id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
227,652,325
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ccc1Cl
Cc1cc(O)cc(C)c1N
Cc1cc(O)cc(C)c1Nc1nc(Nc2nc3ccc(C(=O)N[Dy])cc3s2)nc(Nc2nc(Cl)ccc2Cl)n1
HSA
0
52,566,165
Cc1cc(Cl)cc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cn1
NCCC(O)C1CCCC1
COc1ccc(Nc2nc(NCCC(O)C3CCCC3)nc(Nc3c(C)cc(Cl)cc3C(=O)N[Dy])n2)cn1
BRD4
0
272,655,779
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cnc(CN)cn1.Cl.Cl
Cl.NCCC(=O)NCc1ccccc1
COc1cnc(CNc2nc(NCCC(=O)NCc3ccccc3)nc(N[C@H](CC(=O)N[Dy])Cc3cccs3)n2)cn1
sEH
0
191,771,472
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
CC(=O)SCCN.Cl
Cl.NCC12CC3CC(CC(C3)C1)C2
CC(=O)SCCNc1nc(NCC23CC4CC(CC(C4)C2)C3)nc(Nc2ccc(C(=O)N[Dy])cc2O)n1
BRD4
0
96,417,672
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC(F)(F)CC1CC1
Cc1conc1CN
Cc1conc1CNc1nc(NCC(F)(F)CC2CC2)nc(N[C@@H](Cc2ccc(Cl)cc2Cl)C(=O)N[Dy])n1
BRD4
0
213,545,012
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
C#Cc1cccc(N)c1
Cl.NCCc1cc(Br)c(Br)s1
C#Cc1cccc(Nc2nc(NCCc3cc(Br)c(Br)s3)nc(Nc3cccc(I)c3C(=O)N[Dy])n2)c1
sEH
0
212,788,300
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1c([C@@H]2[C@@H](CN)CC(=O)N2C)cnn1C
Nc1ncc[nH]c1=O
Cc1c([C@@H]2[C@@H](CNc3nc(Nc4cccc(F)c4C(=O)N[Dy])nc(Nc4ncc[nH]c4=O)n3)CC(=O)N2C)cnn1C
HSA
0
157,316,291
O=C(Nc1cc(Br)c(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1nc(N)ccc1Cl
Cl.Cl.NCC1(N2CCOCC2)CCOCC1
Cc1nc(Nc2nc(NCC3(N4CCOCC4)CCOCC3)nc(Nc3cc(Br)c(Cl)cc3C(=O)N[Dy])n2)ccc1Cl
sEH
0
274,350,275
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Nc1ccc(Cl)c(C(F)(F)F)c1
Nc1ccc2c(c1)CC(=O)N2
O=C(C[C@H](Nc1nc(Nc2ccc3c(c2)CC(=O)N3)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1)c1ccc(F)cc1)N[Dy]
sEH
0
14,859,237
CC(C)(C)OC(=O)N1CCN(C(=O)OCC2c3ccccc3-c3ccccc32)C1C(=O)O
Cn1nccc1CN1C[C@@H](F)C[C@H]1CN
Nc1n[nH]c2c(F)c(F)ccc12
Cn1nccc1CN1C[C@@H](F)C[C@H]1CNc1nc(Nc2n[nH]c3c(F)c(F)ccc23)nc(N2CCN(C(=O)OC(C)(C)C)C2C(=O)N[Dy])n1
BRD4
0
288,833,390
O=C(O)[C@H]1CCCCN1C(=O)OCC1c2ccccc2-c2ccccc21
CCON(C)C(=O)CN.Cl
Nc1ncco1
CCON(C)C(=O)CNc1nc(Nc2ncco2)nc(N2CCCC[C@@H]2C(=O)N[Dy])n1
sEH
0
273,963,073
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Cl.Cl.NCc1cn[nH]c1
Cl.NCC1CCCC1
O=C(C[C@H](Nc1nc(NCc2cn[nH]c2)nc(NCC2CCCC2)n1)c1ccc(F)cc1)N[Dy]
HSA
0
235,792,968
O=C(O)C1c2ccccc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(CC(F)F)CC1
