id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
192,653,626
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
NCc1cccnc1
O=C(N[Dy])c1ccc(Nc2nc(NCc3cccnc3)nc(Nc3ccc(Cn4ccnc4)cc3)n2)c(O)c1
HSA
1
272,473,271
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cnc(N)cn1
Cl.NCC1CC2CC1C1CC21
CCOC(=O)c1cnc(Nc2nc(NCC3CC4CC3C3CC43)nc(N[C@H](CC(=O)N[Dy])Cc3cccs3)n2)cn1
sEH
1
19,507,866
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cccc2c(=O)[nH][nH]c(=O)c12
Cl.NCc1cc(Br)no1
CC(OC(C)(C)C)C(Nc1nc(NCc2cc(Br)no2)nc(Nc2cccc3c(=O)[nH][nH]c(=O)c23)n1)C(=O)N[Dy]
BRD4
1
83,416,685
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCS(=O)(=O)C1CCOCC1
NCc1cccnc1OC(F)F
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCCS(=O)(=O)C3CCOCC3)nc(NCc3cccnc3OC(F)F)n2)CC1
sEH
1
37,154,938
COc1ccc([C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
CCOC(=O)c1ncccc1N
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(Nc2cccnc2C(=O)OCC)nc(N[C@H](C(=O)N[Dy])c2ccc(OC)cc2)n1
HSA
1
187,441,461
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
CC(CCN)S(C)=O
NCC1CN2CCN1CC2
CC(CCNc1nc(NCC2CN3CCN2CC3)nc(Nc2ccc(C(=O)N[Dy])cc2)n1)S(C)=O
BRD4
1
82,612,901
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1
NCCc1ccncc1F
O=C(N[Dy])C1CCC(CNc2nc(NCCc3ccncc3F)nc(Nc3ccc(F)c(Cl)c3)n2)CC1
sEH
1
83,129,654
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(N)cccc1Br
Cl.NCc1nc2cc(F)ccc2o1
Cc1c(Br)cccc1Nc1nc(NCc2nc3cc(F)ccc3o2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
112,968,749
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
NCCC(=O)N1CCN(c2ccccn2)CC1
NCC1CCCCC(F)(F)C1
O=C(N[Dy])[C@@H](Nc1nc(NCCC(=O)N2CCN(c3ccccn3)CC2)nc(NCC2CCCCC(F)(F)C2)n1)C1CCCC1
sEH
1
82,160,375
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1sc(CCN)nc1-c1ccccc1.Cl.Cl
NCC1(O)CC1
Cc1sc(CCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(O)CC3)n2)nc1-c1ccccc1
sEH
1
111,215,049
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Cl.Cn1cc(N)ccc1=O
CCC(CNc1nc(Nc2ccc(=O)n(C)c2)nc(N[C@H](C(=O)N[Dy])C2CC2)n1)Oc1ccccc1C
BRD4
1
82,364,801
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnoc1C1CC1
Cc1ccc([N+](=O)[O-])c(N)n1
Cc1ccc([N+](=O)[O-])c(Nc2nc(NCc3cnoc3C3CC3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)n1
sEH
1
82,619,927
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)cc1Cl
Nc1ncnc2[nH]ncc12
O=C(N[Dy])C1CCC(CNc2nc(Nc3ccc(F)cc3Cl)nc(Nc3ncnc4[nH]ncc34)n2)CC1
sEH
1
17,029,698
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cn1ccc2cc(N)ccc21
N#Cc1c[nH]nc1N
Cn1ccc2cc(Nc3nc(Nc4n[nH]cc4C#N)nc(NC(COC(C)(C)C)C(=O)N[Dy])n3)ccc21
BRD4
1
199,052,423
O=C(Nc1ccc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Nc1ccc(F)cc1CO
O=C(N[Dy])c1cc(Cl)ccc1Nc1nc(NCCC2CSC2)nc(Nc2ccc(F)cc2CO)n1
sEH
1
81,861,911
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CN1CCN(CCN)CC1
CSC1(CN)CCOCC1.Cl
CSC1(CNc2nc(NCCN3CCN(C)CC3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)CCOCC1
sEH
1
256,836,595
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(C(F)(F)F)cc1
NCc1cccc(C(F)(F)F)n1
Cc1cc(CN)c(C)o1
Cc1cc(CNc2nc(NCc3cccc(C(F)(F)F)n3)nc(N[C@H](CC(=O)N[Dy])c3ccc(C(F)(F)F)cc3)n2)c(C)o1
