cc2)n1
BRD4
0
262,340,007
O=C(O)C[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)cc(F)c1[N+](=O)[O-]
CS(=O)(=O)Nc1ccc(-c2csc(N)n2)cc1
CS(=O)(=O)Nc1ccc(-c2csc(Nc3nc(Nc4cc(F)cc(F)c4[N+](=O)[O-])nc(N4CCC[C@H]4CC(=O)N[Dy])n3)n2)cc1
BRD4
0
16,928,286
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCCC1CC2(CCC2)CO1
Cc1nc(CN)ccc1C(C)O.Cl.Cl
Cc1nc(CNc2nc(NCCC3CC4(CCC4)CO3)nc(NC(COC(C)(C)C)C(=O)N[Dy])n2)ccc1C(C)O
BRD4
0
30,966,049
COc1cc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)cn1
Cl.Cl.NCC1(N2CCOCC2)CCOCC1
COC(=O)c1sccc1N
COC(=O)c1sccc1Nc1nc(NCC2(N3CCOCC3)CCOCC2)nc(Nc2cnc(OC)cc2C(=O)N[Dy])n1
HSA
0
41,273,821
COc1nccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)OCO2
Nc1cccc(N2CCOCC2)c1
COc1nccc(C(=O)N[Dy])c1Nc1nc(Nc2cccc(N3CCOCC3)c2)nc(Nc2ccc3c(c2)OCO3)n1
HSA
0
42,491,013
CSc1ncc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)n1
C#Cc1ccc(N)cc1
Cl.NCc1noc2ccc(F)cc12
C#Cc1ccc(Nc2nc(NCc3noc4ccc(F)cc34)nc(Nc3cnc(SC)nc3C(=O)N[Dy])n2)cc1
BRD4
0
248,135,163
O=C(O)C[C@@H](Cc1ccc(Cl)cc1Cl)NC(=O)OCC1c2ccccc2-c2ccccc21
NCc1cccnc1N1CCC(C(N)=O)CC1
Nc1ccc(-c2ncc[nH]2)cc1
NC(=O)C1CCN(c2ncccc2CNc2nc(Nc3ccc(-c4ncc[nH]4)cc3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(Cl)cc3Cl)n2)CC1
BRD4
0
285,022,509
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc(-c2ccncc2)[nH]1
Cl.Cl.NCC(=O)NCCN1CCOCC1
O=C(CNc1nc(NCc2nnc(-c3ccncc3)[nH]2)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1)NCCN1CCOCC1
BRD4
0
219,101,935
O=C(Nc1cnc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(CN)CN(C)C
CC(C)(C)NS(=O)(=O)c1cccc(N)c1
CCOC(CNc1nc(Nc2cccc(S(=O)(=O)NC(C)(C)C)c2)nc(Nc2cnc(Cl)cc2C(=O)N[Dy])n1)CN(C)C
HSA
0
141,355,656
O=C(Nc1c(C(=O)O)cnn1-c1ccc(F)cc1)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Cc1cc(CN)cc(Cl)n1.Cl.Cl
Cc1cc(CNc2nc(NCc3ccccc3CS(=O)(=O)N3CCOCC3)nc(Nc3c(C(=O)N[Dy])cnn3-c3ccc(F)cc3)n2)cc(Cl)n1
BRD4
0
139,725,633
O=C(Nc1c(C(=O)O)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc([N+](=O)[O-])c(N)n1
NCc1nc2ccccc2s1
COc1ccc([N+](=O)[O-])c(Nc2nc(NCc3nc4ccccc4s3)nc(Nc3c(C(=O)O)cccc3C(=O)N[Dy])n2)n1
BRD4
0
143,950,886
O=C(Nc1c(Cl)c(Cl)nc(C(=O)O)c1Cl)OCC1c2ccccc2-c2ccccc21
CN(Cc1ccco1)Cc1ccccc1CN
Cn1nccc1[C@@H]1OCC[C@H]1CN
CN(Cc1ccco1)Cc1ccccc1CNc1nc(NC[C@@H]2CCO[C@H]2c2ccnn2C)nc(Nc2c(Cl)c(Cl)nc(C(=O)N[Dy])c2Cl)n1
sEH
0
62,997,379
Cn1cc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)c2ccccc21
Nc1ccc(Cl)cn1
C=C1CCC(CN)CC1.Cl
C=C1CCC(CNc2nc(Nc3ccc(Cl)cn3)nc(N[C@H](Cc3cn(C)c4ccccc34)C(=O)N[Dy])n2)CC1
HSA
0
64,384,070
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
CCOC(=O)c1ccc(O)c(N)c1
Nc1ncc(Cl)c(Cl)n1
CCOC(=O)c1ccc(O)c(Nc2nc(Nc3ncc(Cl)c(Cl)n3)nc(N[C@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)c1
sEH
0
31,685,837
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c(OC)c1
CCC(CC)(CN)OC
Nc1ccc2c(c1)C(=O)CCC2
CCC(CC)(CNc1nc(Nc2ccc3c(c2)C(=O)CCC3)nc(Nc2cc(OC)cc(OC)c2C(=O)N[Dy])n1)OC
sEH
0
185,125,610
O=C(Nc1ccc(C(=O)O)c(Cl)c1)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1[N+](=O)[O-]
COc1ccc(N)c(Cl)c1
COc1ccc(Nc2nc(Nc3ccc(C(=O)N[Dy])c(Cl)c3)nc(Nc3cccnc3[N+](=O)[O-])n2)c(Cl)c1
sEH
0
170,173,925
O=C(Nc1cc(Cl)nc(C(=O)O)c1Cl)OCC1c2ccccc2-c2ccccc21
COC1(OC)CC(CN)C1
CC1(CN)CCC2(CC1)OCCO2
COC1(OC)CC(CNc2nc(NCC3(C)CCC4(CC3)OCCO4)nc(Nc3cc(Cl)nc(C(=O)N[Dy])c3Cl)n2)C1
sEH
0
147,441,778
O=C(Nc1c(Cl)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccn1
Cl.Cl.NCCNC(=O)c1cnccn1
Cc1cc(Nc2nc(NCCNC(=O)c3cnccn3)nc(Nc3c(Cl)cccc3C(=O)N[Dy])n2)ccn1
HSA
0
169,406,852
O=C(Nc1cc(Cl)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NC1CCC(=O)CC1
NCCc1nccc(C2CC2)n1
O=C1CCC(Nc2nc(NCCc3nccc(C4CC4)n3)nc(Nc3cc(Cl)ccc3C(=O)N[Dy])n2)CC1
sEH
0
28,683,453
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)cc(F)c1
CC(C)(C)OC(=O)N1CCC(n2cc(N)cn2)CC1
COc1c(F)ccc(C(=O)N[Dy])c1Nc1nc(Nc2cc(C)cc(F)c2)nc(Nc2cnn(C3CCN(C(=O)OC(C)(C)C)CC3)c2)n1
BRD4
0