CCOC(=O)c1cnn(C)c1N
CCOC(=O)c1cnn(C)c1Nc1nc(NCC2CCN(CC(F)F)CC2)nc(N2Cc3ccccc3C2C(=O)N[Dy])n1
BRD4
0
163,783,758
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1O
Cl.Cl.NCc1nc2c(s1)CCC2
Cc1cc(Nc2nc(NCc3nc4c(s3)CCC4)nc(Nc3cc(C(=O)N[Dy])ccc3Br)n2)ccc1O
BRD4
0
194,271,348
O=C(Nc1ccc(C(=O)O)cn1)OCC1c2ccccc2-c2ccccc21
Cc1cc(C#N)cnc1N
Cl.NCCOc1ccc(F)c(F)c1
Cc1cc(C#N)cnc1Nc1nc(NCCOc2ccc(F)c(F)c2)nc(Nc2ccc(C(=O)N[Dy])cn2)n1
BRD4
0
10,252,049
C=CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1nnc(N)s1
CCOC(=O)c1c(C)csc1N
C=CC[C@H](Nc1nc(Nc2nnc(C)s2)nc(Nc2scc(C)c2C(=O)OCC)n1)C(=O)N[Dy]
sEH
0
192,929,735
O=C(Nc1ccc(C(=O)O)cc1OC(F)(F)F)OCC1c2ccccc2-c2ccccc21
CCC(C)(O)CCN
CN(C)C(CN)c1ccco1
CCC(C)(O)CCNc1nc(NCC(c2ccco2)N(C)C)nc(Nc2ccc(C(=O)N[Dy])cc2OC(F)(F)F)n1
sEH
0
153,248,262
O=C(Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I)OCC1c2ccccc2-c2ccccc21
NC1COC1
Cl.Cl.NCc1cc(=O)nc[nH]1
O=C(O)c1c(I)c(Nc2nc(NCc3cc(=O)nc[nH]3)nc(NC3COC3)n2)c(I)c(C(=O)N[Dy])c1I
BRD4
0
22,530,669
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
NCC1(O)CCSC1
Cc1cccc2oc(CCN)nc12.Cl.Cl
CCOc1cc(Nc2nc(NCCc3nc4c(C)cccc4o3)nc(NCC3(O)CCSC3)n2)c(Cl)cc1C(=O)N[Dy]
BRD4
0
71,013,256
O=C(CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OC1CCCCC1
COC(=O)c1cscc1N.Cl
Cc1cnc(N)s1
COC(=O)c1cscc1Nc1nc(Nc2ncc(C)s2)nc(N[C@@H](CCC(=O)OC2CCCCC2)C(=O)N[Dy])n1
HSA
0
47,860,450
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccncn1
Nc1cnc(Cl)c(Cl)c1
Cc1cc(Br)c(C(=O)N[Dy])cc1Nc1nc(Nc2cnc(Cl)c(Cl)c2)nc(Nc2ccncn2)n1
HSA
0
106,797,247
O=C(N[C@@H](Cc1ccsc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)(C)c1ccc(O)c(N)c1
Cn1ccc(N)n1
Cn1ccc(Nc2nc(Nc3cc(C(C)(C)C)ccc3O)nc(N[C@@H](Cc3ccsc3)C(=O)N[Dy])n2)n1
HSA
0
109,416,710
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCCN1CCNC(=O)C1
Nc1nc2ccccc2s1
O=C1CN(CCCNc2nc(Nc3nc4ccccc4s3)nc(N[C@@H](Cc3cscn3)C(=O)N[Dy])n2)CCN1
sEH
0
270,291,873
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cccnc1N
Cc1cc(N)nn1C
CCOC(=O)c1cccnc1Nc1nc(Nc2cc(C)n(C)n2)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(I)cc2)n1
BRD4
0
222,646,138
O=C(Nc1nc(-c2ccc(C(=O)O)cc2)cs1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)c(Cl)n1
NCC1(CO)CC=CC1
Cc1ccc(Nc2nc(NCC3(CO)CC=CC3)nc(Nc3nc(-c4ccc(C(=O)N[Dy])cc4)cs3)n2)c(Cl)n1
HSA
0
176,405,515
O=C(Nc1cc(F)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1Cl