HSA
1
110,280,429
O=C(N[C@@H]1CC[C@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
COc1cc(N)cc(OC)c1
NCc1cc2c(s1)CCSC2
COc1cc(Nc2nc(NCc3cc4c(s3)CCSC4)nc(N[C@@H]3CC[C@H](C(=O)N[Dy])C3)n2)cc(OC)c1
BRD4
1
72,901,440
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ncccc12
Cc1cnc(F)c(CN)c1
Cc1cnc(F)c(CNc2nc(Nc3cccc4ncccc34)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)c1
BRD4
1
20,566,854
CCC(C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc2c(c1)CNC2=O
NCc1noc2c1COCC2
CCC(C)C(Nc1nc(NCc2noc3c2COCC3)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
26,138,029
CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC1CCCCC1)C(=O)O
Nc1ncncc1Br
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ncncc4Br)nc(N(C)[C@@H](CC4CCCCC4)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
210,034,104
O=C(Nc1cccc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c(O)c(Cl)c1
Cc1ccc(C)c(CN)n1
Cc1ccc(C)c(CNc2nc(Nc3cccc(C(=O)N[Dy])c3)nc(Nc3cc(Cl)c(O)c(Cl)c3)n2)n1
BRD4
1
44,108,373
C[C@@H](OCc1ccccc1)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cn1cc(N)ccc1=O
COC(=O)c1scc(C)c1N
COC(=O)c1scc(C)c1Nc1nc(Nc2ccc(=O)n(C)c2)nc(N[C@H](C(=O)N[Dy])[C@@H](C)OCc2ccccc2)n1
BRD4
1
139,014,463
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cl.NCC1CCCC2(CCC2)C1O
O=C(N[Dy])c1ccc2ccccc2c1Nc1nc(NCc2cnc3n2CCOC3)nc(NCC2CCCC3(CCC3)C2O)n1
HSA
1
82,205,609
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc2ccccc2n1
Cl.NCC1CC2(C1)CC2(F)F
O=C(N[Dy])C1CCC(CNc2nc(NCc3ccc4ccccc4n3)nc(NCC3CC4(C3)CC4(F)F)n2)CC1
sEH
1
155,906,720
O=C(Nc1cc(-n2cccn2)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1nc(F)nc2nc[nH]c12
CCOC(=O)c1ncccc1Nc1nc(Nc2cc(-n3cccn3)ccc2C(=O)N[Dy])nc(Nc2nc(F)nc3nc[nH]c23)n1
sEH
1
250,251,005
O=C(O)C[C@@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
CC(C)(C)c1ocnc1CN.Cl
CC(C)(C)c1ocnc1CNc1nc(NCCC2CSC2)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(I)cc2)n1
sEH
1
258,370,947
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
CNC(=O)c1ccc(N)cc1F
COc1cccc(N)n1
CNC(=O)c1ccc(Nc2nc(Nc3cccc(OC)n3)nc(N[C@H](CC(=O)N[Dy])c3cccc(Cl)c3)n2)cc1F
BRD4
1
237,457,586
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1nc(Cl)ccc1Cl
CC(CN)S(=O)(=O)N1CCN(c2ccccc2)CC1.Cl.Cl
CC(CNc1nc(Nc2nc(Cl)ccc2Cl)nc(NC(CC(=O)N[Dy])c2ccc(Br)cc2)n1)S(=O)(=O)N1CCN(c2ccccc2)CC1
sEH
1
56,431,691
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Nc1cc(F)c(F)cc1[N+](=O)[O-]
Cl.NCC12CC3CC(CC(C3)C1)C2
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(Nc3cc(F)c(F)cc3[N+](=O)[O-])n2)cc1
sEH
1
188,268,144
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.NCc1nc2ccccc2o1
O=C(N[Dy])c1ccc(Nc2nc(NCc3nc4ccccc4o3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)cc1
BRD4
1
169,696,606
O=C(Nc1cc(Cl)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cccs1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCc4cccs4)nc(Nc4cc(Cl)ccc4C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
82,613,981
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1F
C[Si](C)(C)C#Cc1ccc(N)cn1
C[Si](C)(C)C#Cc1ccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3ccc(F)c(Cl)c3F)n2)cn1