CC(CN)Cn1cccn1
CC(CNc1nc(Nc2cc(F)ccc2C(=O)N[Dy])nc(Nc2cccnc2Cl)n1)Cn1cccn1
HSA
0
29,074,083
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
NCC12CCCC(CO1)C2
Cl.Cl.NCc1nc2cnccc2s1
COc1c(F)ccc(C(=O)N[Dy])c1Nc1nc(NCc2nc3cnccc3s2)nc(NCC23CCCC(CO2)C3)n1
BRD4
0
5,119,436
C#CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC(=O)NC1CCCC1
Cl.NCCC(=O)NCc1ccccc1
C#CC[C@H](Nc1nc(NCCC(=O)NCc2ccccc2)nc(NCCC(=O)NC2CCCC2)n1)C(=O)N[Dy]
sEH
0
193,335,328
O=C(Nc1ccc(C(=O)O)cc1OC(F)(F)F)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(-n2cncn2)cc1
Nc1cc(Br)ccn1
O=C(N[Dy])c1ccc(Nc2nc(NCc3ccc(-n4cncn4)cc3)nc(Nc3cc(Br)ccn3)n2)c(OC(F)(F)F)c1
HSA
0
196,085,223
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
Nc1nccc2cccnc12
Cl.NCC1CCN(c2ccc(Br)cc2)C1
O=C(N[Dy])c1ccc(Nc2nc(NCC3CCN(c4ccc(Br)cc4)C3)nc(Nc3nccc4cccnc34)n2)cn1
BRD4
0
180,194,521
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1nc(CN)ccc1C(C)O.Cl.Cl
NCCc1ccncc1F
Cc1nc(CNc2nc(NCCc3ccncc3F)nc(Nc3ccc(Br)c(C(=O)N[Dy])c3)n2)ccc1C(C)O
HSA
0
215,515,812
O=C(Nc1cccc([N+](=O)[O-])c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(-n2cccc2)cc1
Nc1ccc2c(c1)CNC2=O
O=C1NCc2cc(Nc3nc(Nc4ccc(-n5cccc5)cc4)nc(Nc4cccc([N+](=O)[O-])c4C(=O)N[Dy])n3)ccc21
BRD4
0
126,522,140
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
CN1CC(CN)CC1=O
Nc1ncnc(=O)[nH]1
CN1CC(CNc2nc(Nc3ncnc(=O)[nH]3)nc(N[C@H](Cc3ccccc3Cl)C(=O)N[Dy])n2)CC1=O
sEH
0
174,765,182
O=C(Nc1cc(F)cc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1nncn1CCCN.Cl
Cl.NCC1OCCc2ccsc21
Cc1nncn1CCCNc1nc(NCC2OCCc3ccsc32)nc(Nc2cc(F)cc(F)c2C(=O)N[Dy])n1
sEH
0
181,787,253
O=C(Nc1ccc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(O)cn1
NCC1CCC2CC2C1
O=C(N[Dy])c1cc(Br)ccc1Nc1nc(NCC2CCC3CC3C2)nc(Nc2ccc(O)cn2)n1
BRD4
0
187,831,693
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cc1nccn1-c1ncccc1CN
CC(C)(C)c1cc(N)n[nH]1
Cc1nccn1-c1ncccc1CNc1nc(Nc2ccc(C(=O)N[Dy])cc2)nc(Nc2cc(C(C)(C)C)[nH]n2)n1
HSA
0
166,026,695
O=C(Nc1cc(C(=O)O)ccc1C(F)(F)F)OCC1c2ccccc2-c2ccccc21
Cc1cnc(N)s1
Nc1cncnc1
Cc1cnc(Nc2nc(Nc3cncnc3)nc(Nc3cc(C(=O)N[Dy])ccc3C(F)(F)F)n2)s1
sEH
0
154,819,430
O=C(Nc1c(OC(F)(F)F)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(CN)CN(C)C
Nc1ncc(F)cn1
CCOC(CNc1nc(Nc2ncc(F)cn2)nc(Nc2c(OC(F)(F)F)cccc2C(=O)N[Dy])n1)CN(C)C
sEH
0
93,410,314
O=C(N[C@@H](Cc1ccc(Br)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cccc(C(F)(F)F)c1
Nc1nccnc1Cl
O=C(N[Dy])[C@H](Cc1ccc(Br)cc1)Nc1nc(NCc2cccc(C(F)(F)F)c2)nc(Nc2nccnc2Cl)n1
HSA
0
283,209,266
O=C(O)[C@@H]1CSCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1nc(-c2cccnc2)cs1
CS(=O)CC(O)CN.Cl
CS(=O)CC(O)CNc1nc(Nc2nc(-c3cccnc3)cs2)nc(N2CSC[C@H]2C(=O)N[Dy])n1
sEH
0
242,094,676
O=C(O)COc1cccc(-c2csc(NC(=O)OCC3c4ccccc4-c4ccccc43)n2)c1
COc1c(N)cccc1F
Cl.NCC(F)(F)C(N)=O
COc1c(F)cccc1Nc1nc(NCC(F)(F)C(N)=O)nc(Nc2nc(-c3cccc(OCC(=O)N[Dy])c3)cs2)n1
HSA
0
136,986,354
O=C(Nc1c(C(=O)O)cc(Cl)c(Br)c1F)OCC1c2ccccc2-c2ccccc21
NCc1cc(F)cc(F)c1
NCCC(=O)N1CCN(c2ccccn2)CC1
O=C(N[Dy])c1cc(Cl)c(Br)c(F)c1Nc1nc(NCCC(=O)N2CCN(c3ccccn3)CC2)nc(NCc2cc(F)cc(F)c2)n1
BRD4
0
251,809,663
O=C(O)C[C@@H](Cc1cccc(F)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
CN(CC(F)(F)F)C(=O)CN.Cl
Nc1ccc2c(c1)OCO2
CN(CC(F)(F)F)C(=O)CNc1nc(Nc2ccc3c(c2)OCO3)nc(N[C@@H](CC(=O)N[Dy])Cc2cccc(F)c2)n1
HSA
0
134,655,315
O=C(Nc1c(Br)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1nncn1CCCN.Cl
Cc1nncn1CCCNc1nc(NCc2cnc3n2CCOC3)nc(Nc2c(Br)cc(F)cc2C(=O)N[Dy])n1
BRD4
0
204,059,206
O=C(Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
CSc1ccc(CN)o1.Cl
CCn1cc2cc(N)ccc2n1
CCn1cc2cc(Nc3nc(NCc4ccc(SC)o4)nc(Nc4ccc([N+](=O)[O-])c(C(=O)N[Dy])c4)n3)ccc2n1
HSA
0
237,242,084
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
NCc1cccnc1
Nc1ccc(-c2cnco2)cc1
O=C(CC(Nc1nc(NCc2cccnc2)nc(Nc2ccc(-c3cnco3)cc2)n1)c1ccc(Br)cc1)N[Dy]
sEH
0
262,851,138
O=C(O)C[C@H](C/C=C/c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cnc(N)nc1
Cc1cc(N)ncc1[N+](=O)[O-]
COc1cnc(Nc2nc(Nc3cc(C)c([N+](=O)[O-])cn3)nc(N[C@@H](C/C=C/c3ccccc3)CC(=O)N[Dy])n2)nc1
BRD4
0
218,271,074
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ncc1Cl
NCc1cc(C(F)F)on1
Cc1cc(Nc2nc(NCc3cc(C(F)F)on3)nc(Nc3ccnc(C(=O)N[Dy])c3)n2)ncc1Cl
sEH
0
112,439,079
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
CO[C@@H]1COC[C@H]1n1cc(CN)nn1.Cl
CC1(C)NC(=O)N(CCCN)C1=O.Cl
CO[C@@H]1COC[C@H]1n1cc(CNc2nc(NCCCN3C(=O)NC(C)(C)C3=O)nc(N[C@H](C(=O)N[Dy])C3CCCC3)n2)nn1
BRD4
0
144,876,437
O=C(Nc1c(Cl)c(Cl)nc(C(=O)O)c1Cl)OCC1c2ccccc2-c2ccccc21
Nc1ncccc1CO
CC1CCCC(CN)O1
CC1CCCC(CNc2nc(Nc3ncccc3CO)nc(Nc3c(Cl)c(Cl)nc(C(=O)N[Dy])c3Cl)n2)O1
sEH
0
4,820,095
C#CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCC(=O)Nc1nccs1
NCC1CS(=O)(=O)c2ccccc21