sEH
1
237,377,484
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Nc1ccc2c(c1)COC2=O
Cl.NCC1Cc2ccccc2NC1=O
O=C(CC(Nc1nc(NCC2Cc3ccccc3NC2=O)nc(Nc2ccc3c(c2)COC3=O)n1)c1ccc(Br)cc1)N[Dy]
BRD4
1
1,509,092
C#CC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1ccncc1N
Nc1n[nH]c2cc(Cl)ccc12
C#CC[C@@H](Nc1nc(Nc2cnccc2C)nc(Nc2n[nH]c3cc(Cl)ccc23)n1)C(=O)N[Dy]
sEH
1
103,791,544
O=C(N[C@@H](Cc1cccnc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(Nc2cncc(OC)n2)nc(N[C@@H](Cc2cccnc2)C(=O)N[Dy])n1
HSA
1
118,222,718
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCC2(CCC2)CO1
Nc1ccc2cc(Br)ccc2c1
O=C(N[Dy])[C@@H](Cc1cc(F)cc(F)c1)Nc1nc(NCC2CCC3(CCC3)CO2)nc(Nc2ccc3cc(Br)ccc3c2)n1
sEH
1
55,130,471
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Nc1cncnc1
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(NCc2cnc3n2CCOC3)nc(Nc2cncnc2)n1
sEH
1
57,080,719
Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cc1cnc(N)s1
Cc1conc1CN
Cc1ccc(C[C@H](Nc2nc(NCc3nocc3C)nc(Nc3ncc(C)s3)n2)C(=O)N[Dy])cc1
HSA
1
183,479,785
O=C(Nc1ccc(C(=O)O)c(C(F)(F)F)c1)OCC1c2ccccc2-c2ccccc21
Cc1nnc(CCCN)s1.Cl
Nc1ncnc(Cl)c1Cl
Cc1nnc(CCCNc2nc(Nc3ccc(C(=O)N[Dy])c(C(F)(F)F)c3)nc(Nc3ncnc(Cl)c3Cl)n2)s1
HSA
1
10,657,474
C=CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(Cl)c(O)c(Cl)c1
NCCS(=O)Cc1ccccc1
C=CC[C@H](Nc1nc(NCCS(=O)Cc2ccccc2)nc(Nc2cc(Cl)c(O)c(Cl)c2)n1)C(=O)N[Dy]
HSA
1
167,196,182
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cc1sc(CN)nc1C(C)C
Cc1sc(CNc2nc(NCc3cncc(F)c3)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)nc1C(C)C
sEH
1
227,021,806
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
Cc1cccnc1NC(=O)CCN.Cl.Cl
Cl.Cl.NCc1cncc(F)c1
Cc1cccnc1NC(=O)CCNc1nc(NCc2cncc(F)c2)nc(Nc2nc3ccc(C(=O)N[Dy])cc3s2)n1
HSA
1
82,118,171
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccccc1-n1nc(C)c(CN)c1C.Cl.Cl
Nc1cc(Cl)c(F)c(Cl)c1
Cc1ccccc1-n1nc(C)c(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(Cl)c(F)c(Cl)c3)n2)c1C
sEH
1
122,524,566
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cnsc1
COC(=O)c1cc(N)ccc1Cl
COC(=O)c1cc(Nc2nc(NCc3cnsc3)nc(N[C@H](Cc3ccc(Cl)cc3)C(=O)N[Dy])n2)ccc1Cl
BRD4
1
109,397,938
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.Cn1cncc1CN
NCC1CCN(c2ccncc2)CC1
Cn1cncc1CNc1nc(NCC2CCN(c3ccncc3)CC2)nc(N[C@@H](Cc2cscn2)C(=O)N[Dy])n1
HSA
1
187,610,490
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
COC1CCC(CCN)CC1
Cn1nccc1N
COC1CCC(CCNc2nc(Nc3ccc(C(=O)N[Dy])cc3)nc(Nc3ccnn3C)n2)CC1
BRD4
1
102,278,823
O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)COC2=O
Cc1ccsc1CN
Cc1ccsc1CNc1nc(Nc2ccc3c(c2)COC3=O)nc(N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[Dy])n1
BRD4
1
213,835,514
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)n1
Cl.NCCC(=O)NCc1ccccc1
COc1cncc(Nc2nc(NCCC(=O)NCc3ccccc3)nc(Nc3cccc(I)c3C(=O)N[Dy])n2)n1
sEH
1
127,657,520
O=C(N[C@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cncc(N)c1
NCC1CS(=O)(=O)c2ccccc21
COC(=O)c1cncc(Nc2nc(NCC3CS(=O)(=O)c4ccccc43)nc(N[C@H](Cc3csc4ccccc34)C(=O)N[Dy])n2)c1
sEH
1
188,127,888
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