C#CC[C@H](Nc1nc(NCC(=O)Nc2nccs2)nc(NCC2CS(=O)(=O)c3ccccc32)n1)C(=O)N[Dy]
HSA
0
191,392,075
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC2C=CC1C2
CSCc1nnc(CN)[nH]1.Cl
CSCc1nnc(CNc2nc(NCC3(CO)CC4C=CC3C4)nc(Nc3ccc(C(=O)N[Dy])cc3F)n2)[nH]1
HSA
0
86,517,707
O=C(N[C@@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.Cn1cncc1CN
CN1CC(CN)CC1=O
CN1CC(CNc2nc(NCc3cncn3C)nc(N[C@@H](C(=O)N[Dy])C3CCCCC3)n2)CC1=O
sEH
0
165,528,231
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cnc(Cl)cc1Cl
NCc1ccsc1Br
O=C(N[Dy])c1ccc(C(=O)O)c(Nc2nc(NCc3ccsc3Br)nc(Nc3cnc(Cl)cc3Cl)n2)c1
BRD4
0
5,362,203
C#CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cccnc1[N+](=O)[O-]
Cc1cc(N)ccc1O
C#CC[C@H](Nc1nc(Nc2ccc(O)c(C)c2)nc(Nc2cccnc2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
0
287,099,243
O=C(O)[C@@H]1Cc2ccccc2N1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCC2(CCC2)CO1
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NCC3CCC4(CCC4)CO3)nc(N3c4ccccc4C[C@H]3C(=O)N[Dy])n2)c1
sEH
0
145,007,131
O=C(Nc1c(Cl)cc(Cl)nc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cncnc1N
Nc1ccc2cn[nH]c2c1
CCOC(=O)c1cncnc1Nc1nc(Nc2ccc3cn[nH]c3c2)nc(Nc2c(Cl)cc(Cl)nc2C(=O)N[Dy])n1
HSA
0
268,631,876
O=C(O)C[C@H](Cc1ccc(Cl)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)c1ccc(Cl)cc1
Nc1nc(OCc2ccccc2)c2nc[nH]c2n1
O=C(C[C@H](Cc1ccc(Cl)cc1)Nc1nc(NCCS(=O)(=O)c2ccc(Cl)cc2)nc(Nc2nc(OCc3ccccc3)c3nc[nH]c3n2)n1)N[Dy]
sEH
0
222,165,142
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1Cl
Cc1cc(CN)ccc1Oc1ccc(Cl)cc1Cl.Cl
Cc1cc(CNc2nc(Nc3cnccc3C(=O)N[Dy])nc(Nc3cccnc3Cl)n2)ccc1Oc1ccc(Cl)cc1Cl
HSA
0
38,239,321
COc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cnc(SC)nc1N
NCC1(CO)CC=CC1
CCOC(=O)c1cnc(SC)nc1Nc1nc(NCC2(CO)CC=CC2)nc(Nc2c(OC)cccc2C(=O)N[Dy])n1
HSA
0
56,488,139
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Nc1ccc(N2CCCC2=O)cc1
Nc1ccc(N2CCOCC2=O)cc1
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(Nc3ccc(N4CCCC4=O)cc3)nc(Nc3ccc(N4CCOCC4=O)cc3)n2)cc1
sEH
0
80,009,639
O=C(NC1(C(=O)O)CCOCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCNC(=O)c1cnccn1
Nc1nc2ccccc2s1
O=C(NCCNc1nc(Nc2nc3ccccc3s2)nc(NC2(C(=O)N[Dy])CCOCC2)n1)c1cnccn1
sEH
0
237,896,995
O=C(O)CC1(CNC(=O)OCC2c3ccccc3-c3ccccc32)CCCCC1
Cc1ccc(N)c(Cl)n1
COc1c(N)ncnc1Cl
COc1c(Cl)ncnc1Nc1nc(NCC2(CC(=O)N[Dy])CCCCC2)nc(Nc2ccc(C)nc2Cl)n1
HSA