NCC1(Cc2ccccc2)CC1
Cc1ccc(N)c(CO)c1
Cc1ccc(Nc2nc(NCC3(Cc4ccccc4)CC3)nc(Nc3ccc(C(=O)N[Dy])cc3)n2)c(CO)c1
BRD4
1
81,956,738
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1cc(F)ccc1N
Nc1nc2c(Br)cccc2s1
COc1cc(F)ccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2nc3c(Br)cccc3s2)n1
sEH
1
83,614,676
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccccc1N1CCOCC1
Cc1[nH][nH]c(=O)c1CCN
Cc1[nH][nH]c(=O)c1CCNc1nc(NCc2ccccc2N2CCOCC2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1
sEH
1
178,542,342
O=C(Nc1cc([N+](=O)[O-])ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Br.Br.NCC1CCCN1c1cccnn1
O=C1NCc2cc(Nc3nc(NCC4CCCN4c4cccnn4)nc(Nc4cc([N+](=O)[O-])ccc4C(=O)N[Dy])n3)ccc21
BRD4
1
265,615,212
O=C(O)C[C@H](Cc1ccc(Br)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cc1ncc(N)cc1Br
Cc1ncc(Nc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(N[C@H](CC(=O)N[Dy])Cc3ccc(Br)cc3)n2)cc1Br
BRD4
1
267,334,906
O=C(O)C[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
Cl.Cl.Cn1cncc1CN
Cc1ccncc1Nc1nc(NCc2cncn2C)nc(N[C@H](CC(=O)N[Dy])Cc2ccc(Cl)c(Cl)c2)n1
HSA
1
82,437,299
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC(O)COc1ccccc1Br
Nc1nccc(=O)[nH]1
O=C(N[Dy])C1CCC(CNc2nc(NCC(O)COc3ccccc3Br)nc(Nc3nccc(=O)[nH]3)n2)CC1
sEH
1
106,325,281
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
Nc1cncc(F)c1
NC(=O)c1cc(CNc2nc(Nc3cncc(F)c3)nc(N[C@@H](Cc3cccs3)C(=O)N[Dy])n2)ccn1
HSA
1
181,775,769
O=C(Nc1ccc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1
Nc1nc(F)nc2nc[nH]c12
O=C(N[Dy])c1cc(Br)ccc1Nc1nc(Nc2ccc(N3CCC=C(N4CCOCC4)C3=O)cc2)nc(Nc2nc(F)nc3nc[nH]c23)n1
BRD4
1
109,036,050
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Nc1ccc2c(c1)CNC2=O
CCC(CNc1nc(Nc2ccc3c(c2)CNC3=O)nc(N[C@@H](Cc2cscn2)C(=O)N[Dy])n1)Oc1ccccc1C
BRD4
1
66,969,137
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cl.Cl.NCc1cncc(F)c1
Nc1nc2cc(Br)ccn2n1
N#Cc1ccc(C[C@H](Nc2nc(NCc3cncc(F)c3)nc(Nc3nc4cc(Br)ccn4n3)n2)C(=O)N[Dy])cc1
sEH
1
59,599,786
Cc1cccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1OCCc2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1cccc(C(=O)N[Dy])c1Nc1nc(NCCC2OCCc3ccccc32)nc(NCc2ccc(O)c3ncccc23)n1
HSA
1
82,794,386
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
C#CCOc1ccc(CN)cc1.Cl
Cc1cccc(N)c1Cl
C#CCOc1ccc(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cccc(C)c3Cl)n2)cc1
sEH
1
82,159,352
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1sc(CCN)nc1-c1ccccc1.Cl.Cl
COc1c(N)cccc1F
COc1c(F)cccc1Nc1nc(NCCc2nc(-c3ccccc3)c(C)s2)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
204,695,046
O=C(Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)COC2=O
Cl.Cl.NCc1nc2c(s1)CCC2
O=C1OCc2cc(Nc3nc(NCc4nc5c(s4)CCC5)nc(Nc4ccc([N+](=O)[O-])c(C(=O)N[Dy])c4)n3)ccc21
BRD4
1
74,310,690
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COC[C@H](CN)OC
Nc1ccc2c(c1)CNC2=O
COC[C@H](CNc1nc(Nc2ccc3c(c2)CNC3=O)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1)OC
BRD4
1
19,281,020
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC(=O)NC1CCCC1
NCCC1CSC1
CC(OC(C)(C)C)C(Nc1nc(NCCC(=O)NC2CCCC2)nc(NCCC2CSC2)n1)C(=O)N[Dy]
sEH
1
55,669,313
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
CCOC(=O)c1cnc(N)cn1
COC1CCC(CCN)CC1
CCOC(=O)c1cnc(Nc2nc(NCCC3CCC(OC)CC3)nc(NC(CC(=O)N[Dy])c3ccc(C)cc3)n2)cn1
sEH
1
249,273,342
O=C(O)C[C@@H](Cc1ccc(F)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cc1c(N)cccc1Br
Cc1c(Br)cccc1Nc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(F)cc2)n1
BRD4
1
70,606,092
N#Cc1cccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1nc2ccc(Cl)cc2o1
N#Cc1cccc(C[C@H](CC(=O)N[Dy])Nc2nc(Nc3nc4ccc(Cl)cc4o3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)c1
BRD4
1
83,420,972
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCc1c[nH]c2cc(Cl)ccc12
Nc1cc(Br)ccn1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCCc3c[nH]c4cc(Cl)ccc34)nc(Nc3cc(Br)ccn3)n2)CC1
sEH
1
13,339,479
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(N)cc1OC
Cc1cccc(OCCCN)c1C.Cl
COc1ccc(Nc2nc(NCCCOc3cccc(C)c3C)nc(NC(CCC(=O)OC(C)(C)C)C(=O)N[Dy])n2)cc1OC
BRD4
1
20,719,626
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CC(=O)SCCN.Cl
Cc1ccc(F)c(N)c1
CCCCC(Nc1nc(NCCSC(C)=O)nc(Nc2cc(C)ccc2F)n1)C(=O)N[Dy]
BRD4
1
72,033,035
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOc1cc2c(cc1CN)OC(C)C2.Cl
Cc1cc2cc(CN)ccc2[nH]1
CCOc1cc2c(cc1CNc1nc(NCc3ccc4[nH]c(C)cc4c3)nc(NC(CC3CCCCC3)C(=O)N[Dy])n1)OC(C)C2
sEH
1
98,873,427
O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
NCc1cccnc1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCc3cccnc3)nc(N[C@@H](Cc3ccc(F)cc3)C(=O)N[Dy])n2)ccc1=O
BRD4
1
218,273,783
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)nn1C
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ccnc(C(=O)N[Dy])c4)nc(Nc4cc(C)n(C)n4)n3)ccc2[nH]1
sEH
1
19,903,445
CCC(C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1cncc(N)c1
Cl.Cl.NCc1nccn1-c1ccccc1
CCC(C)C(Nc1nc(NCc2nccn2-c2ccccc2)nc(Nc2cncc(OC)c2)n1)C(=O)N[Dy]
sEH
1
125,550,453
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
COc1cc(Br)ccc1N
COc1cc(Br)ccc1Nc1nc(Nc2ccc(OC)c(OC)c2)nc(N[C@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[Dy])n1
BRD4
1
263,436,300
O=C(O)C[C@H](C/C=C/c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1ccc2c(c1)CCC2=O
O=C(C[C@H](C/C=C/c1ccccc1)Nc1nc(Nc2ccc3c(c2)CCC3=O)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)N[Dy]
BRD4
1
202,223,287
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc(-c2ccncc2)[nH]1
CC(C)c1nc(N)sc1Br
CC(C)c1nc(Nc2nc(NCc3nnc(-c4ccncc4)[nH]3)nc(Nc3ccc(F)cc3C(=O)N[Dy])n2)sc1Br
HSA
1
19,535,155
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cn[nH]c1
Nc1nc(Br)cn2ccnc12
CC(OC(C)(C)C)C(Nc1nc(Nc2cn[nH]c2)nc(Nc2nc(Br)cn3ccnc23)n1)C(=O)N[Dy]
HSA
1
153,659,827
O=C(Nc1c(I)cccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CC(C)NC(=O)NCCN.Cl.Cl
Cn1c(N)cc(=O)n(C)c1=O
CC(C)NC(=O)NCCNc1nc(Nc2c(I)cccc2C(=O)N[Dy])nc(Nc2cc(=O)n(C)c(=O)n2C)n1
HSA
1
82,261,739
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1(O)C2C3CC4C5C3CC2C5C41
CS(=O)C1(CN)CCC1
CS(=O)C1(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(O)C4C5CC6C7C5CC4C7C63)n2)CCC1
sEH
1
227,330,877
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
NC/C=C/Br
CC(CCN)S(C)=O