0
173,916,780
O=C(Nc1cc(F)c(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cn1ccnc1N
NCCC(=O)N1CCN(c2ccccn2)CC1
Cn1ccnc1Nc1nc(NCCC(=O)N2CCN(c3ccccn3)CC2)nc(Nc2cc(F)c(F)cc2C(=O)N[Dy])n1
BRD4
0
275,314,597
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1Cl
NCCC1SCCS1
COC(=O)c1cc(N)ccc1C
COC(=O)c1cc(Nc2nc(NCCC3SCCS3)nc(N[C@@H](CC(=O)N[Dy])c3cccc(Cl)c3Cl)n2)ccc1C
HSA
0
185,048,541
O=C(Nc1ccc(C(=O)O)c(Cl)c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)c(F)c1
Nc1cc(C2CC2)[nH]n1
O=C(N[Dy])c1ccc(Nc2nc(Nc3ccc(N4CCOCC4)c(F)c3)nc(Nc3cc(C4CC4)[nH]n3)n2)cc1Cl
BRD4
0
58,384,496
Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.NCc1cc(F)c(Cl)cc1F
Cl.NCc1cc(Br)no1
Cc1ccc(Nc2nc(NCc3cc(Br)no3)nc(NCc3cc(F)c(Cl)cc3F)n2)c(C(=O)N[Dy])c1
sEH
0
194,973,175
O=C(Nc1ccc(C(=O)O)cn1)OCC1c2ccccc2-c2ccccc21
Nc1nc(Cl)ncc1Cl
Cc1cn(-c2cc(N)cc(C(F)(F)F)c2)cn1
Cc1cn(-c2cc(Nc3nc(Nc4ccc(C(=O)N[Dy])cn4)nc(Nc4nc(Cl)ncc4Cl)n3)cc(C(F)(F)F)c2)cn1
HSA
0
137,599,722
O=C(Nc1c(C(=O)O)ccc(Br)c1F)OCC1c2ccccc2-c2ccccc21
Cc1c(Br)cncc1CN.Cl.Cl
N#Cc1ccccc1N
Cc1c(Br)cncc1CNc1nc(Nc2ccccc2C#N)nc(Nc2c(C(=O)N[Dy])ccc(Br)c2F)n1
BRD4
0
130,804,061
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
CC1(C)CCOC1CCN
Nc1nnn[nH]1
CC1(C)CCOC1CCNc1nc(Nc2nnn[nH]2)nc(N[C@H]2CC[C@@H](C(=O)N[Dy])C2)n1
sEH
0
154,646,488
O=C(Nc1c(I)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1nc(-c2ccccc2Cl)cs1
CC(O)(CN)c1ccsc1
CC(O)(CNc1nc(Nc2nc(-c3ccccc3Cl)cs2)nc(Nc2c(I)cccc2C(=O)N[Dy])n1)c1ccsc1
HSA
0
4,494,416
C#CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CN(C)C(=O)C1CCC(CN)O1.Cl
COc1ncc(N)cc1C(F)(F)F
C#CC[C@H](Nc1nc(NCC2CCC(C(=O)N(C)C)O2)nc(Nc2cnc(OC)c(C(F)(F)F)c2)n1)C(=O)N[Dy]
sEH
0
145,662,235
O=C(Nc1c(Cl)cc(Cl)nc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1OCCc2ccccc21
CC1CCCC(CN)O1
CC1CCCC(CNc2nc(NCCC3OCCc4ccccc43)nc(Nc3c(Cl)cc(Cl)nc3C(=O)N[Dy])n2)O1
HSA
0
131,352,232
O=C(N[C@H]1CC[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Cl.NCCOCC(F)F
Cn1cc(C2(CN)CCCO2)cn1
Cn1cc(C2(CNc3nc(NCCOCC(F)F)nc(N[C@H]4CC[C@@H](C(=O)N[Dy])C4)n3)CCCO2)cn1
HSA
0
156,780,173
O=C(Nc1cc(-n2cccn2)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2c(=O)[nH][nH]c(=O)c12
Nc1cc(Br)cn2ccnc12
O=C(N[Dy])c1ccc(-n2cccn2)cc1Nc1nc(Nc2cccc3c(=O)[nH][nH]c(=O)c23)nc(Nc2cc(Br)cn3ccnc23)n1
sEH
0
172,593,297
O=C(Nc1cc(F)c(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.Cn1cncc1CN