CC(CCNc1nc(NC/C=C/Br)nc(Nc2nc3ccc(C(=O)N[Dy])cc3s2)n1)S(C)=O
BRD4
1
174,823,855
O=C(Nc1cc(F)cc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
CCOC(=O)c1cc(N)[nH]n1
CCOC(=O)c1cc(Nc2nc(NCc3cncc(F)c3)nc(Nc3cc(F)cc(F)c3C(=O)N[Dy])n2)[nH]n1
HSA
1
252,098,572
O=C(O)C[C@@H](Cc1cccc(F)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1nc(CN)oc1C.Cl.Cl
Nc1cc(Cl)nc(Cl)c1[N+](=O)[O-]
Cc1nc(CNc2nc(Nc3cc(Cl)nc(Cl)c3[N+](=O)[O-])nc(N[C@@H](CC(=O)N[Dy])Cc3cccc(F)c3)n2)oc1C
HSA
1
97,797,140
O=C(N[C@@H](Cc1ccc(F)c(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1c2c(cc3c1CCC3)CCC2
CC(C)(CN)CCC#N
CC(C)(CCC#N)CNc1nc(Nc2c3c(cc4c2CCC4)CCC3)nc(N[C@@H](Cc2ccc(F)c(F)c2)C(=O)N[Dy])n1
sEH
1
81,930,566
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COCCNC(=O)CN.Cl
Cc1[nH][nH]c(=O)c1CCN
COCCNC(=O)CNc1nc(NCCc2c(C)[nH][nH]c2=O)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
254,358,162
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1nc(-c2ccncc2)no1
CC(=O)SCCN.Cl
CC(=O)SCCNc1nc(NCc2nc(-c3ccncc3)no2)nc(N[C@@H](CC(=O)N[Dy])Cc2cccs2)n1
BRD4
1
83,001,794
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(C)(CN)C1CC1
N#Cc1cnc2c(C#N)cnn2c1N
COC(C)(CNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2c(C#N)cnc3c(C#N)cnn23)n1)C1CC1
sEH
1
125,935,021
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1ccnc(C(N)=O)c1
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NCc3ccnc(C(N)=O)c3)nc(N[C@H](Cc3ccc([N+](=O)[O-])cc3)C(=O)N[Dy])n2)c1
HSA
1
57,530,166
Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
NCc1nccs1
Cc1ccc(C[C@H](Nc2nc(NCc3nccs3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)C(=O)N[Dy])cc1
BRD4
1
209,107,160
O=C(Nc1cccc(Br)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cn[nH]c1
Nc1ncnc2[nH]cnc12
O=C(N[Dy])c1c(Br)cccc1Nc1nc(Nc2cn[nH]c2)nc(Nc2ncnc3[nH]cnc23)n1
sEH
1
218,774,631
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Nc1ccc2cnccc2c1
O=C(N[Dy])c1cc(Nc2nc(Nc3ccc4cnccc4c3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)ccn1
BRD4
1
83,796,518
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1F
NCCCc1cc(=O)[nH][nH]1
O=c1cc(CCCNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cccnc3F)n2)[nH][nH]1
sEH
1
198,400,301
O=C(Nc1ccc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Cc1nnc(N)o1
CCOC(=O)c1ncccc1Nc1nc(Nc2nnc(C)o2)nc(Nc2ccc(Cl)cc2C(=O)N[Dy])n1
sEH
1
262,600,613
O=C(O)C[C@H](C/C=C/c1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)CCC#N
NCC1(C2CC2)CCCO1
CC(C)(CCC#N)CNc1nc(NCC2(C3CC3)CCCO2)nc(N[C@@H](C/C=C/c2ccccc2)CC(=O)N[Dy])n1
sEH
1
236,427,776
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
C=C1CCC(CN)CC1.Cl
Cl.NCC12CC3CC(CC(C3)C1)C2
C=C1CCC(CNc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(NC(CC(=O)N[Dy])c3ccc(Br)cc3)n2)CC1
sEH
1
83,054,972
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
Nc1ncccc1C=O
COc1ccc(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3ncccc3C=O)n2)c(C)c1OC
sEH
1
83,871,722
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1nccnc1Cl
Nc1ccc(Cl)cc1F
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(Nc3ccc(Cl)cc3F)nc(Nc3nccnc3Cl)n2)CC1
sEH
1