Nc1cccc(F)n1
Cn1cncc1CNc1nc(Nc2cccc(F)n2)nc(Nc2cc(F)c(Br)cc2C(=O)N[Dy])n1
BRD4
0
254,634,808
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
NC[C@@H]1CCC(=O)N1
Cl.Cl.NCCN1CCS(=O)CC1
O=C(C[C@@H](Cc1cccs1)Nc1nc(NCCN2CCS(=O)CC2)nc(NC[C@@H]2CCC(=O)N2)n1)N[Dy]
HSA
0
83,214,918
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cnc(CCN)s1.Cl.Cl
C[Si](C)(C)C#Cc1ccc(N)cn1
Cc1cnc(CCNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3ccc(C#C[Si](C)(C)C)nc3)n2)s1
BRD4
0
123,973,589
O=C(N[C@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(F)c(F)cc1[N+](=O)[O-]
Nc1cnc(Cl)c(Cl)c1
O=C(N[Dy])[C@@H](Cc1ccc(F)c(F)c1)Nc1nc(Nc2cnc(Cl)c(Cl)c2)nc(Nc2cc(F)c(F)cc2[N+](=O)[O-])n1
sEH
0
21,511,916
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cccc(C(F)(F)F)n1
Nc1ncnc(=O)[nH]1
CCCCC(Nc1nc(NCc2cccc(C(F)(F)F)n2)nc(Nc2ncnc(=O)[nH]2)n1)C(=O)N[Dy]
sEH
0
237,382,522
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1ccc2c(c1)oc1ccccc12
Nc1ccc(N2CCOCC2=O)cc1
O=C(CC(Nc1nc(Nc2ccc(N3CCOCC3=O)cc2)nc(Nc2ccc3c(c2)oc2ccccc23)n1)c1ccc(Br)cc1)N[Dy]
HSA
0
180,242,744
O=C(Nc1ccc(Br)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCc1nc2c(s1)COCC2
Cn1cc(C2(CN)CCCO2)cn1
Cn1cc(C2(CNc3nc(NCCc4nc5c(s4)COCC5)nc(Nc4ccc(Br)c(C(=O)N[Dy])c4)n3)CCCO2)cn1
sEH
0
216,984,720
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1C
Cc1cc(N)nnc1Cl
COC(=O)c1cc(Nc2nc(Nc3cc(C)c(Cl)nn3)nc(Nc3cccnc3C(=O)N[Dy])n2)ccc1C
BRD4
0
241,153,873
O=C(O)COC[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(O)ccc1N
Nc1ccc2nccn2c1
Cc1cc(O)ccc1Nc1nc(Nc2ccc3nccn3c2)nc(N2CCC[C@@H]2COCC(=O)N[Dy])n1
HSA
0
8,409,490
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC[C@@H]1COC[C@H]1O
COC(=O)c1ccc(N)cc1O
C=CCC[C@@H](Nc1nc(NCC[C@@H]2COC[C@H]2O)nc(Nc2ccc(C(=O)OC)c(O)c2)n1)C(=O)N[Dy]
HSA
0
17,235,868
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc(Cl)c(F)c1
CC1(C)OB(c2ccc(N)cc2)OC1(C)C
CC(C)(C)OCC(Nc1nc(Nc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)nc(Nc2ccc(Cl)c(F)c2)n1)C(=O)N[Dy]
HSA
0
273,846,561
O=C(O)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(F)cc1
Cc1ccc(F)c(N)c1
Cl.Cn1cc(CN)c(Br)n1
Cc1ccc(F)c(Nc2nc(NCc3cn(C)nc3Br)nc(N[C@@H](CC(=O)N[Dy])c3ccc(F)cc3)n2)c1
BRD4
0
129,668,864
O=C(N[C@H]1CCC[C@@H]1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)(C#N)c1ccc(N)cc1
Cc1nn(C)c2ncc(CN)cc12.Cl
Cc1nn(C)c2ncc(CNc3nc(Nc4ccc(C(C)(C)C#N)cc4)nc(N[C@H]4CCC[C@@H]4C(=O)N[Dy])n3)cc12
sEH
0
135,379,861
O=C(Nc1c(Br)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cnc(N)cn1
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(Nc2cnc(OC)cn2)nc(Nc2c(Br)cccc2C(=O)N[Dy])n1
HSA
0
214,940,433
O=C(Nc1cccc([N+](=O)[O-])c1C(=O)O)OCC1c2ccccc2-c2ccccc21
CS(=O)(=O)Nc1cccc(N)c1
Nc1nc(Cl)c2cc[nH]c2n1
CS(=O)(=O)Nc1cccc(Nc2nc(Nc3nc(Cl)c4cc[nH]c4n3)nc(Nc3cccc([N+](=O)[O-])c3C(=O)N[Dy])n2)c1
BRD4
0
53,103,625
Cc1cc(Cl)cc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
NCc1ccc2[nH]ccc2c1
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
Cc1cc(Cl)cc(C(=O)N[Dy])c1Nc1nc(NCc2ccc3[nH]ccc3c2)nc(Nc2n[nH]c3c(Cl)cc([N+](=O)[O-])cc23)n1
HSA
0
241,430,621
O=C(O)COC[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cocn1
Nc1nc(-c2ccccc2Cl)cs1
O=C(COC[C@H]1CCCN1c1nc(NCc2cocn2)nc(Nc2nc(-c3ccccc3Cl)cs2)n1)N[Dy]
sEH
0
79,754,587
O=C(NC1(C(=O)O)CCOCC1)OCC1c2ccccc2-c2ccccc21
COCCNC(=O)CN.Cl
Cc1nc(Cl)c(N)c(Cl)n1
COCCNC(=O)CNc1nc(Nc2c(Cl)nc(C)nc2Cl)nc(NC2(C(=O)N[Dy])CCOCC2)n1
HSA
0
220,164,897
O=C(Nc1cncc(C(=O)O)n1)OCC1c2ccccc2-c2ccccc21
CCC#CCN
Cl.Nc1ccc(O)cc1Cl
CCC#CCNc1nc(Nc2cncc(C(=O)N[Dy])n2)nc(Nc2ccc(O)cc2Cl)n1
BRD4
0
81,329,094
O=C(NC1(C(=O)O)CCc2ccccc21)OCC1c2ccccc2-c2ccccc21
N#Cc1ccc(N)cc1
NCc1ccc(C(=O)N2CCCC2)cc1
N#Cc1ccc(Nc2nc(NCc3ccc(C(=O)N4CCCC4)cc3)nc(NC3(C(=O)N[Dy])CCc4ccccc43)n2)cc1
BRD4
0
117,792,037
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CN(C)C1(CN)CCSC1
Nc1nc(Br)cn2ccnc12
CN(C)C1(CNc2nc(Nc3nc(Br)cn4ccnc34)nc(N[C@H](Cc3cc(F)cc(F)c3)C(=O)N[Dy])n2)CCSC1
HSA
0
80,115,499
O=C(NC1(C(=O)O)CCOCC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC=C(Cl)Cl
Nc1cccc(OCc2ccccc2)c1
O=C(N[Dy])C1(Nc2nc(NCC=C(Cl)Cl)nc(Nc3cccc(OCc4ccccc4)c3)n2)CCOCC1
HSA
0
34,045,507
COc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
COc1ccc(O)c(N)c1
CSSCCN.Cl
COc1ccc(O)c(Nc2nc(NCCSSC)nc(Nc3cc(OC)ccc3C(=O)N[Dy])n2)c1
HSA
0
266,065,568
O=C(O)C[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1cc(Br)ccc1N
COc1ccc(Cl)c(N)c1.Cl
COc1ccc(Cl)c(Nc2nc(Nc3ccc(Br)cc3OC)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(C(F)(F)F)cc3)n2)c1
sEH
0
6,009,839
C=CCC(CC=C)(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCC1CC(CC(N)=O)CO1
Cl.Cl.NCc1ccc2ccccc2n1
C=CCC(CC=C)(Nc1nc(NCc2ccc3ccccc3n2)nc(NCC2CC(CC(N)=O)CO2)n1)C(=O)N[Dy]
sEH
0